Hub : Genes

IQCE

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1340 0.0410 5.2e-04 0.022 0.020 0.026 0.024 0.017 9.6e-04 1.7e-03 3.7e-04 5.4e-04 3.0e-03
2 GTEx Breast Mammary Tissue 0.1790 0.0660 7.2e-03 0.038 NA 0.003 NA 0.004 4.6e-03 NA 2.1e-01 NA 1.8e-01
3 GTEx Breast Mammary Tissue (Male) 0.0517 0.1179 3.7e-01 0.048 NA -0.013 NA 0.097 3.0e-02 NA 1.0e+00 NA 3.0e-03
4 GTEx Breast Mammary Tissue (Female) 0.0743 0.0932 2.7e-01 -0.010 NA -0.006 NA -0.009 9.0e-01 NA 5.3e-01 NA 7.3e-01
5 GTEx Muscle Skeletal 0.0971 0.0342 2.6e-03 0.071 NA 0.047 NA 0.062 1.6e-07 NA 1.9e-05 NA 9.3e-07
6 GTEx Testis 0.4690 0.1060 1.3e-05 0.001 NA 0.140 NA 0.082 3.0e-01 NA 8.9e-07 NA 1.7e-04
7 METSIM Adipose 0.0714 0.0276 4.4e-03 0.012 0.018 0.018 0.026 0.025 5.6e-03 8.3e-04 7.3e-04 8.2e-05 9.2e-05
8 NTR Blood 0.0387 0.0130 9.9e-04 0.021 0.012 0.018 0.017 0.021 1.8e-07 4.7e-05 9.1e-07 2.5e-06 2.3e-07
9 ROSMAP Brain Pre-frontal Cortex 0.1761 0.0387 2.4e-07 0.096 0.066 0.117 0.116 0.127 2.2e-12 6.6e-09 9.3e-15 1.1e-14 4.6e-16

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 1.1 1.8 5.0 1.0 -0.6 2.2 0.0 -1.4 -2.2 -1.4 -1.1 -0.3
Bipolar Disorder or Schizophrenia 1.0 2.4 6.6 1.2 -0.7 1.9 0.0 -2.6 -1.8 -1.5 -1.9 -0.8
Depressed Affect (Nagel 2018) 0.6 1.2 2.2 -1.2 1.2 -1.1 0.0 1.3 -1.5 1.2 1.2 -0.4
Depression (Nagel 2018) 1.0 1.5 4.9 -1.5 2.2 -1.7 0.0 1.0 -1.2 0.5 0.2 0.5
Intelligence (Savage-Jansen 2018) 0.5 1.5 4.8 0.2 -2.0 2.2 0.0 1.0 -1.5 -1.0 0.1 0.2
Neuroticism (Nagel 2018) 0.6 1.5 3.7 -1.5 1.9 -1.6 0.0 0.9 -1.8 0.9 0.0 0.6
Schizophrenia (2018) 0.5 1.1 4.6 0.8 -0.4 0.7 0.0 -2.1 -0.4 -0.8 -1.5 -0.9
Schizophrenia vs Biploar Disorder 0.3 0.4 1.7 -0.8 0.6 -1.3 0.0 0.2 0.8 -0.2 0.1 -0.4
Worry (Nagel 2018) 0.7 1.5 7.1 -1.1 2.7 -1.3 0.0 0.0 -1.6 0.1 -0.4 0.8
Alzheimer’s Disease (in mother) 0.4 0.4 1.9 0.3 -1.4 1.1 0.0 -0.1 -0.8 -0.2 0.1 0.2
Alzheimer’s Disease (in father) 0.1 0.2 0.3 -0.2 0.5 -0.5 0.0 -0.3 -0.1 -0.4 0.6 -0.5
Alzheimer’s Disease (including proxy) 0.2 0.3 1.6 -0.3 0.7 -0.1 0.0 0.5 -0.4 0.2 1.3 0.2
Crohns Disease (2017) 0.3 0.6 2.0 -0.7 0.7 -0.5 0.0 -0.5 1.2 -0.0 -1.4 0.8
Irritable Bowel Disease (IBD) 0.4 0.9 3.3 -0.3 1.7 -1.0 0.0 -0.0 0.2 0.6 -0.5 1.8
Ulcerative Colitis (UC) 0.5 0.9 3.8 0.2 1.6 -0.7 0.0 0.7 0.1 0.9 0.6 1.9
Major Depression (MDD) 0.3 0.4 1.6 0.2 1.2 -0.0 0.0 -0.1 0.4 0.7 -0.4 1.1
Reaction Time 0.9 1.7 6.9 -1.2 -0.4 1.8 0.0 2.6 -1.1 -0.3 1.6 -0.1
Verbal and Numeric Reasoning (VNR) 0.1 0.3 1.1 -0.2 -0.4 0.1 0.0 -0.1 -1.0 -0.8 -0.7 0.4
Breast Cancer 0.7 1.7 4.8 1.6 1.6 -2.2 0.0 -1.4 -1.0 0.2 -0.9 0.9
Ovarian Cancer 0.9 1.1 3.0 -1.7 1.1 -0.3 0.0 1.0 1.5 -1.1 -1.0 0.5
Prostate Cancer 1.4 2.0 7.3 0.8 1.6 -0.9 0.0 -1.9 -2.7 -0.3 -1.5 0.5
Age at First Birth 0.4 0.6 2.6 -1.3 0.7 -0.4 0.0 1.6 0.3 -0.0 0.5 0.5
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 2.3 -0.8 0.1 0.3 0.0 -1.1 -0.2 -0.9 -1.5 -0.7
Coronary Artery Disease (CAD) 0.8 0.9 4.6 0.1 -1.5 0.6 0.0 -0.1 2.1 0.0 0.8 -0.7
Crohns Disease (2012) 0.2 0.3 1.0 -0.2 0.6 -0.6 0.0 -0.6 0.5 -0.4 -1.0 -0.4
Mean Putamen Volume 0.5 0.6 2.3 0.4 -0.6 1.5 0.0 -0.7 -0.9 0.7 -0.4 0.6
Fasting Glucose 2.2 2.6 8.8 0.1 0.1 0.1 0.0 3.0 -0.7 2.1 2.4 2.0
HbA1C 0.7 0.8 3.4 0.2 0.4 -0.1 0.0 -1.9 -1.2 0.6 -0.5 -1.2
HDL Cholesterol 0.6 1.0 3.5 1.2 -0.4 1.1 0.0 0.4 0.2 1.9 1.4 0.4
LDL Cholesterol 0.4 0.6 1.9 -1.4 1.2 -1.1 0.0 0.5 0.3 0.3 0.5 0.3
Lupus 0.7 1.0 5.9 2.4 -0.4 0.9 0.0 -1.2 -0.2 -0.5 -0.7 -0.3
Neuroticism (2016) 0.6 0.9 1.9 0.2 1.4 -1.3 0.0 1.2 0.0 1.2 1.3 0.1
Primary Biliary Cirrhosis 0.7 0.9 2.5 -1.3 1.1 -1.6 0.0 -0.8 -0.9 -0.5 -1.0 0.8
Rheumatoid Arthritis 0.6 0.8 3.9 1.3 0.8 -0.1 0.0 -0.0 -0.4 0.5 -0.5 2.0
Schizophrenia (2014) 0.6 1.4 4.0 0.5 -0.9 1.3 0.0 -2.0 -0.8 -1.0 -1.9 -0.5
Triglycerides 1.2 2.0 6.2 -1.1 -1.0 0.0 0.0 -1.5 -0.4 -2.5 -2.0 -1.7
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.1 -0.7 -1.1 1.3 0.0 0.7 -1.4 -0.1 -0.0 0.1
Ulcerative Colitis 0.8 1.2 5.5 0.4 1.6 -0.7 0.0 0.0 -1.1 0.9 0.0 2.3
Blood Eosinophil Count 0.8 6.1 22.3 -4.7 2.7 -4.2 0.0 0.7 1.2 1.6 1.4 -0.8
Blood Platelet Count 0.3 3.0 12.4 2.2 -1.2 -2.0 0.0 -1.7 3.5 -0.1 -1.3 -0.2
Blood Red Count 0.1 0.9 3.3 -1.3 0.3 -0.2 0.0 1.5 0.2 -1.8 0.6 0.2
Blood White Count 0.2 1.7 4.2 1.5 -0.9 -1.1 0.0 -2.1 -0.2 -1.9 -1.8 0.2
Heel T-Score 0.1 0.9 3.6 0.0 0.8 -1.9 0.0 -1.1 -1.0 -0.6 -0.6 -1.0
BMI 0.2 1.2 4.3 -0.0 -0.8 0.6 0.0 -0.7 -2.1 -1.9 -0.9 0.4
Height 0.3 5.5 28.5 -1.1 0.3 -0.2 0.0 0.2 -5.3 -3.6 -2.3 1.1
Waist Hip Ratio (WHR) 0.2 1.0 3.2 0.9 1.2 0.4 0.0 -0.2 -1.7 0.8 0.6 1.8
Systolic Blood Pressure 0.2 0.8 2.4 -0.4 1.0 -0.6 0.0 -1.1 1.6 0.8 0.3 -1.1
Smoking Status 0.9 2.2 5.7 2.3 -2.4 1.0 0.0 -2.0 -0.6 -0.8 -1.8 -0.2
Allergy or Eczema 0.9 2.5 5.9 -1.4 0.2 -1.2 0.0 -1.6 -2.0 -2.2 -2.4 -1.3
Cardiovascular Disease 0.4 1.2 4.9 -2.2 -0.1 0.3 0.0 0.3 2.1 -0.3 -0.1 -1.2
Hypothyroidism (self reported) 0.4 0.9 4.0 0.8 -0.6 0.1 0.0 -0.8 -0.0 -1.3 -0.7 -2.0
Respiratory disease 0.4 1.0 5.8 0.4 0.7 -2.4 0.0 -0.9 0.3 -0.6 0.1 -1.1
Type 2 Diabetes (T2D) (2018) 0.8 1.6 5.5 1.5 -0.6 0.7 0.0 -0.5 -2.3 -1.3 -1.2 1.6
Lung FEV1/FVC ratio 0.2 1.1 6.9 -0.2 -0.3 0.8 0.0 2.6 -0.2 -0.9 0.7 0.8
Lung FVC 0.2 1.1 4.5 -0.7 0.2 -0.2 0.0 1.1 1.5 2.1 1.3 -0.3
Neuroticism 0.6 1.4 4.8 -0.9 2.0 -2.2 0.0 1.1 -1.3 0.3 0.5 -0.3
Chronotype (morning person) 0.7 1.5 4.3 0.8 0.0 0.2 0.0 1.4 1.7 1.9 2.1 0.1
Hair Pigment 0.1 1.5 5.2 -1.8 1.3 1.1 0.0 2.3 -0.4 -0.1 1.5 -0.4
Tanning 0.3 4.2 18.9 2.8 -2.8 1.6 0.0 -0.7 4.4 0.2 -1.0 -0.0
Hand grip strength (left) 1.0 2.6 9.4 0.1 -1.3 1.1 0.0 -1.8 -3.1 -1.4 -2.4 0.5
Number of treatments/medications taken 1.1 2.0 8.9 -0.9 -0.5 -1.6 0.0 -1.5 -0.1 -1.6 -1.0 -3.0
Average weekly spirits intake 0.1 0.2 0.3 -0.2 0.0 -0.3 0.0 -0.4 0.5 0.5 -0.5 0.6
Sensitivity / hurt feelings 0.5 0.9 2.9 0.2 1.7 -1.4 0.0 0.2 -0.2 1.0 -0.0 1.6
Frequency of depressed mood in last 2 weeks 1.4 2.0 6.7 -0.8 2.6 -1.4 0.0 1.9 -0.7 1.1 1.3 1.4
Hearing difficulty/problems: Yes 1.3 2.0 7.9 -0.3 0.2 -0.6 0.0 -1.9 -1.5 -2.0 -2.8 -0.2
Relative age of first facial hair 0.2 0.3 1.3 -0.8 0.6 0.8 0.0 0.4 -0.1 0.1 -0.0 1.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 2.0 -0.5 0.7 -1.4 0.0 -0.8 1.1 -0.6 -0.1 0.0
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.7 0.1 -0.1 0.8 0.0 -0.4 0.2 0.4 0.1 -0.3
Ever had hysterectomy (womb removed) 0.4 0.4 3.0 0.5 -0.5 -0.3 0.0 -0.3 1.7 0.3 -0.0 -0.1
Systolic blood pressure, automated reading 0.1 0.2 0.8 0.2 -0.3 0.9 0.0 -0.3 0.3 -0.6 -0.3 -0.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.3 -0.8 -1.1 0.3 0.0 -0.8 -0.5 -1.1 -1.1 -0.4
Angina 0.5 0.7 1.8 -0.2 0.9 -1.3 0.0 -1.2 0.6 0.0 -0.9 -1.0
Medication for hormone replacement therapy 0.8 0.9 2.2 1.1 0.9 -1.5 0.0 0.1 1.0 0.5 1.4 0.6
Vitamin and mineral supplements 0.7 0.9 4.6 0.9 -0.2 1.0 0.0 -0.0 2.1 1.0 0.7 -0.4
Supplements: Zinc 1.0 1.1 4.3 -2.1 1.2 -1.0 0.0 1.6 -0.0 -0.2 0.4 -0.6
Medication: Co-codamol 1.7 2.0 5.5 0.5 -1.7 0.4 0.0 -2.3 0.5 -1.9 -2.3 -0.1
Medication: Metformin 1.6 2.3 7.0 -1.1 -0.2 0.8 0.0 0.3 -2.1 -2.6 -2.6 0.7
Diabetes (father) 0.8 1.0 4.1 0.5 -2.0 1.9 0.0 -0.8 0.2 -0.1 -0.5 0.2
Diabetes (mother) 0.6 0.7 2.2 -1.4 -0.6 -0.6 0.0 1.5 0.4 -1.3 0.0 0.0
Severe depression (siblings) 0.4 0.5 1.8 -0.0 -0.1 -0.1 0.0 -1.3 -0.0 -0.7 -1.3 -0.6
Pack years adult smoking proportion 0.7 1.0 2.2 -0.4 -0.5 1.5 0.0 1.5 1.3 0.8 1.2 0.5
Impedance of leg (right) 0.1 0.6 1.9 0.9 1.2 -0.8 0.0 -0.7 0.2 1.4 0.4 0.4
Leg fat-free mass (left) 0.6 3.3 13.6 -1.9 -0.9 0.3 0.0 0.2 -3.7 -2.9 -1.6 0.3
Trunk fat percentage 0.7 2.9 12.6 -1.3 1.6 -0.9 0.0 0.0 -3.5 -2.2 -1.4 1.3
Hand grip strength (right) 1.2 3.3 8.1 -0.4 -1.9 1.2 0.0 -1.7 -2.8 -2.6 -2.5 -0.8
Townsend deprivation index at recruitment 0.3 0.5 1.7 0.8 0.2 0.7 0.0 0.6 0.3 0.6 1.3 0.6
Current tobacco smoking 0.6 1.0 2.9 1.4 -1.7 0.7 0.0 -0.3 1.7 0.2 0.2 -0.7
Average weekly fortified wine intake 0.2 0.3 1.0 -0.9 1.0 -0.1 0.0 0.2 -0.4 -0.2 -0.4 0.3
Maternal smoking around birth 0.8 1.2 4.9 -0.4 -0.6 0.7 0.0 -0.7 -1.2 -1.0 -2.2 1.4
Fed-up feelings 0.6 1.0 2.9 0.9 0.2 0.5 0.0 1.2 -0.3 1.6 1.7 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 -0.5 1.3 -1.1 0.0 1.2 0.8 0.7 0.7 0.8
Relative age voice broke 1.5 2.3 6.1 -2.3 2.5 -0.9 0.0 2.0 1.4 0.7 0.4 1.2
Taking other prescription medications 0.6 0.9 2.6 -1.3 -0.0 -0.7 0.0 -0.9 0.3 -1.6 -1.0 -1.3
Age when periods started (menarche) 0.3 0.8 1.7 1.3 -0.2 1.3 0.0 -0.4 -0.6 1.2 0.6 1.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.7 0.2 1.2 -1.0 0.0 0.7 1.1 1.2 1.3 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 3.5 -0.8 1.2 -1.9 0.0 -0.1 -1.5 -0.6 -0.1 -0.7
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 3.4 0.0 0.8 -0.2 0.0 -0.1 0.0 1.9 0.7 0.1
Qualifications: CSEs or equivalent 1.0 1.4 3.5 1.1 1.9 -0.2 0.0 0.0 1.3 1.8 1.2 1.0
Serious illness, injury or assault to yourself 0.4 0.4 1.7 0.7 -0.9 -0.6 0.0 -0.4 0.7 -0.1 1.3 -0.3
High blood pressure 0.3 1.0 2.6 -1.2 -0.0 -0.4 0.0 -0.0 1.6 -1.2 -0.8 -1.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.5 0.3 0.6 -1.4 0.0 -1.5 -1.2 -0.8 -1.0 -1.6
Multivitamins +/- minerals 0.4 0.6 2.2 -0.2 0.6 -1.1 0.0 0.1 -1.5 0.4 0.1 1.1
Stomach or abdominal pain in last month 0.4 0.5 2.4 0.7 0.7 0.2 0.0 0.4 -1.0 0.1 -0.2 1.6
Supplements: Glucosamine 0.9 1.2 3.1 -1.3 -0.2 0.0 0.0 -0.8 -0.2 -1.8 -1.8 -1.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 0.6 -0.2 0.3 0.0 0.3 -0.1 0.7 0.5 0.6
Medication: Atenolol 0.9 1.2 5.5 -0.1 0.3 -1.7 0.0 -0.4 2.3 -0.8 -1.0 -0.2
Medication: Levothyroxine sodium 0.2 0.4 2.4 -0.2 0.4 0.5 0.0 0.2 0.1 -0.4 0.6 -1.6
Sitting height 0.2 1.5 7.6 0.4 -0.9 -0.7 0.0 -1.1 -2.8 -1.3 -1.2 0.1
Chronic bronchitis/emphysema (father) 0.7 0.8 3.2 -0.3 -0.8 0.2 0.0 -1.7 -0.6 -0.4 -1.8 0.2
High blood pressure (mother) 0.4 0.5 2.0 -1.3 1.4 -0.0 0.0 0.8 -0.1 -0.8 0.1 -0.1
Body mass index (BMI) 0.2 0.9 5.3 -0.3 -0.4 0.1 0.0 -0.3 -2.3 -1.4 -0.8 0.4
Impedance of leg (left) 0.2 0.8 2.2 1.3 1.4 -0.7 0.0 -0.8 -0.1 1.5 0.4 0.8
Leg predicted mass (left) 0.6 3.2 13.0 -1.9 -0.9 0.3 0.0 0.1 -3.6 -3.0 -1.6 0.2
Trunk fat mass 0.8 3.5 17.1 -1.4 0.8 -0.7 0.0 -0.1 -4.1 -2.8 -1.7 1.0
Waist circumference 0.4 1.5 8.9 -0.5 -0.1 0.4 0.0 0.1 -3.0 -1.6 -0.4 1.0
Number of incorrect matches in round 1.8 3.0 9.5 -0.2 -0.1 -0.3 0.0 -3.1 0.7 -2.5 -3.0 -1.2
Past tobacco smoking 0.4 0.8 1.9 -1.2 1.4 -0.8 0.0 0.6 0.8 1.1 1.0 -0.2
Alcohol usually taken with meals 0.3 0.5 2.2 0.0 -0.2 -0.5 0.0 0.2 0.8 -1.1 0.5 -1.5
Nervous feelings 1.3 2.4 10.1 -1.1 3.2 -1.9 0.0 0.2 -1.9 0.7 -0.4 1.7
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 8.7 -1.4 3.0 -1.8 0.0 1.7 -0.3 0.4 0.9 1.0
Hearing difficulty/problems with background noise 0.8 1.3 4.2 -0.0 0.3 -1.3 0.0 -1.0 -0.2 -1.7 -2.0 -1.2
Hair/balding pattern: Pattern 2 0.5 0.6 2.9 0.0 -1.7 0.6 0.0 -0.8 1.1 0.7 -0.3 -0.2
Had menopause 0.6 0.8 3.2 -0.5 -0.6 -0.6 0.0 -1.0 -0.4 -1.1 -1.8 -0.9
Had other major operations 1.0 1.3 4.4 -1.7 0.1 -0.6 0.0 -1.0 -1.4 -0.8 -2.1 0.1
Forced vital capacity (FVC) 0.1 0.6 1.9 0.1 -0.9 0.5 0.0 1.4 0.1 0.4 0.7 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 3.8 -1.5 0.4 -1.9 0.0 -0.9 -1.3 -1.7 -1.4 -1.5
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.7 -1.1 1.3 -1.1 0.0 0.0 -0.9 0.0 -0.5 0.8
Qualifications: None of the above 0.3 0.7 3.0 -0.0 -0.7 1.4 0.0 -0.2 1.7 0.9 -0.3 0.2
Financial difficulties in last 2 years 0.8 1.0 4.2 -0.3 0.4 -0.9 0.0 1.0 -1.6 -0.0 0.6 2.0
Mouth/teeth dental problems 1.0 1.5 7.7 0.3 -2.8 1.8 0.0 0.3 1.6 0.2 0.1 -0.0
Heart attack 0.8 1.0 3.7 -1.4 0.3 -0.6 0.0 0.5 1.9 -0.3 0.3 -1.5
Allergy 0.7 1.6 5.5 -0.8 -0.4 1.5 0.0 2.4 0.8 0.3 0.9 2.0
Pain all over the body in last month 0.3 0.3 0.7 0.8 -0.5 0.5 0.0 -0.7 -0.8 -0.2 -0.6 -0.1
Diabetes (self-reported) 0.9 1.4 5.6 0.1 0.9 -0.6 0.0 0.1 -2.4 -0.7 -1.4 2.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.0 1.7 -0.4 0.1 0.0 -1.4 -0.2 1.1 0.3 -0.8
Medication: Ramipril 0.6 0.8 2.0 -1.1 1.0 -0.8 0.0 1.4 -1.4 0.3 0.1 0.6
Medication: Simvastatin 0.2 0.2 1.0 0.2 -0.5 1.0 0.0 -0.6 -0.4 -0.3 -0.2 -0.5
Fluid intelligence score 0.2 0.5 1.3 -0.5 -0.8 0.5 0.0 1.1 -1.0 -0.5 0.6 0.3
Illnesses of siblings 0.4 0.5 1.4 0.6 -0.2 1.2 0.0 0.8 -0.4 0.9 1.0 0.3
Neuroticism score 0.6 1.3 4.3 -1.0 2.1 -1.6 0.0 1.2 -1.1 0.8 0.7 0.7
Weight 0.7 3.3 18.1 -0.9 -0.6 0.2 0.0 -0.3 -4.2 -2.7 -1.6 0.9
Impedance of arm (right) 0.5 2.1 8.2 -1.1 2.9 -1.5 0.0 0.7 -1.7 -0.2 -0.4 1.9
Arm fat percentage (right) 0.5 1.9 9.4 -1.2 1.4 -0.9 0.0 0.4 -3.1 -1.4 -0.5 1.1
Trunk fat-free mass 0.6 3.3 9.9 -0.9 -2.6 0.9 0.0 -0.3 -3.1 -3.0 -1.5 -0.7
Hip circumference 0.3 1.4 8.4 -0.5 -0.6 0.4 0.0 0.0 -2.9 -1.8 -0.7 0.4
Time employed in main current job 0.7 0.8 2.4 -0.5 0.6 0.2 0.0 0.1 -1.2 -0.8 -1.6 1.5
Alcohol intake versus 10 years previously 0.6 0.8 1.8 0.8 -0.9 1.4 0.0 -0.2 1.4 1.0 1.0 -0.4
Father’s age at death 0.4 0.5 1.4 -0.2 0.9 0.1 0.0 -0.8 0.4 -1.1 -1.2 0.7
Worrier / anxious feelings 0.6 1.1 3.6 -1.7 1.9 -0.7 0.0 0.1 -1.1 -0.9 -0.7 0.8
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 7.6 -0.3 2.8 -1.8 0.0 1.0 -1.3 0.5 0.7 0.9
Falls in the last year 1.5 2.1 5.5 -0.8 0.2 0.4 0.0 2.2 0.2 2.4 2.0 1.8
Hair/balding pattern: Pattern 3 0.3 0.4 1.7 -0.6 0.6 0.0 0.0 1.3 -0.3 -0.6 0.9 -0.5
Number of live births 0.9 1.3 4.1 0.8 -1.3 0.8 0.0 -2.0 -0.9 -0.9 -1.6 -0.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 5.1 0.1 -0.7 0.4 0.0 2.3 0.1 0.6 1.3 1.6
Pulse rate 0.3 0.5 2.3 -0.2 -0.7 -0.5 0.0 0.6 -1.1 -1.5 0.0 0.3
Happiness 1.1 1.3 7.8 0.6 0.7 -0.7 0.0 -2.8 -1.0 0.4 -1.0 -0.3
Noisy workplace 0.6 0.7 2.4 0.8 -1.5 0.8 0.0 -1.1 0.1 -0.2 -1.3 0.3
Qualifications: A levels/AS levels or equivalent 0.4 0.9 3.7 -0.3 0.0 1.2 0.0 0.8 -1.9 0.0 0.5 1.3
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.7 0.0 -0.8 -0.1 0.0 0.6 -0.8 -0.6 0.2 -0.5
Mouth/teeth dental problems: Dentures 0.2 0.4 1.7 -0.9 1.3 -0.1 0.0 -0.1 -0.3 0.5 -0.5 -0.4
Asthma 0.3 0.6 1.5 1.0 0.2 -1.2 0.0 -0.8 0.3 1.2 0.7 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.4 1.4 1.0 1.2 -0.9 0.0 -0.7 0.2 0.3 0.1 0.1
Medication: Cholesterol lowering 1.0 1.5 3.4 0.1 -1.2 -0.1 0.0 -1.4 1.6 -1.8 -1.0 -1.8
Depression (self-reported) 0.5 0.6 3.1 0.4 0.2 0.3 0.0 -1.3 -0.1 -0.5 -1.8 -0.2
Medication: Lansoprazole 0.7 0.8 4.6 0.3 -0.0 0.8 0.0 -1.1 -2.2 -0.1 -0.2 -0.9
Prospective memory result 0.6 0.7 2.8 0.1 1.4 -1.7 0.0 -0.8 0.1 0.1 -0.2 -1.0
Lung cancer (father) 1.3 1.6 5.0 2.2 0.9 -1.2 0.0 -1.3 -1.9 0.4 -0.4 1.2
Illnesses of mother 1.0 1.2 7.3 2.7 -0.5 -0.2 0.0 -0.4 0.4 1.3 0.4 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 3.0 -0.3 0.2 -0.1 0.0 1.7 -0.5 0.2 0.9 1.5
Pulse wave Arterial Stiffness index 1.2 1.4 4.2 1.1 -1.8 -0.2 0.0 -0.3 2.0 -1.8 -0.9 0.3
Impedance of arm (left) 0.4 1.9 9.4 -1.1 3.1 -1.8 0.0 0.3 -1.3 -0.1 -0.3 1.2
Arm fat mass (right) 0.6 2.5 13.8 -1.1 0.4 -0.3 0.0 -0.1 -3.7 -2.2 -1.3 1.0
Trunk predicted mass 0.6 3.3 10.3 -0.9 -2.6 0.8 0.0 -0.4 -3.2 -2.9 -1.5 -0.6
Standing height 0.5 4.6 22.4 -1.3 -0.8 0.1 0.0 -0.5 -4.7 -3.1 -2.4 1.1
Length of working week for main job 0.2 0.2 0.6 -0.5 -0.5 0.8 0.0 0.0 0.6 -0.5 -0.4 -0.1
Exposure to tobacco smoke at home 1.7 1.9 4.3 1.9 -0.0 0.3 0.0 0.1 2.0 2.1 1.9 1.3
Breastfed as a baby 1.5 1.9 5.9 1.8 0.3 0.7 0.0 0.7 2.4 1.8 1.9 -0.1
Tense / ‘highly strung’ 0.4 0.6 2.4 -1.5 1.1 0.5 0.0 0.4 -0.3 -0.8 -1.0 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 5.4 0.0 2.0 -0.1 0.0 -0.2 -2.0 1.2 -0.9 2.3
Hair/balding pattern: Pattern 4 0.4 0.8 2.2 1.0 -1.3 0.0 0.0 -1.0 0.8 -1.5 -1.0 -0.2
Birth weight of first child 0.2 0.4 1.8 0.4 -0.0 -0.1 0.0 -1.4 -0.4 -0.2 -1.2 -0.0
Peak expiratory flow (PEF) 0.2 0.6 1.8 0.7 -1.0 0.6 0.0 1.3 0.2 0.2 0.4 1.2
Pulse wave reflection index 0.5 0.7 4.0 0.5 -0.6 -0.2 0.0 0.5 2.0 0.9 0.4 0.5
Ever highly irritable/argumentative for 2 days 1.4 1.6 10.9 -0.0 -1.2 0.8 0.0 -0.4 -3.3 0.2 -0.5 1.0
Loud music exposure frequency 0.6 0.7 1.7 0.9 1.1 -1.3 0.0 0.5 -0.1 1.0 1.0 0.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.8 1.0 0.3 0.2 0.0 0.2 1.0 -0.1 1.3 -0.3
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 6.1 -1.0 2.5 -1.2 0.0 1.0 -1.8 -0.9 -0.5 1.9
Blood clot in the leg (DVT) 0.3 0.4 2.4 0.6 0.3 1.5 0.0 -0.8 -0.5 0.0 -0.1 0.3
Medication: Paracetamol 1.4 2.3 7.4 0.1 -0.4 -0.9 0.0 -2.6 -0.7 -2.2 -2.7 -0.4
Headache pain in last month 0.4 0.7 2.1 -0.7 1.5 -0.5 0.0 -0.4 -1.0 0.3 -0.5 1.3
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 7.7 -0.4 1.9 -0.4 0.0 1.1 -2.2 1.7 0.9 2.8
Glaucoma (self-reported) 1.7 2.0 4.7 -1.1 -2.0 2.0 0.0 2.2 0.7 -0.0 1.6 -1.3
Gout (self-reported) 0.5 0.7 2.2 -0.6 -1.4 -0.2 0.0 1.5 -0.1 -0.2 1.0 0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.7 0.3 -0.2 0.3 0.0 0.3 -0.4 -1.1 -0.4 -1.3
Medication: Amlodipine 0.4 0.6 2.9 -1.7 1.1 -1.0 0.0 0.2 -0.2 -0.2 -0.5 -0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.2 0.7 -1.1 0.1 0.0 -0.7 -1.1 0.8 0.5 -1.1
Birth weight 0.1 0.3 1.2 0.9 -0.1 0.3 0.0 -0.7 -1.1 -0.2 0.1 0.0
Chronic bronchitis/emphysema (mother) 1.1 1.3 4.1 -1.5 2.0 -0.9 0.0 1.5 0.1 1.3 0.9 0.2
High blood pressure (siblings) 0.2 0.3 1.6 0.4 0.7 -1.3 0.0 0.0 0.5 0.3 0.1 0.6
Forced vital capacity (FVC), Best measure 0.1 0.4 1.4 -0.5 0.1 -0.2 0.0 1.0 -0.9 0.1 0.3 1.2
Body fat percentage 0.5 2.1 10.3 -0.9 1.4 -0.9 0.0 -0.3 -3.2 -1.9 -1.1 0.8
Leg fat percentage (right) 0.2 0.6 4.3 -0.1 0.1 -0.1 0.0 -0.4 -2.1 -1.0 -0.3 0.2
Arm fat-free mass (right) 0.5 2.7 8.1 -0.9 -2.2 1.1 0.0 -0.6 -2.8 -2.5 -1.5 -0.7
Exposure to tobacco smoke outside home 0.8 1.1 2.9 0.2 1.3 -1.3 0.0 0.2 0.5 1.6 1.7 -0.6
Comparative body size at age 10 0.8 2.3 7.1 -1.4 -0.5 -0.7 0.0 -1.0 -1.8 -2.5 -2.7 -0.5
Number of full brothers 1.2 1.5 4.8 0.1 2.2 -0.7 0.0 1.2 1.7 1.0 0.8 1.5
Worry too long after embarrassment 0.6 1.1 2.9 -1.3 1.5 -1.3 0.0 0.6 -1.7 0.3 -0.5 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.3 2.9 10.2 -0.2 0.8 1.5 0.0 -0.4 -3.1 0.1 -1.9 3.2
Wheeze or whistling in the chest in last year 0.7 1.2 4.3 0.5 1.9 -2.1 0.0 0.1 0.6 0.5 1.3 -0.4
Number of children fathered 0.6 0.7 2.7 0.3 1.2 -1.4 0.0 -0.4 1.6 -0.2 0.2 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.4 0.1 -0.1 0.2 0.0 -1.5 -0.6 0.6 -1.5 0.5
Age at first live birth 0.4 0.8 3.3 -0.7 -0.3 0.5 0.0 -0.6 -1.8 -0.4 -1.4 0.7
Pulse wave peak to peak time 1.2 1.5 5.6 -1.1 1.7 0.3 0.0 0.2 -2.4 1.7 0.7 -0.1
Health satisfaction 1.2 1.6 4.8 -0.3 2.1 -2.2 0.0 -1.0 -1.6 -0.6 -0.9 0.6
Shortness of breath walking on level ground 0.4 0.5 1.7 -0.8 0.6 -0.3 0.0 -0.5 -1.3 -0.4 -0.5 0.8
Qualifications: College or University degree 0.9 2.8 15.5 0.0 -0.3 -1.1 0.0 -1.1 -3.9 -2.4 -1.0 -0.5
Eye problems/disorders: None of the above 0.7 0.8 2.8 1.4 -0.7 0.7 0.0 -1.0 1.7 -0.1 0.5 0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.6 -0.7 0.8 -0.5 0.0 1.6 0.6 0.2 1.0 0.1
Emphysema/chronic bronchitis 0.3 0.4 1.1 -0.7 0.6 -0.4 0.0 -0.1 1.1 -0.6 -0.8 0.5
Medication for pain relief, constipation, heartburn 1.1 1.9 5.7 -0.5 1.0 -0.2 0.0 2.4 0.1 2.0 2.3 1.1
Neck or shoulder pain in last month 0.6 0.9 5.2 0.2 1.0 0.5 0.0 -0.2 2.3 1.1 -0.4 0.5
Medication: Blood pressure 0.5 0.9 2.6 -1.2 -0.1 -0.5 0.0 0.3 1.4 -1.3 -0.2 -1.6
Angina (self-reported) 0.5 0.7 1.5 -0.4 0.8 -1.2 0.0 -1.2 0.5 -0.2 -0.8 -1.2
Migraine (self-reported) 0.9 1.1 4.6 0.1 -1.3 1.1 0.0 -0.4 1.1 -0.8 0.0 -2.1
Medication: Ibuprofen 0.7 0.8 3.3 0.7 1.8 -1.7 0.0 -0.1 -0.3 0.5 0.5 0.2
Medication: Allopurinol 0.6 0.8 2.8 0.2 -0.5 -0.6 0.0 1.5 -0.7 -0.4 0.8 1.7
Medication: Omeprazole 0.7 0.9 2.6 0.6 -1.2 1.6 0.0 -1.0 0.7 1.1 0.5 -0.7
Medication: Seretide 50 evohaler 0.8 1.0 2.2 -0.4 -0.2 -1.4 0.0 -1.5 0.1 -0.8 -1.2 -1.4
Mean time to correctly identify matches 0.6 1.2 3.5 -1.2 -0.4 1.8 0.0 1.9 -1.1 -0.5 0.9 -0.6
Heart disease (mother) 1.1 1.3 5.8 -1.9 -0.5 -0.9 0.0 0.3 -0.1 -0.7 0.9 -2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 6.1 -0.5 -1.8 1.4 0.0 0.7 -0.2 -2.5 -0.7 0.2
Whole body fat mass 0.7 2.9 16.0 -1.1 0.4 -0.3 0.0 -0.2 -4.0 -2.5 -1.3 0.5
Leg fat mass (right) 0.4 1.6 9.6 -0.8 -0.1 -0.1 0.0 -0.4 -3.1 -1.7 -1.0 0.4
Arm predicted mass (right) 0.6 3.1 9.3 -0.8 -2.4 1.1 0.0 -0.7 -3.0 -2.7 -1.6 -0.5
Pulse rate, automated reading 0.2 0.5 1.8 0.9 -1.4 0.6 0.0 -1.1 -0.3 -0.4 -0.5 -0.0
Alcohol intake frequency. 0.2 0.5 1.6 -1.1 1.0 0.3 0.0 0.3 1.3 0.1 0.3 -0.6
Comparative height size at age 10 0.3 1.9 5.9 1.0 -0.7 -0.6 0.0 -1.6 -2.4 -1.9 -1.8 0.4
Number of full sisters 0.2 0.2 0.6 0.3 -0.7 0.3 0.0 -0.4 -0.0 0.3 -0.8 -0.6
Suffer from ‘nerves’ 1.5 2.4 10.7 -1.4 3.3 -1.7 0.0 0.5 -1.4 1.2 0.1 1.7
Overall health rating 0.3 0.7 2.4 -0.7 0.9 -0.6 0.0 -0.4 -1.5 -1.0 -0.8 -0.0
Chest pain or discomfort 1.2 1.8 4.8 -0.1 2.2 -1.1 0.0 -1.8 -2.2 0.1 -1.1 1.0
Had major operations 1.0 1.2 5.2 -2.3 1.3 -1.1 0.0 0.7 0.3 -1.4 -0.5 0.2
Age at last live birth 1.2 1.8 6.6 -1.2 0.2 0.2 0.0 -0.1 -2.6 -0.6 -1.9 2.0
Family relationship satisfaction 0.3 0.3 1.2 -0.2 0.3 -0.5 0.0 -1.1 0.2 -0.4 -1.0 -0.3
Leg pain on walking 0.2 0.3 1.4 -0.1 -0.3 -0.1 0.0 -1.0 -1.2 -0.2 -0.2 -0.3
Qualifications: NVQ or HND or HNC or equivalent 2.1 2.5 9.2 0.3 1.4 0.2 0.0 1.6 0.8 3.0 1.7 2.2
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.2 0.7 1.4 -1.8 0.0 0.3 1.3 -0.5 -0.6 -0.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.6 0.0 1.0 0.6 0.0 -0.8 1.1 1.6 -0.5 -0.1
Medication: Aspirin 0.8 1.1 2.9 -1.7 -0.3 0.9 0.0 -0.7 -0.1 -1.4 -1.7 -0.9
Supplements: Vitamin C 0.2 0.2 0.7 0.1 -0.4 -0.6 0.0 0.3 -0.6 -0.8 0.2 -0.7
Knee pain experienced in last month 0.6 0.9 2.0 -0.5 -0.8 -0.3 0.0 -1.3 -1.4 -1.2 -1.4 -0.4
Hypertension (Self-reported) 0.3 1.0 2.9 -0.9 -0.5 -0.3 0.0 -0.4 1.6 -1.1 -0.8 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.0 -0.2 0.3 -0.2 0.0 -1.0 -0.1 -1.0 -0.4 -0.4
Illnesses of father: Heart disease 1.3 1.7 4.1 -0.8 -2.0 -0.1 0.0 -1.3 -0.5 -1.4 -1.9 -1.9
Illnesses of siblings: Diabetes 0.3 0.4 1.1 -0.6 0.6 -1.1 0.0 0.5 0.4 -0.4 -0.5 0.9
Smoking status: Previous 0.4 0.6 1.9 1.0 -0.7 0.7 0.0 -0.2 -1.4 -0.6 -0.7 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 3.1 -1.1 -0.1 0.7 0.0 1.2 -1.5 -1.0 -0.3 1.8
Whole body fat-free mass 0.6 3.4 12.3 -1.4 -2.0 0.8 0.0 -0.0 -3.5 -3.0 -1.5 -0.3
Leg fat-free mass (right) 0.6 3.2 13.3 -1.8 -1.1 0.5 0.0 0.2 -3.6 -2.9 -1.5 0.3
Arm fat percentage (left) 0.4 1.7 7.7 -1.1 1.3 -0.9 0.0 0.1 -2.8 -1.6 -0.6 0.8
Average weekly red wine intake 0.2 0.3 1.0 0.3 -1.0 -0.1 0.0 -0.3 -0.9 -0.8 0.2 -0.3
Handedness (chirality/laterality): Left-handed 1.0 1.2 6.2 0.5 2.5 -1.7 0.0 -0.2 -0.8 0.7 0.2 0.3
Mood swings 0.6 1.1 3.8 -1.2 1.0 0.1 0.0 1.9 -1.1 0.8 0.9 0.8
Loneliness, isolation 0.5 0.7 2.0 -1.0 0.4 -1.0 0.0 0.7 -1.4 0.9 0.6 -0.3
Long-standing illness, disability or infirmity 0.3 0.5 1.5 -1.2 0.5 -0.7 0.0 -0.5 -0.7 -0.8 -0.5 -0.5
Ever had bowel cancer screening 2.3 2.7 11.4 -0.2 -1.8 0.9 0.0 -1.6 -0.5 -2.4 -3.4 0.2
Diabetes diagnosed by doctor 0.8 1.3 6.0 0.3 0.6 -0.1 0.0 -0.1 -2.5 -1.0 -1.4 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 3.4 1.8 -0.8 -0.6 0.0 -1.4 -0.3 -0.4 -0.1 -0.4
Friendships satisfaction 0.7 0.9 2.8 -1.7 1.2 0.7 0.0 0.1 -1.5 0.8 0.3 0.2
Qualifications: nursing, teaching 0.8 1.3 4.2 -0.4 2.0 -2.0 0.0 1.2 -1.2 -0.3 0.7 0.4
Commuting to job workplace: Walk 0.5 0.5 2.8 -0.6 -0.1 -0.6 0.0 -1.7 -0.4 -0.4 -0.7 0.3
Eye problems/disorders: Cataract 1.0 1.2 4.3 -0.7 0.4 -1.8 0.0 -0.6 -1.0 -1.1 -2.1 0.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 5.1 2.2 -0.2 0.1 0.0 -2.1 -1.2 -0.4 -0.5 -0.5
Medication for cholesterol 0.4 0.6 3.4 1.9 -0.7 0.4 0.0 -0.1 0.2 0.9 0.7 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 7.5 0.2 1.1 0.5 0.0 0.9 -2.7 0.3 1.1 0.7
Back pain experienced in last month 0.4 0.6 2.0 0.8 -0.6 -0.1 0.0 0.6 1.4 -0.4 0.9 -0.9
Mineral and other dietary supplements 0.8 1.0 4.2 2.1 -0.7 1.3 0.0 0.2 0.6 0.5 0.9 1.3
Breast cancer (self-reported) 1.1 1.3 3.5 0.3 -1.7 0.8 0.0 -1.2 0.9 -1.0 -1.0 -1.9
Asthma (self-reported) 0.3 0.6 1.7 1.0 0.1 -1.3 0.0 -0.7 0.2 0.9 0.8 -0.6
Osteoporosis (self-reported) 0.8 0.9 3.3 1.1 -0.9 0.6 0.0 -1.4 0.4 -0.4 -0.8 -1.8
Osteoarthritis (self-reported) 0.7 0.9 2.2 -1.1 -1.0 1.2 0.0 -0.7 0.5 -0.9 -1.0 -1.5
Medication: Aspirin 0.7 0.9 3.1 -1.5 -0.0 0.5 0.0 -0.8 -0.4 -1.3 -1.8 -0.5
Medication: Gliclazide 0.7 0.8 3.3 -0.2 0.7 -0.1 0.0 0.0 -0.1 -1.8 -1.6 0.8
Illnesses of father: None of the above (group 1) 1.0 1.2 5.4 0.6 0.9 0.3 0.0 0.8 -1.3 1.3 0.6 2.3
Smoking status: Current 0.8 1.2 4.0 1.6 -2.0 0.7 0.0 -0.8 1.5 -0.0 -0.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 2.3 -1.5 0.4 -0.2 0.0 0.9 -0.2 -0.2 0.2 -0.4
Whole body water mass 0.6 3.4 11.6 -1.2 -2.1 0.9 0.0 -0.1 -3.4 -3.1 -1.6 -0.3
Leg predicted mass (right) 0.6 3.2 13.6 -1.8 -1.1 0.5 0.0 0.2 -3.7 -2.9 -1.5 0.3
Arm fat mass (left) 0.5 2.3 12.6 -0.9 0.5 -0.4 0.0 -0.3 -3.6 -1.9 -1.3 1.0
Number of self-reported non-cancer illnesses 1.3 2.3 9.8 -1.2 -0.5 -0.3 0.0 -1.7 0.9 -1.7 -1.7 -3.1
Average weekly champagne plus white wine intake 0.2 0.3 1.2 -0.1 1.1 -0.7 0.0 -0.0 -0.2 -0.4 -0.7 0.6
Miserableness 1.3 2.3 7.6 0.7 1.4 -0.1 0.0 2.1 -0.2 2.8 2.0 1.6
Guilty feelings 0.2 0.3 1.1 -0.6 0.1 -0.7 0.0 0.3 0.1 -0.9 -0.6 -1.0
Wears glasses or contact lenses 0.3 0.4 1.8 0.6 0.7 -1.3 0.0 -0.4 0.2 -0.3 -0.6 -0.5
Ever taken oral contraceptive pill 1.7 1.9 7.4 -1.2 0.7 1.5 0.0 1.1 -2.7 1.3 0.8 1.3
Hearing aid user 1.6 1.8 12.8 0.5 -0.8 1.3 0.0 -0.7 -3.6 -0.0 -0.7 0.2
Mother’s age at death 0.9 1.1 7.3 0.3 -0.6 -0.2 0.0 -0.6 -2.7 -1.2 -0.8 -0.4
Financial situation satisfaction 0.9 1.1 3.0 0.1 1.7 -1.6 0.0 -0.9 0.0 1.6 0.8 0.6
Tinnitus: Yes, now most or all of the time 0.2 0.3 1.0 -0.5 0.1 0.6 0.0 0.8 -0.3 0.2 -0.1 1.0
Commuting to job workplace: Public transport 0.9 1.1 3.6 0.2 1.5 -1.9 0.0 0.7 -1.0 -0.2 0.4 1.6
Eye problems/disorders: Glaucoma 1.6 2.0 7.5 -1.4 -1.2 1.5 0.0 2.7 0.3 0.3 1.7 -1.2
Medication: Blood pressure 0.7 1.3 3.8 -2.0 1.0 -0.6 0.0 -1.3 0.0 -1.0 -1.8 -0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.7 2.8 0.3 -0.6 -0.7 0.0 -0.7 0.3 -1.7 -1.0 -0.8
Supplements: Fish oil (including cod liver oil) 1.0 1.3 5.5 -1.5 1.5 -2.4 0.0 0.4 -0.9 0.6 0.2 -0.5
High cholesterol (Self-reported) 0.6 1.1 3.6 -0.2 -1.0 -0.1 0.0 -0.8 0.9 -1.9 -1.0 -1.7
Medication: Bendroflumethiazide 0.6 0.8 1.5 -0.8 0.4 -1.2 0.0 -1.2 0.4 -1.2 -0.8 -1.2
Medication: Paracetamol 0.9 1.3 3.6 -0.6 -0.8 -0.5 0.0 -1.3 -1.4 -1.9 -1.6 -1.0
Medication: Lisinopril 1.5 1.9 10.0 -1.1 1.8 -3.2 0.0 0.3 -1.1 -0.5 0.4 -1.2
Medication: Atorvastatin 0.3 0.4 1.4 -0.0 -0.5 -0.4 0.0 -0.6 0.9 -1.2 -0.9 0.0
Illnesses of father: High blood pressure 0.6 0.8 4.5 0.1 -0.4 -0.0 0.0 -0.0 2.1 -0.3 0.5 -1.3
Alcohol drinker status: Never 0.9 1.1 4.8 -2.2 -0.1 0.9 0.0 -0.2 -1.1 -1.4 -1.0 -0.5
Ever smoked 0.4 0.6 2.4 1.1 -1.6 0.6 0.0 -0.0 -0.3 -1.0 -0.6 0.5
Basal metabolic rate 0.6 3.5 15.1 -1.4 -1.7 0.6 0.0 -0.1 -3.9 -3.0 -1.6 -0.0
Leg fat percentage (left) 0.2 0.7 4.5 0.0 0.3 -0.2 0.0 -0.6 -2.1 -1.1 -0.5 0.3
Arm fat-free mass (left) 0.6 2.9 11.2 -0.5 -2.3 1.2 0.0 -0.3 -3.3 -2.3 -1.4 -0.0
Number of operations (self-reported) 0.8 1.3 4.3 -2.1 0.3 0.1 0.0 -0.8 0.1 -1.6 -1.9 0.1
Average weekly beer plus cider intake 1.0 1.4 3.8 0.5 1.8 -1.1 0.0 -0.4 -2.0 0.6 -0.1 1.9
Irritability 0.9 1.5 3.7 -1.4 1.5 -1.8 0.0 0.7 -1.0 0.6 -0.7 1.9
Risk taking 0.2 0.3 0.9 0.1 1.0 -0.7 0.0 -0.0 -0.6 -0.3 -0.5 0.3
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.8 0.0 -0.3 -0.7 0.0 -0.9 0.9 -1.6 -1.7 -1.5
Fractured/broken bones in last 5 years 0.2 0.3 0.8 0.1 -0.2 0.4 0.0 0.3 -0.4 0.9 0.8 -0.8
Age started oral contraceptive pill 0.7 0.8 3.9 -2.0 -0.6 0.1 0.0 0.3 -0.4 0.2 -0.5 -1.6
Diastolic blood pressure, automated reading 0.2 0.6 2.9 -0.5 0.3 1.2 0.0 0.1 -1.7 -0.6 -0.5 0.2
Ever depressed for a whole week 0.4 0.5 1.7 -0.1 1.3 -0.9 0.0 -0.7 -0.7 0.9 0.2 -0.1
Unable to work because of sickness or disability 0.8 1.0 3.6 1.9 -0.7 1.1 0.0 -1.1 0.3 1.2 -0.2 1.1
Commuting to job workplace: Cycle 1.5 1.9 5.8 1.8 0.5 0.6 0.0 -0.7 -2.4 1.9 1.1 1.4
Myopia 0.2 0.3 1.1 0.4 -0.3 -0.2 0.0 1.0 -0.1 -0.2 1.1 0.2
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.7 1.3 0.0 0.2 0.0 0.7 -1.5 1.1 1.0 1.9
Cholesterol lowering medication 0.8 1.2 3.2 -1.7 0.2 1.2 0.0 0.1 -1.8 -1.1 -1.1 0.8
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.0 0.4 -0.6 1.3 0.0 -0.7 1.1 1.4 1.0 -0.5
Pain experienced in last month 0.2 0.3 1.0 0.3 0.4 -0.3 0.0 0.2 -0.9 0.8 1.0 -0.3
Supplements: Calcium 3.2 3.5 9.2 -0.5 -1.8 0.8 0.0 -1.8 -0.6 -3.0 -3.0 -2.4
Basal cell carcinoma (self-reported) 0.4 0.5 2.5 -0.2 -0.6 1.6 0.0 0.3 0.3 -0.4 -0.8 0.6
Heart attack/myocardial infarction (self-reported) 0.8 1.1 3.8 -1.4 0.1 -0.7 0.0 0.6 1.9 -0.3 0.4 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 3.6 0.8 0.0 1.9 0.0 -0.7 -0.7 0.1 -0.0 0.3
Heart disease (siblings) 0.5 0.6 1.5 -1.2 0.9 -0.1 0.0 0.8 0.3 0.6 1.2 -0.5
Alcohol drinker status: Previous 1.0 1.1 3.4 -0.5 1.8 -1.2 0.0 1.4 -0.1 -0.2 -0.1 1.8
Pack years of smoking 0.5 0.7 1.9 -0.6 -0.4 1.4 0.0 1.0 1.4 0.6 0.7 0.2
Impedance of whole body 0.3 1.5 8.1 -0.2 2.8 -1.6 0.0 -0.1 -0.7 0.9 0.1 1.3
Leg fat mass (left) 0.4 1.7 10.0 -0.6 -0.1 -0.1 0.0 -0.6 -3.2 -1.8 -1.1 0.5
Arm predicted mass (left) 0.5 2.4 8.5 -0.7 -2.2 0.9 0.0 -0.3 -2.9 -2.2 -1.2 -0.3