TWAS hub - ARHGAP12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1270	0.0320	7.8e-13	0.116	0.120	0.145	0.139	0.138	6.4e-14	2.1e-14	2.8e-17	1.6e-16	1.8e-16
2	GTEx	Artery Aorta	0.1450	0.0620	3.6e-03	0.034	NA	0.014	NA	0.048	5.8e-03	NA	5.2e-02	NA	1.2e-03
3	GTEx	Prostate	0.1490	0.0640	4.0e-03	0.086	NA	0.108	NA	-0.009	3.5e-03	NA	1.2e-03	NA	6.2e-01
4	METSIM	Adipose	0.0410	0.0210	2.4e-03	0.028	0.012	0.013	0.015	0.022	3.6e-05	5.4e-03	3.7e-03	2.2e-03	2.6e-04
5	YFS	Blood	0.0301	0.0102	7.2e-09	0.030	0.025	0.030	0.026	0.023	3.6e-10	7.8e-09	4.3e-10	3.6e-09	4.2e-08
6	TCGA	Prostate Adenocarcinoma	0.0937	0.0399	1.3e-11	0.135	0.110	0.105	NA	0.122	5.4e-14	1.6e-11	4.3e-11	NA	1.0e-12
7	TCGA	Thyroid Carcinoma	0.0520	0.0320	7.7e-04	0.026	0.015	0.025	NA	0.018	1.4e-03	1.1e-02	1.5e-03	NA	6.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Pain type(s) experienced in last month: Hip pain	6.4	8.0	13.6	1.0	-0.9	3.7	3.6	3.0	3.4	2.7
Prostate Cancer	4.9	6.9	11.8	2.1	0.5	3.0	3.4	2.9	3.1	2.2
Ever taken oral contraceptive pill	4.7	5.2	9.1	-2.4	0.5	-3.0	-2.2	-2.6	-2.4	-2.0
Schizophrenia (2014)	4.6	10.3	16.0	1.4	-3.2	3.2	2.4	3.7	3.7	4.0
Irritability	4.2	7.1	16.2	-4.0	2.5	-2.5	-0.6	-1.6	-3.3	-2.8
Schizophrenia (2018)	3.7	7.7	11.2	1.4	-2.6	3.0	2.2	3.1	3.4	3.3
Breast Cancer	3.7	8.9	14.5	-3.7	1.5	-3.8	-0.7	-3.5	-3.2	-3.1
Forced expiratory volume in 1-second (FEV1)	3.6	12.1	21.4	-1.3	-1.3	-4.0	-4.6	-4.1	-3.9	-3.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.4	12.4	-1.6	-0.4	-3.5	-3.5	-3.3	-3.0	-2.1
Body Mass Index (BMI) (2010)	3.3	4.5	8.7	1.5	2.1	2.4	3.0	2.1	2.2	1.3
Lung FEV1/FVC ratio	3.3	16.6	25.0	-4.3	1.4	-5.0	-3.5	-4.3	-4.8	-4.2
Prospective memory result	3.2	3.9	9.6	-2.5	3.1	-2.4	0.2	-0.7	-2.0	-1.3
Vitamin and mineral supplements	3.1	4.2	14.2	-0.3	1.9	2.0	3.8	2.2	1.4	1.0
Lung FVC	3.0	15.1	25.7	-2.1	0.3	-5.1	-4.7	-3.4	-4.8	-4.4
Medication: Co-codamol	2.9	3.3	6.1	-1.4	1.1	-1.4	-1.3	-2.3	-2.3	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.1	20.2	-0.8	-1.7	-3.5	-4.5	-3.5	-3.1	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	5.6	1.6	-1.5	1.6	0.3	2.3	1.9	2.4
Leg fat percentage (left)	2.7	9.9	17.4	2.3	-1.8	3.8	2.1	3.3	4.2	3.6
Trunk fat mass	2.6	11.0	22.0	3.1	-3.4	3.4	0.2	2.8	3.9	4.7
Leg fat mass (left)	2.6	10.1	16.5	2.5	-2.5	3.8	1.5	3.1	4.1	3.9
Trunk fat percentage	2.5	10.1	20.7	3.1	-2.9	3.2	0.2	2.9	3.6	4.6
Whole body fat mass	2.5	10.3	19.4	2.8	-3.0	3.6	0.7	2.8	3.9	4.4
Systolic Blood Pressure	2.4	12.0	29.6	-4.0	5.4	-2.1	3.0	-0.3	-2.2	-4.5
Body fat percentage	2.4	9.3	18.6	2.6	-2.5	3.3	0.7	2.9	3.7	4.3
Age at first live birth	2.4	4.3	13.8	2.4	-2.1	-1.1	-3.7	-2.1	-0.6	0.2
Health satisfaction	2.4	3.1	7.1	1.1	-1.2	2.7	1.2	1.5	2.4	1.5
Overall health rating	2.4	5.3	11.8	1.6	-0.6	3.4	2.0	2.9	2.6	1.8
Bipolar Disorder or Schizophrenia	2.3	5.5	9.2	0.7	-2.3	2.3	2.1	3.0	2.7	2.6
Leg fat mass (right)	2.3	8.8	14.7	2.3	-2.5	3.5	1.4	2.8	3.8	3.7
Ulcerative Colitis	2.2	3.3	6.8	0.2	-0.6	2.0	2.0	2.6	2.5	1.0
Depression (self-reported)	2.2	2.7	6.3	-2.2	2.5	-1.6	0.6	-0.3	-1.7	-1.3
Medication: Atorvastatin	2.2	2.7	7.2	0.2	-2.4	2.7	0.3	1.2	1.3	1.6
Pain experienced in last month	2.2	3.7	8.5	-0.6	-0.5	-2.2	-2.9	-2.7	-2.1	-0.8
Ulcerative Colitis (UC)	2.1	3.9	8.1	0.5	0.6	2.2	2.8	2.5	2.5	1.0
Hearing difficulty/problems: Yes	2.1	3.3	5.6	-2.4	0.4	-2.3	-1.1	-2.2	-2.2	-0.9
Severe depression (siblings)	2.1	2.3	4.2	-0.0	0.4	1.5	2.1	1.6	1.7	2.0
Peak expiratory flow (PEF)	2.1	4.9	12.8	0.2	-1.5	-2.2	-3.6	-2.6	-2.1	-1.7
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	7.3	0.7	0.0	-2.4	-2.7	-2.2	-2.0	-1.3
Arm fat mass (left)	2.1	8.7	15.5	2.4	-2.2	3.5	1.2	2.8	3.7	3.9
Schizophrenia vs Biploar Disorder	2.0	2.7	5.1	1.5	-1.4	2.1	-0.0	0.8	2.0	2.3
Alzheimer’s Disease (in mother)	2.0	2.4	5.1	-1.3	0.6	-2.3	-0.8	-1.5	-2.0	-1.6
Multivitamins +/- minerals	2.0	2.5	6.0	-0.1	-1.1	-2.1	-2.4	-1.6	-1.4	-1.4
Arm fat mass (right)	2.0	8.4	15.1	2.2	-2.1	3.5	1.3	2.8	3.6	3.9
Exposure to tobacco smoke outside home	2.0	2.6	6.6	0.7	1.3	1.5	2.6	2.0	1.5	0.9
Supplements: Vitamin C	2.0	2.4	8.3	0.0	-1.0	-1.3	-2.9	-2.0	-1.3	-0.5
Irritable Bowel Disease (IBD)	1.9	4.5	15.0	-0.6	0.7	1.8	3.9	2.6	2.3	0.7
Medication: Ventolin 100micrograms inhaler	1.9	2.5	7.5	-1.2	2.1	-0.1	2.7	2.0	-0.0	-0.5
Leg fat percentage (right)	1.9	7.0	12.8	1.7	-1.7	3.3	1.9	2.7	3.6	3.0
Medication: Blood pressure	1.9	3.4	10.0	-1.4	0.7	2.0	3.2	2.0	1.6	0.8
Suffer from ‘nerves’	1.9	2.9	5.9	-2.4	2.4	-1.0	1.1	0.0	-1.6	-2.1
Arm fat percentage (left)	1.9	7.7	14.7	2.0	-1.6	3.2	1.4	2.9	3.4	3.8
Wears glasses or contact lenses	1.9	2.2	6.0	-1.3	-0.5	-1.8	-2.5	-0.7	-1.8	-0.5
Intelligence (Savage-Jansen 2018)	1.8	5.4	17.6	-0.4	-1.0	-2.4	-4.2	-1.7	-2.4	-2.1
Angina	1.8	2.3	5.0	-2.2	0.8	-0.9	-0.5	-1.8	-1.4	-2.1
Body mass index (BMI)	1.8	7.5	13.2	1.5	-1.0	3.6	2.3	3.2	3.3	3.1
Waist circumference	1.8	6.5	11.6	1.5	-1.3	3.4	2.2	2.9	3.0	2.8
Forced vital capacity (FVC)	1.8	7.0	15.8	-0.2	-1.8	-3.0	-4.0	-2.9	-2.7	-2.1
Weight	1.8	8.8	14.5	2.8	-3.4	3.3	0.3	2.3	3.4	3.8
Number of children fathered	1.8	2.0	4.9	-0.7	-1.0	1.7	1.1	1.2	1.4	2.2
Miserableness	1.8	3.2	7.1	-0.9	-1.0	1.9	2.7	1.8	1.8	1.7
Mother’s age at death	1.8	2.3	4.7	2.2	-0.9	0.7	-0.5	1.8	1.4	2.1
Bipolar Disorder (2011)	1.7	1.6	3.0	1.2	0.5	1.6	1.2	1.7	1.3	0.9
BMI	1.7	10.0	19.1	1.2	-0.7	4.4	3.2	3.7	3.9	3.2
Waist Hip Ratio (WHR)	1.7	7.4	20.5	0.8	1.6	3.0	4.5	3.0	2.8	1.7
Qualifications: College or University degree	1.7	5.4	15.6	1.5	-3.0	-2.3	-4.0	-2.0	-0.6	1.4
Heart disease (mother)	1.7	2.1	4.5	2.0	0.2	2.1	1.3	1.4	1.5	0.2
Long-standing illness, disability or infirmity	1.7	2.5	4.3	1.2	-1.2	2.0	1.1	2.1	2.0	1.2
Pain all over the body in last month	1.6	1.7	4.0	-0.2	0.9	1.0	2.0	1.9	1.2	1.0
Arm fat percentage (right)	1.6	6.4	12.1	1.6	-1.4	3.0	1.4	2.7	3.1	3.5
Blood clot in the leg (DVT)	1.6	2.1	7.3	-0.7	2.7	-0.6	1.9	0.9	-0.4	-1.5
Pulse rate, automated reading	1.6	5.3	9.8	2.9	-0.4	3.1	1.3	2.1	2.9	2.0
Age at last live birth	1.6	2.3	7.7	2.3	-1.1	-0.7	-2.8	-0.9	0.1	0.9
Age started oral contraceptive pill	1.6	2.0	5.3	-1.6	0.2	-1.5	-1.3	-2.3	-1.2	-0.9
Type 2 Diabetes (T2D) (2018)	1.5	2.8	7.3	0.2	1.1	1.7	2.7	2.1	1.4	1.3
Systolic blood pressure, automated reading	1.5	4.2	11.7	-2.0	3.4	-0.3	3.1	1.1	-0.4	-1.8
Qualifications: CSEs or equivalent	1.5	2.0	7.0	1.3	-2.6	0.9	-0.1	1.0	1.0	1.5
High blood pressure (mother)	1.5	2.0	4.4	0.3	1.0	2.0	2.1	1.7	1.4	0.5
Qualifications: None of the above	1.5	3.3	11.6	-1.6	3.4	0.1	2.1	0.1	-1.1	-1.9
Alcohol intake versus 10 years previously	1.5	2.3	4.5	0.8	-0.0	2.1	2.1	1.9	1.6	0.8
Illnesses of mother	1.5	1.9	3.1	-1.8	0.1	-1.7	-0.4	-1.8	-1.5	-1.4
Forced vital capacity (FVC), Best measure	1.5	5.5	15.7	0.5	-2.5	-2.5	-4.0	-2.3	-1.9	-1.0
Angina (self-reported)	1.5	1.9	4.2	-2.1	0.8	-0.9	-0.5	-1.5	-1.3	-1.9
Commuting to job workplace: Cycle	1.5	1.9	3.3	0.0	0.6	-1.1	-1.6	-1.8	-1.8	-1.5
Basal cell carcinoma (self-reported)	1.5	1.8	5.8	1.1	-1.2	0.7	0.2	0.9	1.7	2.4
Depressed Affect (Nagel 2018)	1.4	2.9	6.5	-1.1	0.1	2.1	2.5	1.6	1.6	1.7
Supplements: Zinc	1.4	1.5	6.0	0.5	-1.7	-0.2	-2.5	-1.0	-0.7	-0.1
Maternal smoking around birth	1.4	2.0	6.7	-1.2	1.0	1.7	2.6	1.4	0.3	-0.2
Fed-up feelings	1.4	2.6	8.4	0.4	-1.0	2.9	1.3	1.4	1.6	1.5
Medication: Levothyroxine sodium	1.4	2.4	6.0	-0.5	0.3	-2.4	-2.2	-0.6	-2.0	-1.3
Pulse rate	1.4	2.3	5.3	1.2	0.0	2.3	1.2	1.6	1.5	1.8
Chest pain or discomfort	1.4	2.1	4.0	-1.7	2.0	-1.1	0.3	-0.6	-1.4	-2.0
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.3	-1.3	1.1	-1.3	-0.1	-1.3	-1.5	-1.8
Eye problems/disorders: Cataract	1.4	1.6	2.9	-1.2	-0.3	-1.7	-1.1	-1.1	-1.6	-1.2
Medication: Lisinopril	1.4	1.8	3.6	-1.6	1.9	-0.0	1.3	-0.6	-1.2	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.4	1.9	6.5	-0.6	2.5	-0.6	1.8	0.6	-0.4	-1.5
Neuroticism (Nagel 2018)	1.3	3.0	8.1	-2.8	2.0	0.6	2.7	1.1	-0.2	-0.3
Fasting Glucose	1.3	1.6	3.4	0.9	1.1	1.2	1.9	1.2	1.5	0.7
Had other major operations	1.3	1.6	6.5	0.2	0.4	0.6	2.6	0.9	1.6	0.9
Medication: Cholesterol lowering	1.3	2.1	4.4	-0.2	-1.1	2.1	1.5	1.4	1.7	1.4
High cholesterol (Self-reported)	1.3	2.2	5.1	0.1	-1.3	2.3	1.6	1.7	1.7	0.7
Respiratory disease	1.2	2.7	6.4	-2.5	1.9	-0.4	2.5	1.4	-0.3	-0.9
Hand grip strength (left)	1.2	3.3	6.6	1.0	-1.0	2.6	2.4	1.7	2.3	0.3
Relative age of first facial hair	1.2	2.4	5.5	-0.3	-1.5	-1.5	-2.3	-2.0	-1.7	-0.5
Average weekly red wine intake	1.2	1.7	5.1	-0.0	0.4	-2.3	-1.5	-1.6	-1.2	-0.9
Asthma (self-reported)	1.2	2.3	6.2	-2.5	1.7	-0.6	1.8	0.4	-0.9	-1.5
Commuting to job workplace: Public transport	1.2	1.4	3.6	-0.1	-0.2	-1.3	-1.9	-1.4	-1.1	-1.2
Ovarian Cancer	1.1	1.5	3.0	-0.8	0.3	-1.5	-0.7	-1.3	-1.7	-1.5
HbA1C	1.1	1.3	6.0	-0.1	-2.5	-0.1	-0.5	-0.4	0.5	1.4
Triglycerides	1.1	1.7	4.0	0.1	-0.8	2.0	1.3	0.6	1.8	1.5
Neuroticism	1.1	2.6	8.4	-1.6	1.7	1.0	2.9	1.9	0.4	0.0
Sensitivity / hurt feelings	1.1	2.0	6.5	-0.4	1.6	1.5	2.5	1.2	0.7	0.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.9	1.6	-0.2	0.9	1.0	1.7	1.1	0.8
Number of incorrect matches in round	1.1	1.7	3.6	-1.2	1.5	-1.2	-0.2	-0.7	-1.7	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	4.0	-0.7	1.6	0.7	2.0	1.0	0.4	-0.4
Loud music exposure frequency	1.1	1.2	4.5	0.6	-2.1	0.5	-0.6	-0.1	0.8	1.4
Number of full brothers	1.1	1.4	3.4	-0.3	0.3	1.7	1.8	1.6	0.7	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.7	-1.4	0.8	-0.8	-0.5	-1.1	-1.1	-1.6
Loneliness, isolation	1.1	1.6	4.0	0.5	-0.7	2.0	1.1	0.6	1.4	1.6
Guilty feelings	1.1	1.7	3.3	-1.6	1.7	-0.5	1.1	0.6	-1.1	-1.8
Tinnitus: Yes, now most or all of the time	1.1	1.2	2.5	1.5	-0.4	1.4	0.7	0.9	1.6	0.7
Arm fat-free mass (left)	1.1	5.7	10.2	2.0	-3.2	2.6	0.3	1.5	2.9	2.8
Myopia	1.1	1.5	5.0	2.2	-0.5	0.6	-0.7	1.3	1.2	1.2
Worry (Nagel 2018)	1.0	2.2	5.7	-2.4	1.7	-0.3	2.2	1.0	-0.5	-0.7
Age at First Birth	1.0	1.4	5.1	1.9	-0.1	-0.6	-2.3	-0.9	-0.1	-0.2
HDL Cholesterol	1.0	1.7	3.3	-1.1	0.9	-1.5	-0.7	-0.9	-1.8	-1.8
Medication for hormone replacement therapy	1.0	1.2	5.2	2.3	-0.8	-0.2	-0.9	0.6	0.9	0.6
Medication: Atenolol	1.0	1.3	2.8	-1.1	0.1	-0.9	-1.0	-0.5	-1.7	-1.6
Chronic bronchitis/emphysema (father)	1.0	1.2	3.5	0.1	1.1	1.3	1.9	1.1	0.4	0.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.2	-1.1	-1.5	-0.6	-1.4	-1.5	-1.1	-0.1
Medication: Paracetamol	1.0	1.7	2.8	1.7	-0.8	1.2	1.4	1.7	1.4	0.6
Medication: Amlodipine	1.0	1.5	4.5	-2.1	0.7	1.0	2.0	0.4	0.5	-0.0
Arm fat-free mass (right)	1.0	5.3	11.2	1.7	-3.3	2.5	0.2	1.5	2.7	2.7
Eye problems/disorders: None of the above	1.0	1.1	2.4	1.0	-0.7	1.5	0.2	0.6	1.3	1.3
Mean time to correctly identify matches	1.0	2.0	3.9	-2.0	1.7	-1.5	-0.1	-0.8	-1.8	-0.9
Arm predicted mass (right)	1.0	5.0	10.5	1.7	-3.2	2.6	0.2	1.3	2.7	2.5
Leg fat-free mass (right)	1.0	5.2	11.4	2.2	-3.4	2.0	-0.8	1.3	2.2	3.0
Commuting to job workplace: Walk	1.0	1.0	3.2	1.8	-1.3	0.1	-1.0	0.4	0.8	0.6
Mineral and other dietary supplements	1.0	1.3	3.9	0.2	-0.0	0.8	2.0	1.4	1.2	1.1
Osteoarthritis (self-reported)	1.0	1.3	3.0	1.1	1.1	0.9	1.4	1.7	1.0	-0.0
Leg predicted mass (right)	1.0	5.4	11.7	2.2	-3.4	2.0	-0.9	1.3	2.3	3.1
Hearing aid user	1.0	1.1	2.8	0.5	-0.6	1.6	0.7	0.8	1.7	0.9
Alzheimer’s Disease (including proxy)	0.9	1.3	2.5	-0.5	1.1	-1.6	-0.7	-1.2	-1.5	-1.0
Coronary Artery Disease (CAD)	0.9	1.1	3.5	-0.3	0.3	1.6	1.9	0.7	1.1	0.0
Leg fat-free mass (left)	0.9	4.7	11.9	1.9	-3.4	1.8	-0.9	1.0	2.1	2.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	4.2	-1.0	0.3	0.7	1.7	2.0	0.8	0.1
Asthma	0.9	1.8	6.0	-2.4	1.2	-0.3	1.9	0.3	-0.5	-1.0
Standing height	0.9	8.6	27.2	2.8	-5.2	-0.5	-4.2	-1.8	0.5	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.1	-0.9	0.2	1.8	1.7	1.2	1.0	0.8
Neck or shoulder pain in last month	0.9	1.2	3.1	0.8	-0.0	1.3	1.3	1.8	1.0	0.7
Leg pain on walking	0.9	1.2	3.4	1.3	-1.2	1.8	0.4	0.5	1.1	0.4
Hypertension (Self-reported)	0.9	2.5	6.1	-2.5	1.7	0.9	2.1	1.1	-0.2	-1.4
Breast cancer (self-reported)	0.9	1.1	2.2	1.5	-0.8	1.0	0.6	0.8	1.2	1.1
Medication: Paracetamol	0.9	1.3	2.2	1.4	-0.6	1.1	1.5	1.4	1.3	0.5
Alcohol drinker status: Never	0.9	1.1	1.9	-0.8	0.6	-1.0	-1.0	-1.1	-1.3	-1.4
Basal metabolic rate	0.9	5.1	11.9	1.9	-3.5	2.3	-0.5	1.1	2.4	2.8
Arm predicted mass (left)	0.9	4.7	8.3	1.8	-2.9	2.5	0.3	1.5	2.6	2.4
Reaction Time	0.8	1.5	2.3	-1.4	1.4	-1.2	-0.2	-0.8	-1.5	-1.4
LDL Cholesterol	0.8	1.2	4.2	0.6	-2.1	1.0	-0.3	0.0	1.1	1.1
Lupus	0.8	1.2	2.6	0.5	0.9	0.1	-1.3	-0.9	-1.5	-1.6
High blood pressure	0.8	2.1	6.6	-2.6	1.2	0.9	1.7	0.8	-0.4	-1.5
Leg predicted mass (left)	0.8	4.3	11.0	1.8	-3.3	1.8	-0.9	1.0	2.0	2.7
Hearing difficulty/problems with background noise	0.8	1.3	6.0	-2.4	-0.9	-0.9	0.1	-0.6	-1.2	0.1
Allergy	0.8	1.8	5.0	2.2	-1.6	0.8	-1.6	-0.8	0.2	0.8
Illnesses of siblings	0.8	1.2	2.7	1.2	-0.8	-1.2	-1.6	-1.3	-0.5	0.2
Neuroticism score	0.8	1.6	4.5	-1.4	1.6	0.8	2.1	1.2	-0.3	-0.6
Happiness	0.8	1.0	2.5	0.3	-1.6	-0.0	-1.4	-1.1	0.1	1.1
Noisy workplace	0.8	1.0	2.7	-0.7	-0.4	1.1	1.7	1.2	0.7	0.8
Hair/balding pattern: Pattern 4	0.8	1.8	7.1	-2.7	0.7	-1.3	-0.0	0.3	-1.0	-1.7
High blood pressure (siblings)	0.8	1.2	3.2	-1.8	1.2	0.2	1.3	0.6	-0.4	-1.1
Pulse wave peak to peak time	0.8	0.9	2.3	0.0	-1.5	-0.9	-1.2	-1.2	-0.7	-0.2
Medication: Seretide 50 evohaler	0.8	0.9	3.1	-0.1	0.8	0.5	1.8	1.2	1.0	-0.2
Had major operations	0.8	0.9	2.5	-1.0	-0.3	-0.4	-0.8	-1.6	-1.1	-0.9
Crohns Disease (2017)	0.7	1.6	7.3	-1.5	0.6	-0.0	2.7	0.9	0.6	-0.3
Mean Putamen Volume	0.7	0.8	2.7	-1.6	-0.9	-1.1	0.1	-0.2	-0.6	-0.8
Primary Biliary Cirrhosis	0.7	1.0	2.7	-0.5	1.4	-0.6	0.2	-0.9	-1.0	-1.6
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.7	0.3	-0.3	1.3	1.0	1.1	1.2	1.0
Relative age voice broke	0.7	1.0	1.8	-0.1	-0.6	-1.2	-1.2	-1.2	-1.3	-0.8
Nervous feelings	0.7	1.3	4.6	-0.7	2.1	-0.1	0.8	0.7	-0.8	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.7	-2.4	0.9	-0.4	1.8	-0.1	-0.5	-1.2
Medication: Ramipril	0.7	0.9	1.8	-1.1	-0.4	1.0	1.3	0.3	0.9	1.1
Impedance of arm (right)	0.7	3.3	9.9	1.0	-0.8	-2.3	-3.1	-2.0	-1.7	-0.4
Worrier / anxious feelings	0.7	1.4	4.4	-2.1	1.0	0.1	1.6	1.1	-0.2	-0.6
Pulse wave Arterial Stiffness index	0.7	0.9	1.7	0.4	1.1	1.0	1.0	1.3	0.9	0.4
Comparative height size at age 10	0.7	4.0	11.7	1.4	-3.4	-0.6	-3.1	-1.3	-0.0	1.7
Knee pain experienced in last month	0.7	1.1	3.5	0.7	0.2	1.3	1.0	1.9	1.0	-0.3
Whole body fat-free mass	0.7	3.8	10.6	1.4	-3.3	1.9	-0.6	0.8	2.0	2.3
Diabetes diagnosed by doctor	0.7	1.1	3.3	-0.8	1.4	0.8	1.8	1.1	0.2	0.1
Whole body water mass	0.7	3.8	10.0	1.5	-3.2	1.9	-0.5	0.9	2.1	2.3
Ever depressed for a whole week	0.7	0.8	2.9	-1.2	1.7	-0.2	0.3	-0.2	-0.4	-1.1
Supplements: Calcium	0.7	0.8	1.9	-0.1	-0.5	-1.2	-1.4	-0.9	-1.0	0.3
Depression (Nagel 2018)	0.6	1.0	3.1	-1.1	0.5	0.7	1.8	1.2	0.6	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	5.3	0.5	-0.5	-1.3	-2.3	-0.9	-1.4	-0.6
Crohns Disease (2012)	0.6	0.9	1.8	-0.7	-0.6	0.8	1.3	0.8	1.0	1.2
Height	0.6	12.4	32.8	3.9	-5.7	-0.3	-5.4	-2.2	0.6	2.0
Allergy or Eczema	0.6	1.6	5.1	-1.2	2.2	-0.9	1.7	-0.2	-0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.7	0.3	1.6	0.1	0.4	0.0	-0.6	-1.2
Pack years adult smoking proportion	0.6	0.9	3.4	-1.8	-0.2	-1.0	0.3	0.2	-1.1	-0.6
Hand grip strength (right)	0.6	1.5	2.8	1.0	-0.3	1.5	1.5	1.5	1.7	-0.3
Current tobacco smoking	0.6	0.9	1.8	-1.3	0.7	-1.4	0.4	0.0	-1.0	-1.1
Supplements: Glucosamine	0.6	0.8	3.4	-0.1	1.9	-0.2	0.6	0.3	-0.7	-0.9
Sitting height	0.6	4.5	15.4	1.4	-3.9	0.5	-2.9	-1.0	1.0	2.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.8	0.0	1.7	0.1	1.3	0.6	-0.5	-0.9
Hip circumference	0.6	2.5	7.5	0.9	-2.7	1.4	-0.7	0.7	1.4	2.0
Impedance of arm (left)	0.6	2.8	8.6	1.7	-1.4	-1.8	-2.9	-1.4	-1.0	0.3
Tense / ‘highly strung’	0.6	1.0	2.5	-1.6	1.0	0.2	1.5	0.3	-0.6	-0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.4	0.9	-0.8	-1.3	-1.9	0.1	-0.9	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.4	-0.7	-1.0	0.7	-0.3	0.4	0.6	1.6
Shortness of breath walking on level ground	0.6	0.7	3.4	-1.8	0.1	-0.2	0.9	-0.5	-0.3	-0.6
Emphysema/chronic bronchitis	0.6	0.6	1.3	-1.1	1.0	0.6	0.8	0.8	0.6	0.5
Medication for pain relief, constipation, heartburn	0.6	1.1	2.5	-0.7	1.3	-1.6	-0.4	-1.1	-1.1	-0.1
Mood swings	0.6	1.0	3.5	-1.9	-0.0	0.9	1.4	0.8	0.1	0.3
Friendships satisfaction	0.6	0.7	3.7	0.3	-1.9	0.5	-0.6	-0.2	0.3	0.6
Medication: Bendroflumethiazide	0.6	0.9	3.1	-1.8	0.7	0.1	1.2	0.4	-0.6	-0.9
Average weekly beer plus cider intake	0.6	0.8	2.4	0.4	-0.3	0.4	0.1	1.3	1.1	1.5
Fractured/broken bones in last 5 years	0.6	0.8	2.5	1.6	0.4	0.7	0.8	1.0	0.6	0.5
Vascular/heart problems diagnosed by doctor	0.6	1.7	5.6	2.4	-0.9	-1.0	-1.4	-0.5	0.4	1.3
Neuroticism (2016)	0.5	0.8	2.4	-0.5	0.8	-0.0	1.6	1.4	0.3	-0.1
Blood Platelet Count	0.5	6.1	15.8	0.0	1.9	2.4	4.0	3.7	2.0	0.1
Medication: Metformin	0.5	0.6	1.1	0.8	1.1	1.0	1.0	0.5	0.6	0.4
Diabetes (mother)	0.5	0.7	3.0	0.3	-0.0	1.7	0.6	1.0	0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	4.3	-1.1	0.4	0.4	2.1	1.1	0.5	-0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.4	0.3	0.9	-0.9	-0.9	-1.2	-0.5	0.1
Medication: Simvastatin	0.5	0.7	1.7	-0.5	1.0	0.8	1.0	1.3	0.4	-0.6
Trunk fat-free mass	0.5	2.6	8.8	1.0	-3.0	1.4	-0.5	0.4	1.7	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	-0.9	1.3	0.7	1.5	0.5	0.2	-0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.6	0.8	-1.0	-1.2	-1.9	-1.0	-0.4	0.2
Mouth/teeth dental problems: Dentures	0.5	0.8	2.3	-0.6	1.1	1.1	1.5	0.7	0.3	-0.1
Medication: Lansoprazole	0.5	0.6	1.4	-1.2	0.5	-0.9	-0.0	-0.9	-0.7	-0.6
Trunk predicted mass	0.5	2.6	9.0	1.0	-3.0	1.4	-0.6	0.4	1.7	1.8
Exposure to tobacco smoke at home	0.5	0.6	1.3	-0.5	-0.8	0.6	1.0	-0.0	0.7	1.1
Gout (self-reported)	0.5	0.7	2.3	-0.4	0.0	0.5	1.5	0.1	0.8	1.1
Comparative body size at age 10	0.5	1.4	3.0	-0.5	-0.1	1.3	1.3	1.2	1.2	1.7
Worry too long after embarrassment	0.5	0.9	2.0	-0.4	0.4	-1.1	-1.4	-0.5	-1.3	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.2	0.1	1.1	0.1	0.7	1.5	0.1	-0.2
Qualifications: nursing, teaching	0.5	0.7	2.2	-0.8	-1.5	-0.6	-0.8	-0.7	0.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.5	-0.4	-0.4	-0.3	-1.6	-0.3	-1.0	-0.8
Osteoporosis (self-reported)	0.5	0.6	1.8	0.1	-0.4	-0.4	-1.1	-1.3	-0.9	-0.6
Risk taking	0.5	0.7	2.2	-0.6	-1.5	0.3	0.9	0.6	0.6	0.7
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.2	-0.2	-1.0	0.8	-0.3	0.4	1.1	0.7
Heart disease (siblings)	0.5	0.6	1.5	-0.7	0.1	0.9	1.2	0.9	0.7	0.5
Pack years of smoking	0.5	0.8	3.2	-1.8	0.2	-0.9	0.4	0.3	-1.1	-0.4
Blood White Count	0.4	2.6	7.0	-2.6	1.7	-1.4	0.7	-0.2	-1.5	-2.0
Smoking Status	0.4	1.1	4.2	-2.1	0.5	-1.2	-0.5	-0.4	-0.9	-0.5
Cardiovascular Disease	0.4	1.5	6.3	-2.5	0.7	0.5	1.0	0.2	-0.3	-1.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.4	1.5	0.3	0.6	0.3	0.7	0.4	0.3
Townsend deprivation index at recruitment	0.4	0.6	1.7	0.5	0.4	0.7	1.3	1.3	0.3	0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.3	-1.1	1.4	-0.6	1.5	0.4	0.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.0	0.5	0.8	-0.8	-0.2	0.3	-0.6	-1.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	-0.9	1.3	-0.1	-0.1	0.3	-0.6	-0.9
Fluid intelligence score	0.4	0.9	3.3	1.2	-0.6	-0.7	-1.8	-0.4	-0.5	-0.5
Time employed in main current job	0.4	0.4	1.0	0.3	-1.0	0.7	0.4	0.6	0.7	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	2.2	-0.2	-1.5	0.5	-0.1	0.5	0.4	0.5
Length of working week for main job	0.4	0.5	1.4	-0.1	-0.5	-0.1	1.2	0.6	0.9	0.7
Birth weight of first child	0.4	0.7	1.7	1.0	-1.3	0.4	0.1	-0.1	0.9	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.2	-1.5	-0.8	-0.3	-0.1	-0.6	-0.4	0.3
Migraine (self-reported)	0.4	0.4	1.5	1.0	0.2	0.7	0.1	0.2	0.2	-1.2
Number of full sisters	0.4	0.5	1.8	-0.0	-0.7	-0.9	-1.3	-0.3	-0.3	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.1	-1.0	0.9	-0.2	0.6	0.0	-0.5	-1.1
Back pain experienced in last month	0.4	0.6	1.7	-0.1	-0.6	0.7	1.3	0.5	1.1	0.0
Medication: Gliclazide	0.4	0.4	1.9	-1.4	-0.1	-0.4	-0.2	-0.2	-0.6	-0.6
Smoking status: Current	0.4	0.7	1.5	-1.1	0.6	-1.2	0.3	0.1	-0.8	-0.9
Unable to work because of sickness or disability	0.4	0.5	1.7	0.9	1.3	0.5	0.7	0.2	0.2	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.1	-1.0	-0.2	0.3	-0.3	-1.4	-0.3	-0.3
Impedance of whole body	0.4	2.1	5.7	1.4	-1.2	-1.7	-2.4	-1.3	-0.8	-0.1
Major Depression (MDD)	0.3	0.3	1.0	-0.4	0.3	0.3	0.9	-0.1	-0.3	-1.0
Hypothyroidism (self reported)	0.3	0.7	1.9	1.3	-0.8	-0.6	-1.4	0.5	-0.3	0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.5	0.4	0.4	0.9	0.7	0.7	0.5
Ever had hysterectomy (womb removed)	0.3	0.3	1.2	1.1	0.7	0.3	0.5	0.5	0.2	0.0
Impedance of leg (right)	0.3	1.7	3.1	0.0	-0.6	-1.6	-1.5	-1.8	-1.1	-1.4
Average weekly fortified wine intake	0.3	0.4	1.3	0.1	-1.1	-0.1	-0.2	-0.3	0.6	1.0
Taking other prescription medications	0.3	0.5	1.3	0.1	0.1	1.1	0.8	0.9	0.8	0.5
Stomach or abdominal pain in last month	0.3	0.4	1.1	0.2	0.1	0.9	1.0	0.3	0.5	-0.3
Alcohol usually taken with meals	0.3	0.5	1.4	-0.9	-0.6	-0.3	-0.4	-1.2	-0.6	-0.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	1.1	0.5	-0.6	-0.4	0.1	-0.3	-0.6
Had menopause	0.3	0.4	1.2	-0.7	0.5	-1.1	0.5	-0.5	-0.6	-0.0
Financial difficulties in last 2 years	0.3	0.4	1.6	-0.6	-0.5	-0.3	-0.2	-0.2	-0.6	-1.3
Diabetes (self-reported)	0.3	0.5	1.4	-0.9	0.9	0.2	1.2	0.6	-0.1	-0.3
Falls in the last year	0.3	0.4	1.1	-0.0	-1.0	-0.4	-0.5	0.6	0.5	0.9
Number of live births	0.3	0.5	1.9	0.2	1.4	0.2	1.0	0.4	0.3	0.3
Glaucoma (self-reported)	0.3	0.4	0.7	-0.6	0.5	-0.9	-0.4	0.3	-0.7	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	1.8	-1.3	-0.7	-0.7	0.1	-0.5	-0.5	-0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	-0.1	-0.8	-0.2	-1.0	-0.5	0.3	0.9
Medication: Omeprazole	0.3	0.3	0.7	0.8	-0.1	0.3	-0.6	0.7	0.7	-0.4
Alcohol intake frequency.	0.3	0.7	1.5	-0.4	1.2	1.0	1.1	0.8	-0.0	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.8	0.2	-0.7	0.3	0.2	0.4	0.8	0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	0.3	0.1	-1.2	-0.9	-0.7	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.2	1.4	-1.5	0.5	-0.2	-0.4	0.3	0.1
Medication: Aspirin	0.3	0.4	1.2	0.0	-1.0	1.1	-0.4	0.1	0.5	0.2
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	-0.5	-0.3	0.8	1.2	0.8	0.7	0.4
Medication: Blood pressure	0.3	0.5	1.4	-0.5	0.9	0.7	0.3	0.2	-0.5	-1.2
Diastolic blood pressure, automated reading	0.3	0.9	2.6	-0.5	-0.4	0.1	1.6	1.4	0.6	0.9
Cholesterol lowering medication	0.3	0.4	0.8	-0.7	-0.6	0.7	0.3	0.8	-0.2	-0.9
Bipolar Disorder (2018)	0.2	0.3	1.2	-0.5	-0.4	-0.4	0.6	1.1	0.2	0.1
Hair Pigment	0.2	7.0	11.1	-1.3	-0.1	-2.8	-2.9	-3.3	-3.0	-3.3
Number of treatments/medications taken	0.2	0.4	1.1	0.1	-0.7	1.1	0.5	0.7	0.6	0.4
Average weekly spirits intake	0.2	0.2	1.0	-0.1	0.6	-1.0	-0.4	-0.0	-0.4	-0.1
Diabetes (father)	0.2	0.3	1.4	0.5	-0.2	-0.1	-1.2	-0.3	-0.4	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.7	-1.3	0.4	0.1	0.5	0.1	-0.2	-0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.0	0.8	0.5	0.4	0.4	0.3	-0.3
Heart attack	0.2	0.3	1.2	-0.4	-0.4	0.7	-0.1	-1.1	0.2	0.2
Hair/balding pattern: Pattern 3	0.2	0.4	1.2	-0.7	0.6	0.2	0.3	-1.1	-0.5	-0.3
Breastfed as a baby	0.2	0.2	0.6	-0.4	-0.7	-0.3	-0.3	-0.8	-0.1	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	-0.8	-0.8	0.1	-0.1	-0.0	-0.1	0.7
Medication: Ibuprofen	0.2	0.3	1.6	-0.3	-1.3	0.1	-0.4	-0.2	-0.1	-0.1
Medication: Allopurinol	0.2	0.2	1.0	-0.3	0.5	0.1	1.0	0.2	0.2	-0.0
Family relationship satisfaction	0.2	0.3	0.8	0.9	0.4	0.5	-0.0	0.5	0.5	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.2	-1.1	0.5	-0.1	0.4	0.1	0.0	0.3
Medication: Aspirin	0.2	0.2	1.1	0.1	-0.6	1.0	-0.4	0.0	0.3	-0.2
Ever had bowel cancer screening	0.2	0.3	0.9	-0.9	0.5	-0.4	0.8	0.0	0.1	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.4	0.1	0.5	0.4	0.6	0.7	0.4
Medication for cholesterol	0.2	0.3	0.9	-0.7	-0.0	-0.6	0.2	-0.9	-0.2	0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.7	0.2	-0.8	0.6	-0.3	0.2	0.2	0.7
Average weekly champagne plus white wine intake	0.2	0.2	0.9	0.9	0.3	0.5	0.5	0.2	0.0	-0.1
Financial situation satisfaction	0.2	0.3	0.7	-0.7	0.2	-0.4	0.5	-0.9	-0.2	-0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.7	0.7	-0.2	-0.0	0.0	-0.5	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.1	0.1	-0.4	-0.2	-1.0	-0.6	-0.1	0.4
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.6	-0.1	0.8	-0.2	0.1	0.7	-0.3
Ever smoked	0.2	0.4	1.0	0.1	-0.4	-1.0	-0.8	0.3	0.3	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.7	0.2	0.4	-0.0	0.2	0.8	0.2	-0.8
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.5	0.4	0.5	-0.1	-0.3	0.2	0.2
Rheumatoid Arthritis	0.1	0.2	0.8	0.7	-0.2	0.2	0.1	0.9	0.1	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	-0.4	0.2	0.4	0.7	0.3	0.3	0.0
Blood Eosinophil Count	0.1	0.9	3.6	-1.9	-0.2	-0.4	0.2	0.2	-1.5	-0.7
Blood Red Count	0.1	1.1	3.0	1.0	-0.2	1.7	1.1	1.1	1.1	0.5
Heel T-Score	0.1	0.7	2.7	-0.4	0.9	0.5	1.6	0.7	0.7	0.1
Chronotype (morning person)	0.1	0.3	1.2	-1.1	0.3	-0.0	0.8	0.0	0.1	0.5
Tanning	0.1	1.5	2.8	0.4	-0.0	1.7	1.7	1.2	1.7	0.5
Age when periods started (menarche)	0.1	0.4	1.6	1.3	-0.7	0.6	-0.1	-0.0	0.2	0.0
Impedance of leg (left)	0.1	0.7	1.3	0.9	-0.6	-0.9	-1.1	-0.9	-0.4	-0.6
Past tobacco smoking	0.1	0.1	0.5	0.3	-0.2	0.5	0.7	-0.1	0.1	-0.2
Mouth/teeth dental problems	0.1	0.1	0.6	0.1	-0.1	-0.7	0.3	-0.3	0.0	-0.5
Father’s age at death	0.1	0.2	0.6	-0.2	-0.6	-0.1	0.2	-0.2	0.5	0.8
Lung cancer (father)	0.1	0.2	0.8	-0.3	-0.9	0.2	-0.3	0.2	-0.2	0.3
Pulse wave reflection index	0.1	0.2	0.5	-0.7	0.4	0.0	0.6	-0.2	0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	-0.0	-0.6	-0.4	-0.8	0.3	0.2	0.2
Headache pain in last month	0.1	0.2	0.9	0.1	-0.3	1.0	0.5	0.2	-0.1	-0.2
Birth weight	0.1	0.2	0.9	1.0	-0.5	0.2	-0.3	-0.3	0.2	-0.2
Illnesses of father: Heart disease	0.1	0.2	0.5	0.4	-0.1	0.4	0.7	0.6	0.4	-0.3
Smoking status: Previous	0.1	0.2	0.8	-0.1	-0.4	0.1	-0.9	0.1	0.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	0.8	-0.2	0.6	-0.7	-0.1	0.1	0.3
Number of operations (self-reported)	0.1	0.2	0.9	-0.3	0.4	0.5	0.9	-0.1	0.4	0.1
Alcohol drinker status: Previous	0.1	0.2	0.6	-0.3	0.8	0.1	-0.2	0.2	-0.3	-0.5

Hub : Genes

ARHGAP12

Models

Trait associations