Hub : Genes

KIF5B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.1690 0.0780 9.5e-03 0.096 NA 0.020 NA 0.050 5.1e-04 NA 7.2e-02 NA 1.0e-02
2 GTEx Muscle Skeletal 0.0928 0.0315 3.5e-05 0.039 NA 0.038 NA 0.049 9.0e-05 NA 1.1e-04 NA 1.2e-05
3 GTEx Skin Not Sun Exposed Suprapubic 0.1450 0.0570 2.4e-03 0.030 NA 0.054 NA 0.035 9.1e-03 NA 6.5e-04 NA 4.9e-03
4 GTEx Testis 0.5210 0.0760 1.7e-16 0.343 NA 0.338 NA 0.336 6.2e-16 NA 1.1e-15 NA 1.3e-15
5 METSIM Adipose 0.0658 0.0210 8.1e-07 0.059 0.052 0.074 0.059 0.076 3.6e-09 2.8e-08 3.4e-11 3.1e-09 1.5e-11
6 ROSMAP Brain Pre-frontal Cortex 0.0580 0.0226 1.3e-03 0.019 0.026 0.016 0.029 0.031 1.3e-03 2.1e-04 3.1e-03 1.0e-04 5.6e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.4 0.9 0.8 -0.2 -0.9 0.8 0.7 0.0
Bipolar Disorder or Schizophrenia 0.8 1.9 6.2 -1.1 -2.5 -1.0 1.3 1.0 -0.6
Depressed Affect (Nagel 2018) 1.1 2.3 5.5 0.4 -0.5 0.7 2.3 1.3 -2.4
Depression (Nagel 2018) 1.1 1.6 4.5 1.3 0.9 0.1 2.1 1.0 -1.3
Intelligence (Savage-Jansen 2018) 1.6 5.0 16.2 -1.0 -0.5 -0.7 -3.2 -1.4 4.0
Neuroticism (Nagel 2018) 2.0 4.8 10.3 2.4 1.5 0.8 2.6 1.7 -3.2
Schizophrenia (2018) 1.3 2.6 9.4 -2.0 -3.1 -0.6 0.8 0.8 -0.8
Schizophrenia vs Biploar Disorder 1.2 1.5 4.5 -2.1 -2.1 -0.0 -0.2 -0.3 -0.4
Worry (Nagel 2018) 1.3 2.7 7.5 2.0 1.2 -0.1 1.8 0.2 -2.7
Alzheimer’s Disease (in mother) 0.9 1.0 2.1 0.8 1.5 -0.4 -0.3 -1.4 -1.0
Alzheimer’s Disease (in father) 0.0 0.0 0.0 -0.2 -0.0 0.1 -0.1 -0.1 0.1
Alzheimer’s Disease (including proxy) 0.4 0.5 1.5 0.2 1.1 -0.4 -0.2 -1.2 -0.5
Crohns Disease (2017) 1.8 4.0 8.3 1.8 1.4 0.7 2.9 2.7 -1.7
Irritable Bowel Disease (IBD) 2.9 7.0 18.1 1.9 0.9 1.1 4.3 3.8 -2.0
Ulcerative Colitis (UC) 1.8 3.5 10.1 1.1 -0.0 0.7 3.2 2.8 -1.1
Major Depression (MDD) 0.6 0.7 1.7 1.3 0.9 -0.4 0.3 1.1 -0.7
Reaction Time 1.1 2.1 5.0 1.8 2.2 1.6 0.3 -0.1 -1.2
Verbal and Numeric Reasoning (VNR) 1.4 3.4 8.9 -1.5 -1.3 -0.0 -3.0 -2.3 1.6
Breast Cancer 2.0 4.7 11.4 3.1 3.4 1.0 -0.2 -1.1 -2.2
Ovarian Cancer 1.2 1.6 3.0 1.4 1.4 0.0 -0.7 -1.4 -1.7
Prostate Cancer 1.2 1.6 4.8 0.2 -0.8 0.5 2.2 1.9 -0.6
Age at First Birth 2.0 2.9 7.6 -1.4 -0.7 -0.8 -1.9 -1.7 2.8
Bipolar Disorder (2011) 0.5 0.5 1.5 -0.2 -0.8 0.3 0.1 1.2 0.8
Body Mass Index (BMI) (2010) 2.3 3.1 5.4 1.4 1.0 2.1 2.3 2.0 -1.4
Coronary Artery Disease (CAD) 3.4 4.1 8.4 1.9 1.0 1.5 2.9 2.9 -1.1
Crohns Disease (2012) 0.4 0.6 2.1 -0.2 -0.3 0.7 1.4 0.8 -0.7
Mean Putamen Volume 0.4 0.4 0.6 0.8 0.6 0.5 0.6 -0.6 -0.8
Fasting Glucose 0.8 1.0 3.3 0.2 0.3 -0.1 1.8 0.6 -1.4
HbA1C 1.8 2.0 4.1 -1.7 -1.8 -2.0 -0.6 -1.0 -0.4
HDL Cholesterol 0.5 0.9 2.7 1.3 1.6 -0.7 -0.1 -0.7 -0.1
LDL Cholesterol 0.8 1.3 3.2 -1.8 -1.5 -1.0 -0.2 0.5 1.0
Lupus 1.0 1.6 4.5 -0.8 -0.1 -0.1 -2.1 0.0 2.1
Neuroticism (2016) 1.2 1.7 3.2 1.7 1.2 1.0 1.8 0.8 -1.0
Primary Biliary Cirrhosis 1.4 2.1 6.3 2.0 2.5 0.8 0.7 0.7 -0.5
Rheumatoid Arthritis 0.5 0.7 1.7 -0.9 -0.9 -0.9 -0.3 -1.3 0.1
Schizophrenia (2014) 1.7 3.7 13.1 -2.4 -3.6 -1.1 1.0 1.1 -0.5
Triglycerides 1.0 1.7 4.5 -0.1 -0.9 2.1 0.9 1.6 -1.2
Type 2 Diabetes (T2D) (2012) 0.2 0.2 1.3 -0.1 -0.1 0.3 0.0 -0.0 -1.1
Ulcerative Colitis 2.0 2.9 7.9 0.2 -0.6 1.1 2.8 2.7 -0.8
Blood Eosinophil Count 0.1 0.9 2.5 1.1 0.7 0.9 0.5 -0.6 -1.6
Blood Platelet Count 1.0 11.2 23.8 3.2 1.7 3.3 4.3 4.9 -0.5
Blood Red Count 0.1 0.6 2.2 -0.3 -0.3 -0.0 1.2 1.5 0.4
Blood White Count 0.2 1.8 3.8 1.9 1.7 1.6 -0.5 0.4 -0.9
Heel T-Score 0.4 3.1 6.1 1.3 1.5 1.3 2.2 1.5 -2.5
BMI 0.7 4.3 10.8 0.7 -0.8 0.9 3.3 2.4 -2.7
Height 1.2 23.7 39.7 -6.3 -5.0 -5.3 -3.3 -3.5 5.2
Waist Hip Ratio (WHR) 1.3 5.8 13.0 1.2 0.5 2.4 3.6 3.3 -1.9
Systolic Blood Pressure 4.9 24.7 55.7 7.5 6.8 1.3 5.0 3.2 -3.2
Smoking Status 0.2 0.4 1.0 0.7 0.7 1.0 0.1 0.2 0.6
Allergy or Eczema 1.1 3.0 8.3 1.8 1.8 -0.6 1.7 0.3 -2.9
Cardiovascular Disease 1.9 6.2 11.6 3.4 2.4 0.4 2.9 3.3 -0.8
Hypothyroidism (self reported) 2.3 5.3 10.8 -2.6 -1.9 0.3 -3.3 -2.5 2.0
Respiratory disease 1.5 3.4 10.0 2.1 1.0 0.6 2.1 -0.2 -3.2
Type 2 Diabetes (T2D) (2018) 1.2 2.3 5.4 1.2 0.4 1.3 1.8 2.3 -1.2
Lung FEV1/FVC ratio 0.7 3.5 7.1 2.0 2.7 1.0 -1.8 -2.4 -0.4
Lung FVC 1.0 4.9 13.1 -0.2 1.8 -0.0 -3.6 -2.9 2.2
Neuroticism 1.5 3.5 6.9 2.1 1.2 1.1 2.6 1.2 -2.4
Chronotype (morning person) 0.6 1.3 3.0 0.9 0.6 1.7 0.5 0.8 -1.7
Hair Pigment 0.1 2.4 3.9 0.6 1.8 -0.0 -2.0 -1.9 1.7
Tanning 0.2 2.2 4.9 1.4 0.8 -0.9 2.2 1.7 -1.4
Hand grip strength (left) 1.9 4.9 12.9 1.8 0.6 -0.3 3.6 3.6 -0.1
Number of treatments/medications taken 0.3 0.6 1.8 -0.7 -1.1 -1.4 -0.1 0.4 0.4
Average weekly spirits intake 0.9 1.2 3.5 -0.8 -0.8 -0.7 -1.3 -1.9 0.0
Sensitivity / hurt feelings 2.0 3.4 4.4 1.9 1.6 1.3 2.1 2.0 -2.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.4 -0.3 -0.3 0.3 1.2 0.9 0.1
Hearing difficulty/problems: Yes 0.9 1.3 3.4 0.3 0.6 -1.3 -0.8 -1.8 -1.3
Relative age of first facial hair 1.0 2.1 6.8 -0.6 0.6 0.4 -2.6 -2.2 -0.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.4 -0.6 -0.6 0.4 -0.2 -0.4 -0.4
Ever used hormone-replacement therapy (HRT) 0.7 0.8 2.3 -1.5 -1.1 0.3 0.3 -0.0 1.2
Ever had hysterectomy (womb removed) 1.3 1.4 4.7 -1.0 -0.6 2.2 -1.4 -0.6 0.5
Systolic blood pressure, automated reading 3.4 9.8 18.9 4.3 3.4 1.8 3.7 2.3 -2.6
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 0.6 0.8 0.8 0.6 0.7 0.8 0.1
Angina 4.2 5.6 13.8 3.3 3.7 -0.2 1.5 2.3 -1.2
Medication for hormone replacement therapy 1.3 1.5 3.8 -1.6 -1.1 -1.2 -0.3 -0.3 2.0
Vitamin and mineral supplements 3.7 5.1 10.3 2.2 0.9 0.9 3.2 2.8 -2.3
Supplements: Zinc 2.7 2.9 4.2 -2.0 -1.4 -1.7 -1.9 -1.7 1.5
Medication: Co-codamol 0.6 0.7 1.8 0.7 1.2 0.1 -0.8 -1.4 0.4
Medication: Metformin 0.7 1.0 2.7 0.0 0.3 1.2 1.0 1.6 0.9
Diabetes (father) 0.5 0.6 1.6 -0.4 -0.2 0.4 -1.3 -0.6 1.2
Diabetes (mother) 0.1 0.1 0.3 -0.3 -0.4 0.1 0.5 0.3 0.4
Severe depression (siblings) 1.3 1.4 2.9 -0.2 -0.6 0.8 1.7 1.4 -1.6
Pack years adult smoking proportion 0.2 0.3 1.1 1.0 0.6 0.2 -0.2 0.5 -0.2
Impedance of leg (right) 0.2 1.0 1.9 0.2 0.8 0.1 -1.2 -1.4 1.3
Leg fat-free mass (left) 0.9 4.6 12.6 -3.3 -3.5 -1.8 -0.1 -0.8 0.7
Trunk fat percentage 2.1 8.3 25.4 -4.6 -5.0 -0.5 -1.0 -1.1 0.9
Hand grip strength (right) 0.6 1.7 4.2 1.0 0.4 0.6 2.0 2.1 -0.2
Townsend deprivation index at recruitment 1.0 1.4 4.2 0.7 0.6 2.0 0.9 1.5 0.4
Current tobacco smoking 0.5 0.7 1.6 1.1 1.3 1.1 -0.1 0.5 -0.2
Average weekly fortified wine intake 0.7 0.8 4.0 0.1 -0.4 -2.0 0.6 -0.4 0.0
Maternal smoking around birth 2.8 4.1 7.7 2.2 1.2 0.4 2.8 2.8 -1.7
Fed-up feelings 0.7 1.4 2.9 -1.0 -1.4 -0.4 1.7 1.5 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.4 0.8 0.6 -1.2 1.2 0.1 -0.7
Relative age voice broke 0.7 1.1 3.6 0.3 0.7 -0.5 -1.9 -1.5 0.1
Taking other prescription medications 1.1 1.7 6.1 -0.8 -1.3 -2.5 -0.3 -0.7 -1.1
Age when periods started (menarche) 0.1 0.2 0.7 -0.5 -0.1 -0.2 -0.1 0.3 0.9
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.5 -0.8 -0.9 1.2 -0.4 0.1 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 9.1 1.6 0.7 0.5 3.0 1.1 -2.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.4 -0.4 0.7 0.6 -1.2 -0.4 0.3
Qualifications: CSEs or equivalent 0.4 0.5 1.0 -0.5 -1.0 0.9 0.1 0.8 0.8
Serious illness, injury or assault to yourself 0.2 0.2 0.6 0.2 0.5 -0.2 0.6 -0.3 -0.8
High blood pressure 1.8 4.9 9.2 2.9 1.9 0.3 3.0 2.7 -1.1
Hayfever, allergic rhinitis or eczema 1.4 3.0 9.0 1.4 1.1 -1.5 1.9 -0.0 -3.0
Multivitamins +/- minerals 2.0 2.5 5.0 -1.6 -0.6 -0.3 -2.1 -2.2 1.7
Stomach or abdominal pain in last month 0.5 0.6 1.6 -0.0 0.1 -1.3 1.1 0.9 -0.3
Supplements: Glucosamine 1.3 1.7 4.5 1.2 1.4 2.1 1.1 0.9 -0.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.0 -0.7 -0.2 -0.1 -1.0 -0.3 0.9
Medication: Atenolol 0.3 0.4 0.9 0.5 1.0 -0.2 -0.7 -0.7 -0.3
Medication: Levothyroxine sodium 3.2 5.3 11.4 -2.3 -1.4 -0.4 -3.2 -3.4 1.9
Sitting height 0.7 4.7 10.8 -2.1 -2.5 -3.3 -1.1 -1.4 1.9
Chronic bronchitis/emphysema (father) 1.5 1.7 3.2 1.0 1.0 1.8 1.4 0.6 -1.8
High blood pressure (mother) 2.6 3.6 9.4 1.7 0.7 1.2 3.1 2.6 -0.7
Body mass index (BMI) 0.5 2.0 4.5 -1.0 -2.1 0.9 1.6 1.4 -1.1
Impedance of leg (left) 0.2 0.9 2.9 0.0 0.5 0.1 -0.8 -1.1 1.7
Leg predicted mass (left) 0.8 4.3 11.9 -3.1 -3.4 -1.7 -0.1 -0.8 0.7
Trunk fat mass 1.7 7.5 24.5 -4.3 -5.0 -0.9 -0.5 -0.8 0.6
Waist circumference 0.5 2.0 4.2 -1.2 -2.0 0.2 1.7 1.8 -0.6
Number of incorrect matches in round 0.6 1.0 3.5 1.3 1.9 -0.3 0.8 -0.3 -0.2
Past tobacco smoking 0.7 1.3 5.5 0.4 -0.2 -2.4 0.6 0.4 -1.2
Alcohol usually taken with meals 0.7 1.1 6.4 0.4 0.1 -2.5 0.5 0.2 -0.1
Nervous feelings 0.1 0.1 0.4 0.2 0.3 -0.2 0.2 -0.7 -0.2
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 5.0 1.5 0.6 0.6 2.2 1.4 -1.4
Hearing difficulty/problems with background noise 0.7 1.2 4.4 -0.1 -0.2 -1.1 -0.6 -1.1 -2.1
Hair/balding pattern: Pattern 2 1.0 1.2 3.3 -0.1 0.5 1.8 -1.3 0.3 1.4
Had menopause 0.5 0.7 3.1 -0.0 0.2 0.1 -0.6 -0.7 -1.8
Had other major operations 3.8 4.7 10.0 2.4 1.6 -0.5 3.2 1.7 -2.6
Forced vital capacity (FVC) 0.7 2.9 7.3 -0.9 0.2 -1.0 -2.0 -2.7 2.0
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.8 10.0 2.3 1.8 -0.1 3.2 1.3 -2.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.1 1.0 1.0 0.6 0.8 0.2 0.4
Qualifications: None of the above 2.8 6.1 10.4 2.9 2.9 3.2 2.3 1.6 -1.3
Financial difficulties in last 2 years 0.3 0.4 1.0 0.6 0.7 0.2 -0.6 1.0 0.7
Mouth/teeth dental problems 0.8 1.2 2.2 1.3 1.5 0.1 1.5 1.0 0.1
Heart attack 0.4 0.5 1.4 0.1 0.3 -1.2 0.2 0.7 -0.9
Allergy 2.1 4.8 10.3 -2.3 -1.8 1.5 -2.8 -0.0 3.2
Pain all over the body in last month 1.3 1.4 4.8 0.3 -0.6 2.2 0.4 0.5 -1.8
Diabetes (self-reported) 0.5 0.7 1.7 0.7 0.3 0.7 1.3 1.2 -0.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.5 1.2 1.0 0.2 0.3 -0.4 -0.8
Medication: Ramipril 1.3 1.6 4.7 0.9 0.0 -1.0 2.2 1.7 -0.6
Medication: Simvastatin 1.5 2.2 4.3 2.1 1.5 1.1 1.7 1.6 -0.5
Fluid intelligence score 0.8 1.7 2.9 -1.2 -1.0 -0.3 -1.7 -1.4 1.7
Illnesses of siblings 1.1 1.5 3.0 -1.4 -0.6 -0.4 -1.4 -1.7 1.3
Neuroticism score 0.7 1.5 2.7 1.4 1.1 0.5 1.7 1.0 -1.4
Weight 0.9 4.4 14.8 -3.2 -3.9 -1.0 0.4 -0.2 0.3
Impedance of arm (right) 2.5 11.4 23.3 -3.9 -2.3 -1.9 -4.8 -4.0 2.3
Arm fat percentage (right) 0.8 3.1 11.2 -2.6 -3.3 0.1 0.1 0.2 -0.6
Trunk fat-free mass 0.3 1.4 2.8 -1.0 -1.7 -1.6 1.4 0.4 0.2
Hip circumference 0.6 2.5 7.2 -2.2 -2.7 -1.3 -0.5 -0.8 0.4
Time employed in main current job 0.6 0.7 1.4 -0.8 -1.1 -0.6 -0.3 1.2 0.7
Alcohol intake versus 10 years previously 4.1 6.1 19.0 1.6 1.2 4.4 2.4 2.8 -0.5
Father’s age at death 0.6 0.8 3.3 0.3 -0.1 -1.8 1.1 0.4 -0.3
Worrier / anxious feelings 0.9 1.7 3.1 1.4 1.2 0.0 1.8 1.4 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.8 0.6 0.6 0.0 1.4 0.7 -1.7
Falls in the last year 0.6 0.9 1.9 -1.3 -1.4 -0.9 -0.1 -0.6 0.8
Hair/balding pattern: Pattern 3 0.3 0.5 1.1 1.1 1.0 -0.3 -0.1 0.1 -0.9
Number of live births 0.8 1.2 2.3 1.4 1.5 1.0 1.0 0.9 -0.2
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 7.9 0.1 1.4 -0.6 -2.0 -2.8 1.7
Pulse rate 1.2 2.0 5.1 -1.5 -2.0 2.3 0.2 -0.6 0.1
Happiness 2.1 2.5 6.3 -2.5 -1.8 -0.7 -1.4 -1.6 0.7
Noisy workplace 0.8 1.0 3.7 -0.6 -1.1 0.3 0.3 -0.6 -1.9
Qualifications: A levels/AS levels or equivalent 1.3 3.0 6.1 -1.4 -1.3 -1.0 -2.5 -2.4 1.2
Serious illness, injury or assault of a close relative in last 2 years 1.7 2.0 5.9 1.6 0.7 -0.2 2.4 1.6 -0.6
Mouth/teeth dental problems: Dentures 0.5 0.9 1.9 0.9 0.4 1.2 0.5 1.4 -0.9
Asthma 1.5 3.0 6.7 2.1 1.2 -0.4 2.3 0.3 -2.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.0 -1.0 -1.4 -0.3 0.1 -0.1 -0.0
Medication: Cholesterol lowering 1.0 1.5 4.7 0.8 -0.1 -0.3 1.4 2.2 -1.4
Depression (self-reported) 1.4 1.7 3.4 1.7 1.8 -0.6 0.9 -0.9 -1.3
Medication: Lansoprazole 0.6 0.6 3.5 0.2 0.2 -1.9 -0.1 -0.3 -0.3
Prospective memory result 2.1 2.6 4.4 1.7 1.8 1.4 -0.3 -1.8 -2.1
Lung cancer (father) 0.1 0.1 0.2 0.2 -0.2 0.3 0.2 0.4 0.2
Illnesses of mother 0.6 0.8 1.5 0.6 0.8 -1.2 -0.9 -0.3 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 7.1 -1.0 0.4 -0.4 -2.5 -2.7 2.4
Pulse wave Arterial Stiffness index 2.1 2.5 5.2 1.9 1.6 2.3 1.6 0.9 -0.2
Impedance of arm (left) 3.0 13.8 24.7 -4.7 -3.1 -2.2 -5.0 -4.0 2.5
Arm fat mass (right) 0.8 3.4 12.2 -2.7 -3.5 -0.3 0.8 0.4 -0.4
Trunk predicted mass 0.3 1.4 2.9 -1.0 -1.7 -1.6 1.4 0.4 0.2
Standing height 1.4 13.9 22.8 -4.8 -3.9 -4.3 -2.5 -3.2 3.1
Length of working week for main job 0.6 0.6 2.4 -0.1 -0.3 1.0 -0.3 0.5 -1.6
Exposure to tobacco smoke at home 0.4 0.4 1.3 -0.0 -0.8 0.6 0.5 0.3 -1.1
Breastfed as a baby 0.1 0.1 0.2 0.1 0.2 -0.4 0.1 -0.2 -0.4
Tense / ‘highly strung’ 1.2 2.0 5.1 1.9 1.3 0.5 1.3 0.2 -2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.3 0.3 -0.1 -0.2 0.9 0.6 -1.1
Hair/balding pattern: Pattern 4 1.7 4.0 10.5 3.2 2.5 1.1 1.9 1.6 -0.2
Birth weight of first child 0.6 1.1 3.0 -1.5 -1.7 -0.7 0.6 -0.7 -0.0
Peak expiratory flow (PEF) 1.3 2.9 6.0 -1.6 -0.4 -0.4 -2.4 -2.4 1.7
Pulse wave reflection index 1.6 1.9 3.8 1.9 1.8 -0.2 1.4 1.5 -0.6
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 0.1 -0.1 0.3 -0.1 0.2 -0.2
Loud music exposure frequency 2.3 2.6 4.1 -2.0 -2.0 -1.5 -1.3 -1.8 -0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.7 0.5 0.1 -1.6 0.4 0.3 0.8
Mouth/teeth dental problems: Bleeding gums 2.1 2.8 5.8 -1.0 -1.2 -2.4 -1.3 -2.4 -1.1
Blood clot in the leg (DVT) 2.8 3.6 6.9 2.5 2.6 1.1 1.8 0.7 -1.8
Medication: Paracetamol 0.5 0.8 2.5 -0.2 -0.8 1.6 0.5 0.8 0.8
Headache pain in last month 0.0 0.1 0.2 0.0 -0.1 -0.2 0.4 -0.2 -0.5
Medication for cholesterol, blood pressure or diabetes 2.6 4.3 9.7 -2.0 -0.7 -0.4 -3.1 -2.7 2.0
Glaucoma (self-reported) 0.3 0.3 0.6 0.6 0.4 -0.7 -0.6 0.3 0.8
Gout (self-reported) 0.8 1.1 3.3 1.0 0.6 0.1 1.3 0.4 -1.8
Hypothyroidism/myxoedema (self-reported) 2.7 5.3 10.2 -2.7 -1.4 -0.3 -3.2 -2.5 2.4
Medication: Amlodipine 3.9 5.5 9.8 2.4 1.5 2.0 3.1 2.8 -1.7
Medication: Ventolin 100micrograms inhaler 1.9 2.4 5.4 1.9 0.7 0.9 2.0 0.5 -2.3
Birth weight 0.6 1.3 6.3 -0.2 0.4 2.5 0.5 0.7 0.9
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.1 -0.6 -0.7 -0.8 0.0 -1.0 -0.4
High blood pressure (siblings) 1.7 2.5 4.3 2.1 1.8 1.4 1.5 1.3 -1.4
Forced vital capacity (FVC), Best measure 1.3 4.6 7.9 -2.2 -1.0 -0.6 -2.5 -2.7 2.8
Body fat percentage 1.4 5.4 18.6 -3.6 -4.3 -0.1 -0.4 -0.6 0.3
Leg fat percentage (right) 0.5 1.8 4.4 -1.1 -2.1 1.4 1.2 1.1 -0.7
Arm fat-free mass (right) 0.4 2.2 5.1 -1.1 -2.1 -1.2 2.3 1.0 0.1
Exposure to tobacco smoke outside home 1.0 1.3 3.1 0.7 0.4 1.1 1.8 1.3 -1.1
Comparative body size at age 10 0.3 0.9 3.6 0.6 -0.7 0.5 0.8 0.5 -1.9
Number of full brothers 1.2 1.5 2.2 1.4 0.8 0.8 1.4 1.5 -1.2
Worry too long after embarrassment 0.6 1.0 3.2 -0.8 0.1 0.0 -1.8 -1.1 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.9 -1.3 -1.7 -1.1 -0.8 0.4 0.3
Wheeze or whistling in the chest in last year 0.9 1.6 4.8 0.6 0.4 -2.2 0.5 -1.3 -1.5
Number of children fathered 1.0 1.2 2.3 -0.1 -1.0 -0.7 1.3 1.3 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.3 -0.8 -1.0 0.5 -0.3 1.2 1.0
Age at first live birth 6.2 11.0 17.5 -4.2 -2.8 -2.3 -3.2 -3.1 4.0
Pulse wave peak to peak time 2.8 3.2 6.3 -2.3 -2.0 -2.5 -1.7 -0.9 0.5
Health satisfaction 1.2 1.6 5.2 -0.2 -0.8 0.4 1.9 2.3 0.2
Shortness of breath walking on level ground 2.2 2.7 5.1 2.1 1.9 0.5 1.4 0.8 -2.3
Qualifications: College or University degree 4.6 14.5 22.6 -4.6 -3.6 -2.5 -4.8 -4.0 2.8
Eye problems/disorders: None of the above 0.5 0.6 1.6 -1.0 -1.3 0.1 0.1 0.1 1.1
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.7 -1.3 -1.2 0.5 -1.2 -0.4 0.0
Emphysema/chronic bronchitis 0.6 0.7 1.3 0.7 0.3 0.7 1.0 0.9 -1.1
Medication for pain relief, constipation, heartburn 0.3 0.6 1.6 0.7 1.3 -0.3 -0.3 -0.9 -0.7
Neck or shoulder pain in last month 0.5 0.8 2.2 -0.3 -0.9 -1.5 0.6 -0.3 -1.0
Medication: Blood pressure 3.5 6.1 13.0 2.6 1.0 0.7 3.6 3.1 -2.4
Angina (self-reported) 3.6 4.7 11.7 3.0 3.4 0.1 1.3 2.2 -1.0
Migraine (self-reported) 1.2 1.5 6.9 0.2 0.8 2.6 0.2 0.7 1.0
Medication: Ibuprofen 0.5 0.6 1.7 -1.1 -1.3 -0.3 -0.5 -0.5 0.2
Medication: Allopurinol 0.9 1.2 2.2 1.5 1.2 0.2 1.3 0.8 -1.0
Medication: Omeprazole 0.4 0.5 1.3 -1.2 -0.8 0.8 -0.4 -0.1 0.5
Medication: Seretide 50 evohaler 1.5 1.8 4.2 1.6 0.7 0.2 2.0 1.6 -0.8
Mean time to correctly identify matches 0.6 1.2 2.5 0.8 0.9 1.2 -0.7 -1.0 -1.6
Heart disease (mother) 0.6 0.7 2.7 0.1 -0.3 0.8 1.6 1.0 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.0 1.0 0.7 -0.3 0.8 0.2 -0.3
Whole body fat mass 1.2 5.2 18.2 -3.6 -4.3 -0.4 0.2 -0.1 0.3
Leg fat mass (right) 0.6 2.4 8.0 -1.9 -2.8 0.6 1.3 0.8 -0.2
Arm predicted mass (right) 0.4 1.9 4.8 -0.9 -1.8 -1.0 2.2 1.1 0.2
Pulse rate, automated reading 0.9 2.8 8.1 -2.4 -2.8 0.7 -0.3 0.4 1.4
Alcohol intake frequency. 0.4 1.0 3.6 0.3 -0.0 1.9 0.9 0.1 -1.2
Comparative height size at age 10 2.1 11.5 20.8 -4.6 -3.9 -2.6 -3.1 -3.4 2.0
Number of full sisters 0.3 0.4 1.9 0.0 -0.0 -0.5 -0.1 -0.5 1.4
Suffer from ‘nerves’ 1.6 2.5 5.5 2.2 1.8 0.5 0.9 -0.6 -2.3
Overall health rating 0.7 1.6 4.7 -0.7 -1.2 0.4 2.2 1.6 0.1
Chest pain or discomfort 1.2 1.8 4.6 1.8 2.1 0.7 0.1 0.2 -1.5
Had major operations 0.5 0.6 2.9 -0.1 0.2 -1.7 0.4 -0.5 -0.1
Age at last live birth 4.9 7.2 14.0 -3.3 -2.4 -1.2 -2.2 -2.5 3.7
Family relationship satisfaction 0.4 0.4 1.2 -0.6 -0.7 -1.1 -0.1 -0.6 0.5
Leg pain on walking 0.7 0.9 3.7 0.0 0.4 0.7 0.5 1.9 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.4 -0.6 -0.3 0.1 0.2 0.4
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.1 0.8 0.5 1.4 0.4 0.5 -0.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.5 -0.2 0.1 -0.2 -1.0 -1.2 -0.0
Medication: Aspirin 0.3 0.4 0.8 0.3 0.6 0.9 -0.1 0.8 0.6
Supplements: Vitamin C 3.1 3.7 8.1 -1.4 -0.6 -1.6 -2.6 -2.8 1.5
Knee pain experienced in last month 1.5 2.3 4.7 1.8 1.2 0.4 2.0 2.2 0.5
Hypertension (Self-reported) 2.1 5.8 11.8 3.0 2.0 0.4 3.4 2.8 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.5 0.1 0.0 -0.2 -0.7 -0.3 0.3
Illnesses of father: Heart disease 0.2 0.3 1.2 -0.3 -0.6 0.3 0.3 1.1 0.2
Illnesses of siblings: Diabetes 1.2 1.5 4.0 0.9 1.1 1.7 0.2 2.0 -0.1
Smoking status: Previous 0.6 0.9 2.0 -0.9 -0.4 1.2 -0.8 -0.3 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.1 0.4 0.7 -0.6 1.0 0.9 0.2
Whole body fat-free mass 0.4 2.3 5.9 -1.8 -2.4 -1.8 1.1 0.2 0.4
Leg fat-free mass (right) 0.9 4.8 13.1 -3.3 -3.6 -1.9 -0.0 -0.6 1.0
Arm fat percentage (left) 1.0 4.1 14.5 -3.1 -3.8 -0.0 -0.1 0.0 -0.6
Average weekly red wine intake 2.2 3.2 6.5 -1.6 -0.6 -2.3 -2.5 -1.9 1.0
Handedness (chirality/laterality): Left-handed 2.2 2.7 7.6 2.6 2.8 0.3 1.0 0.3 -0.7
Mood swings 0.5 1.0 3.3 0.3 -0.2 0.1 1.4 0.5 -1.8
Loneliness, isolation 0.4 0.5 1.6 -0.8 -1.3 0.1 0.6 0.5 -0.6
Long-standing illness, disability or infirmity 0.7 1.1 3.2 -1.3 -1.8 -0.7 0.2 0.7 0.8
Ever had bowel cancer screening 1.0 1.1 2.7 -1.0 -1.1 -1.2 -0.5 -0.6 -1.7
Diabetes diagnosed by doctor 0.9 1.5 3.8 1.1 0.5 0.8 1.7 1.9 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.1 1.0 1.0 0.7 0.7 -0.1 -0.5
Friendships satisfaction 0.6 0.8 1.7 -1.2 -1.3 -0.8 -0.6 -0.2 0.6
Qualifications: nursing, teaching 1.8 2.8 5.7 -1.8 -2.4 -1.6 -1.7 -1.4 -0.8
Commuting to job workplace: Walk 1.3 1.4 3.6 -1.2 -1.1 -1.1 -0.7 -0.6 1.9
Eye problems/disorders: Cataract 0.2 0.2 1.0 0.1 0.4 0.2 -1.0 -0.4 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.0 -1.4 -1.0 -0.9 -0.8 -0.4 1.4
Medication for cholesterol 0.9 1.3 3.6 -0.6 -0.7 0.5 -0.8 -1.9 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.7 -0.3 -0.1 -0.3 -0.9 -1.1 1.3
Back pain experienced in last month 1.2 1.7 3.7 1.7 1.2 -0.1 1.9 1.1 -1.1
Mineral and other dietary supplements 0.4 0.6 1.2 0.9 0.2 0.1 0.8 1.1 -0.9
Breast cancer (self-reported) 0.6 0.8 1.7 -1.3 -1.1 -1.3 -0.1 -0.1 -0.1
Asthma (self-reported) 1.5 3.0 6.3 2.3 1.5 0.0 2.1 0.0 -2.5
Osteoporosis (self-reported) 1.3 1.6 4.0 -1.5 -0.8 -0.7 -2.0 -0.6 1.4
Osteoarthritis (self-reported) 1.5 2.0 8.3 0.9 0.7 2.9 0.6 1.3 0.2
Medication: Aspirin 0.2 0.3 0.7 0.0 0.2 0.8 -0.2 0.8 0.5
Medication: Gliclazide 0.8 0.9 3.1 0.5 0.3 -1.2 1.8 0.2 -0.4
Illnesses of father: None of the above (group 1) 0.3 0.3 0.9 -1.0 -0.8 -0.2 -0.2 -0.1 0.6
Smoking status: Current 0.3 0.5 1.7 0.7 0.9 1.3 -0.2 0.2 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 6.1 -0.2 0.9 -0.0 -2.5 -1.8 1.0
Whole body water mass 0.4 2.2 5.9 -1.8 -2.4 -1.7 1.2 0.2 0.4
Leg predicted mass (right) 0.9 5.0 13.6 -3.3 -3.7 -1.9 -0.1 -0.6 1.1
Arm fat mass (left) 0.9 3.7 13.4 -2.9 -3.7 -0.2 0.6 0.3 -0.3
Number of self-reported non-cancer illnesses 0.3 0.6 1.7 0.2 -0.3 -1.3 0.9 0.8 -0.5
Average weekly champagne plus white wine intake 0.3 0.4 1.2 0.6 0.6 -1.1 0.3 0.5 0.0
Miserableness 1.5 2.7 6.2 0.6 -0.6 1.1 2.3 1.6 -2.5
Guilty feelings 2.0 3.0 7.1 2.0 2.2 2.7 0.3 1.3 -0.3
Wears glasses or contact lenses 2.4 2.8 5.4 -1.4 -1.2 -1.7 -1.7 -2.3 1.3
Ever taken oral contraceptive pill 1.3 1.4 2.7 0.9 1.4 -1.4 -1.6 -1.1 0.3
Hearing aid user 0.6 0.7 2.5 0.3 -0.2 0.7 1.6 0.9 -0.6
Mother’s age at death 1.0 1.2 3.2 -1.3 -1.2 0.5 -0.8 0.5 1.8
Financial situation satisfaction 0.8 1.0 1.8 1.2 1.4 -0.0 1.1 0.7 -1.1
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.7 -0.4 -0.7 -0.2 1.3 -0.0 0.2
Commuting to job workplace: Public transport 0.9 1.1 3.3 -0.6 0.2 0.2 -1.6 -1.8 0.0
Eye problems/disorders: Glaucoma 0.2 0.3 0.7 0.9 0.5 -0.4 -0.6 0.1 -0.2
Medication: Blood pressure 0.7 1.4 3.6 1.1 1.0 -0.9 1.3 1.9 0.3
Pain type(s) experienced in last month: Hip pain 3.0 3.7 10.4 0.1 -1.4 -0.0 3.2 2.8 -1.5
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.2 -1.4 -1.1 0.7 -0.7 -1.5 -0.1
High cholesterol (Self-reported) 1.1 2.0 9.2 0.7 -0.3 -0.3 1.4 3.0 -0.4
Medication: Bendroflumethiazide 1.3 1.9 3.6 1.6 1.2 0.3 1.3 1.9 -1.4
Medication: Paracetamol 0.2 0.4 1.1 0.1 -0.6 1.0 0.2 0.7 0.3
Medication: Lisinopril 3.8 4.9 10.7 3.3 3.0 -0.4 1.9 1.2 -2.2
Medication: Atorvastatin 1.2 1.4 3.1 -0.8 -1.3 -1.7 0.4 1.8 -0.1
Illnesses of father: High blood pressure 0.6 0.8 1.7 0.6 0.5 -0.6 0.7 1.3 1.2
Alcohol drinker status: Never 0.3 0.4 1.5 0.3 0.6 -1.2 -0.3 -0.2 0.3
Ever smoked 0.8 1.4 5.4 -0.9 -0.2 2.3 -1.0 -0.7 1.0
Basal metabolic rate 0.5 3.0 8.9 -2.4 -3.0 -1.7 0.9 0.0 0.5
Leg fat percentage (left) 0.6 2.3 6.2 -1.3 -2.5 1.3 1.4 1.3 -0.5
Arm fat-free mass (left) 0.4 2.0 4.5 -1.2 -2.1 -1.0 1.9 1.1 0.4
Number of operations (self-reported) 1.0 1.5 3.6 1.2 0.9 -0.2 1.9 0.4 -1.7
Average weekly beer plus cider intake 0.5 0.7 3.3 0.3 0.4 1.8 0.6 0.6 0.2
Irritability 1.1 1.8 5.3 2.3 2.1 -1.0 0.1 -0.2 -0.5
Risk taking 0.4 0.6 2.2 0.3 -0.3 -0.5 0.1 1.5 -0.9
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.6 -1.3 -1.6 -0.7 -0.6 0.2 0.6
Fractured/broken bones in last 5 years 0.3 0.4 1.2 -0.6 -0.2 1.1 -0.5 0.1 0.8
Age started oral contraceptive pill 0.9 1.1 2.9 -0.9 -0.2 -0.4 -1.7 -1.4 -0.8
Diastolic blood pressure, automated reading 0.4 1.3 4.5 -0.3 -1.1 -0.7 0.6 -1.0 -2.1
Ever depressed for a whole week 0.6 0.7 1.7 1.3 1.3 0.1 0.4 0.7 -0.7
Unable to work because of sickness or disability 0.1 0.1 0.4 -0.1 0.3 0.7 0.0 0.0 -0.4
Commuting to job workplace: Cycle 0.7 0.8 1.7 -0.0 1.1 -0.4 -1.3 -0.2 1.3
Myopia 1.9 2.8 7.8 -1.9 -2.0 0.5 -0.9 -0.3 2.8
Vascular/heart problems diagnosed by doctor 1.8 4.9 8.3 -2.8 -2.0 -0.0 -2.8 -2.9 1.2
Cholesterol lowering medication 1.1 1.7 6.4 1.2 0.9 0.5 0.6 2.5 0.9
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.4 -0.2 -0.2 0.7 0.1 0.1 -0.1
Pain experienced in last month 2.2 3.7 8.2 -1.8 -1.0 -0.8 -2.9 -2.6 1.6
Supplements: Calcium 2.5 2.7 5.5 -1.8 -1.4 -0.8 -2.3 -2.2 -0.2
Basal cell carcinoma (self-reported) 1.0 1.1 3.3 -1.6 -1.8 -0.0 -0.2 -0.3 0.9
Heart attack/myocardial infarction (self-reported) 0.4 0.6 1.5 0.4 0.6 -1.2 -0.0 0.6 -0.9
Deep venous thrombosis (DVT) (self-reported) 2.2 2.9 5.5 2.2 2.3 1.2 1.6 0.7 -1.6
Heart disease (siblings) 0.3 0.3 0.8 0.3 -0.5 0.0 0.9 0.4 -0.8
Alcohol drinker status: Previous 0.5 0.6 2.9 0.4 0.3 1.7 0.4 -0.0 0.2
Pack years of smoking 0.1 0.2 0.5 0.7 0.2 0.5 -0.7 0.3 -0.1
Impedance of whole body 1.3 6.4 12.0 -2.8 -1.6 -1.1 -3.5 -3.0 2.4
Leg fat mass (left) 0.7 2.7 9.0 -2.0 -3.0 0.5 1.4 0.9 -0.1
Arm predicted mass (left) 0.3 1.6 4.1 -0.9 -1.9 -0.8 2.0 0.8 0.2