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chr11:29,646,947-36,251,046

Best TWAS P=2.57e-31 · Best GWAS P=2.08e-28 conditioned to 0.000441

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DCDC1	0.05	0.03	blup	453	0.02	1.9e-03	-5.3	-5.6	2.2e-08	-0.15	0.42	0.06	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DCDC5	0.06	0.03	enet	38	0.06	1.9e-07	-5.1	-5.6	1.9e-08	-0.23	0.98	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PAMR1	0.23	0.07	lasso	8	0.14	1.1e-16	-7.7	5.7	1.4e-08	0.08	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	ELP4	0.07	0.04	lasso	3	0.04	5.8e-04	-5.2	-5.2	1.5e-07	-0.03	0.39	0.55	FALSE
5	GTEx	Adipose Visceral Omentum	ELP4	0.10	0.12	enet	7	0.12	8.8e-07	-5.2	-5.4	6.4e-08	-0.02	0.41	0.56	FALSE
6	GTEx	Adrenal Gland	CD59	0.18	0.08	enet	15	0.08	7.3e-04	-4.8	-5.1	2.8e-07	-0.03	0.02	0.96	FALSE
7	GTEx	Artery Aorta	RCN1	0.19	0.17	enet	13	0.15	1.9e-08	-4.9	5.5	4.0e-08	-0.02	0.73	0.26	FALSE
8	GTEx	Artery Aorta	CD59	0.12	0.10	lasso	3	0.10	2.2e-06	-5.1	-5.4	6.5e-08	-0.01	0.01	0.99	FALSE
9	GTEx	Artery Tibial	CD59	0.26	0.10	enet	16	0.20	2.6e-15	-5.1	-5.4	5.2e-08	-0.01	0.01	0.99	FALSE
10	GTEx	Brain Cerebellum	HNRNPA3P9	0.20	0.03	enet	20	0.07	4.9e-03	-5.3	-5.5	2.8e-08	0.00	0.02	0.82	TRUE
11	GTEx	Breast Mammary Tissue	ELP4	0.09	0.04	lasso	5	0.05	1.8e-03	-5.1	-6.0	2.3e-09	-0.12	0.03	0.82	FALSE
12	GTEx	Breast Mammary Tissue (Female)	ELP4	0.26	0.12	lasso	5	0.07	5.2e-03	6.3	-6.6	5.1e-11	-0.06	0.01	0.93	TRUE
13	GTEx	Cells EBV-transformed lymphocytes	ARL14EP	0.38	0.31	enet	34	0.32	4.1e-11	-9.9	7.9	2.6e-15	0.31	0.97	0.02	FALSE
14	GTEx	Cells Transformed fibroblasts	CD59	0.12	0.06	lasso	6	0.08	1.9e-06	-4.8	-5.5	4.4e-08	0.01	0.06	0.92	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	CD59	0.25	0.16	lasso	9	0.15	4.2e-06	-4.7	-5.6	2.2e-08	0.00	0.02	0.97	FALSE
16	GTEx	Esophagus Muscularis	CD59	0.30	0.24	lasso	7	0.31	2.4e-19	4.4	-5.5	4.8e-08	0.02	0.09	0.89	FALSE
17	GTEx	Heart Left Ventricle	MPPED2	0.13	0.01	lasso	5	-0.01	8.1e-01	6.0	8.0	1.2e-15	0.46	0.13	0.07	TRUE
18	GTEx	Heart Left Ventricle	HNRNPA3P9	0.09	0.08	lasso	2	0.05	8.2e-04	-5.3	-5.3	1.4e-07	-0.01	0.02	0.96	FALSE
19	GTEx	Lung	CD59	0.19	0.10	lasso	6	0.08	6.4e-07	-5.1	-5.3	1.4e-07	-0.02	0.01	0.99	FALSE
20	GTEx	Muscle Skeletal	CD59	0.09	0.02	lasso	5	0.01	1.7e-02	4.9	-5.7	1.2e-08	0.03	0.02	0.92	FALSE
21	GTEx	Nerve Tibial	CD59	0.18	0.10	lasso	7	0.10	1.2e-07	-5.1	-5.8	8.6e-09	-0.01	0.01	0.98	TRUE
22	GTEx	Pancreas	PDHX	0.28	0.06	lasso	17	0.07	8.4e-04	3.9	5.2	1.6e-07	-0.05	0.64	0.04	TRUE
23	GTEx	Skin Not Sun Exposed Suprapubic	RCN1	0.18	0.07	lasso	5	0.08	2.8e-05	-3.7	5.2	2.3e-07	-0.02	0.35	0.10	FALSE
24	GTEx	Spleen	ARL14EP	0.34	0.19	enet	24	0.30	1.7e-08	-9.9	9.0	2.5e-19	0.27	0.53	0.04	FALSE
25	GTEx	Testis	CD59	0.32	0.12	lasso	9	0.15	4.0e-07	4.9	-5.3	1.1e-07	0.03	0.07	0.92	FALSE
26	GTEx	Testis	DEPDC7	0.14	0.10	enet	35	0.07	4.0e-04	-2.8	-5.5	3.6e-08	-0.01	0.55	0.05	FALSE
27	GTEx	Testis	ARL14EP	0.43	0.36	lasso	3	0.37	1.8e-17	7.0	7.6	2.9e-14	0.26	1.00	0.00	FALSE
28	GTEx	Thyroid	RCN1	0.16	0.09	enet	23	0.11	6.9e-09	-4.9	5.2	2.0e-07	-0.04	0.82	0.17	TRUE
29	GTEx	Thyroid	MPPED2	0.16	0.01	enet	13	0.07	2.3e-06	9.4	-7.1	1.6e-12	-0.66	0.23	0.68	FALSE
30	GTEx	Thyroid	ARL14EP	0.20	0.05	lasso	6	0.09	1.0e-07	7.0	5.2	1.5e-07	0.10	0.99	0.00	FALSE
31	GTEx	Whole Blood	ARL14EP	0.07	0.05	lasso	2	0.05	3.3e-05	-9.9	10.1	9.0e-24	0.42	0.80	0.04	FALSE
32	METSIM	Adipose	CD59	0.08	0.05	lasso	10	0.07	7.6e-11	-5.1	-5.3	1.1e-07	0.00	0.01	0.99	FALSE
33	NTR	Blood	CD59	0.05	0.04	lasso	5	0.04	1.7e-13	-5.1	-5.5	3.2e-08	-0.02	0.01	0.99	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	MPPED2	0.25	0.29	lasso	7	0.29	4.4e-37	6.5	-6.1	8.2e-10	-0.50	1.00	0.00	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	CD59	0.17	0.11	lasso	9	0.12	8.6e-16	4.4	-5.5	4.7e-08	0.02	0.08	0.89	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	PAMR1	0.09	0.05	lasso	3	0.05	1.5e-06	-7.7	7.4	1.5e-13	0.05	0.00	1.00	TRUE
37	YFS	Blood	CSTF3	0.13	0.02	bslmm	338	0.08	1.3e-23	5.3	6.4	1.6e-10	0.00	0.02	0.97	TRUE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DNAJC24	0.05	0.01	blup	31	0.01	9.4e-02	-5.3	-5.2	1.6e-07	-0.04	0.02	0.14	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf46	0.05	0.05	lasso	5	0.06	6.2e-12	-10.2	10.6	2.2e-26	0.43	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	IMMP1L	0.11	0.02	blup	40	0.03	1.0e-02	-3.2	-5.2	2.3e-07	-0.02	0.02	0.56	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	C11orf46	0.12	0.08	blup	34	0.07	5.7e-05	9.6	10.9	8.7e-28	0.61	0.02	0.85	FALSE
42	The Cancer Genome Atlas	Esophageal Carcinoma	C11orf46	0.17	0.07	blup	34	0.11	2.5e-04	-3.4	5.4	6.5e-08	0.25	0.01	0.85	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C11orf46	0.06	0.06	lasso	2	0.05	5.5e-06	-9.9	9.6	6.5e-22	0.41	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DNAJC24	0.05	0.02	lasso	3	0.02	6.7e-03	-5.2	-5.3	1.5e-07	-0.03	0.09	0.29	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IMMP1L	0.04	0.02	lasso	1	0.01	1.1e-02	-5.2	-5.2	1.5e-07	-0.03	0.02	0.11	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C11orf46	0.36	0.27	lasso	5	0.30	8.3e-34	-9.9	10.8	2.7e-27	0.48	0.03	0.97	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C11orf46	0.13	0.12	lasso	3	0.11	8.9e-07	-9.9	9.9	5.1e-23	0.42	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf46	0.02	0.02	lasso	2	0.02	5.9e-03	7.6	7.6	2.8e-14	0.30	0.02	0.13	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	CD59	0.05	0.05	lasso	3	0.05	1.5e-06	4.9	-5.6	2.5e-08	0.03	0.03	0.93	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C11orf46	0.12	0.07	blup	34	0.07	4.4e-04	-9.9	11.6	2.6e-31	0.55	0.01	0.88	TRUE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	C11orf46	0.09	0.11	lasso	4	0.10	1.2e-11	-9.9	10.6	3.9e-26	0.46	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC24	0.03	0.02	blup	31	0.01	3.8e-02	-5.3	-5.6	1.9e-08	-0.03	0.04	0.20	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf46	0.05	0.02	lasso	2	0.02	9.9e-04	4.3	7.8	5.4e-15	0.47	0.01	0.76	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C11orf46	0.07	0.04	blup	34	0.07	2.5e-05	4.3	7.5	7.1e-14	0.49	0.03	0.92	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C11orf46	0.22	0.22	lasso	3	0.20	1.1e-08	-9.9	10.0	2.0e-23	0.41	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf46	0.09	0.07	lasso	2	0.06	2.4e-07	-9.9	9.9	6.3e-23	0.41	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	IMMP1L	0.05	0.01	blup	40	0.00	1.8e-01	5.6	-6.0	1.5e-09	-0.02	0.00	0.71	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	C11orf46	0.11	0.05	enet	7	0.09	3.4e-07	-10.2	9.1	9.8e-20	0.48	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C11orf46	0.24	0.07	enet	6	0.14	1.1e-05	-10.2	6.6	4.4e-11	0.32	0.00	0.91	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf46	0.12	0.06	blup	34	0.10	1.4e-09	-9.9	10.3	4.9e-25	0.38	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	MPPED2	0.20	-0.01	blup	147	0.05	2.0e-02	5.0	9.2	2.6e-20	0.67	0.03	0.18	FALSE