Hub : Genes

DEPDC7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0500	0.0240	5.9e-03	0.012	0.026	0.001	0.026	0.014	1.3e-02	0.00033	2.2e-01	0.00038	6.1e-03
2	GTEx	Muscle Skeletal	0.0906	0.0328	8.0e-04	0.033	NA	0.052	NA	0.063	3.3e-04	NA	7.0e-06	NA	7.7e-07
3	GTEx	Nerve Tibial	0.2638	0.0510	5.3e-15	0.242	NA	0.234	NA	0.236	3.8e-17	NA	1.5e-16	NA	9.7e-17
4	GTEx	Prostate	0.1990	0.0780	2.3e-03	0.071	NA	0.124	NA	0.161	7.7e-03	NA	5.2e-04	NA	7.6e-05
5	GTEx	Testis	0.1390	0.0530	2.4e-04	0.102	NA	0.072	NA	0.070	2.9e-05	NA	4.0e-04	NA	5.0e-04
6	TCGA	Thyroid Carcinoma	0.0320	0.0220	3.9e-03	0.022	0.013	0.002	NA	0.009	3.1e-03	0.01700	1.9e-01	NA	4.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.2	1.9	5.3	-0.8	-2.3	-1.5	-0.6	1.4	-0.9
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	-0.7	-0.9	-0.2	0.9	-0.2	0.5
Depressed Affect (Nagel 2018)	0.3	0.7	2.8	-1.7	-0.4	-0.7	-0.0	0.3	-0.7
Depression (Nagel 2018)	0.7	1.0	1.8	-0.8	1.2	-1.0	-0.9	1.3	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.2	0.4	0.3	1.1	1.4	-0.0	1.8
Neuroticism (Nagel 2018)	0.1	0.3	1.3	-0.5	-1.1	0.3	0.6	-0.1	-0.0
Schizophrenia (2018)	0.6	1.3	2.7	-0.3	0.7	0.9	1.6	-1.2	1.4
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	0.9	0.6	0.7	0.4	-0.7	0.5
Worry (Nagel 2018)	0.1	0.3	0.6	-0.8	-0.2	0.7	0.1	-0.8	0.4
Alzheimer’s Disease (in mother)	3.6	4.3	8.5	2.9	2.6	1.7	2.2	-0.8	1.4
Alzheimer’s Disease (in father)	0.3	0.3	1.4	1.2	-0.1	0.4	-0.2	-0.5	0.2
Alzheimer’s Disease (including proxy)	1.7	2.5	6.5	2.5	2.2	0.8	1.6	-0.4	0.7
Crohns Disease (2017)	0.5	1.1	2.0	-0.6	1.4	-0.8	-1.3	1.0	-1.0
Irritable Bowel Disease (IBD)	0.6	1.5	3.0	-0.5	1.7	-0.9	-1.3	1.6	-0.6
Ulcerative Colitis (UC)	0.6	1.0	2.3	-0.1	1.5	-0.8	-1.3	1.3	-0.2
Major Depression (MDD)	0.5	0.6	1.5	-0.4	-1.2	0.6	0.4	0.5	1.0
Reaction Time	5.2	9.8	15.0	-1.6	0.4	-3.8	-3.9	3.5	-3.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	-0.7	-0.4	0.1	1.1	0.7	0.5
Breast Cancer	0.6	1.3	3.0	1.7	-0.3	1.7	0.0	-1.4	0.4
Ovarian Cancer	1.1	1.4	3.7	-1.3	1.9	0.9	-0.0	-1.1	1.1
Prostate Cancer	1.1	1.5	3.3	-1.4	0.6	1.0	1.1	-1.1	1.8
Age at First Birth	0.4	0.6	2.3	-0.4	0.1	0.5	1.5	-0.9	0.3
Bipolar Disorder (2011)	0.8	0.8	1.3	-1.1	-0.9	-0.9	0.7	1.1	-0.1
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.4	-0.1	0.2	-0.1	-0.8	0.7
Coronary Artery Disease (CAD)	1.0	1.1	3.6	-0.8	-0.1	-1.4	-0.2	0.8	-1.9
Crohns Disease (2012)	0.7	1.1	3.6	-0.7	1.9	-0.6	-0.5	1.1	-0.9
Mean Putamen Volume	2.1	2.4	3.8	-0.8	-0.3	1.8	1.7	-1.9	2.0
Fasting Glucose	0.3	0.4	1.0	-0.5	1.0	-0.8	0.4	0.0	-0.5
HbA1C	1.0	1.2	3.3	0.7	1.8	0.4	0.6	-0.5	1.5
HDL Cholesterol	0.8	1.4	3.2	0.1	-1.2	1.4	1.8	-0.3	1.3
LDL Cholesterol	0.1	0.2	0.4	0.6	-0.1	-0.0	-0.6	-0.1	-0.4
Lupus	2.1	3.3	4.8	0.1	-1.8	-1.9	-1.7	2.2	-2.2
Neuroticism (2016)	1.5	2.2	4.6	0.7	-2.1	2.1	1.0	-0.6	1.5
Primary Biliary Cirrhosis	0.4	0.5	1.6	0.6	-0.2	-0.2	1.0	1.3	0.3
Rheumatoid Arthritis	2.1	2.9	5.2	-0.7	2.3	-1.7	-2.2	0.1	-2.0
Schizophrenia (2014)	0.2	0.5	1.1	-0.5	1.1	0.4	0.8	-0.2	0.8
Triglycerides	0.4	0.6	2.7	0.7	-0.6	0.3	-1.6	-0.3	-0.2
Type 2 Diabetes (T2D) (2012)	4.1	4.7	9.9	-1.5	0.0	-3.1	-2.7	2.0	-2.1
Ulcerative Colitis	1.0	1.5	4.0	0.3	0.7	-1.4	-1.0	2.0	-1.1
Blood Eosinophil Count	0.3	2.3	8.9	-3.0	-1.2	-1.6	0.2	0.8	0.4
Blood Platelet Count	0.7	7.9	18.1	-0.6	2.9	1.9	4.2	-1.0	4.0
Blood Red Count	0.4	3.8	7.5	1.4	-0.9	2.4	2.6	-0.5	2.7
Blood White Count	0.7	5.1	9.5	-1.7	0.8	-2.8	-3.1	1.9	-2.5
Heel T-Score	0.9	7.1	23.6	0.1	4.9	-2.3	-0.9	2.9	-2.1
BMI	0.5	3.1	5.6	-0.9	-1.3	-2.4	-2.0	1.6	-2.0
Height	0.4	8.6	30.4	-1.1	-0.1	3.3	2.3	-5.5	1.9
Waist Hip Ratio (WHR)	0.4	1.6	3.1	-1.4	1.2	-1.8	-1.3	1.1	-0.5
Systolic Blood Pressure	0.2	0.8	1.5	-1.2	-0.7	-1.2	1.1	-0.3	-0.4
Smoking Status	0.2	0.5	1.3	-0.1	-0.8	0.6	-0.4	-1.1	0.8
Allergy or Eczema	0.2	0.6	2.5	-0.7	1.6	0.1	-0.6	0.6	0.3
Cardiovascular Disease	0.5	1.5	4.0	0.3	-0.9	-1.8	-0.6	0.8	-2.0
Hypothyroidism (self reported)	0.7	1.5	3.3	-0.6	-0.5	-1.5	-1.8	0.7	-1.6
Respiratory disease	0.6	1.3	2.9	-1.6	1.7	-0.7	-1.0	0.7	0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.4	-0.3	-0.5	-1.7	-0.9	1.9	-0.9
Lung FEV1/FVC ratio	0.4	1.9	6.0	2.5	-0.6	0.6	2.1	0.4	0.3
Lung FVC	1.9	9.6	20.8	3.2	-1.5	4.6	3.3	-0.7	3.6
Neuroticism	0.1	0.3	0.5	-0.7	-0.5	0.7	0.6	-0.3	0.1
Chronotype (morning person)	1.8	4.2	8.2	0.3	0.0	-2.9	-2.0	2.5	-2.5
Hair Pigment	0.1	2.3	7.6	-2.0	1.1	0.0	-0.9	-2.8	0.4
Tanning	0.1	1.1	3.6	0.0	1.9	-0.6	1.3	0.9	-0.0
Hand grip strength (left)	0.6	1.7	3.2	1.1	1.6	1.8	1.1	-1.0	1.0
Number of treatments/medications taken	0.7	1.2	1.6	-0.9	1.2	-1.1	-1.2	1.1	-1.0
Average weekly spirits intake	1.5	1.9	5.7	0.1	0.2	-1.1	-1.9	2.4	-0.9
Sensitivity / hurt feelings	1.1	1.9	3.9	1.1	-2.0	1.4	1.7	0.4	1.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.7	0.2	-0.6	-0.3	0.7	-0.8
Hearing difficulty/problems: Yes	0.1	0.2	1.0	0.3	-1.0	0.2	0.1	-0.3	-0.3
Relative age of first facial hair	1.9	3.9	9.3	0.3	1.4	-3.0	-0.8	1.9	-2.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.3	0.5	-0.0	1.5	0.5	0.0	1.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.3	-0.7	-1.5	0.9	-0.2	-1.0	0.3
Ever had hysterectomy (womb removed)	2.0	2.2	4.0	1.6	-1.1	2.0	0.6	-1.8	1.4
Systolic blood pressure, automated reading	0.1	0.4	1.1	-0.2	-0.7	-0.1	1.1	-0.6	0.4
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	7.5	0.2	0.7	-1.7	-2.0	2.7	-1.9
Angina	0.5	0.7	2.4	0.2	0.8	-0.7	0.5	1.6	-0.5
Medication for hormone replacement therapy	0.4	0.5	2.0	-0.1	-1.4	-0.4	-0.7	0.3	-0.1
Vitamin and mineral supplements	2.3	3.1	6.6	1.5	-0.4	2.0	2.6	-1.2	2.1
Supplements: Zinc	1.0	1.1	3.4	-1.3	-1.8	-0.5	0.5	0.3	-0.9
Medication: Co-codamol	0.8	0.9	2.5	-1.6	-0.1	0.6	0.7	-1.2	0.7
Medication: Metformin	0.3	0.4	1.3	-0.6	-0.4	-1.1	-0.5	0.5	-0.6
Diabetes (father)	0.4	0.6	1.4	0.7	-0.9	-0.3	0.6	-1.2	0.4
Diabetes (mother)	0.6	0.8	1.4	-1.2	0.3	-0.9	-1.1	0.8	-0.6
Severe depression (siblings)	1.1	1.2	2.3	0.0	-0.3	1.2	1.5	-1.3	1.4
Pack years adult smoking proportion	2.1	3.2	7.8	0.4	0.0	-2.0	-2.8	1.9	-1.8
Impedance of leg (right)	2.2	10.8	17.2	-0.8	2.7	-4.1	-3.8	3.2	-3.9
Leg fat-free mass (left)	0.9	5.0	12.4	-0.3	-2.6	2.3	1.6	-3.5	1.7
Trunk fat percentage	0.8	3.1	5.3	-1.8	-1.5	-2.3	-1.7	0.3	-2.3
Hand grip strength (right)	1.1	3.0	5.7	0.9	2.4	2.0	1.3	-1.8	1.6
Townsend deprivation index at recruitment	0.6	0.9	2.9	0.4	-0.4	1.7	0.0	-0.6	1.4
Current tobacco smoking	0.2	0.2	0.5	0.4	-0.6	-0.1	-0.7	-0.7	-0.1
Average weekly fortified wine intake	2.2	2.5	4.7	1.4	0.8	2.2	1.5	-1.6	1.7
Maternal smoking around birth	1.3	1.8	7.3	1.3	-2.7	1.2	-0.2	-0.2	0.5
Fed-up feelings	0.1	0.2	0.6	0.0	-0.4	0.6	0.6	-0.7	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	3.3	0.5	1.8	0.3	-0.3	0.3	0.7
Relative age voice broke	1.9	3.0	7.3	-0.2	-0.1	-2.7	-0.9	1.6	-2.6
Taking other prescription medications	0.8	1.2	1.9	-1.0	1.2	-1.3	-1.4	0.9	-0.6
Age when periods started (menarche)	0.4	1.0	2.4	0.6	0.7	-0.4	-1.6	1.2	-1.1
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	9.0	3.0	-1.4	1.6	-0.5	-1.0	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.5	-0.7	1.9	-0.4	0.2	0.0	-0.2
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.2	-0.7	-1.0	0.8	1.1	-1.8	1.6
Qualifications: CSEs or equivalent	1.1	1.4	3.2	-0.0	-1.5	1.8	0.7	-1.0	1.2
Serious illness, injury or assault to yourself	0.3	0.4	1.2	0.3	-0.4	1.1	-0.2	-0.2	0.9
High blood pressure	0.3	0.9	2.2	0.1	-0.6	-1.5	0.1	0.8	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.8	-0.7	1.7	0.3	-0.5	0.3	0.0
Multivitamins +/- minerals	1.3	1.6	3.2	-1.6	-0.1	-1.8	-1.0	0.7	-1.5
Stomach or abdominal pain in last month	1.4	1.7	3.8	-2.0	-1.1	1.3	1.0	-0.3	1.5
Supplements: Glucosamine	2.9	3.8	8.5	1.2	-1.0	2.4	2.9	-1.6	1.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.4	0.9	-1.5	0.8	0.6	0.1	0.3
Medication: Atenolol	1.4	1.8	3.6	0.3	0.6	-0.9	-1.6	1.7	-1.9
Medication: Levothyroxine sodium	0.9	1.5	2.9	0.1	-0.1	-1.2	-1.6	1.7	-1.4
Sitting height	0.4	3.2	11.3	-3.4	-1.7	0.1	-0.3	-2.2	-0.2
Chronic bronchitis/emphysema (father)	1.2	1.4	3.0	-0.7	1.7	0.9	-0.6	-1.6	1.2
High blood pressure (mother)	0.2	0.3	0.6	0.7	-0.6	-0.0	0.8	-0.4	0.4
Body mass index (BMI)	0.1	0.5	1.6	-0.7	-1.3	-0.6	-0.4	-0.3	-0.4
Impedance of leg (left)	2.0	9.7	13.6	-0.5	2.7	-3.7	-3.3	3.6	-3.6
Leg predicted mass (left)	0.9	4.9	12.4	-0.4	-2.6	2.2	1.6	-3.5	1.7
Trunk fat mass	0.4	1.8	3.1	-1.8	-1.6	-1.3	-1.0	-0.6	-1.4
Waist circumference	0.2	0.7	2.2	-1.5	-0.7	-0.7	-0.7	-0.4	-0.5
Number of incorrect matches in round	2.5	4.1	6.6	-1.3	-1.5	-2.5	-2.4	1.2	-2.6
Past tobacco smoking	0.2	0.4	0.9	0.6	-0.4	-0.8	-0.1	0.8	-0.9
Alcohol usually taken with meals	0.4	0.6	2.8	0.3	-0.4	0.2	1.7	-0.2	0.5
Nervous feelings	0.6	1.1	2.1	-0.4	-0.0	1.0	1.4	-1.2	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.4	-0.0	-0.8	0.5	1.0	-0.2
Hearing difficulty/problems with background noise	0.3	0.4	2.2	0.3	-1.5	0.1	0.3	0.2	-0.1
Hair/balding pattern: Pattern 2	0.5	0.7	2.6	-1.6	1.0	0.4	-0.4	0.1	0.0
Had menopause	2.5	3.1	6.9	1.0	-1.1	1.9	2.0	-2.6	1.6
Had other major operations	0.6	0.8	1.5	-0.3	-0.8	1.1	0.9	-1.2	0.7
Forced vital capacity (FVC)	3.2	12.2	24.4	2.1	-3.0	4.9	2.9	-3.4	4.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	8.2	0.2	2.9	-0.4	0.5	0.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.3	0.2	0.5	0.3	-0.7	0.8
Qualifications: None of the above	0.2	0.4	1.8	-0.5	-0.3	-0.1	0.3	-1.3	0.1
Financial difficulties in last 2 years	0.1	0.2	0.5	-0.7	-0.0	0.6	0.2	-0.2	0.4
Mouth/teeth dental problems	0.2	0.3	0.8	-0.2	0.9	0.5	-0.7	-0.4	0.4
Heart attack	2.4	3.1	5.5	-1.8	0.3	-1.8	-1.9	2.3	-1.6
Allergy	0.7	1.6	3.1	1.4	-1.1	1.1	1.8	-1.2	0.8
Pain all over the body in last month	0.3	0.3	1.3	-0.3	1.1	-0.1	-0.3	-0.4	-0.3
Diabetes (self-reported)	1.1	1.7	3.5	-0.6	-1.3	-1.9	-1.2	1.3	-1.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.8	0.5	1.7	0.7	0.0	-0.5	0.5
Medication: Ramipril	0.1	0.1	0.6	0.8	-0.0	-0.0	0.2	0.2	-0.3
Medication: Simvastatin	1.3	1.9	3.2	-0.1	0.8	-1.7	-1.3	1.8	-1.6
Fluid intelligence score	0.3	0.7	1.9	-0.5	0.3	0.5	1.4	0.1	1.2
Illnesses of siblings	1.6	2.3	5.0	2.2	-1.2	1.9	1.4	-1.2	0.7
Neuroticism score	0.1	0.1	0.3	-0.6	-0.2	0.5	0.2	-0.2	0.2
Weight	0.3	1.4	4.0	-1.3	-1.5	0.5	0.3	-2.0	0.4
Impedance of arm (right)	0.6	3.0	5.0	-1.5	0.6	-2.1	-2.0	1.3	-2.2
Arm fat percentage (right)	0.7	2.6	4.5	-1.8	-1.1	-2.1	-1.5	0.4	-2.0
Trunk fat-free mass	0.7	4.3	10.6	-0.2	-0.7	2.5	1.6	-3.2	2.4
Hip circumference	0.2	0.7	1.5	-1.0	-1.1	0.3	0.0	-1.2	0.3
Time employed in main current job	0.6	0.7	1.6	1.2	0.7	1.2	0.6	-0.3	0.7
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.6	0.0	0.9	0.5	-0.4	0.9
Father’s age at death	1.2	1.6	3.2	-1.6	-0.7	0.9	1.8	-0.6	1.5
Worrier / anxious feelings	1.9	3.6	7.9	-0.5	-0.4	2.5	2.2	-1.5	2.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	4.6	-1.8	2.1	-1.5	-1.5	0.9	-1.4
Falls in the last year	0.4	0.6	2.4	0.7	-1.5	0.4	0.2	0.6	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.7	0.5	-0.0	-0.5	-0.7	-0.0
Number of live births	0.5	0.7	3.4	1.8	-0.9	0.3	0.0	0.0	0.3
Forced expiratory volume in 1-second (FEV1)	4.2	14.2	24.6	3.1	-2.6	5.0	3.8	-3.7	4.0
Pulse rate	1.3	2.3	5.7	-0.0	-2.4	-1.5	0.2	1.9	-1.3
Happiness	0.3	0.4	0.9	-0.9	0.5	-0.3	0.4	0.8	0.5
Noisy workplace	1.7	2.1	4.4	-0.5	-1.0	-1.8	-1.1	1.5	-2.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.9	0.3	0.8	0.1	1.0	0.4	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.9	-0.2	-1.4	0.2	-0.2	0.9	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	-1.0	-0.8	-0.4	0.6	-0.0	0.5
Asthma	0.8	1.7	4.0	-1.8	0.8	-1.2	-2.0	0.5	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.1	1.0	-0.7	0.3	-0.3	0.4	-0.4
Medication: Cholesterol lowering	0.6	0.9	3.4	-0.1	-0.5	-0.8	-0.8	1.8	-0.8
Depression (self-reported)	1.0	1.2	4.0	-2.0	0.0	-0.8	-0.9	-1.1	-0.9
Medication: Lansoprazole	1.2	1.4	3.9	0.1	1.0	-0.7	-2.0	-0.1	-1.6
Prospective memory result	0.9	1.2	2.2	-0.4	-1.0	-1.5	-1.3	1.0	-1.0
Lung cancer (father)	0.8	1.0	2.2	-0.8	-0.3	-0.8	-1.5	1.2	-0.8
Illnesses of mother	0.8	1.0	2.0	-1.4	0.5	-1.1	-0.7	1.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.7	17.9	2.5	-2.1	4.2	3.3	-2.6	3.4
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	-0.8	-0.6	0.3	0.2	-1.4	0.3
Impedance of arm (left)	0.4	1.7	2.7	-1.7	0.0	-1.6	-1.3	0.6	-1.6
Arm fat mass (right)	0.3	1.2	2.5	-1.4	-1.6	-1.0	-0.7	-0.7	-1.0
Trunk predicted mass	0.8	4.4	11.0	-0.2	-0.6	2.5	1.7	-3.3	2.4
Standing height	0.5	5.1	16.6	-1.3	-0.7	2.5	1.5	-4.1	1.9
Length of working week for main job	0.9	1.0	3.5	-1.2	-1.9	0.6	0.5	0.3	0.6
Exposure to tobacco smoke at home	0.3	0.3	1.0	1.0	-0.3	0.3	0.0	-0.9	-0.3
Breastfed as a baby	0.4	0.4	0.7	0.7	-0.7	0.8	0.7	-0.6	0.4
Tense / ‘highly strung’	0.5	0.8	1.1	1.0	0.8	-0.5	-1.0	1.1	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.2	-1.2	1.5	1.5	0.3	-1.8	1.3
Hair/balding pattern: Pattern 4	0.4	1.0	4.8	-0.5	0.3	0.7	-0.4	-2.2	0.8
Birth weight of first child	0.6	1.1	4.0	0.2	-1.1	0.5	2.0	-1.1	0.3
Peak expiratory flow (PEF)	4.7	10.9	17.7	1.8	-2.0	4.2	3.2	-4.0	3.8
Pulse wave reflection index	1.3	1.6	4.1	0.2	1.5	1.2	0.0	-2.0	1.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.7	0.8	-0.1	0.0	0.2	-0.1	0.3
Loud music exposure frequency	0.5	0.6	1.5	0.1	0.3	0.8	1.2	-0.8	0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	-0.8	-0.4	0.3	-0.0	0.9	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	1.0	0.3	0.2	0.3	1.0	-0.4	-0.1
Blood clot in the leg (DVT)	2.9	3.8	9.0	-0.5	-1.4	-1.7	-3.0	2.1	-2.1
Medication: Paracetamol	0.3	0.4	1.3	0.3	-1.1	0.4	-0.6	0.4	-0.7
Headache pain in last month	0.1	0.2	0.7	-0.1	-0.9	-0.0	-0.2	0.8	0.1
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.0	0.0	1.3	1.7	1.3	-1.7	1.7
Glaucoma (self-reported)	0.9	1.1	3.7	1.0	1.9	0.9	-0.4	-0.7	0.5
Gout (self-reported)	1.2	1.6	3.4	1.7	1.4	-0.2	-0.6	1.9	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.4	-0.5	-0.6	-1.0	0.4	-0.6
Medication: Amlodipine	0.7	1.0	2.7	1.0	0.7	0.9	0.5	-1.6	0.9
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.5	-0.9	2.1	0.6	1.0	-0.7	1.0
Birth weight	0.9	2.0	7.5	2.7	-0.9	1.6	0.3	-0.8	0.5
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.1	-0.7	-1.6	-0.4	0.2	1.8	-0.2
High blood pressure (siblings)	1.6	2.3	5.0	-2.2	0.6	-1.9	-1.4	1.0	-1.2
Forced vital capacity (FVC), Best measure	2.1	7.6	15.1	1.7	-2.2	3.9	2.8	-2.0	3.3
Body fat percentage	0.9	3.6	6.8	-1.7	-1.2	-2.6	-1.9	0.7	-2.5
Leg fat percentage (right)	1.5	5.3	11.8	-1.8	0.1	-3.4	-2.4	1.7	-2.8
Arm fat-free mass (right)	0.8	3.9	8.8	0.3	-1.4	2.4	1.6	-3.0	2.0
Exposure to tobacco smoke outside home	0.5	0.6	2.1	1.5	0.7	0.0	-0.8	0.1	-0.6
Comparative body size at age 10	0.6	1.6	3.4	0.5	-0.9	0.9	1.8	-1.8	1.2
Number of full brothers	0.3	0.4	2.0	1.4	0.0	-0.2	0.7	-0.3	0.0
Worry too long after embarrassment	1.2	2.0	3.3	1.8	-1.7	1.7	1.1	-0.3	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	4.2	-2.1	0.4	0.0	-0.5	-0.8	0.9
Wheeze or whistling in the chest in last year	0.5	0.8	3.0	-1.7	0.5	0.3	-0.5	-0.2	1.2
Number of children fathered	0.6	0.7	2.1	-0.9	-0.9	-0.5	1.5	0.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.6	0.1	0.0	-0.0	-0.1	-0.5
Age at first live birth	1.0	1.8	5.2	1.6	-1.4	0.6	2.3	-0.1	0.6
Pulse wave peak to peak time	0.3	0.3	1.0	0.9	0.4	0.0	-0.1	1.0	-0.1
Health satisfaction	0.1	0.2	0.8	0.4	-0.2	0.1	-0.3	0.9	0.0
Shortness of breath walking on level ground	0.6	0.8	2.5	0.6	-1.6	0.1	1.2	0.5	0.2
Qualifications: College or University degree	0.1	0.2	0.5	-0.7	0.3	-0.1	0.7	0.4	-0.1
Eye problems/disorders: None of the above	2.5	2.9	4.6	1.2	-1.7	1.6	2.1	-2.0	1.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	0.5	-0.1	-0.0	0.9	0.4	0.1
Emphysema/chronic bronchitis	0.8	0.9	2.7	-0.1	0.0	0.6	1.5	0.0	1.6
Medication for pain relief, constipation, heartburn	1.5	2.5	4.3	-1.3	1.1	0.9	1.9	-2.1	1.8
Neck or shoulder pain in last month	0.9	1.3	3.4	-1.9	-1.5	-1.2	-0.0	0.8	-0.5
Medication: Blood pressure	0.9	1.6	3.0	0.6	-1.0	-1.5	-0.6	1.6	-1.7
Angina (self-reported)	0.5	0.6	2.3	0.2	0.8	-0.6	0.6	1.5	-0.4
Migraine (self-reported)	0.5	0.6	1.7	1.3	-0.2	0.0	-0.1	1.1	-0.8
Medication: Ibuprofen	0.6	0.7	1.5	0.7	-0.9	-0.4	-0.7	0.6	-1.2
Medication: Allopurinol	0.4	0.6	2.0	1.4	0.9	0.6	-0.2	0.6	0.1
Medication: Omeprazole	0.5	0.6	1.2	-0.2	-1.0	-0.7	-1.1	0.7	-0.6
Medication: Seretide 50 evohaler	0.4	0.4	1.4	0.2	1.2	0.7	0.3	0.5	0.7
Mean time to correctly identify matches	4.3	8.2	16.1	-1.0	1.4	-3.3	-4.0	2.8	-3.3
Heart disease (mother)	0.5	0.7	2.7	-0.5	1.7	0.2	-0.2	-0.9	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.4	0.6	-0.6	1.8	0.1	-1.8	1.0
Whole body fat mass	0.4	1.7	2.5	-1.5	-1.6	-1.4	-1.1	-0.3	-1.4
Leg fat mass (right)	0.5	2.0	3.6	-1.6	-0.8	-1.9	-1.4	0.4	-1.7
Arm predicted mass (right)	0.7	3.7	8.8	0.7	-1.3	2.3	1.5	-3.0	1.8
Pulse rate, automated reading	1.0	3.1	7.0	-1.5	-2.6	-2.2	0.2	1.6	-1.2
Alcohol intake frequency.	0.2	0.6	1.3	-0.7	0.1	1.1	-0.7	-0.1	1.1
Comparative height size at age 10	1.5	8.5	23.8	-1.1	-1.9	3.3	1.8	-4.9	2.9
Number of full sisters	0.8	1.0	2.1	0.5	-1.5	1.2	0.9	-0.2	1.1
Suffer from ‘nerves’	1.2	1.9	4.8	0.4	-0.8	2.2	1.1	-1.4	1.6
Overall health rating	0.4	0.8	1.8	-0.9	0.1	-0.9	-1.3	0.7	-1.0
Chest pain or discomfort	1.1	1.6	5.9	-0.3	-2.4	-0.2	0.9	1.6	0.3
Had major operations	0.3	0.3	0.7	0.1	-0.3	0.7	0.5	0.7	0.9
Age at last live birth	0.6	0.8	2.5	1.4	-0.2	0.7	1.6	0.1	0.3
Family relationship satisfaction	0.3	0.3	1.3	-0.6	-0.1	-0.2	-0.4	1.1	0.3
Leg pain on walking	0.1	0.1	0.3	0.2	0.1	-0.1	0.5	0.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.3	0.6	0.4	0.6	0.3	0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	-0.8	0.9	-0.3	-0.3	0.8	-0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.0	1.4	0.0	-0.1	0.6	-0.9	0.0
Medication: Aspirin	2.9	3.8	9.5	-0.3	0.7	-2.3	-1.8	3.1	-2.1
Supplements: Vitamin C	0.9	1.0	1.6	-1.3	-1.2	-0.7	-1.2	0.6	-0.9
Knee pain experienced in last month	1.2	1.8	3.9	2.0	-1.7	1.2	1.3	-0.9	0.6
Hypertension (Self-reported)	0.2	0.6	2.2	0.2	-0.4	-1.1	0.1	0.5	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	1.1	0.7	0.6	-0.1	-0.3	0.1
Illnesses of father: Heart disease	1.1	1.5	2.9	-0.5	1.7	-1.2	-1.5	0.6	-1.4
Illnesses of siblings: Diabetes	0.9	1.1	4.5	-2.1	-0.0	-0.8	0.5	1.0	0.4
Smoking status: Previous	0.3	0.4	1.4	-1.2	0.6	0.1	0.3	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	3.2	-1.4	-0.4	-0.3	0.4	-1.8	0.3
Whole body fat-free mass	0.9	4.9	11.8	-0.2	-1.6	2.6	1.8	-3.4	2.3
Leg fat-free mass (right)	1.2	6.7	13.8	-0.1	-2.6	3.0	2.2	-3.7	2.4
Arm fat percentage (left)	0.6	2.2	3.7	-1.8	-1.3	-1.9	-1.2	0.3	-1.8
Average weekly red wine intake	1.8	2.6	7.1	1.7	0.0	1.4	2.7	-0.7	1.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.8	1.1	0.1	1.4	-0.4	-0.1	0.7
Mood swings	0.2	0.4	2.0	-0.3	-1.4	0.2	-0.0	-0.6	-0.1
Loneliness, isolation	0.6	0.8	1.4	-1.1	1.2	-0.7	-0.9	0.9	-0.2
Long-standing illness, disability or infirmity	0.3	0.4	0.9	-0.9	-0.2	0.0	0.6	1.0	0.5
Ever had bowel cancer screening	1.2	1.4	2.5	1.2	1.0	1.6	0.9	-0.7	1.4
Diabetes diagnosed by doctor	1.5	2.5	3.7	-0.8	-1.9	-1.9	-1.3	1.7	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.4	0.4	0.4	0.2	0.0	0.2
Friendships satisfaction	0.4	0.5	1.6	0.0	1.3	-0.4	0.4	1.1	0.0
Qualifications: nursing, teaching	0.2	0.4	0.8	0.6	0.6	0.8	0.0	-0.3	0.9
Commuting to job workplace: Walk	0.3	0.3	1.0	-0.3	-0.7	0.1	0.4	-1.0	0.4
Eye problems/disorders: Cataract	2.0	2.3	6.1	-1.1	0.4	-1.5	-1.2	2.5	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	4.4	1.5	-0.8	-1.0	-1.2	1.6	-2.1
Medication for cholesterol	0.1	0.2	0.8	0.1	0.1	-0.3	-0.2	0.9	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	6.0	1.0	0.1	0.1	-2.5	0.2	-1.3
Back pain experienced in last month	0.8	1.2	2.4	0.7	0.3	-1.0	-1.5	1.2	-1.3
Mineral and other dietary supplements	0.4	0.5	1.3	0.2	-0.8	-1.2	-0.6	-0.1	-0.8
Breast cancer (self-reported)	0.2	0.3	0.8	0.3	0.0	0.1	0.5	-0.9	0.8
Asthma (self-reported)	0.8	1.7	3.7	-1.9	1.1	-1.0	-1.9	0.6	-0.2
Osteoporosis (self-reported)	1.3	1.6	5.9	0.7	2.4	0.7	0.4	-1.2	1.0
Osteoarthritis (self-reported)	1.0	1.3	2.0	0.4	-1.2	1.3	1.4	-1.1	1.2
Medication: Aspirin	2.6	3.3	9.8	0.4	0.9	-2.0	-1.4	3.1	-1.8
Medication: Gliclazide	0.6	0.6	2.7	-0.3	-1.6	0.5	0.3	-0.0	0.9
Illnesses of father: None of the above (group 1)	0.7	0.8	1.8	-0.4	1.1	-0.4	-1.1	1.3	-0.5
Smoking status: Current	0.4	0.6	1.8	0.5	-0.6	0.9	-0.1	-1.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	7.1	2.0	-0.3	2.7	1.8	-1.3	2.6
Whole body water mass	0.9	5.1	11.9	0.0	-1.6	2.7	1.9	-3.5	2.3
Leg predicted mass (right)	1.3	6.7	14.0	-0.1	-2.6	3.0	2.2	-3.7	2.4
Arm fat mass (left)	0.3	1.1	2.3	-1.4	-1.5	-0.8	-0.6	-0.7	-0.7
Number of self-reported non-cancer illnesses	0.0	0.1	0.3	0.3	0.2	0.0	-0.5	0.0	-0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.6	-0.3	-0.1	0.9	0.5	-0.4
Miserableness	0.0	0.0	0.1	-0.2	0.1	-0.1	0.3	0.3	-0.2
Guilty feelings	0.3	0.4	0.9	-0.6	-0.1	0.6	0.9	-0.4	1.0
Wears glasses or contact lenses	0.5	0.5	2.0	0.2	0.9	0.4	-1.4	-0.4	-0.3
Ever taken oral contraceptive pill	0.3	0.4	1.1	-1.1	-0.2	-0.4	-0.5	0.8	-0.3
Hearing aid user	0.3	0.3	0.9	0.8	-0.9	-0.5	0.3	0.3	-0.3
Mother’s age at death	1.7	2.2	12.2	-0.1	-3.5	-0.4	-0.2	0.6	-0.5
Financial situation satisfaction	0.2	0.2	0.7	0.1	0.8	0.6	0.3	0.2	0.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.8	-0.2	-0.5	1.4	0.6	-1.7	1.1
Commuting to job workplace: Public transport	0.5	0.6	2.8	0.1	-1.7	0.4	-0.3	-0.2	0.4
Eye problems/disorders: Glaucoma	1.0	1.2	5.2	0.3	2.3	0.1	-1.4	0.2	-0.3
Medication: Blood pressure	0.2	0.3	0.7	0.3	0.9	0.1	0.4	-0.8	-0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.7	-0.9	-1.2	0.2	1.6	-0.6	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	-1.1	1.1	0.0	-0.4	0.4	0.2
High cholesterol (Self-reported)	0.7	1.2	2.0	-0.4	0.9	-1.3	-1.4	1.3	-0.8
Medication: Bendroflumethiazide	0.4	0.6	1.9	-0.1	-1.4	-0.7	0.0	-0.8	-0.9
Medication: Paracetamol	0.3	0.4	1.1	1.0	-0.6	0.8	-0.5	0.1	-0.3
Medication: Lisinopril	1.8	2.3	4.9	-0.4	0.1	-2.0	-1.6	1.4	-2.2
Medication: Atorvastatin	0.8	1.0	4.2	-0.2	0.4	-0.8	-0.6	2.0	-0.8
Illnesses of father: High blood pressure	0.5	0.6	1.9	-0.9	-1.4	-0.6	-0.2	-0.4	-0.8
Alcohol drinker status: Never	0.9	1.1	2.2	-1.4	0.3	-1.5	-0.9	0.9	-1.0
Ever smoked	0.3	0.5	1.2	-0.6	-0.4	0.7	-0.0	-1.1	1.0
Basal metabolic rate	0.7	3.8	9.9	-0.3	-1.7	2.1	1.4	-3.1	1.8
Leg fat percentage (left)	1.0	3.7	8.2	-1.6	-0.1	-2.9	-1.9	1.6	-2.4
Arm fat-free mass (left)	0.5	2.6	6.8	0.3	-1.0	2.0	1.2	-2.6	1.6
Number of operations (self-reported)	0.3	0.5	1.0	0.4	-1.0	0.8	0.0	1.0	0.5
Average weekly beer plus cider intake	0.7	1.0	3.7	-1.9	1.3	-0.4	-0.0	0.4	-0.3
Irritability	0.1	0.2	0.8	-0.3	-0.3	-0.9	0.5	-0.1	-0.4
Risk taking	0.5	0.7	2.0	-0.1	0.3	-1.2	-1.4	-0.2	-0.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.8	0.4	0.8	0.2	-0.9	0.7	0.1
Fractured/broken bones in last 5 years	1.1	1.4	3.1	-0.5	-1.8	-1.6	-0.8	0.6	-1.1
Age started oral contraceptive pill	0.1	0.1	0.3	0.6	-0.1	0.3	-0.4	-0.3	-0.2
Diastolic blood pressure, automated reading	0.4	1.2	2.5	-0.9	-0.9	0.4	1.5	-1.6	0.8
Ever depressed for a whole week	0.7	0.8	1.7	0.9	0.1	1.3	0.7	-1.2	0.8
Unable to work because of sickness or disability	2.5	3.2	5.7	-1.6	0.1	-2.4	-1.6	2.1	-2.0
Commuting to job workplace: Cycle	1.3	1.5	2.3	1.4	-0.3	1.3	1.5	-1.1	1.3
Myopia	1.8	2.6	4.4	-0.4	-1.5	1.8	2.1	-1.9	1.3
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.7	0.4	0.3	1.9	0.5	-1.3	1.9
Cholesterol lowering medication	1.1	1.6	2.5	-1.3	1.4	-1.6	-1.0	0.8	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	-0.2	-1.1	-0.3	-0.9	0.1	-0.2
Pain experienced in last month	0.2	0.4	1.0	-0.4	0.8	0.3	-0.2	-0.5	1.0
Supplements: Calcium	0.1	0.1	0.2	0.2	-0.1	0.3	0.4	0.1	-0.2
Basal cell carcinoma (self-reported)	0.7	0.9	3.0	1.7	0.2	1.0	0.6	0.9	0.3
Heart attack/myocardial infarction (self-reported)	2.3	2.9	4.8	-1.7	0.5	-1.9	-1.8	2.2	-1.6
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	8.5	-0.4	-1.9	-1.5	-2.9	1.7	-2.0
Heart disease (siblings)	0.9	1.1	2.4	-0.2	0.5	-1.5	-0.9	1.3	-1.3
Alcohol drinker status: Previous	1.4	1.6	3.8	0.3	-0.9	-1.1	-2.0	1.3	-1.5
Pack years of smoking	1.9	2.7	6.5	0.3	0.0	-1.8	-2.5	1.9	-1.6
Impedance of whole body	1.1	5.8	9.7	-1.3	1.3	-3.1	-2.6	2.3	-3.1
Leg fat mass (left)	0.4	1.4	2.3	-1.3	-1.0	-1.5	-1.1	0.3	-1.4
Arm predicted mass (left)	0.7	3.8	9.5	0.4	-1.1	2.3	1.5	-3.1	2.1