Hub : Genes

CSTF3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0769	0.0408	9.5e-03	0.061	NA	0.062	NA	0.086	4.0e-05	NA	3.3e-05	NA	1.2e-06
2	METSIM	Adipose	0.0613	0.0199	4.2e-06	0.009	0.041	0.029	0.039	0.024	1.6e-02	8.9e-07	3.3e-05	1.5e-06	1.2e-04
3	NTR	Blood	0.0469	0.0140	6.8e-14	0.053	0.046	0.046	0.048	0.051	1.3e-16	1.1e-14	1.6e-14	3.6e-15	4.6e-16
4	YFS	Blood	0.1328	0.0323	1.9e-12	0.018	0.049	0.072	0.076	0.037	9.3e-07	1.5e-15	1.2e-22	1.3e-23	3.8e-12
5	TCGA	Thyroid Carcinoma	0.0330	0.0190	6.4e-04	0.024	0.035	0.025	NA	0.022	2.1e-03	2.4e-04	1.5e-03	NA	2.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	1.3	-0.4	0.4	0.1	-1.0	-1.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.5	-0.3	1.6	0.0	-1.5	-0.2
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	-1.0	0.6	0.1	-0.4	-0.2
Depression (Nagel 2018)	2.1	3.2	5.1	1.7	0.3	-2.3	-2.0	-1.9
Intelligence (Savage-Jansen 2018)	1.0	3.1	6.2	-0.8	2.1	2.5	-0.2	2.0
Neuroticism (Nagel 2018)	0.4	0.9	2.7	-0.9	1.7	0.8	0.1	0.7
Schizophrenia (2018)	0.4	0.9	2.9	-0.1	1.7	-0.0	-1.1	0.6
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	-0.5	-0.3	0.6	-0.1	0.7
Worry (Nagel 2018)	0.2	0.5	1.8	0.2	1.3	0.1	-0.1	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	1.6	1.2	1.3	-0.6	-0.7	0.4
Alzheimer’s Disease (in father)	0.3	0.4	0.9	0.5	-0.7	-0.9	-0.1	-0.4
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	1.4	0.5	-1.5	-0.5	-0.4
Crohns Disease (2017)	0.5	1.2	2.7	0.0	-0.9	-1.6	1.0	-1.2
Irritable Bowel Disease (IBD)	0.5	1.3	2.9	1.1	-0.6	-1.7	-0.7	-1.3
Ulcerative Colitis (UC)	0.9	1.6	3.5	1.4	-0.3	-1.2	-1.9	-1.0
Major Depression (MDD)	0.1	0.2	0.4	-0.0	-0.4	0.4	-0.6	0.3
Reaction Time	4.0	7.6	14.1	2.3	-2.4	-2.8	-2.2	-3.7
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.9	-0.1	2.6	0.8	-1.3	0.2
Breast Cancer	1.3	3.2	4.7	-1.1	2.2	1.8	1.8	2.0
Ovarian Cancer	1.6	2.2	3.9	-0.7	1.9	1.6	0.4	2.0
Prostate Cancer	0.9	1.2	2.9	-1.2	1.7	0.7	0.5	0.9
Age at First Birth	0.5	0.7	1.1	-0.7	0.8	1.1	0.1	1.1
Bipolar Disorder (2011)	0.7	0.7	1.7	-1.1	1.3	0.4	-0.4	-0.3
Body Mass Index (BMI) (2010)	1.1	1.6	3.2	-1.5	0.0	1.4	-1.8	0.6
Coronary Artery Disease (CAD)	2.1	2.5	5.1	0.7	-1.4	-2.3	-0.7	-2.1
Crohns Disease (2012)	0.2	0.3	0.7	-0.4	-0.2	-0.9	0.3	-0.7
Mean Putamen Volume	1.2	1.3	2.9	-0.4	-0.4	1.0	1.6	1.7
Fasting Glucose	0.2	0.3	0.5	-0.6	0.2	-0.5	0.5	-0.7
HbA1C	0.1	0.2	0.4	-0.5	0.2	0.2	0.0	0.7
HDL Cholesterol	1.1	1.9	2.8	-0.6	1.7	1.5	1.4	1.4
LDL Cholesterol	0.2	0.3	0.6	0.4	0.7	-0.8	0.2	-0.5
Lupus	2.1	3.2	5.5	1.5	-2.3	-1.5	-1.0	-2.2
Neuroticism (2016)	1.0	1.4	6.0	0.7	2.4	-0.2	0.5	0.6
Primary Biliary Cirrhosis	0.4	0.5	1.4	0.9	1.2	0.1	-0.6	-0.1
Rheumatoid Arthritis	0.4	0.6	1.2	-1.1	-0.2	-0.1	-0.9	-0.9
Schizophrenia (2014)	0.3	0.6	1.5	0.2	1.1	-0.2	-1.2	0.2
Triglycerides	0.1	0.1	0.2	0.4	-0.4	-0.1	0.2	-0.1
Type 2 Diabetes (T2D) (2012)	2.8	3.3	7.7	-1.1	-0.9	-1.5	-2.0	-2.8
Ulcerative Colitis	3.2	4.6	9.1	2.0	-0.9	-2.1	-3.0	-2.2
Blood Eosinophil Count	0.4	2.9	12.0	-0.8	-0.2	1.2	-3.5	-0.4
Blood Platelet Count	0.3	3.3	4.9	-0.7	2.2	1.3	2.2	2.2
Blood Red Count	0.1	1.1	3.5	1.9	0.3	-1.0	-0.7	0.6
Blood White Count	0.3	2.6	5.6	0.6	-1.1	-1.6	-1.7	-2.4
Heel T-Score	1.2	9.3	19.6	2.4	-3.3	-4.4	-0.4	-3.1
BMI	0.7	4.2	13.6	-0.7	-1.2	-0.8	-3.7	-2.1
Height	0.9	17.3	40.8	-2.0	3.3	3.8	6.4	4.1
Waist Hip Ratio (WHR)	0.7	3.3	6.0	2.5	0.4	-2.1	-0.6	-2.3
Systolic Blood Pressure	0.2	1.0	4.2	-0.1	-0.3	-0.4	-2.0	-0.6
Smoking Status	0.1	0.1	0.4	0.3	0.2	0.4	-0.7	0.1
Allergy or Eczema	0.2	0.4	1.5	0.4	0.5	-1.2	-0.3	-0.5
Cardiovascular Disease	0.9	2.9	9.4	0.7	-0.9	-1.1	-3.1	-1.6
Hypothyroidism (self reported)	0.8	1.9	6.0	0.8	-2.5	-1.0	0.2	-1.5
Respiratory disease	0.0	0.1	0.2	0.2	0.3	0.2	-0.5	-0.1
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.5	0.1	-1.2	-1.1	-0.2	-1.6
Lung FEV1/FVC ratio	0.2	1.3	3.5	1.7	-0.0	-0.2	-1.9	0.1
Lung FVC	0.8	4.1	11.2	1.6	3.4	-0.4	1.8	1.8
Neuroticism	0.2	0.5	1.9	-0.1	1.4	0.4	0.2	0.7
Chronotype (morning person)	1.5	3.4	5.1	-2.0	-2.2	-0.4	-1.7	-2.2
Hair Pigment	0.0	0.3	0.6	0.3	0.6	-0.8	0.1	-0.6
Tanning	0.1	1.0	3.5	0.7	-1.9	-0.7	0.2	-0.8
Hand grip strength (left)	0.6	1.6	4.9	1.2	0.8	-0.6	2.2	0.9
Number of treatments/medications taken	0.9	1.7	3.1	0.6	0.5	-1.7	-1.8	-1.4
Average weekly spirits intake	0.7	0.9	1.6	0.7	0.6	-0.5	1.3	-1.2
Sensitivity / hurt feelings	1.4	2.4	5.0	-0.9	2.2	1.7	0.9	1.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.4	1.0	0.5	-1.2	-1.6	-1.1
Hearing difficulty/problems: Yes	0.5	0.7	1.5	-1.2	0.1	1.1	0.2	0.9
Relative age of first facial hair	4.9	10.0	14.0	2.8	-3.0	-3.7	-2.5	-3.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	1.7	1.2	1.1	0.6	-1.3	1.2
Ever used hormone-replacement therapy (HRT)	1.2	1.6	5.0	0.5	1.5	0.1	2.2	0.7
Ever had hysterectomy (womb removed)	1.5	1.7	2.8	-1.2	0.9	1.4	1.2	1.7
Systolic blood pressure, automated reading	0.5	1.4	5.3	-1.0	0.0	0.5	-2.3	0.4
Eye problems/disorders: Diabetes related eye disease	4.2	4.6	7.6	2.3	-1.8	-2.8	-0.5	-2.6
Angina	0.4	0.5	1.1	0.5	-0.0	-1.0	-0.4	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.6	0.1	0.0	0.6	-0.4
Vitamin and mineral supplements	1.0	1.4	4.3	0.4	0.7	1.2	0.8	2.1
Supplements: Zinc	1.3	1.4	5.5	-1.1	-0.1	0.5	2.3	0.0
Medication: Co-codamol	0.3	0.4	1.4	0.2	1.2	0.0	-0.6	0.4
Medication: Metformin	0.2	0.3	0.6	-0.8	-0.2	-0.2	-0.6	-0.7
Diabetes (father)	0.6	0.8	2.9	-1.7	0.3	0.8	-0.5	0.1
Diabetes (mother)	1.5	1.9	5.4	0.8	-0.7	-2.3	-0.9	-1.4
Severe depression (siblings)	1.4	1.6	3.5	-1.9	-0.1	1.3	0.8	1.4
Pack years adult smoking proportion	1.6	2.4	5.8	0.2	-1.5	-1.5	-1.3	-2.4
Impedance of leg (right)	1.0	4.7	11.3	1.6	-2.5	-1.9	-0.2	-3.4
Leg fat-free mass (left)	0.5	2.8	4.0	-1.8	1.8	1.4	1.3	2.0
Trunk fat percentage	0.5	2.1	5.2	-1.5	-1.0	-0.0	-2.3	-1.4
Hand grip strength (right)	0.5	1.5	3.3	1.0	0.6	-0.0	1.8	1.6
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.2	0.5	-0.2	0.6	0.5
Current tobacco smoking	0.2	0.4	0.9	-0.4	-0.7	0.4	-0.9	-0.2
Average weekly fortified wine intake	0.8	0.9	2.2	1.0	0.0	-0.3	1.5	1.0
Maternal smoking around birth	1.2	1.7	3.7	1.2	0.0	-1.5	-1.9	-1.1
Fed-up feelings	0.1	0.2	0.5	-0.1	0.7	0.4	0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.0	1.6	0.8	-1.9	-2.0	-0.9
Relative age voice broke	4.4	6.7	10.2	1.3	-2.6	-2.9	-2.6	-3.2
Taking other prescription medications	0.3	0.5	0.9	0.5	0.2	-0.8	-0.9	-1.0
Age when periods started (menarche)	0.8	2.0	3.8	2.0	-0.8	-1.3	1.5	-1.2
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	5.6	-0.6	-0.2	0.8	2.4	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.2	1.3	-1.8	-1.6	-0.7	-1.1
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.6	-1.2	1.6	0.9	1.1	1.1
Qualifications: CSEs or equivalent	1.8	2.4	4.7	-0.4	2.2	1.1	1.7	1.7
Serious illness, injury or assault to yourself	0.2	0.3	0.8	-0.3	0.9	0.4	0.1	0.6
High blood pressure	0.3	1.0	4.2	-0.0	-0.2	-0.2	-2.1	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.2	0.6	-0.9	0.7	0.0
Multivitamins +/- minerals	1.0	1.3	3.0	-0.2	-1.1	-1.1	-1.1	-1.7
Stomach or abdominal pain in last month	0.6	0.7	1.3	1.1	0.9	-1.0	0.8	0.3
Supplements: Glucosamine	0.4	0.6	1.6	0.2	1.3	-0.3	0.2	1.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.9	1.4	-0.2	-1.3	1.2	-0.5
Medication: Atenolol	0.4	0.5	1.2	0.5	0.0	-1.1	-0.7	-0.9
Medication: Levothyroxine sodium	1.7	2.9	6.9	1.4	-2.6	-1.3	-1.3	-1.5
Sitting height	0.3	2.1	9.1	-0.3	1.1	-0.4	3.0	0.1
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	0.9	0.9	-0.0	-0.3	0.4
High blood pressure (mother)	1.7	2.3	4.7	1.6	-1.7	-0.9	-2.2	-0.7
Body mass index (BMI)	0.3	1.1	3.0	-1.4	-0.3	-0.1	-1.7	-0.4
Impedance of leg (left)	1.2	5.7	11.2	2.4	-2.5	-2.3	0.0	-3.3
Leg predicted mass (left)	0.5	2.8	3.9	-1.8	1.8	1.4	1.2	2.0
Trunk fat mass	0.2	1.1	2.8	-1.7	-0.3	0.2	-1.4	-0.6
Waist circumference	0.1	0.5	1.1	-0.9	0.4	-0.3	-1.0	-0.5
Number of incorrect matches in round	1.8	3.0	5.4	-2.3	-2.3	0.9	-1.6	-1.1
Past tobacco smoking	0.2	0.4	1.1	-0.5	-0.5	0.5	-1.0	-0.2
Alcohol usually taken with meals	1.0	1.6	3.2	-1.4	0.9	1.8	-0.9	1.1
Nervous feelings	1.0	1.9	2.4	-1.6	1.5	1.0	-1.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.2	0.6	-0.3	-1.5	-1.3	-1.4
Hearing difficulty/problems with background noise	1.4	2.2	4.1	-1.9	1.4	2.0	-0.3	1.1
Hair/balding pattern: Pattern 2	0.3	0.3	1.5	0.1	1.2	-0.1	0.3	0.3
Had menopause	2.2	2.7	4.1	-0.9	1.5	1.7	1.9	2.0
Had other major operations	1.5	1.9	8.5	-0.4	0.4	0.1	2.9	0.8
Forced vital capacity (FVC)	1.5	5.8	11.7	1.0	3.0	0.6	3.4	2.7
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	6.2	1.8	-2.5	-1.7	-0.4	-1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	-0.1	1.1	0.5	0.3	0.6
Qualifications: None of the above	0.7	1.6	5.8	-1.4	-2.4	-0.3	0.2	-0.1
Financial difficulties in last 2 years	0.3	0.3	1.4	0.2	1.2	-0.5	-0.1	-0.0
Mouth/teeth dental problems	0.3	0.4	0.9	0.9	0.9	0.1	0.4	0.5
Heart attack	1.3	1.6	4.4	-0.4	-0.7	-0.8	-2.1	-1.6
Allergy	0.5	1.2	2.8	-1.0	0.5	1.7	0.6	1.3
Pain all over the body in last month	1.2	1.2	5.1	0.6	-0.2	-0.9	2.3	-0.3
Diabetes (self-reported)	0.5	0.8	2.8	-0.4	-0.3	-0.7	-0.6	-1.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.0	1.7	0.3	-1.3	0.8	0.1
Medication: Ramipril	1.0	1.3	2.7	1.6	0.6	-1.6	0.0	-1.1
Medication: Simvastatin	1.2	1.7	4.0	0.2	-0.8	-1.3	-2.0	-1.5
Fluid intelligence score	0.4	0.9	1.8	-0.5	1.0	1.3	0.0	1.2
Illnesses of siblings	1.2	1.7	3.4	0.1	0.0	1.3	1.8	1.8
Neuroticism score	0.1	0.3	1.1	-0.0	1.0	0.3	-0.0	0.5
Weight	0.2	0.8	2.3	-1.5	0.9	0.7	0.2	0.8
Impedance of arm (right)	0.1	0.4	1.8	-0.5	0.1	1.3	-0.0	-0.4
Arm fat percentage (right)	0.5	1.9	4.7	-1.9	-0.6	0.2	-2.2	-1.0
Trunk fat-free mass	0.4	2.6	5.7	-0.8	1.3	0.7	2.4	2.0
Hip circumference	0.3	1.2	3.4	-1.8	0.6	1.1	-0.3	1.0
Time employed in main current job	0.7	0.9	2.0	0.3	1.0	1.1	0.0	1.4
Alcohol intake versus 10 years previously	1.8	2.6	8.5	-1.4	0.7	0.8	2.9	1.3
Father’s age at death	0.7	0.9	2.1	-0.7	-0.1	1.3	-0.5	1.4
Worrier / anxious feelings	1.1	2.1	5.2	0.1	1.9	1.0	1.0	2.3
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.4	10.3	1.9	0.1	-3.2	-2.4	-2.7
Falls in the last year	0.1	0.1	0.3	-0.1	-0.5	-0.5	-0.0	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	0.2	-1.0	-0.4	-0.7	-0.2
Number of live births	0.9	1.3	3.0	0.4	-0.4	-1.7	-1.3	-1.1
Forced expiratory volume in 1-second (FEV1)	1.6	5.3	9.1	1.2	3.0	0.9	2.6	2.9
Pulse rate	0.6	1.1	1.7	1.1	0.6	-0.7	-1.3	-1.3
Happiness	0.1	0.1	0.2	-0.1	0.5	-0.3	-0.2	-0.2
Noisy workplace	1.6	2.0	4.5	-0.1	-2.1	-1.6	0.1	-1.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.6	-0.2	1.0	1.3	-0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.3	0.4	0.0	0.6	0.2
Mouth/teeth dental problems: Dentures	0.4	0.7	2.2	-1.5	0.3	0.9	-0.7	0.2
Asthma	0.1	0.2	0.3	0.5	-0.3	-0.0	-0.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.3	0.4	0.5	-0.4	0.1
Medication: Cholesterol lowering	0.3	0.4	0.9	-0.5	-0.0	-0.5	-0.9	-0.9
Depression (self-reported)	0.1	0.2	0.3	-0.2	-0.6	-0.2	0.4	-0.5
Medication: Lansoprazole	0.5	0.5	1.3	0.1	-0.8	-1.1	0.1	-0.8
Prospective memory result	1.4	1.7	3.6	-0.9	-1.7	-0.1	1.9	-1.0
Lung cancer (father)	1.7	2.0	5.1	1.0	-0.2	-2.3	-0.8	-1.8
Illnesses of mother	0.9	1.2	5.1	-0.1	0.1	-0.4	2.2	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	8.2	1.2	2.9	0.1	2.2	2.2
Pulse wave Arterial Stiffness index	0.4	0.5	1.2	-0.7	0.1	1.1	0.2	0.9
Impedance of arm (left)	0.1	0.7	2.8	-0.6	0.4	1.7	-0.2	-0.0
Arm fat mass (right)	0.2	0.8	2.3	-1.5	-0.1	0.2	-1.2	-0.4
Trunk predicted mass	0.5	2.8	5.9	-0.9	1.4	0.8	2.4	2.1
Standing height	0.6	6.0	15.0	-0.4	2.3	1.8	3.9	2.6
Length of working week for main job	0.3	0.3	1.4	0.2	1.2	0.2	0.3	0.1
Exposure to tobacco smoke at home	1.1	1.2	4.1	-0.1	-1.3	-0.4	-2.0	-0.4
Breastfed as a baby	0.3	0.4	1.1	0.6	1.0	0.1	-0.1	0.6
Tense / ‘highly strung’	1.2	2.0	3.0	1.5	-0.2	-1.7	-1.7	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	5.2	-1.1	2.3	1.1	0.8	1.6
Hair/balding pattern: Pattern 4	1.6	3.9	7.8	-2.7	0.8	2.8	0.3	1.8
Birth weight of first child	0.1	0.3	0.6	-0.6	-0.8	0.2	0.1	0.5
Peak expiratory flow (PEF)	1.6	3.8	8.4	0.9	2.8	1.1	1.1	2.9
Pulse wave reflection index	0.5	0.6	1.1	-0.3	-1.1	0.6	0.7	1.0
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.1	-0.8	0.2	0.4	-0.0
Loud music exposure frequency	2.4	2.7	3.9	-1.6	1.3	2.0	1.5	1.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.3	-0.8	1.4	1.5	-0.2	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.9	0.4	-0.4	-1.4	-0.2	-0.6
Blood clot in the leg (DVT)	3.5	4.5	7.0	2.3	-1.3	-2.4	-1.7	-2.6
Medication: Paracetamol	0.1	0.1	0.2	0.3	0.5	-0.4	0.3	-0.3
Headache pain in last month	0.2	0.3	0.9	-0.5	1.0	0.2	0.7	0.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	3.4	-0.0	0.4	1.1	1.9	1.8
Glaucoma (self-reported)	0.7	0.8	1.2	-0.7	1.0	0.5	1.1	1.0
Gout (self-reported)	1.0	1.4	2.7	1.2	-0.0	-1.6	-1.2	-1.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.0	1.1	-1.4	-1.1	-0.3	-1.1
Medication: Amlodipine	0.8	1.1	3.2	1.2	1.8	0.1	0.6	0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	0.0	0.5	0.6	1.1	0.8
Birth weight	0.2	0.5	1.0	-0.4	0.0	0.7	1.0	1.0
Chronic bronchitis/emphysema (mother)	2.7	3.1	13.5	1.1	-0.3	-0.2	-3.7	-0.9
High blood pressure (siblings)	1.8	2.6	5.4	0.9	-0.7	-2.1	-1.4	-2.3
Forced vital capacity (FVC), Best measure	1.0	3.6	7.3	1.5	2.7	-0.2	2.4	1.7
Body fat percentage	0.6	2.4	5.7	-1.4	-1.2	-0.3	-2.4	-1.7
Leg fat percentage (right)	1.0	3.7	6.5	-1.0	-1.7	-1.3	-2.5	-2.5
Arm fat-free mass (right)	0.3	1.5	3.5	-0.3	1.4	0.0	1.9	1.4
Exposure to tobacco smoke outside home	1.8	2.4	4.3	1.5	-1.9	-2.1	-0.5	-1.2
Comparative body size at age 10	0.8	2.1	4.1	-2.0	-0.5	1.8	-0.7	1.5
Number of full brothers	0.5	0.6	2.5	-0.6	0.2	-0.3	-1.6	-0.4
Worry too long after embarrassment	0.7	1.1	2.2	0.5	1.5	1.2	-0.1	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.5	-0.7	0.1	0.1	-0.4	0.1
Wheeze or whistling in the chest in last year	0.4	0.7	2.7	-0.1	1.6	0.5	0.5	0.4
Number of children fathered	0.4	0.5	1.5	-0.5	-0.6	-0.3	-1.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.1	1.1	0.3	-1.0	0.4	-0.6
Age at first live birth	0.7	1.3	4.3	-0.7	-0.3	2.1	-0.2	1.3
Pulse wave peak to peak time	0.2	0.2	0.6	0.4	0.1	-0.8	0.2	-0.5
Health satisfaction	2.3	3.0	9.1	3.0	0.5	-1.9	-0.6	-1.3
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.1	-0.2
Qualifications: College or University degree	0.2	0.6	2.2	-0.1	1.5	0.7	0.1	0.4
Eye problems/disorders: None of the above	0.5	0.5	1.0	0.6	-0.5	0.8	0.7	1.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.3	-0.4	-0.2	0.0	-0.0
Emphysema/chronic bronchitis	0.6	0.6	1.4	-0.6	0.6	0.7	-1.2	0.7
Medication for pain relief, constipation, heartburn	1.0	1.7	3.1	-1.5	0.1	1.3	1.1	1.8
Neck or shoulder pain in last month	0.4	0.6	1.6	-0.1	-0.7	-0.8	-0.4	-1.3
Medication: Blood pressure	1.2	2.1	3.2	1.2	-0.6	-1.6	-1.8	-1.8
Angina (self-reported)	0.3	0.4	0.8	0.5	0.3	-0.9	-0.5	-0.8
Migraine (self-reported)	0.6	0.7	1.6	0.9	0.6	-1.3	0.4	-0.7
Medication: Ibuprofen	0.1	0.1	0.2	-0.1	0.1	0.1	-0.2	-0.5
Medication: Allopurinol	0.5	0.7	1.4	1.0	1.2	-0.9	-0.6	-0.3
Medication: Omeprazole	0.5	0.6	1.5	1.2	0.3	-0.6	-0.8	-0.8
Medication: Seretide 50 evohaler	0.7	0.8	2.1	-0.6	1.5	1.0	-0.3	0.7
Mean time to correctly identify matches	2.5	4.7	8.5	1.6	-2.1	-2.2	-1.8	-2.9
Heart disease (mother)	0.6	0.7	2.4	0.7	-0.4	-1.5	-0.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.8	-0.7	0.5	1.2	1.2	1.7
Whole body fat mass	0.2	1.0	2.4	-1.6	-0.4	0.0	-1.3	-0.8
Leg fat mass (right)	0.3	1.2	2.2	-1.0	-0.4	-0.8	-1.4	-1.5
Arm predicted mass (right)	0.2	1.3	2.9	-0.3	1.3	-0.1	1.7	1.3
Pulse rate, automated reading	1.4	4.5	14.8	1.0	0.4	-1.3	-3.9	-2.2
Alcohol intake frequency.	1.3	2.9	4.3	-1.9	2.1	1.5	1.1	1.8
Comparative height size at age 10	2.9	15.8	23.8	-3.4	3.9	4.9	3.1	4.4
Number of full sisters	0.6	0.8	2.6	0.4	-0.6	-0.8	1.6	-0.2
Suffer from ‘nerves’	1.0	1.6	3.1	0.8	1.8	0.8	0.9	1.8
Overall health rating	1.1	2.4	6.3	1.2	-0.0	-1.6	-2.5	-1.3
Chest pain or discomfort	0.2	0.3	1.0	0.3	1.0	-0.6	-0.1	-0.5
Had major operations	0.2	0.3	0.7	0.2	0.7	0.3	0.8	0.3
Age at last live birth	1.7	2.5	5.8	-1.9	0.6	2.4	0.4	1.6
Family relationship satisfaction	0.1	0.2	0.3	0.4	-0.2	-0.6	-0.4	-0.4
Leg pain on walking	1.4	1.7	5.9	0.8	-0.0	-1.2	-2.4	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	0.2	0.7	-0.4	0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.1	0.6	1.0	-0.9	0.6	-0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.9	0.2	-1.1	0.4	-1.7	0.1
Medication: Aspirin	2.8	3.7	6.4	1.4	-1.7	-2.2	-1.6	-2.5
Supplements: Vitamin C	0.2	0.3	0.6	-0.8	0.3	0.2	0.2	-0.7
Knee pain experienced in last month	0.3	0.4	0.7	-0.4	-0.7	-0.9	-0.8	0.1
Hypertension (Self-reported)	0.2	0.4	2.0	0.0	0.0	0.1	-1.4	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.3	0.3	-0.1	-0.1	0.4
Illnesses of father: Heart disease	0.5	0.8	1.6	0.4	0.7	-1.2	-0.6	-1.1
Illnesses of siblings: Diabetes	0.5	0.6	1.1	-0.4	0.5	-0.8	-1.1	-0.8
Smoking status: Previous	0.1	0.2	0.5	0.3	-0.1	-0.7	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.9	-1.4	0.1	0.8	0.7	0.3
Whole body fat-free mass	0.5	2.9	4.5	-1.2	1.7	1.0	2.1	2.1
Leg fat-free mass (right)	0.7	3.8	6.2	-1.6	2.2	1.6	1.6	2.5
Arm fat percentage (left)	0.5	1.8	4.8	-1.8	-0.5	0.3	-2.2	-0.9
Average weekly red wine intake	0.5	0.8	2.8	0.4	0.3	0.0	1.7	1.0
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.4	-0.7	1.2	0.5	1.0	1.1
Mood swings	0.5	0.8	2.3	-1.5	0.7	1.1	-0.1	0.4
Loneliness, isolation	0.2	0.3	0.6	-0.2	0.6	-0.4	-0.7	-0.5
Long-standing illness, disability or infirmity	0.2	0.3	1.0	0.5	0.4	-0.3	-1.0	-0.1
Ever had bowel cancer screening	0.2	0.3	0.7	0.1	0.4	-0.2	0.7	0.9
Diabetes diagnosed by doctor	0.7	1.1	4.0	0.0	-0.5	-1.2	-0.0	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.1	0.7	1.4	0.4	0.2	0.3
Friendships satisfaction	0.4	0.5	1.2	0.9	1.1	-0.7	-0.3	-0.3
Qualifications: nursing, teaching	0.9	1.3	3.0	-0.2	1.1	1.7	0.3	1.5
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.5	-0.7	0.2	0.4	0.0
Eye problems/disorders: Cataract	0.4	0.4	1.2	0.3	0.3	-0.8	0.4	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	5.7	1.1	-2.4	-1.5	0.1	-1.5
Medication for cholesterol	0.2	0.3	0.9	0.9	-0.5	-0.3	-0.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	1.3	-0.1	-0.6	1.1	-0.5
Back pain experienced in last month	1.9	2.8	4.2	2.0	-0.3	-2.0	-1.7	-1.8
Mineral and other dietary supplements	1.3	1.8	4.8	0.0	-1.9	0.3	-2.2	-0.7
Breast cancer (self-reported)	0.5	0.6	1.4	-0.4	1.2	0.9	0.2	0.5
Asthma (self-reported)	0.1	0.2	0.6	0.8	0.1	-0.2	-0.0	-0.5
Osteoporosis (self-reported)	0.9	1.1	2.7	-0.3	1.3	0.6	-1.6	1.0
Osteoarthritis (self-reported)	0.8	1.0	1.8	-0.9	1.1	1.1	-0.3	1.3
Medication: Aspirin	3.6	4.7	6.5	1.7	-1.6	-2.4	-2.3	-2.5
Medication: Gliclazide	0.1	0.1	0.4	0.6	0.4	-0.1	-0.3	0.1
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	0.2	-0.9	0.1	0.9	-0.1
Smoking status: Current	0.2	0.4	1.0	-0.5	0.2	1.0	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	1.5	1.1	-1.1	0.1	0.7
Whole body water mass	0.5	2.9	4.6	-1.2	1.7	1.0	2.1	2.1
Leg predicted mass (right)	0.7	3.9	6.5	-1.6	2.3	1.7	1.6	2.5
Arm fat mass (left)	0.2	0.8	3.0	-1.7	0.0	0.4	-1.0	-0.2
Number of self-reported non-cancer illnesses	0.5	0.8	2.8	0.8	0.8	-0.2	-1.7	0.2
Average weekly champagne plus white wine intake	0.7	1.0	3.3	1.8	0.1	-0.9	-0.7	-0.7
Miserableness	0.1	0.2	0.9	-0.2	1.0	0.1	-0.4	-0.0
Guilty feelings	1.0	1.5	2.4	-1.2	0.3	1.5	1.2	1.4
Wears glasses or contact lenses	2.4	2.8	5.6	-2.4	1.2	1.9	-0.5	1.7
Ever taken oral contraceptive pill	0.6	0.7	1.2	0.8	0.8	-1.1	0.6	-0.7
Hearing aid user	0.2	0.2	0.5	0.7	-0.7	-0.1	-0.1	-0.2
Mother’s age at death	0.6	0.7	2.1	-0.9	0.6	1.4	-0.6	0.3
Financial situation satisfaction	0.4	0.5	2.0	1.4	0.3	-0.5	-0.3	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.7	0.3	0.4	0.7	0.6	1.3
Commuting to job workplace: Public transport	1.9	2.3	5.0	-1.8	0.2	2.2	-1.1	1.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	-1.0	1.1	0.4	1.0	0.5
Medication: Blood pressure	0.3	0.6	1.3	-1.2	0.6	0.9	0.2	0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.7	-1.3	0.4	0.1	-0.8	0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	4.3	-0.5	0.8	-0.3	2.1	0.1
High cholesterol (Self-reported)	0.2	0.4	1.4	-1.2	-0.0	0.5	-0.7	-0.2
Medication: Bendroflumethiazide	1.0	1.6	4.9	-0.8	0.3	1.5	-2.2	0.3
Medication: Paracetamol	0.0	0.1	0.2	-0.2	0.4	-0.1	-0.3	0.0
Medication: Lisinopril	0.9	1.2	2.5	0.5	-1.0	-0.2	-1.6	-1.4
Medication: Atorvastatin	0.9	1.1	1.9	1.0	0.0	-1.3	1.4	-1.0
Illnesses of father: High blood pressure	0.2	0.3	0.9	-1.0	-0.3	0.5	0.3	-0.1
Alcohol drinker status: Never	1.4	1.6	3.1	0.4	-1.5	-1.8	0.4	-1.6
Ever smoked	0.1	0.2	0.4	-0.1	0.6	-0.1	0.6	0.1
Basal metabolic rate	0.4	2.0	3.1	-1.3	1.4	0.8	1.6	1.8
Leg fat percentage (left)	0.8	3.0	5.1	-0.8	-1.7	-1.4	-2.2	-2.2
Arm fat-free mass (left)	0.2	1.2	3.6	-0.5	0.8	-0.0	1.9	1.2
Number of operations (self-reported)	0.6	0.9	2.5	0.6	0.3	-1.1	1.6	-0.4
Average weekly beer plus cider intake	1.0	1.4	3.7	1.2	0.4	-1.9	0.6	-1.2
Irritability	0.6	1.0	2.6	-0.0	-0.7	-0.7	-1.6	-1.2
Risk taking	1.0	1.4	5.2	0.4	-2.3	-0.4	-0.4	-1.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	-0.0	0.5	0.2	-1.0	0.3
Fractured/broken bones in last 5 years	2.2	2.9	9.0	-1.3	-3.0	-0.6	1.4	-1.2
Age started oral contraceptive pill	0.5	0.6	1.1	-0.8	0.2	1.0	0.5	1.0
Diastolic blood pressure, automated reading	0.9	2.9	11.9	-0.4	1.5	0.4	-3.5	0.5
Ever depressed for a whole week	0.9	1.2	2.1	-0.9	1.2	1.0	0.7	1.4
Unable to work because of sickness or disability	1.3	1.6	3.3	-0.4	1.1	-1.3	-1.3	-1.8
Commuting to job workplace: Cycle	1.1	1.3	2.8	-1.2	-0.4	1.5	-0.1	1.7
Myopia	3.5	5.1	8.8	-2.1	1.3	3.0	1.8	2.6
Vascular/heart problems diagnosed by doctor	0.6	1.6	6.2	-0.2	0.2	0.5	2.5	1.2
Cholesterol lowering medication	0.4	0.6	1.0	0.3	-1.0	-0.9	0.3	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.9	0.7	-0.5	0.1	-0.5
Pain experienced in last month	1.1	1.8	5.2	-1.2	0.5	2.3	0.1	1.5
Supplements: Calcium	0.7	0.7	1.7	-0.3	1.3	1.0	-0.0	0.9
Basal cell carcinoma (self-reported)	1.4	1.7	3.7	1.7	-0.3	-1.9	1.1	-0.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.6	-0.2	-0.7	-1.0	-2.1	-1.8
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	5.6	2.0	-1.3	-1.9	-1.7	-2.4
Heart disease (siblings)	0.7	0.8	2.0	0.0	-0.7	-0.8	-0.9	-1.4
Alcohol drinker status: Previous	0.6	0.7	1.5	0.2	-0.8	-0.4	-1.2	-1.0
Pack years of smoking	1.3	1.9	4.6	0.1	-1.4	-1.2	-1.1	-2.1
Impedance of whole body	0.3	1.3	4.3	0.8	-1.1	-0.5	-0.3	-2.1
Leg fat mass (left)	0.3	1.0	1.7	-0.9	-0.5	-0.8	-1.3	-1.3
Arm predicted mass (left)	0.3	1.5	3.3	-0.5	1.2	0.3	1.8	1.6