Hub : Genes

CSTF3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0769 0.0408 9.5e-03 0.061 NA 0.062 NA 0.086 4.0e-05 NA 3.3e-05 NA 1.2e-06
2 METSIM Adipose 0.0613 0.0199 4.2e-06 0.009 0.041 0.029 0.039 0.024 1.6e-02 8.9e-07 3.3e-05 1.5e-06 1.2e-04
3 NTR Blood 0.0469 0.0140 6.8e-14 0.053 0.046 0.046 0.048 0.051 1.3e-16 1.1e-14 1.6e-14 3.6e-15 4.6e-16
4 YFS Blood 0.1328 0.0323 1.9e-12 0.018 0.049 0.072 0.076 0.037 9.3e-07 1.5e-15 1.2e-22 1.3e-23 3.8e-12
5 TCGA Thyroid Carcinoma 0.0330 0.0190 6.4e-04 0.024 0.035 0.025 NA 0.022 2.1e-03 2.4e-04 1.5e-03 NA 2.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.5 1.3 -0.4 0.4 0.1 -1.0 -1.2
Bipolar Disorder or Schizophrenia 0.4 1.0 2.5 -0.3 1.6 0.0 -1.5 -0.2
Depressed Affect (Nagel 2018) 0.1 0.3 0.9 -1.0 0.6 0.1 -0.4 -0.2
Depression (Nagel 2018) 2.1 3.2 5.1 1.7 0.3 -2.3 -2.0 -1.9
Intelligence (Savage-Jansen 2018) 1.0 3.1 6.2 -0.8 2.1 2.5 -0.2 2.0
Neuroticism (Nagel 2018) 0.4 0.9 2.7 -0.9 1.7 0.8 0.1 0.7
Schizophrenia (2018) 0.4 0.9 2.9 -0.1 1.7 -0.0 -1.1 0.6
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 -0.5 -0.3 0.6 -0.1 0.7
Worry (Nagel 2018) 0.2 0.5 1.8 0.2 1.3 0.1 -0.1 0.8
Alzheimer’s Disease (in mother) 0.7 0.8 1.6 1.2 1.3 -0.6 -0.7 0.4
Alzheimer’s Disease (in father) 0.3 0.4 0.9 0.5 -0.7 -0.9 -0.1 -0.4
Alzheimer’s Disease (including proxy) 0.7 1.0 2.3 1.4 0.5 -1.5 -0.5 -0.4
Crohns Disease (2017) 0.5 1.2 2.7 0.0 -0.9 -1.6 1.0 -1.2
Irritable Bowel Disease (IBD) 0.5 1.3 2.9 1.1 -0.6 -1.7 -0.7 -1.3
Ulcerative Colitis (UC) 0.9 1.6 3.5 1.4 -0.3 -1.2 -1.9 -1.0
Major Depression (MDD) 0.1 0.2 0.4 -0.0 -0.4 0.4 -0.6 0.3
Reaction Time 4.0 7.6 14.1 2.3 -2.4 -2.8 -2.2 -3.7
Verbal and Numeric Reasoning (VNR) 0.8 1.9 6.9 -0.1 2.6 0.8 -1.3 0.2
Breast Cancer 1.3 3.2 4.7 -1.1 2.2 1.8 1.8 2.0
Ovarian Cancer 1.6 2.2 3.9 -0.7 1.9 1.6 0.4 2.0
Prostate Cancer 0.9 1.2 2.9 -1.2 1.7 0.7 0.5 0.9
Age at First Birth 0.5 0.7 1.1 -0.7 0.8 1.1 0.1 1.1
Bipolar Disorder (2011) 0.7 0.7 1.7 -1.1 1.3 0.4 -0.4 -0.3
Body Mass Index (BMI) (2010) 1.1 1.6 3.2 -1.5 0.0 1.4 -1.8 0.6
Coronary Artery Disease (CAD) 2.1 2.5 5.1 0.7 -1.4 -2.3 -0.7 -2.1
Crohns Disease (2012) 0.2 0.3 0.7 -0.4 -0.2 -0.9 0.3 -0.7
Mean Putamen Volume 1.2 1.3 2.9 -0.4 -0.4 1.0 1.6 1.7
Fasting Glucose 0.2 0.3 0.5 -0.6 0.2 -0.5 0.5 -0.7
HbA1C 0.1 0.2 0.4 -0.5 0.2 0.2 0.0 0.7
HDL Cholesterol 1.1 1.9 2.8 -0.6 1.7 1.5 1.4 1.4
LDL Cholesterol 0.2 0.3 0.6 0.4 0.7 -0.8 0.2 -0.5
Lupus 2.1 3.2 5.5 1.5 -2.3 -1.5 -1.0 -2.2
Neuroticism (2016) 1.0 1.4 6.0 0.7 2.4 -0.2 0.5 0.6
Primary Biliary Cirrhosis 0.4 0.5 1.4 0.9 1.2 0.1 -0.6 -0.1
Rheumatoid Arthritis 0.4 0.6 1.2 -1.1 -0.2 -0.1 -0.9 -0.9
Schizophrenia (2014) 0.3 0.6 1.5 0.2 1.1 -0.2 -1.2 0.2
Triglycerides 0.1 0.1 0.2 0.4 -0.4 -0.1 0.2 -0.1
Type 2 Diabetes (T2D) (2012) 2.8 3.3 7.7 -1.1 -0.9 -1.5 -2.0 -2.8
Ulcerative Colitis 3.2 4.6 9.1 2.0 -0.9 -2.1 -3.0 -2.2
Blood Eosinophil Count 0.4 2.9 12.0 -0.8 -0.2 1.2 -3.5 -0.4
Blood Platelet Count 0.3 3.3 4.9 -0.7 2.2 1.3 2.2 2.2
Blood Red Count 0.1 1.1 3.5 1.9 0.3 -1.0 -0.7 0.6
Blood White Count 0.3 2.6 5.6 0.6 -1.1 -1.6 -1.7 -2.4
Heel T-Score 1.2 9.3 19.6 2.4 -3.3 -4.4 -0.4 -3.1
BMI 0.7 4.2 13.6 -0.7 -1.2 -0.8 -3.7 -2.1
Height 0.9 17.3 40.8 -2.0 3.3 3.8 6.4 4.1
Waist Hip Ratio (WHR) 0.7 3.3 6.0 2.5 0.4 -2.1 -0.6 -2.3
Systolic Blood Pressure 0.2 1.0 4.2 -0.1 -0.3 -0.4 -2.0 -0.6
Smoking Status 0.1 0.1 0.4 0.3 0.2 0.4 -0.7 0.1
Allergy or Eczema 0.2 0.4 1.5 0.4 0.5 -1.2 -0.3 -0.5
Cardiovascular Disease 0.9 2.9 9.4 0.7 -0.9 -1.1 -3.1 -1.6
Hypothyroidism (self reported) 0.8 1.9 6.0 0.8 -2.5 -1.0 0.2 -1.5
Respiratory disease 0.0 0.1 0.2 0.2 0.3 0.2 -0.5 -0.1
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.5 0.1 -1.2 -1.1 -0.2 -1.6
Lung FEV1/FVC ratio 0.2 1.3 3.5 1.7 -0.0 -0.2 -1.9 0.1
Lung FVC 0.8 4.1 11.2 1.6 3.4 -0.4 1.8 1.8
Neuroticism 0.2 0.5 1.9 -0.1 1.4 0.4 0.2 0.7
Chronotype (morning person) 1.5 3.4 5.1 -2.0 -2.2 -0.4 -1.7 -2.2
Hair Pigment 0.0 0.3 0.6 0.3 0.6 -0.8 0.1 -0.6
Tanning 0.1 1.0 3.5 0.7 -1.9 -0.7 0.2 -0.8
Hand grip strength (left) 0.6 1.6 4.9 1.2 0.8 -0.6 2.2 0.9
Number of treatments/medications taken 0.9 1.7 3.1 0.6 0.5 -1.7 -1.8 -1.4
Average weekly spirits intake 0.7 0.9 1.6 0.7 0.6 -0.5 1.3 -1.2
Sensitivity / hurt feelings 1.4 2.4 5.0 -0.9 2.2 1.7 0.9 1.6
Frequency of depressed mood in last 2 weeks 0.9 1.2 2.4 1.0 0.5 -1.2 -1.6 -1.1
Hearing difficulty/problems: Yes 0.5 0.7 1.5 -1.2 0.1 1.1 0.2 0.9
Relative age of first facial hair 4.9 10.0 14.0 2.8 -3.0 -3.7 -2.5 -3.6
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 1.7 1.2 1.1 0.6 -1.3 1.2
Ever used hormone-replacement therapy (HRT) 1.2 1.6 5.0 0.5 1.5 0.1 2.2 0.7
Ever had hysterectomy (womb removed) 1.5 1.7 2.8 -1.2 0.9 1.4 1.2 1.7
Systolic blood pressure, automated reading 0.5 1.4 5.3 -1.0 0.0 0.5 -2.3 0.4
Eye problems/disorders: Diabetes related eye disease 4.2 4.6 7.6 2.3 -1.8 -2.8 -0.5 -2.6
Angina 0.4 0.5 1.1 0.5 -0.0 -1.0 -0.4 -0.9
Medication for hormone replacement therapy 0.2 0.2 0.4 -0.6 0.1 0.0 0.6 -0.4
Vitamin and mineral supplements 1.0 1.4 4.3 0.4 0.7 1.2 0.8 2.1
Supplements: Zinc 1.3 1.4 5.5 -1.1 -0.1 0.5 2.3 0.0
Medication: Co-codamol 0.3 0.4 1.4 0.2 1.2 0.0 -0.6 0.4
Medication: Metformin 0.2 0.3 0.6 -0.8 -0.2 -0.2 -0.6 -0.7
Diabetes (father) 0.6 0.8 2.9 -1.7 0.3 0.8 -0.5 0.1
Diabetes (mother) 1.5 1.9 5.4 0.8 -0.7 -2.3 -0.9 -1.4
Severe depression (siblings) 1.4 1.6 3.5 -1.9 -0.1 1.3 0.8 1.4
Pack years adult smoking proportion 1.6 2.4 5.8 0.2 -1.5 -1.5 -1.3 -2.4
Impedance of leg (right) 1.0 4.7 11.3 1.6 -2.5 -1.9 -0.2 -3.4
Leg fat-free mass (left) 0.5 2.8 4.0 -1.8 1.8 1.4 1.3 2.0
Trunk fat percentage 0.5 2.1 5.2 -1.5 -1.0 -0.0 -2.3 -1.4
Hand grip strength (right) 0.5 1.5 3.3 1.0 0.6 -0.0 1.8 1.6
Townsend deprivation index at recruitment 0.1 0.2 0.3 0.2 0.5 -0.2 0.6 0.5
Current tobacco smoking 0.2 0.4 0.9 -0.4 -0.7 0.4 -0.9 -0.2
Average weekly fortified wine intake 0.8 0.9 2.2 1.0 0.0 -0.3 1.5 1.0
Maternal smoking around birth 1.2 1.7 3.7 1.2 0.0 -1.5 -1.9 -1.1
Fed-up feelings 0.1 0.2 0.5 -0.1 0.7 0.4 0.4 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 4.0 1.6 0.8 -1.9 -2.0 -0.9
Relative age voice broke 4.4 6.7 10.2 1.3 -2.6 -2.9 -2.6 -3.2
Taking other prescription medications 0.3 0.5 0.9 0.5 0.2 -0.8 -0.9 -1.0
Age when periods started (menarche) 0.8 2.0 3.8 2.0 -0.8 -1.3 1.5 -1.2
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 5.6 -0.6 -0.2 0.8 2.4 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 3.2 1.3 -1.8 -1.6 -0.7 -1.1
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 2.6 -1.2 1.6 0.9 1.1 1.1
Qualifications: CSEs or equivalent 1.8 2.4 4.7 -0.4 2.2 1.1 1.7 1.7
Serious illness, injury or assault to yourself 0.2 0.3 0.8 -0.3 0.9 0.4 0.1 0.6
High blood pressure 0.3 1.0 4.2 -0.0 -0.2 -0.2 -2.1 -0.7
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.8 0.2 0.6 -0.9 0.7 0.0
Multivitamins +/- minerals 1.0 1.3 3.0 -0.2 -1.1 -1.1 -1.1 -1.7
Stomach or abdominal pain in last month 0.6 0.7 1.3 1.1 0.9 -1.0 0.8 0.3
Supplements: Glucosamine 0.4 0.6 1.6 0.2 1.3 -0.3 0.2 1.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 1.9 1.4 -0.2 -1.3 1.2 -0.5
Medication: Atenolol 0.4 0.5 1.2 0.5 0.0 -1.1 -0.7 -0.9
Medication: Levothyroxine sodium 1.7 2.9 6.9 1.4 -2.6 -1.3 -1.3 -1.5
Sitting height 0.3 2.1 9.1 -0.3 1.1 -0.4 3.0 0.1
Chronic bronchitis/emphysema (father) 0.3 0.4 0.8 0.9 0.9 -0.0 -0.3 0.4
High blood pressure (mother) 1.7 2.3 4.7 1.6 -1.7 -0.9 -2.2 -0.7
Body mass index (BMI) 0.3 1.1 3.0 -1.4 -0.3 -0.1 -1.7 -0.4
Impedance of leg (left) 1.2 5.7 11.2 2.4 -2.5 -2.3 0.0 -3.3
Leg predicted mass (left) 0.5 2.8 3.9 -1.8 1.8 1.4 1.2 2.0
Trunk fat mass 0.2 1.1 2.8 -1.7 -0.3 0.2 -1.4 -0.6
Waist circumference 0.1 0.5 1.1 -0.9 0.4 -0.3 -1.0 -0.5
Number of incorrect matches in round 1.8 3.0 5.4 -2.3 -2.3 0.9 -1.6 -1.1
Past tobacco smoking 0.2 0.4 1.1 -0.5 -0.5 0.5 -1.0 -0.2
Alcohol usually taken with meals 1.0 1.6 3.2 -1.4 0.9 1.8 -0.9 1.1
Nervous feelings 1.0 1.9 2.4 -1.6 1.5 1.0 -1.4 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.2 0.6 -0.3 -1.5 -1.3 -1.4
Hearing difficulty/problems with background noise 1.4 2.2 4.1 -1.9 1.4 2.0 -0.3 1.1
Hair/balding pattern: Pattern 2 0.3 0.3 1.5 0.1 1.2 -0.1 0.3 0.3
Had menopause 2.2 2.7 4.1 -0.9 1.5 1.7 1.9 2.0
Had other major operations 1.5 1.9 8.5 -0.4 0.4 0.1 2.9 0.8
Forced vital capacity (FVC) 1.5 5.8 11.7 1.0 3.0 0.6 3.4 2.7
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 6.2 1.8 -2.5 -1.7 -0.4 -1.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.3 -0.1 1.1 0.5 0.3 0.6
Qualifications: None of the above 0.7 1.6 5.8 -1.4 -2.4 -0.3 0.2 -0.1
Financial difficulties in last 2 years 0.3 0.3 1.4 0.2 1.2 -0.5 -0.1 -0.0
Mouth/teeth dental problems 0.3 0.4 0.9 0.9 0.9 0.1 0.4 0.5
Heart attack 1.3 1.6 4.4 -0.4 -0.7 -0.8 -2.1 -1.6
Allergy 0.5 1.2 2.8 -1.0 0.5 1.7 0.6 1.3
Pain all over the body in last month 1.2 1.2 5.1 0.6 -0.2 -0.9 2.3 -0.3
Diabetes (self-reported) 0.5 0.8 2.8 -0.4 -0.3 -0.7 -0.6 -1.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.0 1.7 0.3 -1.3 0.8 0.1
Medication: Ramipril 1.0 1.3 2.7 1.6 0.6 -1.6 0.0 -1.1
Medication: Simvastatin 1.2 1.7 4.0 0.2 -0.8 -1.3 -2.0 -1.5
Fluid intelligence score 0.4 0.9 1.8 -0.5 1.0 1.3 0.0 1.2
Illnesses of siblings 1.2 1.7 3.4 0.1 0.0 1.3 1.8 1.8
Neuroticism score 0.1 0.3 1.1 -0.0 1.0 0.3 -0.0 0.5
Weight 0.2 0.8 2.3 -1.5 0.9 0.7 0.2 0.8
Impedance of arm (right) 0.1 0.4 1.8 -0.5 0.1 1.3 -0.0 -0.4
Arm fat percentage (right) 0.5 1.9 4.7 -1.9 -0.6 0.2 -2.2 -1.0
Trunk fat-free mass 0.4 2.6 5.7 -0.8 1.3 0.7 2.4 2.0
Hip circumference 0.3 1.2 3.4 -1.8 0.6 1.1 -0.3 1.0
Time employed in main current job 0.7 0.9 2.0 0.3 1.0 1.1 0.0 1.4
Alcohol intake versus 10 years previously 1.8 2.6 8.5 -1.4 0.7 0.8 2.9 1.3
Father’s age at death 0.7 0.9 2.1 -0.7 -0.1 1.3 -0.5 1.4
Worrier / anxious feelings 1.1 2.1 5.2 0.1 1.9 1.0 1.0 2.3
Frequency of tiredness / lethargy in last 2 weeks 3.3 5.4 10.3 1.9 0.1 -3.2 -2.4 -2.7
Falls in the last year 0.1 0.1 0.3 -0.1 -0.5 -0.5 -0.0 -0.1
Hair/balding pattern: Pattern 3 0.2 0.3 1.0 0.2 -1.0 -0.4 -0.7 -0.2
Number of live births 0.9 1.3 3.0 0.4 -0.4 -1.7 -1.3 -1.1
Forced expiratory volume in 1-second (FEV1) 1.6 5.3 9.1 1.2 3.0 0.9 2.6 2.9
Pulse rate 0.6 1.1 1.7 1.1 0.6 -0.7 -1.3 -1.3
Happiness 0.1 0.1 0.2 -0.1 0.5 -0.3 -0.2 -0.2
Noisy workplace 1.6 2.0 4.5 -0.1 -2.1 -1.6 0.1 -1.7
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.6 -0.2 1.0 1.3 -0.9 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.4 -0.3 0.4 0.0 0.6 0.2
Mouth/teeth dental problems: Dentures 0.4 0.7 2.2 -1.5 0.3 0.9 -0.7 0.2
Asthma 0.1 0.2 0.3 0.5 -0.3 -0.0 -0.2 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 -0.3 0.4 0.5 -0.4 0.1
Medication: Cholesterol lowering 0.3 0.4 0.9 -0.5 -0.0 -0.5 -0.9 -0.9
Depression (self-reported) 0.1 0.2 0.3 -0.2 -0.6 -0.2 0.4 -0.5
Medication: Lansoprazole 0.5 0.5 1.3 0.1 -0.8 -1.1 0.1 -0.8
Prospective memory result 1.4 1.7 3.6 -0.9 -1.7 -0.1 1.9 -1.0
Lung cancer (father) 1.7 2.0 5.1 1.0 -0.2 -2.3 -0.8 -1.8
Illnesses of mother 0.9 1.2 5.1 -0.1 0.1 -0.4 2.2 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.8 8.2 1.2 2.9 0.1 2.2 2.2
Pulse wave Arterial Stiffness index 0.4 0.5 1.2 -0.7 0.1 1.1 0.2 0.9
Impedance of arm (left) 0.1 0.7 2.8 -0.6 0.4 1.7 -0.2 -0.0
Arm fat mass (right) 0.2 0.8 2.3 -1.5 -0.1 0.2 -1.2 -0.4
Trunk predicted mass 0.5 2.8 5.9 -0.9 1.4 0.8 2.4 2.1
Standing height 0.6 6.0 15.0 -0.4 2.3 1.8 3.9 2.6
Length of working week for main job 0.3 0.3 1.4 0.2 1.2 0.2 0.3 0.1
Exposure to tobacco smoke at home 1.1 1.2 4.1 -0.1 -1.3 -0.4 -2.0 -0.4
Breastfed as a baby 0.3 0.4 1.1 0.6 1.0 0.1 -0.1 0.6
Tense / ‘highly strung’ 1.2 2.0 3.0 1.5 -0.2 -1.7 -1.7 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.2 5.2 -1.1 2.3 1.1 0.8 1.6
Hair/balding pattern: Pattern 4 1.6 3.9 7.8 -2.7 0.8 2.8 0.3 1.8
Birth weight of first child 0.1 0.3 0.6 -0.6 -0.8 0.2 0.1 0.5
Peak expiratory flow (PEF) 1.6 3.8 8.4 0.9 2.8 1.1 1.1 2.9
Pulse wave reflection index 0.5 0.6 1.1 -0.3 -1.1 0.6 0.7 1.0
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 -0.1 -0.8 0.2 0.4 -0.0
Loud music exposure frequency 2.4 2.7 3.9 -1.6 1.3 2.0 1.5 1.7
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.3 -0.8 1.4 1.5 -0.2 0.8
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.9 0.4 -0.4 -1.4 -0.2 -0.6
Blood clot in the leg (DVT) 3.5 4.5 7.0 2.3 -1.3 -2.4 -1.7 -2.6
Medication: Paracetamol 0.1 0.1 0.2 0.3 0.5 -0.4 0.3 -0.3
Headache pain in last month 0.2 0.3 0.9 -0.5 1.0 0.2 0.7 0.0
Medication for cholesterol, blood pressure or diabetes 0.9 1.6 3.4 -0.0 0.4 1.1 1.9 1.8
Glaucoma (self-reported) 0.7 0.8 1.2 -0.7 1.0 0.5 1.1 1.0
Gout (self-reported) 1.0 1.4 2.7 1.2 -0.0 -1.6 -1.2 -1.3
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 2.0 1.1 -1.4 -1.1 -0.3 -1.1
Medication: Amlodipine 0.8 1.1 3.2 1.2 1.8 0.1 0.6 0.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.2 0.0 0.5 0.6 1.1 0.8
Birth weight 0.2 0.5 1.0 -0.4 0.0 0.7 1.0 1.0
Chronic bronchitis/emphysema (mother) 2.7 3.1 13.5 1.1 -0.3 -0.2 -3.7 -0.9
High blood pressure (siblings) 1.8 2.6 5.4 0.9 -0.7 -2.1 -1.4 -2.3
Forced vital capacity (FVC), Best measure 1.0 3.6 7.3 1.5 2.7 -0.2 2.4 1.7
Body fat percentage 0.6 2.4 5.7 -1.4 -1.2 -0.3 -2.4 -1.7
Leg fat percentage (right) 1.0 3.7 6.5 -1.0 -1.7 -1.3 -2.5 -2.5
Arm fat-free mass (right) 0.3 1.5 3.5 -0.3 1.4 0.0 1.9 1.4
Exposure to tobacco smoke outside home 1.8 2.4 4.3 1.5 -1.9 -2.1 -0.5 -1.2
Comparative body size at age 10 0.8 2.1 4.1 -2.0 -0.5 1.8 -0.7 1.5
Number of full brothers 0.5 0.6 2.5 -0.6 0.2 -0.3 -1.6 -0.4
Worry too long after embarrassment 0.7 1.1 2.2 0.5 1.5 1.2 -0.1 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.5 -0.7 0.1 0.1 -0.4 0.1
Wheeze or whistling in the chest in last year 0.4 0.7 2.7 -0.1 1.6 0.5 0.5 0.4
Number of children fathered 0.4 0.5 1.5 -0.5 -0.6 -0.3 -1.2 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.1 1.1 0.3 -1.0 0.4 -0.6
Age at first live birth 0.7 1.3 4.3 -0.7 -0.3 2.1 -0.2 1.3
Pulse wave peak to peak time 0.2 0.2 0.6 0.4 0.1 -0.8 0.2 -0.5
Health satisfaction 2.3 3.0 9.1 3.0 0.5 -1.9 -0.6 -1.3
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.4 -0.4 -0.2 0.1 -0.2
Qualifications: College or University degree 0.2 0.6 2.2 -0.1 1.5 0.7 0.1 0.4
Eye problems/disorders: None of the above 0.5 0.5 1.0 0.6 -0.5 0.8 0.7 1.0
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.1 0.3 -0.4 -0.2 0.0 -0.0
Emphysema/chronic bronchitis 0.6 0.6 1.4 -0.6 0.6 0.7 -1.2 0.7
Medication for pain relief, constipation, heartburn 1.0 1.7 3.1 -1.5 0.1 1.3 1.1 1.8
Neck or shoulder pain in last month 0.4 0.6 1.6 -0.1 -0.7 -0.8 -0.4 -1.3
Medication: Blood pressure 1.2 2.1 3.2 1.2 -0.6 -1.6 -1.8 -1.8
Angina (self-reported) 0.3 0.4 0.8 0.5 0.3 -0.9 -0.5 -0.8
Migraine (self-reported) 0.6 0.7 1.6 0.9 0.6 -1.3 0.4 -0.7
Medication: Ibuprofen 0.1 0.1 0.2 -0.1 0.1 0.1 -0.2 -0.5
Medication: Allopurinol 0.5 0.7 1.4 1.0 1.2 -0.9 -0.6 -0.3
Medication: Omeprazole 0.5 0.6 1.5 1.2 0.3 -0.6 -0.8 -0.8
Medication: Seretide 50 evohaler 0.7 0.8 2.1 -0.6 1.5 1.0 -0.3 0.7
Mean time to correctly identify matches 2.5 4.7 8.5 1.6 -2.1 -2.2 -1.8 -2.9
Heart disease (mother) 0.6 0.7 2.4 0.7 -0.4 -1.5 -0.7 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.8 -0.7 0.5 1.2 1.2 1.7
Whole body fat mass 0.2 1.0 2.4 -1.6 -0.4 0.0 -1.3 -0.8
Leg fat mass (right) 0.3 1.2 2.2 -1.0 -0.4 -0.8 -1.4 -1.5
Arm predicted mass (right) 0.2 1.3 2.9 -0.3 1.3 -0.1 1.7 1.3
Pulse rate, automated reading 1.4 4.5 14.8 1.0 0.4 -1.3 -3.9 -2.2
Alcohol intake frequency. 1.3 2.9 4.3 -1.9 2.1 1.5 1.1 1.8
Comparative height size at age 10 2.9 15.8 23.8 -3.4 3.9 4.9 3.1 4.4
Number of full sisters 0.6 0.8 2.6 0.4 -0.6 -0.8 1.6 -0.2
Suffer from ‘nerves’ 1.0 1.6 3.1 0.8 1.8 0.8 0.9 1.8
Overall health rating 1.1 2.4 6.3 1.2 -0.0 -1.6 -2.5 -1.3
Chest pain or discomfort 0.2 0.3 1.0 0.3 1.0 -0.6 -0.1 -0.5
Had major operations 0.2 0.3 0.7 0.2 0.7 0.3 0.8 0.3
Age at last live birth 1.7 2.5 5.8 -1.9 0.6 2.4 0.4 1.6
Family relationship satisfaction 0.1 0.2 0.3 0.4 -0.2 -0.6 -0.4 -0.4
Leg pain on walking 1.4 1.7 5.9 0.8 -0.0 -1.2 -2.4 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.5 0.2 0.7 -0.4 0.6 0.2
Commuting to job workplace: Car/motor vehicle 0.6 0.6 1.1 0.6 1.0 -0.9 0.6 -0.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.9 0.2 -1.1 0.4 -1.7 0.1
Medication: Aspirin 2.8 3.7 6.4 1.4 -1.7 -2.2 -1.6 -2.5
Supplements: Vitamin C 0.2 0.3 0.6 -0.8 0.3 0.2 0.2 -0.7
Knee pain experienced in last month 0.3 0.4 0.7 -0.4 -0.7 -0.9 -0.8 0.1
Hypertension (Self-reported) 0.2 0.4 2.0 0.0 0.0 0.1 -1.4 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.3 0.3 -0.1 -0.1 0.4
Illnesses of father: Heart disease 0.5 0.8 1.6 0.4 0.7 -1.2 -0.6 -1.1
Illnesses of siblings: Diabetes 0.5 0.6 1.1 -0.4 0.5 -0.8 -1.1 -0.8
Smoking status: Previous 0.1 0.2 0.5 0.3 -0.1 -0.7 0.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.9 -1.4 0.1 0.8 0.7 0.3
Whole body fat-free mass 0.5 2.9 4.5 -1.2 1.7 1.0 2.1 2.1
Leg fat-free mass (right) 0.7 3.8 6.2 -1.6 2.2 1.6 1.6 2.5
Arm fat percentage (left) 0.5 1.8 4.8 -1.8 -0.5 0.3 -2.2 -0.9
Average weekly red wine intake 0.5 0.8 2.8 0.4 0.3 0.0 1.7 1.0
Handedness (chirality/laterality): Left-handed 0.7 0.9 1.4 -0.7 1.2 0.5 1.0 1.1
Mood swings 0.5 0.8 2.3 -1.5 0.7 1.1 -0.1 0.4
Loneliness, isolation 0.2 0.3 0.6 -0.2 0.6 -0.4 -0.7 -0.5
Long-standing illness, disability or infirmity 0.2 0.3 1.0 0.5 0.4 -0.3 -1.0 -0.1
Ever had bowel cancer screening 0.2 0.3 0.7 0.1 0.4 -0.2 0.7 0.9
Diabetes diagnosed by doctor 0.7 1.1 4.0 0.0 -0.5 -1.2 -0.0 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 2.1 0.7 1.4 0.4 0.2 0.3
Friendships satisfaction 0.4 0.5 1.2 0.9 1.1 -0.7 -0.3 -0.3
Qualifications: nursing, teaching 0.9 1.3 3.0 -0.2 1.1 1.7 0.3 1.5
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.5 -0.7 0.2 0.4 0.0
Eye problems/disorders: Cataract 0.4 0.4 1.2 0.3 0.3 -0.8 0.4 -1.1
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 5.7 1.1 -2.4 -1.5 0.1 -1.5
Medication for cholesterol 0.2 0.3 0.9 0.9 -0.5 -0.3 -0.4 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.7 1.3 -0.1 -0.6 1.1 -0.5
Back pain experienced in last month 1.9 2.8 4.2 2.0 -0.3 -2.0 -1.7 -1.8
Mineral and other dietary supplements 1.3 1.8 4.8 0.0 -1.9 0.3 -2.2 -0.7
Breast cancer (self-reported) 0.5 0.6 1.4 -0.4 1.2 0.9 0.2 0.5
Asthma (self-reported) 0.1 0.2 0.6 0.8 0.1 -0.2 -0.0 -0.5
Osteoporosis (self-reported) 0.9 1.1 2.7 -0.3 1.3 0.6 -1.6 1.0
Osteoarthritis (self-reported) 0.8 1.0 1.8 -0.9 1.1 1.1 -0.3 1.3
Medication: Aspirin 3.6 4.7 6.5 1.7 -1.6 -2.4 -2.3 -2.5
Medication: Gliclazide 0.1 0.1 0.4 0.6 0.4 -0.1 -0.3 0.1
Illnesses of father: None of the above (group 1) 0.3 0.3 0.8 0.2 -0.9 0.1 0.9 -0.1
Smoking status: Current 0.2 0.4 1.0 -0.5 0.2 1.0 -0.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.2 1.5 1.1 -1.1 0.1 0.7
Whole body water mass 0.5 2.9 4.6 -1.2 1.7 1.0 2.1 2.1
Leg predicted mass (right) 0.7 3.9 6.5 -1.6 2.3 1.7 1.6 2.5
Arm fat mass (left) 0.2 0.8 3.0 -1.7 0.0 0.4 -1.0 -0.2
Number of self-reported non-cancer illnesses 0.5 0.8 2.8 0.8 0.8 -0.2 -1.7 0.2
Average weekly champagne plus white wine intake 0.7 1.0 3.3 1.8 0.1 -0.9 -0.7 -0.7
Miserableness 0.1 0.2 0.9 -0.2 1.0 0.1 -0.4 -0.0
Guilty feelings 1.0 1.5 2.4 -1.2 0.3 1.5 1.2 1.4
Wears glasses or contact lenses 2.4 2.8 5.6 -2.4 1.2 1.9 -0.5 1.7
Ever taken oral contraceptive pill 0.6 0.7 1.2 0.8 0.8 -1.1 0.6 -0.7
Hearing aid user 0.2 0.2 0.5 0.7 -0.7 -0.1 -0.1 -0.2
Mother’s age at death 0.6 0.7 2.1 -0.9 0.6 1.4 -0.6 0.3
Financial situation satisfaction 0.4 0.5 2.0 1.4 0.3 -0.5 -0.3 0.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.7 0.3 0.4 0.7 0.6 1.3
Commuting to job workplace: Public transport 1.9 2.3 5.0 -1.8 0.2 2.2 -1.1 1.4
Eye problems/disorders: Glaucoma 0.6 0.7 1.2 -1.0 1.1 0.4 1.0 0.5
Medication: Blood pressure 0.3 0.6 1.3 -1.2 0.6 0.9 0.2 0.8
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.7 -1.3 0.4 0.1 -0.8 0.3
Supplements: Fish oil (including cod liver oil) 0.8 1.0 4.3 -0.5 0.8 -0.3 2.1 0.1
High cholesterol (Self-reported) 0.2 0.4 1.4 -1.2 -0.0 0.5 -0.7 -0.2
Medication: Bendroflumethiazide 1.0 1.6 4.9 -0.8 0.3 1.5 -2.2 0.3
Medication: Paracetamol 0.0 0.1 0.2 -0.2 0.4 -0.1 -0.3 0.0
Medication: Lisinopril 0.9 1.2 2.5 0.5 -1.0 -0.2 -1.6 -1.4
Medication: Atorvastatin 0.9 1.1 1.9 1.0 0.0 -1.3 1.4 -1.0
Illnesses of father: High blood pressure 0.2 0.3 0.9 -1.0 -0.3 0.5 0.3 -0.1
Alcohol drinker status: Never 1.4 1.6 3.1 0.4 -1.5 -1.8 0.4 -1.6
Ever smoked 0.1 0.2 0.4 -0.1 0.6 -0.1 0.6 0.1
Basal metabolic rate 0.4 2.0 3.1 -1.3 1.4 0.8 1.6 1.8
Leg fat percentage (left) 0.8 3.0 5.1 -0.8 -1.7 -1.4 -2.2 -2.2
Arm fat-free mass (left) 0.2 1.2 3.6 -0.5 0.8 -0.0 1.9 1.2
Number of operations (self-reported) 0.6 0.9 2.5 0.6 0.3 -1.1 1.6 -0.4
Average weekly beer plus cider intake 1.0 1.4 3.7 1.2 0.4 -1.9 0.6 -1.2
Irritability 0.6 1.0 2.6 -0.0 -0.7 -0.7 -1.6 -1.2
Risk taking 1.0 1.4 5.2 0.4 -2.3 -0.4 -0.4 -1.2
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.9 -0.0 0.5 0.2 -1.0 0.3
Fractured/broken bones in last 5 years 2.2 2.9 9.0 -1.3 -3.0 -0.6 1.4 -1.2
Age started oral contraceptive pill 0.5 0.6 1.1 -0.8 0.2 1.0 0.5 1.0
Diastolic blood pressure, automated reading 0.9 2.9 11.9 -0.4 1.5 0.4 -3.5 0.5
Ever depressed for a whole week 0.9 1.2 2.1 -0.9 1.2 1.0 0.7 1.4
Unable to work because of sickness or disability 1.3 1.6 3.3 -0.4 1.1 -1.3 -1.3 -1.8
Commuting to job workplace: Cycle 1.1 1.3 2.8 -1.2 -0.4 1.5 -0.1 1.7
Myopia 3.5 5.1 8.8 -2.1 1.3 3.0 1.8 2.6
Vascular/heart problems diagnosed by doctor 0.6 1.6 6.2 -0.2 0.2 0.5 2.5 1.2
Cholesterol lowering medication 0.4 0.6 1.0 0.3 -1.0 -0.9 0.3 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 0.9 0.7 -0.5 0.1 -0.5
Pain experienced in last month 1.1 1.8 5.2 -1.2 0.5 2.3 0.1 1.5
Supplements: Calcium 0.7 0.7 1.7 -0.3 1.3 1.0 -0.0 0.9
Basal cell carcinoma (self-reported) 1.4 1.7 3.7 1.7 -0.3 -1.9 1.1 -0.7
Heart attack/myocardial infarction (self-reported) 1.4 1.8 4.6 -0.2 -0.7 -1.0 -2.1 -1.8
Deep venous thrombosis (DVT) (self-reported) 2.7 3.5 5.6 2.0 -1.3 -1.9 -1.7 -2.4
Heart disease (siblings) 0.7 0.8 2.0 0.0 -0.7 -0.8 -0.9 -1.4
Alcohol drinker status: Previous 0.6 0.7 1.5 0.2 -0.8 -0.4 -1.2 -1.0
Pack years of smoking 1.3 1.9 4.6 0.1 -1.4 -1.2 -1.1 -2.1
Impedance of whole body 0.3 1.3 4.3 0.8 -1.1 -0.5 -0.3 -2.1
Leg fat mass (left) 0.3 1.0 1.7 -0.9 -0.5 -0.8 -1.3 -1.3
Arm predicted mass (left) 0.3 1.5 3.3 -0.5 1.2 0.3 1.8 1.6