Hub : Genes

DCDC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.049 0.022 0.0013 0.027 0.019 0.001 0.018 0.014 0.00027 0.0018 0.26 0.0023 0.0063
2 TCGA Thyroid Carcinoma 0.045 0.030 0.0091 0.011 0.003 0.000 NA 0.001 0.02900 0.1500 0.28 NA 0.2800

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.2 0.4 0.4
Bipolar Disorder or Schizophrenia 0.5 1.3 2.0 -0.8 -1.4
Depressed Affect (Nagel 2018) 0.2 0.3 0.6 -0.8 -0.3
Depression (Nagel 2018) 0.4 0.6 0.9 -0.6 -1.0
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.4 0.6 0.2
Neuroticism (Nagel 2018) 0.2 0.5 0.8 0.9 0.5
Schizophrenia (2018) 1.6 3.3 4.8 -1.4 -2.2
Schizophrenia vs Biploar Disorder 1.1 1.5 2.5 -0.7 -1.6
Worry (Nagel 2018) 0.3 0.6 1.1 1.0 -0.4
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 -0.8 -0.2
Alzheimer’s Disease (in father) 0.8 0.9 1.8 -1.3 0.1
Alzheimer’s Disease (including proxy) 0.3 0.4 0.6 -0.8 0.3
Crohns Disease (2017) 0.3 0.6 0.7 -0.7 -0.9
Irritable Bowel Disease (IBD) 0.6 1.4 1.7 1.3 1.0
Ulcerative Colitis (UC) 2.0 3.7 4.1 2.0 1.8
Major Depression (MDD) 0.9 1.1 2.2 -0.3 -1.5
Reaction Time 1.1 2.2 4.2 0.3 -2.1
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.5 0.7 0.2
Breast Cancer 0.3 0.7 0.9 -0.8 -0.9
Ovarian Cancer 0.1 0.1 0.2 -0.4 0.2
Prostate Cancer 0.0 0.0 0.0 -0.1 0.1
Age at First Birth 0.4 0.6 1.0 1.0 0.5
Bipolar Disorder (2011) 1.2 1.1 1.3 0.9 1.2
Body Mass Index (BMI) (2010) 0.0 0.1 0.1 -0.3 0.0
Coronary Artery Disease (CAD) 0.1 0.1 0.3 0.1 0.5
Crohns Disease (2012) 0.1 0.1 0.1 -0.3 -0.4
Mean Putamen Volume 0.5 0.6 1.1 1.1 0.3
Fasting Glucose 1.2 1.5 1.7 1.1 1.3
HbA1C 0.6 0.7 1.0 0.6 1.0
HDL Cholesterol 0.2 0.4 0.6 -0.4 -0.8
LDL Cholesterol 0.7 1.1 2.0 0.4 1.4
Lupus 0.1 0.2 0.4 -0.6 0.2
Neuroticism (2016) 0.1 0.1 0.2 0.4 0.1
Primary Biliary Cirrhosis 0.7 1.1 1.1 1.0 1.0
Rheumatoid Arthritis 0.8 1.1 2.2 1.5 0.2
Schizophrenia (2014) 1.2 2.6 4.2 -1.0 -2.0
Triglycerides 0.1 0.1 0.3 -0.1 0.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.4 0.1
Ulcerative Colitis 2.2 3.1 3.7 1.9 1.6
Blood Eosinophil Count 0.2 1.8 3.0 -0.8 -1.7
Blood Platelet Count 0.0 0.0 0.0 -0.1 -0.1
Blood Red Count 1.4 14.0 22.7 2.3 4.8
Blood White Count 0.2 1.2 2.2 0.3 1.5
Heel T-Score 0.1 0.4 0.7 -0.3 -0.8
BMI 0.4 2.5 4.6 -2.1 -0.6
Height 1.3 25.6 31.4 -5.6 -4.5
Waist Hip Ratio (WHR) 0.0 0.1 0.1 -0.4 -0.3
Systolic Blood Pressure 2.2 10.9 17.0 -2.2 -4.1
Smoking Status 2.1 5.0 6.5 -1.9 -2.5
Allergy or Eczema 1.4 3.8 4.9 2.2 1.6
Cardiovascular Disease 0.7 2.1 2.9 -1.2 -1.7
Hypothyroidism (self reported) 1.0 2.3 3.5 -1.9 -1.0
Respiratory disease 1.0 2.3 3.4 1.1 1.8
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.6 -0.8 0.5
Lung FEV1/FVC ratio 1.2 6.0 6.7 -2.3 -2.6
Lung FVC 0.1 0.6 1.1 -1.1 -0.2
Neuroticism 0.1 0.2 0.4 0.6 -0.0
Chronotype (morning person) 0.2 0.4 0.5 0.7 0.5
Hair Pigment 0.1 2.4 2.9 1.7 1.4
Tanning 0.1 1.1 2.2 0.3 1.5
Hand grip strength (left) 0.4 1.1 2.1 -1.4 0.1
Number of treatments/medications taken 0.1 0.2 0.4 -0.6 0.0
Average weekly spirits intake 2.8 3.4 4.1 1.6 2.0
Sensitivity / hurt feelings 4.3 7.4 9.9 2.2 3.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.5 -0.3 -0.7
Hearing difficulty/problems: Yes 0.2 0.3 0.5 -0.2 0.7
Relative age of first facial hair 0.4 0.7 1.2 -0.5 -1.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.4 -0.6 -0.2
Ever used hormone-replacement therapy (HRT) 2.3 2.9 3.5 -1.9 -1.5
Ever had hysterectomy (womb removed) 0.1 0.1 0.1 -0.3 -0.1
Systolic blood pressure, automated reading 3.2 9.4 12.1 -2.6 -3.5
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.2 -0.4 0.4
Angina 0.1 0.1 0.2 -0.1 -0.4
Medication for hormone replacement therapy 1.2 1.3 1.7 -1.3 -1.0
Vitamin and mineral supplements 0.5 0.7 1.3 0.3 -1.1
Supplements: Zinc 0.8 0.8 1.7 -1.3 0.2
Medication: Co-codamol 7.4 8.5 8.9 -2.9 -3.0
Medication: Metformin 1.4 1.9 3.5 -1.9 -0.7
Diabetes (father) 0.8 1.0 1.7 0.5 1.3
Diabetes (mother) 0.8 1.1 1.4 -0.8 -1.2
Severe depression (siblings) 0.6 0.7 0.8 0.7 0.9
Pack years adult smoking proportion 3.2 4.9 6.8 -2.6 -1.7
Impedance of leg (right) 0.3 1.6 3.0 0.3 -1.7
Leg fat-free mass (left) 0.4 2.3 4.4 -2.1 -0.4
Trunk fat percentage 1.0 4.0 4.9 -2.2 -1.8
Hand grip strength (right) 0.6 1.6 3.0 -1.7 -0.4
Townsend deprivation index at recruitment 3.2 4.5 5.2 -2.0 -2.3
Current tobacco smoking 2.4 3.9 5.0 -1.7 -2.2
Average weekly fortified wine intake 0.6 0.7 0.7 0.9 0.9
Maternal smoking around birth 0.0 0.0 0.1 0.0 0.2
Fed-up feelings 1.0 1.8 2.7 -1.6 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 3.0 -1.4 -1.7
Relative age voice broke 0.1 0.1 0.1 0.4 -0.3
Taking other prescription medications 3.0 4.6 5.2 -2.3 -2.0
Age when periods started (menarche) 0.8 1.9 2.1 -1.3 -1.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.3 -0.6 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 1.7 1.3 0.7
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 0.7 -0.8 -0.6
Qualifications: CSEs or equivalent 0.1 0.1 0.3 -0.1 -0.5
Serious illness, injury or assault to yourself 1.4 1.7 2.4 -1.5 -1.0
High blood pressure 0.7 2.1 3.2 -0.9 -1.8
Hayfever, allergic rhinitis or eczema 1.3 2.8 3.0 1.7 1.6
Multivitamins +/- minerals 0.4 0.5 0.7 -0.6 0.8
Stomach or abdominal pain in last month 0.4 0.5 0.6 0.6 0.7
Supplements: Glucosamine 0.2 0.2 0.4 -0.6 -0.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 -0.2 0.3
Medication: Atenolol 0.8 1.0 1.2 1.1 0.9
Medication: Levothyroxine sodium 1.3 2.2 3.3 -1.8 -1.1
Sitting height 0.3 2.2 4.2 -2.0 -0.6
Chronic bronchitis/emphysema (father) 0.8 1.0 1.3 -1.1 -0.8
High blood pressure (mother) 0.4 0.6 1.0 -0.4 -1.0
Body mass index (BMI) 0.4 1.6 3.1 -1.8 -0.2
Impedance of leg (left) 0.3 1.5 2.6 0.6 -1.6
Leg predicted mass (left) 0.4 2.2 4.3 -2.1 -0.3
Trunk fat mass 1.1 4.6 6.9 -2.6 -1.6
Waist circumference 0.6 2.3 4.5 -2.1 -0.3
Number of incorrect matches in round 0.7 1.1 2.2 -1.5 -0.2
Past tobacco smoking 3.0 5.5 5.6 2.4 2.3
Alcohol usually taken with meals 4.2 6.8 7.3 2.5 2.7
Nervous feelings 0.6 1.2 2.4 1.6 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.5 -0.7 -0.5
Hearing difficulty/problems with background noise 0.2 0.3 0.6 0.2 0.8
Hair/balding pattern: Pattern 2 0.8 1.1 1.6 -0.7 -1.3
Had menopause 1.4 1.8 2.9 -1.7 -0.8
Had other major operations 0.1 0.2 0.3 -0.2 -0.5
Forced vital capacity (FVC) 1.0 4.0 5.4 -2.3 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.6 0.8 -0.4
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.5 -0.3 -0.7
Qualifications: None of the above 0.3 0.6 0.9 -0.5 -0.9
Financial difficulties in last 2 years 1.4 1.8 2.9 -1.7 -0.8
Mouth/teeth dental problems 0.4 0.6 0.9 -0.6 -0.9
Heart attack 0.0 0.0 0.0 -0.1 0.1
Allergy 1.3 2.9 4.0 -1.4 -2.0
Pain all over the body in last month 0.4 0.5 0.8 -0.4 -0.9
Diabetes (self-reported) 0.1 0.2 0.4 -0.6 0.1
Hayfever/allergic rhinitis (self-reported) 2.9 3.8 4.3 2.1 1.8
Medication: Ramipril 1.9 2.5 2.8 1.7 1.5
Medication: Simvastatin 0.4 0.6 1.1 0.0 -1.1
Fluid intelligence score 0.1 0.2 0.4 0.6 -0.2
Illnesses of siblings 0.6 0.9 0.9 1.0 0.9
Neuroticism score 0.0 0.1 0.2 -0.1 -0.4
Weight 0.6 3.1 5.9 -2.4 -0.5
Impedance of arm (right) 1.0 4.6 9.1 -0.2 -3.0
Arm fat percentage (right) 1.0 3.9 5.1 -2.2 -1.7
Trunk fat-free mass 0.2 1.2 1.6 -1.2 0.9
Hip circumference 0.5 2.3 4.5 -2.1 -0.4
Time employed in main current job 1.7 2.0 3.4 -0.7 -1.9
Alcohol intake versus 10 years previously 2.2 3.4 4.3 -1.6 -2.1
Father’s age at death 0.6 0.7 1.2 0.5 1.1
Worrier / anxious feelings 1.4 2.7 4.2 2.1 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.4 -0.6 -0.6
Falls in the last year 7.2 9.7 11.2 -3.3 -2.9
Hair/balding pattern: Pattern 3 3.2 4.8 5.0 2.2 2.1
Number of live births 0.2 0.2 0.4 -0.2 0.6
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 4.7 -2.2 -1.4
Pulse rate 0.1 0.1 0.2 -0.0 0.4
Happiness 0.1 0.1 0.2 0.1 0.4
Noisy workplace 1.5 1.9 3.2 -1.8 -0.8
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.0 0.2 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 0.1 -0.1
Mouth/teeth dental problems: Dentures 0.0 0.0 0.0 0.0 -0.1
Asthma 2.2 4.4 6.8 1.4 2.6
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 2.8 -1.7 -0.5
Medication: Cholesterol lowering 0.1 0.1 0.2 0.4 0.1
Depression (self-reported) 0.1 0.1 0.1 -0.1 -0.4
Medication: Lansoprazole 2.5 2.9 4.0 -1.3 -2.0
Prospective memory result 0.1 0.1 0.1 -0.0 -0.4
Lung cancer (father) 0.9 1.1 1.3 0.9 1.1
Illnesses of mother 0.5 0.6 0.7 0.7 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 2.1 -1.4 -0.8
Pulse wave Arterial Stiffness index 3.4 4.0 5.6 -2.4 -1.5
Impedance of arm (left) 0.7 3.4 6.7 0.2 -2.6
Arm fat mass (right) 1.1 4.3 6.9 -2.6 -1.4
Trunk predicted mass 0.2 1.1 1.5 -1.2 0.9
Standing height 0.1 1.4 2.4 -1.5 -0.7
Length of working week for main job 3.9 4.3 5.3 -2.3 -1.8
Exposure to tobacco smoke at home 0.0 0.0 0.1 -0.3 -0.2
Breastfed as a baby 0.7 0.9 1.0 0.9 -1.0
Tense / ‘highly strung’ 0.4 0.6 1.2 -0.3 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.0 -1.0 -0.8
Hair/balding pattern: Pattern 4 0.1 0.3 0.6 -0.8 -0.1
Birth weight of first child 0.4 0.8 1.2 1.1 0.6
Peak expiratory flow (PEF) 0.5 1.1 2.1 -1.5 -0.1
Pulse wave reflection index 0.3 0.3 0.5 -0.7 -0.5
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.6 0.1 -0.7
Loud music exposure frequency 5.0 5.5 6.4 -2.1 -2.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.2 0.3 0.5 0.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 0.5 0.9
Blood clot in the leg (DVT) 0.4 0.5 0.9 -0.2 0.9
Medication: Paracetamol 0.1 0.1 0.2 -0.4 -0.3
Headache pain in last month 0.7 1.2 1.4 1.0 1.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 0.9 0.9 0.8
Glaucoma (self-reported) 1.1 1.3 1.5 -1.2 -1.0
Gout (self-reported) 0.5 0.7 1.2 -1.1 -0.5
Hypothyroidism/myxoedema (self-reported) 1.8 3.4 4.9 -2.2 -1.4
Medication: Amlodipine 0.7 1.0 1.4 -0.8 -1.2
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 -0.9 -0.0
Birth weight 1.0 2.2 2.8 -1.2 -1.7
Chronic bronchitis/emphysema (mother) 2.0 2.3 3.3 -1.8 -1.2
High blood pressure (siblings) 1.8 2.5 2.6 -1.6 -1.6
Forced vital capacity (FVC), Best measure 0.4 1.4 2.0 -1.4 -0.8
Body fat percentage 0.8 3.3 4.2 -2.0 -1.6
Leg fat percentage (right) 0.7 2.6 3.8 -1.9 -1.2
Arm fat-free mass (right) 0.3 1.4 1.7 -1.3 1.1
Exposure to tobacco smoke outside home 1.8 2.4 4.3 -0.6 -2.1
Comparative body size at age 10 0.3 0.8 1.2 0.6 1.1
Number of full brothers 0.7 0.8 1.4 -1.2 -0.6
Worry too long after embarrassment 0.5 0.8 1.2 1.1 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.9 -0.9 -0.4
Wheeze or whistling in the chest in last year 0.6 1.0 1.1 -1.0 -1.0
Number of children fathered 2.4 2.7 3.8 1.9 1.3
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 2.3 -0.8 -1.5
Age at first live birth 0.2 0.3 0.5 0.7 0.3
Pulse wave peak to peak time 3.0 3.6 5.1 2.3 1.4
Health satisfaction 0.4 0.5 1.0 -0.2 -1.0
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.2 -0.4
Qualifications: College or University degree 0.0 0.1 0.1 0.3 -0.2
Eye problems/disorders: None of the above 1.1 1.3 1.5 1.2 1.0
Mouth/teeth dental problems: Loose teeth 8.1 9.6 11.8 -2.7 -3.4
Emphysema/chronic bronchitis 1.7 1.9 2.9 -1.0 -1.7
Medication for pain relief, constipation, heartburn 0.4 0.7 0.8 0.7 0.9
Neck or shoulder pain in last month 0.3 0.4 0.6 0.5 0.8
Medication: Blood pressure 0.2 0.4 0.4 -0.6 -0.6
Angina (self-reported) 0.1 0.1 0.2 0.1 -0.4
Migraine (self-reported) 0.4 0.5 0.6 -0.7 0.7
Medication: Ibuprofen 0.9 1.1 2.1 -1.5 0.1
Medication: Allopurinol 0.9 1.2 1.8 -1.4 -0.7
Medication: Omeprazole 2.3 2.8 3.6 -1.4 -1.9
Medication: Seretide 50 evohaler 2.1 2.4 3.2 -1.8 -1.2
Mean time to correctly identify matches 1.3 2.5 4.8 -0.4 -2.2
Heart disease (mother) 0.0 0.0 0.0 -0.1 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.0 2.0 -1.4 -1.4
Whole body fat mass 1.0 4.1 6.4 -2.5 -1.4
Leg fat mass (right) 0.9 3.4 5.6 -2.4 -1.1
Arm predicted mass (right) 0.2 1.2 1.7 -1.3 0.8
Pulse rate, automated reading 0.6 2.0 3.2 0.9 1.8
Alcohol intake frequency. 1.9 4.5 6.5 -1.6 -2.6
Comparative height size at age 10 0.0 0.1 0.1 -0.3 0.1
Number of full sisters 0.2 0.2 0.4 -0.7 0.2
Suffer from ‘nerves’ 0.2 0.3 0.3 0.5 -0.5
Overall health rating 2.2 4.8 5.8 -2.4 -1.9
Chest pain or discomfort 0.2 0.3 0.6 0.0 -0.8
Had major operations 1.1 1.3 2.0 0.8 1.4
Age at last live birth 0.2 0.2 0.4 -0.1 -0.7
Family relationship satisfaction 1.7 2.0 3.1 -1.8 -1.0
Leg pain on walking 0.8 1.0 1.4 -0.8 -1.2
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.6 -1.6 -0.3
Commuting to job workplace: Car/motor vehicle 2.3 2.6 4.3 2.1 1.0
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 0.1 -0.7
Medication: Aspirin 0.4 0.5 0.6 0.6 0.8
Supplements: Vitamin C 1.0 1.2 1.9 0.7 1.4
Knee pain experienced in last month 0.5 0.8 1.3 -1.1 -0.6
Hypertension (Self-reported) 1.0 2.8 4.2 -1.2 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.3 3.8 5.2 -1.6 -2.3
Illnesses of father: Heart disease 4.4 6.1 6.5 -2.5 -2.4
Illnesses of siblings: Diabetes 0.5 0.6 1.1 0.2 1.1
Smoking status: Previous 1.1 1.7 2.0 -1.4 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.1 -0.3 -0.2
Whole body fat-free mass 0.2 1.4 2.6 -1.6 0.4
Leg fat-free mass (right) 0.3 1.7 3.5 -1.9 -0.1
Arm fat percentage (left) 0.8 3.1 4.1 -2.0 -1.4
Average weekly red wine intake 0.3 0.5 0.8 0.4 0.9
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.1 0.2 -0.4
Mood swings 0.3 0.6 0.8 -0.9 -0.6
Loneliness, isolation 0.3 0.4 0.8 0.2 0.9
Long-standing illness, disability or infirmity 1.3 1.9 2.0 -1.4 -1.4
Ever had bowel cancer screening 5.5 6.4 7.3 -2.7 -2.4
Diabetes diagnosed by doctor 0.3 0.4 0.8 -0.2 0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 2.8 1.1 1.7
Friendships satisfaction 2.9 3.6 4.5 -2.1 -1.7
Qualifications: nursing, teaching 0.2 0.3 0.5 0.7 0.4
Commuting to job workplace: Walk 0.3 0.4 0.5 -0.7 -0.5
Eye problems/disorders: Cataract 0.3 0.4 0.5 -0.5 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.9 3.0 4.2 1.4 2.0
Medication for cholesterol 0.0 0.1 0.1 0.0 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.7 -0.7 -0.8
Back pain experienced in last month 0.2 0.3 0.5 -0.7 -0.2
Mineral and other dietary supplements 0.3 0.4 0.6 0.4 -0.8
Breast cancer (self-reported) 0.1 0.1 0.2 0.4 0.1
Asthma (self-reported) 1.8 3.6 5.5 1.3 2.4
Osteoporosis (self-reported) 0.9 1.1 1.6 0.8 1.2
Osteoarthritis (self-reported) 2.9 3.7 4.5 -1.7 -2.1
Medication: Aspirin 0.4 0.6 0.6 0.7 0.8
Medication: Gliclazide 0.2 0.2 0.5 -0.7 0.0
Illnesses of father: None of the above (group 1) 1.2 1.5 2.2 1.5 0.9
Smoking status: Current 2.2 3.5 4.4 -1.6 -2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 3.3 -1.8 -1.4
Whole body water mass 0.3 1.5 3.0 -1.7 0.4
Leg predicted mass (right) 0.3 1.7 3.4 -1.8 -0.1
Arm fat mass (left) 0.9 3.6 5.9 -2.4 -1.2
Number of self-reported non-cancer illnesses 0.0 0.1 0.2 0.1 -0.4
Average weekly champagne plus white wine intake 1.4 2.0 2.0 1.4 1.4
Miserableness 0.2 0.3 0.3 -0.5 -0.6
Guilty feelings 0.4 0.7 1.0 0.6 1.0
Wears glasses or contact lenses 1.0 1.2 1.9 -1.4 -0.7
Ever taken oral contraceptive pill 0.4 0.5 0.5 0.7 0.7
Hearing aid user 0.1 0.1 0.1 0.3 0.4
Mother’s age at death 0.3 0.4 0.5 -0.6 -0.7
Financial situation satisfaction 2.5 3.0 4.8 -2.2 -1.2
Tinnitus: Yes, now most or all of the time 2.8 3.2 4.9 -2.2 -1.3
Commuting to job workplace: Public transport 0.1 0.2 0.3 0.5 -0.3
Eye problems/disorders: Glaucoma 0.7 0.8 1.4 -1.2 -0.5
Medication: Blood pressure 0.6 1.2 2.2 -0.4 -1.5
Pain type(s) experienced in last month: Hip pain 4.9 6.2 7.1 -2.3 -2.7
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.1 0.7 1.5
High cholesterol (Self-reported) 1.0 1.7 2.3 -1.1 -1.5
Medication: Bendroflumethiazide 1.1 1.7 1.9 -1.2 -1.4
Medication: Paracetamol 0.0 0.1 0.1 0.1 0.3
Medication: Lisinopril 1.9 2.5 2.5 -1.6 -1.6
Medication: Atorvastatin 0.8 1.0 1.1 1.0 0.9
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.4 -0.0
Alcohol drinker status: Never 1.3 1.6 3.0 1.7 0.3
Ever smoked 1.4 2.4 2.9 -1.4 -1.7
Basal metabolic rate 0.3 1.9 3.8 -2.0 0.1
Leg fat percentage (left) 0.7 2.6 3.7 -1.9 -1.2
Arm fat-free mass (left) 0.4 2.2 4.5 -2.1 0.0
Number of operations (self-reported) 0.1 0.2 0.3 0.3 0.6
Average weekly beer plus cider intake 0.1 0.2 0.3 -0.5 -0.3
Irritability 1.0 1.6 1.9 -1.4 -1.2
Risk taking 0.5 0.8 1.5 -1.2 -0.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.6 0.8 0.3
Fractured/broken bones in last 5 years 1.0 1.3 1.6 -1.3 -1.0
Age started oral contraceptive pill 0.1 0.1 0.3 0.0 -0.5
Diastolic blood pressure, automated reading 6.4 19.9 22.9 -4.1 -4.8
Ever depressed for a whole week 0.4 0.5 0.9 0.3 -0.9
Unable to work because of sickness or disability 5.7 7.3 8.1 -2.8 -2.6
Commuting to job workplace: Cycle 2.2 2.7 2.8 -1.6 -1.7
Myopia 0.3 0.5 0.9 -0.3 -1.0
Vascular/heart problems diagnosed by doctor 0.5 1.2 2.1 0.6 1.5
Cholesterol lowering medication 0.4 0.5 0.9 0.3 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 2.5 -1.1 -1.6
Pain experienced in last month 0.4 0.6 1.2 1.1 -0.3
Supplements: Calcium 1.1 1.2 1.9 -1.4 -0.8
Basal cell carcinoma (self-reported) 0.6 0.7 1.0 1.0 0.6
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 -0.2 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 -0.1 0.9
Heart disease (siblings) 0.4 0.5 0.6 -0.6 -0.8
Alcohol drinker status: Previous 1.3 1.5 2.4 -0.8 -1.6
Pack years of smoking 2.6 3.8 5.5 -2.3 -1.4
Impedance of whole body 0.5 2.8 5.4 0.4 -2.3
Leg fat mass (left) 0.9 3.5 5.6 -2.4 -1.2
Arm predicted mass (left) 0.4 2.0 4.0 -2.0 0.2