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chr1:182,298,784-185,637,924

Best TWAS P=1.56e-155 · Best GWAS P=6.42e-158 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TSEN15	0.23	0.18	lasso	9	0.18	4.7e-21	26.7	26.6	1.6e-155	0.99	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	RGL1	0.15	0.01	lasso	4	0.01	1.1e-01	2.6	5.9	3.7e-09	0.04	0.11	0.05	FALSE
3	GTEx	Adipose Subcutaneous	RP11-181K3.4	0.09	0.11	enet	9	0.09	6.7e-08	10.5	10.5	1.2e-25	0.06	0.68	0.32	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-181K3.4	0.13	0.06	lasso	3	0.14	8.3e-08	10.5	10.8	4.9e-27	0.07	0.11	0.88	FALSE
5	GTEx	Adrenal Gland	EDEM3	0.11	0.01	enet	11	0.00	2.9e-01	-3.5	5.5	4.8e-08	-0.01	0.30	0.08	FALSE
6	GTEx	Adrenal Gland	ARPC5	0.13	0.06	lasso	8	0.04	1.2e-02	2.5	7.9	2.9e-15	0.25	0.12	0.44	FALSE
7	GTEx	Artery Aorta	RP11-181K3.4	0.17	0.01	enet	16	0.02	2.3e-02	10.5	9.5	1.8e-21	0.09	0.11	0.85	FALSE
8	GTEx	Artery Coronary	FAM129A	0.17	0.03	enet	26	0.08	1.4e-03	-4.9	5.2	2.6e-07	0.04	0.14	0.05	FALSE
9	GTEx	Artery Tibial	EDEM3	0.23	0.16	enet	24	0.19	1.7e-14	-3.3	5.3	1.4e-07	0.05	1.00	0.00	FALSE
10	GTEx	Artery Tibial	SMG7	0.11	0.02	lasso	3	0.04	2.8e-04	4.2	-5.9	3.9e-09	-0.09	0.35	0.02	FALSE
11	GTEx	Artery Tibial	LAMC1	0.10	0.10	lasso	5	0.10	2.2e-08	10.5	-10.4	1.5e-25	-0.06	0.18	0.82	FALSE
12	GTEx	Artery Tibial	TSEN15	0.10	0.07	lasso	5	0.05	6.3e-05	-10.4	-6.5	6.1e-11	-0.10	0.57	0.06	FALSE
13	GTEx	Artery Tibial	RP11-181K3.4	0.07	0.07	lasso	15	0.05	1.1e-04	10.5	10.8	2.9e-27	0.09	0.32	0.65	FALSE
14	GTEx	Brain Cerebellar Hemisphere	LAMC1	0.50	0.16	enet	13	0.13	3.8e-04	10.6	10.6	2.0e-26	0.06	0.07	0.91	FALSE
15	GTEx	Brain Cerebellar Hemisphere	TSEN15	0.38	0.08	lasso	13	0.16	5.3e-05	26.8	23.9	4.6e-126	0.90	0.01	0.98	FALSE
16	GTEx	Brain Cerebellum	LAMC1	0.27	0.36	enet	29	0.29	3.5e-09	10.6	10.9	1.9e-27	0.02	0.05	0.95	TRUE
17	GTEx	Brain Cerebellum	COLGALT2	0.49	0.05	lasso	8	0.10	9.2e-04	14.5	-14.2	1.0e-45	-0.39	0.09	0.29	FALSE
18	GTEx	Brain Frontal Cortex BA9	LAMC2	0.20	0.05	lasso	5	0.10	1.0e-03	-8.5	-8.0	1.2e-15	0.05	0.12	0.75	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	RP11-181K3.4	0.15	0.03	enet	30	0.06	3.8e-03	10.5	6.5	9.4e-11	0.04	0.04	0.87	FALSE
20	GTEx	Cells Transformed fibroblasts	RP11-181K3.4	0.05	0.01	lasso	2	0.01	1.2e-01	-7.4	7.3	1.9e-13	-0.01	0.05	0.62	FALSE
21	GTEx	Colon Transverse	TSEN15	0.17	0.05	enet	18	0.06	7.2e-04	15.2	18.3	5.6e-75	0.73	0.06	0.88	TRUE
22	GTEx	Esophagus Mucosa	EDEM3	0.09	0.02	enet	23	0.02	1.3e-02	2.4	5.2	2.2e-07	0.08	0.34	0.04	FALSE
23	GTEx	Esophagus Mucosa	LAMC1	0.17	0.01	enet	40	0.07	2.8e-05	-7.0	-7.3	2.6e-13	-0.03	0.05	0.90	FALSE
24	GTEx	Esophagus Mucosa	TSEN15	0.08	0.07	lasso	2	0.05	2.6e-04	-10.7	-10.7	1.2e-26	-0.21	0.66	0.01	TRUE
25	GTEx	Esophagus Muscularis	LAMC1	0.11	0.08	enet	9	0.03	4.4e-03	11.0	-10.7	6.9e-27	-0.05	0.02	0.97	FALSE
26	GTEx	Esophagus Muscularis	RP11-181K3.4	0.05	0.09	lasso	1	0.07	3.9e-05	10.7	10.7	6.2e-27	0.06	0.11	0.87	FALSE
27	GTEx	Lung	LAMC1	0.18	0.20	enet	33	0.19	2.3e-14	10.7	-10.7	8.8e-27	-0.07	0.18	0.82	FALSE
28	GTEx	Lung	COLGALT2	0.15	0.02	enet	15	0.08	1.5e-06	6.4	-13.2	1.3e-39	-0.25	0.29	0.20	TRUE
29	GTEx	Nerve Tibial	FAM129A	0.12	0.05	enet	11	0.10	1.5e-07	-4.9	5.9	2.8e-09	-0.05	0.97	0.00	TRUE
30	GTEx	Nerve Tibial	LAMC1	0.07	0.08	enet	30	0.05	1.1e-04	10.6	10.1	8.2e-24	0.10	0.23	0.76	FALSE
31	GTEx	Nerve Tibial	RP11-181K3.4	0.18	0.24	enet	30	0.24	2.9e-17	10.8	10.5	8.6e-26	0.06	0.44	0.56	FALSE
32	GTEx	Testis	RP11-181K3.4	0.10	0.09	enet	29	0.05	2.2e-03	10.8	8.0	1.0e-15	0.08	0.06	0.74	FALSE
33	GTEx	Thyroid	RP11-181K3.4	0.12	0.07	lasso	4	0.05	5.7e-05	10.5	10.5	5.3e-26	0.07	0.16	0.83	FALSE
34	GTEx	Uterus	NCF2	0.49	0.02	enet	56	0.06	2.1e-02	-1.1	-5.3	1.2e-07	-0.02	0.09	0.10	FALSE
35	GTEx	Whole Blood	LAMC1	0.08	0.05	enet	21	0.04	1.0e-04	10.5	10.2	1.7e-24	0.06	0.05	0.95	FALSE
36	GTEx	Whole Blood	ARPC5	0.08	0.02	enet	23	0.01	5.4e-02	2.1	7.1	1.5e-12	0.10	0.44	0.02	FALSE
37	GTEx	Whole Blood	COLGALT2	0.18	0.14	lasso	9	0.13	9.0e-12	7.5	-7.0	1.9e-12	-0.12	1.00	0.00	FALSE
38	METSIM	Adipose	COLGALT2	0.15	0.13	bslmm	539	0.13	3.1e-19	7.5	-5.7	1.1e-08	-0.09	1.00	0.00	FALSE
39	METSIM	Adipose	LAMC1	0.06	0.02	bslmm	480	0.03	2.2e-05	-9.0	6.5	5.9e-11	-0.01	0.09	0.89	FALSE
40	METSIM	Adipose	SMG7	0.10	0.01	blup	573	0.05	3.1e-08	4.2	-6.4	1.7e-10	-0.27	0.98	0.01	TRUE
41	METSIM	Adipose	TSEN15	0.06	0.02	enet	28	0.04	1.3e-06	26.7	22.6	5.1e-113	0.81	0.00	1.00	FALSE
42	NTR	Blood	GLT25D2	0.30	0.23	lasso	5	0.23	1.3e-73	7.5	-6.3	2.3e-10	-0.08	1.00	0.00	FALSE
43	NTR	Blood	LAMC1	0.05	0.07	lasso	11	0.07	3.7e-21	-9.1	10.1	3.7e-24	-0.03	0.56	0.44	FALSE
44	NTR	Blood	NCF2	0.02	0.01	bslmm	541	0.01	1.3e-03	2.1	5.5	2.9e-08	0.10	0.84	0.00	TRUE
45	YFS	Blood	FAM129A	0.06	0.06	lasso	10	0.06	5.7e-20	-5.3	-5.5	3.4e-08	0.01	1.00	0.00	FALSE
46	YFS	Blood	LAMC1	0.10	0.17	lasso	21	0.17	2.7e-52	-9.1	9.9	3.1e-23	-0.03	1.00	0.00	FALSE
47	YFS	Blood	TSEN15	0.04	0.01	blup	513	0.02	1.1e-07	17.1	9.1	9.0e-20	0.37	0.63	0.34	TRUE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	C1orf26	0.07	0.02	blup	71	0.05	1.0e-03	3.8	5.8	5.5e-09	0.12	0.04	0.50	TRUE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	GLT25D2	0.10	0.05	lasso	2	0.04	3.9e-03	7.5	-7.5	5.3e-14	-0.12	0.17	0.05	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GLT25D2	0.05	0.01	enet	10	0.04	6.3e-05	7.5	-20.2	8.3e-91	-0.59	0.03	0.72	TRUE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TSEN15	0.06	0.02	enet	13	0.04	1.7e-05	-10.7	5.8	6.5e-09	0.30	0.11	0.22	TRUE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GLT25D2	0.11	0.02	blup	119	0.05	5.1e-06	-6.9	-14.9	5.5e-50	-0.54	0.13	0.37	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LAMC1	0.04	0.03	blup	108	0.04	1.2e-05	10.8	-9.6	5.2e-22	-0.07	0.10	0.88	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TSEN15	0.07	0.05	blup	52	0.06	1.7e-07	17.1	8.4	3.0e-17	0.42	0.60	0.34	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FAM129A	0.20	0.01	enet	21	0.06	2.8e-04	-3.5	5.5	3.4e-08	0.01	0.28	0.10	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	C1orf26	0.03	0.01	blup	71	0.02	8.5e-04	4.5	5.4	5.5e-08	0.12	0.03	0.55	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	GLT25D2	0.15	0.10	enet	12	0.11	4.5e-12	6.4	-7.0	3.7e-12	0.03	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	LAMC2	0.11	0.09	enet	14	0.09	5.9e-10	-3.7	-6.0	2.2e-09	0.02	0.98	0.02	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSEN15	0.11	0.08	blup	52	0.10	6.7e-12	26.8	22.8	7.1e-115	0.84	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	GLT25D2	0.06	0.04	lasso	1	0.03	1.7e-04	7.5	-7.5	5.8e-14	-0.12	0.21	0.04	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TSEN15	0.04	0.00	blup	52	0.02	5.3e-03	-10.7	5.5	4.9e-08	0.41	0.04	0.12	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	C1orf21	0.07	0.07	lasso	4	0.06	2.4e-07	-7.0	-7.0	2.7e-12	-0.05	0.28	0.71	TRUE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	TSEN15	0.15	0.12	lasso	3	0.12	3.3e-12	-10.7	-5.3	1.3e-07	-0.04	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	TSEN15	0.10	0.00	blup	52	0.02	1.2e-02	-10.4	7.9	2.2e-15	0.45	0.01	0.33	FALSE
65	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TSEN15	0.16	0.00	blup	52	0.04	1.2e-02	-11.1	11.2	4.4e-29	0.43	0.02	0.15	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	GLT25D2	0.09	0.00	blup	119	0.04	5.4e-05	2.5	-10.2	2.5e-24	-0.34	0.04	0.17	TRUE
67	The Cancer Genome Atlas	Thyroid Carcinoma	LAMC1	0.06	0.04	blup	109	0.05	1.3e-05	10.5	-9.4	3.3e-21	-0.10	0.08	0.91	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	TSEN15	0.22	0.02	blup	52	0.11	1.1e-10	15.3	7.9	3.2e-15	0.43	0.01	0.99	FALSE