Hub : Genes

RGL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1530	0.0500	7.3e-04	0.009	NA	0.003	NA	0.005	5.7e-02	NA	1.7e-01	NA	1.1e-01
2	YFS	Blood	0.0858	0.0174	3.3e-16	0.037	0.061	0.054	0.059	0.047	4.0e-12	3.2e-19	3.7e-17	1.1e-18	5.3e-15
3	TCGA	Liver Hepatocellular Carcinoma	0.1620	0.0860	6.3e-03	-0.006	0.017	0.022	NA	-0.003	7.8e-01	4.9e-02	3.2e-02	NA	5.0e-01
4	TCGA	Prostate Adenocarcinoma	0.0507	0.0274	7.2e-03	-0.002	0.010	0.020	NA	0.005	6.4e-01	3.1e-02	2.9e-03	NA	9.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.8	-0.3	0.1	0.9	0.0
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	0.4	-0.3	0.1	0.1
Depressed Affect (Nagel 2018)	0.5	1.0	3.1	0.0	-0.9	-1.8	0.1
Depression (Nagel 2018)	0.4	0.6	1.4	0.5	0.0	-0.9	1.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.2	0.7	-0.3	-0.7
Neuroticism (Nagel 2018)	0.3	0.8	2.3	0.0	1.5	0.1	1.0
Schizophrenia (2018)	0.1	0.2	0.5	0.7	-0.4	-0.6	0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.6	-0.8	-0.5	0.0
Worry (Nagel 2018)	1.0	2.1	3.4	0.8	1.8	1.0	1.9
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.0	0.2	-0.4	0.3
Alzheimer’s Disease (in father)	1.8	2.0	5.9	0.8	-1.1	-0.5	2.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	0.4	-0.6	-0.7	1.1
Crohns Disease (2017)	0.5	1.2	2.2	-0.4	-1.2	0.8	-1.5
Irritable Bowel Disease (IBD)	0.6	1.4	3.0	0.6	-1.7	-0.5	-1.4
Ulcerative Colitis (UC)	0.8	1.6	2.2	1.2	-1.3	-1.5	-0.9
Major Depression (MDD)	3.8	4.7	11.4	3.4	-0.8	-0.3	2.6
Reaction Time	1.4	2.6	6.4	-1.6	0.7	2.5	1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	1.2	0.6	-0.7	-0.0
Breast Cancer	0.6	1.5	3.4	-0.4	1.4	0.6	1.9
Ovarian Cancer	0.4	0.6	1.1	0.5	-0.9	-0.2	1.1
Prostate Cancer	0.4	0.5	1.1	-0.4	-0.9	-1.0	0.1
Age at First Birth	3.2	4.6	9.6	-1.6	3.1	2.1	1.5
Bipolar Disorder (2011)	0.2	0.2	0.4	0.1	-0.5	-0.0	0.6
Body Mass Index (BMI) (2010)	0.4	0.5	1.8	0.5	-1.4	0.1	-0.3
Coronary Artery Disease (CAD)	0.5	0.6	1.8	-0.1	-0.7	1.4	-0.4
Crohns Disease (2012)	0.2	0.3	0.5	-0.3	-0.3	0.7	-0.6
Mean Putamen Volume	2.0	2.2	5.4	-2.3	1.0	1.0	-1.3
Fasting Glucose	0.5	0.6	1.3	-0.6	0.8	0.4	1.1
HbA1C	0.2	0.2	0.3	-0.5	0.6	-0.3	-0.5
HDL Cholesterol	1.0	1.6	4.6	-2.1	0.2	0.4	-1.3
LDL Cholesterol	0.6	1.0	2.1	0.2	-1.3	-1.4	0.5
Lupus	0.7	1.0	3.6	1.9	-0.2	-0.5	-0.0
Neuroticism (2016)	0.5	0.7	1.8	0.4	1.3	0.4	0.9
Primary Biliary Cirrhosis	0.3	0.4	0.7	0.5	0.2	-0.8	-0.8
Rheumatoid Arthritis	1.0	1.4	4.3	-2.1	0.1	-1.0	-0.5
Schizophrenia (2014)	0.3	0.6	1.2	1.1	-0.8	-0.7	0.3
Triglycerides	0.6	0.9	1.8	1.3	-0.0	-0.5	1.4
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.0	-0.2	-1.3	0.9	-1.4
Ulcerative Colitis	0.5	0.8	2.1	1.0	-1.5	-0.1	0.3
Blood Eosinophil Count	0.2	1.9	6.7	0.1	-1.0	-2.6	0.2
Blood Platelet Count	0.0	0.3	0.8	-0.3	-0.4	-0.9	-0.0
Blood Red Count	0.3	2.8	7.1	-2.7	-0.8	1.0	-1.6
Blood White Count	0.2	1.6	4.4	0.1	1.2	2.1	0.7
Heel T-Score	0.3	2.1	8.2	-0.1	-0.2	0.3	2.9
BMI	0.5	2.8	5.0	-0.6	-2.2	-2.2	-0.9
Height	0.8	14.7	34.7	5.9	4.8	-0.8	-0.4
Waist Hip Ratio (WHR)	0.4	1.6	4.0	-0.7	1.3	0.5	2.0
Systolic Blood Pressure	0.3	1.4	4.8	0.6	2.2	0.2	-0.4
Smoking Status	0.8	2.0	3.6	1.7	-1.9	-0.6	-1.1
Allergy or Eczema	0.1	0.4	0.6	-0.7	0.5	0.3	-0.8
Cardiovascular Disease	0.7	2.2	4.9	-1.7	0.2	-0.8	-2.2
Hypothyroidism (self reported)	0.7	1.6	2.5	0.8	1.6	1.3	1.3
Respiratory disease	0.6	1.3	3.0	-1.7	-0.7	0.3	-1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	0.3	0.7	-1.3	0.6
Lung FEV1/FVC ratio	1.1	5.5	13.7	3.7	-1.2	-2.5	-0.7
Lung FVC	0.1	0.4	1.0	-0.2	-0.1	-1.0	-0.6
Neuroticism	0.4	1.1	2.2	0.2	1.5	-0.3	1.4
Chronotype (morning person)	1.9	4.5	14.0	0.9	-3.7	-1.6	0.6
Hair Pigment	0.1	1.8	3.6	1.9	1.5	0.2	-1.2
Tanning	0.1	1.4	5.4	0.2	-2.3	-0.2	0.5
Hand grip strength (left)	0.1	0.4	0.7	-0.4	0.6	-0.9	-0.5
Number of treatments/medications taken	0.6	1.0	2.4	-1.2	-0.4	0.2	-1.6
Average weekly spirits intake	0.5	0.7	2.2	-0.5	1.5	0.3	-0.3
Sensitivity / hurt feelings	0.3	0.5	1.1	0.0	-0.4	-1.1	0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.2	0.5	-0.8	0.4
Hearing difficulty/problems: Yes	0.2	0.3	1.2	-1.1	-0.3	0.2	-0.2
Relative age of first facial hair	0.6	1.1	2.5	-1.6	1.0	0.9	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.9	-0.1	0.3	0.2
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.5	1.9	-1.7	0.7	-0.7
Ever had hysterectomy (womb removed)	2.1	2.4	5.5	1.6	-2.3	1.3	0.0
Systolic blood pressure, automated reading	0.3	0.9	1.2	1.1	0.9	1.0	0.7
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.6	0.1	0.8	1.6	0.4
Angina	0.1	0.2	0.3	0.1	0.5	-0.4	0.6
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.1	-0.9	-0.0	-0.9
Vitamin and mineral supplements	1.3	1.7	3.5	-1.3	-1.3	-0.2	-1.9
Supplements: Zinc	3.3	3.6	6.7	2.6	-1.4	0.6	2.3
Medication: Co-codamol	3.1	3.6	11.0	0.2	-1.8	-3.3	-0.5
Medication: Metformin	0.2	0.3	0.7	-0.3	0.8	-0.8	0.0
Diabetes (father)	2.0	2.5	5.6	1.8	-0.7	0.6	2.4
Diabetes (mother)	0.3	0.4	1.3	-0.2	-0.2	1.2	0.0
Severe depression (siblings)	1.7	2.0	3.5	1.9	-1.1	-0.1	1.8
Pack years adult smoking proportion	0.0	0.1	0.1	0.3	0.2	-0.3	-0.2
Impedance of leg (right)	1.6	7.6	15.3	1.3	3.9	2.2	3.0
Leg fat-free mass (left)	0.5	2.9	4.9	1.7	-1.4	-2.2	-1.3
Trunk fat percentage	0.4	1.4	2.7	1.6	-0.3	-0.9	1.5
Hand grip strength (right)	0.4	1.1	4.4	-0.3	0.2	-2.1	0.1
Townsend deprivation index at recruitment	0.5	0.7	1.8	0.2	-0.7	-0.5	-1.4
Current tobacco smoking	1.7	2.8	4.0	2.0	-1.3	-1.7	-1.6
Average weekly fortified wine intake	0.9	1.0	1.7	1.1	1.3	0.6	1.0
Maternal smoking around birth	1.9	2.7	8.9	1.1	-3.0	-0.7	-0.3
Fed-up feelings	0.4	0.8	2.7	-0.5	1.6	-0.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.7	0.8	1.3	0.3	1.2
Relative age voice broke	1.1	1.7	4.3	-2.1	0.9	-1.2	-0.4
Taking other prescription medications	0.6	0.9	3.2	-0.7	-0.0	-0.1	-1.8
Age when periods started (menarche)	0.4	0.9	1.8	-1.1	0.4	1.3	0.7
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	7.6	-0.3	-2.8	0.8	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.6	-0.9	1.2	-1.2	0.3
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.4	1.5	0.8	-2.1	0.2
Qualifications: CSEs or equivalent	1.2	1.5	4.4	0.4	-1.1	-2.1	0.5
Serious illness, injury or assault to yourself	2.1	2.6	6.6	2.6	-0.9	-1.2	1.3
High blood pressure	0.5	1.5	4.4	-0.6	0.1	-1.0	-2.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.6	-0.6	0.5	-0.8	-0.7
Multivitamins +/- minerals	0.5	0.7	2.2	0.4	0.1	0.6	1.5
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.1	-0.3	0.2	-0.5
Supplements: Glucosamine	0.8	1.1	3.2	-0.3	1.8	1.1	0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.3	1.2	-0.2	0.7	1.0
Medication: Atenolol	0.9	1.1	3.2	-0.7	0.3	-0.8	-1.8
Medication: Levothyroxine sodium	2.2	3.7	8.0	2.8	0.9	1.0	2.3
Sitting height	0.7	4.9	10.1	3.2	0.8	-0.6	-2.9
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	0.2	-1.1	-0.8	-0.3
High blood pressure (mother)	0.7	1.0	1.7	0.6	0.6	1.2	1.3
Body mass index (BMI)	0.9	3.7	8.1	0.3	-2.9	-2.5	-0.4
Impedance of leg (left)	1.4	6.6	13.6	1.2	3.7	1.6	3.0
Leg predicted mass (left)	0.6	3.0	5.0	1.6	-1.4	-2.2	-1.4
Trunk fat mass	0.4	1.7	3.5	1.9	-0.4	-1.5	0.9
Waist circumference	0.3	1.0	1.7	1.3	-0.3	-1.3	0.8
Number of incorrect matches in round	0.7	1.2	2.7	-0.1	1.5	1.6	0.1
Past tobacco smoking	0.3	0.6	1.2	0.1	1.1	0.4	1.1
Alcohol usually taken with meals	0.6	1.0	2.4	-1.1	0.7	1.6	0.2
Nervous feelings	1.4	2.6	5.3	0.5	2.3	1.4	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.3	-0.8	1.1	-0.1	1.1
Hearing difficulty/problems with background noise	0.6	1.0	3.9	-2.0	-0.1	0.3	-0.3
Hair/balding pattern: Pattern 2	0.8	1.0	2.4	0.8	0.8	0.5	1.5
Had menopause	0.7	0.8	2.0	0.8	0.8	1.4	0.2
Had other major operations	0.3	0.4	0.5	-0.2	0.7	0.6	0.7
Forced vital capacity (FVC)	0.2	0.7	0.9	0.8	1.0	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.1	-1.4	0.5	-1.1	-0.3
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	5.0	0.9	-2.2	-1.3	-0.2
Qualifications: None of the above	0.4	0.8	1.2	0.4	-1.0	1.1	1.0
Financial difficulties in last 2 years	1.3	1.7	5.2	-0.4	-2.3	-0.9	0.8
Mouth/teeth dental problems	0.5	0.8	1.5	-0.0	-1.2	-1.2	0.5
Heart attack	0.7	0.9	2.7	-0.5	-1.6	-0.7	0.4
Allergy	0.5	1.1	1.9	1.3	0.3	0.8	1.4
Pain all over the body in last month	0.7	0.7	1.9	0.7	0.6	0.4	1.4
Diabetes (self-reported)	0.2	0.3	0.6	0.1	0.8	-0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.1	-1.1	0.2	0.4	-0.3
Medication: Ramipril	0.8	1.0	2.2	0.6	1.5	-0.7	-1.1
Medication: Simvastatin	0.7	1.0	2.0	-1.4	-0.0	0.9	-1.0
Fluid intelligence score	0.6	1.2	2.3	-0.8	1.2	-0.4	-1.5
Illnesses of siblings	0.0	0.1	0.1	-0.3	0.1	0.0	-0.4
Neuroticism score	0.5	1.0	1.7	-0.3	1.1	-1.1	1.3
Weight	0.5	2.5	4.9	2.2	-0.8	-2.1	-0.3
Impedance of arm (right)	1.2	5.6	7.8	1.0	2.8	2.4	2.8
Arm fat percentage (right)	0.5	1.8	3.2	0.6	-1.6	-1.8	1.0
Trunk fat-free mass	0.4	2.3	3.6	1.6	0.1	-1.7	-1.9
Hip circumference	0.4	1.6	3.8	2.0	-0.4	-1.5	0.1
Time employed in main current job	0.5	0.6	0.8	-0.2	0.9	0.9	0.8
Alcohol intake versus 10 years previously	1.1	1.7	3.5	0.2	-1.7	-1.9	0.7
Father’s age at death	1.5	2.1	4.0	0.9	2.0	0.2	1.8
Worrier / anxious feelings	0.9	1.7	4.0	-2.0	1.0	1.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.0	0.5	0.0	0.2
Falls in the last year	0.6	0.8	1.2	1.1	-1.0	1.0	-0.1
Hair/balding pattern: Pattern 3	0.8	1.2	3.0	1.7	-0.3	-0.5	1.1
Number of live births	1.0	1.4	3.1	-0.3	-1.8	0.8	1.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.0	1.2	0.5	-1.4	-0.7
Pulse rate	0.4	0.6	1.4	0.9	-0.5	-1.2	-0.1
Happiness	2.4	2.9	4.0	-1.2	-2.0	-2.0	-1.5
Noisy workplace	0.9	1.2	4.1	2.0	-0.3	0.5	0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.0	-0.6	-0.0	-2.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.6	-0.7	-0.0	-0.0
Mouth/teeth dental problems: Dentures	0.9	1.4	3.3	1.0	-1.1	1.8	-0.6
Asthma	0.9	1.8	5.5	-2.3	0.5	-0.3	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	-1.2	0.0	-1.3	-0.8
Medication: Cholesterol lowering	0.3	0.4	1.7	-1.3	0.0	-0.0	-0.1
Depression (self-reported)	0.2	0.3	0.5	0.7	-0.0	0.5	0.5
Medication: Lansoprazole	0.2	0.2	0.7	-0.9	0.0	-0.3	0.4
Prospective memory result	0.2	0.2	0.7	0.8	-0.2	0.1	-0.1
Lung cancer (father)	1.0	1.2	2.2	0.8	-0.8	1.0	1.5
Illnesses of mother	0.9	1.1	3.3	0.0	1.8	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.4	1.8	-0.1	-1.9	-1.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	1.3	0.7	-0.3	0.0
Impedance of arm (left)	0.8	3.5	5.8	0.3	2.4	1.9	2.1
Arm fat mass (right)	0.5	1.9	4.9	1.1	-1.3	-2.2	0.3
Trunk predicted mass	0.4	2.3	3.3	1.7	-0.1	-1.7	-1.8
Standing height	0.9	9.0	20.5	3.8	4.5	0.7	-0.3
Length of working week for main job	0.4	0.5	0.7	-0.3	-0.8	0.9	0.7
Exposure to tobacco smoke at home	2.1	2.4	5.1	-1.7	-0.1	-1.3	-2.2
Breastfed as a baby	0.8	1.0	3.0	0.4	0.8	1.7	0.3
Tense / ‘highly strung’	0.8	1.3	3.9	-0.0	2.0	-0.4	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.4	1.2	-1.0	-0.5	1.0
Hair/balding pattern: Pattern 4	0.4	1.1	2.4	-1.6	1.0	-0.1	-0.9
Birth weight of first child	1.6	2.9	5.3	-2.3	1.2	2.1	0.3
Peak expiratory flow (PEF)	0.1	0.2	0.7	-0.2	-0.9	0.3	-0.3
Pulse wave reflection index	0.2	0.3	0.7	0.9	0.5	0.1	0.0
Ever highly irritable/argumentative for 2 days	1.6	1.9	5.1	1.1	1.2	0.1	2.3
Loud music exposure frequency	0.3	0.3	0.6	0.7	-0.4	-0.6	0.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.9	-1.0	-0.1	-1.3	-1.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.3	-0.4	1.5	-0.5	0.5
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.7	0.4	-0.4	0.9
Medication: Paracetamol	0.2	0.3	0.5	-0.6	-0.6	0.1	-0.7
Headache pain in last month	0.2	0.3	0.7	-0.8	0.2	0.0	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.9	-0.7	0.0	0.2
Glaucoma (self-reported)	0.5	0.6	1.4	0.4	1.2	0.9	0.3
Gout (self-reported)	1.1	1.6	5.7	-2.4	0.1	0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.2	0.8	1.8	1.0	1.3
Medication: Amlodipine	1.4	2.0	4.3	-2.1	-0.7	-0.3	-1.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.5	-0.7	-0.8	0.2	-1.2
Birth weight	1.7	3.7	12.9	-3.6	-0.0	0.9	-1.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.2	0.8	-0.5	-1.1	-0.3
High blood pressure (siblings)	0.1	0.2	0.3	-0.3	-0.4	0.5	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	1.9	1.4	0.4	-1.2	-0.9
Body fat percentage	0.4	1.5	1.8	1.3	-0.8	-1.4	1.3
Leg fat percentage (right)	0.5	1.8	2.7	1.0	-1.6	-1.5	1.1
Arm fat-free mass (right)	0.5	2.6	4.5	1.8	-0.3	-2.1	-1.6
Exposure to tobacco smoke outside home	3.9	5.2	12.9	2.6	0.1	1.2	3.6
Comparative body size at age 10	0.3	0.9	3.5	-1.9	0.3	-0.1	0.3
Number of full brothers	0.2	0.3	0.8	-0.9	0.3	-0.4	0.4
Worry too long after embarrassment	0.8	1.4	2.4	-1.6	1.0	-0.0	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	-0.2	-1.3	-0.0	-0.1
Wheeze or whistling in the chest in last year	0.6	1.2	2.2	-0.2	-1.5	-1.4	-0.6
Number of children fathered	1.8	2.1	4.0	1.0	-1.8	0.1	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.9	-1.0	0.6	0.9	0.3
Age at first live birth	0.9	1.7	4.5	-1.2	2.1	0.5	0.6
Pulse wave peak to peak time	0.4	0.5	1.7	-1.3	-0.3	0.2	-0.1
Health satisfaction	1.2	1.6	3.1	-0.6	-1.8	-0.8	-1.5
Shortness of breath walking on level ground	2.3	2.8	8.2	1.7	-2.9	-0.2	0.4
Qualifications: College or University degree	0.1	0.3	0.7	0.8	-0.5	0.2	0.4
Eye problems/disorders: None of the above	1.9	2.2	3.3	-1.1	-1.8	-1.5	-1.5
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.4	0.1	-0.2	-1.3	-1.6
Emphysema/chronic bronchitis	0.4	0.4	1.3	0.0	-0.6	0.3	-1.1
Medication for pain relief, constipation, heartburn	0.6	1.1	1.8	0.9	1.4	1.0	0.9
Neck or shoulder pain in last month	0.8	1.2	3.0	-0.7	1.7	0.8	-0.8
Medication: Blood pressure	0.1	0.2	0.6	-0.2	0.7	0.0	0.1
Angina (self-reported)	0.1	0.2	0.5	-0.1	0.4	-0.7	0.3
Migraine (self-reported)	0.7	0.8	1.6	0.1	1.2	-1.3	0.3
Medication: Ibuprofen	0.7	0.9	2.0	-1.4	0.3	-1.0	-0.7
Medication: Allopurinol	1.3	1.7	4.0	-2.0	0.8	1.4	0.2
Medication: Omeprazole	0.1	0.1	0.3	0.6	-0.4	0.3	-0.2
Medication: Seretide 50 evohaler	1.1	1.2	4.6	-0.3	-0.4	2.1	0.3
Mean time to correctly identify matches	1.3	2.5	7.0	-0.6	1.1	2.6	1.1
Heart disease (mother)	0.9	1.1	2.5	-0.9	-0.9	1.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.2	-0.2	-0.7	-1.8	-0.0
Whole body fat mass	0.4	1.7	3.6	1.6	-0.7	-1.9	0.6
Leg fat mass (right)	0.5	2.0	3.5	1.5	-1.3	-1.9	0.6
Arm predicted mass (right)	0.5	2.6	4.1	1.9	-0.3	-2.0	-1.5
Pulse rate, automated reading	0.2	0.7	1.8	1.4	0.9	0.1	0.3
Alcohol intake frequency.	2.0	4.7	18.1	0.3	-4.2	0.5	-0.6
Comparative height size at age 10	2.7	14.7	26.7	4.0	5.2	4.0	0.6
Number of full sisters	2.0	2.4	4.6	2.2	-1.1	-1.8	0.8
Suffer from ‘nerves’	0.9	1.4	2.6	1.2	1.1	0.3	1.6
Overall health rating	0.1	0.2	0.6	0.3	-0.2	-0.8	-0.3
Chest pain or discomfort	0.4	0.6	1.6	-1.2	-0.2	0.4	0.7
Had major operations	0.8	0.9	1.5	0.8	-1.1	-0.5	1.2
Age at last live birth	0.2	0.4	0.9	-0.6	0.5	-0.0	1.0
Family relationship satisfaction	0.9	1.1	2.6	0.3	1.3	-1.6	-0.2
Leg pain on walking	2.2	2.8	4.5	1.9	2.1	1.1	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	0.3	0.9	-1.4	0.2
Commuting to job workplace: Car/motor vehicle	2.0	2.3	4.2	1.1	-2.1	0.1	1.9
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	5.9	-1.4	2.4	1.5	-1.7
Medication: Aspirin	0.5	0.6	1.7	0.1	-1.3	-0.9	-0.0
Supplements: Vitamin C	0.3	0.3	0.7	0.8	-0.2	0.1	0.9
Knee pain experienced in last month	1.0	1.5	2.8	1.7	-0.9	-1.5	-0.5
Hypertension (Self-reported)	0.7	1.8	5.4	-0.7	-0.0	-1.2	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	-0.3	0.3	0.6	-1.0
Illnesses of father: Heart disease	0.7	1.0	2.0	-0.6	-1.4	0.5	-1.2
Illnesses of siblings: Diabetes	0.8	1.0	2.4	1.1	0.7	-1.6	0.0
Smoking status: Previous	0.2	0.2	0.6	-0.4	-0.0	0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	7.3	0.5	2.7	-1.2	-0.1
Whole body fat-free mass	0.5	2.8	4.2	1.8	-0.5	-2.1	-1.8
Leg fat-free mass (right)	0.6	3.1	5.6	1.6	-1.4	-2.4	-1.6
Arm fat percentage (left)	0.6	2.3	4.9	0.4	-1.9	-2.2	0.8
Average weekly red wine intake	0.4	0.5	1.2	-0.9	1.1	0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.8	-0.5	0.7	1.3	1.3
Mood swings	0.3	0.5	1.2	-0.3	0.5	-0.6	1.1
Loneliness, isolation	0.2	0.2	0.8	0.3	0.2	0.2	0.9
Long-standing illness, disability or infirmity	0.4	0.7	1.0	-1.0	-0.3	0.8	-1.0
Ever had bowel cancer screening	2.0	2.4	4.5	1.2	2.1	1.9	0.0
Diabetes diagnosed by doctor	0.6	0.9	1.6	-1.1	0.3	-1.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.1	0.3	-0.8	0.5
Friendships satisfaction	0.5	0.6	2.2	-0.0	0.2	-0.3	-1.5
Qualifications: nursing, teaching	0.3	0.5	0.9	-0.8	-1.0	0.5	-0.5
Commuting to job workplace: Walk	1.4	1.6	3.1	-1.3	1.8	0.8	-0.9
Eye problems/disorders: Cataract	1.1	1.3	2.1	-1.2	1.5	0.3	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.1	0.0	1.4	1.5	0.6
Medication for cholesterol	1.1	1.7	3.3	1.1	1.4	0.5	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.2	-1.2	1.5	0.4	-0.9
Back pain experienced in last month	0.8	1.2	3.0	-0.2	-1.2	-0.7	-1.7
Mineral and other dietary supplements	0.9	1.2	3.5	0.2	-1.9	-1.0	-0.6
Breast cancer (self-reported)	0.2	0.2	0.6	0.2	0.8	-0.3	-0.3
Asthma (self-reported)	1.2	2.4	6.2	-2.5	0.7	-0.5	-1.6
Osteoporosis (self-reported)	0.6	0.8	1.4	0.3	-1.2	-1.0	-0.9
Osteoarthritis (self-reported)	0.4	0.5	1.1	0.9	-0.0	-1.1	-0.3
Medication: Aspirin	0.3	0.4	1.0	0.2	-0.9	-1.0	0.0
Medication: Gliclazide	1.1	1.3	4.3	-2.1	0.8	-0.3	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	-0.6	1.3	-0.2	0.0
Smoking status: Current	1.9	3.1	4.3	2.0	-1.4	-2.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.3	-0.2	-0.1	-0.2	-0.6
Whole body water mass	0.5	2.9	4.5	1.8	-0.5	-2.1	-1.9
Leg predicted mass (right)	0.6	3.2	5.7	1.6	-1.4	-2.4	-1.6
Arm fat mass (left)	0.5	2.1	5.6	1.0	-1.3	-2.4	0.3
Number of self-reported non-cancer illnesses	1.0	1.7	3.3	-1.8	-0.9	-0.9	-1.3
Average weekly champagne plus white wine intake	0.9	1.2	2.6	0.2	1.4	0.4	1.6
Miserableness	1.0	1.8	4.3	-1.1	0.1	-2.1	-1.2
Guilty feelings	1.1	1.7	2.5	-1.4	1.2	1.6	0.9
Wears glasses or contact lenses	0.6	0.7	1.8	0.6	0.6	1.4	0.0
Ever taken oral contraceptive pill	0.4	0.5	1.6	-0.2	-0.5	-1.3	0.3
Hearing aid user	0.6	0.7	2.0	-0.7	-1.4	0.2	0.5
Mother’s age at death	0.1	0.1	0.4	0.2	0.6	-0.3	0.3
Financial situation satisfaction	1.9	2.4	6.5	-1.0	-1.4	-2.5	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	0.2	-0.9	0.7	0.1
Commuting to job workplace: Public transport	3.3	4.0	5.6	1.3	2.2	2.0	2.4
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	0.7	0.6	0.7	0.3
Medication: Blood pressure	1.4	2.6	7.6	-0.9	-1.3	-0.6	-2.8
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.8	1.7	1.0	0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	0.1	1.2	0.7	1.0
High cholesterol (Self-reported)	0.4	0.6	1.8	-1.3	-0.1	-0.7	-0.4
Medication: Bendroflumethiazide	0.2	0.4	1.0	-0.4	-0.4	-0.4	-1.0
Medication: Paracetamol	0.2	0.3	0.8	-0.5	-0.9	-0.1	-0.6
Medication: Lisinopril	0.4	0.6	1.7	-0.1	0.6	-0.5	1.3
Medication: Atorvastatin	0.4	0.5	1.1	-0.6	-1.1	-0.4	-0.5
Illnesses of father: High blood pressure	0.6	0.7	1.4	1.2	1.1	0.2	-0.1
Alcohol drinker status: Never	0.9	1.1	2.1	-0.7	-1.3	1.4	-0.6
Ever smoked	0.5	0.8	1.2	0.6	-1.1	-0.9	-1.0
Basal metabolic rate	0.5	3.0	5.6	1.9	-0.7	-2.4	-1.5
Leg fat percentage (left)	0.7	2.4	4.2	0.9	-1.8	-2.1	1.1
Arm fat-free mass (left)	0.5	2.4	5.6	2.4	-0.1	-1.7	-1.0
Number of operations (self-reported)	1.1	1.7	2.9	1.7	-1.3	0.6	1.3
Average weekly beer plus cider intake	2.1	3.1	4.8	2.1	1.4	-2.2	1.0
Irritability	1.3	2.2	5.1	0.9	2.3	-0.6	1.6
Risk taking	2.5	3.7	6.6	2.6	-0.1	-1.3	2.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.8	0.6	0.6	0.9	0.7
Fractured/broken bones in last 5 years	2.0	2.6	8.4	0.0	-1.3	-2.9	-0.2
Age started oral contraceptive pill	1.5	1.9	3.8	1.2	2.0	0.1	1.5
Diastolic blood pressure, automated reading	1.0	3.1	3.3	-1.6	-1.8	-1.8	-1.8
Ever depressed for a whole week	0.3	0.4	1.3	0.2	-1.2	-0.3	-0.1
Unable to work because of sickness or disability	0.6	0.8	1.9	-0.5	-0.1	-1.4	1.1
Commuting to job workplace: Cycle	0.4	0.4	0.8	-0.7	-0.9	-0.7	-0.3
Myopia	0.6	0.9	1.7	0.5	0.6	-1.3	-1.1
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.3	0.7	0.3	1.3	1.8
Cholesterol lowering medication	0.7	1.0	1.5	-1.0	-1.2	0.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.6	-0.0	-0.8	0.3	-0.2
Pain experienced in last month	0.5	0.9	1.6	0.0	-0.8	1.2	1.1
Supplements: Calcium	0.8	0.9	1.9	1.4	1.2	0.2	0.4
Basal cell carcinoma (self-reported)	0.4	0.4	1.1	1.0	0.1	0.2	0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	-0.1	-1.5	-0.8	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.9	0.3	-0.4	0.8
Heart disease (siblings)	0.4	0.4	1.3	-0.2	-1.1	0.1	0.7
Alcohol drinker status: Previous	1.1	1.3	4.8	0.0	-2.2	-0.5	-0.2
Pack years of smoking	0.1	0.2	0.4	0.6	0.5	0.4	0.3
Impedance of whole body	1.2	6.4	11.3	0.9	3.4	2.3	2.9
Leg fat mass (left)	0.6	2.4	5.0	1.5	-1.4	-2.2	0.7
Arm predicted mass (left)	0.4	2.2	4.3	2.1	-0.2	-1.7	-1.3