Hub : Genes

RGL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1530 0.0500 7.3e-04 0.009 NA 0.003 NA 0.005 5.7e-02 NA 1.7e-01 NA 1.1e-01
2 YFS Blood 0.0858 0.0174 3.3e-16 0.037 0.061 0.054 0.059 0.047 4.0e-12 3.2e-19 3.7e-17 1.1e-18 5.3e-15
3 TCGA Liver Hepatocellular Carcinoma 0.1620 0.0860 6.3e-03 -0.006 0.017 0.022 NA -0.003 7.8e-01 4.9e-02 3.2e-02 NA 5.0e-01
4 TCGA Prostate Adenocarcinoma 0.0507 0.0274 7.2e-03 -0.002 0.010 0.020 NA 0.005 6.4e-01 3.1e-02 2.9e-03 NA 9.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.2 0.8 -0.3 0.1 0.9 0.0
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 0.4 -0.3 0.1 0.1
Depressed Affect (Nagel 2018) 0.5 1.0 3.1 0.0 -0.9 -1.8 0.1
Depression (Nagel 2018) 0.4 0.6 1.4 0.5 0.0 -0.9 1.2
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.5 0.2 0.7 -0.3 -0.7
Neuroticism (Nagel 2018) 0.3 0.8 2.3 0.0 1.5 0.1 1.0
Schizophrenia (2018) 0.1 0.2 0.5 0.7 -0.4 -0.6 0.2
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 0.6 -0.8 -0.5 0.0
Worry (Nagel 2018) 1.0 2.1 3.4 0.8 1.8 1.0 1.9
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.0 0.2 -0.4 0.3
Alzheimer’s Disease (in father) 1.8 2.0 5.9 0.8 -1.1 -0.5 2.4
Alzheimer’s Disease (including proxy) 0.4 0.6 1.2 0.4 -0.6 -0.7 1.1
Crohns Disease (2017) 0.5 1.2 2.2 -0.4 -1.2 0.8 -1.5
Irritable Bowel Disease (IBD) 0.6 1.4 3.0 0.6 -1.7 -0.5 -1.4
Ulcerative Colitis (UC) 0.8 1.6 2.2 1.2 -1.3 -1.5 -0.9
Major Depression (MDD) 3.8 4.7 11.4 3.4 -0.8 -0.3 2.6
Reaction Time 1.4 2.6 6.4 -1.6 0.7 2.5 1.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.4 1.2 0.6 -0.7 -0.0
Breast Cancer 0.6 1.5 3.4 -0.4 1.4 0.6 1.9
Ovarian Cancer 0.4 0.6 1.1 0.5 -0.9 -0.2 1.1
Prostate Cancer 0.4 0.5 1.1 -0.4 -0.9 -1.0 0.1
Age at First Birth 3.2 4.6 9.6 -1.6 3.1 2.1 1.5
Bipolar Disorder (2011) 0.2 0.2 0.4 0.1 -0.5 -0.0 0.6
Body Mass Index (BMI) (2010) 0.4 0.5 1.8 0.5 -1.4 0.1 -0.3
Coronary Artery Disease (CAD) 0.5 0.6 1.8 -0.1 -0.7 1.4 -0.4
Crohns Disease (2012) 0.2 0.3 0.5 -0.3 -0.3 0.7 -0.6
Mean Putamen Volume 2.0 2.2 5.4 -2.3 1.0 1.0 -1.3
Fasting Glucose 0.5 0.6 1.3 -0.6 0.8 0.4 1.1
HbA1C 0.2 0.2 0.3 -0.5 0.6 -0.3 -0.5
HDL Cholesterol 1.0 1.6 4.6 -2.1 0.2 0.4 -1.3
LDL Cholesterol 0.6 1.0 2.1 0.2 -1.3 -1.4 0.5
Lupus 0.7 1.0 3.6 1.9 -0.2 -0.5 -0.0
Neuroticism (2016) 0.5 0.7 1.8 0.4 1.3 0.4 0.9
Primary Biliary Cirrhosis 0.3 0.4 0.7 0.5 0.2 -0.8 -0.8
Rheumatoid Arthritis 1.0 1.4 4.3 -2.1 0.1 -1.0 -0.5
Schizophrenia (2014) 0.3 0.6 1.2 1.1 -0.8 -0.7 0.3
Triglycerides 0.6 0.9 1.8 1.3 -0.0 -0.5 1.4
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.0 -0.2 -1.3 0.9 -1.4
Ulcerative Colitis 0.5 0.8 2.1 1.0 -1.5 -0.1 0.3
Blood Eosinophil Count 0.2 1.9 6.7 0.1 -1.0 -2.6 0.2
Blood Platelet Count 0.0 0.3 0.8 -0.3 -0.4 -0.9 -0.0
Blood Red Count 0.3 2.8 7.1 -2.7 -0.8 1.0 -1.6
Blood White Count 0.2 1.6 4.4 0.1 1.2 2.1 0.7
Heel T-Score 0.3 2.1 8.2 -0.1 -0.2 0.3 2.9
BMI 0.5 2.8 5.0 -0.6 -2.2 -2.2 -0.9
Height 0.8 14.7 34.7 5.9 4.8 -0.8 -0.4
Waist Hip Ratio (WHR) 0.4 1.6 4.0 -0.7 1.3 0.5 2.0
Systolic Blood Pressure 0.3 1.4 4.8 0.6 2.2 0.2 -0.4
Smoking Status 0.8 2.0 3.6 1.7 -1.9 -0.6 -1.1
Allergy or Eczema 0.1 0.4 0.6 -0.7 0.5 0.3 -0.8
Cardiovascular Disease 0.7 2.2 4.9 -1.7 0.2 -0.8 -2.2
Hypothyroidism (self reported) 0.7 1.6 2.5 0.8 1.6 1.3 1.3
Respiratory disease 0.6 1.3 3.0 -1.7 -0.7 0.3 -1.2
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.8 0.3 0.7 -1.3 0.6
Lung FEV1/FVC ratio 1.1 5.5 13.7 3.7 -1.2 -2.5 -0.7
Lung FVC 0.1 0.4 1.0 -0.2 -0.1 -1.0 -0.6
Neuroticism 0.4 1.1 2.2 0.2 1.5 -0.3 1.4
Chronotype (morning person) 1.9 4.5 14.0 0.9 -3.7 -1.6 0.6
Hair Pigment 0.1 1.8 3.6 1.9 1.5 0.2 -1.2
Tanning 0.1 1.4 5.4 0.2 -2.3 -0.2 0.5
Hand grip strength (left) 0.1 0.4 0.7 -0.4 0.6 -0.9 -0.5
Number of treatments/medications taken 0.6 1.0 2.4 -1.2 -0.4 0.2 -1.6
Average weekly spirits intake 0.5 0.7 2.2 -0.5 1.5 0.3 -0.3
Sensitivity / hurt feelings 0.3 0.5 1.1 0.0 -0.4 -1.1 0.7
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.7 -0.2 0.5 -0.8 0.4
Hearing difficulty/problems: Yes 0.2 0.3 1.2 -1.1 -0.3 0.2 -0.2
Relative age of first facial hair 0.6 1.1 2.5 -1.6 1.0 0.9 0.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.7 -0.9 -0.1 0.3 0.2
Ever used hormone-replacement therapy (HRT) 1.5 1.9 3.5 1.9 -1.7 0.7 -0.7
Ever had hysterectomy (womb removed) 2.1 2.4 5.5 1.6 -2.3 1.3 0.0
Systolic blood pressure, automated reading 0.3 0.9 1.2 1.1 0.9 1.0 0.7
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 2.6 0.1 0.8 1.6 0.4
Angina 0.1 0.2 0.3 0.1 0.5 -0.4 0.6
Medication for hormone replacement therapy 0.4 0.4 0.8 -0.1 -0.9 -0.0 -0.9
Vitamin and mineral supplements 1.3 1.7 3.5 -1.3 -1.3 -0.2 -1.9
Supplements: Zinc 3.3 3.6 6.7 2.6 -1.4 0.6 2.3
Medication: Co-codamol 3.1 3.6 11.0 0.2 -1.8 -3.3 -0.5
Medication: Metformin 0.2 0.3 0.7 -0.3 0.8 -0.8 0.0
Diabetes (father) 2.0 2.5 5.6 1.8 -0.7 0.6 2.4
Diabetes (mother) 0.3 0.4 1.3 -0.2 -0.2 1.2 0.0
Severe depression (siblings) 1.7 2.0 3.5 1.9 -1.1 -0.1 1.8
Pack years adult smoking proportion 0.0 0.1 0.1 0.3 0.2 -0.3 -0.2
Impedance of leg (right) 1.6 7.6 15.3 1.3 3.9 2.2 3.0
Leg fat-free mass (left) 0.5 2.9 4.9 1.7 -1.4 -2.2 -1.3
Trunk fat percentage 0.4 1.4 2.7 1.6 -0.3 -0.9 1.5
Hand grip strength (right) 0.4 1.1 4.4 -0.3 0.2 -2.1 0.1
Townsend deprivation index at recruitment 0.5 0.7 1.8 0.2 -0.7 -0.5 -1.4
Current tobacco smoking 1.7 2.8 4.0 2.0 -1.3 -1.7 -1.6
Average weekly fortified wine intake 0.9 1.0 1.7 1.1 1.3 0.6 1.0
Maternal smoking around birth 1.9 2.7 8.9 1.1 -3.0 -0.7 -0.3
Fed-up feelings 0.4 0.8 2.7 -0.5 1.6 -0.3 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.7 0.8 1.3 0.3 1.2
Relative age voice broke 1.1 1.7 4.3 -2.1 0.9 -1.2 -0.4
Taking other prescription medications 0.6 0.9 3.2 -0.7 -0.0 -0.1 -1.8
Age when periods started (menarche) 0.4 0.9 1.8 -1.1 0.4 1.3 0.7
Bilateral oophorectomy (both ovaries removed) 2.2 2.6 7.6 -0.3 -2.8 0.8 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.6 -0.9 1.2 -1.2 0.3
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 4.4 1.5 0.8 -2.1 0.2
Qualifications: CSEs or equivalent 1.2 1.5 4.4 0.4 -1.1 -2.1 0.5
Serious illness, injury or assault to yourself 2.1 2.6 6.6 2.6 -0.9 -1.2 1.3
High blood pressure 0.5 1.5 4.4 -0.6 0.1 -1.0 -2.1
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.6 -0.6 0.5 -0.8 -0.7
Multivitamins +/- minerals 0.5 0.7 2.2 0.4 0.1 0.6 1.5
Stomach or abdominal pain in last month 0.1 0.1 0.3 0.1 -0.3 0.2 -0.5
Supplements: Glucosamine 0.8 1.1 3.2 -0.3 1.8 1.1 0.2
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.3 1.2 -0.2 0.7 1.0
Medication: Atenolol 0.9 1.1 3.2 -0.7 0.3 -0.8 -1.8
Medication: Levothyroxine sodium 2.2 3.7 8.0 2.8 0.9 1.0 2.3
Sitting height 0.7 4.9 10.1 3.2 0.8 -0.6 -2.9
Chronic bronchitis/emphysema (father) 0.4 0.5 1.2 0.2 -1.1 -0.8 -0.3
High blood pressure (mother) 0.7 1.0 1.7 0.6 0.6 1.2 1.3
Body mass index (BMI) 0.9 3.7 8.1 0.3 -2.9 -2.5 -0.4
Impedance of leg (left) 1.4 6.6 13.6 1.2 3.7 1.6 3.0
Leg predicted mass (left) 0.6 3.0 5.0 1.6 -1.4 -2.2 -1.4
Trunk fat mass 0.4 1.7 3.5 1.9 -0.4 -1.5 0.9
Waist circumference 0.3 1.0 1.7 1.3 -0.3 -1.3 0.8
Number of incorrect matches in round 0.7 1.2 2.7 -0.1 1.5 1.6 0.1
Past tobacco smoking 0.3 0.6 1.2 0.1 1.1 0.4 1.1
Alcohol usually taken with meals 0.6 1.0 2.4 -1.1 0.7 1.6 0.2
Nervous feelings 1.4 2.6 5.3 0.5 2.3 1.4 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.3 -0.8 1.1 -0.1 1.1
Hearing difficulty/problems with background noise 0.6 1.0 3.9 -2.0 -0.1 0.3 -0.3
Hair/balding pattern: Pattern 2 0.8 1.0 2.4 0.8 0.8 0.5 1.5
Had menopause 0.7 0.8 2.0 0.8 0.8 1.4 0.2
Had other major operations 0.3 0.4 0.5 -0.2 0.7 0.6 0.7
Forced vital capacity (FVC) 0.2 0.7 0.9 0.8 1.0 -0.8 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.1 -1.4 0.5 -1.1 -0.3
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 5.0 0.9 -2.2 -1.3 -0.2
Qualifications: None of the above 0.4 0.8 1.2 0.4 -1.0 1.1 1.0
Financial difficulties in last 2 years 1.3 1.7 5.2 -0.4 -2.3 -0.9 0.8
Mouth/teeth dental problems 0.5 0.8 1.5 -0.0 -1.2 -1.2 0.5
Heart attack 0.7 0.9 2.7 -0.5 -1.6 -0.7 0.4
Allergy 0.5 1.1 1.9 1.3 0.3 0.8 1.4
Pain all over the body in last month 0.7 0.7 1.9 0.7 0.6 0.4 1.4
Diabetes (self-reported) 0.2 0.3 0.6 0.1 0.8 -0.5 -0.4
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 1.1 -1.1 0.2 0.4 -0.3
Medication: Ramipril 0.8 1.0 2.2 0.6 1.5 -0.7 -1.1
Medication: Simvastatin 0.7 1.0 2.0 -1.4 -0.0 0.9 -1.0
Fluid intelligence score 0.6 1.2 2.3 -0.8 1.2 -0.4 -1.5
Illnesses of siblings 0.0 0.1 0.1 -0.3 0.1 0.0 -0.4
Neuroticism score 0.5 1.0 1.7 -0.3 1.1 -1.1 1.3
Weight 0.5 2.5 4.9 2.2 -0.8 -2.1 -0.3
Impedance of arm (right) 1.2 5.6 7.8 1.0 2.8 2.4 2.8
Arm fat percentage (right) 0.5 1.8 3.2 0.6 -1.6 -1.8 1.0
Trunk fat-free mass 0.4 2.3 3.6 1.6 0.1 -1.7 -1.9
Hip circumference 0.4 1.6 3.8 2.0 -0.4 -1.5 0.1
Time employed in main current job 0.5 0.6 0.8 -0.2 0.9 0.9 0.8
Alcohol intake versus 10 years previously 1.1 1.7 3.5 0.2 -1.7 -1.9 0.7
Father’s age at death 1.5 2.1 4.0 0.9 2.0 0.2 1.8
Worrier / anxious feelings 0.9 1.7 4.0 -2.0 1.0 1.4 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 -0.0 0.5 0.0 0.2
Falls in the last year 0.6 0.8 1.2 1.1 -1.0 1.0 -0.1
Hair/balding pattern: Pattern 3 0.8 1.2 3.0 1.7 -0.3 -0.5 1.1
Number of live births 1.0 1.4 3.1 -0.3 -1.8 0.8 1.3
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.0 1.2 0.5 -1.4 -0.7
Pulse rate 0.4 0.6 1.4 0.9 -0.5 -1.2 -0.1
Happiness 2.4 2.9 4.0 -1.2 -2.0 -2.0 -1.5
Noisy workplace 0.9 1.2 4.1 2.0 -0.3 0.5 0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.5 5.0 -0.6 -0.0 -2.2 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.5 0.6 -0.7 -0.0 -0.0
Mouth/teeth dental problems: Dentures 0.9 1.4 3.3 1.0 -1.1 1.8 -0.6
Asthma 0.9 1.8 5.5 -2.3 0.5 -0.3 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.7 -1.2 0.0 -1.3 -0.8
Medication: Cholesterol lowering 0.3 0.4 1.7 -1.3 0.0 -0.0 -0.1
Depression (self-reported) 0.2 0.3 0.5 0.7 -0.0 0.5 0.5
Medication: Lansoprazole 0.2 0.2 0.7 -0.9 0.0 -0.3 0.4
Prospective memory result 0.2 0.2 0.7 0.8 -0.2 0.1 -0.1
Lung cancer (father) 1.0 1.2 2.2 0.8 -0.8 1.0 1.5
Illnesses of mother 0.9 1.1 3.3 0.0 1.8 -0.9 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.4 1.8 -0.1 -1.9 -1.1
Pulse wave Arterial Stiffness index 0.5 0.6 1.7 1.3 0.7 -0.3 0.0
Impedance of arm (left) 0.8 3.5 5.8 0.3 2.4 1.9 2.1
Arm fat mass (right) 0.5 1.9 4.9 1.1 -1.3 -2.2 0.3
Trunk predicted mass 0.4 2.3 3.3 1.7 -0.1 -1.7 -1.8
Standing height 0.9 9.0 20.5 3.8 4.5 0.7 -0.3
Length of working week for main job 0.4 0.5 0.7 -0.3 -0.8 0.9 0.7
Exposure to tobacco smoke at home 2.1 2.4 5.1 -1.7 -0.1 -1.3 -2.2
Breastfed as a baby 0.8 1.0 3.0 0.4 0.8 1.7 0.3
Tense / ‘highly strung’ 0.8 1.3 3.9 -0.0 2.0 -0.4 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.4 1.2 -1.0 -0.5 1.0
Hair/balding pattern: Pattern 4 0.4 1.1 2.4 -1.6 1.0 -0.1 -0.9
Birth weight of first child 1.6 2.9 5.3 -2.3 1.2 2.1 0.3
Peak expiratory flow (PEF) 0.1 0.2 0.7 -0.2 -0.9 0.3 -0.3
Pulse wave reflection index 0.2 0.3 0.7 0.9 0.5 0.1 0.0
Ever highly irritable/argumentative for 2 days 1.6 1.9 5.1 1.1 1.2 0.1 2.3
Loud music exposure frequency 0.3 0.3 0.6 0.7 -0.4 -0.6 0.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.9 -1.0 -0.1 -1.3 -1.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.3 -0.4 1.5 -0.5 0.5
Blood clot in the leg (DVT) 0.3 0.4 0.7 0.7 0.4 -0.4 0.9
Medication: Paracetamol 0.2 0.3 0.5 -0.6 -0.6 0.1 -0.7
Headache pain in last month 0.2 0.3 0.7 -0.8 0.2 0.0 0.7
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.8 0.9 -0.7 0.0 0.2
Glaucoma (self-reported) 0.5 0.6 1.4 0.4 1.2 0.9 0.3
Gout (self-reported) 1.1 1.6 5.7 -2.4 0.1 0.6 -0.4
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.2 0.8 1.8 1.0 1.3
Medication: Amlodipine 1.4 2.0 4.3 -2.1 -0.7 -0.3 -1.7
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.5 -0.7 -0.8 0.2 -1.2
Birth weight 1.7 3.7 12.9 -3.6 -0.0 0.9 -1.0
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.2 0.8 -0.5 -1.1 -0.3
High blood pressure (siblings) 0.1 0.2 0.3 -0.3 -0.4 0.5 -0.3
Forced vital capacity (FVC), Best measure 0.3 1.1 1.9 1.4 0.4 -1.2 -0.9
Body fat percentage 0.4 1.5 1.8 1.3 -0.8 -1.4 1.3
Leg fat percentage (right) 0.5 1.8 2.7 1.0 -1.6 -1.5 1.1
Arm fat-free mass (right) 0.5 2.6 4.5 1.8 -0.3 -2.1 -1.6
Exposure to tobacco smoke outside home 3.9 5.2 12.9 2.6 0.1 1.2 3.6
Comparative body size at age 10 0.3 0.9 3.5 -1.9 0.3 -0.1 0.3
Number of full brothers 0.2 0.3 0.8 -0.9 0.3 -0.4 0.4
Worry too long after embarrassment 0.8 1.4 2.4 -1.6 1.0 -0.0 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.8 -0.2 -1.3 -0.0 -0.1
Wheeze or whistling in the chest in last year 0.6 1.2 2.2 -0.2 -1.5 -1.4 -0.6
Number of children fathered 1.8 2.1 4.0 1.0 -1.8 0.1 2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.9 -1.0 0.6 0.9 0.3
Age at first live birth 0.9 1.7 4.5 -1.2 2.1 0.5 0.6
Pulse wave peak to peak time 0.4 0.5 1.7 -1.3 -0.3 0.2 -0.1
Health satisfaction 1.2 1.6 3.1 -0.6 -1.8 -0.8 -1.5
Shortness of breath walking on level ground 2.3 2.8 8.2 1.7 -2.9 -0.2 0.4
Qualifications: College or University degree 0.1 0.3 0.7 0.8 -0.5 0.2 0.4
Eye problems/disorders: None of the above 1.9 2.2 3.3 -1.1 -1.8 -1.5 -1.5
Mouth/teeth dental problems: Loose teeth 0.9 1.0 2.4 0.1 -0.2 -1.3 -1.6
Emphysema/chronic bronchitis 0.4 0.4 1.3 0.0 -0.6 0.3 -1.1
Medication for pain relief, constipation, heartburn 0.6 1.1 1.8 0.9 1.4 1.0 0.9
Neck or shoulder pain in last month 0.8 1.2 3.0 -0.7 1.7 0.8 -0.8
Medication: Blood pressure 0.1 0.2 0.6 -0.2 0.7 0.0 0.1
Angina (self-reported) 0.1 0.2 0.5 -0.1 0.4 -0.7 0.3
Migraine (self-reported) 0.7 0.8 1.6 0.1 1.2 -1.3 0.3
Medication: Ibuprofen 0.7 0.9 2.0 -1.4 0.3 -1.0 -0.7
Medication: Allopurinol 1.3 1.7 4.0 -2.0 0.8 1.4 0.2
Medication: Omeprazole 0.1 0.1 0.3 0.6 -0.4 0.3 -0.2
Medication: Seretide 50 evohaler 1.1 1.2 4.6 -0.3 -0.4 2.1 0.3
Mean time to correctly identify matches 1.3 2.5 7.0 -0.6 1.1 2.6 1.1
Heart disease (mother) 0.9 1.1 2.5 -0.9 -0.9 1.6 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 3.2 -0.2 -0.7 -1.8 -0.0
Whole body fat mass 0.4 1.7 3.6 1.6 -0.7 -1.9 0.6
Leg fat mass (right) 0.5 2.0 3.5 1.5 -1.3 -1.9 0.6
Arm predicted mass (right) 0.5 2.6 4.1 1.9 -0.3 -2.0 -1.5
Pulse rate, automated reading 0.2 0.7 1.8 1.4 0.9 0.1 0.3
Alcohol intake frequency. 2.0 4.7 18.1 0.3 -4.2 0.5 -0.6
Comparative height size at age 10 2.7 14.7 26.7 4.0 5.2 4.0 0.6
Number of full sisters 2.0 2.4 4.6 2.2 -1.1 -1.8 0.8
Suffer from ‘nerves’ 0.9 1.4 2.6 1.2 1.1 0.3 1.6
Overall health rating 0.1 0.2 0.6 0.3 -0.2 -0.8 -0.3
Chest pain or discomfort 0.4 0.6 1.6 -1.2 -0.2 0.4 0.7
Had major operations 0.8 0.9 1.5 0.8 -1.1 -0.5 1.2
Age at last live birth 0.2 0.4 0.9 -0.6 0.5 -0.0 1.0
Family relationship satisfaction 0.9 1.1 2.6 0.3 1.3 -1.6 -0.2
Leg pain on walking 2.2 2.8 4.5 1.9 2.1 1.1 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.0 0.3 0.9 -1.4 0.2
Commuting to job workplace: Car/motor vehicle 2.0 2.3 4.2 1.1 -2.1 0.1 1.9
Illness, injury, bereavement, stress in last 2 years 2.6 3.2 5.9 -1.4 2.4 1.5 -1.7
Medication: Aspirin 0.5 0.6 1.7 0.1 -1.3 -0.9 -0.0
Supplements: Vitamin C 0.3 0.3 0.7 0.8 -0.2 0.1 0.9
Knee pain experienced in last month 1.0 1.5 2.8 1.7 -0.9 -1.5 -0.5
Hypertension (Self-reported) 0.7 1.8 5.4 -0.7 -0.0 -1.2 -2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.0 -0.3 0.3 0.6 -1.0
Illnesses of father: Heart disease 0.7 1.0 2.0 -0.6 -1.4 0.5 -1.2
Illnesses of siblings: Diabetes 0.8 1.0 2.4 1.1 0.7 -1.6 0.0
Smoking status: Previous 0.2 0.2 0.6 -0.4 -0.0 0.8 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 7.3 0.5 2.7 -1.2 -0.1
Whole body fat-free mass 0.5 2.8 4.2 1.8 -0.5 -2.1 -1.8
Leg fat-free mass (right) 0.6 3.1 5.6 1.6 -1.4 -2.4 -1.6
Arm fat percentage (left) 0.6 2.3 4.9 0.4 -1.9 -2.2 0.8
Average weekly red wine intake 0.4 0.5 1.2 -0.9 1.1 0.2 -0.1
Handedness (chirality/laterality): Left-handed 0.9 1.1 1.8 -0.5 0.7 1.3 1.3
Mood swings 0.3 0.5 1.2 -0.3 0.5 -0.6 1.1
Loneliness, isolation 0.2 0.2 0.8 0.3 0.2 0.2 0.9
Long-standing illness, disability or infirmity 0.4 0.7 1.0 -1.0 -0.3 0.8 -1.0
Ever had bowel cancer screening 2.0 2.4 4.5 1.2 2.1 1.9 0.0
Diabetes diagnosed by doctor 0.6 0.9 1.6 -1.1 0.3 -1.3 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 0.1 0.3 -0.8 0.5
Friendships satisfaction 0.5 0.6 2.2 -0.0 0.2 -0.3 -1.5
Qualifications: nursing, teaching 0.3 0.5 0.9 -0.8 -1.0 0.5 -0.5
Commuting to job workplace: Walk 1.4 1.6 3.1 -1.3 1.8 0.8 -0.9
Eye problems/disorders: Cataract 1.1 1.3 2.1 -1.2 1.5 0.3 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.1 0.0 1.4 1.5 0.6
Medication for cholesterol 1.1 1.7 3.3 1.1 1.4 0.5 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.2 -1.2 1.5 0.4 -0.9
Back pain experienced in last month 0.8 1.2 3.0 -0.2 -1.2 -0.7 -1.7
Mineral and other dietary supplements 0.9 1.2 3.5 0.2 -1.9 -1.0 -0.6
Breast cancer (self-reported) 0.2 0.2 0.6 0.2 0.8 -0.3 -0.3
Asthma (self-reported) 1.2 2.4 6.2 -2.5 0.7 -0.5 -1.6
Osteoporosis (self-reported) 0.6 0.8 1.4 0.3 -1.2 -1.0 -0.9
Osteoarthritis (self-reported) 0.4 0.5 1.1 0.9 -0.0 -1.1 -0.3
Medication: Aspirin 0.3 0.4 1.0 0.2 -0.9 -1.0 0.0
Medication: Gliclazide 1.1 1.3 4.3 -2.1 0.8 -0.3 -0.3
Illnesses of father: None of the above (group 1) 0.4 0.5 1.7 -0.6 1.3 -0.2 0.0
Smoking status: Current 1.9 3.1 4.3 2.0 -1.4 -2.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.3 -0.2 -0.1 -0.2 -0.6
Whole body water mass 0.5 2.9 4.5 1.8 -0.5 -2.1 -1.9
Leg predicted mass (right) 0.6 3.2 5.7 1.6 -1.4 -2.4 -1.6
Arm fat mass (left) 0.5 2.1 5.6 1.0 -1.3 -2.4 0.3
Number of self-reported non-cancer illnesses 1.0 1.7 3.3 -1.8 -0.9 -0.9 -1.3
Average weekly champagne plus white wine intake 0.9 1.2 2.6 0.2 1.4 0.4 1.6
Miserableness 1.0 1.8 4.3 -1.1 0.1 -2.1 -1.2
Guilty feelings 1.1 1.7 2.5 -1.4 1.2 1.6 0.9
Wears glasses or contact lenses 0.6 0.7 1.8 0.6 0.6 1.4 0.0
Ever taken oral contraceptive pill 0.4 0.5 1.6 -0.2 -0.5 -1.3 0.3
Hearing aid user 0.6 0.7 2.0 -0.7 -1.4 0.2 0.5
Mother’s age at death 0.1 0.1 0.4 0.2 0.6 -0.3 0.3
Financial situation satisfaction 1.9 2.4 6.5 -1.0 -1.4 -2.5 -0.3
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.8 0.2 -0.9 0.7 0.1
Commuting to job workplace: Public transport 3.3 4.0 5.6 1.3 2.2 2.0 2.4
Eye problems/disorders: Glaucoma 0.3 0.3 0.5 0.7 0.6 0.7 0.3
Medication: Blood pressure 1.4 2.6 7.6 -0.9 -1.3 -0.6 -2.8
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.8 1.7 1.0 0.1 0.5
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.5 0.1 1.2 0.7 1.0
High cholesterol (Self-reported) 0.4 0.6 1.8 -1.3 -0.1 -0.7 -0.4
Medication: Bendroflumethiazide 0.2 0.4 1.0 -0.4 -0.4 -0.4 -1.0
Medication: Paracetamol 0.2 0.3 0.8 -0.5 -0.9 -0.1 -0.6
Medication: Lisinopril 0.4 0.6 1.7 -0.1 0.6 -0.5 1.3
Medication: Atorvastatin 0.4 0.5 1.1 -0.6 -1.1 -0.4 -0.5
Illnesses of father: High blood pressure 0.6 0.7 1.4 1.2 1.1 0.2 -0.1
Alcohol drinker status: Never 0.9 1.1 2.1 -0.7 -1.3 1.4 -0.6
Ever smoked 0.5 0.8 1.2 0.6 -1.1 -0.9 -1.0
Basal metabolic rate 0.5 3.0 5.6 1.9 -0.7 -2.4 -1.5
Leg fat percentage (left) 0.7 2.4 4.2 0.9 -1.8 -2.1 1.1
Arm fat-free mass (left) 0.5 2.4 5.6 2.4 -0.1 -1.7 -1.0
Number of operations (self-reported) 1.1 1.7 2.9 1.7 -1.3 0.6 1.3
Average weekly beer plus cider intake 2.1 3.1 4.8 2.1 1.4 -2.2 1.0
Irritability 1.3 2.2 5.1 0.9 2.3 -0.6 1.6
Risk taking 2.5 3.7 6.6 2.6 -0.1 -1.3 2.6
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.8 0.6 0.6 0.9 0.7
Fractured/broken bones in last 5 years 2.0 2.6 8.4 0.0 -1.3 -2.9 -0.2
Age started oral contraceptive pill 1.5 1.9 3.8 1.2 2.0 0.1 1.5
Diastolic blood pressure, automated reading 1.0 3.1 3.3 -1.6 -1.8 -1.8 -1.8
Ever depressed for a whole week 0.3 0.4 1.3 0.2 -1.2 -0.3 -0.1
Unable to work because of sickness or disability 0.6 0.8 1.9 -0.5 -0.1 -1.4 1.1
Commuting to job workplace: Cycle 0.4 0.4 0.8 -0.7 -0.9 -0.7 -0.3
Myopia 0.6 0.9 1.7 0.5 0.6 -1.3 -1.1
Vascular/heart problems diagnosed by doctor 0.5 1.4 3.3 0.7 0.3 1.3 1.8
Cholesterol lowering medication 0.7 1.0 1.5 -1.0 -1.2 0.3 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.6 -0.0 -0.8 0.3 -0.2
Pain experienced in last month 0.5 0.9 1.6 0.0 -0.8 1.2 1.1
Supplements: Calcium 0.8 0.9 1.9 1.4 1.2 0.2 0.4
Basal cell carcinoma (self-reported) 0.4 0.4 1.1 1.0 0.1 0.2 0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.3 -0.1 -1.5 -0.8 0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.8 0.9 0.3 -0.4 0.8
Heart disease (siblings) 0.4 0.4 1.3 -0.2 -1.1 0.1 0.7
Alcohol drinker status: Previous 1.1 1.3 4.8 0.0 -2.2 -0.5 -0.2
Pack years of smoking 0.1 0.2 0.4 0.6 0.5 0.4 0.3
Impedance of whole body 1.2 6.4 11.3 0.9 3.4 2.3 2.9
Leg fat mass (left) 0.6 2.4 5.0 1.5 -1.4 -2.2 0.7
Arm predicted mass (left) 0.4 2.2 4.3 2.1 -0.2 -1.7 -1.3