TWAS hub - SMG7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.146	0.0550	4.1e-03	0.040	NA	0.013	NA	0.016	3.1e-04	NA	2.8e-02	NA	1.6e-02
2	GTEx	Artery Tibial	0.106	0.0436	4.6e-03	0.023	NA	0.040	NA	0.042	6.0e-03	NA	4.2e-04	NA	2.8e-04
3	GTEx	Lung	0.136	0.0448	5.7e-04	0.046	NA	0.095	NA	0.078	2.0e-04	NA	9.2e-08	NA	1.3e-06
4	GTEx	Nerve Tibial	0.117	0.0403	1.3e-03	0.066	NA	0.092	NA	0.103	1.8e-05	NA	4.8e-07	NA	9.9e-08
5	GTEx	Skin Sun Exposed Lower leg	0.097	0.0380	2.0e-03	0.004	NA	0.005	NA	0.003	1.3e-01	NA	1.2e-01	NA	1.6e-01
6	GTEx	Spleen	0.322	0.1110	9.2e-03	0.062	NA	0.174	NA	0.148	1.1e-02	NA	3.1e-05	NA	1.3e-04
7	GTEx	Thyroid	0.167	0.0510	6.6e-04	0.043	NA	0.039	NA	0.016	3.1e-04	NA	5.8e-04	NA	2.0e-02
8	GTEx	Whole Blood	0.127	0.0400	2.4e-04	0.046	NA	0.065	NA	0.077	4.0e-05	NA	1.3e-06	NA	1.4e-07
9	METSIM	Adipose	0.099	0.0253	2.8e-08	0.008	0.052	0.034	0.050	0.023	2.1e-02	3.1e-08	5.8e-06	4.6e-08	2.0e-04
10	YFS	Blood	0.685	0.0306	0.0e+00	0.505	0.611	0.637	0.608	0.598	7.5e-195	8.2e-261	3.4e-280	1.2e-258	5.0e-252
11	TCGA	Kidney Renal Papillary Cell Carcinoma	0.059	0.0340	5.8e-03	0.044	0.040	0.037	NA	0.045	1.5e-03	2.5e-03	3.3e-03	NA	1.4e-03
12	TCGA	Liver Hepatocellular Carcinoma	0.109	0.0510	1.7e-03	0.080	0.028	0.054	NA	0.082	1.3e-04	1.8e-02	1.5e-03	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Knee pain experienced in last month	7.3	11.3	19.6	-3.6	-3.3	-3.8	-3.3	-2.3	-3.7	-2.4	-2.9	-3.1	-4.4	-4.1	-2.4
Reaction Time	5.1	9.7	23.9	1.3	4.5	3.0	1.8	3.0	3.9	0.3	0.9	3.5	4.9	4.3	1.5
Age at first live birth	5.0	8.8	13.2	3.5	3.0	3.6	3.6	2.7	2.8	3.0	3.6	2.5	2.7	2.5	1.1
Mean time to correctly identify matches	4.9	9.3	25.9	1.5	4.0	3.1	2.0	2.5	3.6	0.6	1.1	3.6	5.1	4.2	1.4
Lupus	4.7	7.1	33.1	-0.9	-5.8	-2.7	-1.3	2.2	-2.1	-1.1	-0.3	-0.2	-4.4	-3.5	-0.4
Age at last live birth	4.2	6.2	9.8	2.5	2.5	3.1	3.1	1.9	2.5	2.2	2.9	3.1	1.9	2.5	-0.1
Mother’s age at death	3.9	4.9	8.0	2.3	2.2	2.8	2.5	1.5	2.6	2.0	2.3	1.1	2.3	2.8	1.5
Illnesses of siblings	3.8	5.3	7.5	2.2	2.4	2.6	2.4	2.3	2.7	1.8	2.1	2.7	2.2	2.5	1.5
Medication: Aspirin	3.8	5.0	10.6	-2.1	-3.2	-1.9	-1.4	-0.8	-2.9	-2.5	-1.1	-1.3	-2.8	-3.2	-2.0
Miserableness	3.8	6.6	13.8	-2.8	-3.7	-2.7	-2.3	-1.1	-2.9	-2.3	-2.1	-1.5	-2.6	-3.5	-2.1
Ulcerative Colitis (UC)	3.7	7.0	14.7	3.8	1.9	2.4	2.3	3.0	2.2	2.7	2.5	1.3	2.4	2.8	3.4
High blood pressure (siblings)	3.7	5.4	7.1	-2.6	-2.4	-2.6	-2.3	-2.1	-2.5	-1.9	-2.2	-2.5	-2.3	-2.7	-1.7
Alcohol drinker status: Previous	3.7	4.2	7.5	-2.7	-1.9	-2.3	-2.5	-1.0	-1.9	-2.7	-2.7	-1.6	-1.5	-1.3	-1.4
Overall health rating	3.6	7.7	14.1	-2.9	-2.9	-3.2	-2.9	-2.1	-3.7	-2.5	-2.7	-1.0	-3.0	-3.8	-1.5
Mineral and other dietary supplements	3.5	4.7	8.5	2.1	2.3	2.4	2.0	2.9	2.5	1.1	2.0	1.3	2.4	2.6	1.7
Depressed Affect (Nagel 2018)	3.4	7.1	12.5	-2.9	-3.3	-2.9	-2.5	-2.2	-2.7	-2.0	-2.2	-1.6	-3.2	-3.5	-2.2
Major Depression (MDD)	3.3	4.0	8.0	-2.0	-2.8	-2.0	-1.7	-2.1	-2.4	-1.6	-1.5	-1.1	-2.3	-2.2	-1.6
Forced expiratory volume in 1-second (FEV1)	3.3	11.1	22.1	4.5	0.5	3.6	4.0	4.7	2.2	4.2	4.3	1.3	2.5	2.1	2.8
Smoking Status	3.2	7.6	11.5	-2.9	-2.8	-3.2	-3.1	-2.5	-3.1	-2.4	-2.9	-2.4	-3.4	-2.3	-1.8
Diabetes (father)	3.2	4.0	7.2	-2.4	-2.5	-2.2	-2.0	-0.6	-2.2	-2.2	-1.8	-1.0	-2.3	-2.7	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	10.0	25.3	3.9	0.2	3.3	3.7	5.0	2.7	4.1	4.0	1.0	2.0	1.8	2.3
Bipolar Disorder (2011)	3.0	2.9	6.0	1.8	1.8	1.7	1.6	2.5	2.0	0.6	1.5	1.3	1.7	2.1	1.3
Lung FVC	3.0	15.5	32.2	4.8	2.8	4.1	4.1	5.7	3.6	3.6	4.2	2.9	3.4	3.6	3.5
Hand grip strength (right)	3.0	8.2	17.7	-2.4	-3.0	-2.7	-1.9	-2.4	-2.4	-0.6	-1.4	-4.2	-3.7	-4.1	-3.2
Ulcerative Colitis	2.9	4.2	6.6	2.6	1.3	2.2	2.1	2.5	1.9	1.9	2.0	1.3	2.1	2.2	2.2
Ever used hormone-replacement therapy (HRT)	2.8	3.6	10.8	-1.1	-3.3	-2.0	-1.4	-1.1	-2.5	-1.8	-1.0	-0.2	-2.3	-2.7	-0.5
Asthma	2.8	5.5	9.5	-2.9	-1.6	-2.4	-2.3	-3.1	-2.2	-1.3	-2.3	-1.4	-2.5	-2.5	-2.9
Depression (Nagel 2018)	2.7	4.1	9.0	-2.9	-0.6	-2.2	-2.6	-1.9	-1.6	-2.2	-3.0	-1.5	-1.4	-1.7	-1.0
Triglycerides	2.7	4.4	6.8	-2.3	-2.4	-2.5	-2.4	-1.9	-2.6	-1.9	-2.3	-1.5	-1.7	-2.1	-0.8
Qualifications: CSEs or equivalent	2.7	3.5	12.9	-2.2	-2.0	-1.0	-0.7	-1.1	-1.4	-0.6	-0.7	-2.5	-2.4	-1.6	-3.6
Mouth/teeth dental problems: Dentures	2.7	4.5	10.7	-2.2	-1.3	-2.9	-3.3	-1.6	-2.3	-2.4	-3.3	0.3	-1.7	-1.2	0.5
Respiratory disease	2.6	5.8	11.6	-3.4	-0.8	-2.6	-2.8	-2.7	-2.1	-2.6	-3.1	-1.0	-2.4	-2.0	-2.2
Ever had hysterectomy (womb removed)	2.6	3.0	5.2	-2.1	-0.9	-1.9	-1.9	-1.3	-1.7	-2.3	-1.8	-0.9	-2.0	-1.7	-1.6
Forced vital capacity (FVC)	2.6	10.2	24.3	4.3	0.6	3.2	3.6	4.9	2.0	3.8	4.0	1.5	2.2	2.1	3.1
Wheeze or whistling in the chest in last year	2.6	4.6	11.0	-2.5	-1.7	-1.8	-1.7	-3.3	-2.1	-1.4	-1.8	-0.6	-2.6	-2.2	-2.8
Medication: Gliclazide	2.6	3.0	6.0	2.1	1.9	1.6	1.4	1.9	1.3	1.5	1.3	-0.5	2.1	1.8	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.5	10.0	2.4	0.6	2.8	3.0	3.2	2.5	2.4	2.9	2.0	2.2	1.7	1.0
Verbal and Numeric Reasoning (VNR)	2.5	6.1	23.9	-0.8	-4.9	-1.4	-0.2	-2.1	-2.6	0.2	0.6	0.2	-3.1	-4.0	-3.1
Asthma (self-reported)	2.5	5.0	8.4	-2.9	-1.4	-2.2	-2.2	-2.7	-2.0	-1.4	-2.3	-1.6	-2.3	-2.3	-2.8
Type 2 Diabetes (T2D) (2012)	2.4	2.8	6.6	-1.4	-1.1	-1.8	-1.7	0.5	-1.5	-2.6	-1.7	-2.5	-2.2	-0.9	-0.4
Current tobacco smoking	2.4	4.0	6.2	-1.9	-2.3	-1.9	-1.5	-1.4	-2.2	-1.6	-1.3	-2.5	-2.5	-2.4	-1.9
Nervous feelings	2.4	4.4	18.7	1.7	1.6	1.0	0.2	1.9	0.7	0.5	-0.2	2.5	3.6	2.1	4.3
Mouth/teeth dental problems	2.4	3.7	8.9	1.6	1.3	2.5	2.9	0.6	2.6	2.2	3.0	-1.0	1.0	1.2	-1.1
Forced vital capacity (FVC), Best measure	2.4	8.9	28.7	3.7	0.3	2.9	3.2	5.4	2.4	3.6	3.6	1.2	1.6	1.8	2.6
Medication: Aspirin	2.4	3.1	7.1	-1.6	-2.7	-1.5	-1.0	-0.6	-2.5	-2.1	-0.8	-0.7	-2.1	-2.6	-1.4
Smoking status: Current	2.4	3.8	7.2	-1.9	-2.1	-1.9	-1.6	-1.3	-2.1	-1.6	-1.4	-2.7	-2.3	-2.2	-1.6
Age at First Birth	2.3	3.3	7.1	1.6	2.2	1.8	1.3	1.0	1.4	1.2	1.0	2.2	2.6	2.7	1.6
Type 2 Diabetes (T2D) (2018)	2.3	4.3	11.7	-2.0	-1.2	-2.5	-2.5	-1.3	-2.2	-1.6	-2.4	-3.4	-1.8	-2.0	-0.9
Hand grip strength (left)	2.3	6.2	15.3	-2.2	-2.4	-2.6	-2.0	-2.3	-1.8	-0.4	-1.6	-3.9	-3.2	-3.1	-2.6
Fed-up feelings	2.3	4.2	7.5	-2.0	-2.4	-2.5	-2.4	-0.5	-2.7	-1.8	-2.3	-1.2	-1.7	-2.7	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	6.4	-2.0	-0.4	-2.0	-2.4	-1.8	-2.4	-1.7	-2.5	-1.2	-1.0	-1.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	7.2	-2.4	-0.8	-1.9	-2.3	-2.7	-1.3	-2.4	-2.7	-1.1	-0.2	-1.7	-1.3
Schizophrenia (2018)	2.2	4.6	12.1	2.6	1.3	3.0	3.4	0.7	1.8	2.6	3.5	0.7	0.8	1.7	-0.7
Falls in the last year	2.2	3.0	7.2	-2.0	-2.5	-1.3	-0.9	-0.4	-1.3	-1.6	-0.7	0.1	-2.5	-2.2	-2.7
Depression (self-reported)	2.1	2.5	4.7	-1.5	-1.5	-1.9	-2.0	-0.3	-2.0	-1.6	-1.9	-0.9	-2.2	-1.4	-0.4
Basal cell carcinoma (self-reported)	2.1	2.5	4.0	1.8	1.9	1.7	1.3	2.0	0.8	1.4	1.2	0.7	1.9	1.9	1.5
Taking other prescription medications	2.0	3.1	5.6	-1.6	-1.7	-1.9	-1.6	-1.1	-2.2	-1.4	-1.5	-1.8	-2.1	-2.4	-1.3
Illnesses of siblings: Diabetes	2.0	2.5	6.9	-1.4	-0.4	-1.8	-2.1	-1.2	-2.0	-1.7	-2.1	-2.6	-0.3	-0.6	-0.4
Ever had bowel cancer screening	2.0	2.4	4.8	1.6	1.6	1.3	1.0	1.1	1.3	1.7	1.0	2.2	2.0	1.9	1.3
Mean Putamen Volume	1.9	2.2	5.1	0.9	2.2	0.9	0.2	1.6	1.7	-0.5	-0.1	0.9	2.2	2.0	2.0
HDL Cholesterol	1.9	3.2	7.1	1.7	2.7	1.7	1.4	1.7	1.9	0.8	1.2	1.5	1.7	2.2	1.9
Average weekly fortified wine intake	1.9	2.3	5.1	1.3	2.2	0.8	0.1	0.4	1.1	1.0	-0.1	1.7	2.2	2.2	2.2
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	3.8	-1.7	-1.1	-1.5	-1.3	-0.9	-1.4	-1.9	-1.1	-1.5	-1.9	-1.5	-1.6
Health satisfaction	1.9	2.4	8.9	-0.9	-2.3	-1.3	-0.7	-1.6	-0.7	-0.9	-0.3	-1.2	-2.3	-3.0	-1.0
Supplements: Fish oil (including cod liver oil)	1.9	2.4	4.4	-1.7	-1.1	-1.3	-1.0	-2.1	-1.5	-0.6	-1.0	-1.6	-2.0	-1.9	-2.0
Supplements: Glucosamine	1.8	2.4	5.4	-1.3	-1.8	-1.8	-1.4	-2.3	-2.2	-0.8	-1.2	-0.2	-1.3	-2.1	-0.6
Father’s age at death	1.8	2.4	5.2	1.3	1.3	1.0	0.7	2.3	1.8	2.1	0.6	1.6	1.8	1.4	1.7
Glaucoma (self-reported)	1.8	2.1	4.8	-1.6	-0.4	-1.8	-2.0	-1.2	-1.9	-1.8	-2.2	-0.8	-0.9	-0.9	0.4
Medication: Lansoprazole	1.7	2.0	3.2	-1.8	-1.0	-1.6	-1.6	-1.1	-1.4	-1.6	-1.5	-1.0	-1.3	-1.6	-1.3
Gout (self-reported)	1.7	2.3	5.2	-2.3	-0.6	-1.6	-1.7	-0.9	-0.8	-2.0	-1.8	-1.1	-1.2	-1.6	-1.8
Chest pain or discomfort	1.7	2.5	5.8	-2.0	-0.6	-1.5	-1.8	-2.4	-1.9	-1.8	-2.1	-0.3	-1.1	-0.9	-0.8
Financial difficulties in last 2 years	1.6	2.1	7.1	-1.6	-1.7	-0.9	-0.5	-1.1	-0.5	-0.9	-0.4	-0.7	-1.7	-2.3	-2.7
Alcohol intake frequency.	1.6	3.6	7.6	-2.8	-1.9	-1.7	-1.7	-1.3	-1.2	-2.5	-1.9	-1.7	-2.1	-1.5	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	6.8	1.4	2.0	1.1	0.8	0.5	0.8	1.8	0.6	0.1	1.2	2.6	1.7
Long-standing illness, disability or infirmity	1.6	2.4	3.4	-1.7	-1.7	-1.7	-1.6	-0.9	-1.6	-1.7	-1.5	-0.6	-1.8	-1.8	-1.5
Hearing aid user	1.6	1.9	3.2	-1.8	-1.2	-1.5	-1.5	-1.1	-1.1	-1.6	-1.5	0.2	-1.7	-1.7	-0.6
Hearing difficulty/problems: Yes	1.5	2.3	4.6	-1.9	-1.2	-1.8	-1.7	-0.6	-1.6	-2.2	-1.5	-0.5	-1.8	-1.7	-0.7
Maternal smoking around birth	1.5	2.1	5.5	-1.6	-1.4	-1.2	-1.0	-0.2	-1.4	-1.5	-0.8	-1.7	-2.3	-1.2	-1.9
Fluid intelligence score	1.5	3.1	11.4	-0.1	-3.4	-0.3	0.6	-0.5	-1.8	0.2	1.1	0.2	-2.2	-2.9	-2.7
Time employed in main current job	1.5	1.7	5.4	1.1	1.7	1.2	0.8	1.1	1.2	0.6	0.5	1.3	2.3	1.5	1.3
Qualifications: College or University degree	1.5	4.6	10.0	2.7	-0.1	2.4	2.9	1.9	2.1	2.1	3.2	2.7	1.6	0.5	0.8
Arm fat percentage (left)	1.5	6.1	15.0	-3.9	-0.5	-1.9	-2.2	-2.7	-2.2	-2.0	-2.6	-2.9	-2.0	-2.0	-3.2
Bipolar Disorder or Schizophrenia	1.4	3.5	7.3	2.3	1.6	2.5	2.7	0.9	1.8	2.2	2.7	0.5	0.9	1.8	-0.1
Number of incorrect matches in round	1.4	2.3	5.3	1.3	2.1	1.2	0.8	2.3	1.9	0.6	0.6	0.3	1.9	1.3	2.2
Past tobacco smoking	1.4	2.5	4.7	1.8	0.9	1.9	2.1	1.1	1.8	1.6	2.2	0.9	1.8	1.3	0.9
Arm fat percentage (right)	1.4	5.5	13.4	-3.7	-0.5	-1.8	-2.0	-2.6	-2.0	-1.7	-2.4	-2.6	-1.9	-1.8	-3.4
Leg fat percentage (right)	1.4	5.1	16.2	-3.3	-0.1	-1.5	-1.6	-2.5	-1.5	-1.3	-2.0	-4.0	-1.8	-1.7	-3.0
Emphysema/chronic bronchitis	1.4	1.6	4.6	1.7	2.1	1.4	1.3	0.0	0.5	1.6	1.3	0.2	0.7	1.5	1.1
Medication: Allopurinol	1.4	1.9	4.2	-1.9	-0.4	-1.6	-1.9	-0.8	-0.6	-1.8	-2.0	-0.4	-0.8	-1.5	-0.8
Whole body fat mass	1.4	5.7	14.3	-3.2	-1.3	-1.9	-1.9	-2.5	-2.4	-0.9	-2.1	-3.8	-2.0	-2.4	-2.9
Arm fat mass (left)	1.4	5.9	11.2	-3.4	-1.7	-2.0	-2.0	-2.3	-2.4	-1.3	-2.1	-3.1	-2.5	-2.5	-3.0
Financial situation satisfaction	1.4	1.7	3.4	-1.8	-1.3	-1.2	-1.1	-0.5	-1.1	-0.9	-1.1	-1.2	-1.8	-1.9	-1.3
Pain experienced in last month	1.4	2.4	4.9	1.8	1.7	1.8	1.5	-0.0	1.8	1.5	1.4	0.8	1.7	2.2	1.1
Intelligence (Savage-Jansen 2018)	1.3	3.9	16.5	-0.7	-4.1	-0.7	0.3	-1.1	-1.7	-0.3	0.7	0.5	-2.2	-3.4	-2.8
Rheumatoid Arthritis	1.3	1.8	3.9	0.9	1.8	1.5	1.2	1.2	2.0	0.6	0.9	-0.2	1.7	1.9	1.1
Frequency of depressed mood in last 2 weeks	1.3	1.9	4.9	-2.2	-0.6	-1.3	-1.8	-1.1	-0.9	-1.5	-2.2	-0.8	-0.3	-1.2	-1.0
Chronic bronchitis/emphysema (father)	1.3	1.5	4.2	-1.7	-0.9	-1.2	-1.4	-2.0	-0.9	-0.7	-1.6	-0.3	-0.7	-0.7	-1.3
Medication: Ramipril	1.3	1.6	3.7	-1.5	-1.2	-1.4	-1.5	-0.0	-1.9	-1.3	-1.6	-0.7	-1.2	-1.0	-0.6
Arm fat mass (right)	1.3	5.4	10.7	-3.2	-1.6	-1.8	-1.7	-2.5	-2.3	-1.1	-1.8	-3.0	-2.3	-2.4	-3.3
Migraine (self-reported)	1.3	1.6	4.4	0.5	-1.9	0.5	1.3	0.4	-0.9	1.0	1.7	0.9	-1.0	-2.1	-1.6
Leg fat mass (right)	1.3	5.1	13.5	-3.0	-1.4	-1.7	-1.6	-2.2	-2.1	-0.9	-1.8	-3.7	-2.2	-2.4	-2.8
Pulse rate, automated reading	1.3	4.2	13.2	-1.3	-2.8	-2.1	-1.7	-2.0	-3.6	-1.3	-1.4	-0.3	-1.7	-2.9	-0.6
Average weekly red wine intake	1.3	1.9	3.2	-1.6	-0.9	-1.6	-1.5	-0.7	-1.4	-1.6	-1.4	0.1	-1.6	-1.8	-1.3
Myopia	1.3	1.9	7.8	-1.4	-0.8	-1.4	-1.4	-0.9	-1.3	0.3	-1.3	-2.8	-1.1	-0.9	-1.5
Lung FEV1/FVC ratio	1.2	6.1	12.0	3.1	0.3	3.1	3.2	2.4	1.3	3.5	3.2	1.0	2.4	2.3	1.5
Trunk fat mass	1.2	5.2	13.8	-3.0	-1.3	-1.9	-1.9	-2.1	-2.6	-0.8	-2.1	-3.7	-1.9	-2.3	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.7	-1.5	-0.3	-1.5	-1.6	-0.7	-1.3	-0.8	-1.6	-1.3	-1.2	-1.0	-0.3
Breast cancer (self-reported)	1.2	1.4	7.0	-0.3	-2.6	-0.8	-0.2	-0.5	-1.5	-0.0	0.3	0.6	-1.8	-1.4	-1.2
Illnesses of father: None of the above (group 1)	1.2	1.4	5.2	0.3	2.1	1.3	0.8	0.1	1.0	1.0	0.3	0.3	1.8	2.3	-0.1
Medication: Atorvastatin	1.2	1.5	2.9	1.4	1.1	1.7	1.6	1.2	1.3	0.3	1.6	0.3	1.0	1.7	0.1
Alcohol drinker status: Never	1.2	1.4	2.5	-1.5	-1.0	-1.3	-1.3	-1.0	-0.6	-1.1	-1.3	-0.6	-1.6	-1.5	-0.6
Leg fat percentage (left)	1.2	4.3	15.0	-3.1	0.0	-1.2	-1.4	-2.2	-1.2	-0.9	-1.8	-3.9	-1.5	-1.2	-3.0
Leg fat mass (left)	1.2	4.7	13.8	-2.9	-1.3	-1.6	-1.5	-2.0	-1.9	-0.7	-1.7	-3.7	-2.1	-2.1	-2.7
Irritable Bowel Disease (IBD)	1.1	2.6	6.2	2.3	1.0	1.4	1.3	2.5	1.6	1.8	1.5	0.7	0.9	1.4	2.0
Waist circumference	1.1	4.0	8.8	-3.0	-0.6	-1.6	-1.9	-2.3	-1.8	-1.4	-2.2	-2.6	-1.5	-1.7	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.0	-1.6	-1.0	-1.5	-1.7	-0.8	-1.4	-1.3	-1.7	-0.4	-1.3	-1.0	-0.9
Body fat percentage	1.1	4.5	11.5	-3.2	-0.2	-1.6	-1.8	-2.2	-1.9	-1.0	-2.2	-3.4	-1.4	-1.6	-2.7
Number of children fathered	1.1	1.3	3.3	1.2	1.1	1.2	1.0	1.8	0.9	1.1	0.9	0.8	0.5	1.4	1.2
Medication for pain relief, constipation, heartburn	1.1	1.8	7.6	0.6	2.8	0.9	0.4	-0.1	1.4	1.0	-0.0	-0.5	1.7	2.5	0.3
Loneliness, isolation	1.1	1.5	3.2	-1.6	-0.7	-1.4	-1.6	-0.7	-0.8	-1.8	-1.7	-0.9	-0.6	-1.5	-0.5
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.8	-1.1	-2.4	-1.0	-0.7	-0.0	-1.4	-0.5	-0.5	-0.6	-1.6	-1.6	-0.5
Medication: Paracetamol	1.1	1.7	4.0	1.4	-0.8	1.4	1.8	1.2	0.9	1.3	2.0	1.9	0.7	0.0	0.6
Diastolic blood pressure, automated reading	1.1	3.4	13.5	-1.6	-1.4	-1.5	-1.1	-1.8	-1.6	-1.2	-0.9	-3.7	-1.7	-1.6	-2.5
Unable to work because of sickness or disability	1.1	1.4	4.6	-1.2	-1.6	-1.2	-1.0	-0.3	-0.9	-0.1	-0.9	-1.0	-1.5	-2.1	-1.1
Schizophrenia (2014)	1.0	2.3	6.3	1.7	0.9	2.3	2.5	0.0	1.1	1.5	2.5	0.5	0.5	1.1	-0.7
Trunk fat percentage	1.0	3.9	10.0	-2.9	-0.3	-1.6	-1.8	-1.9	-2.1	-0.9	-2.2	-3.2	-1.3	-1.5	-2.2
Multivitamins +/- minerals	1.0	1.2	2.4	-1.2	-1.2	-0.9	-0.5	-0.6	-1.5	-0.9	-0.4	-1.0	-1.4	-1.5	-1.4
Breastfed as a baby	1.0	1.2	10.0	0.9	-0.6	-0.1	0.1	-0.5	0.1	1.7	0.4	3.2	0.2	0.2	0.5
Medication: Seretide 50 evohaler	1.0	1.1	2.3	-1.3	-1.0	-1.2	-1.4	-1.1	-1.5	-0.8	-1.5	-0.3	-0.5	0.0	-1.0
Diabetes diagnosed by doctor	1.0	1.6	4.7	-1.1	-0.5	-1.6	-1.6	-0.4	-1.2	-0.9	-1.5	-2.2	-1.2	-1.2	-0.3
Age started oral contraceptive pill	1.0	1.2	4.5	1.3	1.3	0.8	0.6	-0.2	-0.0	0.7	0.5	1.2	1.4	1.2	2.1
Primary Biliary Cirrhosis	0.9	1.3	2.6	1.6	1.1	1.4	1.4	1.4	1.0	0.9	1.5	-0.1	1.0	1.0	0.4
Heel T-Score	0.9	7.3	13.6	2.5	3.0	2.8	2.1	2.4	3.0	2.7	1.5	2.0	3.2	3.7	2.9
Average weekly spirits intake	0.9	1.1	2.7	-1.3	-1.3	-0.8	-0.9	-1.2	-1.6	-0.7	-0.9	-0.8	-0.8	-0.5	-1.0
Hip circumference	0.9	3.7	6.6	-2.4	-1.8	-1.6	-1.4	-1.3	-2.4	-0.7	-1.4	-2.6	-2.2	-2.3	-2.1
Worrier / anxious feelings	0.9	1.6	5.2	0.1	1.7	0.1	-0.7	1.5	0.3	-1.0	-1.1	0.2	1.9	1.6	2.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.5	-1.1	-1.8	-1.3	-1.1	-0.5	-1.2	-0.6	-1.0	0.4	-1.3	-1.9	-1.1
Qualifications: A levels/AS levels or equivalent	0.9	2.0	9.4	0.4	-3.1	-0.0	0.8	-0.4	-0.7	0.2	1.3	0.1	-1.1	-2.6	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.1	-0.9	-1.2	-1.3	-1.1	0.0	-0.6	-1.5	-0.9	0.5	-1.8	-1.5	0.4
Illnesses of mother	0.9	1.1	5.9	0.9	0.6	0.8	0.7	0.2	-0.2	0.9	0.7	2.4	0.7	1.5	0.9
Pulse wave Arterial Stiffness index	0.9	1.0	3.0	1.3	-0.9	0.9	1.3	-0.1	-1.1	1.7	1.6	0.0	0.4	-0.5	0.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.9	1.1	0.6	0.4	0.3	1.5	1.0	1.4	0.4	0.9	0.9	0.1	2.0
Birth weight	0.9	1.9	8.8	-0.0	3.0	1.4	1.0	-0.9	1.8	0.7	0.5	1.1	0.8	1.7	-1.3
Worry too long after embarrassment	0.9	1.5	4.2	-0.4	0.3	-1.0	-1.6	1.6	-0.1	-1.6	-1.7	-0.9	0.6	-0.1	2.1
Pulse wave peak to peak time	0.9	1.1	3.1	-1.3	0.7	-1.1	-1.6	0.1	0.9	-1.7	-1.8	-0.2	-0.5	0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.7	-1.4	-0.4	-0.7	-0.8	-0.2	-1.1	-1.1	-0.8	-1.7	-1.0	-0.4	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	4.3	0.4	1.6	-0.1	-0.7	1.6	0.5	-0.4	-0.9	0.9	1.2	2.1	2.0
Back pain experienced in last month	0.9	1.3	3.7	-1.0	-1.9	-1.1	-0.9	-0.6	-1.2	-1.4	-0.8	0.1	-1.7	-1.4	-0.7
Osteoporosis (self-reported)	0.9	1.1	3.0	-0.8	-0.4	-0.9	-0.6	-1.7	-0.1	0.6	-0.3	-0.9	-1.7	-1.2	-1.5
Number of self-reported non-cancer illnesses	0.9	1.5	5.0	-1.6	-0.5	-0.9	-0.7	-0.5	-1.1	-0.9	-0.7	-1.4	-1.4	-1.7	-2.2
Medication: Lisinopril	0.9	1.2	6.1	0.5	0.9	1.1	1.1	1.1	0.7	0.4	0.9	2.5	1.1	0.8	-0.4
Cardiovascular Disease	0.8	2.8	7.2	-1.5	-2.2	-1.2	-0.8	-0.8	-2.0	-1.1	-0.8	-1.3	-1.6	-2.7	-2.5
Body mass index (BMI)	0.8	3.4	8.9	-2.8	-1.0	-1.1	-1.1	-2.1	-1.2	-1.1	-1.3	-2.2	-1.9	-1.7	-3.0
Alcohol usually taken with meals	0.8	1.3	5.7	1.2	0.5	0.5	0.6	1.0	1.1	1.1	0.8	2.4	0.6	0.6	1.7
Qualifications: None of the above	0.8	1.7	4.7	-1.4	0.8	-1.4	-1.9	-1.6	-0.3	-1.1	-2.2	-1.7	-0.4	0.2	0.3
Allergy	0.8	1.7	7.0	1.6	-0.0	0.7	0.5	1.7	0.6	-0.3	0.6	1.2	1.9	1.4	2.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.4	1.6	-1.3	0.9	1.4	1.2	0.2	1.1	1.8	0.3	0.1	-1.0	0.6
Headache pain in last month	0.8	1.4	3.1	-1.1	-1.6	-1.3	-1.2	0.4	-1.4	-1.2	-1.3	-0.0	-0.9	-1.8	0.3
Shortness of breath walking on level ground	0.8	1.0	2.8	-1.0	-0.7	-0.5	-0.5	-1.7	-0.5	-1.6	-0.5	-0.5	-1.4	-1.0	-0.9
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.6	-0.1	1.1	-0.7	-1.2	-0.2	0.4	-1.0	-1.4	-1.0	1.4	0.5	1.6
Hypertension (Self-reported)	0.8	2.2	6.2	-1.1	-2.5	-0.9	-0.4	-0.7	-1.9	-0.5	-0.3	-0.5	-1.7	-2.3	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.7	-1.1	-0.7	-1.1	-1.3	-1.0	-1.2	-1.2	-1.3	0.0	-0.4	-0.5	-0.4
Osteoarthritis (self-reported)	0.8	1.0	3.5	-0.9	-1.4	-1.0	-0.7	-0.6	-0.8	-0.3	-0.5	-0.1	-1.7	-1.9	-0.7
Average weekly champagne plus white wine intake	0.8	1.1	2.5	0.8	1.4	1.1	1.1	0.3	1.2	1.1	0.9	1.6	1.0	1.1	-0.3
Illnesses of father: High blood pressure	0.8	0.9	2.7	0.5	-1.5	-0.6	-0.4	1.6	-1.1	-0.0	-0.1	0.6	-1.0	-1.1	1.3
Ever smoked	0.8	1.5	3.0	-1.1	-1.1	-1.5	-1.6	-0.6	-1.7	-1.0	-1.4	0.1	-1.6	-1.1	-0.7
Breast Cancer	0.7	1.6	7.1	0.2	2.7	0.8	0.2	1.2	1.7	0.5	-0.1	1.1	1.2	1.9	1.1
BMI	0.7	3.9	14.2	-2.9	-1.4	-1.0	-0.8	-1.9	-1.4	-1.3	-1.0	-1.7	-2.4	-1.9	-3.8
Hypothyroidism (self reported)	0.7	1.6	8.4	-1.0	-2.9	-1.0	-0.7	-0.7	-1.3	-0.0	-0.7	1.6	-0.4	-1.5	-0.3
Medication: Co-codamol	0.7	0.8	2.3	1.0	0.2	1.0	1.1	0.9	0.9	1.5	1.2	-0.6	0.3	0.6	-0.0
Sitting height	0.7	4.7	18.8	2.3	-4.3	-0.5	0.6	1.3	-2.2	2.5	1.6	-2.3	-1.7	-2.2	1.7
Weight	0.7	3.6	11.0	-1.8	-2.3	-1.5	-1.1	-1.1	-2.1	-0.0	-1.0	-3.3	-2.2	-2.4	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	0.9	-0.1	0.9	1.3	1.0	0.1	1.2	1.5	1.1	-0.6	-0.2	0.1
Medication: Paracetamol	0.7	1.2	3.2	1.2	-1.2	1.0	1.4	1.1	0.6	1.1	1.6	1.8	0.3	-0.2	0.4
Neck or shoulder pain in last month	0.7	1.0	2.0	1.2	0.7	1.2	1.2	1.1	0.3	0.7	1.1	0.9	1.4	0.8	1.1
Mood swings	0.7	1.3	3.7	-1.2	-1.8	-1.2	-0.9	0.1	-0.8	-0.9	-0.9	0.1	-1.1	-1.9	-1.0
Medication: Bendroflumethiazide	0.7	1.1	2.4	1.3	-0.3	1.2	1.5	1.5	0.3	0.9	1.6	1.2	0.8	0.1	0.6
Neuroticism (Nagel 2018)	0.6	1.4	4.0	-1.1	-0.9	-1.5	-1.8	-0.6	-1.5	-1.2	-2.0	0.1	0.0	-1.0	0.8
Worry (Nagel 2018)	0.6	1.3	6.1	0.7	0.4	0.2	-0.3	1.0	-0.4	-0.1	-0.6	1.1	2.4	0.9	2.5
Coronary Artery Disease (CAD)	0.6	0.8	2.2	-0.2	-1.1	-0.7	-0.8	-0.3	-1.0	-1.5	-0.8	-0.7	0.2	-0.5	1.5
Neuroticism (2016)	0.6	0.8	2.5	1.1	0.6	0.6	0.3	1.2	0.9	0.6	0.2	0.7	1.6	0.8	1.2
Height	0.6	11.8	40.8	-0.1	-5.9	-3.0	-2.0	-0.3	-5.0	1.7	-1.0	-6.4	-2.2	-4.2	1.3
Waist Hip Ratio (WHR)	0.6	2.6	7.5	-2.0	1.4	-1.3	-2.2	-1.6	-0.3	-2.3	-2.7	-1.8	0.5	0.3	-0.2
Medication for hormone replacement therapy	0.6	0.7	2.7	-0.2	-1.6	-0.3	0.1	-0.0	-1.0	-0.2	0.3	0.4	-1.0	-1.0	-1.4
Diabetes (mother)	0.6	0.8	2.3	-0.9	0.6	-0.6	-0.9	-1.0	-0.5	-1.4	-1.1	-1.5	0.4	-0.4	-0.3
Relative age voice broke	0.6	1.0	4.3	-0.2	1.5	0.3	-0.2	0.2	2.1	-0.2	-0.5	-0.8	1.7	1.2	-0.1
High blood pressure	0.6	1.6	5.3	-1.0	-2.3	-0.8	-0.4	-0.4	-1.7	-0.5	-0.4	-0.1	-1.4	-2.0	-1.6
Medication: Levothyroxine sodium	0.6	1.0	2.3	-1.1	-0.9	-1.1	-1.3	-0.9	-1.5	0.5	-1.5	0.8	0.1	0.0	0.3
Happiness	0.6	0.8	2.2	-0.9	-1.1	-0.8	-0.7	-1.1	-0.1	-0.7	-0.6	-0.8	-0.9	-1.5	-0.6
Prospective memory result	0.6	0.7	3.6	0.4	0.9	-0.2	-0.6	-1.2	-0.3	0.1	-0.6	0.6	0.7	1.0	1.9
Lung cancer (father)	0.6	0.6	1.9	-1.2	-0.3	-0.5	-0.5	-1.3	-0.5	-0.8	-0.5	0.7	-0.7	-0.3	-1.4
Medication: Amlodipine	0.6	0.8	1.3	-0.8	-1.0	-0.7	-0.5	-1.0	-0.9	-0.9	-0.5	-1.0	-1.2	-1.1	-0.9
Number of full brothers	0.6	0.8	2.9	0.8	1.7	0.9	0.6	0.2	0.7	0.6	0.4	-0.4	1.2	1.4	0.5
Comparative height size at age 10	0.6	3.0	12.7	2.9	-1.2	0.2	0.7	2.2	-0.9	2.1	1.3	-0.7	1.2	-0.3	3.6
Suffer from ‘nerves’	0.6	0.9	3.9	-0.1	-0.5	-0.7	-0.9	0.1	-1.4	-0.6	-0.9	1.1	0.9	-0.6	2.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	-1.4	0.3	-0.6	-0.5	1.1	-0.4	-1.3	-0.6	-0.8	-0.9	-0.8	-0.6
Illnesses of father: Heart disease	0.6	0.9	3.2	0.3	-1.4	-0.3	0.5	0.3	0.0	0.2	1.0	-0.6	-1.5	-1.8	-0.9
Smoking status: Previous	0.6	0.9	2.1	-0.9	-0.3	-1.2	-1.4	-0.8	-1.3	-0.8	-1.5	0.3	-0.8	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	5.0	0.1	-1.4	-1.0	-0.9	0.6	-1.1	0.7	-0.7	-2.2	-0.0	-1.1	1.3
Number of operations (self-reported)	0.6	0.9	3.4	-0.5	-1.8	-0.8	-0.7	1.1	-0.7	-0.1	-0.4	0.9	-1.5	-0.8	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.9	-0.2	-0.9	-1.2	-0.6	-0.5	-0.6	-1.3	-1.3	-0.2	0.1	-0.4
Alzheimer’s Disease (in father)	0.5	0.6	1.9	0.7	1.0	0.5	0.5	1.0	0.7	0.8	0.4	0.5	0.5	0.6	1.4
LDL Cholesterol	0.5	0.8	2.6	-1.0	0.3	-0.4	-0.6	-1.6	-0.2	-0.8	-0.7	-1.2	-0.5	0.7	-1.3
Blood Platelet Count	0.5	6.2	13.3	-3.5	1.2	-2.6	-3.2	-3.1	-1.8	-2.5	-3.6	-1.4	-1.8	-0.3	-2.4
Number of treatments/medications taken	0.5	1.0	2.6	-0.9	-1.5	-0.7	-0.4	0.0	-1.3	-1.3	-0.4	-0.1	-1.1	-1.6	-0.9
Sensitivity / hurt feelings	0.5	0.8	2.5	-0.8	0.1	-1.2	-1.5	-0.1	-0.7	-1.5	-1.6	-0.1	-0.5	-0.4	0.3
Vitamin and mineral supplements	0.5	0.6	2.6	0.5	1.0	0.7	0.5	-0.1	1.6	0.1	0.5	0.7	0.9	1.1	-0.2
Leg fat-free mass (left)	0.5	2.7	7.3	-0.9	-2.4	-1.2	-0.7	-1.0	-1.9	0.2	-0.3	-2.7	-2.3	-2.4	-1.1
Stomach or abdominal pain in last month	0.5	0.7	2.5	0.6	-1.1	-0.0	0.2	0.3	-1.0	0.1	0.3	1.6	0.1	-1.0	1.3
Leg predicted mass (left)	0.5	2.7	6.9	-0.8	-2.5	-1.2	-0.7	-0.9	-1.8	0.3	-0.2	-2.6	-2.3	-2.4	-1.2
Had menopause	0.5	0.6	1.1	0.9	0.7	0.8	0.8	0.8	0.1	0.5	0.8	0.7	1.1	0.9	0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	3.8	-0.3	-1.0	0.4	0.6	-0.1	0.7	0.5	0.7	0.5	-0.4	-0.7	-1.9
Pain all over the body in last month	0.5	0.5	1.7	-0.1	1.3	0.8	0.6	-0.4	0.6	0.3	0.4	0.3	1.3	0.4	-0.8
Tense / ‘highly strung’	0.5	0.9	3.8	1.1	0.3	0.3	-0.0	0.6	0.0	1.2	-0.1	-0.2	1.8	0.6	2.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.4	-0.4	-1.0	-0.6	-0.6	-0.9	-1.5	-0.6	-0.7	0.3	0.0	-1.5	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	1.1	0.7	1.1	1.1	-0.3	0.2	0.8	1.2	0.9	0.4	0.6	0.0
Arm fat-free mass (right)	0.5	2.4	8.5	-0.0	-2.9	-0.6	0.1	-0.1	-1.2	1.2	0.6	-2.6	-1.9	-2.2	-0.7
Heart disease (mother)	0.5	0.7	2.4	-0.7	-1.0	-0.5	-0.1	-0.7	-0.4	-0.2	0.1	-0.8	-0.7	-1.5	-1.4
Arm predicted mass (right)	0.5	2.6	8.8	-0.2	-3.0	-0.8	-0.1	-0.1	-1.4	0.9	0.5	-2.9	-2.1	-2.4	-0.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	0.1	1.0	0.9	0.7	1.1	1.0	0.7	0.5	0.9	0.6	1.0	-0.4
Medication for cholesterol	0.5	0.7	1.8	-0.0	1.1	-0.4	-0.9	-0.9	0.2	0.5	-0.9	1.2	0.4	1.4	1.0
Wears glasses or contact lenses	0.5	0.6	1.5	-0.2	-1.0	-0.7	-0.4	-1.2	-0.9	0.2	-0.1	0.8	-1.1	-1.0	-0.9
Eye problems/disorders: Glaucoma	0.5	0.5	1.5	-0.7	0.1	-0.7	-1.0	-0.7	-1.0	-1.0	-1.2	-0.4	0.1	-0.1	0.6
Basal metabolic rate	0.5	2.9	9.9	-0.7	-2.8	-1.1	-0.5	-0.6	-1.7	0.6	-0.0	-3.1	-2.3	-2.4	-1.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.5	1.0	1.7	0.6	0.4	0.5	1.7	1.0	0.4	0.2	1.2	1.9	1.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	0.5	0.2	1.2	1.3	1.1	0.8	0.4	1.2	-0.4	0.6	0.4	-0.0
Arm predicted mass (left)	0.5	2.6	8.8	-0.1	-3.0	-0.8	-0.1	-0.2	-1.3	1.2	0.6	-2.7	-2.2	-2.3	-0.9
Fasting Glucose	0.4	0.4	1.4	-0.1	1.2	0.1	-0.2	0.6	0.1	-0.0	-0.3	0.7	0.9	1.0	1.0
HbA1C	0.4	0.4	2.6	-0.1	-0.6	0.1	0.3	-0.5	-0.6	0.1	0.4	1.6	-0.4	-0.8	-0.1
Neuroticism	0.4	0.9	2.0	-0.6	-0.8	-0.9	-1.2	-0.2	-1.3	-0.9	-1.4	0.9	0.5	-0.9	0.9
Chronotype (morning person)	0.4	1.0	2.8	-0.2	-1.6	-0.5	0.1	-0.6	-0.3	-0.5	0.5	-1.4	-1.4	-1.3	-1.7
Systolic blood pressure, automated reading	0.4	1.2	2.3	-1.4	-1.1	-1.5	-1.5	-0.9	-1.3	-0.6	-1.5	-0.7	-0.6	-0.4	-0.3
Age when periods started (menarche)	0.4	1.0	3.4	-1.8	0.8	-0.2	-0.9	-1.4	-0.5	-1.0	-1.6	0.1	-0.2	0.9	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	-0.1	0.3	0.8	0.6	0.6	1.1	0.2	0.3	0.2	0.9	0.5	-1.0
Medication: Atenolol	0.4	0.5	1.7	0.8	-0.6	0.8	1.1	0.1	0.0	0.2	1.3	0.4	-0.7	-0.4	-0.6
Had other major operations	0.4	0.5	1.4	-1.2	-0.6	-0.7	-0.8	0.6	-0.2	-0.1	-1.0	0.5	-0.9	-0.8	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	3.3	-0.3	0.4	0.4	0.6	-0.1	0.0	0.3	0.6	-1.2	-0.6	-0.4	-1.8
Medication: Simvastatin	0.4	0.6	1.8	-0.8	-0.4	-0.3	-0.2	-0.0	-0.8	-1.4	-0.3	-1.0	-0.1	-1.3	-0.9
Trunk fat-free mass	0.4	2.2	7.7	0.2	-2.8	-0.8	-0.1	-0.1	-1.3	1.1	0.5	-2.6	-2.0	-2.0	-0.4
Number of live births	0.4	0.5	2.7	-1.0	0.4	0.3	0.3	-0.1	1.0	-1.0	0.2	0.2	-0.1	0.3	-1.6
Pulse rate	0.4	0.6	2.1	0.8	-1.4	-0.1	0.3	-0.8	-0.8	0.9	0.7	-0.1	-0.3	-1.5	0.3
Trunk predicted mass	0.4	2.2	7.6	0.1	-2.8	-0.8	-0.1	-0.1	-1.2	1.0	0.6	-2.7	-2.0	-2.1	-0.5
Standing height	0.4	3.6	8.6	1.6	-2.8	-1.0	-0.4	2.0	-2.2	2.2	0.4	-2.9	-0.9	-1.8	2.3
Birth weight of first child	0.4	0.7	2.6	-0.9	1.1	-0.6	-0.9	-1.6	-0.3	-0.9	-1.1	-0.3	0.2	-0.4	-0.4
Loud music exposure frequency	0.4	0.4	2.6	-0.8	-0.0	-0.1	-0.1	-0.3	-0.4	0.5	-0.2	-1.6	-0.7	-0.5	-0.9
Blood clot in the leg (DVT)	0.4	0.5	1.4	0.4	0.0	1.0	1.2	1.0	0.8	0.5	1.1	-0.5	0.5	0.2	-0.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	3.4	-0.5	-0.8	-0.5	-0.4	-0.0	-0.4	0.6	-0.4	-1.8	-0.4	-0.6	-0.3
Comparative body size at age 10	0.4	1.0	3.9	-0.0	2.0	0.5	-0.0	0.2	1.4	-0.4	-0.4	0.7	1.7	1.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.7	-0.3	-1.0	-0.5	-0.5	-0.8	-1.0	-0.5	-0.5	-0.3	-1.3	-0.7	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.0	-0.3	-1.4	-0.4	-0.1	0.4	-1.1	-0.6	0.1	0.4	-1.0	-0.6	-0.5
Number of full sisters	0.4	0.4	1.9	-0.1	-1.3	-0.1	0.1	-1.1	-1.4	0.4	0.1	0.4	-0.4	-0.2	-0.2
Leg pain on walking	0.4	0.5	1.6	-0.8	0.0	-1.1	-1.3	-0.7	-0.0	-0.1	-1.3	-0.4	-0.3	-0.5	0.1
Supplements: Vitamin C	0.4	0.5	2.4	0.3	-1.5	0.1	0.3	-0.6	-1.3	0.3	0.3	0.9	-0.1	-0.1	0.3
Whole body fat-free mass	0.4	2.3	7.0	-0.1	-2.6	-0.8	-0.2	-0.2	-1.4	1.0	0.4	-2.6	-2.0	-2.1	-0.6
Leg fat-free mass (right)	0.4	2.1	5.9	-0.5	-2.4	-1.0	-0.5	-0.5	-1.6	0.5	0.0	-2.4	-2.1	-2.0	-1.0
Commuting to job workplace: Walk	0.4	0.5	1.7	-0.0	-1.0	-0.9	-0.9	-1.3	-0.7	0.2	-0.8	-0.2	0.3	-0.3	-0.1
Eye problems/disorders: Cataract	0.4	0.5	1.3	0.1	-0.3	0.5	0.9	0.9	0.8	0.5	1.1	0.0	-0.5	-0.7	-0.8
Whole body water mass	0.4	2.4	7.7	-0.0	-2.8	-0.8	-0.1	-0.3	-1.4	1.0	0.5	-2.6	-2.1	-2.2	-0.8
Leg predicted mass (right)	0.4	2.1	5.9	-0.5	-2.4	-1.0	-0.5	-0.5	-1.7	0.6	0.0	-2.3	-2.1	-2.0	-1.0
Guilty feelings	0.4	0.6	3.5	-0.5	0.2	0.1	-0.3	0.8	0.1	-0.5	-0.7	1.9	1.1	0.4	0.7
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.4	0.5	-0.1	0.8	1.0	0.0	1.2	0.3	1.1	0.4	0.1	-0.3	-0.1
Commuting to job workplace: Public transport	0.4	0.5	3.8	0.4	-0.2	-0.3	-0.4	0.1	-0.0	0.1	-0.4	1.9	0.8	-0.1	0.8
Medication: Blood pressure	0.4	0.8	2.3	0.6	-1.3	0.9	1.4	0.8	0.2	-0.0	1.5	-0.7	0.1	-1.1	-0.6
Arm fat-free mass (left)	0.4	2.1	7.4	0.1	-2.7	-0.5	0.2	0.1	-1.1	1.5	0.8	-2.5	-1.9	-1.9	-0.8
Irritability	0.4	0.7	2.3	-0.1	-1.5	-0.7	-0.5	0.2	-1.4	-0.0	-0.4	0.8	-0.3	-1.5	0.0
Fractured/broken bones in last 5 years	0.4	0.5	1.3	0.6	1.1	1.0	0.9	-0.4	1.1	0.8	0.9	0.3	0.2	0.4	-0.1
Cholesterol lowering medication	0.4	0.6	3.0	-0.6	-0.6	0.2	0.3	0.8	-0.4	-1.7	0.3	-1.4	-0.6	-0.8	-0.5
Supplements: Calcium	0.4	0.4	2.7	0.9	-0.4	-0.6	-0.5	0.5	-0.5	0.4	-0.2	-0.0	-0.1	0.2	1.6
Heart disease (siblings)	0.4	0.5	1.9	0.6	1.4	0.6	0.4	-0.7	0.4	-0.0	0.4	-0.8	0.6	1.2	0.6
Prostate Cancer	0.3	0.4	1.7	-0.8	-0.1	-0.3	-0.4	0.9	-0.6	-1.3	-0.5	0.1	-0.3	-0.4	-0.4
Crohns Disease (2012)	0.3	0.5	2.2	-1.1	-0.0	-0.6	-0.7	-0.0	-0.2	-0.6	-0.9	-1.5	-0.5	-0.3	-0.5
Blood Red Count	0.3	2.5	9.1	1.1	-0.3	2.1	2.8	1.7	1.2	0.1	3.0	0.1	1.0	-0.4	-1.3
Relative age of first facial hair	0.3	0.6	1.7	-0.7	0.9	0.2	-0.2	0.1	1.1	-1.1	-0.6	-0.7	0.5	0.8	-1.3
Medication: Metformin	0.3	0.5	1.8	0.6	0.2	0.4	0.1	1.3	-0.6	0.3	-0.0	-0.1	0.8	0.6	1.3
Pack years adult smoking proportion	0.3	0.4	1.2	-0.4	-0.8	-0.7	-0.7	-0.9	-1.1	-0.3	-0.6	0.5	-0.4	-0.5	-0.2
Townsend deprivation index at recruitment	0.3	0.4	1.6	0.1	-1.0	-0.2	0.2	0.4	-1.3	-0.5	0.4	0.5	-0.5	-0.7	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	-0.7	0.6	-0.5	-0.5	-0.9	0.1	0.7	-0.5	-1.1	-1.2	-0.5	-1.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.1	0.6	-0.7	0.0	0.0	-0.4	-0.9	0.0	0.1	1.0	0.3	-0.4	1.0
Neuroticism score	0.3	0.7	1.2	-0.4	-1.0	-0.8	-1.0	0.7	-1.1	-0.8	-1.1	0.4	0.4	-1.0	0.9
Alcohol intake versus 10 years previously	0.3	0.4	1.9	-0.7	-0.4	0.0	-0.1	-1.4	-0.9	-0.7	-0.2	-0.1	0.1	-0.5	-0.9
Hair/balding pattern: Pattern 3	0.3	0.5	1.5	-0.6	0.6	-0.8	-0.9	-0.7	0.1	-1.2	-0.8	-0.5	-0.5	-0.2	0.1
Hair/balding pattern: Pattern 4	0.3	0.6	3.0	0.3	0.0	-0.2	-0.1	1.6	0.5	0.3	0.0	-1.7	0.3	-0.1	1.2
Pulse wave reflection index	0.3	0.3	1.6	-0.1	-0.2	-0.5	-0.4	-0.6	-1.2	0.3	-0.3	-0.9	-0.6	-0.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.4	-0.9	-1.2	-0.8	-1.0	-0.8	-1.1	-0.4	-1.1	0.7	0.4	-0.3	0.2
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-0.3	0.2	-0.5	-0.6	-0.9	-0.9	-1.0	-0.6	0.6	0.4	-0.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	2.2	0.3	-0.0	0.1	0.1	0.8	1.0	-0.1	0.1	1.5	0.3	0.5	0.4
Medication: Ibuprofen	0.3	0.3	1.1	-0.5	-0.4	-0.4	-0.4	0.1	-0.3	-0.7	-0.3	1.0	-0.8	-0.8	0.4
Friendships satisfaction	0.3	0.3	2.2	0.1	0.2	-0.2	-0.2	0.5	0.1	0.6	-0.1	-1.5	-0.6	-0.3	0.5
Qualifications: nursing, teaching	0.3	0.5	1.6	0.4	-0.4	0.6	1.0	0.5	0.6	0.4	1.1	0.7	0.1	-0.8	-1.3
High cholesterol (Self-reported)	0.3	0.5	2.5	-0.3	0.6	0.9	0.7	-0.1	0.2	-0.1	0.5	-0.8	1.1	0.2	-1.6
Average weekly beer plus cider intake	0.3	0.4	1.1	0.4	-1.1	0.2	0.6	0.7	-0.1	1.0	0.8	0.2	-0.5	-0.6	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	-0.4	-0.7	-0.7	-0.7	-0.4	0.1	0.5	-0.6	0.5	-0.7	-0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.7	0.6	0.1	0.4	0.4	1.3	0.4	-0.1	0.6	1.0	0.3	0.2	0.9
Bipolar Disorder (2018)	0.2	0.3	0.9	0.5	0.9	0.3	0.1	0.6	0.8	0.4	-0.0	-0.0	0.5	0.8	0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	1.0	0.5	-0.4	0.8	0.9	-0.2	-0.1	0.3	1.0	0.5	-0.2	0.1	-0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	-0.1	0.8	-0.1	-0.4	0.5	0.4	0.1	-0.5	-1.1	0.2	0.7	0.5
Ovarian Cancer	0.2	0.3	1.2	-0.6	-0.1	-0.3	-0.3	-1.1	-0.1	-0.1	-0.3	0.1	-0.9	0.1	-0.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.4	-0.4	0.6	0.8	0.3	0.5	0.6	0.9	0.7	-0.1	-0.1	-0.8
Blood White Count	0.2	1.3	6.1	0.4	-2.4	-0.1	-0.0	0.1	-1.2	-0.5	0.0	2.5	0.9	-0.5	1.0
Allergy or Eczema	0.2	0.5	3.3	-0.4	1.8	-0.0	-0.3	-0.1	0.5	1.1	-0.5	-0.5	-0.5	0.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.7	-0.4	0.1	-0.0	-0.1	1.3	1.0	-0.3	-0.3	-0.0	0.1	-0.6	-0.0
Angina	0.2	0.2	1.4	0.2	0.7	0.3	0.2	-0.1	-0.4	-0.8	0.1	1.2	0.1	0.1	0.3
Severe depression (siblings)	0.2	0.2	1.0	-0.6	-0.4	-0.3	-0.1	-0.5	0.3	0.1	0.0	0.0	-0.3	-0.9	-1.0
Impedance of leg (right)	0.2	1.0	2.6	0.5	1.6	0.2	-0.1	1.0	0.3	0.7	-0.4	-1.1	1.5	1.0	1.6
Serious illness, injury or assault to yourself	0.2	0.3	0.9	0.7	-0.5	0.4	0.6	0.7	-0.2	0.2	0.7	0.9	-0.4	-0.2	0.5
High blood pressure (mother)	0.2	0.2	1.0	0.2	0.1	-0.2	-0.1	0.7	0.5	0.1	-0.0	-1.0	0.1	-0.9	0.4
Impedance of leg (left)	0.2	1.2	2.7	0.6	1.6	0.4	-0.1	1.3	0.4	1.0	-0.4	-1.0	1.6	1.4	1.5
Hair/balding pattern: Pattern 2	0.2	0.2	1.0	-0.1	-1.0	-0.3	-0.2	-0.2	-0.7	0.5	-0.2	0.1	0.2	-0.8	-0.5
Heart attack	0.2	0.3	1.3	-0.1	0.8	-0.0	-0.1	-1.1	-0.2	-1.1	-0.2	-0.5	-0.3	-0.1	-0.3
Diabetes (self-reported)	0.2	0.3	1.5	-0.0	-0.3	-0.6	-0.6	0.4	-0.7	0.4	-0.4	-1.2	-0.5	-0.6	-0.1
Impedance of arm (right)	0.2	0.8	3.4	-0.2	1.8	-0.5	-1.0	0.2	-0.3	-0.3	-1.3	0.2	1.1	0.8	0.9
Noisy workplace	0.2	0.3	1.0	0.4	-0.5	0.5	0.6	1.0	0.2	0.4	0.5	-0.8	0.2	0.1	0.6
Impedance of arm (left)	0.2	1.0	3.2	-0.6	1.8	-0.8	-1.4	0.1	-0.6	-0.8	-1.8	-0.1	0.9	0.4	1.1
Length of working week for main job	0.2	0.2	0.9	-0.5	0.3	-0.2	-0.3	0.3	-0.8	-1.0	-0.4	-0.4	-0.3	0.1	0.2
Exposure to tobacco smoke at home	0.2	0.2	0.9	1.0	-0.3	0.4	0.5	-0.2	-0.3	0.1	0.7	0.6	0.2	0.1	0.6
Peak expiratory flow (PEF)	0.2	0.5	1.3	0.6	-0.3	0.4	0.8	0.6	-0.0	0.9	1.1	-1.1	-0.4	-0.7	-0.2
Medication: Blood pressure	0.2	0.3	1.2	-0.3	-0.5	-0.3	-0.3	0.0	-1.1	-1.1	-0.4	0.8	-0.4	-0.3	-0.4
Angina (self-reported)	0.2	0.2	0.9	0.1	0.9	0.3	0.2	-0.1	-0.2	-0.9	0.0	1.0	0.1	0.1	0.1
Family relationship satisfaction	0.2	0.3	1.0	0.2	-0.8	-0.1	-0.1	0.6	-0.5	1.0	-0.1	-0.1	0.3	-0.5	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.2	0.2	0.1	-0.1	-0.2	0.1	-1.1	0.1	-0.1	-0.1	0.3	0.2	1.1
Risk taking	0.2	0.3	1.0	-1.0	-0.5	-0.2	-0.3	0.3	-0.7	-0.5	-0.4	0.1	-0.9	-0.5	-0.5
Commuting to job workplace: Cycle	0.2	0.3	1.2	0.0	-0.6	0.2	0.4	-0.6	0.1	-0.1	0.5	0.4	-0.8	-0.0	-1.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.0	-0.1	0.6	-0.0	-0.1	-0.9	-0.3	-1.0	-0.1	-0.5	-0.5	-0.0	-0.2
Impedance of whole body	0.2	0.8	2.2	-0.1	1.5	-0.4	-0.9	0.8	-0.3	-0.0	-1.2	-0.2	1.2	0.8	1.4
Crohns Disease (2017)	0.1	0.3	0.8	-0.2	-0.2	-0.2	-0.1	0.9	0.7	0.3	-0.0	-0.6	-0.9	-0.5	-0.3
Blood Eosinophil Count	0.1	0.6	1.5	-0.3	1.2	1.1	0.7	-1.2	1.0	0.2	0.3	-0.1	0.6	0.6	-0.6
Systolic Blood Pressure	0.1	0.4	1.2	-0.2	-1.1	-0.9	-0.9	0.7	-0.8	-0.2	-0.8	-0.6	0.3	-0.2	0.4
Tanning	0.1	1.8	5.2	-1.3	-0.6	-1.5	-1.5	-2.3	-1.2	-0.8	-1.4	-1.0	-1.4	-1.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.5	-0.3	0.3	-0.6	-0.6	-0.1	0.3	-0.3	-0.7	0.2	-0.2	-0.4	0.2
Supplements: Zinc	0.1	0.1	0.9	0.1	-0.3	-0.3	-0.1	-0.9	-0.6	-0.1	-0.1	0.4	-0.3	-0.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.1	-0.6	0.0	0.0	0.0	0.3	-0.2	0.7	-0.1	-1.1	-0.4	0.2	-0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.7	0.2	-0.1	-0.4	-0.1	-0.2	-0.7	-0.6	0.6	-0.7	0.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	-0.3	-0.1	0.5	0.5	0.7	0.4	0.7	0.2	-1.0	0.3	0.8	-0.7
Medication: Cholesterol lowering	0.1	0.2	0.9	0.2	0.9	0.4	0.3	-0.2	-0.0	-0.4	0.2	-0.2	0.8	0.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	0.0	0.2	-0.1	-0.2	-0.0	0.5	0.5	-0.2	-0.4	-0.0	0.4	0.5
Eye problems/disorders: None of the above	0.1	0.2	0.5	0.7	0.3	0.2	0.2	0.1	-0.2	0.0	0.2	-0.3	0.4	0.7	0.7
Medication: Omeprazole	0.1	0.2	1.0	0.5	-0.1	0.2	0.3	0.3	-0.0	-0.1	0.5	1.0	0.2	0.0	0.6
Had major operations	0.1	0.1	0.6	0.1	0.0	0.1	0.1	0.8	0.5	0.1	0.1	-0.1	0.0	-0.6	-0.3
Ever taken oral contraceptive pill	0.1	0.2	1.0	0.5	-0.3	-0.0	0.0	1.0	-0.0	0.5	0.2	0.2	-0.5	-0.1	0.3
Ever depressed for a whole week	0.1	0.2	0.5	0.0	-0.6	0.4	0.4	0.1	0.5	0.3	0.3	0.7	0.2	-0.1	-0.6
Pack years of smoking	0.1	0.2	0.8	-0.1	-0.4	-0.4	-0.4	-0.5	-0.8	-0.1	-0.4	0.9	0.2	-0.0	0.2
Hair Pigment	0.0	0.2	1.5	0.2	-0.6	-0.2	0.0	0.2	0.7	1.2	0.2	-0.1	-0.5	-0.0	-0.3

Hub : Genes

SMG7

Models

Trait associations