Hub : Genes

NCF2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.2106	0.0455	2.4e-12	0.131	NA	0.138	NA	0.084	1.8e-10	NA	6.5e-11	NA	3.8e-07
2	GTEx	Muscle Skeletal	0.0631	0.0292	3.8e-03	0.020	NA	0.025	NA	0.017	4.0e-03	NA	1.4e-03	NA	7.3e-03
3	GTEx	Nerve Tibial	0.1352	0.0461	1.0e-04	0.000	NA	-0.001	NA	-0.001	3.2e-01	NA	3.9e-01	NA	3.6e-01
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1280	0.0550	2.7e-03	0.171	NA	0.133	NA	0.166	1.2e-09	NA	9.1e-08	NA	2.1e-09
5	GTEx	Skin Sun Exposed Lower leg	0.1990	0.0590	2.3e-05	0.138	NA	0.152	NA	0.164	1.6e-11	NA	1.4e-12	NA	1.7e-13
6	GTEx	Uterus	0.4900	0.1050	1.8e-04	0.019	NA	0.064	NA	0.015	1.3e-01	NA	2.0e-02	NA	1.6e-01
7	NTR	Blood	0.0249	0.0097	5.9e-04	0.011	0.006	0.005	0.008	0.004	1.4e-04	4.4e-03	5.6e-03	1.3e-03	1.5e-02
8	YFS	Blood	0.0453	0.0133	4.2e-07	0.025	0.024	0.029	0.029	0.024	8.4e-09	2.3e-08	8.3e-10	5.6e-10	2.4e-08
9	TCGA	Pancreatic Adenocarcinoma	0.2300	0.1030	6.1e-03	0.008	0.042	0.057	NA	0.012	1.4e-01	7.6e-03	2.0e-03	NA	1.0e-01
10	TCGA	Prostate Adenocarcinoma	0.0510	0.0261	1.3e-03	0.035	0.034	0.028	NA	0.027	1.2e-04	1.6e-04	5.3e-04	NA	6.6e-04
11	TCGA	Rectum Adenocarcinoma	0.3400	0.1440	3.2e-03	0.055	0.069	0.042	NA	0.037	2.1e-02	1.1e-02	3.7e-02	NA	4.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.8	1.9	-1.3	0.3	-0.6	-1.2	-1.4	0.8	0.7	0.2	-1.4	0.1	0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	2.0	0.2	0.8	0.3	-0.2	-0.1	1.4	-1.2	-1.4	1.2	0.8	-1.1
Depressed Affect (Nagel 2018)	0.7	1.5	4.7	2.0	2.2	1.1	-0.3	0.7	1.2	-0.9	1.9	-0.2	0.3	-0.2
Depression (Nagel 2018)	1.3	2.0	7.8	-0.3	-0.3	-1.5	-0.9	-1.0	-0.8	2.3	2.8	-1.3	0.4	1.4
Intelligence (Savage-Jansen 2018)	0.9	2.8	12.0	0.4	1.1	1.5	1.8	3.5	-0.3	-1.3	1.1	2.7	0.4	1.0
Neuroticism (Nagel 2018)	0.4	1.0	5.9	-0.7	0.0	0.1	-0.3	-0.6	-0.8	1.0	1.2	-2.4	-0.4	1.2
Schizophrenia (2018)	1.1	2.3	6.7	1.3	1.1	0.9	0.8	0.9	1.3	-2.1	-1.9	2.6	1.0	-1.6
Schizophrenia vs Biploar Disorder	0.8	1.0	2.5	1.3	1.6	-0.0	-0.0	0.3	-0.4	-1.3	-1.4	1.6	0.1	-0.9
Worry (Nagel 2018)	0.5	1.1	3.7	-1.8	-0.3	1.0	-0.5	-1.1	-0.5	0.6	0.1	-1.9	-0.7	1.3
Alzheimer’s Disease (in mother)	0.4	0.5	3.2	0.7	0.1	0.5	0.3	-0.3	0.3	0.1	-0.0	-0.9	1.8	-0.2
Alzheimer’s Disease (in father)	0.4	0.4	1.7	-0.5	-0.8	0.9	0.1	-0.2	0.3	0.1	-0.3	1.3	-0.4	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.5	-0.5	0.7	-0.0	-0.6	0.7	-0.3	-0.3	-0.3	0.9	-0.4
Crohns Disease (2017)	1.0	2.2	5.7	2.1	0.8	1.8	1.4	1.3	1.3	-1.7	-0.6	-1.0	-0.1	-2.4
Irritable Bowel Disease (IBD)	2.1	5.0	11.3	2.4	1.7	2.8	1.9	1.2	1.8	-2.7	-3.4	-1.0	0.1	-3.2
Ulcerative Colitis (UC)	2.9	5.5	23.9	1.7	1.9	2.6	1.5	0.5	1.7	-2.9	-4.9	-0.9	0.6	-3.0
Major Depression (MDD)	0.3	0.4	1.4	0.7	0.6	0.7	-0.0	0.3	1.2	-0.1	0.8	-0.1	0.6	0.8
Reaction Time	4.0	7.6	18.2	-3.5	-3.3	-3.8	-2.3	-3.6	-1.6	4.3	1.2	-1.7	-1.3	0.4
Verbal and Numeric Reasoning (VNR)	1.6	3.8	16.1	1.2	1.7	2.2	2.4	4.0	0.2	-2.3	0.1	1.9	1.0	0.6
Breast Cancer	0.8	1.9	4.5	-1.9	-0.5	-1.0	-1.1	-1.8	0.0	2.1	1.4	-0.1	-1.1	1.9
Ovarian Cancer	0.2	0.3	1.1	0.4	0.8	-0.2	-0.6	-0.4	0.6	0.4	0.3	0.5	1.0	0.3
Prostate Cancer	0.5	0.8	2.3	-1.1	0.0	0.1	-0.9	-0.8	-0.2	0.7	1.2	1.1	-0.5	1.5
Age at First Birth	1.8	2.7	7.8	-2.8	-2.1	-1.9	-0.2	-0.8	-2.0	2.3	0.0	-1.0	0.3	1.4
Bipolar Disorder (2011)	0.7	0.7	2.3	-1.5	0.0	-0.3	-1.2	-1.4	-0.0	-0.3	-0.9	-0.3	-0.6	0.1
Body Mass Index (BMI) (2010)	0.7	0.9	4.2	-0.1	0.3	-0.2	-2.1	-1.5	0.9	-1.0	-0.2	1.1	-0.3	-0.1
Coronary Artery Disease (CAD)	0.3	0.4	1.8	0.1	-0.5	1.3	0.3	0.3	-0.3	-0.0	-0.4	0.5	-1.2	0.4
Crohns Disease (2012)	0.4	0.6	1.7	1.0	0.1	0.4	0.5	0.4	0.7	-0.3	0.8	-1.1	-0.9	-1.3
Mean Putamen Volume	1.5	1.7	6.5	-2.5	-1.1	-0.6	-1.0	-2.0	-0.6	1.4	-0.6	-1.7	-0.2	0.3
Fasting Glucose	0.7	0.8	2.6	-0.9	-0.4	-0.5	-0.8	-1.1	-0.6	1.3	0.8	-0.2	-1.6	0.8
HbA1C	0.8	0.9	3.4	0.2	1.3	-0.3	0.1	0.5	-1.5	-0.5	0.3	1.9	-1.1	0.6
HDL Cholesterol	1.0	1.7	6.3	-1.8	-1.1	-1.0	-2.2	-2.5	0.4	-0.0	-1.1	-0.6	-0.8	-0.2
LDL Cholesterol	0.5	0.8	3.5	0.8	0.1	-1.2	-1.0	-0.9	1.9	0.4	0.3	-0.9	0.0	-0.6
Lupus	8.5	12.8	46.4	3.0	2.3	5.3	5.4	6.8	2.5	-2.9	-0.9	2.5	0.9	0.3
Neuroticism (2016)	0.3	0.4	1.9	-1.4	-0.6	0.2	0.1	-0.5	-0.6	0.4	-0.0	-1.1	0.2	0.6
Primary Biliary Cirrhosis	0.7	1.0	2.1	1.0	0.5	1.0	1.4	1.2	0.6	-1.3	-1.0	-0.1	-0.0	-1.4
Rheumatoid Arthritis	0.3	0.4	1.0	-0.7	-0.5	-0.9	-0.6	-1.0	-0.3	-0.0	-0.6	0.5	-0.2	-1.0
Schizophrenia (2014)	0.5	1.1	4.0	0.9	0.7	0.2	0.5	0.6	0.6	-1.4	-1.4	2.0	0.9	-1.0
Triglycerides	0.6	1.0	3.2	1.0	-0.8	0.4	-0.1	0.2	1.2	0.6	1.8	-1.2	-1.6	0.7
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.7	0.7	0.7	1.3	1.6	1.5	0.6	-0.5	0.0	-1.2	1.1	-0.1
Ulcerative Colitis	1.1	1.6	7.4	0.5	0.1	1.7	0.2	-0.3	1.9	-1.2	-2.7	0.3	-0.2	-1.4
Blood Eosinophil Count	0.2	1.8	4.9	1.1	1.6	-1.4	-2.2	-2.2	1.2	-0.7	0.4	1.0	0.4	-0.7
Blood Platelet Count	0.4	4.2	10.2	1.0	1.7	-3.0	-2.5	-2.6	-1.3	1.2	1.5	-3.2	2.1	0.7
Blood Red Count	0.4	3.6	21.2	-1.9	-0.3	1.5	-0.4	0.8	1.7	0.3	1.9	4.6	-2.3	0.4
Blood White Count	0.1	0.7	2.3	-0.3	-0.4	1.5	-0.7	-0.5	-1.1	-0.1	-0.5	0.7	-0.1	1.4
Heel T-Score	0.3	2.1	8.8	-0.1	0.4	0.4	-0.8	-1.9	3.0	-1.8	-2.3	0.5	0.5	-0.6
BMI	0.5	2.9	11.0	3.3	1.8	0.6	-0.7	0.2	2.7	-0.7	2.2	1.3	0.2	-1.7
Height	0.5	10.5	30.8	-2.1	-1.9	1.4	3.3	3.9	-5.3	5.5	2.3	-1.0	-2.5	3.0
Waist Hip Ratio (WHR)	1.0	4.6	9.1	-0.7	-0.9	-2.0	-2.1	-2.9	-1.4	3.0	2.3	-3.0	1.5	2.1
Systolic Blood Pressure	0.2	1.0	3.5	-0.9	-0.5	1.1	0.5	0.4	0.9	1.1	0.9	-1.9	0.3	1.4
Smoking Status	1.6	3.8	11.2	3.3	2.5	1.7	1.7	1.8	1.4	-0.9	0.6	-2.6	1.5	-1.7
Allergy or Eczema	0.2	0.5	1.7	0.7	0.6	-0.6	-0.1	-0.4	1.2	-0.3	0.1	-1.3	0.4	-0.6
Cardiovascular Disease	0.4	1.5	5.8	1.0	2.4	1.5	-0.0	0.9	1.4	-0.5	1.8	-0.7	0.6	0.0
Hypothyroidism (self reported)	1.1	2.5	7.1	-1.6	-1.0	1.6	2.3	2.7	-0.6	1.4	1.1	0.8	0.3	2.1
Respiratory disease	1.4	3.1	9.0	0.6	-1.0	-2.9	-1.6	-1.2	-1.0	2.4	3.0	-2.2	0.2	-0.0
Type 2 Diabetes (T2D) (2018)	1.0	1.9	5.7	0.3	0.6	2.4	1.9	1.7	0.4	0.5	1.4	-1.7	1.6	1.0
Lung FEV1/FVC ratio	2.2	11.1	23.0	2.1	1.2	4.6	4.8	3.9	2.8	-3.9	-3.8	2.4	1.2	-3.6
Lung FVC	0.6	3.0	13.6	-1.1	-0.1	0.4	-0.5	-1.1	1.5	-2.4	-3.7	2.7	-0.9	-1.0
Neuroticism	0.4	0.9	2.4	-1.3	-0.4	0.7	0.4	-0.1	-1.2	0.7	0.9	-1.5	0.1	1.4
Chronotype (morning person)	3.1	7.3	22.1	4.6	2.9	3.5	-1.4	-0.2	1.6	-4.7	-1.9	1.4	1.0	-2.2
Hair Pigment	0.0	1.0	3.2	1.1	0.4	0.3	1.8	1.8	-1.0	0.3	-1.0	0.6	0.8	-0.0
Tanning	0.0	0.4	1.0	-0.1	1.0	-0.7	-0.7	-0.5	-0.5	0.3	0.7	-0.9	0.4	0.5
Hand grip strength (left)	0.5	1.4	4.4	0.0	1.3	1.1	-0.2	0.8	1.3	0.6	2.1	-0.1	1.7	1.6
Number of treatments/medications taken	0.2	0.3	1.2	0.4	-0.2	0.3	-0.1	0.6	0.5	-1.1	1.1	0.5	-0.4	0.0
Average weekly spirits intake	0.9	1.1	3.7	0.8	-0.3	0.1	1.9	1.8	-0.2	1.1	1.9	-0.3	0.1	-0.2
Sensitivity / hurt feelings	1.0	1.7	8.2	-0.9	-1.2	-1.9	-1.1	-1.5	-0.4	0.5	0.3	-2.9	-0.0	0.4
Frequency of depressed mood in last 2 weeks	1.5	2.1	6.9	-0.6	0.4	-1.3	-1.0	-1.2	-0.8	2.5	2.6	-1.7	0.7	1.0
Hearing difficulty/problems: Yes	0.4	0.6	3.7	-0.4	-0.1	-0.5	-0.7	-0.3	0.1	0.2	1.9	-0.1	-1.5	0.4
Relative age of first facial hair	0.9	1.9	4.6	-1.1	0.7	-1.3	-1.3	-1.6	1.2	1.8	1.8	-2.1	0.9	-0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.9	-0.2	-0.4	0.0	-1.4	-1.2	0.7	-0.0	0.8	0.3	-0.7	-0.0
Ever used hormone-replacement therapy (HRT)	1.5	2.0	8.1	1.4	2.8	2.8	0.4	1.1	0.4	-1.3	0.1	-0.3	-0.6	-0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	0.6	-0.5	-0.1	-0.7	-0.5	-1.1	0.8	1.3	-1.1	0.1	0.2
Systolic blood pressure, automated reading	0.5	1.5	3.8	-0.4	-1.2	0.2	-1.0	-0.9	0.3	1.9	1.8	-1.1	-0.9	1.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.1	-0.0	-0.6	0.1	0.5	0.4	-0.7	0.2	0.0	-1.0	-0.3	0.5
Angina	0.2	0.3	0.8	-0.7	0.2	-0.9	-0.1	-0.2	-0.8	-0.5	0.2	-0.4	-0.7	0.6
Medication for hormone replacement therapy	0.9	1.0	8.0	-0.1	2.8	1.2	-0.4	0.4	0.8	-0.5	0.6	-0.5	-0.2	0.3
Vitamin and mineral supplements	0.6	0.9	1.8	0.8	1.1	0.4	-0.7	-1.0	0.5	-0.5	-1.2	-0.7	1.3	-1.4
Supplements: Zinc	0.6	0.7	2.1	-0.9	-0.6	-0.2	0.2	0.4	-1.4	1.3	-0.1	0.3	0.8	1.3
Medication: Co-codamol	3.0	3.4	11.4	2.6	1.2	0.8	-0.5	-0.3	3.4	-2.8	-1.5	1.0	0.8	-2.3
Medication: Metformin	0.4	0.6	3.5	-0.1	-0.1	1.9	1.3	0.7	-0.1	-0.5	-0.4	-0.5	-0.3	0.1
Diabetes (father)	1.0	1.3	3.0	-0.3	0.9	0.9	0.8	1.3	-0.2	1.7	1.7	0.8	-1.1	1.4
Diabetes (mother)	0.6	0.8	3.3	-0.2	-0.8	-0.2	-0.4	-0.6	-0.5	1.5	1.0	-1.8	-0.3	-0.6
Severe depression (siblings)	0.9	1.0	4.7	-0.1	-0.4	-0.8	-2.2	-1.6	0.2	0.8	0.6	0.9	-0.2	0.6
Pack years adult smoking proportion	0.5	0.7	2.6	0.5	1.6	-0.1	-1.3	-1.1	-1.2	-0.6	-0.3	-0.6	-0.1	0.1
Impedance of leg (right)	0.8	4.0	14.1	-3.8	-2.6	-1.2	0.0	-0.5	-1.2	2.5	1.7	-1.9	-1.3	2.4
Leg fat-free mass (left)	0.3	1.5	4.8	2.1	0.7	0.9	1.8	2.2	-1.0	0.6	0.5	0.8	0.1	-0.9
Trunk fat percentage	0.4	1.7	11.7	0.9	-0.2	0.2	-0.1	0.1	0.5	2.2	3.4	-1.0	-0.5	0.7
Hand grip strength (right)	0.6	1.6	6.6	0.3	1.3	1.1	-0.7	0.7	1.6	0.2	2.6	0.9	0.9	1.6
Townsend deprivation index at recruitment	0.7	1.0	3.5	1.6	1.5	1.9	0.4	0.8	-0.2	-0.9	-0.3	0.3	-0.1	-0.6
Current tobacco smoking	2.8	4.6	13.0	3.4	3.6	2.1	1.4	2.1	2.6	-1.6	0.6	-0.6	0.4	-2.2
Average weekly fortified wine intake	2.3	2.6	5.6	-1.9	-1.4	-1.7	-1.3	-2.4	-1.7	1.3	-1.8	-1.4	1.0	1.6
Maternal smoking around birth	0.8	1.2	4.5	1.9	1.2	0.7	-0.3	0.3	1.4	-1.0	0.3	-0.5	0.1	-2.1
Fed-up feelings	0.6	1.2	5.7	-0.4	0.4	1.0	-0.0	0.2	0.4	1.0	2.4	-1.8	-0.5	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	5.4	-0.5	-0.6	-0.5	-0.6	-1.0	-1.6	1.7	2.2	-2.3	-0.2	1.6
Relative age voice broke	1.4	2.2	6.4	-0.9	0.6	-2.0	-2.0	-2.5	0.9	1.6	1.1	-1.9	0.1	-0.0
Taking other prescription medications	1.1	1.7	4.3	1.4	0.5	1.2	1.8	2.1	0.7	-1.4	0.6	-0.8	1.9	-0.6
Age when periods started (menarche)	1.0	2.5	8.7	-1.6	-1.6	-2.9	-0.9	-1.4	-0.6	2.3	1.8	-0.5	1.0	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.2	1.4	1.5	0.1	-0.9	-0.5	0.1	0.3	1.2	-0.3	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.6	0.0	1.6	-0.1	-0.7	-0.4	0.6	-0.3	1.1	0.6	-0.6	0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.3	-0.5	-0.7	-0.4	0.4	0.2	0.6	0.8	1.5	0.1	0.5	0.5
Qualifications: CSEs or equivalent	1.5	2.0	7.1	2.5	0.5	-0.0	-0.6	0.3	2.3	0.1	2.7	1.0	0.3	-1.2
Serious illness, injury or assault to yourself	0.5	0.6	4.5	0.5	0.2	0.1	0.3	0.4	-0.5	-0.1	-1.0	2.1	0.6	0.3
High blood pressure	0.5	1.4	5.2	1.6	2.3	1.4	0.2	1.0	1.3	-1.2	0.6	0.4	0.8	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.6	1.3	1.0	-0.5	0.3	0.4	1.6	-1.2	0.1	-0.8	0.8	-0.7
Multivitamins +/- minerals	1.9	2.4	6.1	-1.8	-1.7	-1.4	0.2	0.9	-1.0	1.7	2.5	1.7	-0.7	2.0
Stomach or abdominal pain in last month	1.1	1.3	7.1	-0.1	-0.4	0.3	1.5	1.6	-2.7	-0.3	-1.0	0.8	-0.9	-0.3
Supplements: Glucosamine	0.8	1.0	3.5	-0.8	-0.4	-0.3	0.4	1.0	-0.5	1.4	1.6	-0.5	-0.7	1.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.7	-0.3	0.4	1.3	0.0	-0.1	-0.5	-0.4	-0.8	-0.1	0.2	0.4
Medication: Atenolol	1.0	1.3	3.4	1.2	1.9	0.3	1.0	1.3	0.8	-1.7	-0.5	1.1	-0.2	-1.1
Medication: Levothyroxine sodium	1.0	1.7	5.0	-1.2	-1.6	0.9	1.3	1.0	-1.0	1.8	0.7	-0.6	0.9	2.2
Sitting height	0.9	6.3	25.1	0.6	0.8	2.5	4.7	5.0	-2.6	-0.3	-2.0	-0.2	-0.7	-1.8
Chronic bronchitis/emphysema (father)	1.0	1.2	3.4	-0.2	-0.1	-0.9	-1.8	-1.8	1.3	0.8	1.0	-1.1	1.0	0.5
High blood pressure (mother)	0.3	0.4	1.0	0.2	-0.2	-0.1	-0.9	-0.8	0.9	0.1	-0.0	-0.3	-1.0	-0.5
Body mass index (BMI)	0.6	2.6	11.8	3.4	1.8	1.0	-0.1	0.4	2.1	-0.4	2.1	0.8	0.2	-1.6
Impedance of leg (left)	0.5	2.4	8.6	-2.9	-1.9	-0.9	-0.1	-0.6	-0.5	1.8	1.2	-2.2	-1.0	1.6
Leg predicted mass (left)	0.3	1.6	5.0	2.2	0.8	0.9	1.8	2.2	-0.9	0.5	0.4	0.9	0.1	-1.0
Trunk fat mass	0.4	1.9	12.2	1.3	0.0	0.5	0.5	1.0	0.2	2.2	3.5	-0.5	-0.4	0.5
Waist circumference	0.5	1.8	10.8	1.7	1.1	-0.1	-0.6	-0.4	0.2	1.9	3.3	-0.9	0.1	0.3
Number of incorrect matches in round	0.4	0.7	1.9	-1.4	-1.4	-0.8	0.3	-0.4	-0.1	1.3	0.0	-0.5	-0.9	0.4
Past tobacco smoking	0.5	1.0	4.6	-1.8	-0.3	-0.4	-0.7	-0.4	-0.3	0.2	-0.6	2.1	-1.1	0.7
Alcohol usually taken with meals	1.5	2.4	5.6	-2.4	-2.1	-1.1	0.7	0.4	-2.1	0.1	-1.5	1.9	0.1	2.0
Nervous feelings	2.3	4.3	10.8	-3.3	-2.7	-1.3	-1.2	-2.3	-1.8	1.8	-0.6	-1.5	-2.5	2.3
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	10.0	-1.3	-0.1	-1.1	-1.7	-1.8	-1.3	2.5	3.2	-2.2	0.6	2.2
Hearing difficulty/problems with background noise	0.4	0.6	2.0	-0.1	0.1	-1.4	-0.7	-0.8	0.9	-0.0	1.4	-0.5	-0.6	-0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.5	-0.5	-0.6	-0.5	1.1	1.2	-0.6	0.5	0.0	-0.4	1.1	0.6
Had menopause	0.7	0.9	3.6	-1.1	-1.9	0.0	-0.8	-0.8	-0.1	0.3	0.3	-0.4	-1.7	0.6
Had other major operations	0.8	1.0	2.9	-1.1	-0.1	-0.6	-1.0	-0.9	-0.1	1.3	1.7	0.1	-1.1	1.3
Forced vital capacity (FVC)	0.6	2.3	8.7	-2.5	-0.8	0.1	0.7	0.5	-0.7	-0.4	-1.9	2.2	-3.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	5.5	-0.0	2.3	0.2	-1.1	-0.9	1.9	-0.6	0.8	0.6	-0.2	-0.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.1	1.5	-0.1	-1.0	-1.2	-0.7	1.4	-1.3	0.2	1.0	0.9	-1.1
Qualifications: None of the above	0.9	1.9	9.4	2.1	0.9	-0.1	-0.8	-1.3	1.6	0.2	0.7	-3.1	-0.0	-1.0
Financial difficulties in last 2 years	0.7	0.9	3.1	1.4	0.4	0.1	0.0	0.9	0.2	0.4	1.6	1.8	1.2	-0.3
Mouth/teeth dental problems	1.9	2.9	6.7	0.7	1.2	-1.1	-1.9	-1.1	2.5	-1.7	-0.2	2.6	-1.5	-2.3
Heart attack	1.3	1.6	4.6	0.9	1.0	1.2	1.1	0.8	1.2	-2.1	-1.1	0.6	2.1	-0.8
Allergy	0.5	1.1	3.7	-1.9	-0.6	1.4	1.1	0.3	-1.3	0.8	-1.4	0.2	-0.3	0.8
Pain all over the body in last month	0.5	0.5	2.9	0.1	-0.1	0.1	-1.0	-1.0	1.7	0.5	0.9	0.3	0.1	0.3
Diabetes (self-reported)	0.7	1.1	3.6	0.7	0.8	1.6	1.9	1.6	-0.2	-0.4	-0.4	-0.8	1.0	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	0.6	0.7	0.2	-0.5	0.0	0.1	-0.7	0.9	0.2	-0.2	-0.3
Medication: Ramipril	0.7	1.0	4.5	1.0	0.8	0.4	0.8	0.7	0.7	-0.3	1.5	-2.1	-0.4	0.1
Medication: Simvastatin	0.5	0.7	2.7	-0.0	0.1	1.6	-0.0	0.4	-0.8	0.2	1.5	0.6	-1.1	0.6
Fluid intelligence score	0.7	1.5	8.6	-0.0	0.1	0.5	1.6	2.9	-0.1	-1.6	0.8	1.3	0.1	-0.2
Illnesses of siblings	0.8	1.2	3.5	-1.4	-0.9	-1.9	-0.7	-1.2	-1.2	0.7	-1.2	0.9	-0.6	0.1
Neuroticism score	0.3	0.7	3.1	-1.1	0.1	0.6	-0.3	-0.4	-0.0	0.2	1.0	-1.8	-0.8	0.8
Weight	0.3	1.6	4.3	2.0	0.9	1.0	1.3	1.8	-0.0	1.2	2.1	0.4	-0.7	-0.6
Impedance of arm (right)	1.4	6.4	17.6	-4.2	-3.1	-2.2	-0.9	-1.5	-2.4	3.1	0.9	-2.6	0.0	3.5
Arm fat percentage (right)	0.4	1.7	12.3	1.4	0.5	0.0	-0.5	-0.0	1.2	1.5	3.5	-0.3	0.3	0.4
Trunk fat-free mass	0.3	1.7	6.6	1.2	0.7	0.7	2.1	2.6	-1.4	0.7	0.3	0.9	-0.9	-0.9
Hip circumference	0.4	1.6	9.3	0.8	0.9	0.0	0.3	0.9	-0.4	1.8	3.0	-0.0	-1.5	0.3
Time employed in main current job	1.3	1.5	4.1	-1.6	-2.0	-0.8	-1.3	-1.8	-0.8	1.3	-0.1	-1.2	-0.5	0.5
Alcohol intake versus 10 years previously	0.7	1.0	2.3	1.5	1.4	0.6	-0.6	-0.5	1.1	-0.4	0.6	0.9	1.5	-0.8
Father’s age at death	0.7	0.9	2.1	-0.8	-1.2	-1.1	-0.6	-1.1	-0.7	1.2	-0.1	-1.0	-1.4	0.5
Worrier / anxious feelings	0.8	1.5	8.6	-1.5	-1.0	-0.2	-0.6	-1.7	-0.0	0.4	-0.2	-2.9	-1.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	2.3	-0.1	0.2	-0.0	-0.1	0.3	-0.2	-0.2	0.4	-0.3	1.5	1.0
Falls in the last year	0.5	0.7	3.6	0.5	0.7	-0.0	-0.0	0.8	0.2	0.9	1.9	1.4	-0.0	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	1.4	-0.1	1.2	0.7	0.3	-0.0	-0.6	-0.6	-0.2	-0.0	0.5	0.9
Number of live births	2.1	3.0	7.2	-0.5	-0.1	-1.6	-2.7	-2.1	1.8	2.1	2.7	0.6	-1.9	0.1
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	6.7	-1.3	0.2	1.6	2.1	1.7	0.4	-1.5	-2.6	2.4	-2.0	-1.7
Pulse rate	1.6	2.7	5.5	0.1	1.8	2.3	2.2	2.3	0.4	-2.0	-1.3	1.5	1.7	-0.1
Happiness	0.5	0.6	1.5	0.6	-0.6	-1.2	-1.2	-0.8	0.0	-1.0	0.2	0.8	0.3	-0.5
Noisy workplace	0.7	0.8	2.6	0.1	0.2	1.1	1.6	1.6	1.0	0.6	0.5	0.7	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.9	2.1	7.6	-0.3	1.1	1.1	0.9	2.0	0.9	-1.7	-0.5	2.8	2.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	3.9	0.5	0.4	-0.7	0.1	0.5	0.3	-1.2	-0.6	1.6	-2.0	-1.1
Mouth/teeth dental problems: Dentures	0.8	1.3	6.3	0.5	-0.7	0.1	0.8	0.2	-2.1	0.7	-0.3	-2.5	0.9	0.9
Asthma	0.8	1.7	6.6	1.4	0.3	-1.8	-1.3	-0.5	0.4	0.9	2.6	-1.2	1.5	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.1	0.5	-0.2	-0.1	0.2	0.4	-1.1	-1.4	0.4	0.7	-0.8	0.2
Medication: Cholesterol lowering	0.2	0.3	0.9	-1.0	-0.0	0.9	-0.1	-0.1	0.4	0.3	0.4	0.3	-0.0	0.8
Depression (self-reported)	0.8	1.0	5.2	-0.0	0.1	-1.2	0.4	0.4	-1.1	0.6	1.2	-2.3	-0.4	0.8
Medication: Lansoprazole	0.5	0.6	1.6	0.6	0.2	-0.6	-0.6	-0.2	-1.1	0.7	1.3	-0.4	1.0	0.7
Prospective memory result	0.4	0.5	1.7	0.5	-0.4	-0.0	-0.4	-1.0	-0.7	-0.5	-1.3	-0.6	0.6	0.5
Lung cancer (father)	0.7	0.8	2.4	-0.5	-1.1	-1.0	-1.2	-0.8	0.2	0.8	1.6	0.7	-0.4	0.7
Illnesses of mother	0.7	0.9	3.9	-1.2	0.1	-0.9	0.5	0.4	-2.0	0.6	-0.1	0.0	0.2	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	7.6	-0.5	0.4	1.2	2.1	1.9	1.1	-1.3	-2.3	2.8	-1.8	-1.8
Pulse wave Arterial Stiffness index	0.7	0.8	2.9	-0.7	-1.3	1.2	-0.1	0.3	0.2	-0.5	0.0	1.3	-1.7	-0.1
Impedance of arm (left)	1.3	5.9	13.3	-3.6	-2.9	-2.3	-1.4	-2.0	-2.5	2.8	1.1	-2.6	-0.4	3.2
Arm fat mass (right)	0.4	1.7	10.7	2.1	0.8	0.5	0.1	0.8	0.8	1.2	3.3	0.1	-0.3	-0.1
Trunk predicted mass	0.3	1.8	7.1	1.3	0.8	0.8	2.2	2.7	-1.2	0.7	0.3	1.0	-0.8	-1.1
Standing height	0.6	6.2	20.1	-2.6	-1.7	0.1	3.0	2.9	-4.5	3.5	0.2	-1.2	-2.1	1.9
Length of working week for main job	1.2	1.3	3.3	-1.6	-1.6	-1.3	0.1	0.1	-1.2	1.8	1.2	0.2	-0.8	0.7
Exposure to tobacco smoke at home	1.2	1.4	2.8	0.9	-0.3	0.3	1.7	1.5	-1.6	-1.5	-1.3	1.1	0.9	-0.8
Breastfed as a baby	0.3	0.4	3.0	0.6	0.3	0.1	-0.3	-0.3	-0.2	-0.3	-1.7	0.1	0.7	0.7
Tense / ‘highly strung’	0.5	0.8	2.9	-1.7	0.2	1.1	0.1	-0.4	0.2	-0.1	-0.0	-1.4	0.4	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.6	-0.2	0.5	-1.8	-2.4	-2.2	-0.1	0.9	1.4	-2.0	-0.8	0.8
Hair/balding pattern: Pattern 4	0.4	1.0	3.9	-0.6	0.6	1.8	0.7	0.7	2.0	0.1	0.4	-0.1	-1.3	0.0
Birth weight of first child	1.5	2.7	5.8	-2.4	-2.0	-1.9	-0.7	-0.9	-1.6	2.4	1.5	-1.3	0.5	1.7
Peak expiratory flow (PEF)	0.2	0.6	2.0	-0.4	0.4	0.8	0.4	0.8	0.0	-0.9	-0.1	1.1	-1.4	-0.7
Pulse wave reflection index	0.4	0.4	1.7	0.0	-1.2	-0.3	-0.4	-0.1	0.2	0.2	0.8	-0.7	-1.3	0.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.0	-1.7	-1.1	-0.7	-0.2	-0.6	-1.4	1.1	-0.1	0.7	-0.7	1.6
Loud music exposure frequency	1.2	1.3	2.9	1.6	0.2	-0.2	-0.8	-0.4	1.7	-0.2	1.6	-0.5	-1.7	-1.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.8	0.2	0.5	1.7	0.3	0.8	0.7	-1.6	-1.4	2.0	-0.8	-0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	4.5	-1.1	-0.8	1.8	1.2	1.1	-0.9	0.2	0.5	0.3	1.6	2.1
Blood clot in the leg (DVT)	0.6	0.8	3.0	0.4	-0.5	-0.1	-0.5	-0.0	1.6	-0.2	0.5	1.7	-1.5	0.2
Medication: Paracetamol	1.0	1.6	5.6	1.3	-0.4	0.4	-0.2	0.4	0.6	-2.4	-1.4	1.8	-1.1	-1.7
Headache pain in last month	0.2	0.3	1.3	-0.4	0.0	0.4	-0.3	0.0	0.1	0.8	1.1	-0.6	-0.9	0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.5	0.7	-1.2	-0.6	-0.2	-0.5	-0.2	-0.3	-0.7	-0.2	-0.3	-1.2
Glaucoma (self-reported)	1.1	1.2	2.7	-1.6	-0.7	-0.3	0.2	0.1	-1.1	1.2	1.4	-1.6	-0.7	1.6
Gout (self-reported)	1.8	2.5	10.5	-1.6	-1.9	-1.0	-0.9	-0.5	0.5	2.1	3.2	-0.1	0.4	2.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.9	-1.3	-0.6	1.1	1.5	1.3	-1.3	1.2	0.8	-0.4	0.6	2.0
Medication: Amlodipine	0.5	0.8	2.5	1.6	0.9	0.8	-0.1	0.3	1.3	-1.1	0.3	0.1	1.2	-0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	3.1	1.1	0.3	-0.6	-0.1	-0.2	-0.6	-1.3	-1.8	0.1	0.3	-1.3
Birth weight	1.1	2.3	10.3	-1.0	-1.4	-3.2	-2.0	-2.2	-0.1	1.1	1.2	-0.2	0.8	0.3
Chronic bronchitis/emphysema (mother)	0.8	0.9	4.1	1.6	2.0	1.4	-0.0	0.0	0.9	-0.3	0.3	0.2	0.0	-0.8
High blood pressure (siblings)	1.5	2.2	8.7	2.4	0.9	2.1	-0.1	0.6	3.0	-0.8	1.2	-0.8	-0.1	-1.1
Forced vital capacity (FVC), Best measure	0.5	1.9	7.8	-2.0	-0.4	-0.5	0.7	0.6	0.0	-0.0	-1.5	2.2	-2.8	-0.5
Body fat percentage	0.5	1.8	12.0	1.6	0.4	0.5	-0.0	0.2	1.3	1.6	3.5	-0.7	-0.1	0.1
Leg fat percentage (right)	0.6	2.2	14.6	1.9	0.4	0.4	0.0	0.5	1.9	1.3	3.8	0.2	-0.2	-0.4
Arm fat-free mass (right)	0.5	2.6	8.6	2.3	1.2	1.4	2.4	2.9	-0.2	0.0	0.5	1.3	-1.0	-1.6
Exposure to tobacco smoke outside home	1.5	1.9	8.8	-1.6	-0.8	0.5	-0.8	-0.8	-1.1	2.2	1.1	0.4	0.5	3.0
Comparative body size at age 10	0.4	1.1	4.3	-1.2	-1.0	-0.6	-1.6	-2.1	-0.3	0.9	-0.3	0.4	0.4	1.0
Number of full brothers	0.3	0.3	1.1	-0.1	-0.4	0.5	-0.7	-1.1	0.6	0.7	0.4	-0.9	0.3	0.1
Worry too long after embarrassment	1.0	1.7	10.5	-1.4	-0.1	-0.5	0.3	-0.6	-0.8	1.5	0.8	-3.2	-1.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.5	1.6	1.0	-0.7	-0.5	-0.4	0.5	-0.8	-0.5	-1.0	0.9	-0.9
Wheeze or whistling in the chest in last year	1.0	1.9	4.1	2.0	0.9	-1.8	-1.5	-0.7	1.8	-0.5	1.6	-0.5	1.7	-0.6
Number of children fathered	0.9	1.0	1.8	-0.2	-1.3	-0.7	-1.1	-1.2	1.0	-1.3	-1.1	0.2	-0.4	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.5	-1.6	-1.8	-0.7	-1.9	-1.7	-0.4	1.3	0.2	-0.4	-1.0	1.3
Age at first live birth	1.0	1.8	8.7	-2.9	-2.3	-1.3	-0.3	-0.4	0.2	-0.2	-0.8	1.3	-1.1	0.4
Pulse wave peak to peak time	0.7	0.9	2.7	0.6	1.3	-1.2	0.2	-0.3	-0.6	0.7	0.1	-1.6	1.6	0.3
Health satisfaction	1.4	1.9	4.4	1.7	0.9	1.5	0.8	1.6	0.8	-2.1	-0.3	1.8	0.9	-1.3
Shortness of breath walking on level ground	1.0	1.2	5.9	2.4	1.1	-0.1	-0.5	-0.3	1.1	-0.8	-0.1	1.1	0.5	-1.6
Qualifications: College or University degree	0.6	2.0	11.8	-1.9	-0.2	0.1	0.3	0.7	-0.6	-0.7	-2.0	3.4	-0.2	0.9
Eye problems/disorders: None of the above	1.5	1.8	5.5	1.8	1.0	0.3	0.6	0.1	0.4	-1.0	-2.4	-0.5	2.0	-1.9
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.0	1.0	0.5	0.3	0.7	1.0	-0.8	-0.6	0.2	0.8	0.2	-0.4
Emphysema/chronic bronchitis	0.8	0.9	2.9	1.0	0.1	0.4	-0.1	-0.4	-0.9	-1.7	-1.7	-0.4	-0.1	-1.5
Medication for pain relief, constipation, heartburn	1.3	2.2	9.4	-1.1	-0.3	-1.6	-1.1	-1.9	-0.1	3.1	0.2	-2.4	0.2	0.2
Neck or shoulder pain in last month	0.5	0.7	3.9	-1.3	0.5	0.7	-0.9	-0.8	-0.2	-0.1	0.1	0.1	-2.0	0.4
Medication: Blood pressure	0.2	0.4	1.4	-0.5	0.4	0.1	0.8	0.8	-0.2	0.2	0.5	-0.5	1.2	1.1
Angina (self-reported)	0.3	0.3	1.1	-0.6	0.4	-1.0	-0.3	-0.4	-0.7	-0.6	0.2	-0.6	-0.4	0.6
Migraine (self-reported)	1.2	1.5	5.7	0.4	0.0	1.0	1.0	2.0	0.6	-1.4	1.2	2.4	-1.1	0.2
Medication: Ibuprofen	0.5	0.6	1.7	-0.0	-0.7	-0.8	-0.7	-0.5	-0.8	-0.6	0.8	0.8	-1.3	0.5
Medication: Allopurinol	1.5	2.0	6.0	-1.4	-1.6	-1.0	-0.4	-0.3	0.8	2.3	2.5	-1.2	0.3	1.7
Medication: Omeprazole	0.3	0.4	0.9	0.9	0.4	1.0	0.7	0.5	0.1	-0.9	-0.6	0.5	0.2	-0.4
Medication: Seretide 50 evohaler	0.6	0.7	4.9	-0.1	-0.1	-0.3	-0.5	-0.6	0.2	1.4	0.3	-2.2	0.2	-0.1
Mean time to correctly identify matches	2.5	4.7	10.8	-2.9	-2.6	-2.7	-1.9	-3.2	-1.0	3.3	0.6	-1.5	-0.7	0.5
Heart disease (mother)	0.7	0.9	2.9	1.7	-0.7	1.4	-0.5	0.2	0.7	-1.4	0.2	0.3	-0.6	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.9	1.4	0.3	-0.0	-1.1	-1.0	1.2	-0.1	0.6	-0.6	0.5	0.0
Whole body fat mass	0.5	2.0	11.4	2.0	0.8	0.7	0.6	1.0	0.8	1.7	3.4	-0.4	-0.1	-0.1
Leg fat mass (right)	0.5	2.0	11.2	2.0	0.6	0.8	0.8	1.3	1.2	1.4	3.4	0.4	-0.3	-0.4
Arm predicted mass (right)	0.6	2.9	10.1	2.4	1.0	1.6	2.6	3.2	-0.5	0.1	0.7	1.4	-1.1	-1.5
Pulse rate, automated reading	0.6	2.0	5.3	-0.4	1.0	2.3	1.8	2.3	-1.5	-0.3	0.8	0.1	0.9	1.9
Alcohol intake frequency.	0.7	1.7	9.7	3.1	0.9	0.3	-0.5	-0.0	1.4	-0.0	1.0	-0.3	0.2	-2.3
Comparative height size at age 10	1.7	9.5	21.7	-4.6	-2.9	0.9	2.9	2.7	-4.7	3.8	-0.7	-1.4	-2.9	3.4
Number of full sisters	0.8	1.0	2.4	1.5	0.4	0.6	1.5	1.6	0.3	-1.3	-0.5	0.6	0.8	-0.7
Suffer from ‘nerves’	0.6	0.9	3.6	-1.3	-0.7	0.7	0.1	-0.3	-1.9	0.6	-0.1	0.1	-0.4	1.9
Overall health rating	0.4	0.9	2.7	1.6	0.0	1.1	0.4	1.2	-1.2	-0.8	1.4	-0.3	0.4	0.7
Chest pain or discomfort	0.5	0.7	2.2	0.1	0.2	-0.2	-0.2	-0.5	-0.3	1.4	1.5	-1.2	0.7	0.9
Had major operations	0.9	1.0	4.1	0.8	1.4	0.4	-0.1	-0.1	2.0	-1.8	-0.4	-0.4	0.3	-0.7
Age at last live birth	0.5	0.8	2.3	-1.5	-0.5	-1.2	-0.4	-0.6	0.8	-0.6	-1.0	1.2	0.3	-0.6
Family relationship satisfaction	0.2	0.2	1.2	-0.1	-1.1	-0.0	0.4	0.3	0.3	-0.3	0.1	-0.3	-0.7	-0.0
Leg pain on walking	0.6	0.7	1.7	-0.6	-0.3	0.8	1.3	0.8	0.1	1.3	0.8	-0.6	0.8	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.5	-0.2	-0.6	0.3	1.9	0.8	-0.2	-0.2	-1.3	-0.3	1.6	-0.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	8.2	-0.7	-0.9	-0.5	-1.1	-0.5	0.1	0.7	2.3	0.7	-2.9	-0.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	8.0	-1.7	-0.1	1.1	0.5	-0.4	-0.6	0.8	-0.4	-2.8	1.0	1.1
Medication: Aspirin	1.2	1.6	4.3	-0.1	1.2	1.4	1.1	2.1	0.5	-1.2	1.7	1.6	0.5	1.1
Supplements: Vitamin C	0.8	0.9	3.2	0.2	0.3	1.8	1.4	1.6	-0.2	-0.9	-0.4	0.7	0.7	0.3
Knee pain experienced in last month	1.6	2.4	8.8	2.5	0.4	1.5	2.1	3.0	-0.3	-1.3	1.5	0.5	0.6	-0.3
Hypertension (Self-reported)	0.7	1.9	5.3	1.9	2.3	1.5	0.6	1.5	1.7	-1.4	0.8	0.7	1.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.4	0.7	-0.1	0.9	0.2	0.0	0.2	0.2	0.6	-1.2	0.6	-0.1
Illnesses of father: Heart disease	2.3	3.1	10.5	1.4	0.8	2.0	2.4	3.2	0.7	-1.3	-0.9	2.6	0.9	-1.1
Illnesses of siblings: Diabetes	1.5	1.8	6.2	0.1	2.3	0.8	0.2	-0.1	-0.7	1.6	0.9	-2.5	1.8	1.1
Smoking status: Previous	0.4	0.6	3.3	-0.1	-0.8	-0.5	0.3	-0.1	-1.1	0.6	0.3	-1.8	0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.4	-0.6	0.6	0.0	0.6	0.4	-1.5	1.2	0.8	-1.3	-0.9	1.2
Whole body fat-free mass	0.3	1.9	7.0	1.9	0.9	1.0	2.2	2.6	-1.1	0.5	0.2	1.0	-0.5	-1.2
Leg fat-free mass (right)	0.3	1.8	6.5	2.5	1.2	1.1	1.7	2.1	-0.5	0.0	-0.1	0.8	0.1	-1.5
Arm fat percentage (left)	0.4	1.8	12.6	1.8	0.5	-0.0	-0.6	-0.1	1.1	1.3	3.5	-0.1	0.1	0.3
Average weekly red wine intake	1.3	2.0	6.6	-1.6	-0.7	-1.3	-0.0	0.2	-1.7	1.8	2.1	-0.1	0.2	2.6
Handedness (chirality/laterality): Left-handed	1.7	2.1	4.0	-1.5	-1.2	-1.9	-2.0	-1.9	-0.3	1.8	1.7	-0.1	-1.1	0.7
Mood swings	0.3	0.5	2.4	0.4	1.1	0.2	-0.9	-0.3	0.4	0.1	1.6	-0.4	-0.5	0.3
Loneliness, isolation	0.4	0.6	2.2	-0.1	-0.7	-0.6	0.3	0.1	-1.0	1.0	1.5	-0.7	0.5	0.7
Long-standing illness, disability or infirmity	0.6	0.9	2.6	1.3	0.0	0.6	-0.7	-0.3	0.9	-1.5	0.5	-1.6	0.6	-1.0
Ever had bowel cancer screening	0.4	0.5	1.3	-0.8	-0.4	0.8	0.4	-0.4	-0.6	0.8	-1.2	-0.6	0.7	0.5
Diabetes diagnosed by doctor	0.4	0.6	1.3	0.6	1.1	1.1	0.9	0.7	-0.3	-0.2	0.4	-1.1	1.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	6.7	-0.2	-0.0	-1.1	-1.0	-0.7	0.9	1.5	2.6	-0.7	-1.1	0.0
Friendships satisfaction	0.6	0.7	3.9	-0.0	0.3	0.2	2.0	1.6	-0.6	0.1	-0.5	-0.2	0.3	-0.7
Qualifications: nursing, teaching	0.2	0.4	1.3	-0.1	-0.6	0.5	-1.1	-0.5	-0.3	-0.7	-0.2	1.1	-0.4	-0.1
Commuting to job workplace: Walk	1.8	2.0	7.2	0.0	0.8	1.9	2.0	1.6	0.3	0.2	-1.3	-1.4	2.7	0.3
Eye problems/disorders: Cataract	1.3	1.5	7.5	-0.1	0.6	0.6	-0.2	0.6	-0.1	-0.7	1.9	1.9	-2.7	0.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	9.9	-1.8	-1.3	-0.1	0.8	-0.5	-1.1	2.3	-0.1	-3.1	-0.3	1.0
Medication for cholesterol	1.3	2.0	5.2	-0.7	-2.2	-1.8	1.0	0.0	-1.1	2.3	-0.6	-1.4	1.6	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	0.0	-1.0	0.9	-0.7	-0.8	-0.6	-0.6	-0.3	-0.5	-1.2	-0.1
Back pain experienced in last month	1.4	2.1	6.9	2.6	2.0	0.4	-0.9	-0.4	1.3	-2.0	-1.0	-0.2	0.3	-1.8
Mineral and other dietary supplements	1.3	1.7	4.9	0.8	1.6	1.7	-0.6	-1.4	0.3	-1.1	-2.2	1.2	-0.0	-1.7
Breast cancer (self-reported)	0.7	0.8	3.4	0.8	0.8	0.0	1.1	1.8	-0.3	-1.5	0.7	0.5	-0.1	-0.1
Asthma (self-reported)	1.0	2.0	7.1	1.4	0.1	-2.0	-1.7	-1.0	0.4	1.1	2.7	-1.5	1.2	-0.1
Osteoporosis (self-reported)	1.6	1.9	5.0	2.2	0.8	1.1	0.4	0.9	1.7	-2.1	-0.5	0.6	2.0	-1.1
Osteoarthritis (self-reported)	1.5	2.0	5.2	1.7	1.9	1.2	1.8	2.2	0.0	-2.3	0.1	0.7	0.5	-0.5
Medication: Aspirin	1.0	1.3	3.0	-0.3	0.9	1.3	1.1	1.7	0.3	-1.3	1.4	1.5	0.4	1.1
Medication: Gliclazide	0.9	1.0	3.0	0.1	-0.8	1.4	0.3	-0.5	1.4	-1.7	-1.7	0.3	-0.1	-0.4
Illnesses of father: None of the above (group 1)	1.0	1.2	3.9	-0.9	-0.9	-2.0	-1.3	-1.7	-0.3	0.7	0.9	-1.2	-0.5	-0.3
Smoking status: Current	2.9	4.6	12.5	3.5	3.5	2.2	1.4	1.9	2.8	-1.4	0.8	-0.9	0.4	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	8.3	-1.7	0.4	0.7	0.6	0.7	1.3	-0.8	-1.3	2.9	-1.5	-0.5
Whole body water mass	0.4	2.2	7.7	2.1	1.0	1.2	2.3	2.8	-0.9	0.3	0.1	1.1	-0.4	-1.3
Leg predicted mass (right)	0.3	1.9	6.6	2.6	1.2	1.1	1.8	2.2	-0.6	-0.0	-0.1	0.8	0.1	-1.5
Arm fat mass (left)	0.4	1.8	10.7	2.1	0.9	0.6	0.3	0.9	0.8	1.2	3.3	0.2	-0.3	0.0
Number of self-reported non-cancer illnesses	0.5	0.8	2.5	1.6	1.2	0.6	-0.4	0.4	0.8	-1.0	1.6	-0.0	0.1	-0.8
Average weekly champagne plus white wine intake	2.6	3.6	7.1	-2.5	-1.5	-2.0	-2.6	-2.3	-1.3	1.8	1.2	0.8	-0.9	2.7
Miserableness	1.0	1.7	7.0	0.8	1.9	1.9	0.6	1.5	1.1	-0.5	2.6	-0.3	-0.5	-0.3
Guilty feelings	2.5	3.7	9.2	-2.5	-3.0	-2.1	-0.8	-1.2	-0.6	3.0	1.9	-0.5	-1.4	2.0
Wears glasses or contact lenses	0.1	0.1	0.7	-0.2	-0.3	0.4	-0.1	0.2	-0.1	0.0	0.2	-0.9	0.1	0.5
Ever taken oral contraceptive pill	0.9	1.1	3.5	0.3	-0.0	0.3	1.9	1.6	0.6	-0.7	-0.9	0.0	1.9	-0.7
Hearing aid user	0.7	0.7	3.1	0.4	-1.8	-0.8	0.1	0.3	0.7	-0.7	1.1	-0.3	-1.3	-0.6
Mother’s age at death	0.6	0.7	1.9	-0.0	-0.1	-0.7	-0.3	-0.6	1.4	-0.9	-0.8	1.4	-0.5	-1.2
Financial situation satisfaction	0.7	0.9	3.4	1.9	0.2	-0.2	0.8	1.1	1.0	-0.5	1.1	1.1	0.5	-1.0
Tinnitus: Yes, now most or all of the time	0.9	1.1	4.0	0.5	-0.9	0.6	0.6	0.9	2.0	-0.4	0.2	1.6	-1.0	-1.2
Commuting to job workplace: Public transport	2.7	3.2	13.9	-3.2	-1.6	0.0	0.3	-0.1	-1.9	2.1	-0.1	-0.7	0.6	3.7
Eye problems/disorders: Glaucoma	0.3	0.3	1.4	-0.9	-0.4	0.3	0.1	-0.1	-0.3	0.7	0.3	-1.2	-0.3	0.7
Medication: Blood pressure	1.7	3.2	8.1	1.9	2.1	2.3	0.2	1.0	1.7	-2.8	-0.8	2.2	-0.6	-2.0
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.3	1.4	0.6	1.4	0.8	1.5	1.4	-1.4	0.7	0.9	-1.4	-0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.5	-0.2	-1.3	-2.0	-0.0	0.8	0.5	1.0	2.3	-0.5	-0.3	1.0
High cholesterol (Self-reported)	0.7	1.3	6.1	-0.4	0.5	0.6	-2.5	-2.1	0.6	0.5	1.6	0.6	-0.2	0.4
Medication: Bendroflumethiazide	0.5	0.8	2.2	0.4	0.1	0.7	-0.9	-0.4	1.2	-1.3	-0.7	0.7	-1.5	-0.8
Medication: Paracetamol	1.3	2.0	6.1	1.5	-0.9	0.2	-0.8	-0.1	0.5	-2.1	-1.0	2.5	-1.9	-1.7
Medication: Lisinopril	0.7	0.9	2.0	-0.7	-1.0	-1.1	-1.4	-1.2	-0.4	1.3	0.6	0.7	-0.3	0.9
Medication: Atorvastatin	0.8	0.9	2.0	-0.4	0.8	1.2	0.8	0.6	1.3	-1.4	-1.2	0.3	0.5	-1.3
Illnesses of father: High blood pressure	0.5	0.7	1.5	0.4	0.7	0.5	1.2	1.1	-0.8	-1.1	-1.2	0.2	-0.6	0.5
Alcohol drinker status: Never	0.3	0.4	0.9	0.7	-0.2	-0.3	-1.0	-0.6	-0.8	0.1	0.8	-0.6	-0.9	-0.2
Ever smoked	0.5	0.9	3.7	1.9	1.2	0.5	0.6	0.4	0.5	-0.5	0.1	-1.4	0.9	-0.7
Basal metabolic rate	0.3	1.9	6.3	2.1	1.1	1.0	2.0	2.5	-0.7	0.6	0.7	0.8	-0.5	-1.1
Leg fat percentage (left)	0.7	2.6	11.0	2.6	1.1	0.7	0.1	0.4	2.6	0.6	3.3	0.2	0.2	-1.2
Arm fat-free mass (left)	0.4	2.2	8.0	1.8	1.0	1.2	2.3	2.8	-0.2	0.4	0.7	1.1	-1.1	-1.3
Number of operations (self-reported)	0.3	0.4	1.6	0.5	1.0	0.4	-0.1	0.0	0.7	-1.3	-0.3	0.3	-0.9	-0.3
Average weekly beer plus cider intake	0.6	0.9	3.3	0.3	1.7	0.3	1.6	1.8	0.1	-0.6	0.6	0.8	0.0	0.3
Irritability	0.4	0.6	1.7	-0.5	0.1	1.0	1.2	1.3	-0.8	-0.4	0.8	-0.7	-0.2	0.8
Risk taking	0.8	1.2	4.2	0.2	0.1	-1.5	-0.1	0.1	-1.1	1.6	2.0	1.0	-1.0	0.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.9	0.0	0.4	-0.6	0.0	0.1	-0.1	0.4	0.2	0.5	0.5	1.0
Fractured/broken bones in last 5 years	1.2	1.5	3.9	0.5	-0.8	-1.5	-1.5	-1.5	0.4	-2.0	-0.7	1.8	0.7	-0.6
Age started oral contraceptive pill	0.4	0.6	2.0	-0.7	-0.3	0.6	0.5	-0.1	-1.4	-0.9	-1.3	0.3	-0.2	0.6
Diastolic blood pressure, automated reading	1.2	3.8	14.7	2.6	2.5	2.5	-0.3	0.4	3.8	-1.7	0.8	0.0	1.7	-0.9
Ever depressed for a whole week	0.7	0.9	2.8	0.8	0.1	-0.1	-1.6	-1.3	1.7	-1.1	-0.5	-0.1	0.2	-1.0
Unable to work because of sickness or disability	0.8	1.0	2.1	1.4	1.0	1.1	-0.4	0.2	1.4	-1.5	1.0	0.6	0.9	0.1
Commuting to job workplace: Cycle	0.7	0.8	2.6	0.7	1.6	-0.7	-0.3	0.2	1.5	-1.1	-0.8	0.5	0.8	-0.7
Myopia	1.2	1.7	4.5	1.3	1.9	0.4	1.1	0.8	1.0	1.4	2.1	-1.9	0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.7	-1.5	-2.2	-1.4	-0.1	-0.8	-1.2	1.5	-0.6	-0.4	-0.6	0.3
Cholesterol lowering medication	0.8	1.1	4.5	-0.0	-0.4	0.5	-0.7	-0.3	-1.1	-1.1	1.2	1.5	-2.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	0.6	0.4	0.5	-0.1	-0.2	0.3	-0.9	-0.3	0.8	-0.6	-0.4
Pain experienced in last month	0.3	0.5	1.7	-0.7	-1.1	-0.8	-0.0	-0.7	-0.8	0.2	-1.3	0.1	-0.2	0.1
Supplements: Calcium	1.2	1.4	3.7	-0.1	-0.5	1.0	1.9	1.4	-1.0	-1.0	-1.8	-1.3	1.1	0.2
Basal cell carcinoma (self-reported)	1.1	1.3	4.8	0.4	1.3	1.1	0.5	-0.2	1.0	-0.8	-2.2	-1.0	0.8	-1.6
Heart attack/myocardial infarction (self-reported)	1.5	1.9	5.0	1.1	1.2	1.2	1.3	1.0	1.4	-2.2	-1.2	0.6	2.0	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.4	0.5	-0.5	-0.1	-0.5	-0.1	1.8	-0.2	0.4	1.7	-1.3	-0.2
Heart disease (siblings)	0.5	0.7	1.9	-0.2	-1.2	0.5	1.4	0.8	-0.7	-0.6	-0.9	-0.1	0.7	-0.9
Alcohol drinker status: Previous	0.8	0.9	2.6	1.5	0.2	0.6	0.1	0.2	0.8	0.7	1.6	-1.3	1.2	-0.2
Pack years of smoking	0.3	0.5	1.6	-0.1	0.9	-0.1	-1.1	-1.0	-1.3	0.1	-0.2	-0.5	-0.4	0.5
Impedance of whole body	1.0	5.1	14.6	-3.8	-2.9	-1.7	-0.8	-1.3	-1.9	2.6	1.3	-2.5	-0.8	3.0
Leg fat mass (left)	0.6	2.2	9.5	2.3	1.0	1.0	0.8	1.3	1.6	1.0	3.1	0.4	-0.1	-0.7
Arm predicted mass (left)	0.5	2.5	10.0	1.8	1.0	1.4	2.6	3.2	-0.2	0.5	0.8	1.3	-0.9	-1.1