Best TWAS P=1.07e-11 · Best GWAS P=1.37e-11 conditioned to 0
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | LOC100128398 | 0.25 | 0.19 | lasso | 5 | 0.24 | 2.3e-29 | -6.4 | 5.8 | 8.7e-09 | -0.63 | 0.01 | 0.99 | TRUE |
2 | GTEx | Artery Aorta | AC007228.11 | 0.31 | 0.22 | enet | 24 | 0.23 | 6.5e-13 | 5.3 | 5.4 | 5.3e-08 | 0.05 | 0.00 | 0.99 | FALSE |
3 | GTEx | Artery Coronary | AC007228.11 | 0.30 | 0.15 | lasso | 6 | 0.10 | 2.1e-04 | 5.0 | 5.5 | 4.1e-08 | 0.00 | 0.01 | 0.98 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | CTD-2368P22.1 | 0.42 | 0.04 | enet | 26 | 0.12 | 2.4e-04 | 3.8 | 5.7 | 1.5e-08 | -0.50 | 0.08 | 0.42 | FALSE |
5 | GTEx | Brain Hippocampus | SLC27A5 | 0.19 | -0.01 | lasso | 18 | 0.00 | 4.1e-01 | -4.6 | 6.2 | 7.8e-10 | -0.17 | 0.04 | 0.40 | TRUE |
6 | GTEx | Brain Hypothalamus | AC007228.11 | 0.39 | 0.24 | lasso | 6 | 0.22 | 8.8e-06 | 5.3 | 5.2 | 1.8e-07 | 0.03 | 0.01 | 0.98 | FALSE |
7 | GTEx | Breast Mammary Tissue (Male) | CTD-2583A14.8 | 0.01 | -0.01 | enet | 7 | 0.00 | 4.0e-01 | -6.2 | 5.8 | 7.7e-09 | -0.62 | 0.03 | 0.25 | FALSE |
8 | GTEx | Cells EBV-transformed lymphocytes | ZNF543 | 0.38 | 0.07 | enet | 33 | 0.24 | 2.6e-08 | -2.8 | -5.5 | 4.3e-08 | -0.05 | 0.23 | 0.25 | FALSE |
9 | GTEx | Cells EBV-transformed lymphocytes | CTC-444N24.13 | 0.27 | 0.17 | lasso | 2 | 0.20 | 4.4e-07 | 5.2 | -5.1 | 3.0e-07 | -0.06 | 0.07 | 0.84 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | ZNF304 | 0.25 | 0.15 | lasso | 3 | 0.18 | 1.0e-13 | 4.8 | -5.3 | 1.4e-07 | -0.03 | 0.20 | 0.79 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | ZNF544 | 0.07 | 0.01 | enet | 13 | 0.04 | 6.8e-04 | 4.1 | -6.3 | 3.5e-10 | 0.56 | 0.04 | 0.87 | TRUE |
12 | GTEx | Colon Sigmoid | CTD-3138B18.5 | 0.24 | 0.00 | enet | 30 | 0.08 | 7.2e-04 | 3.8 | -6.0 | 2.6e-09 | 0.35 | 0.19 | 0.19 | FALSE |
13 | GTEx | Colon Sigmoid | AC007228.11 | 0.21 | 0.19 | lasso | 3 | 0.15 | 7.9e-06 | 5.3 | 5.3 | 1.3e-07 | 0.02 | 0.01 | 0.99 | FALSE |
14 | GTEx | Colon Transverse | CTD-2368P22.1 | 0.20 | 0.12 | lasso | 5 | 0.13 | 7.0e-07 | -6.0 | 5.1 | 2.8e-07 | -0.60 | 0.10 | 0.86 | FALSE |
15 | GTEx | Esophagus Gastroesophageal Junction | ZNF544 | 0.27 | 0.19 | enet | 18 | 0.20 | 6.5e-08 | 4.2 | -5.2 | 2.4e-07 | 0.20 | 0.85 | 0.01 | FALSE |
16 | GTEx | Esophagus Mucosa | CTD-2368P22.1 | 0.28 | 0.12 | lasso | 5 | 0.16 | 7.4e-11 | 3.8 | 5.2 | 2.2e-07 | -0.62 | 0.18 | 0.82 | FALSE |
17 | GTEx | Esophagus Muscularis | CTD-2368P22.1 | 0.36 | 0.08 | lasso | 4 | 0.10 | 1.6e-06 | -6.0 | 5.8 | 6.0e-09 | -0.64 | 0.15 | 0.84 | FALSE |
18 | GTEx | Lung | CTD-2368P22.1 | 0.15 | 0.10 | lasso | 6 | 0.14 | 1.6e-10 | -5.7 | 5.6 | 1.9e-08 | -0.74 | 0.05 | 0.95 | TRUE |
19 | GTEx | Lung | AC007228.11 | 0.12 | 0.07 | enet | 8 | 0.05 | 7.0e-05 | 5.3 | 5.3 | 1.1e-07 | 0.02 | 0.00 | 0.99 | FALSE |
20 | GTEx | Muscle Skeletal | ZNF587B | 0.06 | 0.01 | enet | 32 | 0.01 | 5.4e-02 | -6.2 | -5.7 | 1.3e-08 | 0.60 | 0.04 | 0.83 | TRUE |
21 | GTEx | Nerve Tibial | ZNF544 | 0.09 | 0.04 | enet | 10 | 0.02 | 9.1e-03 | -4.0 | -5.4 | 8.6e-08 | 0.12 | 0.60 | 0.02 | FALSE |
22 | GTEx | Pituitary | C19orf18 | 0.24 | 0.07 | lasso | 6 | 0.06 | 1.4e-02 | -6.2 | 5.5 | 5.1e-08 | -0.68 | 0.07 | 0.41 | TRUE |
23 | GTEx | Skin Not Sun Exposed Suprapubic | AC007228.11 | 0.22 | 0.01 | lasso | 6 | 0.03 | 8.9e-03 | 4.4 | 5.2 | 1.9e-07 | -0.01 | 0.01 | 0.98 | FALSE |
24 | GTEx | Skin Sun Exposed Lower leg | ZNF417 | 0.22 | 0.07 | enet | 48 | 0.11 | 3.0e-09 | -4.7 | 6.7 | 1.8e-11 | -0.46 | 0.68 | 0.32 | TRUE |
25 | GTEx | Skin Sun Exposed Lower leg | ZNF749 | 0.16 | 0.10 | lasso | 3 | 0.11 | 3.3e-09 | 4.6 | 5.3 | 1.0e-07 | -0.04 | 0.21 | 0.78 | FALSE |
26 | GTEx | Skin Sun Exposed Lower leg | ZFP28 | 0.19 | 0.13 | lasso | 9 | 0.17 | 1.1e-13 | 5.3 | 5.6 | 1.8e-08 | -0.01 | 0.01 | 0.99 | FALSE |
27 | GTEx | Spleen | AC007228.11 | 0.25 | 0.08 | enet | 23 | 0.07 | 6.0e-03 | -4.7 | 5.4 | 6.7e-08 | 0.00 | 0.03 | 0.81 | FALSE |
28 | GTEx | Testis | CTD-2583A14.8 | 0.60 | 0.41 | enet | 38 | 0.46 | 1.8e-22 | -4.4 | 5.2 | 2.6e-07 | -0.30 | 1.00 | 0.00 | FALSE |
29 | GTEx | Thyroid | AC007228.11 | 0.28 | 0.22 | lasso | 8 | 0.23 | 3.1e-17 | 5.3 | 5.2 | 2.5e-07 | 0.00 | 0.00 | 0.99 | FALSE |
30 | GTEx | Uterus | ZNF419 | 0.43 | 0.00 | lasso | 7 | 0.03 | 7.5e-02 | -4.8 | 5.8 | 6.4e-09 | -0.51 | 0.04 | 0.43 | FALSE |
31 | GTEx | Whole Blood | CTD-2368P22.1 | 0.17 | 0.04 | enet | 25 | 0.10 | 2.4e-09 | 3.4 | 5.2 | 2.5e-07 | -0.54 | 0.32 | 0.68 | TRUE |
32 | GTEx | Whole Blood | ZFP28 | 0.11 | 0.10 | enet | 12 | 0.09 | 2.5e-08 | 4.4 | 5.2 | 2.4e-07 | 0.00 | 0.15 | 0.82 | FALSE |
33 | METSIM | Adipose | ZFP28 | 0.13 | 0.09 | bslmm | 490 | 0.12 | 7.3e-17 | 5.0 | 6.5 | 6.0e-11 | -0.01 | 0.01 | 0.98 | TRUE |
34 | NTR | Blood | ZFP28 | 0.06 | 0.05 | lasso | 7 | 0.06 | 1.3e-18 | -4.7 | 5.6 | 2.7e-08 | -0.02 | 0.10 | 0.88 | FALSE |
35 | NTR | Blood | ZNF460 | 0.04 | 0.02 | bslmm | 507 | 0.02 | 9.5e-08 | -5.6 | -6.8 | 1.1e-11 | 0.09 | 0.00 | 1.00 | TRUE |
36 | YFS | Blood | ZNF470 | 0.04 | 0.02 | bslmm | 476 | 0.02 | 3.4e-07 | -4.7 | 5.3 | 1.2e-07 | -0.03 | 0.10 | 0.88 | FALSE |
37 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZFP28 | 0.02 | 0.01 | enet | 4 | 0.02 | 1.2e-04 | -4.7 | 5.2 | 1.9e-07 | -0.05 | 0.08 | 0.84 | FALSE |
38 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZNF470 | 0.05 | 0.02 | blup | 73 | 0.04 | 3.1e-03 | -4.2 | 5.7 | 1.1e-08 | -0.01 | 0.02 | 0.48 | FALSE |
39 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRAPPC2P1 | 0.05 | 0.02 | enet | 9 | 0.03 | 2.0e-04 | 3.7 | -5.7 | 9.3e-09 | 0.05 | 0.01 | 0.84 | FALSE |
40 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ZNF749 | 0.26 | 0.15 | enet | 6 | 0.18 | 6.0e-12 | 4.8 | -5.3 | 1.2e-07 | -0.02 | 0.01 | 0.98 | TRUE |