TWAS hub - SLC27A5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0280	2.4e-04	0.033	0.013	0.072	0.021	0.042	6.3e-05	9.6e-03	4.4e-09	1.1e-03	6.8e-06
2	GTEx	Artery Aorta	0.1500	0.0520	9.8e-05	0.041	NA	0.073	NA	0.109	2.5e-03	NA	7.2e-05	NA	1.3e-06
3	GTEx	Brain Hippocampus	0.1862	0.0756	2.9e-03	-0.011	NA	-0.007	NA	-0.004	7.0e-01	NA	5.2e-01	NA	4.1e-01
4	GTEx	Cells EBV-transformed lymphocytes	0.1970	0.0660	2.0e-04	0.186	NA	0.174	NA	0.196	1.1e-06	NA	2.6e-06	NA	5.4e-07
5	GTEx	Colon Transverse	0.0750	0.0330	3.6e-03	0.129	NA	0.092	NA	-0.001	1.1e-06	NA	3.7e-05	NA	3.4e-01
6	GTEx	Esophagus Mucosa	0.1150	0.0620	2.3e-03	-0.001	NA	0.012	NA	-0.001	3.9e-01	NA	4.6e-02	NA	4.0e-01
7	GTEx	Skin Not Sun Exposed Suprapubic	0.0730	0.0340	4.6e-03	0.086	NA	0.030	NA	0.055	1.9e-05	NA	8.7e-03	NA	5.5e-04
8	GTEx	Skin Sun Exposed Lower leg	0.0810	0.0290	6.1e-05	0.034	NA	0.086	NA	0.067	7.4e-04	NA	1.3e-07	NA	3.0e-06
9	ROSMAP	Brain Pre-frontal Cortex	0.0936	0.0257	8.9e-09	0.060	0.072	0.076	0.069	0.074	3.5e-08	1.3e-09	5.4e-10	2.8e-09	7.8e-10
10	TCGA	Colon Adenocarcinoma	0.0820	0.0500	1.6e-03	0.044	0.022	0.018	NA	0.019	1.4e-03	1.8e-02	3.1e-02	NA	2.7e-02
11	TCGA	Brain Lower Grade Glioma	0.0628	0.0327	9.0e-05	0.037	0.029	0.019	NA	0.033	4.8e-05	2.8e-04	2.7e-03	NA	1.2e-04
12	TCGA	Lung Squamous Cell Carcinoma	0.0236	0.0141	8.0e-03	0.011	0.014	0.015	NA	0.012	2.0e-02	9.1e-03	7.1e-03	NA	1.6e-02
13	TCGA	Thyroid Carcinoma	0.0580	0.0300	3.7e-03	0.006	0.019	0.001	NA	0.008	7.5e-02	5.6e-03	2.8e-01	NA	5.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Chronotype (morning person)	5.6	13.0	24.8	-3.1	-3.8	-1.7	-4.7	-5.0	-2.7	-3.5	-4.4	-3.5	-4.6	-2.0	-3.6	-2.3
Blood Platelet Count	5.2	59.7	98.6	7.7	7.4	7.1	9.1	9.1	4.7	4.5	7.7	9.9	9.2	8.2	9.5	2.2
Relative age voice broke	5.1	7.9	15.9	2.9	2.3	2.0	4.0	3.9	1.6	4.0	2.9	2.0	3.6	1.2	1.8	2.2
Relative age of first facial hair	4.5	9.2	22.6	2.0	3.0	1.0	4.3	4.5	1.6	4.8	3.4	1.5	4.1	0.9	1.8	2.5
Age when periods started (menarche)	4.3	10.3	23.4	3.0	3.4	1.2	4.7	4.8	1.9	4.3	2.2	1.8	4.2	0.5	2.3	3.5
Worry too long after embarrassment	3.6	6.0	16.8	3.6	2.2	1.2	3.1	2.9	-0.3	1.9	1.1	2.3	2.5	1.6	2.2	4.1
Eye problems/disorders: Cataract	3.4	4.0	9.1	-1.2	-1.6	-1.2	-2.5	-2.4	-1.2	-0.5	-1.9	-2.7	-2.5	-2.6	-3.0	0.0
Neuroticism (Nagel 2018)	3.3	7.7	22.8	3.9	3.7	0.5	3.1	2.7	1.4	2.1	0.9	2.8	3.1	1.6	2.1	4.8
Neuroticism	3.3	8.0	20.1	4.5	3.4	1.2	3.0	2.8	1.2	1.7	1.0	3.3	2.9	2.1	2.6	4.2
Sensitivity / hurt feelings	3.1	5.3	12.0	2.4	2.2	-0.5	3.3	3.0	1.7	3.5	1.9	0.9	2.9	0.6	0.8	3.1
Severe depression (siblings)	3.1	3.4	9.2	-1.4	-2.0	-2.3	-1.8	-1.5	0.3	0.3	-1.4	-2.6	-1.6	-2.7	-3.0	-0.0
Suffer from ‘nerves’	3.1	4.8	17.5	3.0	3.0	-0.2	2.2	2.2	0.8	1.3	0.7	2.1	2.4	1.1	1.5	4.2
Bipolar Disorder (2018)	3.0	4.7	14.9	-0.8	0.5	-3.1	0.5	0.8	2.8	3.0	0.7	-3.3	1.6	-3.9	-2.0	0.7
Worry (Nagel 2018)	3.0	6.4	14.9	2.9	3.3	0.4	3.1	2.9	1.5	2.7	1.5	2.3	2.9	1.1	1.6	3.9
Supplements: Zinc	2.9	3.1	8.9	-0.6	-1.9	-2.1	-0.9	-1.2	-0.2	0.8	-2.0	-3.0	-1.6	-2.7	-2.6	-0.5
Supplements: Vitamin C	2.8	3.3	8.9	-2.1	-1.2	-2.9	-0.9	-0.8	0.0	1.3	-1.0	-3.0	-1.1	-2.9	-2.6	-0.1
Ulcerative Colitis	2.7	3.9	11.6	-1.0	-1.6	-0.4	-2.8	-2.3	-2.4	-2.6	-3.4	-1.5	-1.9	-1.1	-1.5	0.8
Hearing difficulty/problems: Yes	2.7	4.1	10.3	1.1	2.6	3.1	1.6	1.1	-0.0	-1.2	0.6	3.0	1.9	2.4	3.2	1.0
Mood swings	2.7	4.8	9.5	2.8	2.7	0.5	2.2	2.0	1.9	1.0	0.2	3.1	2.4	2.2	2.2	2.9
Eye problems/disorders: Glaucoma	2.7	3.2	8.6	-0.7	-0.3	-0.3	-2.5	-2.8	-1.1	-2.7	-2.9	-1.4	-1.7	-1.2	-1.5	0.9
Bipolar Disorder or Schizophrenia	2.5	6.1	21.5	-2.3	1.2	-3.7	-0.2	-0.2	2.8	1.8	-0.5	-4.0	1.6	-4.6	-2.4	1.2
Intelligence (Savage-Jansen 2018)	2.5	7.7	29.4	1.4	3.3	-1.2	3.0	2.9	1.6	5.4	2.5	-1.1	3.1	-2.7	-0.8	3.4
Neuroticism score	2.5	5.2	15.9	3.2	2.9	0.4	2.4	2.3	0.8	1.2	0.6	2.6	2.2	1.8	2.2	4.0
Length of working week for main job	2.5	2.7	6.6	-0.7	0.2	0.3	-2.2	-2.1	-2.6	-1.0	-1.1	-2.2	-1.3	-2.0	-2.0	1.5
Osteoporosis (self-reported)	2.5	3.1	8.3	1.5	2.3	-0.8	1.7	2.2	2.1	2.9	0.8	-1.0	2.1	-1.5	-0.1	1.7
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.4	17.5	1.4	0.2	3.5	1.6	1.6	1.1	-0.2	1.7	3.7	1.2	4.2	2.9	-2.3
Ever taken oral contraceptive pill	2.4	2.7	6.3	-1.3	-1.6	-2.2	-1.0	-1.1	1.5	0.9	0.3	-2.5	-1.0	-2.2	-2.3	-1.7
Verbal and Numeric Reasoning (VNR)	2.3	5.5	21.5	1.3	2.3	-1.2	3.0	3.1	2.0	4.6	2.0	-0.4	2.8	-1.5	0.1	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	11.6	-0.7	1.1	-3.4	-0.4	-0.4	0.8	1.2	-2.1	-1.6	0.0	-2.8	-2.0	3.3
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	8.3	1.8	0.3	2.4	0.1	0.3	-1.1	-2.5	0.1	2.3	0.3	2.9	2.6	0.4
Depression (self-reported)	2.2	2.7	8.3	1.2	1.6	-1.2	2.1	2.2	1.7	2.9	1.2	0.2	1.7	-0.6	-0.0	2.0
Birth weight	2.2	4.7	13.0	2.9	2.0	3.6	1.8	1.5	-1.2	0.0	0.4	2.8	1.9	3.2	2.5	1.1
Breast cancer (self-reported)	2.2	2.6	4.5	-2.1	-1.3	-1.8	-1.9	-2.1	-0.4	-1.1	-1.2	-1.8	-1.9	-1.4	-1.7	-1.2
Supplements: Calcium	2.2	2.4	6.0	0.7	-0.3	-2.4	0.1	0.1	0.2	2.5	0.3	-2.4	0.2	-2.4	-2.4	1.1
Depressed Affect (Nagel 2018)	2.1	4.3	14.0	3.1	2.7	0.3	1.7	1.2	0.8	-0.1	-0.2	3.0	1.7	1.9	2.1	3.7
Hearing difficulty/problems with background noise	2.1	3.4	12.3	1.5	3.5	1.9	1.8	1.2	-1.3	0.2	0.4	1.7	1.9	0.8	2.0	2.9
Mouth/teeth dental problems: Loose teeth	2.1	2.5	6.1	-1.8	-1.7	-2.5	-1.0	-0.9	0.2	1.0	-1.0	-2.3	-1.1	-2.2	-2.0	-0.9
Friendships satisfaction	2.1	2.6	8.2	-2.9	-1.0	-1.0	-1.9	-1.8	-1.5	-1.2	-0.5	-1.5	-1.9	-1.6	-1.4	-1.5
Irritable Bowel Disease (IBD)	2.0	4.8	9.7	-2.9	-2.0	-1.1	-2.8	-2.3	-1.2	-1.0	-1.6	-3.1	-2.1	-2.7	-2.9	-1.0
Stomach or abdominal pain in last month	2.0	2.5	7.1	-1.5	1.6	-1.5	1.1	1.1	1.6	2.7	1.1	-1.4	1.4	-2.6	-1.0	0.8
Crohns Disease (2017)	1.9	4.1	10.1	-2.6	-1.7	-1.5	-2.2	-2.1	-0.9	-0.4	-0.8	-3.2	-2.0	-2.8	-2.8	-1.2
Nervous feelings	1.9	3.6	13.8	2.4	2.4	0.5	1.9	2.0	0.2	1.0	0.5	2.2	1.9	1.0	1.7	3.7
Birth weight of first child	1.9	3.4	7.2	2.0	1.1	2.5	2.4	2.1	-0.6	0.9	0.5	2.4	1.8	2.7	2.3	0.6
Eye problems/disorders: None of the above	1.9	2.2	5.4	0.4	0.6	-0.5	2.3	2.3	0.6	1.5	1.4	1.9	1.8	1.7	1.6	0.2
Major Depression (MDD)	1.8	2.2	7.4	-0.4	-1.0	-1.6	-0.8	-0.5	-0.3	1.0	-1.7	-2.4	-0.9	-2.7	-2.2	1.0
Coronary Artery Disease (CAD)	1.8	2.2	5.1	-2.2	-0.4	-2.3	-1.6	-1.4	0.8	-0.7	-0.6	-2.0	-1.0	-1.9	-1.5	-1.2
Vitamin and mineral supplements	1.8	2.4	7.0	-0.9	-0.3	1.6	-0.3	-0.6	-1.6	-2.6	1.0	1.6	-0.7	2.1	2.1	-2.2
Qualifications: CSEs or equivalent	1.8	2.4	6.9	-1.9	-0.4	-1.9	-2.1	-1.4	0.8	0.1	-0.4	-2.0	-1.4	-1.8	-2.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	8.2	-0.6	0.7	-2.9	-0.8	-0.8	-0.5	0.5	-1.4	-1.4	-0.5	-2.4	-1.9	2.6
Health satisfaction	1.8	2.3	5.0	-1.1	-2.1	-0.4	-2.2	-1.9	-1.7	-1.7	-1.8	-0.5	-2.1	0.5	-1.0	-1.1
Commuting to job workplace: Cycle	1.8	2.2	8.3	0.7	-1.4	-0.3	-1.8	-1.5	-1.7	-1.1	-2.9	-0.2	-2.1	0.2	-1.5	0.8
Number of treatments/medications taken	1.7	3.0	8.4	1.5	2.4	-1.2	1.5	1.9	1.7	2.9	0.6	0.3	2.3	-0.5	-0.1	2.6
Had other major operations	1.7	2.1	3.8	0.8	1.9	-1.1	2.0	1.8	1.7	1.9	1.6	1.0	1.5	-0.0	1.3	0.8
Fluid intelligence score	1.7	3.4	15.8	1.0	1.6	-0.2	2.6	2.4	1.0	4.0	0.9	-0.7	2.0	-1.3	-0.2	2.0
Medication: Lansoprazole	1.7	2.0	4.8	2.1	0.8	1.4	0.7	1.4	1.3	0.0	1.1	2.1	0.8	2.2	1.9	-0.5
Medication: Amlodipine	1.7	2.4	7.5	2.2	2.1	1.3	1.2	1.3	0.4	0.6	0.0	1.5	1.9	1.3	1.2	2.7
Wheeze or whistling in the chest in last year	1.7	3.0	6.3	-1.0	-0.7	-2.1	-2.2	-1.9	-0.5	-0.4	-2.2	-2.1	-1.8	-2.0	-2.5	1.1
Alcohol drinker status: Never	1.7	2.0	7.4	-1.4	0.6	-0.8	0.2	0.6	0.4	2.2	-0.1	-2.4	0.3	-2.7	-2.0	0.6
Ever smoked	1.7	2.9	13.5	0.2	1.0	-1.2	1.2	1.7	2.5	3.7	0.7	-0.4	1.7	-2.0	-1.0	1.8
Diabetes (father)	1.6	1.9	6.2	-1.8	0.4	-1.6	-0.3	-0.4	1.1	1.3	-0.7	-2.3	0.1	-2.5	-1.9	-0.4
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	12.0	0.0	1.6	0.2	1.8	1.8	0.9	3.5	1.8	-0.7	1.5	-1.6	-0.9	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	5.0	-1.9	-0.7	-1.8	-0.8	-0.9	2.2	0.4	-0.1	-1.4	-0.1	-1.7	-1.4	-1.4
Ulcerative Colitis (UC)	1.5	2.7	5.5	-2.0	-1.4	-0.6	-2.3	-1.7	-1.6	-1.0	-1.7	-2.1	-1.6	-1.7	-2.2	-0.0
Schizophrenia (2014)	1.5	3.4	11.0	-2.8	1.2	-2.4	-0.6	-0.9	1.2	0.4	-0.8	-3.0	1.0	-3.3	-1.7	1.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.3	0.3	-0.9	-1.3	-1.8	-1.4	-0.9	-0.3	-1.6	-1.2	-1.7	-1.1	-1.8	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	9.1	2.3	2.6	-0.1	1.5	1.4	0.4	1.3	0.3	1.0	1.2	-0.3	0.8	3.0
Smoking status: Previous	1.5	2.3	6.5	1.3	1.7	-0.5	0.7	1.2	1.8	2.5	-0.3	-0.7	1.7	-1.8	-1.0	2.2
Basal cell carcinoma (self-reported)	1.5	1.8	3.7	-0.9	-0.9	-1.3	-1.7	-1.9	0.0	-0.9	-1.3	-1.6	-1.7	-1.7	-1.5	-0.8
Bipolar Disorder (2011)	1.4	1.4	4.2	0.0	-0.5	-1.9	-0.4	-0.3	0.8	1.4	-0.0	-1.8	0.2	-1.9	-2.0	0.6
Medication for hormone replacement therapy	1.4	1.6	5.6	-1.0	-0.4	-1.9	-0.6	-0.2	1.0	1.4	-0.5	-2.0	-0.1	-2.4	-1.7	0.4
Serious illness, injury or assault to yourself	1.4	1.8	5.4	1.4	0.2	1.3	-1.8	-1.7	-1.4	-2.3	-1.5	0.9	-1.0	0.7	0.2	1.0
Multivitamins +/- minerals	1.4	1.7	4.3	1.1	0.1	-1.4	-0.3	0.0	1.4	1.8	-1.1	-1.4	0.1	-1.8	-2.1	1.9
High blood pressure (mother)	1.4	1.9	5.6	0.1	-1.5	-0.7	-1.1	-0.8	-1.2	1.2	-0.9	-2.1	-1.4	-2.1	-2.4	0.7
Past tobacco smoking	1.4	2.6	8.7	-0.8	-1.5	1.2	-0.9	-1.4	-2.1	-3.0	-0.1	0.4	-1.8	1.9	0.9	-2.3
Prospective memory result	1.4	1.7	4.2	-0.7	-1.1	-1.1	-2.1	-1.7	-0.4	-1.4	-1.9	-1.4	-1.1	-0.8	-1.5	0.8
Hair/balding pattern: Pattern 4	1.4	3.4	10.8	-0.3	-0.8	2.3	0.5	0.2	1.1	-0.4	3.0	2.3	0.9	3.3	1.8	-2.7
Angina	1.3	1.7	3.9	-1.0	-1.9	-0.5	-1.8	-1.4	0.3	-0.2	-0.9	-1.1	-1.9	-0.7	-2.0	-1.5
Trunk fat percentage	1.3	5.1	21.0	0.4	4.6	0.5	2.8	2.9	0.8	2.0	1.1	1.0	3.3	-0.2	1.7	2.9
Average weekly fortified wine intake	1.3	1.5	3.9	1.0	2.0	1.1	1.8	1.7	-0.2	0.9	1.0	0.1	1.5	-0.8	1.1	1.3
Alcohol usually taken with meals	1.3	2.1	6.3	-0.4	-1.6	-0.4	-1.8	-2.5	-1.6	-1.9	-1.9	-0.2	-1.8	0.4	-1.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	10.4	1.6	-0.2	3.0	0.7	1.0	0.0	-0.8	0.5	3.1	0.5	3.2	2.0	-1.1
Headache pain in last month	1.3	2.2	6.0	0.6	0.9	-1.7	-0.2	-0.1	-0.4	1.9	-1.2	-1.7	-0.2	-2.4	-2.2	2.4
Chronic bronchitis/emphysema (mother)	1.3	1.6	3.8	-0.8	-0.4	-2.0	-1.4	-1.9	-0.8	-1.2	-1.3	-1.2	-1.6	-1.2	-1.0	-0.1
Osteoarthritis (self-reported)	1.3	1.7	8.0	1.4	0.5	0.0	-1.7	-1.4	-1.2	-2.8	-1.6	0.6	-1.1	0.7	0.2	1.1
Financial situation satisfaction	1.3	1.6	3.6	-1.0	-1.9	-1.0	-1.8	-1.4	-0.1	-0.3	-0.9	-1.2	-1.6	-0.6	-1.9	-1.1
Irritability	1.3	2.1	5.7	1.9	1.9	-0.7	1.4	1.7	1.7	2.1	0.1	0.4	1.3	-0.6	0.1	2.4
Myopia	1.3	1.8	11.4	-0.7	0.4	0.4	1.2	1.2	0.2	3.4	1.0	-1.3	1.0	-1.6	-1.4	0.7
Schizophrenia (2018)	1.2	2.5	8.1	-2.3	1.1	-2.1	-0.6	-1.0	1.3	-0.1	-1.1	-2.5	0.8	-2.9	-1.5	1.0
Reaction Time	1.2	2.3	7.6	-0.2	-0.7	-0.2	-2.3	-1.8	-1.3	-2.8	-2.6	0.5	-1.9	0.6	-0.2	0.2
Blood White Count	1.2	8.7	16.9	2.6	3.3	1.7	3.7	3.8	1.5	2.5	2.4	4.1	2.9	3.0	3.4	1.9
Diabetes (mother)	1.2	1.5	4.0	-0.3	1.8	-1.1	1.2	1.1	1.4	2.0	0.9	-1.5	1.4	-1.3	-0.6	0.3
Illnesses of mother	1.2	1.5	5.4	0.0	-0.3	2.1	0.3	0.1	-0.8	-0.9	0.3	2.1	-0.1	2.3	1.5	-1.2
Tense / ‘highly strung’	1.2	2.0	7.9	1.7	1.5	-0.6	1.6	1.5	0.2	1.8	0.9	1.0	1.3	0.3	0.3	2.8
Glaucoma (self-reported)	1.2	1.4	4.7	0.4	-0.2	0.1	-1.7	-1.8	-1.1	-2.2	-1.8	-0.2	-1.1	0.2	-0.6	1.0
Gout (self-reported)	1.2	1.7	5.0	-1.2	1.3	-1.2	0.0	0.1	-0.2	1.4	-0.8	-1.8	0.4	-2.2	-1.3	2.2
Body fat percentage	1.2	4.9	21.6	0.2	4.7	0.5	2.5	2.6	0.8	1.9	1.0	1.1	3.3	-0.0	1.6	2.9
Angina (self-reported)	1.2	1.6	3.6	-1.0	-1.8	-0.3	-1.9	-1.4	-0.1	-0.4	-0.6	-1.0	-1.9	-0.6	-1.9	-1.4
Mean time to correctly identify matches	1.2	2.3	9.6	0.6	-0.3	0.6	-1.5	-1.3	-1.1	-3.1	-2.3	1.7	-1.0	1.9	0.9	0.5
Commuting to job workplace: Walk	1.2	1.3	4.4	-0.9	-0.9	0.6	-0.9	-1.2	-2.1	-2.1	-1.7	0.1	-1.1	0.6	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	5.6	1.2	2.4	1.1	1.1	1.2	0.5	2.3	0.4	-0.2	1.6	-1.1	-0.7	2.1
Miserableness	1.2	2.1	10.7	2.2	2.0	-1.8	0.5	0.5	0.1	-0.1	-1.5	0.9	0.4	-0.2	0.4	3.3
Body Mass Index (BMI) (2010)	1.1	1.5	5.1	-0.3	-0.4	0.6	1.3	1.3	2.3	1.7	0.9	0.2	1.0	1.0	0.4	-2.2
Heel T-Score	1.1	8.4	22.4	1.7	-0.7	4.2	-0.6	-0.8	-0.1	-4.5	-0.2	4.1	-0.6	4.7	3.6	-3.7
Trunk fat mass	1.1	4.9	19.4	0.4	4.4	1.2	2.7	2.8	0.7	2.1	1.3	1.1	3.3	0.1	1.7	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	8.2	1.3	2.5	0.9	0.7	1.0	-0.3	0.7	0.1	1.2	1.3	0.2	0.6	2.9
Happiness	1.1	1.3	3.6	-1.2	-1.9	-0.3	-1.2	-1.2	-0.7	-1.0	-0.6	-0.4	-1.8	0.0	-0.7	-1.8
Ever highly irritable/argumentative for 2 days	1.1	1.3	5.0	-0.2	0.7	-1.9	-0.7	-0.3	-0.6	0.3	-1.4	-0.9	-0.4	-1.7	-1.2	2.2
Loud music exposure frequency	1.1	1.3	4.1	1.5	1.3	0.3	0.9	1.1	0.2	0.9	1.7	0.6	1.3	0.3	0.6	2.0
Medication: Allopurinol	1.1	1.4	4.1	-0.6	1.0	-1.0	-0.1	0.1	0.2	1.6	-0.4	-1.6	0.5	-2.0	-1.6	2.0
Number of full sisters	1.1	1.4	4.0	-0.8	-1.6	0.6	-1.4	-1.3	-0.8	-1.5	-2.0	-0.9	-1.3	-0.2	-0.7	-0.8
Age started oral contraceptive pill	1.1	1.3	3.3	0.9	1.2	0.4	1.8	1.2	0.6	0.4	1.2	1.5	1.3	0.7	1.7	0.9
Lupus	1.0	1.5	4.9	-0.6	-2.2	-0.7	-1.7	-1.7	-0.4	-1.8	-0.5	-0.4	-1.3	0.9	-0.8	-1.1
Neuroticism (2016)	1.0	1.5	2.8	1.2	1.4	0.4	1.3	1.5	0.8	0.9	0.9	1.7	1.3	1.4	1.5	0.9
Blood Red Count	1.0	9.4	21.3	0.8	4.6	0.2	3.6	4.0	3.7	4.1	4.1	1.1	4.4	0.3	2.0	0.5
Hand grip strength (right)	1.0	2.8	11.5	1.0	0.4	3.4	1.0	0.9	0.6	-0.5	1.0	2.2	0.9	2.5	2.2	-1.9
Maternal smoking around birth	1.0	1.5	8.7	0.5	1.1	-1.9	0.6	1.0	3.0	1.3	0.4	0.0	1.6	-0.2	-0.0	0.6
Hair/balding pattern: Pattern 2	1.0	1.2	9.1	-0.5	-0.8	-3.0	-0.1	0.0	0.7	1.1	-0.4	-0.6	-1.1	-1.0	-1.2	0.2
Worrier / anxious feelings	1.0	1.9	10.8	2.0	1.6	0.5	1.2	1.4	-0.5	0.9	0.5	1.0	1.1	0.5	0.9	3.3
Whole body fat mass	1.0	4.0	17.7	0.1	4.2	1.1	2.4	2.5	0.6	1.8	1.1	1.1	3.0	0.3	1.6	2.1
Tinnitus: Yes, now most or all of the time	1.0	1.2	4.5	0.5	-0.8	0.9	-0.7	-0.8	-0.4	-2.1	-0.7	1.5	-0.7	1.8	0.8	-0.8
Fractured/broken bones in last 5 years	1.0	1.3	3.5	-1.3	-0.1	-1.1	-1.5	-1.9	-0.4	-0.5	-1.2	-1.2	-0.8	-0.6	-1.7	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.5	-0.5	-0.3	0.4	-1.0	-1.0	-1.3	0.5	-0.1	-1.1	-0.6	-1.3	-1.9	1.9
Breastfed as a baby	0.9	1.1	5.0	2.2	1.1	0.3	1.1	1.0	0.5	-0.0	0.3	1.0	1.1	0.8	1.1	1.5
Peak expiratory flow (PEF)	0.9	2.0	5.2	0.3	1.2	1.9	2.1	1.8	0.2	2.3	2.1	0.1	1.6	-0.4	0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.5	-1.6	0.5	-1.8	0.2	-0.0	1.4	0.7	1.9	-0.3	0.8	-0.5	-0.6	-0.5
Family relationship satisfaction	0.9	1.1	2.3	-1.4	-1.1	-0.9	-1.5	-1.4	0.3	-0.2	0.1	-1.0	-1.1	-0.7	-1.5	-0.9
Arm fat percentage (left)	0.9	3.7	19.2	-0.3	4.4	0.1	2.1	2.1	0.5	1.9	1.0	0.5	2.8	-0.4	1.1	2.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.6	0.2	-1.9	-0.2	-1.0	-1.0	-0.6	-0.9	-1.5	0.2	-1.9	0.9	-0.7	-0.5
Long-standing illness, disability or infirmity	0.9	1.4	7.1	2.5	1.4	0.2	0.1	0.7	0.4	0.5	-0.1	0.9	0.7	0.4	0.1	2.7
Ever had bowel cancer screening	0.9	1.0	6.2	0.2	1.6	-0.9	-0.2	-0.0	-0.3	-0.0	-0.6	-0.4	0.3	-1.7	-0.4	2.5
Medication for cholesterol	0.9	1.3	4.0	0.0	1.3	0.5	1.4	1.3	1.4	-0.3	0.2	0.9	1.1	1.2	2.0	-1.5
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.0	1.7	0.8	0.1	1.3	1.5	1.1	1.2	1.1	0.7	1.3	-0.2	0.7	1.4
Depression (Nagel 2018)	0.8	1.2	5.3	1.0	2.3	-0.5	1.1	0.9	1.3	0.9	0.1	0.6	1.5	-0.3	0.7	1.4
Breast Cancer	0.8	2.0	6.2	-2.5	0.5	-2.4	0.2	-0.2	0.6	1.8	-0.2	-1.8	0.1	-1.8	-1.7	0.7
Crohns Disease (2012)	0.8	1.3	3.6	-1.1	-0.8	-0.9	-1.3	-1.1	-0.0	-0.1	-0.8	-1.9	-0.9	-1.8	-1.8	-0.8
HDL Cholesterol	0.8	1.4	8.0	-0.6	-0.0	1.8	-1.0	-1.1	-2.8	-1.1	-1.0	-0.1	-1.0	0.1	-0.2	0.9
Primary Biliary Cirrhosis	0.8	1.1	2.5	0.0	1.2	0.7	1.3	1.6	0.5	0.8	1.2	1.0	1.4	0.6	1.4	0.4
Hypothyroidism (self reported)	0.8	1.9	6.8	-0.2	-0.4	-1.0	-1.7	-1.8	-0.3	-2.6	-2.2	0.2	-1.1	1.1	0.5	-1.7
Respiratory disease	0.8	1.8	5.4	0.5	1.1	-0.6	-1.5	-1.3	-1.5	-1.5	-2.3	-0.7	-0.5	-1.3	-0.5	2.2
Hand grip strength (left)	0.8	2.1	9.2	0.1	-0.3	3.0	0.2	0.0	0.4	-1.3	0.4	1.3	0.2	2.2	1.6	-2.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	5.1	0.1	-0.3	-1.5	-0.2	0.2	-0.9	0.3	-0.1	-1.3	-0.3	-1.5	-1.0	2.3
Medication: Atenolol	0.8	1.0	3.7	-0.7	-0.3	-0.4	0.4	0.5	1.0	1.9	1.2	-1.2	0.8	-1.5	-1.1	-0.1
Number of incorrect matches in round	0.8	1.3	5.0	0.2	-1.1	1.5	-1.1	-1.1	-0.4	-1.5	-0.7	1.4	-0.5	2.2	0.3	-0.9
Allergy	0.8	1.8	5.1	1.9	0.2	1.6	1.4	1.5	0.3	0.3	0.6	2.0	0.8	2.3	1.6	-0.3
Pain all over the body in last month	0.8	0.8	2.8	-0.9	-0.5	-0.7	-0.4	0.3	0.6	1.1	0.7	-1.5	-0.1	-1.7	-1.4	-0.1
Arm fat percentage (right)	0.8	3.1	16.1	-0.7	4.0	0.2	1.8	1.9	0.2	1.9	0.8	0.2	2.5	-0.6	0.7	2.3
Hair/balding pattern: Pattern 3	0.8	1.1	3.9	1.5	0.2	1.0	-0.3	-0.3	-1.8	-0.5	-2.0	0.1	-0.3	-0.6	-0.2	1.8
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.6	-1.0	-0.3	-0.9	-1.4	-1.0	0.6	-0.2	-0.8	-1.6	-0.6	-1.3	-1.3	-1.2
Medication for pain relief, constipation, heartburn	0.8	1.3	3.8	0.2	0.7	0.8	1.7	1.6	1.2	0.8	1.9	-0.1	1.6	-0.2	1.3	-0.7
Alcohol intake frequency.	0.8	1.8	4.5	-1.6	0.7	-2.1	0.5	0.6	1.3	2.0	1.6	-1.6	0.6	-1.7	-1.2	-0.3
Chest pain or discomfort	0.8	1.2	3.8	-1.2	0.5	-1.4	-0.3	-0.1	1.3	0.9	-0.4	-1.3	0.1	-2.0	-1.3	1.2
Age at last live birth	0.8	1.1	2.9	-0.2	-1.6	-0.2	-1.2	-1.0	-1.3	-0.9	-1.7	-0.7	-1.6	-0.6	-0.9	-0.5
Leg pain on walking	0.8	0.9	2.8	1.0	0.1	1.3	0.5	0.5	-0.9	-0.8	-0.4	1.5	-0.0	1.7	1.5	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	4.4	-0.8	-1.2	-0.2	-0.9	-0.5	0.5	-0.1	0.5	-1.2	-0.9	-0.6	-1.1	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	4.2	0.1	-0.1	-0.8	0.6	0.7	0.8	1.8	-0.9	-0.6	0.8	-0.6	-1.0	2.0
Asthma (self-reported)	0.8	1.6	3.3	-0.4	-0.6	-1.2	-1.5	-1.7	-0.6	-0.5	-1.5	-1.8	-1.0	-1.7	-1.7	1.0
Average weekly champagne plus white wine intake	0.8	1.1	3.2	-0.5	-1.4	0.7	-1.4	-1.8	-0.8	-0.8	-1.4	-0.4	-1.3	-0.2	-1.0	-0.7
Guilty feelings	0.8	1.3	9.5	0.5	2.1	-0.1	0.3	0.3	-0.1	0.5	0.0	0.2	1.0	-0.8	0.0	3.1
Mother’s age at death	0.8	1.0	2.5	1.3	-1.6	1.0	-0.4	-1.1	-1.4	-1.6	-1.1	-0.4	-0.8	0.5	0.1	0.2
Medication: Lisinopril	0.8	1.0	2.8	-0.5	1.2	1.1	1.1	1.2	0.2	1.1	1.7	0.5	1.2	0.7	0.9	-0.3
Leg fat percentage (left)	0.8	2.9	14.7	-0.5	3.8	0.8	1.5	1.8	0.2	0.9	1.0	1.2	2.5	0.4	1.4	2.1
Number of operations (self-reported)	0.8	1.2	5.0	0.3	2.2	-1.2	0.2	0.5	1.4	0.7	-0.1	-0.1	0.7	-1.1	-0.3	2.0
Risk taking	0.8	1.2	3.6	-1.2	-0.6	-1.3	-1.2	-0.9	0.2	0.0	-1.0	-1.9	-0.5	-1.7	-1.6	-0.1
Schizophrenia vs Biploar Disorder	0.7	1.0	3.2	-1.5	-0.1	1.2	-0.8	-1.0	-1.8	-1.8	0.4	-0.2	-0.6	-0.2	0.3	-0.2
Ovarian Cancer	0.7	0.9	2.6	0.4	1.2	0.9	1.3	1.1	-0.7	1.6	0.5	0.4	1.1	0.1	0.4	0.9
Age at First Birth	0.7	1.1	4.7	-0.3	-0.0	0.7	-1.0	-1.0	-2.0	-2.2	-0.9	-0.4	-1.1	-0.2	0.2	0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.9	3.3	0.8	-1.0	1.0	-0.3	-0.7	-1.8	-1.2	-1.6	-0.3	-0.6	0.5	0.1	0.0
Medication: Levothyroxine sodium	0.7	1.2	3.2	1.3	1.1	0.1	-0.3	-0.7	0.1	-1.8	-1.3	1.6	-0.3	1.5	1.5	-0.8
Hip circumference	0.7	2.9	11.7	0.0	3.4	1.1	2.2	2.1	0.5	2.1	1.1	0.4	2.6	-0.5	0.9	1.4
Time employed in main current job	0.7	0.8	3.8	0.7	0.7	0.6	-0.7	-0.5	-1.9	-0.8	-0.8	0.2	-0.3	0.6	-0.4	1.7
Father’s age at death	0.7	1.0	4.9	0.5	0.7	2.2	1.0	1.0	0.6	0.3	0.8	1.0	0.9	1.0	1.1	-0.3
Number of live births	0.7	1.0	2.7	0.6	1.0	-0.1	1.6	1.6	0.9	0.7	0.5	1.1	1.4	0.5	0.9	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	6.3	0.4	0.1	1.1	2.1	1.6	0.4	2.5	1.8	0.0	1.0	-0.3	0.5	-0.7
Pulse wave reflection index	0.7	0.8	3.0	-0.6	-1.0	-1.7	-0.2	-0.2	0.8	0.9	-0.9	-1.2	-0.4	-0.9	-1.3	-0.3
Medication: Paracetamol	0.7	1.1	3.6	-0.9	-0.3	-1.9	-1.3	-1.1	0.6	0.7	-0.7	-0.8	-0.9	-0.8	-1.7	-0.6
Leg fat percentage (right)	0.7	2.5	13.4	-0.2	3.7	0.8	1.3	1.7	-0.0	0.8	0.5	1.2	2.3	0.4	1.2	2.1
Comparative body size at age 10	0.7	1.9	5.1	1.0	2.3	-0.0	1.9	1.7	0.7	1.8	0.9	0.4	1.9	-0.4	0.8	1.4
Number of full brothers	0.7	0.9	3.7	-0.1	-0.1	-0.2	-0.8	-1.0	-1.0	-1.9	-1.9	-0.3	-1.0	-0.3	0.3	-0.4
Number of children fathered	0.7	0.7	1.9	0.2	1.4	0.6	1.1	0.5	-0.4	0.6	0.9	0.8	1.4	0.5	0.8	1.1
Medication: Ibuprofen	0.7	0.8	5.3	0.2	0.7	1.0	-0.1	-0.1	-0.9	0.9	-0.1	-0.5	0.5	-1.0	-0.9	2.3
Illnesses of father: Heart disease	0.7	1.0	3.8	-0.2	0.8	-2.0	0.5	0.5	1.9	0.8	0.6	-0.6	0.8	-0.9	-0.6	1.1
Back pain experienced in last month	0.7	1.0	4.5	0.8	0.6	2.1	0.6	0.5	0.5	-0.0	-0.1	1.3	0.5	1.6	1.0	-1.0
Illnesses of father: None of the above (group 1)	0.7	0.8	2.9	0.8	-0.8	1.7	0.4	0.4	-0.8	0.1	0.6	1.5	0.0	1.5	0.8	-0.6
Arm fat mass (left)	0.7	2.7	15.0	-0.5	3.9	0.9	1.8	1.7	0.1	1.4	0.9	0.4	2.4	-0.2	1.0	1.7
Wears glasses or contact lenses	0.7	0.8	4.0	1.2	-0.2	0.5	0.7	0.6	-0.9	1.3	-0.0	0.2	0.5	0.3	-0.5	2.0
Mean Putamen Volume	0.6	0.7	2.3	-0.4	-1.2	1.0	-0.8	-0.6	-0.4	-1.5	-0.6	0.9	-1.0	0.9	0.5	-0.4
Smoking Status	0.6	1.4	4.5	1.0	1.5	-1.0	1.1	1.4	2.1	1.5	0.3	0.5	1.4	-1.0	0.5	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	4.5	0.4	0.8	-2.1	0.3	0.1	0.8	0.8	-0.9	-0.2	0.4	-1.0	-0.4	0.9
High blood pressure	0.6	1.6	5.6	-0.4	1.5	0.5	1.1	1.1	0.2	2.4	1.6	-0.6	1.7	-1.2	-0.7	1.4
Supplements: Glucosamine	0.6	0.8	3.7	0.5	1.0	-0.6	0.3	0.3	-0.3	1.0	-0.3	-0.8	0.2	-1.5	-0.9	1.9
Forced vital capacity (FVC)	0.6	2.2	9.2	0.4	-0.7	3.0	1.4	1.4	-1.0	1.6	2.3	0.4	0.3	0.7	0.9	-1.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	4.0	-0.8	-0.4	-2.0	-0.7	-0.6	-0.8	-0.5	-0.8	-0.8	-0.2	-0.9	-0.7	0.4
Weight	0.6	3.0	10.3	0.2	3.2	2.0	2.1	2.1	0.3	1.9	1.5	1.1	2.4	0.6	1.2	0.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	9.8	0.4	0.0	3.1	1.5	1.3	-0.6	1.3	2.0	0.6	0.7	0.6	1.0	-1.5
Asthma	0.6	1.2	2.5	-0.4	-0.5	-1.1	-1.2	-1.5	-0.5	-0.6	-1.2	-1.6	-0.8	-1.6	-1.3	1.1
Arm fat mass (right)	0.6	2.6	13.3	-0.8	3.7	0.9	1.8	1.7	0.3	1.7	1.1	0.2	2.4	-0.2	0.7	1.4
High blood pressure (siblings)	0.6	0.9	4.8	1.4	0.0	0.1	0.3	1.0	-1.3	0.3	0.5	1.0	0.5	0.7	0.3	2.2
Emphysema/chronic bronchitis	0.6	0.7	2.9	0.0	0.5	-1.7	-0.9	-0.8	-0.1	-1.6	-0.5	-0.1	-1.0	-1.0	0.1	0.3
Leg fat mass (right)	0.6	2.5	13.1	-0.5	3.6	1.1	1.6	1.7	0.2	1.4	0.6	0.7	2.5	0.2	1.0	1.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.2	-0.7	-1.8	-0.4	0.6	0.4	0.4	1.0	1.1	-0.2	-0.6	-0.2	-0.4	-1.3
Average weekly red wine intake	0.6	0.8	2.9	-0.0	-1.7	0.9	-0.9	-1.0	-0.9	-1.5	-0.4	-0.1	-1.1	0.7	-0.0	-0.8
Commuting to job workplace: Public transport	0.6	0.8	3.2	-0.6	-0.9	1.6	-0.5	-0.5	-1.8	-0.6	-0.3	0.6	-0.8	0.9	0.1	-0.2
Medication: Paracetamol	0.6	0.9	3.0	-0.4	-0.0	-1.7	-1.1	-0.7	0.4	1.0	-0.7	-0.8	-0.8	-1.0	-1.6	-0.1
Ever depressed for a whole week	0.6	0.7	3.0	1.3	0.7	-0.5	0.3	0.5	-0.5	-0.2	-0.4	1.2	0.5	0.5	1.0	1.7
Unable to work because of sickness or disability	0.6	0.8	2.3	0.4	1.3	-1.5	-0.4	0.5	0.7	0.7	0.8	-0.7	0.2	-1.4	-0.6	1.1
Leg fat mass (left)	0.6	2.4	12.8	-0.6	3.6	1.2	1.5	1.7	0.1	1.3	0.8	0.7	2.4	0.2	1.0	1.5
Blood Eosinophil Count	0.5	3.6	11.9	2.2	0.6	3.3	0.8	1.3	-0.8	-0.7	-0.3	2.8	1.0	3.5	2.2	1.2
Height	0.5	9.2	37.8	3.4	0.1	6.2	2.9	2.9	-1.2	1.1	3.4	3.4	1.6	3.7	3.3	-1.3
Waist Hip Ratio (WHR)	0.5	2.4	6.7	-1.4	-1.3	0.7	-2.1	-1.7	-2.6	-1.4	-2.0	-1.1	-1.9	-0.2	-1.5	0.0
Allergy or Eczema	0.5	1.3	5.5	-2.3	-0.1	-0.6	-1.4	-1.2	-0.7	-0.3	-0.4	-1.0	-0.7	-1.8	-1.3	0.4
Medication: Co-codamol	0.5	0.6	1.8	-0.9	1.3	-0.6	0.2	0.4	-0.2	1.1	0.2	-0.8	0.7	-1.3	-0.3	0.8
Fed-up feelings	0.5	1.0	5.3	0.9	1.8	-0.7	0.1	0.1	0.3	-0.4	-0.9	0.9	0.6	0.4	0.5	2.3
Taking other prescription medications	0.5	0.7	1.6	1.1	0.7	-1.1	-0.6	-0.1	0.6	0.5	-1.0	-0.9	0.1	-1.3	-0.9	1.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.5	0.4	0.7	-0.5	1.1	0.7	1.1	0.8	1.2	0.2	0.9	0.0	0.4	-0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	2.1	-0.0	1.2	0.0	-0.6	-0.4	-0.4	-0.6	-1.4	-0.6	-0.2	-1.2	-0.1	0.9
Waist circumference	0.5	1.8	7.5	-0.5	2.7	1.5	1.3	1.4	-0.5	1.6	0.4	0.4	1.9	0.1	0.3	1.9
Qualifications: None of the above	0.5	1.1	4.2	-0.8	0.3	-2.0	-0.8	-1.2	0.1	-1.8	-1.9	0.3	-0.5	0.4	0.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	8.2	0.7	0.4	2.9	1.5	1.2	-0.9	1.2	1.7	0.6	0.8	0.5	0.9	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.0	0.6	0.2	-0.3	-0.6	-0.8	0.3	-1.7	-1.5	0.9	-0.3	1.4	1.1	-1.3
Forced vital capacity (FVC), Best measure	0.5	1.8	10.6	1.0	0.1	3.3	1.4	1.1	-1.3	1.0	1.9	0.6	0.5	0.7	1.0	-0.4
Pulse wave peak to peak time	0.5	0.5	2.7	0.8	0.7	1.6	-0.1	-0.2	-0.6	-0.8	0.6	0.1	0.7	0.1	0.4	1.2
Shortness of breath walking on level ground	0.5	0.6	2.3	0.6	1.4	-0.2	-0.1	0.2	-0.0	-0.4	-1.2	0.8	0.4	0.3	0.5	1.5
Medication: Seretide 50 evohaler	0.5	0.6	2.9	-0.5	0.2	-0.6	-0.8	-0.3	0.9	0.0	-0.1	-1.7	0.1	-1.3	-0.6	-0.3
Loneliness, isolation	0.5	0.7	6.8	0.5	0.6	-0.6	0.1	-0.1	0.1	0.5	-0.1	0.5	0.3	0.6	-0.6	2.6
Diabetes diagnosed by doctor	0.5	0.9	3.0	-0.5	-1.1	-0.7	-0.9	-0.8	0.3	0.9	-0.2	-1.3	-1.2	-0.4	-1.7	-1.1
Qualifications: nursing, teaching	0.5	0.8	3.2	0.5	-1.4	1.5	-0.2	-0.0	-1.8	0.3	0.6	0.4	-0.8	0.6	-0.2	-0.8
Mineral and other dietary supplements	0.5	0.7	3.0	-1.7	-0.2	-0.1	-0.8	-0.9	-0.2	-1.2	-0.5	0.0	-0.6	0.5	0.1	-1.3
Medication: Gliclazide	0.5	0.6	2.3	0.6	-1.5	0.2	-0.5	-0.1	-0.3	-0.2	0.8	0.3	-1.2	0.7	-0.0	-1.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.9	1.3	1.7	0.7	0.5	0.5	-0.1	0.1	-0.4	0.7	0.7	0.4	0.6	1.3
Vascular/heart problems diagnosed by doctor	0.5	1.2	4.6	-0.0	-1.3	-0.2	-0.9	-1.1	-0.7	-2.2	-1.2	0.4	-1.6	0.9	0.6	-1.3
Pain experienced in last month	0.5	0.8	3.6	0.0	-0.3	0.5	0.8	1.0	-0.3	-0.4	1.9	0.7	0.9	0.9	1.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.2	-1.5	1.1	-0.9	-0.6	-0.6	-0.5	-1.1	0.0	-0.8	0.0	-0.9	0.3	-0.5
Fasting Glucose	0.4	0.4	3.2	0.2	-0.2	0.4	-0.6	-0.1	0.0	-0.3	1.0	-0.6	-0.4	0.5	-0.3	-1.8
Triglycerides	0.4	0.7	2.7	-0.6	0.0	-0.0	0.8	1.2	1.6	0.4	0.6	0.6	0.8	0.4	1.0	-1.2
Cardiovascular Disease	0.4	1.4	4.6	0.9	1.0	0.1	1.4	1.6	0.5	2.1	1.2	0.1	1.7	-0.4	-0.2	1.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	3.0	0.7	1.7	-1.1	0.2	0.2	0.5	0.1	-0.0	0.6	0.5	-0.6	0.2	1.4
Current tobacco smoking	0.4	0.7	2.7	0.1	-0.5	-1.4	-0.1	-0.1	0.3	-1.0	-0.5	1.6	-0.7	0.9	1.1	-0.5
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.3	-1.5	-0.2	-0.8	-0.8	-0.6	-0.4	0.3	0.0	-1.4	-0.4	-1.8	-1.3	0.4
Body mass index (BMI)	0.4	1.8	10.2	-1.2	3.2	0.3	1.2	1.2	0.5	1.4	0.9	0.1	2.0	-0.4	0.4	0.9
Had menopause	0.4	0.5	1.2	1.0	0.6	-0.2	0.6	0.5	1.1	-0.6	0.3	1.0	0.6	0.7	1.0	0.4
Medication: Ramipril	0.4	0.6	1.6	-0.5	0.2	-1.1	-0.0	-0.1	0.4	1.2	-0.2	-0.6	-0.0	-1.2	-1.3	0.8
Pulse rate	0.4	0.7	2.4	-0.1	1.6	0.7	0.7	0.7	-1.1	-0.5	-0.1	1.2	0.0	0.4	1.4	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	3.5	-0.1	1.9	0.1	0.3	0.4	0.6	-0.1	-0.4	-0.0	1.0	-0.8	0.6	-0.1
Medication: Cholesterol lowering	0.4	0.7	3.0	1.0	-0.1	0.1	0.5	0.7	0.1	-0.2	-0.6	1.3	0.5	1.7	1.0	0.6
Lung cancer (father)	0.4	0.4	1.6	0.1	-0.9	0.6	0.1	0.3	0.4	0.3	1.1	0.1	-0.0	1.1	0.0	-1.3
Pulse wave Arterial Stiffness index	0.4	0.4	1.7	-0.8	-0.7	-1.3	0.1	0.2	0.3	0.6	-0.7	0.1	-0.7	-0.0	-0.2	-1.2
Impedance of arm (left)	0.4	1.8	6.6	2.1	1.1	-0.8	1.5	1.7	0.7	1.1	0.6	0.7	1.1	-0.5	1.0	2.6
Exposure to tobacco smoke at home	0.4	0.4	1.3	0.3	0.3	1.0	0.6	1.0	0.3	1.1	0.5	-0.3	0.9	-0.4	0.1	0.5
Blood clot in the leg (DVT)	0.4	0.5	1.8	-1.1	1.3	-0.7	-0.4	-0.3	-0.5	-1.1	-0.0	-0.3	0.1	-0.6	0.6	-0.3
Qualifications: College or University degree	0.4	1.4	8.1	1.2	-0.4	2.9	1.0	0.4	-1.9	-0.0	-0.0	0.6	-0.1	1.1	1.3	-0.8
Hypertension (Self-reported)	0.4	1.2	3.4	-0.7	1.2	0.3	0.6	0.5	-0.3	1.9	0.7	-1.0	1.2	-1.6	-1.1	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	2.2	-0.0	-0.4	0.7	0.0	0.1	-0.4	-0.6	-0.1	0.6	-0.4	1.5	0.6	-1.2
Smoking status: Current	0.4	0.6	2.7	-0.3	-0.5	-1.7	-0.1	-0.1	0.5	-0.8	-0.5	1.4	-0.5	0.5	1.0	-0.5
Medication: Bendroflumethiazide	0.4	0.6	2.1	1.0	-0.5	1.4	-0.5	-0.7	-1.1	-0.5	-0.3	0.6	-0.7	0.7	-0.3	-0.8
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.5	0.3	0.0	0.8	0.6	0.3	-1.1	-0.6	-0.8	1.1	0.1	0.3	1.2	0.3
Alzheimer’s Disease (in mother)	0.3	0.3	1.7	-0.3	-0.4	0.3	-0.8	-0.8	-1.3	-0.8	0.1	0.0	-0.5	-0.0	-0.2	0.4
HbA1C	0.3	0.4	2.8	0.2	-0.3	0.1	0.6	0.6	0.3	0.8	1.7	0.0	0.3	0.5	-0.3	-0.6
Rheumatoid Arthritis	0.3	0.4	1.2	-1.1	0.6	0.1	0.4	0.4	-0.8	-0.3	0.9	0.4	0.8	0.8	0.9	-0.2
BMI	0.3	1.7	9.3	-0.9	3.0	0.1	1.4	1.4	0.5	1.4	0.8	0.4	2.0	0.0	0.6	1.1
Lung FVC	0.3	1.3	8.3	-0.5	-1.3	2.9	-0.1	-0.0	-0.9	0.0	1.4	0.1	-0.3	0.7	0.2	-1.9
Systolic blood pressure, automated reading	0.3	0.9	2.8	-1.7	0.9	1.0	0.8	0.8	-1.5	0.2	1.6	-0.1	0.8	-0.1	0.7	-0.3
Pack years adult smoking proportion	0.3	0.4	1.4	-0.3	0.1	-1.2	-0.3	-0.1	1.1	-0.3	-0.4	0.9	-0.2	1.2	0.5	-0.4
Leg fat-free mass (left)	0.3	1.6	4.6	-0.1	1.8	2.1	1.5	1.4	0.0	2.0	1.4	0.3	1.8	0.4	0.2	-0.1
Sitting height	0.3	2.2	10.1	1.2	-0.2	3.2	1.3	0.9	-0.6	-0.1	1.5	1.8	0.4	1.8	1.8	-1.6
Leg predicted mass (left)	0.3	1.6	4.4	-0.2	1.8	2.1	1.4	1.4	0.0	2.0	1.4	0.3	1.7	0.4	0.2	-0.1
Financial difficulties in last 2 years	0.3	0.4	1.2	-1.0	0.9	-1.1	-0.6	-0.5	0.1	-0.6	-0.7	-0.4	0.2	-0.0	-0.1	0.2
Diabetes (self-reported)	0.3	0.5	1.6	-0.5	-1.0	-0.9	-0.9	-0.6	0.3	0.5	-0.2	-0.4	-1.1	0.1	-1.2	-0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	-0.1	0.2	-0.4	-0.4	-0.4	0.9	1.0	0.1	-1.2	0.3	-0.8	-0.9	0.6
Illnesses of siblings	0.3	0.4	2.3	-0.2	0.3	0.6	0.4	-0.1	1.1	-0.3	-0.0	0.2	0.0	0.2	0.8	-1.5
Impedance of arm (right)	0.3	1.3	7.5	1.5	0.5	-1.1	1.0	1.1	0.3	1.4	0.3	-0.1	0.6	-1.1	0.0	2.7
Falls in the last year	0.3	0.4	1.6	0.5	1.3	-0.8	-0.1	0.2	1.2	-0.3	-0.1	-0.0	0.8	-0.2	0.4	0.6
Mouth/teeth dental problems: Dentures	0.3	0.4	1.9	-1.0	0.3	-1.4	-0.3	-0.5	0.6	-0.4	-0.1	-0.6	-0.1	-0.9	-0.4	-0.6
Standing height	0.3	3.4	13.4	2.5	0.5	3.7	2.0	2.0	-0.1	1.4	1.4	1.9	1.2	1.7	1.8	-0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.0	0.5	0.2	0.8	-0.3	-0.2	-0.9	-0.3	-0.7	-0.5	0.1	-0.6	-0.4	1.0
Age at first live birth	0.3	0.6	2.2	0.2	-0.9	1.1	-0.8	-0.5	-1.5	-0.6	-1.0	-0.0	-1.1	0.1	-0.1	-0.4
Migraine (self-reported)	0.3	0.4	1.2	0.9	1.0	-1.1	0.4	0.3	0.1	0.9	0.2	0.3	0.3	-0.1	-0.4	1.1
Pulse rate, automated reading	0.3	1.0	5.3	-0.1	1.2	2.3	0.2	0.4	-2.0	-0.1	-0.2	0.8	-0.2	-0.1	0.6	0.7
Comparative height size at age 10	0.3	1.6	4.6	0.9	-1.6	2.1	-0.7	-0.8	-0.9	-1.6	-0.5	0.9	-1.1	1.7	0.6	-1.9
Had major operations	0.3	0.4	1.6	0.5	0.8	0.5	-1.0	-0.4	0.6	-0.7	-1.3	-0.3	0.0	-0.2	-0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	3.8	0.6	-0.1	0.1	-0.0	0.1	0.0	0.7	1.9	0.1	-0.0	0.3	-0.4	-0.4
Medication: Aspirin	0.3	0.4	1.2	0.2	-1.0	-1.1	-0.6	-0.7	-0.1	0.1	-0.2	-0.5	-0.9	-0.0	-1.0	-0.1
Knee pain experienced in last month	0.3	0.4	1.3	-0.0	0.8	-0.7	-0.5	-0.6	0.6	0.4	-1.1	-0.3	-0.1	-0.6	-1.1	0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.7	-0.1	0.2	0.0	0.4	0.3	0.3	1.1	1.3	0.6	0.5	0.3	-0.6	1.0
Leg fat-free mass (right)	0.3	1.4	4.5	-0.3	1.5	2.1	1.2	1.1	0.0	1.7	1.5	0.3	1.5	0.4	0.2	-0.3
Leg predicted mass (right)	0.3	1.4	4.1	-0.3	1.5	2.0	1.2	1.1	0.1	1.8	1.5	0.2	1.6	0.4	0.1	-0.3
Number of self-reported non-cancer illnesses	0.3	0.5	3.0	0.2	1.7	0.6	0.3	0.3	0.7	0.1	-0.0	0.0	1.2	0.2	0.8	0.9
Medication: Blood pressure	0.3	0.6	2.2	-0.1	-0.3	0.2	-0.8	-0.9	-1.5	0.2	0.2	-0.2	-0.6	-0.5	-1.3	1.4
Medication: Atorvastatin	0.3	0.3	1.5	-0.7	0.3	-0.8	-0.7	-0.3	-0.4	-0.4	-1.2	-0.1	-0.6	-0.2	-0.2	0.4
Basal metabolic rate	0.3	1.4	6.6	-0.2	1.4	2.6	1.1	1.1	-0.1	1.3	1.4	0.7	1.3	0.9	0.5	-0.6
Diastolic blood pressure, automated reading	0.3	1.0	2.7	-1.3	1.6	1.6	0.9	0.8	-0.7	0.1	0.9	-0.5	1.2	-0.6	1.0	-0.4
Cholesterol lowering medication	0.3	0.4	2.0	0.2	-0.1	0.7	-1.0	-1.0	-0.2	-1.4	-0.2	0.5	-0.5	0.6	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.6	1.1	0.5	-0.5	0.2	0.3	1.3	0.6	-0.4	-0.0	0.5	0.2	-0.3	0.1
Alzheimer’s Disease (in father)	0.2	0.2	1.5	0.7	0.2	-0.7	0.1	0.0	0.1	0.3	0.4	-0.2	0.1	-0.5	-0.1	1.2
Alzheimer’s Disease (including proxy)	0.2	0.4	1.2	-0.0	-0.6	-0.1	-0.8	-0.8	-1.1	-0.5	0.1	-0.3	-0.5	-0.4	-0.3	1.0
LDL Cholesterol	0.2	0.3	1.2	0.1	0.3	-0.3	0.8	1.1	0.3	-0.0	-0.1	0.3	0.4	0.8	1.0	0.1
Hair Pigment	0.2	4.4	15.1	1.5	0.3	2.3	1.7	1.3	1.3	-0.9	1.2	3.5	1.5	3.9	2.9	-1.5
Average weekly spirits intake	0.2	0.3	1.4	-1.0	-0.0	0.0	-0.2	-0.4	1.2	-0.6	0.4	0.2	0.3	-0.1	0.1	-0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.2	-0.4	0.1	0.0	0.0	0.8	-0.2	0.1	0.8	0.1	0.8	0.1	0.6
Medication: Metformin	0.2	0.3	0.8	0.5	0.8	-0.8	0.0	0.3	0.6	0.6	0.7	-0.0	0.2	0.0	-0.4	0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.1	0.2	0.1	-0.1	0.3	0.6	0.2	0.4	-0.5	0.7	0.2	1.1	0.1	0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	-0.3	0.9	-0.1	-0.4	-0.2	-0.2	-0.7	-0.6	-0.3	0.1	-0.6	0.0	0.8
Mouth/teeth dental problems	0.2	0.3	1.2	0.1	-0.5	-0.1	0.3	0.3	-0.0	-0.1	0.1	0.8	-0.2	1.1	0.8	-0.6
Heart attack	0.2	0.3	1.4	0.9	0.6	-0.8	0.0	0.1	1.2	0.5	-0.2	-0.0	0.4	0.1	-0.3	0.1
Medication: Simvastatin	0.2	0.3	1.5	0.5	-0.4	0.3	-0.0	-0.0	-0.2	-0.8	0.2	0.8	0.2	1.2	0.8	0.6
Trunk fat-free mass	0.2	1.3	8.6	0.1	0.4	2.9	0.6	0.6	-0.1	0.5	1.0	1.2	0.7	1.5	0.6	-1.3
Alcohol intake versus 10 years previously	0.2	0.2	0.5	-0.1	-0.5	-0.4	-0.5	0.0	0.7	0.6	-0.5	0.5	-0.3	0.7	-0.7	-0.4
Noisy workplace	0.2	0.2	0.8	-0.1	-0.6	0.2	-0.3	-0.5	-0.4	-0.9	-0.2	0.0	-0.5	0.5	0.1	-0.5
Trunk predicted mass	0.2	1.3	8.7	0.1	0.3	3.0	0.6	0.6	-0.2	0.6	1.0	1.1	0.6	1.4	0.6	-1.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.3	-0.3	-0.6	-0.1	-0.9	-0.7	-0.6	-0.7	-0.3	-0.5	-1.1	-0.7	-0.4	-0.5
Arm fat-free mass (right)	0.2	1.2	8.0	-0.2	0.9	2.8	0.8	0.6	-0.4	0.5	1.0	0.8	0.9	1.1	0.6	-0.9
Exposure to tobacco smoke outside home	0.2	0.2	1.9	0.2	-0.3	0.3	0.2	0.0	1.4	-0.2	-0.2	-0.1	0.5	-0.1	0.1	-0.5
Neck or shoulder pain in last month	0.2	0.2	2.4	0.3	0.4	0.1	0.3	0.1	1.6	0.3	-0.2	0.1	0.1	-0.3	-0.1	-0.3
Medication: Omeprazole	0.2	0.2	1.3	-0.2	0.1	-0.1	-0.2	0.3	-0.8	-0.6	-1.1	0.5	-0.3	0.3	0.6	0.2
Arm predicted mass (right)	0.2	1.0	6.7	-0.2	0.9	2.6	0.6	0.5	-0.2	0.4	0.6	0.8	0.8	1.0	0.5	-0.9
Overall health rating	0.2	0.4	2.9	-0.3	1.1	-0.1	-0.1	0.2	-0.4	0.6	0.3	0.4	0.3	0.3	-0.4	1.7
Whole body fat-free mass	0.2	1.4	7.6	-0.0	1.0	2.8	1.0	1.0	-0.1	1.2	1.4	0.8	1.2	1.1	0.5	-0.7
Medication: Aspirin	0.2	0.3	1.5	0.2	-0.5	-1.2	-0.2	-0.4	0.5	-0.0	0.1	0.1	-0.5	0.6	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.0	0.0	-0.5	1.0	0.7	0.5	-0.6	0.8	0.7	0.2	0.2	0.3	0.3	-0.5
Whole body water mass	0.2	1.2	7.4	-0.2	0.8	2.7	0.8	0.7	-0.3	0.9	1.2	0.7	1.0	1.1	0.4	-0.9
Hearing aid user	0.2	0.2	1.1	0.2	-0.5	0.2	0.2	0.1	1.1	-0.2	0.1	0.8	0.1	0.3	0.6	0.0
High cholesterol (Self-reported)	0.2	0.4	1.9	0.5	-0.2	1.0	0.3	0.3	-0.2	-0.5	0.2	1.1	0.5	1.4	0.8	0.3
Illnesses of father: High blood pressure	0.2	0.3	1.2	1.1	0.1	0.4	0.0	-0.3	-0.3	-0.6	-1.0	0.7	-0.2	0.3	0.7	0.0
Arm fat-free mass (left)	0.2	0.8	6.4	-0.7	0.8	2.5	0.4	0.3	-0.7	0.2	0.8	0.5	0.5	0.9	0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.9	-0.3	1.0	-0.4	0.1	0.6	-0.3	0.2	-0.4	0.2	0.1	-0.3	0.3	0.6
Heart disease (siblings)	0.2	0.3	1.0	0.2	-1.0	0.3	-0.4	-0.5	-0.3	-0.6	-0.4	-0.4	-0.4	-0.0	-0.1	-0.9
Alcohol drinker status: Previous	0.2	0.2	0.8	-0.2	0.1	-0.2	0.0	-0.2	0.9	0.2	0.9	0.3	0.3	0.4	-0.3	-0.2
Pack years of smoking	0.2	0.3	1.9	-0.2	0.1	-1.4	-0.1	0.0	1.2	0.0	-0.4	0.5	-0.1	0.8	0.3	-0.1
Impedance of whole body	0.2	1.2	5.3	1.9	0.7	-0.7	1.1	1.3	0.6	0.4	0.3	0.4	0.6	-0.6	0.9	2.3
Arm predicted mass (left)	0.2	1.1	7.5	-0.4	0.8	2.7	0.6	0.6	-0.4	0.4	1.1	0.7	0.7	1.1	0.5	-0.9
Prostate Cancer	0.1	0.2	0.7	0.3	0.8	-0.1	0.8	0.3	0.5	0.5	0.1	-0.2	0.6	-0.4	0.0	0.1
Systolic Blood Pressure	0.1	0.5	2.1	-0.9	0.3	0.6	0.6	0.8	-1.4	0.1	1.3	-0.1	0.5	-0.0	0.6	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.2	-0.6	-0.2	-0.5	-0.4	0.5	0.4	0.5	0.2	-0.6	0.6	-0.7	-0.3
Lung FEV1/FVC ratio	0.1	0.5	1.3	-0.5	0.9	0.9	0.3	0.5	0.1	-0.1	-0.3	1.1	0.9	1.1	0.3	0.7
Tanning	0.1	1.2	2.9	0.3	-0.1	0.6	-1.3	-1.6	-1.2	-1.7	-1.7	-0.5	-1.1	-0.1	-0.6	1.2
Impedance of leg (right)	0.1	0.3	1.1	1.0	-0.5	-0.5	-0.2	0.2	0.2	-0.8	-0.6	0.4	-0.5	-0.1	0.5	0.9
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.2	0.2	-0.8	-0.8	-0.4	0.8	-0.5	-0.2	0.1	-0.2	0.2	-0.2	-0.0
Impedance of leg (left)	0.1	0.3	1.1	1.0	-0.3	-0.3	-0.1	0.3	0.4	-0.9	-0.1	0.5	-0.3	0.0	0.7	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.7	0.5	0.2	-0.1	0.1	-0.4	-0.2	-0.3	-0.8	0.4	0.1	-0.0	0.3	0.5
Medication: Blood pressure	0.1	0.2	0.9	-0.4	0.2	-0.5	0.4	-0.1	0.6	0.9	0.4	-0.5	0.6	-0.2	-0.6	-0.4
Heart disease (mother)	0.1	0.2	0.8	0.3	0.2	-0.2	0.5	0.9	0.3	0.3	-0.5	0.5	0.3	0.1	0.4	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	0.6	0.0	0.1	0.5	0.2	-0.8	0.4	-0.1	-0.2	-0.2	-0.5	0.2	-0.3
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.5	-0.3	-0.3	-0.7	-0.3	-0.5	0.0	-0.4	-0.4	-0.2	-0.3	-0.6	0.6

Hub : Genes

SLC27A5

Models

Trait associations