Hub : Genes

ZNF543

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0590 0.0260 0.00910 0.027 0.017 0.041 0.028 0.034 2.7e-04 3.6e-03 8.4e-06 2.1e-04 4.3e-05
2 GTEx Artery Tibial 0.0834 0.0313 0.00160 0.000 NA 0.009 NA 0.006 3.4e-01 NA 6.0e-02 NA 9.5e-02
3 GTEx Cells EBV-transformed lymphocytes 0.3840 0.1190 0.00081 0.073 NA 0.238 NA 0.142 2.3e-03 NA 2.6e-08 NA 2.3e-05
4 GTEx Colon Transverse 0.1670 0.0650 0.00930 -0.006 NA -0.006 NA -0.006 8.2e-01 NA 7.9e-01 NA 8.9e-01
5 METSIM Adipose 0.0428 0.0191 0.01100 0.044 0.002 0.049 0.024 0.046 3.2e-07 1.5e-01 7.0e-08 1.2e-04 1.7e-07
6 YFS Blood 0.1263 0.0210 0.00000 0.140 0.116 0.142 0.139 0.145 2.0e-43 6.1e-36 4.2e-44 3.1e-43 4.9e-45
7 TCGA Breast Invasive Carcinoma 0.0286 0.0126 0.00047 0.022 0.019 0.020 NA 0.024 2.3e-05 5.7e-05 5.4e-05 NA 7.4e-06
8 TCGA Brain Lower Grade Glioma 0.0582 0.0300 0.00440 0.009 0.012 0.008 NA 0.016 3.0e-02 1.4e-02 3.7e-02 NA 4.9e-03
9 TCGA Lung Adenocarcinoma 0.0658 0.0275 0.00013 0.031 0.036 0.035 NA 0.045 1.3e-04 4.6e-05 5.3e-05 NA 5.2e-06
10 TCGA Lung Squamous Cell Carcinoma 0.0913 0.0473 0.00340 0.027 0.009 0.014 NA 0.011 3.8e-04 2.7e-02 8.5e-03 NA 1.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.1 0.2 0.5 0.1 -0.5 -0.0 0.3 0.0 -0.3 -0.2 0.7 -0.5 -0.6
Bipolar Disorder or Schizophrenia 0.3 0.7 4.2 0.4 0.2 0.9 0.3 0.4 -0.9 0.4 2.0 -0.7 -0.6
Depressed Affect (Nagel 2018) 0.0 0.1 0.4 0.2 0.6 0.1 -0.2 -0.1 0.2 -0.2 0.2 -0.2 0.7
Depression (Nagel 2018) 0.1 0.2 0.5 -0.1 -0.3 0.2 -0.6 -0.7 0.7 -0.5 -0.4 0.4 -0.1
Intelligence (Savage-Jansen 2018) 0.1 0.4 2.8 -0.0 0.4 0.2 -0.5 0.3 0.5 1.7 -0.1 0.7 0.1
Neuroticism (Nagel 2018) 0.1 0.3 0.7 0.6 0.1 0.9 -0.0 0.1 -0.2 -0.5 0.6 -0.7 0.8
Schizophrenia (2018) 0.3 0.6 2.5 0.4 0.7 1.1 0.3 0.4 -0.9 0.7 1.6 -0.4 -0.4
Schizophrenia vs Biploar Disorder 0.6 0.8 1.7 -0.6 0.1 1.3 0.7 1.1 -0.5 1.2 1.0 1.1 0.5
Worry (Nagel 2018) 0.9 1.9 5.1 2.3 -0.7 1.0 0.2 1.4 -1.3 0.2 2.2 -1.6 1.3
Alzheimer’s Disease (in mother) 0.4 0.4 1.5 0.2 1.2 -1.0 -0.2 -0.2 0.4 0.1 -0.9 0.1 0.7
Alzheimer’s Disease (in father) 2.2 2.4 5.4 -1.3 2.1 -0.8 1.5 -1.9 2.3 -0.9 -1.0 0.2 -2.1
Alzheimer’s Disease (including proxy) 0.9 1.3 5.2 -0.9 2.3 -1.1 0.8 -1.0 1.6 0.2 -1.1 -0.0 -0.9
Crohns Disease (2017) 0.4 0.9 4.4 0.9 -0.1 -0.1 0.4 0.6 -0.0 0.5 0.9 1.3 2.1
Irritable Bowel Disease (IBD) 0.1 0.3 2.0 0.8 -0.3 -0.0 0.4 0.3 0.2 0.0 0.3 0.4 1.4
Ulcerative Colitis (UC) 0.1 0.1 0.5 0.7 -0.3 0.4 0.3 0.1 0.4 -0.2 -0.1 0.2 0.5
Major Depression (MDD) 0.8 1.0 2.2 -1.5 0.0 1.1 -0.6 0.9 -1.1 1.2 0.8 1.2 0.8
Reaction Time 0.5 1.0 6.4 2.5 -0.1 -0.3 -0.1 0.3 0.5 0.5 0.2 -1.2 1.2
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.6 -0.6 0.3 0.3 -0.7 -0.2 0.6 1.3 -1.0 1.6 -0.5
Breast Cancer 1.3 3.0 6.6 -0.9 -0.6 2.3 -2.0 2.6 -2.0 2.6 1.5 0.7 0.4
Ovarian Cancer 1.1 1.5 3.5 0.1 -1.4 1.6 -0.1 1.4 -1.3 1.9 -0.0 1.8 -0.4
Prostate Cancer 2.5 3.5 9.4 -1.2 -0.7 -2.5 0.7 -2.8 1.3 -3.1 -2.0 -1.3 -1.5
Age at First Birth 0.8 1.1 2.7 -0.9 -1.0 -0.5 1.3 0.3 -1.2 -0.5 1.5 -0.8 -1.6
Bipolar Disorder (2011) 0.6 0.5 2.1 -0.6 0.6 -1.2 1.5 -0.7 0.8 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 0.9 3.6 0.8 1.2 0.5 0.2 0.6 0.4 1.4 0.8 0.2 1.9
Coronary Artery Disease (CAD) 0.6 0.8 1.6 -0.3 -1.3 1.2 -0.6 1.0 -1.0 0.4 0.9 1.1 0.1
Crohns Disease (2012) 1.0 1.7 7.6 -1.0 1.0 1.6 -0.3 0.5 0.1 1.3 1.0 2.8 1.2
Mean Putamen Volume 0.4 0.5 1.9 1.4 0.3 0.5 0.2 0.6 -0.8 0.0 0.9 0.8 0.2
Fasting Glucose 0.4 0.5 2.8 -1.7 -0.5 -0.7 0.2 -0.1 -0.1 0.5 0.1 -0.6 -0.9
HbA1C 0.8 0.9 3.3 -1.0 -1.2 0.7 -1.8 0.6 -1.2 0.2 0.3 0.7 0.2
HDL Cholesterol 0.3 0.5 1.6 -0.4 -1.0 1.1 -0.3 0.2 -0.9 -0.1 0.0 -0.2 1.3
LDL Cholesterol 0.3 0.5 2.4 1.1 0.4 -0.4 -0.1 0.3 0.0 -0.2 1.0 -1.5 -0.1
Lupus 0.7 1.0 3.9 -1.0 -0.2 -1.1 0.4 -0.9 0.5 -0.8 -1.2 0.6 -2.0
Neuroticism (2016) 0.5 0.8 2.4 0.1 1.5 1.0 1.3 -0.1 0.2 -0.0 0.6 0.2 1.5
Primary Biliary Cirrhosis 0.2 0.2 1.2 0.4 0.3 0.5 -1.1 0.0 -0.1 -0.4 0.7 0.1 0.0
Rheumatoid Arthritis 0.3 0.4 1.2 -0.5 -0.6 0.8 -0.5 0.2 0.1 0.6 0.4 1.1 0.7
Schizophrenia (2014) 0.3 0.6 3.3 0.3 0.5 0.4 -0.1 0.2 -0.6 0.2 1.8 -1.2 -0.8
Triglycerides 0.7 1.1 3.5 -0.5 1.8 -0.9 0.9 -0.7 1.4 -0.2 -0.2 -0.3 -1.9
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.4 0.6 1.2 0.7 0.6 -0.1 0.1 1.2 0.6 1.0 -0.2
Ulcerative Colitis 0.3 0.4 1.1 1.0 0.2 -0.4 0.6 -0.5 1.0 -0.6 -0.3 -0.2 0.9
Blood Eosinophil Count 0.5 3.7 11.4 0.8 -3.4 2.8 -0.9 1.9 -2.0 2.0 1.6 0.8 1.1
Blood Platelet Count 0.7 8.1 22.2 0.5 -4.7 3.0 -3.2 3.4 -3.0 2.8 3.2 -0.5 0.9
Blood Red Count 0.4 4.0 8.8 -1.2 2.7 -1.6 1.6 -2.2 2.9 -0.5 -3.0 1.7 -0.8
Blood White Count 0.2 1.6 11.6 0.2 -3.4 0.2 -0.3 0.9 -1.5 0.5 -0.4 -0.6 -0.9
Heel T-Score 0.6 5.2 11.2 -1.5 0.3 -2.5 2.1 -2.7 2.2 -3.1 -3.4 0.5 -2.2
BMI 0.5 2.8 11.8 -0.8 0.9 1.5 2.0 0.7 -0.4 2.4 1.2 3.4 0.7
Height 0.8 14.5 30.0 1.3 4.2 -5.5 3.3 -4.6 4.5 -3.7 -4.0 -3.5 0.4
Waist Hip Ratio (WHR) 0.2 0.7 2.0 0.3 -0.0 0.8 -0.8 1.0 -1.4 0.1 0.9 -1.4 -0.4
Systolic Blood Pressure 0.3 1.4 5.7 -0.6 -0.8 -1.9 -0.3 -0.6 0.5 0.1 -0.7 -1.5 -2.4
Smoking Status 0.4 0.9 3.0 -1.7 1.4 0.1 0.6 -1.1 1.0 -0.7 -0.7 -0.8 -0.3
Allergy or Eczema 0.3 0.9 2.3 -0.6 -0.2 0.8 -1.2 1.0 -0.0 1.5 0.9 1.5 -0.1
Cardiovascular Disease 0.2 0.5 2.2 0.5 0.0 -1.0 1.5 -0.3 0.4 -0.2 0.6 -1.2 -0.2
Hypothyroidism (self reported) 1.0 2.4 5.1 -1.8 1.1 -1.3 1.6 -2.3 1.3 -1.7 -2.0 0.2 -1.1
Respiratory disease 0.5 1.1 3.1 -0.2 -1.7 1.2 -0.9 1.3 -1.8 0.8 0.5 0.4 0.4
Type 2 Diabetes (T2D) (2018) 0.4 0.7 3.2 -0.8 1.4 0.4 1.8 0.2 0.1 0.5 0.5 0.2 0.8
Lung FEV1/FVC ratio 1.2 5.8 11.6 2.0 -2.4 2.4 -0.8 3.4 -3.4 2.8 3.4 0.2 0.3
Lung FVC 0.1 0.3 1.1 -0.8 -0.5 -0.1 0.3 -0.2 0.9 -0.1 -0.0 1.1 0.4
Neuroticism 0.1 0.2 0.7 0.5 0.1 0.8 0.8 0.4 -0.3 -0.1 0.5 -0.3 -0.0
Chronotype (morning person) 0.2 0.5 1.3 0.1 -0.3 -0.4 -0.6 0.7 -0.4 0.9 0.7 -1.1 -1.1
Hair Pigment 0.1 2.2 5.7 -0.1 -1.0 1.3 -2.4 2.2 -1.7 1.5 1.1 0.5 1.6
Tanning 0.1 1.6 4.6 1.5 -0.8 1.3 -0.9 1.4 -1.1 1.1 2.1 -0.8 1.0
Hand grip strength (left) 0.3 0.7 2.9 0.6 0.2 -0.9 0.0 -0.7 1.1 -0.8 -0.4 0.5 -1.7
Number of treatments/medications taken 1.7 3.1 11.4 0.7 1.1 -2.2 3.4 -1.7 1.4 -1.0 -1.4 -1.8 -1.3
Average weekly spirits intake 0.7 0.9 2.7 0.6 -1.2 0.4 -0.2 1.3 -1.6 0.7 0.9 -0.8 0.4
Sensitivity / hurt feelings 0.4 0.7 3.0 -0.8 -0.2 1.7 -0.7 1.0 -0.6 0.5 0.5 0.7 -0.5
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.5 -0.4 1.4 -0.7 0.5 -1.3 1.2 -1.6 -0.7 -0.0 -0.1
Hearing difficulty/problems: Yes 1.0 1.6 3.9 1.3 -0.6 -1.7 0.2 -0.9 1.0 -2.0 -1.6 -1.3 0.9
Relative age of first facial hair 0.6 1.2 2.1 0.2 -1.3 -0.3 -1.4 1.1 -1.4 1.3 1.0 -1.2 -1.0
Other serious medical condition/disability diagnosed by doctor 1.8 2.4 7.3 2.7 -0.2 -2.0 1.2 -1.1 -0.1 -1.4 -0.8 -2.7 -0.3
Ever used hormone-replacement therapy (HRT) 1.8 2.3 6.0 -0.9 2.3 -0.5 0.7 -1.5 1.9 -0.1 -2.4 1.3 -1.6
Ever had hysterectomy (womb removed) 2.2 2.5 5.5 0.4 1.8 -1.9 0.6 -1.7 2.3 -1.2 -1.6 -2.3 -0.1
Systolic blood pressure, automated reading 0.3 0.8 5.5 -0.5 -0.7 -0.5 0.1 0.4 -0.4 0.9 -0.4 0.4 -2.4
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.3 0.4 1.4 -1.3 0.5 -1.2 0.7 -1.4 -0.9 -1.5 0.8
Angina 0.4 0.5 1.2 1.1 1.1 -0.3 1.1 -0.5 0.4 -0.1 -0.6 -0.6 0.2
Medication for hormone replacement therapy 0.6 0.6 1.3 -0.4 1.0 -0.7 0.2 -0.9 0.5 -1.0 -1.1 -1.1 0.1
Vitamin and mineral supplements 2.1 2.8 13.7 -0.1 -3.7 1.0 -2.4 1.4 -2.1 0.8 0.9 -0.2 -0.1
Supplements: Zinc 0.3 0.4 1.0 -0.7 1.0 0.3 0.5 -0.4 1.0 0.5 0.4 0.4 0.2
Medication: Co-codamol 0.4 0.5 1.6 -0.6 0.5 1.0 -0.2 -0.6 0.4 -0.8 -0.9 1.2 0.0
Medication: Metformin 0.4 0.6 1.5 -1.1 1.1 0.1 1.2 -0.5 0.2 -0.7 -0.0 -1.0 0.5
Diabetes (father) 0.5 0.6 2.9 -0.3 -0.2 0.2 0.7 -0.3 0.5 -0.1 -0.7 1.7 -1.2
Diabetes (mother) 0.4 0.6 1.2 -0.6 -1.1 -0.4 0.7 -0.1 -0.6 -1.0 -0.7 -1.1 -0.7
Severe depression (siblings) 0.3 0.4 1.0 1.0 -0.4 -0.5 -0.1 0.4 -0.2 -0.1 0.8 -0.7 0.9
Pack years adult smoking proportion 0.5 0.8 3.8 0.2 0.9 -0.8 1.9 -0.1 0.3 -0.3 -0.9 -0.4 1.1
Impedance of leg (right) 0.4 2.1 4.9 1.3 -2.2 0.3 -1.8 2.0 -1.9 0.6 0.2 -1.6 -0.8
Leg fat-free mass (left) 0.6 3.2 10.6 -0.2 3.3 -1.1 2.4 -2.4 2.5 -0.8 -0.9 0.8 1.0
Trunk fat percentage 0.4 1.5 4.1 0.3 0.2 1.4 2.0 0.9 -1.1 2.0 0.4 1.4 1.0
Hand grip strength (right) 0.3 0.8 5.0 0.8 0.1 -0.5 -0.4 -0.3 0.9 -0.0 -0.5 0.8 -2.2
Townsend deprivation index at recruitment 0.7 1.0 5.1 2.2 0.6 -1.5 0.6 0.1 0.8 -0.3 -1.0 -0.4 0.0
Current tobacco smoking 0.7 1.1 3.6 -0.9 1.5 -0.4 1.9 -1.0 1.5 -0.4 -0.5 -0.4 -0.7
Average weekly fortified wine intake 0.6 0.7 3.8 -0.2 0.2 0.6 1.0 0.4 -0.3 0.2 0.9 0.7 1.9
Maternal smoking around birth 1.0 1.5 5.5 2.4 -0.2 -1.2 -1.9 0.5 0.4 -0.0 -0.7 -1.7 0.8
Fed-up feelings 0.5 0.8 2.3 0.7 1.2 -0.8 0.8 -0.8 0.3 -1.5 -0.2 -1.3 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.6 0.6 -0.1 1.3 -0.9 0.1 -0.0 -0.3 0.1 -0.1 -0.0
Relative age voice broke 0.2 0.3 1.6 -0.6 -0.2 0.1 -1.3 0.2 -0.6 0.6 -0.4 -0.0 0.1
Taking other prescription medications 1.2 1.8 5.9 0.1 0.1 -1.7 2.4 -1.0 -0.2 -1.0 -0.6 -2.0 -1.6
Age when periods started (menarche) 0.4 1.0 4.0 0.8 -0.8 0.7 -0.4 0.6 -0.6 0.5 0.9 -1.4 -2.0
Bilateral oophorectomy (both ovaries removed) 4.0 4.7 9.9 -0.7 1.5 -3.1 2.1 -2.9 2.7 -2.0 -2.7 -1.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.6 0.4 0.4 0.4 1.3 -0.5 1.1 -0.2 -0.6 1.1 0.2
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 4.8 -2.2 0.1 0.2 1.6 -0.7 1.0 0.4 -1.2 1.9 1.2
Qualifications: CSEs or equivalent 1.4 1.9 7.5 2.7 -1.6 -0.3 -0.6 0.7 0.1 0.0 0.4 -2.5 1.3
Serious illness, injury or assault to yourself 0.7 0.8 2.8 -0.4 1.5 0.8 0.9 0.1 -0.3 -0.1 1.1 0.5 1.7
High blood pressure 0.3 0.7 2.9 -0.2 -0.4 -0.8 1.7 -0.7 0.7 -0.4 -1.0 -0.9 -0.2
Hayfever, allergic rhinitis or eczema 0.5 1.1 4.0 -1.0 0.0 0.7 -1.0 0.9 -0.3 1.5 1.0 2.0 -0.2
Multivitamins +/- minerals 1.1 1.3 4.4 0.5 2.1 -1.2 2.1 -0.7 1.0 -0.8 0.0 -0.7 0.3
Stomach or abdominal pain in last month 0.2 0.2 1.2 -1.1 -0.2 -0.5 0.6 -0.3 0.5 0.2 -0.4 -0.0 0.1
Supplements: Glucosamine 1.1 1.4 8.6 -1.4 0.8 0.3 2.9 -0.1 0.2 0.3 1.1 0.7 1.1
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 3.8 0.9 0.8 -0.7 1.9 -1.0 0.9 -0.3 -0.7 -1.1 0.7
Medication: Atenolol 1.0 1.3 4.9 -2.0 1.7 0.8 2.2 -0.2 -0.2 0.5 -0.5 -0.2 -0.0
Medication: Levothyroxine sodium 0.8 1.4 3.5 0.4 0.1 -1.9 1.6 -1.6 0.8 -1.3 -1.5 -0.2 -0.7
Sitting height 0.2 1.5 7.3 -0.6 2.7 -0.4 0.1 -1.2 1.9 0.1 -1.0 0.4 1.1
Chronic bronchitis/emphysema (father) 1.3 1.5 4.0 -1.7 -1.4 1.0 -2.0 0.8 -1.5 0.1 0.1 -0.3 -1.5
High blood pressure (mother) 0.6 0.9 3.2 -1.2 -0.9 -0.8 0.2 -0.7 0.1 -1.3 -0.3 -0.9 1.8
Body mass index (BMI) 0.3 1.2 4.2 -0.4 0.6 0.9 1.9 0.3 -0.1 1.5 0.7 2.1 0.4
Impedance of leg (left) 0.4 2.0 4.4 1.5 -2.1 0.0 -1.7 1.9 -1.8 0.9 -0.1 -1.4 -0.4
Leg predicted mass (left) 0.6 3.4 11.1 -0.3 3.3 -1.1 2.3 -2.5 2.6 -0.9 -1.0 0.8 0.9
Trunk fat mass 0.3 1.3 7.5 0.2 1.3 0.4 2.7 -0.2 0.1 1.1 -0.1 1.2 1.0
Waist circumference 0.1 0.5 3.6 0.2 0.6 0.1 1.9 -0.2 -0.1 0.8 0.3 0.4 0.7
Number of incorrect matches in round 1.1 1.8 2.9 -0.1 1.5 -1.6 1.7 -1.6 1.4 -1.4 -1.7 -0.6 -0.9
Past tobacco smoking 0.5 0.9 5.0 0.9 0.2 0.2 0.7 1.0 -0.3 1.0 0.9 2.2 -0.1
Alcohol usually taken with meals 0.4 0.7 3.4 -0.9 -0.6 0.4 -0.4 0.3 -0.2 0.3 1.2 1.9 0.7
Nervous feelings 0.6 1.2 4.6 1.7 0.4 -0.1 1.4 -0.0 0.2 -0.8 0.5 -2.1 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.5 0.5 1.1 0.9 -0.3 -0.3 0.2 -0.4 -0.2 -0.8 -1.2
Hearing difficulty/problems with background noise 0.6 1.0 3.6 1.9 -1.3 -1.4 0.5 0.2 -0.3 -0.9 0.2 -0.9 0.7
Hair/balding pattern: Pattern 2 1.7 2.2 6.2 0.9 -0.8 1.9 -2.5 1.7 -1.6 1.2 0.6 1.4 0.9
Had menopause 0.9 1.1 4.6 -1.2 2.1 0.5 -0.1 -1.0 0.6 -0.1 -1.4 0.8 -1.1
Had other major operations 1.2 1.5 3.4 -0.3 1.9 -0.2 0.5 -1.7 1.7 -1.0 -1.5 -1.5 0.2
Forced vital capacity (FVC) 0.4 1.5 4.8 -1.1 1.9 -0.4 0.7 -1.6 2.2 -0.7 -0.8 0.9 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.5 1.2 -0.7 0.0 0.8 0.1 0.2 -0.3 -0.3 0.4 0.9
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.0 -0.3 -1.0 -0.3 0.2 -0.0 -0.7 -0.4 0.0 -0.1 -0.6
Qualifications: None of the above 0.2 0.4 1.2 0.3 0.8 -0.4 0.6 -0.1 1.1 -0.3 -1.1 -0.5 0.5
Financial difficulties in last 2 years 1.7 2.3 8.8 -0.8 3.0 -0.2 2.0 -1.5 2.6 0.1 -0.3 0.7 0.4
Mouth/teeth dental problems 0.5 0.8 3.0 -1.1 -0.8 -0.4 -1.7 0.2 -0.4 -0.3 0.4 -0.7 -1.4
Heart attack 0.3 0.4 1.9 -1.0 0.3 0.3 1.4 0.4 -0.6 0.3 0.6 -0.1 0.6
Allergy 0.1 0.3 1.4 0.9 -0.4 0.1 0.2 -0.1 -0.1 -0.7 -0.1 -1.2 0.3
Pain all over the body in last month 0.4 0.4 1.9 -0.2 1.4 0.5 -0.1 -0.2 0.1 -0.7 0.0 -0.3 1.1
Diabetes (self-reported) 0.5 0.7 2.7 -1.6 1.4 0.7 1.2 -0.3 0.3 -0.2 0.3 0.2 0.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.8 -1.4 -0.7 -1.0 -0.3 -0.1 0.2 0.1 0.2 0.0 -1.2
Medication: Ramipril 1.2 1.5 5.3 2.1 1.7 -0.6 0.9 -0.2 0.2 -0.3 -0.1 -2.3 0.9
Medication: Simvastatin 0.7 1.1 3.3 1.4 1.5 -0.7 1.2 -0.5 1.0 -0.7 0.3 -1.8 -0.3
Fluid intelligence score 0.7 1.4 7.2 -0.8 -0.4 1.5 -0.4 0.9 -0.6 1.4 -0.1 2.7 -1.0
Illnesses of siblings 0.8 1.1 3.4 0.1 1.2 0.5 -1.8 0.1 0.9 1.8 -0.7 1.2 -0.2
Neuroticism score 0.2 0.5 1.2 0.7 0.9 1.1 0.5 0.4 -0.1 -0.0 0.8 -0.8 0.7
Weight 0.4 2.1 8.2 -0.2 2.3 -0.6 2.9 -1.4 1.6 0.3 -0.6 1.2 0.6
Impedance of arm (right) 0.7 3.1 6.8 1.0 -1.8 2.6 -2.1 2.0 -2.1 1.5 0.9 -0.4 1.9
Arm fat percentage (right) 0.5 1.8 4.4 0.3 0.0 2.0 1.2 1.2 -1.0 2.1 0.9 1.8 1.5
Trunk fat-free mass 1.1 6.3 14.6 0.1 3.8 -2.9 2.5 -3.3 3.7 -2.1 -1.6 -0.9 0.4
Hip circumference 0.3 1.1 3.3 -0.5 0.8 0.3 1.8 -0.1 0.1 1.2 0.5 1.6 1.5
Time employed in main current job 3.0 3.4 6.2 -0.0 -2.5 2.2 -1.1 2.1 -2.3 2.0 2.5 1.4 0.3
Alcohol intake versus 10 years previously 0.5 0.8 3.2 -0.0 0.2 -0.7 -1.6 -0.7 0.4 -0.8 -0.4 -1.8 0.3
Father’s age at death 0.4 0.5 2.9 -0.2 0.7 -0.2 1.7 -0.5 0.3 0.3 -0.3 1.0 -0.1
Worrier / anxious feelings 0.2 0.3 1.2 0.3 -0.8 0.8 0.0 0.0 -0.4 -0.6 0.3 -1.1 -0.0
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.1 0.5 1.2 -0.4 1.5 -0.7 0.8 -0.7 0.0 -1.4 0.9
Falls in the last year 1.3 1.7 5.0 1.3 -1.2 1.4 0.1 1.3 -0.7 1.5 0.4 2.2 1.5
Hair/balding pattern: Pattern 3 0.4 0.5 1.1 -0.4 0.4 -0.9 0.5 -1.0 0.8 -1.1 -0.8 -0.0 0.7
Number of live births 0.5 0.7 3.9 2.0 1.2 -0.6 -0.1 0.2 0.0 -0.4 -0.9 -0.4 0.1
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 3.0 -0.6 0.5 1.2 -0.0 -0.1 0.7 0.6 0.4 1.7 1.1
Pulse rate 0.5 0.9 2.1 0.5 1.2 1.5 0.8 0.8 -1.2 0.8 1.1 0.2 -0.6
Happiness 2.7 3.3 8.0 -2.1 1.6 -0.9 2.8 -2.1 2.2 -1.2 -1.2 0.7 -2.2
Noisy workplace 0.6 0.7 1.7 0.6 1.0 -1.1 0.1 -0.9 0.7 -0.7 -1.3 -0.3 -0.9
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.9 -1.4 -0.4 0.6 -0.9 0.6 -0.3 1.2 0.9 0.7 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.9 -1.7 0.6 -0.0 -0.6 -0.5 0.4 -1.0 0.3 0.8 -0.1
Mouth/teeth dental problems: Dentures 0.7 1.1 6.1 1.8 -0.4 1.0 -0.5 0.4 0.0 0.0 -0.3 0.7 2.5
Asthma 0.2 0.4 1.5 0.5 -1.2 0.5 -0.8 0.6 -0.8 0.2 0.0 0.0 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.9 1.7 -0.7 -0.2 1.1 0.1 -0.7 0.3 -0.2 -0.8 0.2
Medication: Cholesterol lowering 1.3 2.0 6.7 0.7 1.2 -1.0 2.2 -1.2 0.5 -1.3 0.6 -2.6 1.4
Depression (self-reported) 0.6 0.7 5.1 2.3 0.3 -0.4 0.3 -0.1 0.7 -0.3 0.4 0.5 0.5
Medication: Lansoprazole 0.8 0.9 5.0 -0.2 0.1 -1.0 0.7 -0.4 -0.7 -1.2 0.3 -2.2 0.4
Prospective memory result 1.1 1.4 4.9 -0.3 1.0 -1.4 1.5 -0.6 1.0 -0.5 -1.0 -1.0 -2.2
Lung cancer (father) 0.7 0.8 2.2 0.4 1.5 1.2 0.5 0.7 -0.2 0.4 0.4 1.5 1.1
Illnesses of mother 1.2 1.5 4.3 0.6 0.9 1.9 -0.4 1.1 -0.5 2.1 0.7 1.9 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.7 -0.3 0.5 1.3 -0.0 -0.1 0.8 0.7 0.4 1.3 0.6
Pulse wave Arterial Stiffness index 0.3 0.4 2.0 1.4 0.4 -0.2 -1.0 0.4 -0.1 0.5 -0.1 -0.4 -0.0
Impedance of arm (left) 0.8 3.5 7.9 0.7 -1.9 2.8 -2.0 2.4 -2.6 1.8 1.2 0.2 1.2
Arm fat mass (right) 0.3 1.2 3.1 0.2 1.3 0.8 1.8 0.0 0.4 1.4 0.1 1.8 1.2
Trunk predicted mass 1.1 6.1 14.4 0.2 3.8 -2.9 2.4 -3.3 3.7 -2.1 -1.5 -1.0 0.4
Standing height 0.7 6.7 14.7 0.6 3.8 -2.9 1.9 -3.4 3.7 -2.3 -2.4 -1.6 0.8
Length of working week for main job 0.6 0.7 1.9 -0.4 0.6 -0.3 0.9 -1.3 1.4 -1.1 -0.5 -0.3 -0.5
Exposure to tobacco smoke at home 1.3 1.4 4.4 -0.5 0.5 -1.9 2.1 -1.4 1.0 -0.7 -0.7 -0.4 -1.3
Breastfed as a baby 0.8 1.0 3.3 -1.8 -0.0 -1.2 0.9 -0.8 0.4 -0.8 0.2 -1.6 0.2
Tense / ‘highly strung’ 0.6 1.0 2.5 1.2 1.4 -0.0 1.3 0.2 0.1 -0.4 0.5 -1.4 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.2 7.8 0.7 2.8 -1.0 1.4 -1.8 1.9 -1.5 -1.1 -0.1 -0.9
Hair/balding pattern: Pattern 4 0.5 1.2 2.4 0.9 -1.2 1.5 0.7 1.4 -0.8 1.2 1.6 0.6 0.7
Birth weight of first child 2.4 4.3 8.0 -0.2 0.8 -2.8 0.2 -2.6 2.3 -2.6 -2.1 -2.6 2.1
Peak expiratory flow (PEF) 0.7 1.5 3.3 -1.0 0.4 1.8 0.0 1.3 -0.6 1.7 1.2 1.8 1.1
Pulse wave reflection index 0.4 0.5 1.4 0.5 -0.1 -0.6 -0.8 -0.4 1.2 0.5 -1.0 0.6 -0.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.8 1.9 -1.1 0.3 1.1 -0.3 0.9 0.1 -0.9 1.8 1.0
Loud music exposure frequency 0.6 0.7 1.6 -0.1 1.3 -0.3 1.2 -0.5 1.0 0.8 -0.1 0.6 -1.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.8 -0.5 0.5 -0.2 -0.1 -0.6 0.6 0.0 0.1 0.9 -0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.7 0.1 0.9 0.7 1.6 -0.0 -0.1 0.2 0.8 -0.2 1.2
Blood clot in the leg (DVT) 0.9 1.2 2.2 -1.2 1.3 -1.1 1.5 -1.5 1.3 -0.3 -1.2 -0.4 -0.4
Medication: Paracetamol 0.5 0.9 2.3 -0.4 1.2 -0.3 1.0 -1.2 1.1 -0.8 -1.5 -0.5 0.7
Headache pain in last month 0.2 0.4 1.4 -0.8 0.2 -0.2 1.2 0.3 -0.2 0.1 -0.9 0.5 0.7
Medication for cholesterol, blood pressure or diabetes 2.1 3.5 17.3 -1.4 -0.7 1.6 -2.1 1.3 -0.6 1.9 0.0 4.2 -1.5
Glaucoma (self-reported) 1.0 1.2 4.3 1.1 -1.1 -0.9 -1.4 -0.3 0.1 -0.6 -1.1 -1.1 -2.1
Gout (self-reported) 0.7 1.0 5.0 -0.0 0.0 1.3 0.5 0.7 -0.5 0.6 0.3 2.2 1.2
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.9 -0.9 0.1 -0.8 1.3 -1.7 0.6 -1.7 -1.7 0.6 -0.6
Medication: Amlodipine 0.4 0.6 2.1 0.9 -1.1 -0.5 0.5 0.1 -0.7 -0.0 -0.2 -1.5 -0.9
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.3 -0.0 0.3 -1.5 -0.3 -0.4 0.9 0.1 -1.5 1.2 -0.3
Birth weight 0.6 1.2 3.3 0.2 1.8 -1.1 1.7 -1.1 1.2 -0.5 -1.3 -0.2 0.4
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.7 -0.8 -0.1 0.5 -0.2 -0.4 0.4 -0.1 -0.7 0.4 -0.9
High blood pressure (siblings) 0.7 1.0 3.7 -0.3 -0.7 -0.5 1.5 -0.4 -0.3 -1.9 0.7 -1.1 1.2
Forced vital capacity (FVC), Best measure 0.4 1.3 4.6 -1.1 1.8 0.2 0.5 -1.4 2.2 -0.3 -0.6 1.1 0.3
Body fat percentage 0.4 1.4 3.7 0.2 0.1 1.4 1.9 0.9 -0.9 1.9 0.4 1.6 1.0
Leg fat percentage (right) 0.3 1.1 3.1 0.2 -0.3 1.0 1.8 0.9 -0.8 1.5 0.6 1.5 -0.6
Arm fat-free mass (right) 1.3 6.4 16.4 -0.5 4.0 -2.9 2.8 -3.4 3.5 -2.0 -1.9 -0.2 -0.3
Exposure to tobacco smoke outside home 0.7 1.0 2.8 -0.1 1.4 -0.9 1.7 -1.0 0.7 -1.2 -0.0 -0.9 0.8
Comparative body size at age 10 0.4 1.0 3.4 0.6 1.0 0.2 1.8 0.3 -0.6 0.5 1.4 -0.2 1.8
Number of full brothers 1.2 1.5 6.9 -1.3 -2.6 0.0 -0.4 -0.5 -0.9 -1.2 0.4 -1.6 -0.7
Worry too long after embarrassment 0.7 1.1 3.1 0.2 0.9 -0.1 1.8 -1.3 0.8 -1.6 -0.5 -1.5 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 6.2 2.4 1.3 -1.7 0.6 -1.5 0.8 -2.2 -0.9 -2.5 -0.5
Wheeze or whistling in the chest in last year 0.5 0.9 2.3 -0.6 -0.1 -1.4 1.3 -0.9 1.0 -0.4 -1.5 0.5 -0.8
Number of children fathered 0.5 0.5 1.8 -0.7 -0.5 -0.3 0.2 -0.6 0.1 -1.1 -1.3 0.9 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.5 1.0 -0.3 1.5 -1.0 1.1 -0.4 2.1 0.9 0.3 1.0
Age at first live birth 0.7 1.2 3.6 0.0 -0.7 1.7 -1.0 0.6 -0.4 0.6 1.7 1.9 0.0
Pulse wave peak to peak time 0.4 0.5 2.3 -1.5 -0.2 -0.1 1.1 -0.7 0.4 -0.7 -0.2 0.2 0.1
Health satisfaction 1.9 2.4 11.2 -1.3 2.1 -1.8 3.4 -1.2 0.8 -0.9 -0.7 -0.2 -0.8
Shortness of breath walking on level ground 0.3 0.4 3.1 -0.1 0.2 0.0 0.2 0.0 0.3 0.8 -0.2 0.3 -1.8
Qualifications: College or University degree 0.2 0.6 3.3 -1.1 0.2 0.1 -0.1 0.2 -0.2 0.6 1.0 1.8 -0.4
Eye problems/disorders: None of the above 0.4 0.5 1.5 0.4 0.9 -0.8 1.2 -0.2 0.0 -0.7 0.4 0.0 1.1
Mouth/teeth dental problems: Loose teeth 0.6 0.8 2.3 1.1 0.8 -0.2 1.5 0.5 -0.7 0.5 1.1 0.5 -1.1
Emphysema/chronic bronchitis 0.4 0.5 3.1 -1.8 -0.1 -0.0 0.1 -0.6 0.2 -0.4 -0.7 0.3 -0.7
Medication for pain relief, constipation, heartburn 0.5 0.8 4.6 -0.1 -0.4 0.9 -2.1 0.7 -0.1 0.3 1.1 0.8 0.5
Neck or shoulder pain in last month 0.7 1.0 3.9 0.8 0.6 -1.1 2.0 -0.5 0.6 -0.7 -0.0 -1.5 0.5
Medication: Blood pressure 1.6 2.8 16.2 1.9 0.1 -0.6 1.6 -0.3 -0.2 -0.8 0.8 -4.0 1.8
Angina (self-reported) 0.4 0.5 1.6 1.1 1.2 -0.2 1.3 -0.5 0.4 -0.1 -0.7 -0.2 0.4
Migraine (self-reported) 1.3 1.6 3.3 -0.7 1.3 -1.1 1.7 -1.3 1.8 -0.5 -1.3 -1.0 -1.5
Medication: Ibuprofen 0.3 0.3 1.3 0.6 0.2 -0.6 1.2 -0.4 -0.2 -0.1 -0.6 -0.7 0.1
Medication: Allopurinol 0.5 0.7 1.9 -1.3 1.4 0.5 1.1 -0.4 -0.2 -0.3 -0.2 1.3 0.4
Medication: Omeprazole 1.4 1.7 4.5 -1.5 1.5 0.5 1.6 -0.9 1.2 -0.0 -1.7 2.1 -0.3
Medication: Seretide 50 evohaler 0.5 0.6 1.4 -0.8 -0.3 -0.7 -0.1 -1.0 0.6 -0.8 -1.2 -0.6 -0.8
Mean time to correctly identify matches 1.5 2.9 5.4 2.3 1.1 -2.2 1.1 -1.7 2.2 -1.1 -1.7 -2.0 0.4
Heart disease (mother) 1.2 1.4 4.3 -1.3 -1.8 0.0 -1.5 0.2 -1.2 -0.4 1.1 -2.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.7 -1.1 0.7 1.0 0.7 0.6 -0.2 0.8 1.3 0.9 0.6
Whole body fat mass 0.3 1.2 6.4 0.4 1.4 0.3 2.5 -0.2 0.4 1.0 -0.3 1.2 1.0
Leg fat mass (right) 0.2 0.9 5.3 0.0 1.1 0.2 2.3 -0.4 0.5 0.6 -0.3 1.2 0.3
Arm predicted mass (right) 1.2 6.2 16.7 -1.0 4.1 -2.7 2.7 -3.3 3.4 -1.9 -1.8 0.1 -0.5
Pulse rate, automated reading 0.4 1.1 3.0 -0.3 0.7 1.7 -0.1 1.1 -1.4 1.4 1.2 1.0 -0.7
Alcohol intake frequency. 0.9 2.1 4.0 0.6 1.1 -2.0 1.6 -1.5 1.6 -1.5 -1.6 -1.7 -0.7
Comparative height size at age 10 0.6 3.2 9.8 0.0 3.1 -1.5 1.9 -2.2 2.7 -1.1 -1.6 -0.4 -0.9
Number of full sisters 1.7 2.0 8.0 0.9 0.0 -1.6 -0.1 -1.2 0.3 -2.8 -1.4 -2.4 0.4
Suffer from ‘nerves’ 0.8 1.3 6.2 2.5 0.6 0.2 0.0 0.7 -0.4 -0.2 0.7 -0.8 2.2
Overall health rating 1.2 2.6 10.7 0.5 2.7 -1.2 3.3 -1.1 1.1 -0.8 -1.1 -1.1 0.8
Chest pain or discomfort 0.7 1.0 8.9 -0.1 0.4 -0.1 3.0 -0.2 0.5 0.8 0.3 0.2 0.3
Had major operations 0.5 0.6 1.8 0.2 0.5 -0.1 1.1 0.3 -0.6 -1.0 1.0 -0.4 1.4
Age at last live birth 0.4 0.6 1.8 1.3 0.2 0.8 -0.5 0.4 -0.0 0.2 1.3 1.0 -0.2
Family relationship satisfaction 2.2 2.7 7.5 -0.4 2.1 -0.5 2.7 -1.7 2.0 -0.8 -1.5 2.2 0.4
Leg pain on walking 0.9 1.1 4.4 -0.8 0.4 -1.2 2.1 -0.5 0.3 -1.0 -0.6 1.0 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 5.0 0.8 -0.5 -0.6 0.1 -0.4 -0.3 -0.8 -0.7 -2.2 -0.3
Commuting to job workplace: Car/motor vehicle 1.4 1.6 4.3 0.2 -0.9 1.7 -1.3 1.4 -1.2 2.1 0.9 1.0 1.0
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 6.4 0.7 -1.9 -1.2 -1.6 -0.5 0.0 -0.6 -1.8 -0.6 -2.5
Medication: Aspirin 1.4 1.9 7.4 0.8 -0.1 -1.9 1.5 -1.1 0.7 -1.4 -0.6 -2.7 -0.5
Supplements: Vitamin C 3.8 4.5 10.8 -1.2 3.1 -1.6 1.9 -2.6 3.3 -1.6 -2.6 -0.1 0.9
Knee pain experienced in last month 1.5 2.3 13.6 -1.1 1.4 -0.3 3.7 -1.3 0.5 -1.4 0.4 -0.7 1.3
Hypertension (Self-reported) 0.4 1.0 3.9 -0.3 -0.3 -0.9 2.0 -1.0 0.8 -0.9 -1.0 -1.3 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.8 7.6 -1.1 2.8 -1.9 2.2 -1.7 1.2 -1.3 -1.8 0.9 -1.3
Illnesses of father: Heart disease 0.2 0.2 0.6 -0.1 0.7 -0.5 -0.3 -0.5 0.1 -0.6 -0.1 -0.5 -0.8
Illnesses of siblings: Diabetes 0.2 0.2 0.4 0.3 -0.7 -0.2 0.6 0.5 -0.6 -0.5 -0.1 -0.4 0.6
Smoking status: Previous 0.5 0.8 3.8 -0.5 -0.3 0.0 -1.3 -0.7 0.1 -1.0 -0.7 -1.9 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.0 -1.0 0.8 0.6 -0.0 -0.3 0.9 -0.0 0.9 0.4 0.0
Whole body fat-free mass 0.9 5.2 14.4 -0.1 3.8 -2.4 2.6 -3.1 3.4 -1.6 -1.4 -0.3 0.6
Leg fat-free mass (right) 0.7 3.8 12.3 -0.3 3.5 -1.2 2.4 -2.5 2.7 -0.8 -1.0 0.9 1.2
Arm fat percentage (left) 0.6 2.2 5.5 -0.0 0.3 2.2 1.4 1.2 -1.1 2.3 0.9 2.4 1.1
Average weekly red wine intake 1.0 1.4 5.3 -1.0 0.9 2.1 0.5 0.3 -0.5 1.4 0.5 2.3 0.2
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.5 -0.6 -0.2 0.7 0.4 -0.4 0.5 -0.2 -0.5 0.1 -0.1
Mood swings 0.2 0.3 1.5 0.6 0.8 0.0 -0.4 -0.3 0.5 -0.2 0.2 -1.2 0.5
Loneliness, isolation 0.4 0.6 1.9 0.8 1.0 0.2 0.5 -0.8 1.4 -0.5 -1.1 -0.2 0.2
Long-standing illness, disability or infirmity 0.8 1.2 4.8 0.3 1.5 -1.0 1.9 -0.5 0.0 -0.2 -0.2 -2.2 0.1
Ever had bowel cancer screening 0.9 1.0 5.6 1.7 0.6 -0.9 2.4 -0.0 -0.1 0.4 -0.3 -0.1 0.4
Diabetes diagnosed by doctor 0.5 0.8 2.4 -1.5 1.6 0.0 1.3 -0.7 0.6 -0.6 0.2 -0.5 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 5.0 0.8 -0.7 -0.8 1.3 0.3 -0.4 -0.0 0.0 -1.1 -2.2
Friendships satisfaction 0.2 0.3 1.3 -0.5 0.4 0.3 0.2 -0.3 0.2 -0.3 -0.6 1.1 -0.5
Qualifications: nursing, teaching 1.3 2.0 7.4 0.5 -2.0 0.6 -0.4 1.3 -1.7 1.5 0.7 2.7 0.5
Commuting to job workplace: Walk 0.7 0.7 4.5 -2.1 -0.2 1.1 -0.8 -0.4 -0.1 -0.2 0.4 0.4 0.2
Eye problems/disorders: Cataract 0.5 0.5 1.5 -1.2 -0.1 0.2 -0.7 -0.5 0.7 0.3 -0.7 0.9 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.2 0.4 0.7 -1.4 1.3 -0.7 0.6 -0.2 -1.5 0.3 0.2
Medication for cholesterol 0.9 1.3 4.9 1.4 -0.7 0.9 -0.4 0.8 -1.1 0.3 1.5 0.4 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.8 1.1 -1.3 0.8 0.3 1.7 -1.0 1.6 1.3 -1.4 0.8
Back pain experienced in last month 1.3 1.9 3.5 0.8 1.8 -1.3 1.9 -1.5 1.8 -1.3 -1.0 -0.8 0.7
Mineral and other dietary supplements 1.2 1.6 6.5 -0.0 -1.8 1.2 -2.5 0.8 -1.1 0.3 0.2 0.4 -1.8
Breast cancer (self-reported) 1.8 2.2 5.4 -0.3 -0.4 1.9 -2.3 1.6 -1.4 1.6 2.2 -0.4 -0.8
Asthma (self-reported) 0.1 0.2 1.0 0.3 -1.0 0.2 -0.4 0.4 -0.6 0.1 -0.1 -0.1 -0.2
Osteoporosis (self-reported) 0.7 0.9 2.3 1.2 -0.5 -0.5 1.2 -0.6 0.2 -1.5 0.1 -1.0 1.4
Osteoarthritis (self-reported) 0.8 1.0 4.1 -0.7 1.7 0.9 2.0 -0.1 0.4 0.2 -0.3 0.5 1.2
Medication: Aspirin 1.2 1.5 5.7 0.8 -0.1 -1.5 1.8 -1.0 0.9 -0.8 -0.6 -2.4 -0.4
Medication: Gliclazide 0.7 0.8 3.5 -1.9 0.8 1.2 0.7 -0.4 0.7 0.3 -0.1 0.8 -0.8
Illnesses of father: None of the above (group 1) 1.6 2.0 5.1 1.8 -0.2 0.9 0.6 1.2 0.3 2.3 1.1 1.7 2.1
Smoking status: Current 1.0 1.5 3.8 -1.7 1.7 -0.2 1.9 -1.3 1.6 -0.4 -1.0 -0.0 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.7 2.3 0.6 1.1 -0.9 -0.7 -0.3 1.3 -0.1 -0.1 -0.3 1.5
Whole body water mass 0.9 5.2 13.8 -0.0 3.7 -2.4 2.6 -3.1 3.4 -1.6 -1.4 -0.3 0.5
Leg predicted mass (right) 0.7 3.7 12.0 -0.3 3.5 -1.2 2.4 -2.5 2.6 -0.8 -1.1 1.0 1.2
Arm fat mass (left) 0.3 1.3 3.7 -0.0 1.5 0.9 1.9 0.0 0.3 1.3 -0.0 1.8 1.0
Number of self-reported non-cancer illnesses 1.5 2.7 8.0 0.8 1.0 -2.3 2.8 -1.6 1.3 -1.4 -1.2 -1.5 -1.3
Average weekly champagne plus white wine intake 2.5 3.5 8.9 -1.7 0.1 3.0 -1.0 1.6 -1.3 2.4 1.9 2.4 1.7
Miserableness 0.5 0.9 3.7 -1.0 1.9 0.3 1.5 -0.1 0.1 -0.3 0.5 -0.2 1.0
Guilty feelings 0.3 0.5 2.6 0.5 1.6 1.1 0.3 -0.4 0.6 -0.1 -0.2 0.2 0.7
Wears glasses or contact lenses 1.2 1.4 2.5 0.1 1.3 -1.5 1.3 -1.5 0.3 -1.6 -1.4 -1.0 -0.9
Ever taken oral contraceptive pill 2.8 3.1 7.3 -0.8 0.7 -2.7 1.9 -2.3 1.8 -2.3 -0.9 -1.9 -0.9
Hearing aid user 1.2 1.3 3.0 0.6 -0.0 -1.7 1.5 -1.0 0.3 -1.7 -0.8 -1.3 -1.2
Mother’s age at death 2.9 3.6 8.0 -1.5 1.0 -1.7 1.6 -2.4 2.3 -1.7 -2.8 1.2 -1.9
Financial situation satisfaction 1.7 2.2 9.3 -1.3 0.6 1.0 3.0 0.5 0.0 1.4 0.4 2.6 -0.0
Tinnitus: Yes, now most or all of the time 1.9 2.2 5.6 0.2 1.3 -1.0 -0.8 -1.6 2.4 -2.0 -2.0 -1.4 0.0
Commuting to job workplace: Public transport 1.6 2.0 4.0 0.2 1.1 -2.0 1.2 -1.8 1.7 -1.6 -1.4 -1.0 -1.3
Eye problems/disorders: Glaucoma 0.6 0.7 5.6 0.8 -0.6 -0.2 -0.3 0.5 -0.3 0.5 -0.6 -0.1 -2.4
Medication: Blood pressure 0.6 1.1 4.9 -1.9 0.5 0.7 0.6 -0.2 0.3 0.4 -0.0 0.8 -2.2
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.3 0.4 0.2 0.5 1.1 0.1 -0.5 0.0 0.3 0.3 0.9
Supplements: Fish oil (including cod liver oil) 0.9 1.1 3.8 0.2 1.6 -0.9 1.9 -0.7 1.2 -0.2 -1.1 -0.4 1.0
High cholesterol (Self-reported) 0.4 0.7 2.2 1.5 0.6 -0.5 0.6 -0.2 -0.1 -1.0 1.0 -1.4 -0.5
Medication: Bendroflumethiazide 0.7 1.1 2.8 -0.7 -1.1 1.3 1.2 0.9 -0.3 1.7 0.5 1.4 -0.7
Medication: Paracetamol 0.4 0.5 1.4 -0.0 1.2 0.2 1.1 -0.8 1.0 -0.1 -0.8 -0.3 0.7
Medication: Lisinopril 0.3 0.4 1.0 0.7 1.0 0.3 0.4 -0.1 0.9 -0.9 -0.2 0.1 1.0
Medication: Atorvastatin 0.6 0.7 4.2 0.7 0.1 -1.0 0.8 -0.6 -0.4 -0.5 -0.4 -2.0 0.1
Illnesses of father: High blood pressure 0.5 0.6 2.6 -0.6 -0.4 0.1 1.0 -0.1 -0.9 -0.9 0.4 -0.8 1.6
Alcohol drinker status: Never 2.1 2.6 7.2 1.3 0.9 -2.7 0.8 -1.3 1.9 -1.3 -2.6 -0.3 -1.3
Ever smoked 0.4 0.7 4.6 -0.7 -1.1 0.1 -0.5 -0.1 -0.4 -0.6 0.2 -2.1 0.2
Basal metabolic rate 0.8 4.7 12.8 -0.1 3.6 -2.0 2.7 -2.8 3.2 -1.2 -1.4 0.2 0.7
Leg fat percentage (left) 0.3 1.1 3.9 0.2 -0.3 0.8 2.0 0.8 -0.7 1.6 0.3 1.7 -0.3
Arm fat-free mass (left) 1.0 5.1 13.5 -0.2 3.7 -2.5 2.7 -2.9 3.3 -1.5 -1.5 -0.2 0.4
Number of operations (self-reported) 2.0 2.9 6.1 -0.2 2.1 -1.5 2.5 -2.0 1.8 -1.9 -1.9 -1.2 0.9
Average weekly beer plus cider intake 1.7 2.4 11.2 1.2 -3.3 0.3 -0.8 0.9 -0.7 0.1 1.1 -2.5 -1.3
Irritability 0.3 0.5 1.0 -0.6 1.0 0.7 0.6 -0.6 0.9 -0.1 -1.0 0.7 0.2
Risk taking 0.1 0.2 0.5 -0.1 -0.3 -0.2 -0.5 0.3 -0.7 -0.6 0.3 -0.7 -0.1
Ever had prostate specific antigen (PSA) test 2.1 2.4 6.1 1.5 0.6 -2.4 2.5 -1.4 0.9 -1.2 -1.0 -2.0 0.7
Fractured/broken bones in last 5 years 0.6 0.7 3.6 -0.3 0.2 -0.2 1.9 -0.2 -0.6 -0.6 1.6 0.2 0.3
Age started oral contraceptive pill 2.2 2.8 7.6 -2.6 -0.6 -1.6 0.5 -2.0 1.0 -1.4 -1.9 0.2 -2.8
Diastolic blood pressure, automated reading 0.4 1.3 5.0 -1.1 0.1 0.0 0.4 -0.2 0.2 1.3 -0.5 2.2 -2.2
Ever depressed for a whole week 1.3 1.5 3.7 -1.9 0.5 -0.5 1.6 -1.3 0.1 -1.1 -1.0 1.5 -1.6
Unable to work because of sickness or disability 0.9 1.2 3.2 0.7 1.6 -1.1 1.8 -1.0 0.3 -0.8 -0.6 -0.7 -1.5
Commuting to job workplace: Cycle 0.4 0.5 2.5 -0.5 0.7 0.2 0.5 0.3 -0.1 0.3 -0.7 0.7 -1.6
Myopia 0.7 1.0 4.8 0.0 0.7 -1.9 2.2 -0.6 0.4 0.2 -0.5 0.0 -0.1
Vascular/heart problems diagnosed by doctor 0.4 1.1 4.2 -0.2 0.6 1.3 -2.0 0.7 -0.6 0.4 0.8 1.5 0.8
Cholesterol lowering medication 0.7 1.0 2.8 1.1 1.0 -1.5 0.8 -0.2 0.6 -0.2 -0.6 -1.7 -1.3
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 4.9 -2.2 2.2 0.4 2.0 -1.3 1.3 -0.0 -1.5 2.1 -0.7
Pain experienced in last month 0.7 1.2 6.3 0.4 -0.6 0.5 -2.5 -0.0 0.2 0.9 0.2 1.1 -1.6
Supplements: Calcium 1.1 1.2 5.8 -0.8 0.6 0.6 -0.0 -0.8 1.6 -0.6 -0.8 1.0 2.4
Basal cell carcinoma (self-reported) 0.7 0.9 2.9 0.2 0.6 0.6 1.2 0.1 0.0 -0.2 -0.9 1.7 1.7
Heart attack/myocardial infarction (self-reported) 0.3 0.4 2.0 -0.7 0.6 0.2 1.4 0.3 -0.3 0.4 0.5 -0.1 0.4
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.0 -1.1 1.2 -0.9 1.4 -1.2 1.0 -0.3 -0.7 -0.5 -0.2
Heart disease (siblings) 0.2 0.2 1.2 -0.8 0.1 0.3 1.1 -0.2 -0.1 -0.1 0.1 -0.5 -0.4
Alcohol drinker status: Previous 1.9 2.2 4.1 -0.9 1.4 -0.7 1.8 -2.0 1.3 -1.4 -1.2 -1.4 -2.0
Pack years of smoking 0.7 1.0 3.6 -0.3 1.1 -0.9 1.9 -0.4 0.7 -0.5 -1.5 -0.0 0.9
Impedance of whole body 0.5 2.4 5.5 0.9 -2.1 1.6 -1.6 2.2 -2.3 1.5 0.5 -0.4 0.5
Leg fat mass (left) 0.3 1.1 5.8 -0.0 1.2 0.3 2.4 -0.3 0.5 0.9 -0.3 1.4 0.4
Arm predicted mass (left) 1.0 5.3 13.3 0.0 3.6 -2.7 2.6 -3.0 3.3 -1.6 -1.7 -0.2 0.1