Hub : Genes

ZNF543

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0260	0.00910	0.027	0.017	0.041	0.028	0.034	2.7e-04	3.6e-03	8.4e-06	2.1e-04	4.3e-05
2	GTEx	Artery Tibial	0.0834	0.0313	0.00160	0.000	NA	0.009	NA	0.006	3.4e-01	NA	6.0e-02	NA	9.5e-02
3	GTEx	Cells EBV-transformed lymphocytes	0.3840	0.1190	0.00081	0.073	NA	0.238	NA	0.142	2.3e-03	NA	2.6e-08	NA	2.3e-05
4	GTEx	Colon Transverse	0.1670	0.0650	0.00930	-0.006	NA	-0.006	NA	-0.006	8.2e-01	NA	7.9e-01	NA	8.9e-01
5	METSIM	Adipose	0.0428	0.0191	0.01100	0.044	0.002	0.049	0.024	0.046	3.2e-07	1.5e-01	7.0e-08	1.2e-04	1.7e-07
6	YFS	Blood	0.1263	0.0210	0.00000	0.140	0.116	0.142	0.139	0.145	2.0e-43	6.1e-36	4.2e-44	3.1e-43	4.9e-45
7	TCGA	Breast Invasive Carcinoma	0.0286	0.0126	0.00047	0.022	0.019	0.020	NA	0.024	2.3e-05	5.7e-05	5.4e-05	NA	7.4e-06
8	TCGA	Brain Lower Grade Glioma	0.0582	0.0300	0.00440	0.009	0.012	0.008	NA	0.016	3.0e-02	1.4e-02	3.7e-02	NA	4.9e-03
9	TCGA	Lung Adenocarcinoma	0.0658	0.0275	0.00013	0.031	0.036	0.035	NA	0.045	1.3e-04	4.6e-05	5.3e-05	NA	5.2e-06
10	TCGA	Lung Squamous Cell Carcinoma	0.0913	0.0473	0.00340	0.027	0.009	0.014	NA	0.011	3.8e-04	2.7e-02	8.5e-03	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.1	0.2	0.5	0.1	-0.5	-0.0	0.3	0.0	-0.3	-0.2	0.7	-0.5	-0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	4.2	0.4	0.2	0.9	0.3	0.4	-0.9	0.4	2.0	-0.7	-0.6
Depressed Affect (Nagel 2018)	0.0	0.1	0.4	0.2	0.6	0.1	-0.2	-0.1	0.2	-0.2	0.2	-0.2	0.7
Depression (Nagel 2018)	0.1	0.2	0.5	-0.1	-0.3	0.2	-0.6	-0.7	0.7	-0.5	-0.4	0.4	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	2.8	-0.0	0.4	0.2	-0.5	0.3	0.5	1.7	-0.1	0.7	0.1
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.6	0.1	0.9	-0.0	0.1	-0.2	-0.5	0.6	-0.7	0.8
Schizophrenia (2018)	0.3	0.6	2.5	0.4	0.7	1.1	0.3	0.4	-0.9	0.7	1.6	-0.4	-0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.7	-0.6	0.1	1.3	0.7	1.1	-0.5	1.2	1.0	1.1	0.5
Worry (Nagel 2018)	0.9	1.9	5.1	2.3	-0.7	1.0	0.2	1.4	-1.3	0.2	2.2	-1.6	1.3
Alzheimer’s Disease (in mother)	0.4	0.4	1.5	0.2	1.2	-1.0	-0.2	-0.2	0.4	0.1	-0.9	0.1	0.7
Alzheimer’s Disease (in father)	2.2	2.4	5.4	-1.3	2.1	-0.8	1.5	-1.9	2.3	-0.9	-1.0	0.2	-2.1
Alzheimer’s Disease (including proxy)	0.9	1.3	5.2	-0.9	2.3	-1.1	0.8	-1.0	1.6	0.2	-1.1	-0.0	-0.9
Crohns Disease (2017)	0.4	0.9	4.4	0.9	-0.1	-0.1	0.4	0.6	-0.0	0.5	0.9	1.3	2.1
Irritable Bowel Disease (IBD)	0.1	0.3	2.0	0.8	-0.3	-0.0	0.4	0.3	0.2	0.0	0.3	0.4	1.4
Ulcerative Colitis (UC)	0.1	0.1	0.5	0.7	-0.3	0.4	0.3	0.1	0.4	-0.2	-0.1	0.2	0.5
Major Depression (MDD)	0.8	1.0	2.2	-1.5	0.0	1.1	-0.6	0.9	-1.1	1.2	0.8	1.2	0.8
Reaction Time	0.5	1.0	6.4	2.5	-0.1	-0.3	-0.1	0.3	0.5	0.5	0.2	-1.2	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.6	-0.6	0.3	0.3	-0.7	-0.2	0.6	1.3	-1.0	1.6	-0.5
Breast Cancer	1.3	3.0	6.6	-0.9	-0.6	2.3	-2.0	2.6	-2.0	2.6	1.5	0.7	0.4
Ovarian Cancer	1.1	1.5	3.5	0.1	-1.4	1.6	-0.1	1.4	-1.3	1.9	-0.0	1.8	-0.4
Prostate Cancer	2.5	3.5	9.4	-1.2	-0.7	-2.5	0.7	-2.8	1.3	-3.1	-2.0	-1.3	-1.5
Age at First Birth	0.8	1.1	2.7	-0.9	-1.0	-0.5	1.3	0.3	-1.2	-0.5	1.5	-0.8	-1.6
Bipolar Disorder (2011)	0.6	0.5	2.1	-0.6	0.6	-1.2	1.5	-0.7	0.8	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	3.6	0.8	1.2	0.5	0.2	0.6	0.4	1.4	0.8	0.2	1.9
Coronary Artery Disease (CAD)	0.6	0.8	1.6	-0.3	-1.3	1.2	-0.6	1.0	-1.0	0.4	0.9	1.1	0.1
Crohns Disease (2012)	1.0	1.7	7.6	-1.0	1.0	1.6	-0.3	0.5	0.1	1.3	1.0	2.8	1.2
Mean Putamen Volume	0.4	0.5	1.9	1.4	0.3	0.5	0.2	0.6	-0.8	0.0	0.9	0.8	0.2
Fasting Glucose	0.4	0.5	2.8	-1.7	-0.5	-0.7	0.2	-0.1	-0.1	0.5	0.1	-0.6	-0.9
HbA1C	0.8	0.9	3.3	-1.0	-1.2	0.7	-1.8	0.6	-1.2	0.2	0.3	0.7	0.2
HDL Cholesterol	0.3	0.5	1.6	-0.4	-1.0	1.1	-0.3	0.2	-0.9	-0.1	0.0	-0.2	1.3
LDL Cholesterol	0.3	0.5	2.4	1.1	0.4	-0.4	-0.1	0.3	0.0	-0.2	1.0	-1.5	-0.1
Lupus	0.7	1.0	3.9	-1.0	-0.2	-1.1	0.4	-0.9	0.5	-0.8	-1.2	0.6	-2.0
Neuroticism (2016)	0.5	0.8	2.4	0.1	1.5	1.0	1.3	-0.1	0.2	-0.0	0.6	0.2	1.5
Primary Biliary Cirrhosis	0.2	0.2	1.2	0.4	0.3	0.5	-1.1	0.0	-0.1	-0.4	0.7	0.1	0.0
Rheumatoid Arthritis	0.3	0.4	1.2	-0.5	-0.6	0.8	-0.5	0.2	0.1	0.6	0.4	1.1	0.7
Schizophrenia (2014)	0.3	0.6	3.3	0.3	0.5	0.4	-0.1	0.2	-0.6	0.2	1.8	-1.2	-0.8
Triglycerides	0.7	1.1	3.5	-0.5	1.8	-0.9	0.9	-0.7	1.4	-0.2	-0.2	-0.3	-1.9
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.4	0.6	1.2	0.7	0.6	-0.1	0.1	1.2	0.6	1.0	-0.2
Ulcerative Colitis	0.3	0.4	1.1	1.0	0.2	-0.4	0.6	-0.5	1.0	-0.6	-0.3	-0.2	0.9
Blood Eosinophil Count	0.5	3.7	11.4	0.8	-3.4	2.8	-0.9	1.9	-2.0	2.0	1.6	0.8	1.1
Blood Platelet Count	0.7	8.1	22.2	0.5	-4.7	3.0	-3.2	3.4	-3.0	2.8	3.2	-0.5	0.9
Blood Red Count	0.4	4.0	8.8	-1.2	2.7	-1.6	1.6	-2.2	2.9	-0.5	-3.0	1.7	-0.8
Blood White Count	0.2	1.6	11.6	0.2	-3.4	0.2	-0.3	0.9	-1.5	0.5	-0.4	-0.6	-0.9
Heel T-Score	0.6	5.2	11.2	-1.5	0.3	-2.5	2.1	-2.7	2.2	-3.1	-3.4	0.5	-2.2
BMI	0.5	2.8	11.8	-0.8	0.9	1.5	2.0	0.7	-0.4	2.4	1.2	3.4	0.7
Height	0.8	14.5	30.0	1.3	4.2	-5.5	3.3	-4.6	4.5	-3.7	-4.0	-3.5	0.4
Waist Hip Ratio (WHR)	0.2	0.7	2.0	0.3	-0.0	0.8	-0.8	1.0	-1.4	0.1	0.9	-1.4	-0.4
Systolic Blood Pressure	0.3	1.4	5.7	-0.6	-0.8	-1.9	-0.3	-0.6	0.5	0.1	-0.7	-1.5	-2.4
Smoking Status	0.4	0.9	3.0	-1.7	1.4	0.1	0.6	-1.1	1.0	-0.7	-0.7	-0.8	-0.3
Allergy or Eczema	0.3	0.9	2.3	-0.6	-0.2	0.8	-1.2	1.0	-0.0	1.5	0.9	1.5	-0.1
Cardiovascular Disease	0.2	0.5	2.2	0.5	0.0	-1.0	1.5	-0.3	0.4	-0.2	0.6	-1.2	-0.2
Hypothyroidism (self reported)	1.0	2.4	5.1	-1.8	1.1	-1.3	1.6	-2.3	1.3	-1.7	-2.0	0.2	-1.1
Respiratory disease	0.5	1.1	3.1	-0.2	-1.7	1.2	-0.9	1.3	-1.8	0.8	0.5	0.4	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.2	-0.8	1.4	0.4	1.8	0.2	0.1	0.5	0.5	0.2	0.8
Lung FEV1/FVC ratio	1.2	5.8	11.6	2.0	-2.4	2.4	-0.8	3.4	-3.4	2.8	3.4	0.2	0.3
Lung FVC	0.1	0.3	1.1	-0.8	-0.5	-0.1	0.3	-0.2	0.9	-0.1	-0.0	1.1	0.4
Neuroticism	0.1	0.2	0.7	0.5	0.1	0.8	0.8	0.4	-0.3	-0.1	0.5	-0.3	-0.0
Chronotype (morning person)	0.2	0.5	1.3	0.1	-0.3	-0.4	-0.6	0.7	-0.4	0.9	0.7	-1.1	-1.1
Hair Pigment	0.1	2.2	5.7	-0.1	-1.0	1.3	-2.4	2.2	-1.7	1.5	1.1	0.5	1.6
Tanning	0.1	1.6	4.6	1.5	-0.8	1.3	-0.9	1.4	-1.1	1.1	2.1	-0.8	1.0
Hand grip strength (left)	0.3	0.7	2.9	0.6	0.2	-0.9	0.0	-0.7	1.1	-0.8	-0.4	0.5	-1.7
Number of treatments/medications taken	1.7	3.1	11.4	0.7	1.1	-2.2	3.4	-1.7	1.4	-1.0	-1.4	-1.8	-1.3
Average weekly spirits intake	0.7	0.9	2.7	0.6	-1.2	0.4	-0.2	1.3	-1.6	0.7	0.9	-0.8	0.4
Sensitivity / hurt feelings	0.4	0.7	3.0	-0.8	-0.2	1.7	-0.7	1.0	-0.6	0.5	0.5	0.7	-0.5
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.5	-0.4	1.4	-0.7	0.5	-1.3	1.2	-1.6	-0.7	-0.0	-0.1
Hearing difficulty/problems: Yes	1.0	1.6	3.9	1.3	-0.6	-1.7	0.2	-0.9	1.0	-2.0	-1.6	-1.3	0.9
Relative age of first facial hair	0.6	1.2	2.1	0.2	-1.3	-0.3	-1.4	1.1	-1.4	1.3	1.0	-1.2	-1.0
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	7.3	2.7	-0.2	-2.0	1.2	-1.1	-0.1	-1.4	-0.8	-2.7	-0.3
Ever used hormone-replacement therapy (HRT)	1.8	2.3	6.0	-0.9	2.3	-0.5	0.7	-1.5	1.9	-0.1	-2.4	1.3	-1.6
Ever had hysterectomy (womb removed)	2.2	2.5	5.5	0.4	1.8	-1.9	0.6	-1.7	2.3	-1.2	-1.6	-2.3	-0.1
Systolic blood pressure, automated reading	0.3	0.8	5.5	-0.5	-0.7	-0.5	0.1	0.4	-0.4	0.9	-0.4	0.4	-2.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.3	0.4	1.4	-1.3	0.5	-1.2	0.7	-1.4	-0.9	-1.5	0.8
Angina	0.4	0.5	1.2	1.1	1.1	-0.3	1.1	-0.5	0.4	-0.1	-0.6	-0.6	0.2
Medication for hormone replacement therapy	0.6	0.6	1.3	-0.4	1.0	-0.7	0.2	-0.9	0.5	-1.0	-1.1	-1.1	0.1
Vitamin and mineral supplements	2.1	2.8	13.7	-0.1	-3.7	1.0	-2.4	1.4	-2.1	0.8	0.9	-0.2	-0.1
Supplements: Zinc	0.3	0.4	1.0	-0.7	1.0	0.3	0.5	-0.4	1.0	0.5	0.4	0.4	0.2
Medication: Co-codamol	0.4	0.5	1.6	-0.6	0.5	1.0	-0.2	-0.6	0.4	-0.8	-0.9	1.2	0.0
Medication: Metformin	0.4	0.6	1.5	-1.1	1.1	0.1	1.2	-0.5	0.2	-0.7	-0.0	-1.0	0.5
Diabetes (father)	0.5	0.6	2.9	-0.3	-0.2	0.2	0.7	-0.3	0.5	-0.1	-0.7	1.7	-1.2
Diabetes (mother)	0.4	0.6	1.2	-0.6	-1.1	-0.4	0.7	-0.1	-0.6	-1.0	-0.7	-1.1	-0.7
Severe depression (siblings)	0.3	0.4	1.0	1.0	-0.4	-0.5	-0.1	0.4	-0.2	-0.1	0.8	-0.7	0.9
Pack years adult smoking proportion	0.5	0.8	3.8	0.2	0.9	-0.8	1.9	-0.1	0.3	-0.3	-0.9	-0.4	1.1
Impedance of leg (right)	0.4	2.1	4.9	1.3	-2.2	0.3	-1.8	2.0	-1.9	0.6	0.2	-1.6	-0.8
Leg fat-free mass (left)	0.6	3.2	10.6	-0.2	3.3	-1.1	2.4	-2.4	2.5	-0.8	-0.9	0.8	1.0
Trunk fat percentage	0.4	1.5	4.1	0.3	0.2	1.4	2.0	0.9	-1.1	2.0	0.4	1.4	1.0
Hand grip strength (right)	0.3	0.8	5.0	0.8	0.1	-0.5	-0.4	-0.3	0.9	-0.0	-0.5	0.8	-2.2
Townsend deprivation index at recruitment	0.7	1.0	5.1	2.2	0.6	-1.5	0.6	0.1	0.8	-0.3	-1.0	-0.4	0.0
Current tobacco smoking	0.7	1.1	3.6	-0.9	1.5	-0.4	1.9	-1.0	1.5	-0.4	-0.5	-0.4	-0.7
Average weekly fortified wine intake	0.6	0.7	3.8	-0.2	0.2	0.6	1.0	0.4	-0.3	0.2	0.9	0.7	1.9
Maternal smoking around birth	1.0	1.5	5.5	2.4	-0.2	-1.2	-1.9	0.5	0.4	-0.0	-0.7	-1.7	0.8
Fed-up feelings	0.5	0.8	2.3	0.7	1.2	-0.8	0.8	-0.8	0.3	-1.5	-0.2	-1.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.6	0.6	-0.1	1.3	-0.9	0.1	-0.0	-0.3	0.1	-0.1	-0.0
Relative age voice broke	0.2	0.3	1.6	-0.6	-0.2	0.1	-1.3	0.2	-0.6	0.6	-0.4	-0.0	0.1
Taking other prescription medications	1.2	1.8	5.9	0.1	0.1	-1.7	2.4	-1.0	-0.2	-1.0	-0.6	-2.0	-1.6
Age when periods started (menarche)	0.4	1.0	4.0	0.8	-0.8	0.7	-0.4	0.6	-0.6	0.5	0.9	-1.4	-2.0
Bilateral oophorectomy (both ovaries removed)	4.0	4.7	9.9	-0.7	1.5	-3.1	2.1	-2.9	2.7	-2.0	-2.7	-1.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.6	0.4	0.4	0.4	1.3	-0.5	1.1	-0.2	-0.6	1.1	0.2
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.8	-2.2	0.1	0.2	1.6	-0.7	1.0	0.4	-1.2	1.9	1.2
Qualifications: CSEs or equivalent	1.4	1.9	7.5	2.7	-1.6	-0.3	-0.6	0.7	0.1	0.0	0.4	-2.5	1.3
Serious illness, injury or assault to yourself	0.7	0.8	2.8	-0.4	1.5	0.8	0.9	0.1	-0.3	-0.1	1.1	0.5	1.7
High blood pressure	0.3	0.7	2.9	-0.2	-0.4	-0.8	1.7	-0.7	0.7	-0.4	-1.0	-0.9	-0.2
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.0	-1.0	0.0	0.7	-1.0	0.9	-0.3	1.5	1.0	2.0	-0.2
Multivitamins +/- minerals	1.1	1.3	4.4	0.5	2.1	-1.2	2.1	-0.7	1.0	-0.8	0.0	-0.7	0.3
Stomach or abdominal pain in last month	0.2	0.2	1.2	-1.1	-0.2	-0.5	0.6	-0.3	0.5	0.2	-0.4	-0.0	0.1
Supplements: Glucosamine	1.1	1.4	8.6	-1.4	0.8	0.3	2.9	-0.1	0.2	0.3	1.1	0.7	1.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.8	0.9	0.8	-0.7	1.9	-1.0	0.9	-0.3	-0.7	-1.1	0.7
Medication: Atenolol	1.0	1.3	4.9	-2.0	1.7	0.8	2.2	-0.2	-0.2	0.5	-0.5	-0.2	-0.0
Medication: Levothyroxine sodium	0.8	1.4	3.5	0.4	0.1	-1.9	1.6	-1.6	0.8	-1.3	-1.5	-0.2	-0.7
Sitting height	0.2	1.5	7.3	-0.6	2.7	-0.4	0.1	-1.2	1.9	0.1	-1.0	0.4	1.1
Chronic bronchitis/emphysema (father)	1.3	1.5	4.0	-1.7	-1.4	1.0	-2.0	0.8	-1.5	0.1	0.1	-0.3	-1.5
High blood pressure (mother)	0.6	0.9	3.2	-1.2	-0.9	-0.8	0.2	-0.7	0.1	-1.3	-0.3	-0.9	1.8
Body mass index (BMI)	0.3	1.2	4.2	-0.4	0.6	0.9	1.9	0.3	-0.1	1.5	0.7	2.1	0.4
Impedance of leg (left)	0.4	2.0	4.4	1.5	-2.1	0.0	-1.7	1.9	-1.8	0.9	-0.1	-1.4	-0.4
Leg predicted mass (left)	0.6	3.4	11.1	-0.3	3.3	-1.1	2.3	-2.5	2.6	-0.9	-1.0	0.8	0.9
Trunk fat mass	0.3	1.3	7.5	0.2	1.3	0.4	2.7	-0.2	0.1	1.1	-0.1	1.2	1.0
Waist circumference	0.1	0.5	3.6	0.2	0.6	0.1	1.9	-0.2	-0.1	0.8	0.3	0.4	0.7
Number of incorrect matches in round	1.1	1.8	2.9	-0.1	1.5	-1.6	1.7	-1.6	1.4	-1.4	-1.7	-0.6	-0.9
Past tobacco smoking	0.5	0.9	5.0	0.9	0.2	0.2	0.7	1.0	-0.3	1.0	0.9	2.2	-0.1
Alcohol usually taken with meals	0.4	0.7	3.4	-0.9	-0.6	0.4	-0.4	0.3	-0.2	0.3	1.2	1.9	0.7
Nervous feelings	0.6	1.2	4.6	1.7	0.4	-0.1	1.4	-0.0	0.2	-0.8	0.5	-2.1	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.5	0.5	1.1	0.9	-0.3	-0.3	0.2	-0.4	-0.2	-0.8	-1.2
Hearing difficulty/problems with background noise	0.6	1.0	3.6	1.9	-1.3	-1.4	0.5	0.2	-0.3	-0.9	0.2	-0.9	0.7
Hair/balding pattern: Pattern 2	1.7	2.2	6.2	0.9	-0.8	1.9	-2.5	1.7	-1.6	1.2	0.6	1.4	0.9
Had menopause	0.9	1.1	4.6	-1.2	2.1	0.5	-0.1	-1.0	0.6	-0.1	-1.4	0.8	-1.1
Had other major operations	1.2	1.5	3.4	-0.3	1.9	-0.2	0.5	-1.7	1.7	-1.0	-1.5	-1.5	0.2
Forced vital capacity (FVC)	0.4	1.5	4.8	-1.1	1.9	-0.4	0.7	-1.6	2.2	-0.7	-0.8	0.9	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.5	1.2	-0.7	0.0	0.8	0.1	0.2	-0.3	-0.3	0.4	0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.0	-0.3	-1.0	-0.3	0.2	-0.0	-0.7	-0.4	0.0	-0.1	-0.6
Qualifications: None of the above	0.2	0.4	1.2	0.3	0.8	-0.4	0.6	-0.1	1.1	-0.3	-1.1	-0.5	0.5
Financial difficulties in last 2 years	1.7	2.3	8.8	-0.8	3.0	-0.2	2.0	-1.5	2.6	0.1	-0.3	0.7	0.4
Mouth/teeth dental problems	0.5	0.8	3.0	-1.1	-0.8	-0.4	-1.7	0.2	-0.4	-0.3	0.4	-0.7	-1.4
Heart attack	0.3	0.4	1.9	-1.0	0.3	0.3	1.4	0.4	-0.6	0.3	0.6	-0.1	0.6
Allergy	0.1	0.3	1.4	0.9	-0.4	0.1	0.2	-0.1	-0.1	-0.7	-0.1	-1.2	0.3
Pain all over the body in last month	0.4	0.4	1.9	-0.2	1.4	0.5	-0.1	-0.2	0.1	-0.7	0.0	-0.3	1.1
Diabetes (self-reported)	0.5	0.7	2.7	-1.6	1.4	0.7	1.2	-0.3	0.3	-0.2	0.3	0.2	0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	-1.4	-0.7	-1.0	-0.3	-0.1	0.2	0.1	0.2	0.0	-1.2
Medication: Ramipril	1.2	1.5	5.3	2.1	1.7	-0.6	0.9	-0.2	0.2	-0.3	-0.1	-2.3	0.9
Medication: Simvastatin	0.7	1.1	3.3	1.4	1.5	-0.7	1.2	-0.5	1.0	-0.7	0.3	-1.8	-0.3
Fluid intelligence score	0.7	1.4	7.2	-0.8	-0.4	1.5	-0.4	0.9	-0.6	1.4	-0.1	2.7	-1.0
Illnesses of siblings	0.8	1.1	3.4	0.1	1.2	0.5	-1.8	0.1	0.9	1.8	-0.7	1.2	-0.2
Neuroticism score	0.2	0.5	1.2	0.7	0.9	1.1	0.5	0.4	-0.1	-0.0	0.8	-0.8	0.7
Weight	0.4	2.1	8.2	-0.2	2.3	-0.6	2.9	-1.4	1.6	0.3	-0.6	1.2	0.6
Impedance of arm (right)	0.7	3.1	6.8	1.0	-1.8	2.6	-2.1	2.0	-2.1	1.5	0.9	-0.4	1.9
Arm fat percentage (right)	0.5	1.8	4.4	0.3	0.0	2.0	1.2	1.2	-1.0	2.1	0.9	1.8	1.5
Trunk fat-free mass	1.1	6.3	14.6	0.1	3.8	-2.9	2.5	-3.3	3.7	-2.1	-1.6	-0.9	0.4
Hip circumference	0.3	1.1	3.3	-0.5	0.8	0.3	1.8	-0.1	0.1	1.2	0.5	1.6	1.5
Time employed in main current job	3.0	3.4	6.2	-0.0	-2.5	2.2	-1.1	2.1	-2.3	2.0	2.5	1.4	0.3
Alcohol intake versus 10 years previously	0.5	0.8	3.2	-0.0	0.2	-0.7	-1.6	-0.7	0.4	-0.8	-0.4	-1.8	0.3
Father’s age at death	0.4	0.5	2.9	-0.2	0.7	-0.2	1.7	-0.5	0.3	0.3	-0.3	1.0	-0.1
Worrier / anxious feelings	0.2	0.3	1.2	0.3	-0.8	0.8	0.0	0.0	-0.4	-0.6	0.3	-1.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.1	0.5	1.2	-0.4	1.5	-0.7	0.8	-0.7	0.0	-1.4	0.9
Falls in the last year	1.3	1.7	5.0	1.3	-1.2	1.4	0.1	1.3	-0.7	1.5	0.4	2.2	1.5
Hair/balding pattern: Pattern 3	0.4	0.5	1.1	-0.4	0.4	-0.9	0.5	-1.0	0.8	-1.1	-0.8	-0.0	0.7
Number of live births	0.5	0.7	3.9	2.0	1.2	-0.6	-0.1	0.2	0.0	-0.4	-0.9	-0.4	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	3.0	-0.6	0.5	1.2	-0.0	-0.1	0.7	0.6	0.4	1.7	1.1
Pulse rate	0.5	0.9	2.1	0.5	1.2	1.5	0.8	0.8	-1.2	0.8	1.1	0.2	-0.6
Happiness	2.7	3.3	8.0	-2.1	1.6	-0.9	2.8	-2.1	2.2	-1.2	-1.2	0.7	-2.2
Noisy workplace	0.6	0.7	1.7	0.6	1.0	-1.1	0.1	-0.9	0.7	-0.7	-1.3	-0.3	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.9	-1.4	-0.4	0.6	-0.9	0.6	-0.3	1.2	0.9	0.7	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.9	-1.7	0.6	-0.0	-0.6	-0.5	0.4	-1.0	0.3	0.8	-0.1
Mouth/teeth dental problems: Dentures	0.7	1.1	6.1	1.8	-0.4	1.0	-0.5	0.4	0.0	0.0	-0.3	0.7	2.5
Asthma	0.2	0.4	1.5	0.5	-1.2	0.5	-0.8	0.6	-0.8	0.2	0.0	0.0	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.9	1.7	-0.7	-0.2	1.1	0.1	-0.7	0.3	-0.2	-0.8	0.2
Medication: Cholesterol lowering	1.3	2.0	6.7	0.7	1.2	-1.0	2.2	-1.2	0.5	-1.3	0.6	-2.6	1.4
Depression (self-reported)	0.6	0.7	5.1	2.3	0.3	-0.4	0.3	-0.1	0.7	-0.3	0.4	0.5	0.5
Medication: Lansoprazole	0.8	0.9	5.0	-0.2	0.1	-1.0	0.7	-0.4	-0.7	-1.2	0.3	-2.2	0.4
Prospective memory result	1.1	1.4	4.9	-0.3	1.0	-1.4	1.5	-0.6	1.0	-0.5	-1.0	-1.0	-2.2
Lung cancer (father)	0.7	0.8	2.2	0.4	1.5	1.2	0.5	0.7	-0.2	0.4	0.4	1.5	1.1
Illnesses of mother	1.2	1.5	4.3	0.6	0.9	1.9	-0.4	1.1	-0.5	2.1	0.7	1.9	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.7	-0.3	0.5	1.3	-0.0	-0.1	0.8	0.7	0.4	1.3	0.6
Pulse wave Arterial Stiffness index	0.3	0.4	2.0	1.4	0.4	-0.2	-1.0	0.4	-0.1	0.5	-0.1	-0.4	-0.0
Impedance of arm (left)	0.8	3.5	7.9	0.7	-1.9	2.8	-2.0	2.4	-2.6	1.8	1.2	0.2	1.2
Arm fat mass (right)	0.3	1.2	3.1	0.2	1.3	0.8	1.8	0.0	0.4	1.4	0.1	1.8	1.2
Trunk predicted mass	1.1	6.1	14.4	0.2	3.8	-2.9	2.4	-3.3	3.7	-2.1	-1.5	-1.0	0.4
Standing height	0.7	6.7	14.7	0.6	3.8	-2.9	1.9	-3.4	3.7	-2.3	-2.4	-1.6	0.8
Length of working week for main job	0.6	0.7	1.9	-0.4	0.6	-0.3	0.9	-1.3	1.4	-1.1	-0.5	-0.3	-0.5
Exposure to tobacco smoke at home	1.3	1.4	4.4	-0.5	0.5	-1.9	2.1	-1.4	1.0	-0.7	-0.7	-0.4	-1.3
Breastfed as a baby	0.8	1.0	3.3	-1.8	-0.0	-1.2	0.9	-0.8	0.4	-0.8	0.2	-1.6	0.2
Tense / ‘highly strung’	0.6	1.0	2.5	1.2	1.4	-0.0	1.3	0.2	0.1	-0.4	0.5	-1.4	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	7.8	0.7	2.8	-1.0	1.4	-1.8	1.9	-1.5	-1.1	-0.1	-0.9
Hair/balding pattern: Pattern 4	0.5	1.2	2.4	0.9	-1.2	1.5	0.7	1.4	-0.8	1.2	1.6	0.6	0.7
Birth weight of first child	2.4	4.3	8.0	-0.2	0.8	-2.8	0.2	-2.6	2.3	-2.6	-2.1	-2.6	2.1
Peak expiratory flow (PEF)	0.7	1.5	3.3	-1.0	0.4	1.8	0.0	1.3	-0.6	1.7	1.2	1.8	1.1
Pulse wave reflection index	0.4	0.5	1.4	0.5	-0.1	-0.6	-0.8	-0.4	1.2	0.5	-1.0	0.6	-0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.8	1.9	-1.1	0.3	1.1	-0.3	0.9	0.1	-0.9	1.8	1.0
Loud music exposure frequency	0.6	0.7	1.6	-0.1	1.3	-0.3	1.2	-0.5	1.0	0.8	-0.1	0.6	-1.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	-0.5	0.5	-0.2	-0.1	-0.6	0.6	0.0	0.1	0.9	-0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.7	0.1	0.9	0.7	1.6	-0.0	-0.1	0.2	0.8	-0.2	1.2
Blood clot in the leg (DVT)	0.9	1.2	2.2	-1.2	1.3	-1.1	1.5	-1.5	1.3	-0.3	-1.2	-0.4	-0.4
Medication: Paracetamol	0.5	0.9	2.3	-0.4	1.2	-0.3	1.0	-1.2	1.1	-0.8	-1.5	-0.5	0.7
Headache pain in last month	0.2	0.4	1.4	-0.8	0.2	-0.2	1.2	0.3	-0.2	0.1	-0.9	0.5	0.7
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	17.3	-1.4	-0.7	1.6	-2.1	1.3	-0.6	1.9	0.0	4.2	-1.5
Glaucoma (self-reported)	1.0	1.2	4.3	1.1	-1.1	-0.9	-1.4	-0.3	0.1	-0.6	-1.1	-1.1	-2.1
Gout (self-reported)	0.7	1.0	5.0	-0.0	0.0	1.3	0.5	0.7	-0.5	0.6	0.3	2.2	1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.9	-0.9	0.1	-0.8	1.3	-1.7	0.6	-1.7	-1.7	0.6	-0.6
Medication: Amlodipine	0.4	0.6	2.1	0.9	-1.1	-0.5	0.5	0.1	-0.7	-0.0	-0.2	-1.5	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.3	-0.0	0.3	-1.5	-0.3	-0.4	0.9	0.1	-1.5	1.2	-0.3
Birth weight	0.6	1.2	3.3	0.2	1.8	-1.1	1.7	-1.1	1.2	-0.5	-1.3	-0.2	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	-0.8	-0.1	0.5	-0.2	-0.4	0.4	-0.1	-0.7	0.4	-0.9
High blood pressure (siblings)	0.7	1.0	3.7	-0.3	-0.7	-0.5	1.5	-0.4	-0.3	-1.9	0.7	-1.1	1.2
Forced vital capacity (FVC), Best measure	0.4	1.3	4.6	-1.1	1.8	0.2	0.5	-1.4	2.2	-0.3	-0.6	1.1	0.3
Body fat percentage	0.4	1.4	3.7	0.2	0.1	1.4	1.9	0.9	-0.9	1.9	0.4	1.6	1.0
Leg fat percentage (right)	0.3	1.1	3.1	0.2	-0.3	1.0	1.8	0.9	-0.8	1.5	0.6	1.5	-0.6
Arm fat-free mass (right)	1.3	6.4	16.4	-0.5	4.0	-2.9	2.8	-3.4	3.5	-2.0	-1.9	-0.2	-0.3
Exposure to tobacco smoke outside home	0.7	1.0	2.8	-0.1	1.4	-0.9	1.7	-1.0	0.7	-1.2	-0.0	-0.9	0.8
Comparative body size at age 10	0.4	1.0	3.4	0.6	1.0	0.2	1.8	0.3	-0.6	0.5	1.4	-0.2	1.8
Number of full brothers	1.2	1.5	6.9	-1.3	-2.6	0.0	-0.4	-0.5	-0.9	-1.2	0.4	-1.6	-0.7
Worry too long after embarrassment	0.7	1.1	3.1	0.2	0.9	-0.1	1.8	-1.3	0.8	-1.6	-0.5	-1.5	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	6.2	2.4	1.3	-1.7	0.6	-1.5	0.8	-2.2	-0.9	-2.5	-0.5
Wheeze or whistling in the chest in last year	0.5	0.9	2.3	-0.6	-0.1	-1.4	1.3	-0.9	1.0	-0.4	-1.5	0.5	-0.8
Number of children fathered	0.5	0.5	1.8	-0.7	-0.5	-0.3	0.2	-0.6	0.1	-1.1	-1.3	0.9	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.5	1.0	-0.3	1.5	-1.0	1.1	-0.4	2.1	0.9	0.3	1.0
Age at first live birth	0.7	1.2	3.6	0.0	-0.7	1.7	-1.0	0.6	-0.4	0.6	1.7	1.9	0.0
Pulse wave peak to peak time	0.4	0.5	2.3	-1.5	-0.2	-0.1	1.1	-0.7	0.4	-0.7	-0.2	0.2	0.1
Health satisfaction	1.9	2.4	11.2	-1.3	2.1	-1.8	3.4	-1.2	0.8	-0.9	-0.7	-0.2	-0.8
Shortness of breath walking on level ground	0.3	0.4	3.1	-0.1	0.2	0.0	0.2	0.0	0.3	0.8	-0.2	0.3	-1.8
Qualifications: College or University degree	0.2	0.6	3.3	-1.1	0.2	0.1	-0.1	0.2	-0.2	0.6	1.0	1.8	-0.4
Eye problems/disorders: None of the above	0.4	0.5	1.5	0.4	0.9	-0.8	1.2	-0.2	0.0	-0.7	0.4	0.0	1.1
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.3	1.1	0.8	-0.2	1.5	0.5	-0.7	0.5	1.1	0.5	-1.1
Emphysema/chronic bronchitis	0.4	0.5	3.1	-1.8	-0.1	-0.0	0.1	-0.6	0.2	-0.4	-0.7	0.3	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	4.6	-0.1	-0.4	0.9	-2.1	0.7	-0.1	0.3	1.1	0.8	0.5
Neck or shoulder pain in last month	0.7	1.0	3.9	0.8	0.6	-1.1	2.0	-0.5	0.6	-0.7	-0.0	-1.5	0.5
Medication: Blood pressure	1.6	2.8	16.2	1.9	0.1	-0.6	1.6	-0.3	-0.2	-0.8	0.8	-4.0	1.8
Angina (self-reported)	0.4	0.5	1.6	1.1	1.2	-0.2	1.3	-0.5	0.4	-0.1	-0.7	-0.2	0.4
Migraine (self-reported)	1.3	1.6	3.3	-0.7	1.3	-1.1	1.7	-1.3	1.8	-0.5	-1.3	-1.0	-1.5
Medication: Ibuprofen	0.3	0.3	1.3	0.6	0.2	-0.6	1.2	-0.4	-0.2	-0.1	-0.6	-0.7	0.1
Medication: Allopurinol	0.5	0.7	1.9	-1.3	1.4	0.5	1.1	-0.4	-0.2	-0.3	-0.2	1.3	0.4
Medication: Omeprazole	1.4	1.7	4.5	-1.5	1.5	0.5	1.6	-0.9	1.2	-0.0	-1.7	2.1	-0.3
Medication: Seretide 50 evohaler	0.5	0.6	1.4	-0.8	-0.3	-0.7	-0.1	-1.0	0.6	-0.8	-1.2	-0.6	-0.8
Mean time to correctly identify matches	1.5	2.9	5.4	2.3	1.1	-2.2	1.1	-1.7	2.2	-1.1	-1.7	-2.0	0.4
Heart disease (mother)	1.2	1.4	4.3	-1.3	-1.8	0.0	-1.5	0.2	-1.2	-0.4	1.1	-2.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	-1.1	0.7	1.0	0.7	0.6	-0.2	0.8	1.3	0.9	0.6
Whole body fat mass	0.3	1.2	6.4	0.4	1.4	0.3	2.5	-0.2	0.4	1.0	-0.3	1.2	1.0
Leg fat mass (right)	0.2	0.9	5.3	0.0	1.1	0.2	2.3	-0.4	0.5	0.6	-0.3	1.2	0.3
Arm predicted mass (right)	1.2	6.2	16.7	-1.0	4.1	-2.7	2.7	-3.3	3.4	-1.9	-1.8	0.1	-0.5
Pulse rate, automated reading	0.4	1.1	3.0	-0.3	0.7	1.7	-0.1	1.1	-1.4	1.4	1.2	1.0	-0.7
Alcohol intake frequency.	0.9	2.1	4.0	0.6	1.1	-2.0	1.6	-1.5	1.6	-1.5	-1.6	-1.7	-0.7
Comparative height size at age 10	0.6	3.2	9.8	0.0	3.1	-1.5	1.9	-2.2	2.7	-1.1	-1.6	-0.4	-0.9
Number of full sisters	1.7	2.0	8.0	0.9	0.0	-1.6	-0.1	-1.2	0.3	-2.8	-1.4	-2.4	0.4
Suffer from ‘nerves’	0.8	1.3	6.2	2.5	0.6	0.2	0.0	0.7	-0.4	-0.2	0.7	-0.8	2.2
Overall health rating	1.2	2.6	10.7	0.5	2.7	-1.2	3.3	-1.1	1.1	-0.8	-1.1	-1.1	0.8
Chest pain or discomfort	0.7	1.0	8.9	-0.1	0.4	-0.1	3.0	-0.2	0.5	0.8	0.3	0.2	0.3
Had major operations	0.5	0.6	1.8	0.2	0.5	-0.1	1.1	0.3	-0.6	-1.0	1.0	-0.4	1.4
Age at last live birth	0.4	0.6	1.8	1.3	0.2	0.8	-0.5	0.4	-0.0	0.2	1.3	1.0	-0.2
Family relationship satisfaction	2.2	2.7	7.5	-0.4	2.1	-0.5	2.7	-1.7	2.0	-0.8	-1.5	2.2	0.4
Leg pain on walking	0.9	1.1	4.4	-0.8	0.4	-1.2	2.1	-0.5	0.3	-1.0	-0.6	1.0	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	5.0	0.8	-0.5	-0.6	0.1	-0.4	-0.3	-0.8	-0.7	-2.2	-0.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.3	0.2	-0.9	1.7	-1.3	1.4	-1.2	2.1	0.9	1.0	1.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	6.4	0.7	-1.9	-1.2	-1.6	-0.5	0.0	-0.6	-1.8	-0.6	-2.5
Medication: Aspirin	1.4	1.9	7.4	0.8	-0.1	-1.9	1.5	-1.1	0.7	-1.4	-0.6	-2.7	-0.5
Supplements: Vitamin C	3.8	4.5	10.8	-1.2	3.1	-1.6	1.9	-2.6	3.3	-1.6	-2.6	-0.1	0.9
Knee pain experienced in last month	1.5	2.3	13.6	-1.1	1.4	-0.3	3.7	-1.3	0.5	-1.4	0.4	-0.7	1.3
Hypertension (Self-reported)	0.4	1.0	3.9	-0.3	-0.3	-0.9	2.0	-1.0	0.8	-0.9	-1.0	-1.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	7.6	-1.1	2.8	-1.9	2.2	-1.7	1.2	-1.3	-1.8	0.9	-1.3
Illnesses of father: Heart disease	0.2	0.2	0.6	-0.1	0.7	-0.5	-0.3	-0.5	0.1	-0.6	-0.1	-0.5	-0.8
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.3	-0.7	-0.2	0.6	0.5	-0.6	-0.5	-0.1	-0.4	0.6
Smoking status: Previous	0.5	0.8	3.8	-0.5	-0.3	0.0	-1.3	-0.7	0.1	-1.0	-0.7	-1.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	-1.0	0.8	0.6	-0.0	-0.3	0.9	-0.0	0.9	0.4	0.0
Whole body fat-free mass	0.9	5.2	14.4	-0.1	3.8	-2.4	2.6	-3.1	3.4	-1.6	-1.4	-0.3	0.6
Leg fat-free mass (right)	0.7	3.8	12.3	-0.3	3.5	-1.2	2.4	-2.5	2.7	-0.8	-1.0	0.9	1.2
Arm fat percentage (left)	0.6	2.2	5.5	-0.0	0.3	2.2	1.4	1.2	-1.1	2.3	0.9	2.4	1.1
Average weekly red wine intake	1.0	1.4	5.3	-1.0	0.9	2.1	0.5	0.3	-0.5	1.4	0.5	2.3	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.5	-0.6	-0.2	0.7	0.4	-0.4	0.5	-0.2	-0.5	0.1	-0.1
Mood swings	0.2	0.3	1.5	0.6	0.8	0.0	-0.4	-0.3	0.5	-0.2	0.2	-1.2	0.5
Loneliness, isolation	0.4	0.6	1.9	0.8	1.0	0.2	0.5	-0.8	1.4	-0.5	-1.1	-0.2	0.2
Long-standing illness, disability or infirmity	0.8	1.2	4.8	0.3	1.5	-1.0	1.9	-0.5	0.0	-0.2	-0.2	-2.2	0.1
Ever had bowel cancer screening	0.9	1.0	5.6	1.7	0.6	-0.9	2.4	-0.0	-0.1	0.4	-0.3	-0.1	0.4
Diabetes diagnosed by doctor	0.5	0.8	2.4	-1.5	1.6	0.0	1.3	-0.7	0.6	-0.6	0.2	-0.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	5.0	0.8	-0.7	-0.8	1.3	0.3	-0.4	-0.0	0.0	-1.1	-2.2
Friendships satisfaction	0.2	0.3	1.3	-0.5	0.4	0.3	0.2	-0.3	0.2	-0.3	-0.6	1.1	-0.5
Qualifications: nursing, teaching	1.3	2.0	7.4	0.5	-2.0	0.6	-0.4	1.3	-1.7	1.5	0.7	2.7	0.5
Commuting to job workplace: Walk	0.7	0.7	4.5	-2.1	-0.2	1.1	-0.8	-0.4	-0.1	-0.2	0.4	0.4	0.2
Eye problems/disorders: Cataract	0.5	0.5	1.5	-1.2	-0.1	0.2	-0.7	-0.5	0.7	0.3	-0.7	0.9	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.2	0.4	0.7	-1.4	1.3	-0.7	0.6	-0.2	-1.5	0.3	0.2
Medication for cholesterol	0.9	1.3	4.9	1.4	-0.7	0.9	-0.4	0.8	-1.1	0.3	1.5	0.4	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.8	1.1	-1.3	0.8	0.3	1.7	-1.0	1.6	1.3	-1.4	0.8
Back pain experienced in last month	1.3	1.9	3.5	0.8	1.8	-1.3	1.9	-1.5	1.8	-1.3	-1.0	-0.8	0.7
Mineral and other dietary supplements	1.2	1.6	6.5	-0.0	-1.8	1.2	-2.5	0.8	-1.1	0.3	0.2	0.4	-1.8
Breast cancer (self-reported)	1.8	2.2	5.4	-0.3	-0.4	1.9	-2.3	1.6	-1.4	1.6	2.2	-0.4	-0.8
Asthma (self-reported)	0.1	0.2	1.0	0.3	-1.0	0.2	-0.4	0.4	-0.6	0.1	-0.1	-0.1	-0.2
Osteoporosis (self-reported)	0.7	0.9	2.3	1.2	-0.5	-0.5	1.2	-0.6	0.2	-1.5	0.1	-1.0	1.4
Osteoarthritis (self-reported)	0.8	1.0	4.1	-0.7	1.7	0.9	2.0	-0.1	0.4	0.2	-0.3	0.5	1.2
Medication: Aspirin	1.2	1.5	5.7	0.8	-0.1	-1.5	1.8	-1.0	0.9	-0.8	-0.6	-2.4	-0.4
Medication: Gliclazide	0.7	0.8	3.5	-1.9	0.8	1.2	0.7	-0.4	0.7	0.3	-0.1	0.8	-0.8
Illnesses of father: None of the above (group 1)	1.6	2.0	5.1	1.8	-0.2	0.9	0.6	1.2	0.3	2.3	1.1	1.7	2.1
Smoking status: Current	1.0	1.5	3.8	-1.7	1.7	-0.2	1.9	-1.3	1.6	-0.4	-1.0	-0.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	2.3	0.6	1.1	-0.9	-0.7	-0.3	1.3	-0.1	-0.1	-0.3	1.5
Whole body water mass	0.9	5.2	13.8	-0.0	3.7	-2.4	2.6	-3.1	3.4	-1.6	-1.4	-0.3	0.5
Leg predicted mass (right)	0.7	3.7	12.0	-0.3	3.5	-1.2	2.4	-2.5	2.6	-0.8	-1.1	1.0	1.2
Arm fat mass (left)	0.3	1.3	3.7	-0.0	1.5	0.9	1.9	0.0	0.3	1.3	-0.0	1.8	1.0
Number of self-reported non-cancer illnesses	1.5	2.7	8.0	0.8	1.0	-2.3	2.8	-1.6	1.3	-1.4	-1.2	-1.5	-1.3
Average weekly champagne plus white wine intake	2.5	3.5	8.9	-1.7	0.1	3.0	-1.0	1.6	-1.3	2.4	1.9	2.4	1.7
Miserableness	0.5	0.9	3.7	-1.0	1.9	0.3	1.5	-0.1	0.1	-0.3	0.5	-0.2	1.0
Guilty feelings	0.3	0.5	2.6	0.5	1.6	1.1	0.3	-0.4	0.6	-0.1	-0.2	0.2	0.7
Wears glasses or contact lenses	1.2	1.4	2.5	0.1	1.3	-1.5	1.3	-1.5	0.3	-1.6	-1.4	-1.0	-0.9
Ever taken oral contraceptive pill	2.8	3.1	7.3	-0.8	0.7	-2.7	1.9	-2.3	1.8	-2.3	-0.9	-1.9	-0.9
Hearing aid user	1.2	1.3	3.0	0.6	-0.0	-1.7	1.5	-1.0	0.3	-1.7	-0.8	-1.3	-1.2
Mother’s age at death	2.9	3.6	8.0	-1.5	1.0	-1.7	1.6	-2.4	2.3	-1.7	-2.8	1.2	-1.9
Financial situation satisfaction	1.7	2.2	9.3	-1.3	0.6	1.0	3.0	0.5	0.0	1.4	0.4	2.6	-0.0
Tinnitus: Yes, now most or all of the time	1.9	2.2	5.6	0.2	1.3	-1.0	-0.8	-1.6	2.4	-2.0	-2.0	-1.4	0.0
Commuting to job workplace: Public transport	1.6	2.0	4.0	0.2	1.1	-2.0	1.2	-1.8	1.7	-1.6	-1.4	-1.0	-1.3
Eye problems/disorders: Glaucoma	0.6	0.7	5.6	0.8	-0.6	-0.2	-0.3	0.5	-0.3	0.5	-0.6	-0.1	-2.4
Medication: Blood pressure	0.6	1.1	4.9	-1.9	0.5	0.7	0.6	-0.2	0.3	0.4	-0.0	0.8	-2.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.3	0.4	0.2	0.5	1.1	0.1	-0.5	0.0	0.3	0.3	0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.1	3.8	0.2	1.6	-0.9	1.9	-0.7	1.2	-0.2	-1.1	-0.4	1.0
High cholesterol (Self-reported)	0.4	0.7	2.2	1.5	0.6	-0.5	0.6	-0.2	-0.1	-1.0	1.0	-1.4	-0.5
Medication: Bendroflumethiazide	0.7	1.1	2.8	-0.7	-1.1	1.3	1.2	0.9	-0.3	1.7	0.5	1.4	-0.7
Medication: Paracetamol	0.4	0.5	1.4	-0.0	1.2	0.2	1.1	-0.8	1.0	-0.1	-0.8	-0.3	0.7
Medication: Lisinopril	0.3	0.4	1.0	0.7	1.0	0.3	0.4	-0.1	0.9	-0.9	-0.2	0.1	1.0
Medication: Atorvastatin	0.6	0.7	4.2	0.7	0.1	-1.0	0.8	-0.6	-0.4	-0.5	-0.4	-2.0	0.1
Illnesses of father: High blood pressure	0.5	0.6	2.6	-0.6	-0.4	0.1	1.0	-0.1	-0.9	-0.9	0.4	-0.8	1.6
Alcohol drinker status: Never	2.1	2.6	7.2	1.3	0.9	-2.7	0.8	-1.3	1.9	-1.3	-2.6	-0.3	-1.3
Ever smoked	0.4	0.7	4.6	-0.7	-1.1	0.1	-0.5	-0.1	-0.4	-0.6	0.2	-2.1	0.2
Basal metabolic rate	0.8	4.7	12.8	-0.1	3.6	-2.0	2.7	-2.8	3.2	-1.2	-1.4	0.2	0.7
Leg fat percentage (left)	0.3	1.1	3.9	0.2	-0.3	0.8	2.0	0.8	-0.7	1.6	0.3	1.7	-0.3
Arm fat-free mass (left)	1.0	5.1	13.5	-0.2	3.7	-2.5	2.7	-2.9	3.3	-1.5	-1.5	-0.2	0.4
Number of operations (self-reported)	2.0	2.9	6.1	-0.2	2.1	-1.5	2.5	-2.0	1.8	-1.9	-1.9	-1.2	0.9
Average weekly beer plus cider intake	1.7	2.4	11.2	1.2	-3.3	0.3	-0.8	0.9	-0.7	0.1	1.1	-2.5	-1.3
Irritability	0.3	0.5	1.0	-0.6	1.0	0.7	0.6	-0.6	0.9	-0.1	-1.0	0.7	0.2
Risk taking	0.1	0.2	0.5	-0.1	-0.3	-0.2	-0.5	0.3	-0.7	-0.6	0.3	-0.7	-0.1
Ever had prostate specific antigen (PSA) test	2.1	2.4	6.1	1.5	0.6	-2.4	2.5	-1.4	0.9	-1.2	-1.0	-2.0	0.7
Fractured/broken bones in last 5 years	0.6	0.7	3.6	-0.3	0.2	-0.2	1.9	-0.2	-0.6	-0.6	1.6	0.2	0.3
Age started oral contraceptive pill	2.2	2.8	7.6	-2.6	-0.6	-1.6	0.5	-2.0	1.0	-1.4	-1.9	0.2	-2.8
Diastolic blood pressure, automated reading	0.4	1.3	5.0	-1.1	0.1	0.0	0.4	-0.2	0.2	1.3	-0.5	2.2	-2.2
Ever depressed for a whole week	1.3	1.5	3.7	-1.9	0.5	-0.5	1.6	-1.3	0.1	-1.1	-1.0	1.5	-1.6
Unable to work because of sickness or disability	0.9	1.2	3.2	0.7	1.6	-1.1	1.8	-1.0	0.3	-0.8	-0.6	-0.7	-1.5
Commuting to job workplace: Cycle	0.4	0.5	2.5	-0.5	0.7	0.2	0.5	0.3	-0.1	0.3	-0.7	0.7	-1.6
Myopia	0.7	1.0	4.8	0.0	0.7	-1.9	2.2	-0.6	0.4	0.2	-0.5	0.0	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.2	-0.2	0.6	1.3	-2.0	0.7	-0.6	0.4	0.8	1.5	0.8
Cholesterol lowering medication	0.7	1.0	2.8	1.1	1.0	-1.5	0.8	-0.2	0.6	-0.2	-0.6	-1.7	-1.3
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	4.9	-2.2	2.2	0.4	2.0	-1.3	1.3	-0.0	-1.5	2.1	-0.7
Pain experienced in last month	0.7	1.2	6.3	0.4	-0.6	0.5	-2.5	-0.0	0.2	0.9	0.2	1.1	-1.6
Supplements: Calcium	1.1	1.2	5.8	-0.8	0.6	0.6	-0.0	-0.8	1.6	-0.6	-0.8	1.0	2.4
Basal cell carcinoma (self-reported)	0.7	0.9	2.9	0.2	0.6	0.6	1.2	0.1	0.0	-0.2	-0.9	1.7	1.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.0	-0.7	0.6	0.2	1.4	0.3	-0.3	0.4	0.5	-0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.0	-1.1	1.2	-0.9	1.4	-1.2	1.0	-0.3	-0.7	-0.5	-0.2
Heart disease (siblings)	0.2	0.2	1.2	-0.8	0.1	0.3	1.1	-0.2	-0.1	-0.1	0.1	-0.5	-0.4
Alcohol drinker status: Previous	1.9	2.2	4.1	-0.9	1.4	-0.7	1.8	-2.0	1.3	-1.4	-1.2	-1.4	-2.0
Pack years of smoking	0.7	1.0	3.6	-0.3	1.1	-0.9	1.9	-0.4	0.7	-0.5	-1.5	-0.0	0.9
Impedance of whole body	0.5	2.4	5.5	0.9	-2.1	1.6	-1.6	2.2	-2.3	1.5	0.5	-0.4	0.5
Leg fat mass (left)	0.3	1.1	5.8	-0.0	1.2	0.3	2.4	-0.3	0.5	0.9	-0.3	1.4	0.4
Arm predicted mass (left)	1.0	5.3	13.3	0.0	3.6	-2.7	2.6	-3.0	3.3	-1.6	-1.7	-0.2	0.1