Hub : Genes

ZNF460

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0660	0.0250	2.5e-03	0.017	0.015	0.004	0.018	0.006	2.8e-03	5.8e-03	0.10000	2.6e-03	5.7e-02
2	NTR	Blood	0.0423	0.0137	3.3e-05	0.024	0.016	0.011	0.022	0.019	1.7e-08	5.5e-06	0.00014	9.5e-08	7.8e-07
3	TCGA	Thyroid Carcinoma	0.0450	0.0200	9.6e-04	0.040	0.017	0.030	NA	0.000	9.2e-05	7.7e-03	0.00055	NA	3.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.4	2.7	1.6	1.1	-0.5
Bipolar Disorder or Schizophrenia	0.9	2.1	3.8	2.0	1.4	-0.6
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	-0.1	-0.6	-0.1
Depression (Nagel 2018)	0.2	0.2	0.4	0.6	0.1	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	-0.1	0.4	1.0
Neuroticism (Nagel 2018)	0.3	0.6	1.3	0.2	-1.1	0.8
Schizophrenia (2018)	0.4	0.8	1.4	1.2	0.9	-0.3
Schizophrenia vs Biploar Disorder	0.4	0.6	1.6	-0.3	1.2	0.3
Worry (Nagel 2018)	0.1	0.2	0.3	-0.2	-0.5	-0.5
Alzheimer’s Disease (in mother)	1.1	1.3	2.2	-0.4	1.3	-1.5
Alzheimer’s Disease (in father)	0.8	0.8	2.2	1.5	-0.1	-0.6
Alzheimer’s Disease (including proxy)	0.8	1.2	2.7	0.7	0.6	-1.6
Crohns Disease (2017)	1.5	3.4	10.2	0.1	3.2	0.1
Irritable Bowel Disease (IBD)	1.1	2.6	7.5	-0.2	2.7	-0.5
Ulcerative Colitis (UC)	0.9	1.7	3.2	-0.6	1.8	-1.2
Major Depression (MDD)	1.9	2.3	5.8	-0.2	2.4	1.0
Reaction Time	1.9	3.6	10.2	0.4	0.7	-3.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.2	0.6	0.5
Breast Cancer	0.9	2.2	2.8	-1.7	1.2	1.5
Ovarian Cancer	2.6	3.4	7.2	-0.6	1.6	2.7
Prostate Cancer	0.5	0.8	1.1	0.2	-1.1	1.1
Age at First Birth	0.2	0.3	0.5	-0.2	-0.6	0.7
Bipolar Disorder (2011)	1.1	1.0	1.9	1.4	1.1	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.0	0.7	0.6	-1.0
Coronary Artery Disease (CAD)	1.7	2.0	4.9	-1.0	2.2	0.3
Crohns Disease (2012)	2.7	4.4	12.8	-0.5	3.6	-0.1
Mean Putamen Volume	0.1	0.1	0.3	-0.3	0.1	0.6
Fasting Glucose	1.4	1.7	3.3	-1.8	-1.4	0.3
HbA1C	0.5	0.5	1.5	-1.2	0.3	0.1
HDL Cholesterol	0.2	0.4	0.8	-0.9	0.0	0.7
LDL Cholesterol	1.0	1.7	3.5	0.4	-1.9	-1.1
Lupus	0.4	0.6	1.3	1.1	0.4	-0.5
Neuroticism (2016)	0.1	0.1	0.1	0.4	-0.4	0.1
Primary Biliary Cirrhosis	0.3	0.4	1.1	-1.0	0.3	0.5
Rheumatoid Arthritis	1.7	2.3	6.0	-2.5	1.0	0.2
Schizophrenia (2014)	0.5	1.0	1.6	1.2	1.2	-0.4
Triglycerides	0.4	0.7	1.2	0.2	-1.1	-0.9
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.5	1.6	-0.1	0.2
Ulcerative Colitis	0.7	1.0	1.5	-0.2	1.2	-1.2
Blood Eosinophil Count	0.7	5.7	8.2	-1.3	2.7	2.9
Blood Platelet Count	0.5	6.2	9.2	-2.1	3.0	-2.2
Blood Red Count	0.1	1.0	2.6	1.6	0.2	-0.5
Blood White Count	0.2	1.4	3.7	-0.1	-0.6	1.9
Heel T-Score	1.1	9.0	14.5	0.1	-3.8	3.5
BMI	0.4	2.1	4.0	0.6	1.4	2.0
Height	0.9	16.6	46.2	1.2	-6.8	1.4
Waist Hip Ratio (WHR)	1.2	5.5	8.6	-0.2	-2.9	2.8
Systolic Blood Pressure	0.4	2.2	5.3	1.1	-2.3	0.3
Smoking Status	1.6	3.9	10.3	0.8	-3.2	0.9
Allergy or Eczema	1.4	3.6	7.0	0.1	2.6	-2.0
Cardiovascular Disease	0.2	0.6	1.7	-0.0	-1.3	-0.2
Hypothyroidism (self reported)	1.2	2.7	7.7	0.1	-2.8	0.6
Respiratory disease	0.7	1.5	2.4	-1.6	1.4	-0.0
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.5	0.9	-1.6	0.7
Lung FEV1/FVC ratio	0.5	2.5	3.7	-1.3	1.4	-1.9
Lung FVC	0.6	3.1	7.3	0.3	2.7	-1.4
Neuroticism	0.4	0.9	2.5	-0.1	-1.6	0.4
Chronotype (morning person)	0.3	0.6	1.6	-1.3	0.4	-0.3
Hair Pigment	0.0	0.6	1.3	-1.2	-0.6	-0.4
Tanning	0.1	1.5	2.9	1.0	0.9	-1.7
Hand grip strength (left)	2.1	5.6	8.0	1.8	-2.8	2.4
Number of treatments/medications taken	1.6	2.9	7.2	1.1	-2.7	-0.5
Average weekly spirits intake	0.4	0.5	1.2	0.4	-0.3	1.1
Sensitivity / hurt feelings	0.5	0.8	1.3	-0.2	-1.1	1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.0	0.8	-0.4	1.0
Hearing difficulty/problems: Yes	1.4	2.2	3.7	-1.9	-1.6	0.5
Relative age of first facial hair	0.3	0.7	1.0	1.0	-1.0	0.1
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	8.8	-0.0	-3.0	0.7
Ever used hormone-replacement therapy (HRT)	2.3	3.0	8.1	-0.1	0.9	-2.8
Ever had hysterectomy (womb removed)	3.5	4.0	5.3	-1.2	-2.3	-2.3
Systolic blood pressure, automated reading	0.4	1.1	1.4	0.9	-1.2	1.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.4	-0.3	-0.4
Angina	0.0	0.1	0.1	-0.2	0.2	0.3
Medication for hormone replacement therapy	1.1	1.3	1.7	-0.8	-1.3	-1.2
Vitamin and mineral supplements	2.7	3.6	8.8	-0.6	1.3	3.0
Supplements: Zinc	1.1	1.3	2.5	-0.8	0.8	-1.6
Medication: Co-codamol	0.8	0.9	1.5	1.2	0.6	0.9
Medication: Metformin	0.6	0.9	2.7	0.1	-1.6	0.1
Diabetes (father)	0.4	0.6	1.5	0.2	0.3	1.2
Diabetes (mother)	0.8	1.0	1.8	0.1	-1.4	1.0
Severe depression (siblings)	0.4	0.5	1.0	-0.0	0.6	-1.0
Pack years adult smoking proportion	1.5	2.2	4.8	-0.5	-2.2	1.2
Impedance of leg (right)	0.1	0.7	1.6	-1.3	-0.4	-0.5
Leg fat-free mass (left)	0.7	3.8	4.9	2.0	-2.2	1.6
Trunk fat percentage	0.2	0.8	1.8	-0.6	0.4	1.4
Hand grip strength (right)	1.9	5.0	7.8	1.4	-2.8	2.3
Townsend deprivation index at recruitment	1.9	2.7	5.8	1.3	-2.4	0.9
Current tobacco smoking	2.0	3.2	8.1	0.7	-2.9	1.0
Average weekly fortified wine intake	1.7	2.0	5.9	-0.2	2.4	0.4
Maternal smoking around birth	0.3	0.4	0.9	0.3	-0.9	0.6
Fed-up feelings	1.7	3.1	6.2	1.0	-2.5	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.3	-0.1	-0.7	1.2
Relative age voice broke	0.3	0.4	1.0	1.0	-0.4	-0.3
Taking other prescription medications	2.7	4.2	10.0	1.1	-3.2	-1.2
Age when periods started (menarche)	0.6	1.5	2.2	1.5	-1.4	-0.5
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.7	0.3	-2.2	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.6	0.2	-0.7	2.4
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.6	0.1	2.1	0.3
Qualifications: CSEs or equivalent	0.8	1.1	2.9	-0.6	-1.7	0.3
Serious illness, injury or assault to yourself	0.3	0.3	0.6	-0.5	0.8	-0.4
High blood pressure	0.3	0.9	1.8	-0.8	-1.4	-0.2
Hayfever, allergic rhinitis or eczema	1.7	3.7	5.4	1.8	2.3	-1.5
Multivitamins +/- minerals	2.0	2.6	4.0	0.4	-1.9	-2.0
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.1	-0.8	-0.2
Supplements: Glucosamine	0.2	0.3	0.8	-0.1	0.3	-0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.8	0.6	0.4	-1.3
Medication: Atenolol	0.1	0.1	0.4	-0.6	-0.2	0.2
Medication: Levothyroxine sodium	1.2	2.1	5.6	0.2	-2.4	0.7
Sitting height	0.2	1.1	3.4	-0.2	-0.0	-1.8
Chronic bronchitis/emphysema (father)	3.1	3.7	7.6	-1.8	-0.1	2.8
High blood pressure (mother)	1.1	1.6	3.3	-0.9	0.7	1.8
Body mass index (BMI)	0.2	0.9	2.1	0.7	0.5	1.4
Impedance of leg (left)	0.2	1.1	2.8	-1.7	-0.3	-0.6
Leg predicted mass (left)	0.7	3.8	4.8	2.0	-2.2	1.6
Trunk fat mass	0.2	0.8	1.8	0.2	-0.8	1.3
Waist circumference	0.9	3.1	4.2	1.3	-1.9	2.0
Number of incorrect matches in round	1.1	1.8	4.2	-0.3	-1.1	-2.0
Past tobacco smoking	0.7	1.3	3.1	-0.5	1.8	-0.7
Alcohol usually taken with meals	3.1	5.0	12.1	0.8	3.5	-1.5
Nervous feelings	0.5	0.9	1.7	0.6	-1.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.1	0.8	-1.4	0.5
Hearing difficulty/problems with background noise	0.4	0.6	1.9	-1.4	-0.1	0.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	-0.0	-0.4	1.3
Had menopause	0.9	1.1	3.1	-0.1	-0.3	-1.8
Had other major operations	3.4	4.1	9.4	0.7	-3.1	-1.6
Forced vital capacity (FVC)	0.2	0.9	2.2	1.5	0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	6.8	-0.1	-0.8	2.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.4	-0.1	0.7
Qualifications: None of the above	0.8	1.7	3.1	0.1	-1.8	-1.4
Financial difficulties in last 2 years	1.2	1.6	3.3	-1.2	-0.3	1.8
Mouth/teeth dental problems	0.4	0.6	0.8	-0.9	0.6	-0.8
Heart attack	0.6	0.7	2.2	0.0	-0.1	1.5
Allergy	1.3	3.0	4.9	-2.2	-1.8	1.0
Pain all over the body in last month	0.3	0.4	0.5	-0.6	-0.5	-0.7
Diabetes (self-reported)	0.5	0.7	1.3	0.6	-0.7	1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	1.3	0.7	-0.6
Medication: Ramipril	3.4	4.4	11.9	-1.1	-3.5	0.4
Medication: Simvastatin	1.1	1.6	4.5	-0.4	-2.1	-0.4
Fluid intelligence score	0.3	0.6	1.6	-0.5	1.3	0.4
Illnesses of siblings	0.2	0.2	0.7	0.0	0.8	-0.0
Neuroticism score	0.6	1.3	3.3	0.6	-1.8	-0.5
Weight	0.4	2.1	2.7	1.3	-1.6	1.4
Impedance of arm (right)	0.5	2.5	4.0	-1.8	2.0	-0.4
Arm fat percentage (right)	0.3	1.0	1.9	-0.4	0.9	1.4
Trunk fat-free mass	1.4	8.2	15.8	2.8	-4.0	1.0
Hip circumference	0.2	0.7	1.2	1.1	0.3	0.8
Time employed in main current job	3.1	3.6	10.4	-0.3	3.2	0.5
Alcohol intake versus 10 years previously	1.5	2.2	4.0	0.0	-2.0	1.6
Father’s age at death	1.4	1.9	5.3	2.3	0.5	-0.1
Worrier / anxious feelings	0.1	0.2	0.4	-0.2	0.3	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.6	-0.7	-1.6	-0.6
Falls in the last year	0.8	1.1	2.2	0.1	1.5	1.1
Hair/balding pattern: Pattern 3	0.6	0.9	2.7	-0.1	1.6	-0.3
Number of live births	0.4	0.5	0.9	-0.6	-0.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	2.4	1.1	1.5	-1.0
Pulse rate	0.8	1.3	2.6	-1.0	-0.6	-1.6
Happiness	1.7	2.0	5.4	2.3	-0.1	-0.8
Noisy workplace	1.5	1.8	5.3	0.3	-2.3	-0.3
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.5	-0.8	2.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.6	-1.3	0.5	0.5
Mouth/teeth dental problems: Dentures	1.3	2.2	3.1	-1.8	-1.5	1.2
Asthma	0.1	0.1	0.3	0.1	0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.8	-1.9	0.3	-0.3
Medication: Cholesterol lowering	0.9	1.4	2.9	-1.1	-1.7	0.3
Depression (self-reported)	0.9	1.1	2.6	0.6	1.6	-0.5
Medication: Lansoprazole	3.2	3.7	9.2	0.8	-3.0	1.1
Prospective memory result	1.1	1.3	2.0	-1.1	-1.4	-0.8
Lung cancer (father)	0.8	0.9	2.3	0.0	0.6	-1.5
Illnesses of mother	0.2	0.2	0.4	0.5	-0.6	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	1.7	1.0	0.9	-1.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	-0.0	-0.5	-0.8
Impedance of arm (left)	0.6	2.6	4.7	-1.7	2.2	-0.3
Arm fat mass (right)	0.1	0.4	0.9	0.5	0.1	0.9
Trunk predicted mass	1.5	8.5	16.3	2.8	-4.0	1.0
Standing height	0.8	7.8	21.3	1.5	-4.6	-0.1
Length of working week for main job	0.4	0.4	1.0	1.0	0.2	-0.5
Exposure to tobacco smoke at home	1.0	1.1	1.5	-0.9	-1.1	1.2
Breastfed as a baby	1.5	1.8	3.6	-1.3	0.3	-1.9
Tense / ‘highly strung’	2.4	4.0	7.1	-0.0	-2.2	-2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.1	1.1	-0.6	-1.8
Hair/balding pattern: Pattern 4	1.3	3.2	7.8	1.0	2.8	-0.9
Birth weight of first child	0.0	0.0	0.1	-0.2	0.2	-0.2
Peak expiratory flow (PEF)	0.4	1.0	2.4	-0.0	1.6	-0.7
Pulse wave reflection index	0.6	0.7	1.9	1.4	0.3	-0.4
Ever highly irritable/argumentative for 2 days	2.0	2.3	4.7	1.5	0.3	2.2
Loud music exposure frequency	0.7	0.8	1.3	1.0	-0.1	-1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.9	0.3	2.0	1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	0.7	1.6	-0.9
Blood clot in the leg (DVT)	0.6	0.8	1.6	0.9	0.4	-1.3
Medication: Paracetamol	1.4	2.3	3.2	0.9	-1.8	1.7
Headache pain in last month	0.1	0.2	0.3	-0.2	0.5	-0.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.3	0.5	2.1	0.6
Glaucoma (self-reported)	0.0	0.0	0.1	-0.2	-0.3	0.1
Gout (self-reported)	3.5	4.8	11.1	-1.8	3.3	0.4
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	5.0	-0.3	-2.2	1.7
Medication: Amlodipine	0.2	0.3	0.7	0.4	-0.8	-0.0
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.4	1.8	0.7	0.8
Birth weight	0.7	1.5	3.3	0.8	-0.7	-1.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.4	0.7	-0.8	1.2
High blood pressure (siblings)	0.0	0.0	0.1	0.1	0.3	0.1
Forced vital capacity (FVC), Best measure	0.2	0.9	1.8	1.4	0.4	-0.8
Body fat percentage	0.2	0.7	1.7	-0.6	0.2	1.3
Leg fat percentage (right)	0.1	0.4	1.1	-0.1	-0.4	1.0
Arm fat-free mass (right)	1.6	8.2	17.9	2.4	-4.2	1.1
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.4	-1.0	0.0
Comparative body size at age 10	0.1	0.4	1.0	-0.4	1.0	-0.1
Number of full brothers	0.9	1.1	1.7	1.3	-0.9	0.9
Worry too long after embarrassment	1.9	3.1	5.8	1.4	-2.4	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	6.8	1.1	-2.6	0.2
Wheeze or whistling in the chest in last year	2.7	4.8	11.5	0.7	-1.5	3.4
Number of children fathered	0.5	0.6	1.3	0.7	-0.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.9	-0.2	0.9	0.5
Age at first live birth	1.3	2.2	6.6	0.1	2.6	0.3
Pulse wave peak to peak time	0.2	0.3	0.8	0.1	0.1	0.9
Health satisfaction	0.7	0.9	1.2	1.1	-1.0	-0.6
Shortness of breath walking on level ground	1.2	1.4	4.1	2.0	-0.4	0.2
Qualifications: College or University degree	1.6	5.1	14.5	0.8	3.8	0.3
Eye problems/disorders: None of the above	0.7	0.8	1.9	1.4	-0.4	0.7
Mouth/teeth dental problems: Loose teeth	1.9	2.3	5.7	2.4	-0.9	0.5
Emphysema/chronic bronchitis	0.3	0.4	0.6	-0.5	0.8	0.5
Medication for pain relief, constipation, heartburn	0.7	1.2	2.7	-0.0	1.6	-0.9
Neck or shoulder pain in last month	0.6	0.8	1.4	0.3	-1.2	-0.9
Medication: Blood pressure	0.7	1.2	3.1	-0.3	-1.8	-0.6
Angina (self-reported)	0.1	0.1	0.2	-0.2	0.2	0.5
Migraine (self-reported)	1.8	2.3	3.9	0.7	-2.0	-1.5
Medication: Ibuprofen	1.0	1.2	3.5	-1.9	0.0	-0.0
Medication: Allopurinol	0.3	0.4	0.6	-0.8	0.8	-0.3
Medication: Omeprazole	0.1	0.1	0.1	0.3	0.4	0.1
Medication: Seretide 50 evohaler	0.7	0.8	2.5	0.1	-0.2	1.6
Mean time to correctly identify matches	2.3	4.5	11.6	1.0	-0.9	-3.4
Heart disease (mother)	0.9	1.1	2.2	-1.1	0.1	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-0.1	-1.1	-0.9
Whole body fat mass	0.2	0.8	1.6	0.1	-0.9	1.3
Leg fat mass (right)	0.3	1.0	1.7	0.4	-1.3	1.0
Arm predicted mass (right)	1.6	8.1	16.2	2.5	-4.0	1.4
Pulse rate, automated reading	0.3	1.1	2.7	-0.8	-0.2	-1.6
Alcohol intake frequency.	1.9	4.4	12.3	0.8	-3.5	-0.6
Comparative height size at age 10	0.8	4.3	12.2	0.8	-3.5	0.2
Number of full sisters	2.1	2.5	5.9	0.3	-2.4	1.3
Suffer from ‘nerves’	0.3	0.5	0.7	0.8	-0.9	0.1
Overall health rating	1.5	3.3	6.5	1.6	-2.5	0.9
Chest pain or discomfort	0.1	0.1	0.3	-0.2	-0.6	0.2
Had major operations	0.6	0.7	1.3	-0.6	-0.6	1.1
Age at last live birth	0.5	0.7	1.9	-0.1	1.4	-0.5
Family relationship satisfaction	3.6	4.4	6.9	2.2	1.1	-2.6
Leg pain on walking	1.2	1.5	2.9	1.0	-0.9	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	2.2	-1.5	-1.4	-1.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	-0.4	1.2	0.3
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	5.4	2.3	-0.2	-0.5
Medication: Aspirin	0.8	1.1	3.3	0.0	-1.8	-0.3
Supplements: Vitamin C	0.7	0.8	2.1	-0.4	-0.4	-1.4
Knee pain experienced in last month	1.0	1.6	3.1	0.2	-1.8	1.3
Hypertension (Self-reported)	0.4	1.2	3.3	-0.6	-1.8	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	5.9	1.2	-2.4	-0.1
Illnesses of father: Heart disease	0.7	1.0	1.6	1.0	0.6	-1.3
Illnesses of siblings: Diabetes	2.7	3.4	6.6	-0.5	-2.6	1.8
Smoking status: Previous	0.4	0.6	1.4	0.5	-1.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	0.3	-0.7	0.0
Whole body fat-free mass	1.2	6.7	12.2	2.5	-3.5	1.2
Leg fat-free mass (right)	0.6	3.3	3.9	1.9	-2.0	1.5
Arm fat percentage (left)	0.2	1.0	2.0	-0.3	0.9	1.4
Average weekly red wine intake	2.0	2.9	6.8	0.7	2.6	-1.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.1	-0.5	0.1	-1.5
Mood swings	0.8	1.4	2.8	0.9	-1.7	-0.9
Loneliness, isolation	0.2	0.3	0.7	0.1	-0.8	-0.4
Long-standing illness, disability or infirmity	2.5	3.8	10.1	-0.5	-3.2	1.0
Ever had bowel cancer screening	0.2	0.2	0.7	0.0	0.1	-0.9
Diabetes diagnosed by doctor	0.4	0.7	1.5	0.5	-1.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.7	-1.1	-0.6	1.6
Friendships satisfaction	0.9	1.1	2.7	1.7	0.4	-0.7
Qualifications: nursing, teaching	2.4	3.8	9.7	0.6	3.1	1.2
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.2	0.3	0.4
Eye problems/disorders: Cataract	0.6	0.7	1.6	-1.3	0.6	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	0.7	-0.4	1.5
Medication for cholesterol	1.3	2.0	3.3	0.3	1.6	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.0	-1.7	-0.4	-0.9
Back pain experienced in last month	0.7	1.1	2.0	0.6	-1.4	1.0
Mineral and other dietary supplements	0.5	0.7	1.2	0.0	0.9	1.1
Breast cancer (self-reported)	0.6	0.7	1.6	-0.0	0.8	-1.3
Asthma (self-reported)	0.1	0.1	0.3	-0.2	0.6	-0.2
Osteoporosis (self-reported)	0.4	0.5	1.5	-1.2	0.3	0.2
Osteoarthritis (self-reported)	0.4	0.5	1.4	-0.4	-1.2	0.1
Medication: Aspirin	0.7	1.0	2.7	0.3	-1.6	-0.4
Medication: Gliclazide	0.2	0.2	0.5	0.7	0.1	0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.5	-0.2	0.3
Smoking status: Current	1.3	2.1	5.2	0.7	-2.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	10.8	-0.0	1.5	-3.3
Whole body water mass	1.2	6.6	11.8	2.6	-3.4	1.2
Leg predicted mass (right)	0.6	3.5	4.0	2.0	-2.0	1.6
Arm fat mass (left)	0.1	0.6	1.5	0.5	-0.3	1.2
Number of self-reported non-cancer illnesses	1.6	2.8	8.2	0.6	-2.9	0.1
Average weekly champagne plus white wine intake	1.9	2.6	7.6	0.1	2.8	0.2
Miserableness	0.0	0.1	0.2	-0.4	-0.1	0.2
Guilty feelings	1.0	1.5	2.4	1.6	-1.4	0.4
Wears glasses or contact lenses	1.7	1.9	3.0	1.5	-1.7	0.6
Ever taken oral contraceptive pill	1.4	1.5	2.8	1.7	-1.2	-0.6
Hearing aid user	0.6	0.7	1.7	-0.4	-1.3	-0.5
Mother’s age at death	0.6	0.7	1.1	1.1	-1.0	0.3
Financial situation satisfaction	0.2	0.3	0.6	0.8	0.5	-0.1
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.5	-1.6	-0.8	-1.1
Commuting to job workplace: Public transport	1.4	1.6	3.3	0.3	-1.2	-1.8
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.1	-0.3	-0.1
Medication: Blood pressure	0.1	0.2	0.3	-0.4	-0.3	-0.6
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.0	-0.5	-0.6	2.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.1	-0.1	-1.4	-1.8
High cholesterol (Self-reported)	0.7	1.2	2.0	-1.4	-1.2	-0.2
Medication: Bendroflumethiazide	0.4	0.6	1.7	1.3	0.4	-0.3
Medication: Paracetamol	1.2	1.9	2.6	1.0	-1.6	1.5
Medication: Lisinopril	0.4	0.5	1.4	-1.2	0.2	-0.4
Medication: Atorvastatin	3.4	4.2	8.0	0.1	-2.8	2.2
Illnesses of father: High blood pressure	0.2	0.3	0.4	0.6	-0.2	0.6
Alcohol drinker status: Never	1.2	1.5	3.8	0.6	-1.9	-0.5
Ever smoked	0.5	0.8	1.2	-0.4	-1.1	1.1
Basal metabolic rate	1.0	5.5	9.4	2.3	-3.1	1.4
Leg fat percentage (left)	0.2	0.6	1.6	-0.2	-0.3	1.3
Arm fat-free mass (left)	1.4	7.0	14.4	2.3	-3.8	1.1
Number of operations (self-reported)	1.8	2.6	4.1	0.1	-2.0	-1.9
Average weekly beer plus cider intake	1.9	2.7	6.9	-0.8	-2.6	0.8
Irritability	0.7	1.2	1.8	1.3	-1.4	0.0
Risk taking	0.4	0.6	1.5	-0.2	-1.2	0.5
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.2	-0.1	-1.0	-1.8
Fractured/broken bones in last 5 years	1.3	1.7	5.2	-0.0	0.2	2.3
Age started oral contraceptive pill	0.6	0.7	1.0	0.9	-0.5	-1.0
Diastolic blood pressure, automated reading	0.5	1.5	4.1	2.0	0.5	-0.1
Ever depressed for a whole week	1.6	1.9	4.0	2.0	0.7	1.1
Unable to work because of sickness or disability	1.2	1.6	2.5	0.5	-1.6	1.4
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.3	-0.8	0.3
Myopia	0.1	0.1	0.2	0.2	-0.1	-0.5
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.2	1.1	1.5	-0.3
Cholesterol lowering medication	1.8	2.6	5.8	0.6	-2.4	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.6	0.0	-0.5
Pain experienced in last month	0.5	0.8	2.3	0.1	1.5	0.3
Supplements: Calcium	0.8	0.9	2.5	-1.6	0.2	0.5
Basal cell carcinoma (self-reported)	0.5	0.7	1.0	-0.6	1.0	-0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	0.1	-0.3	1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.0	0.1	0.3	-1.4
Heart disease (siblings)	0.4	0.5	0.7	0.6	-0.8	-0.5
Alcohol drinker status: Previous	2.8	3.2	6.0	1.9	-2.4	-0.4
Pack years of smoking	1.0	1.4	3.7	-0.4	-1.9	0.6
Impedance of whole body	0.4	2.0	4.4	-2.1	1.2	-0.5
Leg fat mass (left)	0.3	1.0	1.6	0.3	-1.3	1.2
Arm predicted mass (left)	1.4	6.9	13.8	2.3	-3.7	1.3