Hub : Genes

ZNF460

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0660 0.0250 2.5e-03 0.017 0.015 0.004 0.018 0.006 2.8e-03 5.8e-03 0.10000 2.6e-03 5.7e-02
2 NTR Blood 0.0423 0.0137 3.3e-05 0.024 0.016 0.011 0.022 0.019 1.7e-08 5.5e-06 0.00014 9.5e-08 7.8e-07
3 TCGA Thyroid Carcinoma 0.0450 0.0200 9.6e-04 0.040 0.017 0.030 NA 0.000 9.2e-05 7.7e-03 0.00055 NA 3.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.4 2.7 1.6 1.1 -0.5
Bipolar Disorder or Schizophrenia 0.9 2.1 3.8 2.0 1.4 -0.6
Depressed Affect (Nagel 2018) 0.1 0.1 0.3 -0.1 -0.6 -0.1
Depression (Nagel 2018) 0.2 0.2 0.4 0.6 0.1 0.6
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.1 -0.1 0.4 1.0
Neuroticism (Nagel 2018) 0.3 0.6 1.3 0.2 -1.1 0.8
Schizophrenia (2018) 0.4 0.8 1.4 1.2 0.9 -0.3
Schizophrenia vs Biploar Disorder 0.4 0.6 1.6 -0.3 1.2 0.3
Worry (Nagel 2018) 0.1 0.2 0.3 -0.2 -0.5 -0.5
Alzheimer’s Disease (in mother) 1.1 1.3 2.2 -0.4 1.3 -1.5
Alzheimer’s Disease (in father) 0.8 0.8 2.2 1.5 -0.1 -0.6
Alzheimer’s Disease (including proxy) 0.8 1.2 2.7 0.7 0.6 -1.6
Crohns Disease (2017) 1.5 3.4 10.2 0.1 3.2 0.1
Irritable Bowel Disease (IBD) 1.1 2.6 7.5 -0.2 2.7 -0.5
Ulcerative Colitis (UC) 0.9 1.7 3.2 -0.6 1.8 -1.2
Major Depression (MDD) 1.9 2.3 5.8 -0.2 2.4 1.0
Reaction Time 1.9 3.6 10.2 0.4 0.7 -3.2
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.3 -0.2 0.6 0.5
Breast Cancer 0.9 2.2 2.8 -1.7 1.2 1.5
Ovarian Cancer 2.6 3.4 7.2 -0.6 1.6 2.7
Prostate Cancer 0.5 0.8 1.1 0.2 -1.1 1.1
Age at First Birth 0.2 0.3 0.5 -0.2 -0.6 0.7
Bipolar Disorder (2011) 1.1 1.0 1.9 1.4 1.1 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 1.0 0.7 0.6 -1.0
Coronary Artery Disease (CAD) 1.7 2.0 4.9 -1.0 2.2 0.3
Crohns Disease (2012) 2.7 4.4 12.8 -0.5 3.6 -0.1
Mean Putamen Volume 0.1 0.1 0.3 -0.3 0.1 0.6
Fasting Glucose 1.4 1.7 3.3 -1.8 -1.4 0.3
HbA1C 0.5 0.5 1.5 -1.2 0.3 0.1
HDL Cholesterol 0.2 0.4 0.8 -0.9 0.0 0.7
LDL Cholesterol 1.0 1.7 3.5 0.4 -1.9 -1.1
Lupus 0.4 0.6 1.3 1.1 0.4 -0.5
Neuroticism (2016) 0.1 0.1 0.1 0.4 -0.4 0.1
Primary Biliary Cirrhosis 0.3 0.4 1.1 -1.0 0.3 0.5
Rheumatoid Arthritis 1.7 2.3 6.0 -2.5 1.0 0.2
Schizophrenia (2014) 0.5 1.0 1.6 1.2 1.2 -0.4
Triglycerides 0.4 0.7 1.2 0.2 -1.1 -0.9
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.5 1.6 -0.1 0.2
Ulcerative Colitis 0.7 1.0 1.5 -0.2 1.2 -1.2
Blood Eosinophil Count 0.7 5.7 8.2 -1.3 2.7 2.9
Blood Platelet Count 0.5 6.2 9.2 -2.1 3.0 -2.2
Blood Red Count 0.1 1.0 2.6 1.6 0.2 -0.5
Blood White Count 0.2 1.4 3.7 -0.1 -0.6 1.9
Heel T-Score 1.1 9.0 14.5 0.1 -3.8 3.5
BMI 0.4 2.1 4.0 0.6 1.4 2.0
Height 0.9 16.6 46.2 1.2 -6.8 1.4
Waist Hip Ratio (WHR) 1.2 5.5 8.6 -0.2 -2.9 2.8
Systolic Blood Pressure 0.4 2.2 5.3 1.1 -2.3 0.3
Smoking Status 1.6 3.9 10.3 0.8 -3.2 0.9
Allergy or Eczema 1.4 3.6 7.0 0.1 2.6 -2.0
Cardiovascular Disease 0.2 0.6 1.7 -0.0 -1.3 -0.2
Hypothyroidism (self reported) 1.2 2.7 7.7 0.1 -2.8 0.6
Respiratory disease 0.7 1.5 2.4 -1.6 1.4 -0.0
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.5 0.9 -1.6 0.7
Lung FEV1/FVC ratio 0.5 2.5 3.7 -1.3 1.4 -1.9
Lung FVC 0.6 3.1 7.3 0.3 2.7 -1.4
Neuroticism 0.4 0.9 2.5 -0.1 -1.6 0.4
Chronotype (morning person) 0.3 0.6 1.6 -1.3 0.4 -0.3
Hair Pigment 0.0 0.6 1.3 -1.2 -0.6 -0.4
Tanning 0.1 1.5 2.9 1.0 0.9 -1.7
Hand grip strength (left) 2.1 5.6 8.0 1.8 -2.8 2.4
Number of treatments/medications taken 1.6 2.9 7.2 1.1 -2.7 -0.5
Average weekly spirits intake 0.4 0.5 1.2 0.4 -0.3 1.1
Sensitivity / hurt feelings 0.5 0.8 1.3 -0.2 -1.1 1.0
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.0 0.8 -0.4 1.0
Hearing difficulty/problems: Yes 1.4 2.2 3.7 -1.9 -1.6 0.5
Relative age of first facial hair 0.3 0.7 1.0 1.0 -1.0 0.1
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 8.8 -0.0 -3.0 0.7
Ever used hormone-replacement therapy (HRT) 2.3 3.0 8.1 -0.1 0.9 -2.8
Ever had hysterectomy (womb removed) 3.5 4.0 5.3 -1.2 -2.3 -2.3
Systolic blood pressure, automated reading 0.4 1.1 1.4 0.9 -1.2 1.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 0.4 -0.3 -0.4
Angina 0.0 0.1 0.1 -0.2 0.2 0.3
Medication for hormone replacement therapy 1.1 1.3 1.7 -0.8 -1.3 -1.2
Vitamin and mineral supplements 2.7 3.6 8.8 -0.6 1.3 3.0
Supplements: Zinc 1.1 1.3 2.5 -0.8 0.8 -1.6
Medication: Co-codamol 0.8 0.9 1.5 1.2 0.6 0.9
Medication: Metformin 0.6 0.9 2.7 0.1 -1.6 0.1
Diabetes (father) 0.4 0.6 1.5 0.2 0.3 1.2
Diabetes (mother) 0.8 1.0 1.8 0.1 -1.4 1.0
Severe depression (siblings) 0.4 0.5 1.0 -0.0 0.6 -1.0
Pack years adult smoking proportion 1.5 2.2 4.8 -0.5 -2.2 1.2
Impedance of leg (right) 0.1 0.7 1.6 -1.3 -0.4 -0.5
Leg fat-free mass (left) 0.7 3.8 4.9 2.0 -2.2 1.6
Trunk fat percentage 0.2 0.8 1.8 -0.6 0.4 1.4
Hand grip strength (right) 1.9 5.0 7.8 1.4 -2.8 2.3
Townsend deprivation index at recruitment 1.9 2.7 5.8 1.3 -2.4 0.9
Current tobacco smoking 2.0 3.2 8.1 0.7 -2.9 1.0
Average weekly fortified wine intake 1.7 2.0 5.9 -0.2 2.4 0.4
Maternal smoking around birth 0.3 0.4 0.9 0.3 -0.9 0.6
Fed-up feelings 1.7 3.1 6.2 1.0 -2.5 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.3 -0.1 -0.7 1.2
Relative age voice broke 0.3 0.4 1.0 1.0 -0.4 -0.3
Taking other prescription medications 2.7 4.2 10.0 1.1 -3.2 -1.2
Age when periods started (menarche) 0.6 1.5 2.2 1.5 -1.4 -0.5
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 4.7 0.3 -2.2 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 5.6 0.2 -0.7 2.4
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 4.6 0.1 2.1 0.3
Qualifications: CSEs or equivalent 0.8 1.1 2.9 -0.6 -1.7 0.3
Serious illness, injury or assault to yourself 0.3 0.3 0.6 -0.5 0.8 -0.4
High blood pressure 0.3 0.9 1.8 -0.8 -1.4 -0.2
Hayfever, allergic rhinitis or eczema 1.7 3.7 5.4 1.8 2.3 -1.5
Multivitamins +/- minerals 2.0 2.6 4.0 0.4 -1.9 -2.0
Stomach or abdominal pain in last month 0.2 0.2 0.6 -0.1 -0.8 -0.2
Supplements: Glucosamine 0.2 0.3 0.8 -0.1 0.3 -0.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.8 0.6 0.4 -1.3
Medication: Atenolol 0.1 0.1 0.4 -0.6 -0.2 0.2
Medication: Levothyroxine sodium 1.2 2.1 5.6 0.2 -2.4 0.7
Sitting height 0.2 1.1 3.4 -0.2 -0.0 -1.8
Chronic bronchitis/emphysema (father) 3.1 3.7 7.6 -1.8 -0.1 2.8
High blood pressure (mother) 1.1 1.6 3.3 -0.9 0.7 1.8
Body mass index (BMI) 0.2 0.9 2.1 0.7 0.5 1.4
Impedance of leg (left) 0.2 1.1 2.8 -1.7 -0.3 -0.6
Leg predicted mass (left) 0.7 3.8 4.8 2.0 -2.2 1.6
Trunk fat mass 0.2 0.8 1.8 0.2 -0.8 1.3
Waist circumference 0.9 3.1 4.2 1.3 -1.9 2.0
Number of incorrect matches in round 1.1 1.8 4.2 -0.3 -1.1 -2.0
Past tobacco smoking 0.7 1.3 3.1 -0.5 1.8 -0.7
Alcohol usually taken with meals 3.1 5.0 12.1 0.8 3.5 -1.5
Nervous feelings 0.5 0.9 1.7 0.6 -1.3 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.1 0.8 -1.4 0.5
Hearing difficulty/problems with background noise 0.4 0.6 1.9 -1.4 -0.1 0.1
Hair/balding pattern: Pattern 2 0.5 0.6 1.6 -0.0 -0.4 1.3
Had menopause 0.9 1.1 3.1 -0.1 -0.3 -1.8
Had other major operations 3.4 4.1 9.4 0.7 -3.1 -1.6
Forced vital capacity (FVC) 0.2 0.9 2.2 1.5 0.2 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 6.8 -0.1 -0.8 2.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.4 0.4 -0.1 0.7
Qualifications: None of the above 0.8 1.7 3.1 0.1 -1.8 -1.4
Financial difficulties in last 2 years 1.2 1.6 3.3 -1.2 -0.3 1.8
Mouth/teeth dental problems 0.4 0.6 0.8 -0.9 0.6 -0.8
Heart attack 0.6 0.7 2.2 0.0 -0.1 1.5
Allergy 1.3 3.0 4.9 -2.2 -1.8 1.0
Pain all over the body in last month 0.3 0.4 0.5 -0.6 -0.5 -0.7
Diabetes (self-reported) 0.5 0.7 1.3 0.6 -0.7 1.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.6 1.3 0.7 -0.6
Medication: Ramipril 3.4 4.4 11.9 -1.1 -3.5 0.4
Medication: Simvastatin 1.1 1.6 4.5 -0.4 -2.1 -0.4
Fluid intelligence score 0.3 0.6 1.6 -0.5 1.3 0.4
Illnesses of siblings 0.2 0.2 0.7 0.0 0.8 -0.0
Neuroticism score 0.6 1.3 3.3 0.6 -1.8 -0.5
Weight 0.4 2.1 2.7 1.3 -1.6 1.4
Impedance of arm (right) 0.5 2.5 4.0 -1.8 2.0 -0.4
Arm fat percentage (right) 0.3 1.0 1.9 -0.4 0.9 1.4
Trunk fat-free mass 1.4 8.2 15.8 2.8 -4.0 1.0
Hip circumference 0.2 0.7 1.2 1.1 0.3 0.8
Time employed in main current job 3.1 3.6 10.4 -0.3 3.2 0.5
Alcohol intake versus 10 years previously 1.5 2.2 4.0 0.0 -2.0 1.6
Father’s age at death 1.4 1.9 5.3 2.3 0.5 -0.1
Worrier / anxious feelings 0.1 0.2 0.4 -0.2 0.3 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.6 -0.7 -1.6 -0.6
Falls in the last year 0.8 1.1 2.2 0.1 1.5 1.1
Hair/balding pattern: Pattern 3 0.6 0.9 2.7 -0.1 1.6 -0.3
Number of live births 0.4 0.5 0.9 -0.6 -0.9 0.5
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 2.4 1.1 1.5 -1.0
Pulse rate 0.8 1.3 2.6 -1.0 -0.6 -1.6
Happiness 1.7 2.0 5.4 2.3 -0.1 -0.8
Noisy workplace 1.5 1.8 5.3 0.3 -2.3 -0.3
Qualifications: A levels/AS levels or equivalent 0.8 1.7 4.5 -0.8 2.1 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.6 -1.3 0.5 0.5
Mouth/teeth dental problems: Dentures 1.3 2.2 3.1 -1.8 -1.5 1.2
Asthma 0.1 0.1 0.3 0.1 0.5 0.1
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.8 -1.9 0.3 -0.3
Medication: Cholesterol lowering 0.9 1.4 2.9 -1.1 -1.7 0.3
Depression (self-reported) 0.9 1.1 2.6 0.6 1.6 -0.5
Medication: Lansoprazole 3.2 3.7 9.2 0.8 -3.0 1.1
Prospective memory result 1.1 1.3 2.0 -1.1 -1.4 -0.8
Lung cancer (father) 0.8 0.9 2.3 0.0 0.6 -1.5
Illnesses of mother 0.2 0.2 0.4 0.5 -0.6 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 1.7 1.0 0.9 -1.3
Pulse wave Arterial Stiffness index 0.3 0.3 0.7 -0.0 -0.5 -0.8
Impedance of arm (left) 0.6 2.6 4.7 -1.7 2.2 -0.3
Arm fat mass (right) 0.1 0.4 0.9 0.5 0.1 0.9
Trunk predicted mass 1.5 8.5 16.3 2.8 -4.0 1.0
Standing height 0.8 7.8 21.3 1.5 -4.6 -0.1
Length of working week for main job 0.4 0.4 1.0 1.0 0.2 -0.5
Exposure to tobacco smoke at home 1.0 1.1 1.5 -0.9 -1.1 1.2
Breastfed as a baby 1.5 1.8 3.6 -1.3 0.3 -1.9
Tense / ‘highly strung’ 2.4 4.0 7.1 -0.0 -2.2 -2.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.1 1.1 -0.6 -1.8
Hair/balding pattern: Pattern 4 1.3 3.2 7.8 1.0 2.8 -0.9
Birth weight of first child 0.0 0.0 0.1 -0.2 0.2 -0.2
Peak expiratory flow (PEF) 0.4 1.0 2.4 -0.0 1.6 -0.7
Pulse wave reflection index 0.6 0.7 1.9 1.4 0.3 -0.4
Ever highly irritable/argumentative for 2 days 2.0 2.3 4.7 1.5 0.3 2.2
Loud music exposure frequency 0.7 0.8 1.3 1.0 -0.1 -1.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 3.9 0.3 2.0 1.0
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.6 0.7 1.6 -0.9
Blood clot in the leg (DVT) 0.6 0.8 1.6 0.9 0.4 -1.3
Medication: Paracetamol 1.4 2.3 3.2 0.9 -1.8 1.7
Headache pain in last month 0.1 0.2 0.3 -0.2 0.5 -0.6
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.3 0.5 2.1 0.6
Glaucoma (self-reported) 0.0 0.0 0.1 -0.2 -0.3 0.1
Gout (self-reported) 3.5 4.8 11.1 -1.8 3.3 0.4
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 5.0 -0.3 -2.2 1.7
Medication: Amlodipine 0.2 0.3 0.7 0.4 -0.8 -0.0
Medication: Ventolin 100micrograms inhaler 1.2 1.5 3.4 1.8 0.7 0.8
Birth weight 0.7 1.5 3.3 0.8 -0.7 -1.8
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.4 0.7 -0.8 1.2
High blood pressure (siblings) 0.0 0.0 0.1 0.1 0.3 0.1
Forced vital capacity (FVC), Best measure 0.2 0.9 1.8 1.4 0.4 -0.8
Body fat percentage 0.2 0.7 1.7 -0.6 0.2 1.3
Leg fat percentage (right) 0.1 0.4 1.1 -0.1 -0.4 1.0
Arm fat-free mass (right) 1.6 8.2 17.9 2.4 -4.2 1.1
Exposure to tobacco smoke outside home 0.3 0.4 0.9 0.4 -1.0 0.0
Comparative body size at age 10 0.1 0.4 1.0 -0.4 1.0 -0.1
Number of full brothers 0.9 1.1 1.7 1.3 -0.9 0.9
Worry too long after embarrassment 1.9 3.1 5.8 1.4 -2.4 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 6.8 1.1 -2.6 0.2
Wheeze or whistling in the chest in last year 2.7 4.8 11.5 0.7 -1.5 3.4
Number of children fathered 0.5 0.6 1.3 0.7 -0.3 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.9 -0.2 0.9 0.5
Age at first live birth 1.3 2.2 6.6 0.1 2.6 0.3
Pulse wave peak to peak time 0.2 0.3 0.8 0.1 0.1 0.9
Health satisfaction 0.7 0.9 1.2 1.1 -1.0 -0.6
Shortness of breath walking on level ground 1.2 1.4 4.1 2.0 -0.4 0.2
Qualifications: College or University degree 1.6 5.1 14.5 0.8 3.8 0.3
Eye problems/disorders: None of the above 0.7 0.8 1.9 1.4 -0.4 0.7
Mouth/teeth dental problems: Loose teeth 1.9 2.3 5.7 2.4 -0.9 0.5
Emphysema/chronic bronchitis 0.3 0.4 0.6 -0.5 0.8 0.5
Medication for pain relief, constipation, heartburn 0.7 1.2 2.7 -0.0 1.6 -0.9
Neck or shoulder pain in last month 0.6 0.8 1.4 0.3 -1.2 -0.9
Medication: Blood pressure 0.7 1.2 3.1 -0.3 -1.8 -0.6
Angina (self-reported) 0.1 0.1 0.2 -0.2 0.2 0.5
Migraine (self-reported) 1.8 2.3 3.9 0.7 -2.0 -1.5
Medication: Ibuprofen 1.0 1.2 3.5 -1.9 0.0 -0.0
Medication: Allopurinol 0.3 0.4 0.6 -0.8 0.8 -0.3
Medication: Omeprazole 0.1 0.1 0.1 0.3 0.4 0.1
Medication: Seretide 50 evohaler 0.7 0.8 2.5 0.1 -0.2 1.6
Mean time to correctly identify matches 2.3 4.5 11.6 1.0 -0.9 -3.4
Heart disease (mother) 0.9 1.1 2.2 -1.1 0.1 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.3 -0.1 -1.1 -0.9
Whole body fat mass 0.2 0.8 1.6 0.1 -0.9 1.3
Leg fat mass (right) 0.3 1.0 1.7 0.4 -1.3 1.0
Arm predicted mass (right) 1.6 8.1 16.2 2.5 -4.0 1.4
Pulse rate, automated reading 0.3 1.1 2.7 -0.8 -0.2 -1.6
Alcohol intake frequency. 1.9 4.4 12.3 0.8 -3.5 -0.6
Comparative height size at age 10 0.8 4.3 12.2 0.8 -3.5 0.2
Number of full sisters 2.1 2.5 5.9 0.3 -2.4 1.3
Suffer from ‘nerves’ 0.3 0.5 0.7 0.8 -0.9 0.1
Overall health rating 1.5 3.3 6.5 1.6 -2.5 0.9
Chest pain or discomfort 0.1 0.1 0.3 -0.2 -0.6 0.2
Had major operations 0.6 0.7 1.3 -0.6 -0.6 1.1
Age at last live birth 0.5 0.7 1.9 -0.1 1.4 -0.5
Family relationship satisfaction 3.6 4.4 6.9 2.2 1.1 -2.6
Leg pain on walking 1.2 1.5 2.9 1.0 -0.9 1.7
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 2.2 -1.5 -1.4 -1.3
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.4 -0.4 1.2 0.3
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 5.4 2.3 -0.2 -0.5
Medication: Aspirin 0.8 1.1 3.3 0.0 -1.8 -0.3
Supplements: Vitamin C 0.7 0.8 2.1 -0.4 -0.4 -1.4
Knee pain experienced in last month 1.0 1.6 3.1 0.2 -1.8 1.3
Hypertension (Self-reported) 0.4 1.2 3.3 -0.6 -1.8 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.4 5.9 1.2 -2.4 -0.1
Illnesses of father: Heart disease 0.7 1.0 1.6 1.0 0.6 -1.3
Illnesses of siblings: Diabetes 2.7 3.4 6.6 -0.5 -2.6 1.8
Smoking status: Previous 0.4 0.6 1.4 0.5 -1.2 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 0.3 -0.7 0.0
Whole body fat-free mass 1.2 6.7 12.2 2.5 -3.5 1.2
Leg fat-free mass (right) 0.6 3.3 3.9 1.9 -2.0 1.5
Arm fat percentage (left) 0.2 1.0 2.0 -0.3 0.9 1.4
Average weekly red wine intake 2.0 2.9 6.8 0.7 2.6 -1.2
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.1 -0.5 0.1 -1.5
Mood swings 0.8 1.4 2.8 0.9 -1.7 -0.9
Loneliness, isolation 0.2 0.3 0.7 0.1 -0.8 -0.4
Long-standing illness, disability or infirmity 2.5 3.8 10.1 -0.5 -3.2 1.0
Ever had bowel cancer screening 0.2 0.2 0.7 0.0 0.1 -0.9
Diabetes diagnosed by doctor 0.4 0.7 1.5 0.5 -1.2 0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.7 -1.1 -0.6 1.6
Friendships satisfaction 0.9 1.1 2.7 1.7 0.4 -0.7
Qualifications: nursing, teaching 2.4 3.8 9.7 0.6 3.1 1.2
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.2 0.3 0.4
Eye problems/disorders: Cataract 0.6 0.7 1.6 -1.3 0.6 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.4 0.7 -0.4 1.5
Medication for cholesterol 1.3 2.0 3.3 0.3 1.6 1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.0 -1.7 -0.4 -0.9
Back pain experienced in last month 0.7 1.1 2.0 0.6 -1.4 1.0
Mineral and other dietary supplements 0.5 0.7 1.2 0.0 0.9 1.1
Breast cancer (self-reported) 0.6 0.7 1.6 -0.0 0.8 -1.3
Asthma (self-reported) 0.1 0.1 0.3 -0.2 0.6 -0.2
Osteoporosis (self-reported) 0.4 0.5 1.5 -1.2 0.3 0.2
Osteoarthritis (self-reported) 0.4 0.5 1.4 -0.4 -1.2 0.1
Medication: Aspirin 0.7 1.0 2.7 0.3 -1.6 -0.4
Medication: Gliclazide 0.2 0.2 0.5 0.7 0.1 0.0
Illnesses of father: None of the above (group 1) 0.1 0.1 0.3 -0.5 -0.2 0.3
Smoking status: Current 1.3 2.1 5.2 0.7 -2.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.3 10.8 -0.0 1.5 -3.3
Whole body water mass 1.2 6.6 11.8 2.6 -3.4 1.2
Leg predicted mass (right) 0.6 3.5 4.0 2.0 -2.0 1.6
Arm fat mass (left) 0.1 0.6 1.5 0.5 -0.3 1.2
Number of self-reported non-cancer illnesses 1.6 2.8 8.2 0.6 -2.9 0.1
Average weekly champagne plus white wine intake 1.9 2.6 7.6 0.1 2.8 0.2
Miserableness 0.0 0.1 0.2 -0.4 -0.1 0.2
Guilty feelings 1.0 1.5 2.4 1.6 -1.4 0.4
Wears glasses or contact lenses 1.7 1.9 3.0 1.5 -1.7 0.6
Ever taken oral contraceptive pill 1.4 1.5 2.8 1.7 -1.2 -0.6
Hearing aid user 0.6 0.7 1.7 -0.4 -1.3 -0.5
Mother’s age at death 0.6 0.7 1.1 1.1 -1.0 0.3
Financial situation satisfaction 0.2 0.3 0.6 0.8 0.5 -0.1
Tinnitus: Yes, now most or all of the time 1.3 1.5 2.5 -1.6 -0.8 -1.1
Commuting to job workplace: Public transport 1.4 1.6 3.3 0.3 -1.2 -1.8
Eye problems/disorders: Glaucoma 0.0 0.0 0.1 -0.1 -0.3 -0.1
Medication: Blood pressure 0.1 0.2 0.3 -0.4 -0.3 -0.6
Pain type(s) experienced in last month: Hip pain 1.5 1.9 5.0 -0.5 -0.6 2.2
Supplements: Fish oil (including cod liver oil) 1.3 1.7 3.1 -0.1 -1.4 -1.8
High cholesterol (Self-reported) 0.7 1.2 2.0 -1.4 -1.2 -0.2
Medication: Bendroflumethiazide 0.4 0.6 1.7 1.3 0.4 -0.3
Medication: Paracetamol 1.2 1.9 2.6 1.0 -1.6 1.5
Medication: Lisinopril 0.4 0.5 1.4 -1.2 0.2 -0.4
Medication: Atorvastatin 3.4 4.2 8.0 0.1 -2.8 2.2
Illnesses of father: High blood pressure 0.2 0.3 0.4 0.6 -0.2 0.6
Alcohol drinker status: Never 1.2 1.5 3.8 0.6 -1.9 -0.5
Ever smoked 0.5 0.8 1.2 -0.4 -1.1 1.1
Basal metabolic rate 1.0 5.5 9.4 2.3 -3.1 1.4
Leg fat percentage (left) 0.2 0.6 1.6 -0.2 -0.3 1.3
Arm fat-free mass (left) 1.4 7.0 14.4 2.3 -3.8 1.1
Number of operations (self-reported) 1.8 2.6 4.1 0.1 -2.0 -1.9
Average weekly beer plus cider intake 1.9 2.7 6.9 -0.8 -2.6 0.8
Irritability 0.7 1.2 1.8 1.3 -1.4 0.0
Risk taking 0.4 0.6 1.5 -0.2 -1.2 0.5
Ever had prostate specific antigen (PSA) test 1.2 1.4 3.2 -0.1 -1.0 -1.8
Fractured/broken bones in last 5 years 1.3 1.7 5.2 -0.0 0.2 2.3
Age started oral contraceptive pill 0.6 0.7 1.0 0.9 -0.5 -1.0
Diastolic blood pressure, automated reading 0.5 1.5 4.1 2.0 0.5 -0.1
Ever depressed for a whole week 1.6 1.9 4.0 2.0 0.7 1.1
Unable to work because of sickness or disability 1.2 1.6 2.5 0.5 -1.6 1.4
Commuting to job workplace: Cycle 0.2 0.3 0.6 0.3 -0.8 0.3
Myopia 0.1 0.1 0.2 0.2 -0.1 -0.5
Vascular/heart problems diagnosed by doctor 0.4 1.2 2.2 1.1 1.5 -0.3
Cholesterol lowering medication 1.8 2.6 5.8 0.6 -2.4 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.6 0.0 -0.5
Pain experienced in last month 0.5 0.8 2.3 0.1 1.5 0.3
Supplements: Calcium 0.8 0.9 2.5 -1.6 0.2 0.5
Basal cell carcinoma (self-reported) 0.5 0.7 1.0 -0.6 1.0 -0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.8 0.1 -0.3 1.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 2.0 0.1 0.3 -1.4
Heart disease (siblings) 0.4 0.5 0.7 0.6 -0.8 -0.5
Alcohol drinker status: Previous 2.8 3.2 6.0 1.9 -2.4 -0.4
Pack years of smoking 1.0 1.4 3.7 -0.4 -1.9 0.6
Impedance of whole body 0.4 2.0 4.4 -2.1 1.2 -0.5
Leg fat mass (left) 0.3 1.0 1.6 0.3 -1.3 1.2
Arm predicted mass (left) 1.4 6.9 13.8 2.3 -3.7 1.3