Hub : Genes

TRAPPC2P1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0255	0.0120	1.1e-03	0.022	0.021	0.017	NA	0.025	2.3e-05	2.8e-05	1.4e-04	NA	5.5e-06
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0615	0.0309	1.4e-03	0.010	0.020	0.008	NA	0.012	2.3e-02	2.3e-03	3.7e-02	NA	1.6e-02
3	TCGA	Lung Adenocarcinoma	0.0499	0.0244	1.7e-03	0.021	0.027	0.029	NA	0.019	1.3e-03	3.2e-04	2.0e-04	NA	2.1e-03
4	TCGA	Lung Squamous Cell Carcinoma	0.0350	0.0182	8.0e-04	0.001	0.028	0.019	NA	0.013	2.1e-01	3.5e-04	2.9e-03	NA	1.2e-02
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.1200	0.0520	6.0e-05	0.060	0.079	0.085	NA	0.073	6.5e-05	5.1e-06	2.4e-06	NA	1.1e-05
6	TCGA	Stomach Adenocarcinoma	0.0930	0.0480	5.7e-03	0.017	0.035	-0.001	NA	0.012	2.0e-02	1.4e-03	4.3e-01	NA	4.4e-02
7	TCGA	Testicular Germ Cell Tumors	0.3030	0.1180	6.4e-05	0.060	0.174	0.147	NA	0.126	3.6e-03	9.8e-07	7.3e-06	NA	3.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.4	2.0	-0.2	-0.3	-0.7	0.3	0.3	-1.4	0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	3.7	-0.2	-0.2	-1.9	-0.3	0.9	-1.8	-0.6
Depressed Affect (Nagel 2018)	1.4	3.0	7.7	-0.3	-0.5	-2.8	-2.1	-2.0	-0.4	-2.1
Depression (Nagel 2018)	0.6	0.8	1.9	-0.6	-0.9	-0.1	-1.1	-1.4	-1.1	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.0	0.2	0.4	0.3	-1.0	-0.5	-0.4	-0.6
Neuroticism (Nagel 2018)	0.6	1.5	4.6	-0.2	-0.6	-2.1	-1.3	-1.3	-0.7	-1.3
Schizophrenia (2018)	0.1	0.3	0.7	-0.1	-0.3	-0.6	-0.6	0.5	-0.8	-0.5
Schizophrenia vs Biploar Disorder	0.6	0.7	1.7	1.1	0.8	-0.3	-1.3	-0.5	-0.1	-1.1
Worry (Nagel 2018)	0.3	0.7	2.8	0.2	-0.3	-1.7	-0.3	-0.6	-0.5	-1.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	0.5	0.1	0.2	0.7	0.4	0.6	0.7
Alzheimer’s Disease (in father)	0.4	0.4	1.4	-0.3	0.3	-1.2	-0.7	-0.6	0.8	0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	2.0	0.3	-0.0	-1.4	-0.7	-0.6	0.3	-0.1
Crohns Disease (2017)	0.4	0.9	1.9	-1.4	-0.9	-0.1	-1.0	-1.2	-0.2	-1.0
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	0.1	-0.0	0.3	0.3	0.0	0.4	0.2
Ulcerative Colitis (UC)	0.5	0.9	1.7	1.2	0.6	0.9	1.1	0.9	0.5	1.3
Major Depression (MDD)	1.9	2.3	7.4	-0.5	-0.5	-1.4	-2.3	-0.6	-0.7	-2.7
Reaction Time	0.2	0.4	1.1	-0.6	-0.5	-0.8	-0.3	-1.1	0.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.7	0.9	1.3	1.2	-0.2	0.3	0.2	0.6
Breast Cancer	1.1	2.7	7.8	2.6	2.8	0.2	0.7	1.7	0.8	0.3
Ovarian Cancer	2.3	3.1	7.7	2.2	2.0	2.8	0.6	1.8	1.0	0.6
Prostate Cancer	0.6	0.8	3.0	-1.5	-1.7	0.5	0.4	-0.1	0.2	0.5
Age at First Birth	0.7	1.1	2.6	1.1	0.2	0.7	1.2	1.6	-0.7	1.1
Bipolar Disorder (2011)	0.2	0.2	0.7	0.4	0.5	0.0	-0.1	0.0	-0.3	0.8
Body Mass Index (BMI) (2010)	1.2	1.7	4.2	-0.6	-0.7	-0.8	-2.1	-1.3	-1.1	-1.8
Coronary Artery Disease (CAD)	0.9	1.1	2.8	0.8	1.6	1.7	0.9	0.0	0.5	0.9
Crohns Disease (2012)	0.9	1.4	5.0	-0.2	-0.3	0.0	-2.2	-0.9	-0.9	-1.7
Mean Putamen Volume	0.5	0.5	1.1	-0.9	-1.1	0.4	-0.3	-0.4	-1.1	-0.5
Fasting Glucose	0.1	0.1	0.5	-0.7	-0.3	-0.3	-0.2	-0.0	-0.3	-0.4
HbA1C	1.1	1.2	2.2	0.8	0.6	1.2	1.5	1.4	0.1	1.5
HDL Cholesterol	1.5	2.5	5.3	0.9	0.9	1.7	2.0	2.3	0.5	2.0
LDL Cholesterol	0.5	0.8	2.2	-0.2	-0.7	-1.5	-0.4	-1.2	-1.0	-0.3
Lupus	1.2	1.7	5.1	1.2	1.0	1.4	1.2	0.4	1.1	2.3
Neuroticism (2016)	0.8	1.1	1.9	-0.7	-0.8	-1.2	-1.4	-0.7	-1.1	-1.2
Primary Biliary Cirrhosis	0.6	0.9	2.2	-1.4	-1.3	0.5	-0.1	0.0	-1.5	0.1
Rheumatoid Arthritis	0.3	0.5	0.9	-0.1	0.7	1.0	0.3	0.8	-0.5	0.9
Schizophrenia (2014)	0.4	0.9	3.0	-0.4	-0.8	-1.7	-0.8	-0.4	-1.0	-0.9
Triglycerides	1.1	1.8	4.8	0.1	-0.5	-1.7	-1.8	-2.2	-0.4	-1.1
Type 2 Diabetes (T2D) (2012)	1.2	1.3	3.0	-0.7	-1.3	-0.3	-1.7	-0.9	-1.7	-0.7
Ulcerative Colitis	0.2	0.2	0.9	0.4	0.1	0.0	0.5	-0.5	0.0	0.9
Blood Eosinophil Count	0.1	0.9	2.6	0.1	0.6	0.9	-0.2	1.6	-1.6	-0.5
Blood Platelet Count	0.5	5.5	11.2	1.8	2.0	3.0	2.5	3.3	-0.7	2.2
Blood Red Count	0.1	1.4	3.9	-0.5	0.2	-1.0	-1.9	-2.0	0.8	-0.7
Blood White Count	0.1	0.7	2.1	0.7	0.4	1.4	1.1	0.2	0.9	0.4
Heel T-Score	0.1	1.2	2.8	-1.4	-1.4	1.1	0.2	-0.4	0.0	1.7
BMI	0.3	1.9	7.1	-1.2	-0.8	1.1	-1.4	0.9	-2.7	-0.7
Height	0.7	14.2	32.9	-4.3	-2.4	-5.7	-2.6	-5.0	0.9	-3.1
Waist Hip Ratio (WHR)	0.1	0.4	1.2	-0.6	-0.4	-0.1	-0.0	1.1	-0.9	-0.7
Systolic Blood Pressure	0.1	0.3	1.3	0.2	0.1	-1.1	-0.2	-0.5	0.7	-0.6
Smoking Status	1.1	2.6	3.6	-1.6	-1.7	-1.0	-1.8	-1.9	-1.6	-1.4
Allergy or Eczema	0.3	0.8	2.8	0.4	-0.0	1.7	-1.2	0.0	-0.1	-1.1
Cardiovascular Disease	0.7	2.5	4.5	-1.6	-1.5	-1.6	-1.5	-1.0	-1.5	-2.1
Hypothyroidism (self reported)	1.1	2.5	4.7	-1.9	-2.1	-0.3	-1.2	-2.2	-1.8	-0.1
Respiratory disease	0.8	1.7	3.9	2.0	1.6	0.2	1.2	1.6	0.3	1.1
Type 2 Diabetes (T2D) (2018)	1.2	2.3	4.4	-0.7	-0.5	-1.9	-2.1	-0.6	-1.7	-2.1
Lung FEV1/FVC ratio	0.2	1.2	4.0	1.1	-0.1	2.0	0.9	1.2	-1.0	-0.4
Lung FVC	0.0	0.2	1.2	-0.0	-0.1	0.2	-0.5	-1.1	0.2	0.2
Neuroticism	0.6	1.4	4.6	0.0	-0.1	-2.1	-1.2	-1.4	-0.3	-1.2
Chronotype (morning person)	0.3	0.6	1.7	1.2	1.3	-0.8	0.6	0.5	-0.0	-0.0
Hair Pigment	0.0	1.1	2.7	1.3	1.6	1.2	0.2	1.1	-0.6	-0.3
Tanning	0.0	0.2	0.4	0.0	0.3	-0.6	0.1	0.3	0.0	-0.7
Hand grip strength (left)	0.1	0.4	1.5	-1.2	-0.3	0.1	-0.0	-0.9	0.3	0.2
Number of treatments/medications taken	0.4	0.7	1.4	0.4	0.3	-1.2	0.7	-0.9	0.9	1.1
Average weekly spirits intake	0.6	0.7	2.6	0.6	0.7	0.8	0.9	1.6	-0.4	0.3
Sensitivity / hurt feelings	0.4	0.6	2.0	1.2	1.4	-0.7	-0.1	-0.3	0.1	-0.0
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.3	-0.8	-1.3	-1.4	-1.5	-1.0	-1.0	-1.2
Hearing difficulty/problems: Yes	0.6	0.9	4.8	0.1	-0.3	-0.3	0.8	-1.0	2.2	0.2
Relative age of first facial hair	0.3	0.5	2.0	1.4	0.6	-0.4	0.2	0.5	0.3	-0.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.9	-1.6	-1.6	-0.6	0.3	-2.0	-0.2	-0.4
Ever used hormone-replacement therapy (HRT)	1.9	2.5	7.5	1.1	1.6	1.7	1.0	-0.3	1.5	2.7
Ever had hysterectomy (womb removed)	1.8	2.0	6.1	-1.5	-1.1	-2.5	-0.8	-1.7	0.2	-0.9
Systolic blood pressure, automated reading	0.7	2.0	3.4	1.4	1.6	1.0	1.5	1.0	1.8	1.5
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.7	-1.6	-1.4	-1.0	-0.1	-0.7	0.6	-1.3
Angina	0.3	0.4	1.1	0.7	0.2	0.6	0.7	1.0	0.5	0.7
Medication for hormone replacement therapy	0.7	0.7	1.9	0.6	0.5	-0.2	1.3	0.3	1.0	1.4
Vitamin and mineral supplements	2.2	3.0	7.3	1.0	0.8	2.1	2.3	2.7	0.8	1.3
Supplements: Zinc	0.7	0.7	1.8	-0.6	-0.2	-0.8	-1.3	-1.2	-0.7	-0.7
Medication: Co-codamol	0.5	0.6	1.6	0.3	0.4	1.2	0.4	1.2	0.5	0.8
Medication: Metformin	0.4	0.5	1.8	-0.7	-0.6	-0.5	-0.3	0.7	-1.3	-0.5
Diabetes (father)	0.1	0.2	0.8	-0.3	-0.2	0.9	-0.5	-0.3	0.1	-0.1
Diabetes (mother)	2.0	2.5	5.2	2.3	1.5	0.1	1.6	1.7	0.7	2.0
Severe depression (siblings)	0.4	0.4	1.2	-1.1	-0.7	0.2	-0.2	-0.7	-0.0	-0.9
Pack years adult smoking proportion	0.4	0.6	1.0	-1.0	-0.9	0.4	-0.7	-0.9	-0.5	-0.9
Impedance of leg (right)	1.0	4.9	12.5	2.7	2.7	1.0	2.1	0.8	3.5	0.9
Leg fat-free mass (left)	1.4	7.5	15.3	-3.9	-2.7	-2.1	-2.7	-2.4	-2.7	-2.1
Trunk fat percentage	0.6	2.4	6.2	0.4	0.9	2.4	1.2	2.5	-0.4	1.4
Hand grip strength (right)	0.1	0.3	0.6	-0.8	0.1	0.5	0.1	-0.7	0.8	0.1
Townsend deprivation index at recruitment	0.3	0.4	1.2	0.1	-0.1	-0.8	-0.2	-1.1	0.7	-0.8
Current tobacco smoking	2.1	3.4	5.7	-1.9	-1.5	-1.4	-2.4	-1.8	-1.9	-1.9
Average weekly fortified wine intake	0.4	0.4	1.1	0.4	0.2	0.1	-1.1	0.8	-0.6	-0.8
Maternal smoking around birth	1.0	1.4	4.9	0.6	0.2	-1.0	0.3	-1.3	2.2	-1.4
Fed-up feelings	0.3	0.6	2.9	-0.3	0.1	-1.7	-0.5	-0.8	0.5	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.7	0.2	-0.1	-0.2	-0.4	-0.0	-0.8	-0.3
Relative age voice broke	0.5	0.8	1.6	1.3	0.9	0.3	1.0	0.9	0.2	1.1
Taking other prescription medications	0.4	0.7	2.0	0.9	-0.2	-0.2	1.3	0.0	0.3	1.4
Age when periods started (menarche)	0.2	0.6	2.1	1.4	0.9	-0.5	0.3	0.8	-0.2	0.1
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	7.8	-2.1	-2.2	-1.6	-1.1	-2.8	-0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.5	-1.2	-1.2	0.7	-0.9	-0.9	-1.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.5	-0.1	0.5	0.1	-1.6	-0.6	-0.0	-0.5
Qualifications: CSEs or equivalent	0.3	0.4	1.7	-0.6	0.2	-0.5	0.3	-0.6	0.5	-1.3
Serious illness, injury or assault to yourself	2.1	2.5	4.4	-1.3	-1.8	-0.8	-1.9	0.2	-2.1	-2.0
High blood pressure	0.1	0.2	0.5	-0.0	0.6	-0.7	0.5	0.0	-0.1	0.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.4	1.1	0.4	1.8	-0.8	0.4	0.1	-0.6
Multivitamins +/- minerals	1.6	2.1	5.3	-1.0	-0.7	-1.9	-1.5	-2.3	-0.7	-1.3
Stomach or abdominal pain in last month	0.6	0.8	1.6	-0.6	0.2	-1.2	-1.2	-0.8	-0.3	-1.3
Supplements: Glucosamine	0.7	0.9	3.5	-1.0	0.1	-0.6	-1.1	0.3	-1.9	-0.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.4	-0.8	-0.9	-1.5	-1.5	-1.2	-0.3	-1.5
Medication: Atenolol	1.1	1.4	4.6	2.1	1.2	-0.5	0.2	1.4	-0.4	1.0
Medication: Levothyroxine sodium	1.3	2.3	5.8	-1.9	-2.4	-0.0	-0.5	-2.3	-0.7	-0.5
Sitting height	0.8	5.6	9.3	-1.9	-1.1	-2.7	-3.1	-3.0	-0.9	-2.8
Chronic bronchitis/emphysema (father)	2.4	2.8	3.5	1.9	1.5	1.5	1.9	1.8	1.2	1.8
High blood pressure (mother)	0.7	1.0	2.8	-0.6	-0.8	-1.7	-0.9	-0.1	-1.1	-1.2
Body mass index (BMI)	0.2	0.9	2.3	-0.2	0.1	1.0	0.2	1.5	-1.4	0.8
Impedance of leg (left)	1.0	4.7	12.5	2.5	2.5	1.1	2.2	0.8	3.5	0.9
Leg predicted mass (left)	1.4	7.5	15.5	-3.9	-2.7	-2.1	-2.8	-2.4	-2.7	-2.0
Trunk fat mass	0.1	0.6	1.3	-0.9	-0.1	0.9	0.1	1.1	-1.0	0.4
Waist circumference	0.2	0.7	2.4	-1.3	-0.7	-0.5	-0.2	0.6	-1.5	-0.2
Number of incorrect matches in round	0.6	1.0	3.4	-0.2	-0.6	-0.8	-0.2	-1.7	1.8	0.2
Past tobacco smoking	0.2	0.5	1.7	0.1	0.2	1.3	-0.1	0.9	-0.6	0.4
Alcohol usually taken with meals	0.8	1.4	3.3	-0.6	-1.5	0.4	-1.5	-0.5	-1.8	-1.0
Nervous feelings	1.0	1.9	5.9	-0.9	-1.0	-2.4	-0.7	-1.5	-1.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.4	0.1	-0.5	-1.2	-1.7	-1.3	-0.3	-1.8
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.1	-0.8	-0.5	0.2	-0.8	0.5	-0.6
Hair/balding pattern: Pattern 2	1.5	1.9	4.7	1.1	1.2	2.2	1.0	1.8	1.1	0.2
Had menopause	1.6	2.0	5.9	1.0	1.4	1.3	1.1	1.2	0.8	2.4
Had other major operations	2.2	2.7	7.3	-1.0	-0.7	-2.7	-1.4	-2.6	0.5	-1.2
Forced vital capacity (FVC)	0.8	3.2	5.3	-2.0	-1.4	-1.6	-2.3	-2.3	-1.2	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	-1.0	-0.9	0.4	0.2	-0.6	-0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.7	0.3	0.5	0.6	0.2	0.3	0.3
Qualifications: None of the above	0.5	1.0	2.6	0.9	1.2	0.3	0.7	0.9	1.6	0.7
Financial difficulties in last 2 years	8.0	10.8	16.7	-3.2	-2.7	-2.7	-4.1	-3.4	-3.6	-3.0
Mouth/teeth dental problems	0.3	0.5	1.3	1.2	0.3	-0.1	0.9	1.0	0.6	0.5
Heart attack	0.5	0.6	2.1	0.9	0.6	-0.0	-0.1	1.5	-1.0	-0.1
Allergy	0.2	0.4	0.9	-0.6	-0.3	-0.9	1.0	0.2	-0.1	0.5
Pain all over the body in last month	0.9	0.9	1.9	-0.6	-1.0	-0.4	-1.1	-0.6	-1.4	-1.2
Diabetes (self-reported)	0.5	0.8	1.7	-0.7	-0.0	-1.1	-1.1	0.4	-1.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	0.3	-0.2	0.2	0.1	-0.3	0.1	0.1
Medication: Ramipril	1.0	1.3	2.9	-1.3	-1.1	-1.4	-0.3	-1.1	0.1	-1.7
Medication: Simvastatin	0.3	0.4	1.1	0.7	0.4	-1.1	-0.1	0.2	0.8	-0.6
Fluid intelligence score	1.9	4.0	6.7	2.5	2.6	2.3	0.9	2.2	0.4	2.0
Illnesses of siblings	0.1	0.2	0.5	0.5	0.7	0.0	-0.5	0.2	0.3	-0.3
Neuroticism score	1.4	2.9	8.4	-0.4	-0.3	-2.9	-1.9	-1.8	-0.9	-2.0
Weight	0.4	1.7	4.6	-2.1	-1.2	-1.0	-1.3	-0.7	-1.6	-0.7
Impedance of arm (right)	0.4	1.9	4.8	1.1	1.6	2.2	1.3	1.5	0.7	0.8
Arm fat percentage (right)	0.6	2.3	6.4	0.1	0.6	2.4	1.0	2.5	-1.1	1.2
Trunk fat-free mass	2.2	12.9	22.9	-4.4	-3.2	-4.8	-3.2	-3.8	-1.9	-3.0
Hip circumference	0.1	0.6	1.9	-1.0	-0.4	-0.3	-0.8	0.4	-1.4	-0.4
Time employed in main current job	2.1	2.4	8.2	1.4	0.8	1.9	1.0	2.9	-0.8	0.9
Alcohol intake versus 10 years previously	0.3	0.5	1.1	-1.1	-0.9	-0.8	0.1	-0.7	-0.5	-0.5
Father’s age at death	0.3	0.4	1.0	-1.0	-0.7	0.3	-0.6	-0.1	-0.6	-0.3
Worrier / anxious feelings	0.1	0.2	0.6	-0.4	-0.7	-0.1	-0.3	-0.8	-0.3	-0.3
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.1	11.3	-2.0	-2.0	-2.6	-2.9	-1.9	-2.3	-3.4
Falls in the last year	0.2	0.3	0.7	0.5	0.8	0.7	-0.2	0.8	-0.2	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.9	-0.6	-0.5	0.1	-0.5	0.2	0.5
Number of live births	0.7	1.0	2.8	0.8	0.1	1.1	1.4	-0.1	1.7	0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.9	-1.1	-1.0	-0.5	-2.0	-1.3	-1.4	-1.5
Pulse rate	0.2	0.3	0.5	0.5	0.5	0.6	0.7	0.3	-0.4	0.7
Happiness	0.5	0.6	1.6	0.4	0.4	-1.2	-1.1	-0.8	-0.2	0.8
Noisy workplace	0.2	0.3	0.7	-0.4	-0.1	0.5	0.5	0.6	0.8	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.6	0.3	0.6	-0.1	0.4	-0.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	5.5	-1.6	-2.3	0.2	-2.3	-1.8	-1.8	-1.8
Mouth/teeth dental problems: Dentures	0.3	0.6	2.2	-1.5	-0.6	1.0	0.4	0.3	-0.2	0.1
Asthma	1.0	2.0	3.5	1.9	1.3	0.6	1.6	1.4	0.9	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.6	-0.1	-0.1	0.0	-0.4	-1.3	-0.5	-0.3
Medication: Cholesterol lowering	1.2	1.9	4.1	-1.9	-2.0	-1.2	-0.4	0.3	-1.4	-1.3
Depression (self-reported)	1.4	1.7	3.1	-1.7	-1.5	-0.7	-1.2	-1.8	-1.2	-0.8
Medication: Lansoprazole	0.6	0.7	2.6	-0.2	-0.9	0.1	1.6	0.8	-0.2	0.8
Prospective memory result	0.9	1.1	3.2	0.4	-0.8	-1.1	-1.0	-1.8	0.5	-1.0
Lung cancer (father)	0.4	0.5	1.3	0.3	0.8	-0.2	-0.2	0.9	-1.1	0.6
Illnesses of mother	0.3	0.3	1.2	-0.1	0.9	1.1	-0.3	-0.4	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.3	-1.0	-1.0	-0.6	-2.1	-1.7	-1.3	-1.5
Pulse wave Arterial Stiffness index	0.6	0.7	2.4	-0.8	-0.7	-0.5	-0.4	-1.5	0.0	-0.9
Impedance of arm (left)	0.7	3.4	7.8	1.8	2.0	2.8	1.6	1.9	0.8	1.3
Arm fat mass (right)	0.1	0.6	1.3	-0.7	0.0	1.0	0.1	1.2	-1.1	0.6
Trunk predicted mass	2.3	13.2	23.6	-4.5	-3.2	-4.9	-3.2	-3.9	-2.0	-3.0
Standing height	1.3	13.3	21.8	-4.4	-2.9	-4.6	-3.3	-4.7	-0.8	-3.3
Length of working week for main job	1.7	1.8	3.2	-0.7	-1.2	-1.8	-1.8	-1.7	-0.9	-1.0
Exposure to tobacco smoke at home	0.5	0.6	2.3	-1.0	-1.5	-0.1	-0.4	0.1	-0.2	-0.6
Breastfed as a baby	0.7	0.8	2.5	-0.6	-1.6	-0.8	-0.4	-0.3	-1.3	-0.4
Tense / ‘highly strung’	0.5	0.8	4.0	-0.2	0.1	-2.0	-0.5	-0.2	-0.7	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	3.7	5.7	15.0	-2.0	-2.0	-1.8	-2.8	-3.9	-0.3	-2.4
Hair/balding pattern: Pattern 4	0.5	1.2	3.1	1.8	0.9	1.1	0.6	1.6	0.3	0.6
Birth weight of first child	0.6	1.1	2.6	-1.6	-1.6	-1.5	0.1	-0.5	0.1	-0.4
Peak expiratory flow (PEF)	0.2	0.5	1.1	0.5	0.6	0.0	-1.0	0.5	-1.1	-0.8
Pulse wave reflection index	0.3	0.3	0.8	-0.5	-0.9	0.9	-0.3	-0.4	0.2	-0.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.8	-0.5	-0.2	1.2	-1.4	-0.6	0.1	-1.3
Loud music exposure frequency	0.3	0.4	1.5	0.2	0.2	-0.2	-1.2	-0.6	0.2	-0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.2	-1.0	-1.1	0.5	-0.9	-0.6	-1.0	-0.3
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.1	-0.6	-0.5	-1.1	-1.8	-0.6	-1.5	-1.6
Blood clot in the leg (DVT)	1.6	2.1	4.2	-1.9	-1.0	-0.7	-1.7	-2.0	-0.9	-1.3
Medication: Paracetamol	0.2	0.3	0.7	-0.5	-0.2	-0.2	-0.8	-0.7	-0.7	-0.4
Headache pain in last month	0.3	0.5	1.2	0.6	0.8	0.4	-1.1	-0.2	-0.3	-0.9
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.3	1.7	1.9	2.3	-0.1	0.9	0.7	1.2
Glaucoma (self-reported)	1.0	1.2	4.4	0.8	0.0	1.1	1.0	-0.9	2.1	0.4
Gout (self-reported)	0.5	0.7	1.5	1.2	0.6	1.0	0.2	0.8	-0.6	1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.8	-1.2	-1.7	0.5	-0.3	-1.0	-1.2	0.4
Medication: Amlodipine	0.5	0.7	1.9	0.6	0.7	-1.0	1.4	0.1	0.4	1.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.7	0.4	0.5	0.0	-0.6	0.6	0.4
Birth weight	0.2	0.5	1.5	0.1	0.9	-0.7	0.3	-0.6	0.6	1.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.0	-0.2	-0.2	1.0	-0.4	0.2	0.5	-0.1
High blood pressure (siblings)	0.7	1.1	3.3	-1.2	-1.8	-0.8	-0.3	-0.7	-1.1	-0.7
Forced vital capacity (FVC), Best measure	1.2	4.4	7.9	-2.1	-1.7	-1.6	-2.8	-2.8	-1.7	-1.6
Body fat percentage	0.5	2.0	4.8	0.4	0.9	2.2	1.2	2.2	-0.2	1.4
Leg fat percentage (right)	0.5	1.9	3.8	0.9	1.1	1.9	1.3	1.8	0.4	1.5
Arm fat-free mass (right)	1.4	7.0	12.1	-3.5	-2.5	-3.5	-2.4	-2.7	-1.6	-1.8
Exposure to tobacco smoke outside home	0.8	1.0	1.6	-1.1	-1.2	-1.1	-0.9	-0.3	-1.2	-0.9
Comparative body size at age 10	0.6	1.7	5.7	-1.3	-0.9	-1.1	-1.1	-0.3	-2.4	-1.1
Number of full brothers	0.4	0.5	1.6	-0.7	-0.8	-0.1	0.8	0.2	-1.3	0.6
Worry too long after embarrassment	2.3	3.8	8.1	-1.6	-1.7	-2.9	-1.7	-2.0	-2.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	11.9	-1.7	-1.8	-2.8	-0.9	-3.5	0.5	-1.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	-0.6	-0.1	0.1	-0.9	-0.4	-0.1	-0.5
Number of children fathered	0.3	0.3	1.5	-0.7	-1.2	-0.2	-0.0	-0.4	0.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.3	-0.1	0.6	1.5	0.2	0.8	-0.3	-0.3
Age at first live birth	1.3	2.2	4.7	-1.3	-2.1	1.3	-1.4	-0.3	-2.2	-1.1
Pulse wave peak to peak time	0.4	0.5	1.8	0.7	0.6	0.1	0.3	1.3	0.1	0.8
Health satisfaction	0.9	1.1	2.8	-0.3	-0.7	-1.1	-1.7	-1.0	-1.0	-1.0
Shortness of breath walking on level ground	0.1	0.1	0.5	0.4	0.7	-0.2	-0.2	-0.4	0.2	0.2
Qualifications: College or University degree	0.4	1.1	2.2	-0.7	-1.2	0.6	-1.4	-0.9	-1.5	-0.8
Eye problems/disorders: None of the above	1.2	1.3	2.1	-1.2	-0.8	-1.0	-1.3	-1.4	-0.9	-1.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.5	-0.6	-1.2	-0.3	-1.4	-1.9	-0.8	-1.6
Emphysema/chronic bronchitis	0.4	0.4	1.0	-1.0	-0.5	0.4	-0.9	-0.3	-0.7	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	-0.7	-0.7	-0.3	-0.2	0.1	0.5	-0.9
Neck or shoulder pain in last month	0.2	0.2	0.6	-0.4	-0.0	-0.5	-0.6	-0.5	-0.3	-0.8
Medication: Blood pressure	0.5	1.0	4.6	-0.7	-0.8	-2.1	0.5	-0.2	-0.6	-0.6
Angina (self-reported)	0.4	0.6	1.6	0.6	0.3	0.9	0.7	1.2	0.2	0.8
Migraine (self-reported)	1.1	1.3	3.6	0.3	0.9	-1.7	-0.5	-1.9	1.1	0.6
Medication: Ibuprofen	0.3	0.4	2.0	-0.3	-0.2	-0.3	-0.5	-1.4	-0.5	-0.3
Medication: Allopurinol	0.3	0.4	1.1	0.7	0.2	-0.4	-0.3	1.0	-1.1	0.5
Medication: Omeprazole	0.6	0.7	0.9	0.9	0.8	0.9	-1.0	0.4	-0.8	0.9
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.9	0.3	-0.2	0.7	0.8	0.3	0.8
Mean time to correctly identify matches	0.5	1.0	2.0	-1.4	-0.6	-0.8	0.2	-1.4	1.2	0.2
Heart disease (mother)	0.5	0.6	1.3	0.5	-0.2	-1.2	0.8	1.1	-0.4	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	6.9	-0.8	-0.5	-1.4	-2.1	-0.2	-2.6	-1.8
Whole body fat mass	0.1	0.3	0.7	-0.8	-0.1	0.7	0.1	0.7	-0.7	0.3
Leg fat mass (right)	0.0	0.2	0.4	-0.6	0.0	0.5	0.1	0.5	-0.4	0.4
Arm predicted mass (right)	1.4	7.0	11.8	-3.4	-2.4	-3.4	-2.6	-2.7	-1.5	-1.9
Pulse rate, automated reading	0.2	0.8	2.4	0.7	1.5	0.4	0.7	0.8	-0.3	1.1
Alcohol intake frequency.	1.1	2.6	6.0	-0.9	-1.2	-2.5	-1.5	-2.2	-0.4	-1.8
Comparative height size at age 10	0.7	4.0	12.4	-1.8	-1.0	-2.7	-1.7	-3.5	-0.4	-0.8
Number of full sisters	0.8	1.0	2.4	-0.5	-1.5	-1.2	0.6	-1.6	0.3	-0.0
Suffer from ‘nerves’	1.3	2.0	5.4	-1.5	-1.1	-1.4	-1.0	-1.4	-0.2	-2.3
Overall health rating	1.2	2.6	4.5	-1.1	-1.2	-1.8	-2.1	-1.8	-1.1	-1.9
Chest pain or discomfort	1.9	2.8	4.7	-1.3	-0.8	-1.9	-2.1	-0.8	-1.9	-2.2
Had major operations	1.1	1.3	4.1	-0.5	-1.1	-1.0	-1.4	-0.1	-0.7	-2.0
Age at last live birth	1.9	2.8	6.8	-1.3	-2.6	0.5	-1.6	-1.4	-1.7	-1.7
Family relationship satisfaction	0.9	1.1	2.0	-1.2	-0.4	0.6	-1.3	-1.4	-1.0	0.9
Leg pain on walking	0.5	0.7	1.7	1.3	0.6	0.4	0.5	0.5	0.6	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	0.3	-0.2	-1.1	0.2	-0.7	0.5	-0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.1	1.0	1.1	0.6	0.5	0.2	0.5	0.0
Illness, injury, bereavement, stress in last 2 years	5.4	6.7	17.6	2.1	2.3	1.5	3.1	0.6	4.2	2.8
Medication: Aspirin	0.7	0.9	1.5	0.7	0.6	-0.9	1.2	0.6	1.2	1.0
Supplements: Vitamin C	3.8	4.5	11.6	-2.1	-1.7	-1.4	-2.7	-3.4	-0.9	-1.6
Knee pain experienced in last month	1.3	2.1	9.7	-1.0	-0.9	-1.0	-0.9	1.0	-3.1	0.1
Hypertension (Self-reported)	0.1	0.3	0.5	-0.1	0.6	-0.7	0.7	0.5	-0.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	5.1	0.3	0.3	0.8	0.8	0.4	0.6	2.3
Illnesses of father: Heart disease	0.3	0.4	1.5	0.1	-0.6	1.2	0.4	-0.3	0.5	0.5
Illnesses of siblings: Diabetes	0.1	0.1	0.6	0.4	0.0	0.3	0.8	0.3	-0.1	0.3
Smoking status: Previous	0.3	0.4	1.0	0.1	-0.1	-0.8	0.7	-0.8	1.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	7.4	-1.6	-1.2	-2.3	-2.7	-1.3	-2.2	-2.5
Whole body fat-free mass	1.8	10.6	17.9	-4.2	-3.0	-3.9	-3.0	-3.3	-2.2	-2.6
Leg fat-free mass (right)	1.7	8.8	17.1	-4.1	-3.1	-2.4	-3.0	-2.5	-3.0	-2.3
Arm fat percentage (left)	0.7	2.7	7.2	0.4	0.9	2.7	1.0	2.6	-1.0	1.5
Average weekly red wine intake	0.7	1.0	2.7	-0.6	-0.9	0.3	-1.6	-0.5	-1.5	-0.5
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.5	0.5	0.7	0.2	0.4	-0.6	1.0
Mood swings	2.5	4.5	11.7	-0.7	-1.0	-3.4	-2.2	-2.5	-0.6	-2.7
Loneliness, isolation	0.6	0.8	3.0	-0.8	-0.0	-1.2	-0.9	-1.7	-0.0	-0.4
Long-standing illness, disability or infirmity	0.4	0.5	2.8	-0.1	-0.2	-1.7	-0.4	-0.3	-0.3	-0.7
Ever had bowel cancer screening	0.6	0.7	1.8	-1.0	-1.1	-0.1	-0.7	-1.3	-0.2	-0.7
Diabetes diagnosed by doctor	0.8	1.2	3.1	-0.9	-0.5	-1.7	-1.3	-0.1	-1.1	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	0.7	-0.1	-0.2	0.3	0.0	-0.0	-0.2
Friendships satisfaction	0.7	0.9	2.1	0.8	1.0	1.5	0.3	0.7	-0.1	1.4
Qualifications: nursing, teaching	1.0	1.6	9.4	0.4	-0.1	3.1	0.3	1.1	0.1	0.0
Commuting to job workplace: Walk	2.9	3.2	10.0	-2.3	-1.4	0.8	-1.7	0.1	-3.2	-1.1
Eye problems/disorders: Cataract	0.7	0.8	2.2	0.4	0.2	0.8	0.8	1.5	0.1	1.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	1.1	0.1	0.4	0.9	0.3	-0.9	0.9	1.0
Medication for cholesterol	1.2	1.8	3.4	-1.8	-1.4	0.6	-1.1	-0.1	-1.6	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	0.9	1.0	-1.1	0.6	-0.2	0.1	-0.1
Back pain experienced in last month	1.4	2.1	4.9	-1.6	-0.9	-1.4	-1.9	-0.8	-0.4	-2.2
Mineral and other dietary supplements	0.4	0.6	3.0	0.5	-0.3	1.7	0.4	0.8	0.2	-0.0
Breast cancer (self-reported)	0.9	1.0	2.9	1.6	0.7	0.5	0.7	1.7	-0.4	0.7
Asthma (self-reported)	0.7	1.4	2.7	1.7	1.0	0.3	1.4	1.2	0.4	1.5
Osteoporosis (self-reported)	0.3	0.4	0.9	-0.8	-0.8	-0.8	0.2	-1.0	-0.3	0.1
Osteoarthritis (self-reported)	0.4	0.5	1.1	1.0	0.9	-0.1	-0.3	0.4	-0.8	0.7
Medication: Aspirin	0.5	0.7	1.8	0.5	0.9	-1.4	0.8	0.2	0.8	0.8
Medication: Gliclazide	0.4	0.4	1.1	0.3	0.7	-0.9	-1.1	-0.2	-0.4	-0.1
Illnesses of father: None of the above (group 1)	2.0	2.5	5.7	-1.3	-0.1	-1.8	-2.1	-0.6	-1.6	-2.4
Smoking status: Current	1.4	2.3	4.7	-1.6	-1.2	-0.8	-2.2	-1.3	-1.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	10.5	-1.6	-1.8	-1.7	-2.2	-3.2	0.2	-2.7
Whole body water mass	1.8	10.3	18.0	-4.2	-3.1	-3.8	-3.0	-3.2	-2.3	-2.6
Leg predicted mass (right)	1.6	8.5	16.8	-4.1	-3.1	-2.2	-2.9	-2.5	-2.9	-2.2
Arm fat mass (left)	0.2	0.7	1.7	-0.6	0.1	1.0	0.1	1.3	-1.2	0.6
Number of self-reported non-cancer illnesses	0.5	0.9	3.5	-0.6	-0.9	-1.1	-0.5	-1.9	0.3	-0.3
Average weekly champagne plus white wine intake	0.9	1.2	4.6	0.4	1.0	1.1	-0.2	2.1	-1.1	0.1
Miserableness	2.5	4.4	11.7	-0.4	-1.1	-3.4	-2.6	-1.4	-1.6	-2.5
Guilty feelings	1.1	1.7	4.3	-1.1	-0.4	-2.1	-1.7	-0.9	-0.7	-1.5
Wears glasses or contact lenses	0.5	0.5	1.1	-0.7	-1.0	0.0	1.0	0.3	1.0	0.4
Ever taken oral contraceptive pill	3.6	4.0	7.6	-2.1	-2.3	-2.8	-1.5	-2.2	-1.4	-1.4
Hearing aid user	0.6	0.7	2.5	-1.1	-1.6	-0.4	0.2	-0.8	0.3	-0.1
Mother’s age at death	0.9	1.2	3.6	0.6	1.0	0.3	0.4	-0.3	1.7	1.9
Financial situation satisfaction	0.9	1.1	4.1	0.4	0.3	-0.0	-2.0	-0.3	-1.5	-0.9
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.2	-0.4	-0.1	-1.6	0.1	-1.8	1.5	0.2
Commuting to job workplace: Public transport	1.1	1.4	3.3	-1.5	-1.5	-0.4	-0.9	-1.8	0.5	-0.6
Eye problems/disorders: Glaucoma	0.9	1.1	2.8	1.6	0.7	0.9	0.7	-0.1	1.7	0.4
Medication: Blood pressure	0.2	0.4	1.3	1.2	0.7	-0.2	-0.4	0.4	-0.3	0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	0.1	0.1	0.3	0.6	1.3	-0.5	0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.7	0.2	0.6	-0.8	0.5	-0.2	0.7	0.7
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.4	-0.3	-0.9	0.8	0.9	0.3	0.0
Medication: Bendroflumethiazide	0.6	0.9	2.9	1.0	1.7	1.0	0.4	1.1	0.0	0.7
Medication: Paracetamol	0.2	0.4	0.8	-0.5	0.2	-0.7	-0.9	-0.5	-0.9	-0.4
Medication: Lisinopril	0.3	0.3	1.0	-0.3	-0.3	-0.7	-0.7	0.0	-1.0	-0.3
Medication: Atorvastatin	1.0	1.3	3.6	-1.9	-1.7	-0.6	0.1	-0.8	0.1	-1.1
Illnesses of father: High blood pressure	0.2	0.3	0.9	-0.6	-0.9	0.0	-0.1	0.1	-0.9	-0.3
Alcohol drinker status: Never	1.5	1.7	6.8	0.1	-0.6	-0.7	0.0	-2.1	2.6	-0.3
Ever smoked	0.4	0.7	2.1	-0.1	-0.2	-1.4	-0.5	-0.9	0.2	-1.4
Basal metabolic rate	1.6	8.9	16.3	-4.0	-2.8	-3.3	-2.9	-2.9	-2.3	-2.4
Leg fat percentage (left)	0.5	2.0	4.8	0.7	0.9	2.2	1.3	1.9	0.3	1.5
Arm fat-free mass (left)	1.5	7.8	13.6	-3.5	-2.6	-3.7	-2.6	-2.6	-1.7	-2.2
Number of operations (self-reported)	1.7	2.5	5.4	-1.2	-1.1	-2.3	-1.7	-2.1	0.3	-1.4
Average weekly beer plus cider intake	1.0	1.4	2.4	1.3	1.4	-0.9	1.6	1.4	1.0	0.4
Irritability	1.1	1.8	3.8	-0.2	-0.5	-2.0	-1.9	-1.8	-0.4	-1.3
Risk taking	0.2	0.3	0.8	0.8	0.1	-0.9	0.5	0.4	0.1	0.3
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.0	-1.6	-2.0	-1.2	-0.6	-1.4	0.1	-1.3
Fractured/broken bones in last 5 years	3.1	4.0	5.6	-2.3	-2.2	-1.0	-2.3	-1.4	-2.4	-2.0
Age started oral contraceptive pill	0.7	0.8	4.1	0.6	0.2	0.5	0.5	-0.5	0.8	2.0
Diastolic blood pressure, automated reading	0.1	0.2	0.8	0.3	0.9	-0.1	-0.4	-0.3	0.6	0.2
Ever depressed for a whole week	0.6	0.7	2.3	-0.5	-0.1	1.5	0.1	0.1	-0.5	1.5
Unable to work because of sickness or disability	0.2	0.2	1.1	-0.4	-1.0	0.1	0.2	-0.4	0.5	0.2
Commuting to job workplace: Cycle	0.3	0.4	0.9	0.6	0.8	-0.8	-0.5	-0.9	0.2	-0.1
Myopia	0.3	0.5	0.9	-0.8	-0.7	0.5	-0.7	-0.9	-0.0	-0.9
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.6	-0.1	-0.4	0.8	-0.6	0.1	-0.1	-0.5
Cholesterol lowering medication	0.9	1.3	3.5	1.1	0.8	-1.9	0.0	-1.0	1.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.4	0.0	-0.2	0.1	-1.9	-0.0	-1.8	0.2
Pain experienced in last month	0.3	0.5	1.2	-0.5	-0.6	0.6	0.8	-0.3	0.5	1.1
Supplements: Calcium	1.7	1.9	3.2	-1.8	-1.3	0.2	-1.8	-1.5	-0.5	-1.7
Basal cell carcinoma (self-reported)	0.4	0.4	1.3	-0.0	0.2	1.1	0.4	-0.5	1.0	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.6	2.0	0.9	0.8	-0.1	0.0	1.4	-0.8	0.1
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.5	-1.9	-1.0	-0.6	-1.5	-1.9	-0.9	-1.3
Heart disease (siblings)	0.2	0.2	0.6	0.2	0.8	-0.6	-0.2	-0.4	0.4	0.1
Alcohol drinker status: Previous	2.8	3.1	9.1	-1.1	-0.6	-3.0	-2.2	-1.5	-1.1	-1.8
Pack years of smoking	0.2	0.4	0.7	-0.8	-0.6	0.7	-0.5	-0.7	-0.3	-0.4
Impedance of whole body	0.8	3.9	5.7	2.3	2.4	2.2	1.8	1.6	2.1	1.1
Leg fat mass (left)	0.1	0.3	0.5	-0.6	0.1	0.7	0.0	0.7	-0.6	0.5
Arm predicted mass (left)	1.5	7.6	12.2	-3.5	-2.5	-3.5	-2.6	-2.8	-1.5	-2.3