Hub : Genes

ZNF587B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0628	0.0288	0.0037	0.009	NA	0.008	NA	0.001	4.1e-02	NA	0.05400	NA	2.3e-01
2	GTEx	Skin Sun Exposed Lower leg	0.1100	0.0440	0.0027	0.008	NA	0.000	NA	0.013	6.7e-02	NA	0.33000	NA	2.5e-02
3	GTEx	Testis	0.1290	0.0570	0.0085	0.075	NA	0.074	NA	0.042	3.3e-04	NA	0.00034	NA	5.8e-03
4	GTEx	Whole Blood	0.0770	0.0370	0.0047	0.069	NA	0.022	NA	0.059	5.5e-07	NA	0.00360	NA	4.0e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.9	1.4	0.6	1.2	-1.0	0.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.6	0.1	-0.1	0.8
Depressed Affect (Nagel 2018)	0.8	1.6	3.5	-0.4	-1.5	0.9	-1.9
Depression (Nagel 2018)	0.1	0.2	0.2	-0.5	0.5	0.5	0.0
Intelligence (Savage-Jansen 2018)	0.6	1.7	5.2	-0.9	0.8	-0.4	2.3
Neuroticism (Nagel 2018)	0.2	0.6	1.2	0.6	-0.5	0.6	-1.1
Schizophrenia (2018)	0.2	0.4	0.8	0.3	-0.8	0.9	0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.4	0.2	0.9	-1.2	1.0
Worry (Nagel 2018)	0.3	0.7	2.4	-0.2	-0.5	0.0	-1.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.3	-0.5	0.6	-0.3
Alzheimer’s Disease (in father)	1.3	1.5	2.8	-1.0	-1.7	1.4	-0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	1.3	-1.2	-1.0	1.1	-0.5
Crohns Disease (2017)	0.1	0.1	0.3	-0.5	-0.5	0.2	0.1
Irritable Bowel Disease (IBD)	0.2	0.6	1.5	-1.2	-0.8	0.4	-0.0
Ulcerative Colitis (UC)	0.5	0.9	2.6	-1.6	-0.7	0.4	0.4
Major Depression (MDD)	1.1	1.3	4.2	0.2	1.0	-2.1	-0.3
Reaction Time	0.9	1.7	4.9	0.1	-1.3	2.2	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	-1.1	0.3	-0.7	0.1
Breast Cancer	1.2	2.9	3.9	1.9	1.7	-2.0	1.0
Ovarian Cancer	1.2	1.6	3.7	-0.9	-1.3	1.9	-0.5
Prostate Cancer	2.6	3.6	5.9	2.4	2.3	0.4	1.8
Age at First Birth	0.2	0.3	0.8	0.4	0.9	-0.0	0.5
Bipolar Disorder (2011)	0.0	0.0	0.1	0.2	-0.1	-0.1	0.2
Body Mass Index (BMI) (2010)	2.0	2.7	9.1	0.3	1.1	-3.0	0.6
Coronary Artery Disease (CAD)	0.4	0.5	1.5	0.2	1.2	-0.3	0.4
Crohns Disease (2012)	0.4	0.6	1.8	-0.4	-1.4	-0.3	-0.5
Mean Putamen Volume	0.2	0.2	0.5	-0.7	0.1	-0.4	-0.3
Fasting Glucose	1.2	1.4	2.2	1.3	1.3	-1.5	0.1
HbA1C	3.3	3.7	7.4	1.6	2.7	-1.4	1.6
HDL Cholesterol	0.1	0.2	0.4	0.5	0.3	0.6	0.3
LDL Cholesterol	0.3	0.4	0.9	-0.3	-0.5	-0.5	-1.0
Lupus	0.6	0.9	2.7	1.6	0.3	0.3	0.8
Neuroticism (2016)	1.5	2.2	6.0	0.6	-1.5	-0.6	-2.4
Primary Biliary Cirrhosis	0.3	0.4	1.0	-1.0	-0.4	0.2	0.5
Rheumatoid Arthritis	1.7	2.3	5.6	2.4	1.2	0.3	1.4
Schizophrenia (2014)	0.3	0.6	1.0	0.7	0.9	-1.0	0.4
Triglycerides	0.5	0.8	2.4	-0.7	-0.1	-1.6	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.0	0.5	-0.5	-0.2
Ulcerative Colitis	0.2	0.2	0.7	0.3	-0.8	0.4	-0.1
Blood Eosinophil Count	1.3	10.3	23.1	2.5	3.4	0.1	4.8
Blood Platelet Count	0.5	5.4	12.0	2.7	3.5	-0.1	1.6
Blood Red Count	0.1	1.1	2.8	1.7	-0.4	-0.7	-1.0
Blood White Count	0.6	4.7	9.7	2.5	1.5	0.8	3.1
Heel T-Score	0.3	2.7	6.7	-0.6	0.8	1.8	2.6
BMI	0.4	2.1	5.4	-1.7	-0.1	-0.4	2.3
Height	0.7	13.3	32.3	-5.7	-3.2	1.0	-3.1
Waist Hip Ratio (WHR)	0.4	1.7	4.7	0.7	2.2	-1.1	0.5
Systolic Blood Pressure	0.6	2.8	7.5	0.2	-0.9	2.7	1.7
Smoking Status	0.6	1.6	2.6	-1.3	-1.4	-0.1	-1.6
Allergy or Eczema	0.9	2.3	4.0	0.4	2.0	-1.1	2.0
Cardiovascular Disease	0.3	1.0	2.5	1.6	0.3	-0.0	1.3
Hypothyroidism (self reported)	0.1	0.3	0.6	0.8	-0.6	-0.3	0.3
Respiratory disease	1.2	2.8	6.0	2.5	1.8	0.7	1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.3	-0.8	-0.4	0.5
Lung FEV1/FVC ratio	0.6	2.9	9.4	-3.1	-0.3	-0.9	1.2
Lung FVC	0.2	0.9	2.3	1.0	1.5	-0.2	0.4
Neuroticism	0.9	2.1	4.4	-0.2	-2.1	1.1	-1.7
Chronotype (morning person)	1.3	3.0	9.0	1.0	3.0	-1.4	-0.1
Hair Pigment	0.1	3.0	9.2	3.0	1.4	-0.7	-0.4
Tanning	0.3	3.9	5.6	-2.4	-2.2	1.4	-1.8
Hand grip strength (left)	0.1	0.2	0.4	0.5	0.6	0.2	0.6
Number of treatments/medications taken	1.6	2.9	11.4	3.4	0.3	0.0	0.2
Average weekly spirits intake	0.4	0.5	1.3	0.0	0.7	0.6	1.1
Sensitivity / hurt feelings	0.7	1.1	2.1	1.1	0.3	-1.0	-1.5
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	-0.7	-0.5	0.2	-1.0
Hearing difficulty/problems: Yes	1.8	2.8	9.3	0.1	1.0	0.9	3.0
Relative age of first facial hair	0.2	0.4	1.2	-0.0	-0.5	0.5	1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	-0.4	-1.3	0.7	1.1
Ever used hormone-replacement therapy (HRT)	1.9	2.4	6.0	1.5	-0.7	-1.0	-2.5
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	-0.5	-0.7	-0.7	-0.9
Systolic blood pressure, automated reading	0.4	1.1	2.4	-1.0	-0.6	1.5	0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	-1.0	-1.4	-0.2	-0.7
Angina	0.7	0.9	2.1	-1.1	-0.6	0.3	-1.5
Medication for hormone replacement therapy	0.7	0.8	1.6	0.7	-1.3	0.1	-1.0
Vitamin and mineral supplements	2.0	2.7	3.6	1.8	0.9	1.9	1.9
Supplements: Zinc	0.8	0.8	2.7	-0.5	0.4	-1.6	-0.5
Medication: Co-codamol	0.8	0.9	1.5	0.6	-1.2	0.7	1.2
Medication: Metformin	0.2	0.2	0.7	-0.2	-0.0	-0.9	-0.3
Diabetes (father)	1.0	1.3	4.7	-0.4	0.1	0.6	2.2
Diabetes (mother)	0.6	0.8	1.5	1.2	1.1	-0.3	0.6
Severe depression (siblings)	0.7	0.8	1.4	0.9	0.9	-0.2	1.2
Pack years adult smoking proportion	1.0	1.5	4.2	-1.2	-2.0	-0.4	-0.1
Impedance of leg (right)	0.2	1.2	4.7	0.1	0.0	-0.2	-2.2
Leg fat-free mass (left)	0.5	2.4	7.9	-2.8	-0.8	-0.3	1.0
Trunk fat percentage	0.3	1.2	2.3	-1.5	-1.1	1.0	-0.0
Hand grip strength (right)	0.3	0.8	1.4	0.7	1.1	0.1	1.2
Townsend deprivation index at recruitment	0.6	0.9	2.8	0.0	-1.7	0.4	0.7
Current tobacco smoking	0.3	0.5	1.1	-1.0	-1.0	-0.2	-0.1
Average weekly fortified wine intake	0.4	0.4	1.3	-1.2	0.0	0.4	0.4
Maternal smoking around birth	1.0	1.5	3.2	-1.2	-1.8	-0.3	-1.1
Fed-up feelings	1.7	3.1	5.4	0.8	-2.2	1.3	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	-0.0	-0.2	0.3	-0.4
Relative age voice broke	0.4	0.6	1.1	1.1	-0.1	1.1	-0.2
Taking other prescription medications	1.9	3.0	11.3	3.4	0.0	0.3	0.7
Age when periods started (menarche)	0.4	0.9	2.0	1.4	1.2	0.3	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.4	0.2	-0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.5	-0.7	-0.4	0.5	1.9
Tinnitus: Yes, but not now, but have in the past	4.3	4.6	5.5	2.0	2.2	-2.3	2.0
Qualifications: CSEs or equivalent	0.8	1.1	2.4	-1.1	-0.8	0.5	1.5
Serious illness, injury or assault to yourself	1.2	1.5	3.7	-1.9	-1.0	0.9	-0.6
High blood pressure	0.2	0.6	1.9	0.6	-0.1	-0.4	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.0	-0.0	1.1	-0.6	1.4
Multivitamins +/- minerals	2.0	2.5	6.0	-2.4	-1.2	-1.1	-1.2
Stomach or abdominal pain in last month	1.5	1.9	2.9	1.7	1.7	-1.2	0.7
Supplements: Glucosamine	1.1	1.5	4.4	1.0	2.1	-0.5	0.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	3.4	-1.8	0.7	-0.6	1.2
Medication: Atenolol	1.5	1.8	4.0	-0.2	0.8	-2.0	-1.7
Medication: Levothyroxine sodium	0.3	0.5	0.8	0.8	-0.6	0.2	0.9
Sitting height	0.4	2.7	7.8	-2.8	-1.5	-0.6	-0.6
Chronic bronchitis/emphysema (father)	1.2	1.4	4.4	-0.7	-0.1	0.8	2.1
High blood pressure (mother)	2.3	3.3	5.7	-0.2	2.0	-1.9	2.4
Body mass index (BMI)	0.3	1.5	4.6	-0.7	-0.6	0.7	2.1
Impedance of leg (left)	0.3	1.4	5.3	0.2	0.2	-0.3	-2.3
Leg predicted mass (left)	0.4	2.3	7.5	-2.7	-0.7	-0.3	1.0
Trunk fat mass	0.5	2.1	5.3	-2.3	-1.5	0.9	0.3
Waist circumference	0.4	1.6	3.1	-1.8	-0.9	0.7	1.4
Number of incorrect matches in round	1.5	2.6	4.0	1.3	-1.7	1.3	-2.0
Past tobacco smoking	0.2	0.3	0.5	0.3	0.6	0.5	0.7
Alcohol usually taken with meals	0.4	0.6	1.0	-1.0	0.5	0.4	1.0
Nervous feelings	0.8	1.4	2.2	0.7	-1.5	1.0	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	2.4	-1.2	-1.1	0.4	-1.5
Hearing difficulty/problems with background noise	1.2	1.9	5.7	0.1	0.6	1.3	2.4
Hair/balding pattern: Pattern 2	0.7	1.0	1.9	1.4	1.1	-0.8	0.2
Had menopause	3.0	3.7	9.4	-0.8	-2.2	-0.3	-3.1
Had other major operations	0.2	0.3	0.6	0.8	-0.5	-0.0	-0.4
Forced vital capacity (FVC)	0.2	0.7	2.5	-0.2	1.6	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.5	-0.8	-0.1	0.7	2.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.7	0.6	1.3	-0.9	0.4
Qualifications: None of the above	0.4	0.9	1.5	0.4	-1.2	0.6	-1.2
Financial difficulties in last 2 years	0.4	0.6	1.6	0.1	-0.7	-1.3	0.3
Mouth/teeth dental problems	0.7	1.0	2.7	0.2	1.6	-0.4	1.1
Heart attack	0.1	0.1	0.2	0.3	0.0	-0.5	-0.4
Allergy	0.2	0.5	1.0	-0.7	-0.3	0.5	-1.0
Pain all over the body in last month	1.3	1.4	4.7	-0.6	-0.3	-2.2	-0.6
Diabetes (self-reported)	0.3	0.5	1.1	0.6	0.1	-0.8	1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	-0.5	-0.4	0.8	1.1
Medication: Ramipril	1.8	2.4	4.8	-1.3	-2.2	0.2	-1.7
Medication: Simvastatin	0.8	1.1	2.7	1.6	-0.6	-0.6	-1.1
Fluid intelligence score	0.4	0.8	2.4	-0.2	1.5	-0.1	0.9
Illnesses of siblings	0.7	0.9	1.7	0.1	-0.7	1.2	-1.3
Neuroticism score	0.7	1.5	3.3	0.5	-1.5	-0.4	-1.8
Weight	0.5	2.4	6.2	-2.5	-1.3	0.5	1.2
Impedance of arm (right)	0.1	0.6	1.5	0.4	0.6	0.6	-1.2
Arm fat percentage (right)	0.4	1.6	2.2	-0.9	-1.1	1.5	1.5
Trunk fat-free mass	0.5	2.8	9.2	-3.0	-1.1	-0.3	0.8
Hip circumference	0.5	2.0	3.6	-1.9	-0.9	1.2	1.4
Time employed in main current job	1.7	1.9	2.5	1.4	1.5	1.6	1.1
Alcohol intake versus 10 years previously	0.7	1.1	3.6	1.9	-0.3	-0.0	-0.7
Father’s age at death	0.7	0.9	1.6	-1.1	-0.7	1.2	-0.6
Worrier / anxious feelings	0.1	0.1	0.3	-0.0	-0.3	-0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.1	-1.5	0.2	-0.4	0.5
Falls in the last year	0.9	1.3	4.1	-0.0	0.6	-0.7	2.0
Hair/balding pattern: Pattern 3	0.6	0.9	2.5	-0.4	1.6	-0.9	-0.4
Number of live births	0.7	1.0	2.1	-0.2	-1.5	0.2	-1.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.4	-1.1	1.5	-0.5	0.9
Pulse rate	1.4	2.3	7.5	0.4	-0.4	1.1	-2.7
Happiness	0.6	0.7	1.4	0.3	1.2	-0.4	1.1
Noisy workplace	0.3	0.4	0.7	0.1	-0.8	-0.8	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.9	-0.2	1.7	-1.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.7	0.9	1.3	0.4	1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	1.2	0.1	-0.7	-0.5
Asthma	1.1	2.1	6.5	2.5	0.7	0.6	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.2	1.0	1.8	-1.4	1.2
Medication: Cholesterol lowering	0.3	0.4	1.5	1.2	-0.4	-0.2	-0.2
Depression (self-reported)	0.5	0.5	1.1	1.0	0.4	0.1	1.0
Medication: Lansoprazole	0.2	0.3	0.4	0.2	-0.5	0.6	-0.6
Prospective memory result	3.1	3.9	7.8	-1.4	-2.3	-0.6	-2.8
Lung cancer (father)	0.8	0.9	1.5	-0.7	-0.7	-1.2	-1.0
Illnesses of mother	1.2	1.5	2.8	-1.3	-1.0	0.6	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.8	-1.3	1.0	-0.6	0.6
Pulse wave Arterial Stiffness index	1.9	2.2	4.2	-0.8	-2.0	0.6	-1.9
Impedance of arm (left)	0.3	1.2	3.2	0.7	1.0	0.5	-1.8
Arm fat mass (right)	0.4	1.8	3.2	-1.8	-1.2	1.0	1.3
Trunk predicted mass	0.5	2.8	9.3	-3.0	-1.1	-0.2	0.8
Standing height	0.6	5.8	17.4	-4.2	-1.5	-0.1	-1.9
Length of working week for main job	0.6	0.7	1.3	-1.1	-0.5	0.6	0.9
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.3	-0.8	0.4	0.3
Breastfed as a baby	0.6	0.7	1.7	0.9	-0.5	1.3	-0.1
Tense / ‘highly strung’	0.8	1.3	3.9	0.3	-1.0	-0.3	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.6	-0.6	0.3	-1.6	-1.9
Hair/balding pattern: Pattern 4	1.1	2.7	6.2	-1.1	-2.5	1.8	0.4
Birth weight of first child	0.5	0.9	1.2	-1.0	-0.5	1.0	-1.1
Peak expiratory flow (PEF)	0.4	1.0	1.6	-1.1	0.9	-0.7	-1.2
Pulse wave reflection index	0.6	0.8	1.8	-0.4	-1.3	1.1	0.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.6	-0.3	0.5	-0.2	1.9
Loud music exposure frequency	1.1	1.2	2.3	-1.5	-1.5	0.7	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.7	-0.7	1.3	-0.2	0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.6	-0.8	-1.6	0.5	-0.8
Blood clot in the leg (DVT)	0.4	0.5	1.8	-0.5	-1.3	-0.1	-0.2
Medication: Paracetamol	0.6	1.0	3.1	1.8	0.0	-0.5	0.7
Headache pain in last month	0.4	0.7	1.3	0.7	1.0	-0.4	1.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	-0.4	0.8	-0.3	-0.2
Glaucoma (self-reported)	0.2	0.2	0.5	-0.7	0.2	0.3	0.4
Gout (self-reported)	0.5	0.6	2.0	1.4	0.6	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.9	0.3	-0.9	-0.1	0.3
Medication: Amlodipine	0.8	1.1	2.0	-0.5	-0.9	1.4	1.2
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.3	1.1	-0.3	1.8	0.8
Birth weight	0.2	0.4	0.7	0.5	-0.8	-0.0	-0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.9	-1.2	-1.4	-0.1	-0.4
High blood pressure (siblings)	0.8	1.2	2.1	0.6	1.0	-1.1	1.5
Forced vital capacity (FVC), Best measure	0.2	0.8	2.0	-0.6	1.4	-0.8	-0.2
Body fat percentage	0.3	1.1	1.8	-1.4	-1.1	0.9	0.5
Leg fat percentage (right)	0.2	0.8	1.2	-0.6	-1.0	0.7	1.1
Arm fat-free mass (right)	0.6	2.8	9.5	-3.1	-1.4	-0.3	-0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.0	-0.5	-0.0	-0.8	-1.0
Comparative body size at age 10	0.3	0.9	1.5	-0.2	1.2	-1.2	-0.7
Number of full brothers	0.8	1.0	1.4	0.4	-1.0	1.2	1.1
Worry too long after embarrassment	1.3	2.2	4.6	0.7	-2.1	1.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.7	0.3	0.2	-1.3	-1.9
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	1.1	0.4	-0.3	1.1
Number of children fathered	1.1	1.2	4.5	-0.2	0.4	-0.2	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.1	0.4	-0.8	-0.2
Age at first live birth	1.1	2.0	3.9	-1.1	2.0	-1.7	0.4
Pulse wave peak to peak time	1.8	2.1	4.5	0.6	2.1	-0.5	1.8
Health satisfaction	0.5	0.7	1.7	0.9	-0.1	-1.3	0.3
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.2	-0.5	0.4	-0.2
Qualifications: College or University degree	0.6	1.9	4.8	0.3	2.2	-1.6	0.4
Eye problems/disorders: None of the above	0.5	0.6	1.4	-0.4	-1.2	0.0	-0.9
Mouth/teeth dental problems: Loose teeth	2.4	2.9	7.6	-0.3	-2.8	1.0	-1.7
Emphysema/chronic bronchitis	0.4	0.5	1.0	0.7	-0.5	-1.0	-0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	3.0	-1.7	-0.7	0.3	-0.6
Neck or shoulder pain in last month	1.1	1.5	4.6	2.1	0.9	-0.7	0.1
Medication: Blood pressure	0.2	0.4	1.2	-0.1	-1.1	0.5	0.0
Angina (self-reported)	0.6	0.8	1.9	-1.0	-0.5	0.5	-1.4
Migraine (self-reported)	0.3	0.4	0.8	0.9	0.3	-0.9	0.3
Medication: Ibuprofen	0.8	1.0	2.5	0.5	1.6	-1.0	0.3
Medication: Allopurinol	0.6	0.8	1.8	1.3	-0.2	-0.2	-1.2
Medication: Omeprazole	1.8	2.2	3.5	1.6	1.5	-0.6	1.9
Medication: Seretide 50 evohaler	2.3	2.6	3.7	1.8	1.9	-0.4	1.8
Mean time to correctly identify matches	1.6	3.1	7.2	-0.1	-2.1	2.7	-0.9
Heart disease (mother)	1.2	1.5	2.1	1.4	1.5	-0.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.3	1.5	1.3	-1.4	-0.2
Whole body fat mass	0.6	2.3	5.0	-2.2	-1.8	0.8	0.6
Leg fat mass (right)	0.4	1.6	2.9	-1.7	-1.5	0.5	1.2
Arm predicted mass (right)	0.5	2.5	8.2	-2.9	-1.3	-0.2	-0.2
Pulse rate, automated reading	0.5	1.5	2.6	0.6	1.6	0.7	-1.5
Alcohol intake frequency.	0.5	1.2	4.6	0.1	-2.1	-0.5	0.3
Comparative height size at age 10	0.7	3.7	8.9	-3.0	-1.3	-0.5	-1.9
Number of full sisters	0.5	0.6	1.5	-0.9	-1.2	0.1	-0.4
Suffer from ‘nerves’	0.9	1.4	3.3	-0.4	-1.8	1.2	-0.9
Overall health rating	0.5	1.1	3.0	-1.0	-1.7	0.5	0.2
Chest pain or discomfort	0.6	0.8	1.8	-0.4	0.5	-1.4	1.0
Had major operations	0.1	0.2	0.4	-0.5	-0.2	0.1	-0.7
Age at last live birth	1.0	1.4	3.0	-0.5	1.3	-1.7	0.9
Family relationship satisfaction	1.4	1.7	3.3	0.2	1.4	-1.8	1.3
Leg pain on walking	1.0	1.2	2.1	0.8	-1.4	1.4	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.1	-1.1	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.6	-0.0	-0.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.4	0.6	-0.7	0.3	-0.6
Medication: Aspirin	0.4	0.5	1.8	1.3	0.4	-0.1	0.2
Supplements: Vitamin C	2.7	3.2	11.2	-1.0	0.6	-3.3	0.4
Knee pain experienced in last month	0.2	0.2	0.5	0.7	0.7	0.2	0.1
Hypertension (Self-reported)	0.2	0.6	1.3	1.1	-0.0	-0.0	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.4	1.2	-0.5	1.1	-1.1
Illnesses of father: Heart disease	0.1	0.2	0.3	0.3	-0.4	-0.6	-0.5
Illnesses of siblings: Diabetes	1.1	1.3	3.5	1.3	0.5	-1.9	0.0
Smoking status: Previous	0.1	0.2	0.6	-0.0	-0.2	-0.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.4	-1.2	1.4	-1.5	0.3
Whole body fat-free mass	0.5	2.7	8.9	-3.0	-1.1	-0.3	0.7
Leg fat-free mass (right)	0.4	2.1	6.8	-2.6	-0.5	-0.4	1.0
Arm fat percentage (left)	0.2	0.8	1.1	-0.7	-0.8	1.0	1.0
Average weekly red wine intake	0.7	1.1	3.3	-0.1	0.7	-0.7	-1.8
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.8	0.3	0.6	-0.6	1.3
Mood swings	0.9	1.6	3.1	0.2	-1.7	0.4	-1.8
Loneliness, isolation	0.2	0.3	0.5	-0.5	-0.7	-0.5	-0.7
Long-standing illness, disability or infirmity	1.0	1.5	4.2	1.2	-2.0	0.5	-0.1
Ever had bowel cancer screening	0.3	0.4	0.8	-0.9	0.2	-0.8	-0.3
Diabetes diagnosed by doctor	0.2	0.3	1.3	-0.1	-1.1	-0.3	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.3	-0.1	1.5	-1.2	0.8
Friendships satisfaction	1.2	1.5	2.8	0.9	1.7	0.3	1.5
Qualifications: nursing, teaching	0.8	1.2	2.0	-1.3	1.4	-0.4	1.1
Commuting to job workplace: Walk	1.5	1.6	3.1	1.4	1.8	-1.0	0.8
Eye problems/disorders: Cataract	0.5	0.5	1.1	0.6	0.7	-1.0	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.1	0.5	0.4	0.0
Medication for cholesterol	1.0	1.6	4.1	-2.0	0.8	1.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.7	-1.6	-0.1	-1.4	0.0
Back pain experienced in last month	0.7	1.0	2.9	-1.7	-1.0	0.0	-0.4
Mineral and other dietary supplements	0.1	0.2	0.4	-0.6	0.0	0.2	0.4
Breast cancer (self-reported)	0.0	0.1	0.2	-0.4	-0.0	0.2	-0.0
Asthma (self-reported)	1.0	2.0	6.4	2.5	0.8	0.5	0.8
Osteoporosis (self-reported)	0.6	0.8	1.4	0.7	-0.1	-1.2	-1.1
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.6	0.0	-0.1	-0.6
Medication: Aspirin	0.5	0.6	2.2	1.5	0.1	0.4	0.4
Medication: Gliclazide	0.5	0.5	2.0	-0.3	-0.2	-1.4	0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	0.2	-0.8	-0.4	-0.9
Smoking status: Current	0.3	0.5	0.9	-0.9	-1.0	-0.4	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.0	0.2	1.4	-2.2	-0.2
Whole body water mass	0.5	2.8	9.5	-3.1	-1.1	-0.2	0.7
Leg predicted mass (right)	0.4	2.1	6.9	-2.6	-0.5	-0.4	1.0
Arm fat mass (left)	0.4	1.6	2.8	-1.7	-1.3	1.1	1.0
Number of self-reported non-cancer illnesses	0.6	1.1	2.7	0.7	-1.6	0.9	0.5
Average weekly champagne plus white wine intake	0.5	0.6	1.7	-1.3	0.4	0.8	0.3
Miserableness	0.8	1.3	4.4	-0.5	-0.6	-0.6	-2.1
Guilty feelings	1.1	1.7	4.0	-0.1	-1.5	2.0	-0.7
Wears glasses or contact lenses	1.2	1.4	2.7	-0.9	-1.6	1.0	-1.0
Ever taken oral contraceptive pill	2.1	2.3	5.2	0.8	1.7	-2.3	0.8
Hearing aid user	0.6	0.7	2.7	0.0	0.0	-1.6	0.1
Mother’s age at death	0.6	0.7	1.4	-0.4	-1.0	0.5	-1.2
Financial situation satisfaction	0.6	0.7	1.9	-0.8	-0.5	-1.4	-0.0
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	0.2	0.3	-0.7	0.6
Commuting to job workplace: Public transport	0.2	0.3	0.7	-0.2	-0.6	-0.1	-0.8
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	-0.0	0.6	0.5	-0.2
Medication: Blood pressure	0.3	0.5	0.9	0.6	-0.7	-1.0	0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.1	-0.4	-0.9	1.4	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.8	-0.0	-1.1	1.4	-0.9
High cholesterol (Self-reported)	0.8	1.5	4.4	2.1	0.9	-0.6	-0.3
Medication: Bendroflumethiazide	0.3	0.5	0.9	0.9	-0.3	0.2	0.9
Medication: Paracetamol	0.6	0.9	3.1	1.8	0.5	-0.2	0.6
Medication: Lisinopril	0.7	0.9	1.2	0.5	1.1	-1.0	1.0
Medication: Atorvastatin	0.0	0.1	0.1	0.0	0.1	-0.3	0.4
Illnesses of father: High blood pressure	2.4	3.0	7.4	0.8	2.7	-1.5	1.3
Alcohol drinker status: Never	0.3	0.4	1.2	-0.5	-0.2	-1.1	0.3
Ever smoked	0.2	0.4	1.3	-0.7	-0.0	-1.1	-0.1
Basal metabolic rate	0.5	2.8	9.0	-3.0	-1.0	-0.2	1.0
Leg fat percentage (left)	0.2	0.8	1.6	-0.6	-0.9	0.6	1.3
Arm fat-free mass (left)	0.6	2.8	9.0	-3.0	-1.5	0.2	0.4
Number of operations (self-reported)	0.2	0.2	0.7	-0.4	-0.8	0.0	-0.4
Average weekly beer plus cider intake	1.4	2.0	5.8	1.4	0.2	0.5	2.4
Irritability	1.0	1.6	3.5	1.3	0.9	-1.9	0.6
Risk taking	0.0	0.1	0.1	-0.3	0.1	-0.2	-0.3
Ever had prostate specific antigen (PSA) test	2.6	3.0	4.6	-2.1	-2.1	1.4	-1.0
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.4	0.1	-0.9	0.4
Age started oral contraceptive pill	0.4	0.6	0.8	0.9	-0.7	0.9	0.4
Diastolic blood pressure, automated reading	0.3	1.0	2.2	-0.4	0.5	1.2	1.5
Ever depressed for a whole week	0.9	1.1	2.4	0.2	1.6	-1.4	-0.5
Unable to work because of sickness or disability	0.4	0.5	1.7	-0.5	-1.3	-0.4	0.3
Commuting to job workplace: Cycle	0.4	0.5	1.7	0.4	-0.2	0.3	-1.3
Myopia	0.7	1.1	3.7	-1.9	-0.7	-0.3	-0.0
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.3	-1.3	-0.0	0.6	-1.5
Cholesterol lowering medication	0.6	0.9	1.9	1.4	0.1	-1.2	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.6	1.9	1.8	-1.2	1.0
Pain experienced in last month	0.2	0.3	1.2	-0.2	0.0	0.0	-1.1
Supplements: Calcium	0.8	0.9	3.2	0.6	0.2	-1.8	0.1
Basal cell carcinoma (self-reported)	1.2	1.4	3.0	-1.7	-1.2	1.0	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.1	-0.4	-0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.9	-0.3	-1.4	0.0	-0.3
Heart disease (siblings)	0.7	0.9	1.5	-1.2	-0.3	-1.1	-0.9
Alcohol drinker status: Previous	0.7	0.7	1.9	0.9	0.5	-1.4	0.2
Pack years of smoking	1.2	1.7	4.9	-1.2	-2.2	-0.4	-0.5
Impedance of whole body	0.3	1.3	4.4	0.5	0.7	0.0	-2.1
Leg fat mass (left)	0.4	1.5	2.8	-1.7	-1.4	0.4	1.1
Arm predicted mass (left)	0.6	2.9	9.4	-3.1	-1.4	-0.1	0.5