Hub : Genes

ZNF587B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0628 0.0288 0.0037 0.009 NA 0.008 NA 0.001 4.1e-02 NA 0.05400 NA 2.3e-01
2 GTEx Skin Sun Exposed Lower leg 0.1100 0.0440 0.0027 0.008 NA 0.000 NA 0.013 6.7e-02 NA 0.33000 NA 2.5e-02
3 GTEx Testis 0.1290 0.0570 0.0085 0.075 NA 0.074 NA 0.042 3.3e-04 NA 0.00034 NA 5.8e-03
4 GTEx Whole Blood 0.0770 0.0370 0.0047 0.069 NA 0.022 NA 0.059 5.5e-07 NA 0.00360 NA 4.0e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.9 1.4 0.6 1.2 -1.0 0.8
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 0.6 0.1 -0.1 0.8
Depressed Affect (Nagel 2018) 0.8 1.6 3.5 -0.4 -1.5 0.9 -1.9
Depression (Nagel 2018) 0.1 0.2 0.2 -0.5 0.5 0.5 0.0
Intelligence (Savage-Jansen 2018) 0.6 1.7 5.2 -0.9 0.8 -0.4 2.3
Neuroticism (Nagel 2018) 0.2 0.6 1.2 0.6 -0.5 0.6 -1.1
Schizophrenia (2018) 0.2 0.4 0.8 0.3 -0.8 0.9 0.4
Schizophrenia vs Biploar Disorder 0.6 0.8 1.4 0.2 0.9 -1.2 1.0
Worry (Nagel 2018) 0.3 0.7 2.4 -0.2 -0.5 0.0 -1.5
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 -0.3 -0.5 0.6 -0.3
Alzheimer’s Disease (in father) 1.3 1.5 2.8 -1.0 -1.7 1.4 -0.5
Alzheimer’s Disease (including proxy) 0.6 0.9 1.3 -1.2 -1.0 1.1 -0.5
Crohns Disease (2017) 0.1 0.1 0.3 -0.5 -0.5 0.2 0.1
Irritable Bowel Disease (IBD) 0.2 0.6 1.5 -1.2 -0.8 0.4 -0.0
Ulcerative Colitis (UC) 0.5 0.9 2.6 -1.6 -0.7 0.4 0.4
Major Depression (MDD) 1.1 1.3 4.2 0.2 1.0 -2.1 -0.3
Reaction Time 0.9 1.7 4.9 0.1 -1.3 2.2 0.1
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.2 -1.1 0.3 -0.7 0.1
Breast Cancer 1.2 2.9 3.9 1.9 1.7 -2.0 1.0
Ovarian Cancer 1.2 1.6 3.7 -0.9 -1.3 1.9 -0.5
Prostate Cancer 2.6 3.6 5.9 2.4 2.3 0.4 1.8
Age at First Birth 0.2 0.3 0.8 0.4 0.9 -0.0 0.5
Bipolar Disorder (2011) 0.0 0.0 0.1 0.2 -0.1 -0.1 0.2
Body Mass Index (BMI) (2010) 2.0 2.7 9.1 0.3 1.1 -3.0 0.6
Coronary Artery Disease (CAD) 0.4 0.5 1.5 0.2 1.2 -0.3 0.4
Crohns Disease (2012) 0.4 0.6 1.8 -0.4 -1.4 -0.3 -0.5
Mean Putamen Volume 0.2 0.2 0.5 -0.7 0.1 -0.4 -0.3
Fasting Glucose 1.2 1.4 2.2 1.3 1.3 -1.5 0.1
HbA1C 3.3 3.7 7.4 1.6 2.7 -1.4 1.6
HDL Cholesterol 0.1 0.2 0.4 0.5 0.3 0.6 0.3
LDL Cholesterol 0.3 0.4 0.9 -0.3 -0.5 -0.5 -1.0
Lupus 0.6 0.9 2.7 1.6 0.3 0.3 0.8
Neuroticism (2016) 1.5 2.2 6.0 0.6 -1.5 -0.6 -2.4
Primary Biliary Cirrhosis 0.3 0.4 1.0 -1.0 -0.4 0.2 0.5
Rheumatoid Arthritis 1.7 2.3 5.6 2.4 1.2 0.3 1.4
Schizophrenia (2014) 0.3 0.6 1.0 0.7 0.9 -1.0 0.4
Triglycerides 0.5 0.8 2.4 -0.7 -0.1 -1.6 -0.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 -0.0 0.5 -0.5 -0.2
Ulcerative Colitis 0.2 0.2 0.7 0.3 -0.8 0.4 -0.1
Blood Eosinophil Count 1.3 10.3 23.1 2.5 3.4 0.1 4.8
Blood Platelet Count 0.5 5.4 12.0 2.7 3.5 -0.1 1.6
Blood Red Count 0.1 1.1 2.8 1.7 -0.4 -0.7 -1.0
Blood White Count 0.6 4.7 9.7 2.5 1.5 0.8 3.1
Heel T-Score 0.3 2.7 6.7 -0.6 0.8 1.8 2.6
BMI 0.4 2.1 5.4 -1.7 -0.1 -0.4 2.3
Height 0.7 13.3 32.3 -5.7 -3.2 1.0 -3.1
Waist Hip Ratio (WHR) 0.4 1.7 4.7 0.7 2.2 -1.1 0.5
Systolic Blood Pressure 0.6 2.8 7.5 0.2 -0.9 2.7 1.7
Smoking Status 0.6 1.6 2.6 -1.3 -1.4 -0.1 -1.6
Allergy or Eczema 0.9 2.3 4.0 0.4 2.0 -1.1 2.0
Cardiovascular Disease 0.3 1.0 2.5 1.6 0.3 -0.0 1.3
Hypothyroidism (self reported) 0.1 0.3 0.6 0.8 -0.6 -0.3 0.3
Respiratory disease 1.2 2.8 6.0 2.5 1.8 0.7 1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.6 -0.3 -0.8 -0.4 0.5
Lung FEV1/FVC ratio 0.6 2.9 9.4 -3.1 -0.3 -0.9 1.2
Lung FVC 0.2 0.9 2.3 1.0 1.5 -0.2 0.4
Neuroticism 0.9 2.1 4.4 -0.2 -2.1 1.1 -1.7
Chronotype (morning person) 1.3 3.0 9.0 1.0 3.0 -1.4 -0.1
Hair Pigment 0.1 3.0 9.2 3.0 1.4 -0.7 -0.4
Tanning 0.3 3.9 5.6 -2.4 -2.2 1.4 -1.8
Hand grip strength (left) 0.1 0.2 0.4 0.5 0.6 0.2 0.6
Number of treatments/medications taken 1.6 2.9 11.4 3.4 0.3 0.0 0.2
Average weekly spirits intake 0.4 0.5 1.3 0.0 0.7 0.6 1.1
Sensitivity / hurt feelings 0.7 1.1 2.1 1.1 0.3 -1.0 -1.5
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.1 -0.7 -0.5 0.2 -1.0
Hearing difficulty/problems: Yes 1.8 2.8 9.3 0.1 1.0 0.9 3.0
Relative age of first facial hair 0.2 0.4 1.2 -0.0 -0.5 0.5 1.1
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.6 -0.4 -1.3 0.7 1.1
Ever used hormone-replacement therapy (HRT) 1.9 2.4 6.0 1.5 -0.7 -1.0 -2.5
Ever had hysterectomy (womb removed) 0.4 0.5 0.8 -0.5 -0.7 -0.7 -0.9
Systolic blood pressure, automated reading 0.4 1.1 2.4 -1.0 -0.6 1.5 0.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.0 -1.0 -1.4 -0.2 -0.7
Angina 0.7 0.9 2.1 -1.1 -0.6 0.3 -1.5
Medication for hormone replacement therapy 0.7 0.8 1.6 0.7 -1.3 0.1 -1.0
Vitamin and mineral supplements 2.0 2.7 3.6 1.8 0.9 1.9 1.9
Supplements: Zinc 0.8 0.8 2.7 -0.5 0.4 -1.6 -0.5
Medication: Co-codamol 0.8 0.9 1.5 0.6 -1.2 0.7 1.2
Medication: Metformin 0.2 0.2 0.7 -0.2 -0.0 -0.9 -0.3
Diabetes (father) 1.0 1.3 4.7 -0.4 0.1 0.6 2.2
Diabetes (mother) 0.6 0.8 1.5 1.2 1.1 -0.3 0.6
Severe depression (siblings) 0.7 0.8 1.4 0.9 0.9 -0.2 1.2
Pack years adult smoking proportion 1.0 1.5 4.2 -1.2 -2.0 -0.4 -0.1
Impedance of leg (right) 0.2 1.2 4.7 0.1 0.0 -0.2 -2.2
Leg fat-free mass (left) 0.5 2.4 7.9 -2.8 -0.8 -0.3 1.0
Trunk fat percentage 0.3 1.2 2.3 -1.5 -1.1 1.0 -0.0
Hand grip strength (right) 0.3 0.8 1.4 0.7 1.1 0.1 1.2
Townsend deprivation index at recruitment 0.6 0.9 2.8 0.0 -1.7 0.4 0.7
Current tobacco smoking 0.3 0.5 1.1 -1.0 -1.0 -0.2 -0.1
Average weekly fortified wine intake 0.4 0.4 1.3 -1.2 0.0 0.4 0.4
Maternal smoking around birth 1.0 1.5 3.2 -1.2 -1.8 -0.3 -1.1
Fed-up feelings 1.7 3.1 5.4 0.8 -2.2 1.3 -2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.1 -0.0 -0.2 0.3 -0.4
Relative age voice broke 0.4 0.6 1.1 1.1 -0.1 1.1 -0.2
Taking other prescription medications 1.9 3.0 11.3 3.4 0.0 0.3 0.7
Age when periods started (menarche) 0.4 0.9 2.0 1.4 1.2 0.3 -0.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.1 0.4 0.2 -0.3 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.5 -0.7 -0.4 0.5 1.9
Tinnitus: Yes, but not now, but have in the past 4.3 4.6 5.5 2.0 2.2 -2.3 2.0
Qualifications: CSEs or equivalent 0.8 1.1 2.4 -1.1 -0.8 0.5 1.5
Serious illness, injury or assault to yourself 1.2 1.5 3.7 -1.9 -1.0 0.9 -0.6
High blood pressure 0.2 0.6 1.9 0.6 -0.1 -0.4 1.4
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.0 -0.0 1.1 -0.6 1.4
Multivitamins +/- minerals 2.0 2.5 6.0 -2.4 -1.2 -1.1 -1.2
Stomach or abdominal pain in last month 1.5 1.9 2.9 1.7 1.7 -1.2 0.7
Supplements: Glucosamine 1.1 1.5 4.4 1.0 2.1 -0.5 0.5
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 3.4 -1.8 0.7 -0.6 1.2
Medication: Atenolol 1.5 1.8 4.0 -0.2 0.8 -2.0 -1.7
Medication: Levothyroxine sodium 0.3 0.5 0.8 0.8 -0.6 0.2 0.9
Sitting height 0.4 2.7 7.8 -2.8 -1.5 -0.6 -0.6
Chronic bronchitis/emphysema (father) 1.2 1.4 4.4 -0.7 -0.1 0.8 2.1
High blood pressure (mother) 2.3 3.3 5.7 -0.2 2.0 -1.9 2.4
Body mass index (BMI) 0.3 1.5 4.6 -0.7 -0.6 0.7 2.1
Impedance of leg (left) 0.3 1.4 5.3 0.2 0.2 -0.3 -2.3
Leg predicted mass (left) 0.4 2.3 7.5 -2.7 -0.7 -0.3 1.0
Trunk fat mass 0.5 2.1 5.3 -2.3 -1.5 0.9 0.3
Waist circumference 0.4 1.6 3.1 -1.8 -0.9 0.7 1.4
Number of incorrect matches in round 1.5 2.6 4.0 1.3 -1.7 1.3 -2.0
Past tobacco smoking 0.2 0.3 0.5 0.3 0.6 0.5 0.7
Alcohol usually taken with meals 0.4 0.6 1.0 -1.0 0.5 0.4 1.0
Nervous feelings 0.8 1.4 2.2 0.7 -1.5 1.0 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.3 2.4 -1.2 -1.1 0.4 -1.5
Hearing difficulty/problems with background noise 1.2 1.9 5.7 0.1 0.6 1.3 2.4
Hair/balding pattern: Pattern 2 0.7 1.0 1.9 1.4 1.1 -0.8 0.2
Had menopause 3.0 3.7 9.4 -0.8 -2.2 -0.3 -3.1
Had other major operations 0.2 0.3 0.6 0.8 -0.5 -0.0 -0.4
Forced vital capacity (FVC) 0.2 0.7 2.5 -0.2 1.6 -0.6 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 4.5 -0.8 -0.1 0.7 2.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 1.7 0.6 1.3 -0.9 0.4
Qualifications: None of the above 0.4 0.9 1.5 0.4 -1.2 0.6 -1.2
Financial difficulties in last 2 years 0.4 0.6 1.6 0.1 -0.7 -1.3 0.3
Mouth/teeth dental problems 0.7 1.0 2.7 0.2 1.6 -0.4 1.1
Heart attack 0.1 0.1 0.2 0.3 0.0 -0.5 -0.4
Allergy 0.2 0.5 1.0 -0.7 -0.3 0.5 -1.0
Pain all over the body in last month 1.3 1.4 4.7 -0.6 -0.3 -2.2 -0.6
Diabetes (self-reported) 0.3 0.5 1.1 0.6 0.1 -0.8 1.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.2 -0.5 -0.4 0.8 1.1
Medication: Ramipril 1.8 2.4 4.8 -1.3 -2.2 0.2 -1.7
Medication: Simvastatin 0.8 1.1 2.7 1.6 -0.6 -0.6 -1.1
Fluid intelligence score 0.4 0.8 2.4 -0.2 1.5 -0.1 0.9
Illnesses of siblings 0.7 0.9 1.7 0.1 -0.7 1.2 -1.3
Neuroticism score 0.7 1.5 3.3 0.5 -1.5 -0.4 -1.8
Weight 0.5 2.4 6.2 -2.5 -1.3 0.5 1.2
Impedance of arm (right) 0.1 0.6 1.5 0.4 0.6 0.6 -1.2
Arm fat percentage (right) 0.4 1.6 2.2 -0.9 -1.1 1.5 1.5
Trunk fat-free mass 0.5 2.8 9.2 -3.0 -1.1 -0.3 0.8
Hip circumference 0.5 2.0 3.6 -1.9 -0.9 1.2 1.4
Time employed in main current job 1.7 1.9 2.5 1.4 1.5 1.6 1.1
Alcohol intake versus 10 years previously 0.7 1.1 3.6 1.9 -0.3 -0.0 -0.7
Father’s age at death 0.7 0.9 1.6 -1.1 -0.7 1.2 -0.6
Worrier / anxious feelings 0.1 0.1 0.3 -0.0 -0.3 -0.5 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.1 -1.5 0.2 -0.4 0.5
Falls in the last year 0.9 1.3 4.1 -0.0 0.6 -0.7 2.0
Hair/balding pattern: Pattern 3 0.6 0.9 2.5 -0.4 1.6 -0.9 -0.4
Number of live births 0.7 1.0 2.1 -0.2 -1.5 0.2 -1.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 2.4 -1.1 1.5 -0.5 0.9
Pulse rate 1.4 2.3 7.5 0.4 -0.4 1.1 -2.7
Happiness 0.6 0.7 1.4 0.3 1.2 -0.4 1.1
Noisy workplace 0.3 0.4 0.7 0.1 -0.8 -0.8 -0.5
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.9 -0.2 1.7 -1.2 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.7 0.9 1.3 0.4 1.0
Mouth/teeth dental problems: Dentures 0.3 0.5 1.4 1.2 0.1 -0.7 -0.5
Asthma 1.1 2.1 6.5 2.5 0.7 0.6 1.1
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 3.2 1.0 1.8 -1.4 1.2
Medication: Cholesterol lowering 0.3 0.4 1.5 1.2 -0.4 -0.2 -0.2
Depression (self-reported) 0.5 0.5 1.1 1.0 0.4 0.1 1.0
Medication: Lansoprazole 0.2 0.3 0.4 0.2 -0.5 0.6 -0.6
Prospective memory result 3.1 3.9 7.8 -1.4 -2.3 -0.6 -2.8
Lung cancer (father) 0.8 0.9 1.5 -0.7 -0.7 -1.2 -1.0
Illnesses of mother 1.2 1.5 2.8 -1.3 -1.0 0.6 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.8 -1.3 1.0 -0.6 0.6
Pulse wave Arterial Stiffness index 1.9 2.2 4.2 -0.8 -2.0 0.6 -1.9
Impedance of arm (left) 0.3 1.2 3.2 0.7 1.0 0.5 -1.8
Arm fat mass (right) 0.4 1.8 3.2 -1.8 -1.2 1.0 1.3
Trunk predicted mass 0.5 2.8 9.3 -3.0 -1.1 -0.2 0.8
Standing height 0.6 5.8 17.4 -4.2 -1.5 -0.1 -1.9
Length of working week for main job 0.6 0.7 1.3 -1.1 -0.5 0.6 0.9
Exposure to tobacco smoke at home 0.2 0.2 0.6 -0.3 -0.8 0.4 0.3
Breastfed as a baby 0.6 0.7 1.7 0.9 -0.5 1.3 -0.1
Tense / ‘highly strung’ 0.8 1.3 3.9 0.3 -1.0 -0.3 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 3.6 -0.6 0.3 -1.6 -1.9
Hair/balding pattern: Pattern 4 1.1 2.7 6.2 -1.1 -2.5 1.8 0.4
Birth weight of first child 0.5 0.9 1.2 -1.0 -0.5 1.0 -1.1
Peak expiratory flow (PEF) 0.4 1.0 1.6 -1.1 0.9 -0.7 -1.2
Pulse wave reflection index 0.6 0.8 1.8 -0.4 -1.3 1.1 0.1
Ever highly irritable/argumentative for 2 days 0.8 1.0 3.6 -0.3 0.5 -0.2 1.9
Loud music exposure frequency 1.1 1.2 2.3 -1.5 -1.5 0.7 0.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.7 -0.7 1.3 -0.2 0.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.6 -0.8 -1.6 0.5 -0.8
Blood clot in the leg (DVT) 0.4 0.5 1.8 -0.5 -1.3 -0.1 -0.2
Medication: Paracetamol 0.6 1.0 3.1 1.8 0.0 -0.5 0.7
Headache pain in last month 0.4 0.7 1.3 0.7 1.0 -0.4 1.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.7 -0.4 0.8 -0.3 -0.2
Glaucoma (self-reported) 0.2 0.2 0.5 -0.7 0.2 0.3 0.4
Gout (self-reported) 0.5 0.6 2.0 1.4 0.6 0.3 0.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.9 0.3 -0.9 -0.1 0.3
Medication: Amlodipine 0.8 1.1 2.0 -0.5 -0.9 1.4 1.2
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.3 1.1 -0.3 1.8 0.8
Birth weight 0.2 0.4 0.7 0.5 -0.8 -0.0 -0.8
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.9 -1.2 -1.4 -0.1 -0.4
High blood pressure (siblings) 0.8 1.2 2.1 0.6 1.0 -1.1 1.5
Forced vital capacity (FVC), Best measure 0.2 0.8 2.0 -0.6 1.4 -0.8 -0.2
Body fat percentage 0.3 1.1 1.8 -1.4 -1.1 0.9 0.5
Leg fat percentage (right) 0.2 0.8 1.2 -0.6 -1.0 0.7 1.1
Arm fat-free mass (right) 0.6 2.8 9.5 -3.1 -1.4 -0.3 -0.1
Exposure to tobacco smoke outside home 0.4 0.5 1.0 -0.5 -0.0 -0.8 -1.0
Comparative body size at age 10 0.3 0.9 1.5 -0.2 1.2 -1.2 -0.7
Number of full brothers 0.8 1.0 1.4 0.4 -1.0 1.2 1.1
Worry too long after embarrassment 1.3 2.2 4.6 0.7 -2.1 1.6 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 3.7 0.3 0.2 -1.3 -1.9
Wheeze or whistling in the chest in last year 0.4 0.7 1.3 1.1 0.4 -0.3 1.1
Number of children fathered 1.1 1.2 4.5 -0.2 0.4 -0.2 2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.6 -0.1 0.4 -0.8 -0.2
Age at first live birth 1.1 2.0 3.9 -1.1 2.0 -1.7 0.4
Pulse wave peak to peak time 1.8 2.1 4.5 0.6 2.1 -0.5 1.8
Health satisfaction 0.5 0.7 1.7 0.9 -0.1 -1.3 0.3
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.2 -0.5 0.4 -0.2
Qualifications: College or University degree 0.6 1.9 4.8 0.3 2.2 -1.6 0.4
Eye problems/disorders: None of the above 0.5 0.6 1.4 -0.4 -1.2 0.0 -0.9
Mouth/teeth dental problems: Loose teeth 2.4 2.9 7.6 -0.3 -2.8 1.0 -1.7
Emphysema/chronic bronchitis 0.4 0.5 1.0 0.7 -0.5 -1.0 -0.6
Medication for pain relief, constipation, heartburn 0.6 1.0 3.0 -1.7 -0.7 0.3 -0.6
Neck or shoulder pain in last month 1.1 1.5 4.6 2.1 0.9 -0.7 0.1
Medication: Blood pressure 0.2 0.4 1.2 -0.1 -1.1 0.5 0.0
Angina (self-reported) 0.6 0.8 1.9 -1.0 -0.5 0.5 -1.4
Migraine (self-reported) 0.3 0.4 0.8 0.9 0.3 -0.9 0.3
Medication: Ibuprofen 0.8 1.0 2.5 0.5 1.6 -1.0 0.3
Medication: Allopurinol 0.6 0.8 1.8 1.3 -0.2 -0.2 -1.2
Medication: Omeprazole 1.8 2.2 3.5 1.6 1.5 -0.6 1.9
Medication: Seretide 50 evohaler 2.3 2.6 3.7 1.8 1.9 -0.4 1.8
Mean time to correctly identify matches 1.6 3.1 7.2 -0.1 -2.1 2.7 -0.9
Heart disease (mother) 1.2 1.5 2.1 1.4 1.5 -0.5 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 2.3 1.5 1.3 -1.4 -0.2
Whole body fat mass 0.6 2.3 5.0 -2.2 -1.8 0.8 0.6
Leg fat mass (right) 0.4 1.6 2.9 -1.7 -1.5 0.5 1.2
Arm predicted mass (right) 0.5 2.5 8.2 -2.9 -1.3 -0.2 -0.2
Pulse rate, automated reading 0.5 1.5 2.6 0.6 1.6 0.7 -1.5
Alcohol intake frequency. 0.5 1.2 4.6 0.1 -2.1 -0.5 0.3
Comparative height size at age 10 0.7 3.7 8.9 -3.0 -1.3 -0.5 -1.9
Number of full sisters 0.5 0.6 1.5 -0.9 -1.2 0.1 -0.4
Suffer from ‘nerves’ 0.9 1.4 3.3 -0.4 -1.8 1.2 -0.9
Overall health rating 0.5 1.1 3.0 -1.0 -1.7 0.5 0.2
Chest pain or discomfort 0.6 0.8 1.8 -0.4 0.5 -1.4 1.0
Had major operations 0.1 0.2 0.4 -0.5 -0.2 0.1 -0.7
Age at last live birth 1.0 1.4 3.0 -0.5 1.3 -1.7 0.9
Family relationship satisfaction 1.4 1.7 3.3 0.2 1.4 -1.8 1.3
Leg pain on walking 1.0 1.2 2.1 0.8 -1.4 1.4 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.3 0.1 -1.1 0.1 0.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.6 -0.0 -0.5 -0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.4 0.6 -0.7 0.3 -0.6
Medication: Aspirin 0.4 0.5 1.8 1.3 0.4 -0.1 0.2
Supplements: Vitamin C 2.7 3.2 11.2 -1.0 0.6 -3.3 0.4
Knee pain experienced in last month 0.2 0.2 0.5 0.7 0.7 0.2 0.1
Hypertension (Self-reported) 0.2 0.6 1.3 1.1 -0.0 -0.0 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 1.4 1.2 -0.5 1.1 -1.1
Illnesses of father: Heart disease 0.1 0.2 0.3 0.3 -0.4 -0.6 -0.5
Illnesses of siblings: Diabetes 1.1 1.3 3.5 1.3 0.5 -1.9 0.0
Smoking status: Previous 0.1 0.2 0.6 -0.0 -0.2 -0.0 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 2.4 -1.2 1.4 -1.5 0.3
Whole body fat-free mass 0.5 2.7 8.9 -3.0 -1.1 -0.3 0.7
Leg fat-free mass (right) 0.4 2.1 6.8 -2.6 -0.5 -0.4 1.0
Arm fat percentage (left) 0.2 0.8 1.1 -0.7 -0.8 1.0 1.0
Average weekly red wine intake 0.7 1.1 3.3 -0.1 0.7 -0.7 -1.8
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.8 0.3 0.6 -0.6 1.3
Mood swings 0.9 1.6 3.1 0.2 -1.7 0.4 -1.8
Loneliness, isolation 0.2 0.3 0.5 -0.5 -0.7 -0.5 -0.7
Long-standing illness, disability or infirmity 1.0 1.5 4.2 1.2 -2.0 0.5 -0.1
Ever had bowel cancer screening 0.3 0.4 0.8 -0.9 0.2 -0.8 -0.3
Diabetes diagnosed by doctor 0.2 0.3 1.3 -0.1 -1.1 -0.3 0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.3 -0.1 1.5 -1.2 0.8
Friendships satisfaction 1.2 1.5 2.8 0.9 1.7 0.3 1.5
Qualifications: nursing, teaching 0.8 1.2 2.0 -1.3 1.4 -0.4 1.1
Commuting to job workplace: Walk 1.5 1.6 3.1 1.4 1.8 -1.0 0.8
Eye problems/disorders: Cataract 0.5 0.5 1.1 0.6 0.7 -1.0 0.4
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 0.1 0.5 0.4 0.0
Medication for cholesterol 1.0 1.6 4.1 -2.0 0.8 1.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.7 -1.6 -0.1 -1.4 0.0
Back pain experienced in last month 0.7 1.0 2.9 -1.7 -1.0 0.0 -0.4
Mineral and other dietary supplements 0.1 0.2 0.4 -0.6 0.0 0.2 0.4
Breast cancer (self-reported) 0.0 0.1 0.2 -0.4 -0.0 0.2 -0.0
Asthma (self-reported) 1.0 2.0 6.4 2.5 0.8 0.5 0.8
Osteoporosis (self-reported) 0.6 0.8 1.4 0.7 -0.1 -1.2 -1.1
Osteoarthritis (self-reported) 0.1 0.2 0.3 0.6 0.0 -0.1 -0.6
Medication: Aspirin 0.5 0.6 2.2 1.5 0.1 0.4 0.4
Medication: Gliclazide 0.5 0.5 2.0 -0.3 -0.2 -1.4 0.2
Illnesses of father: None of the above (group 1) 0.3 0.4 0.8 0.2 -0.8 -0.4 -0.9
Smoking status: Current 0.3 0.5 0.9 -0.9 -1.0 -0.4 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 5.0 0.2 1.4 -2.2 -0.2
Whole body water mass 0.5 2.8 9.5 -3.1 -1.1 -0.2 0.7
Leg predicted mass (right) 0.4 2.1 6.9 -2.6 -0.5 -0.4 1.0
Arm fat mass (left) 0.4 1.6 2.8 -1.7 -1.3 1.1 1.0
Number of self-reported non-cancer illnesses 0.6 1.1 2.7 0.7 -1.6 0.9 0.5
Average weekly champagne plus white wine intake 0.5 0.6 1.7 -1.3 0.4 0.8 0.3
Miserableness 0.8 1.3 4.4 -0.5 -0.6 -0.6 -2.1
Guilty feelings 1.1 1.7 4.0 -0.1 -1.5 2.0 -0.7
Wears glasses or contact lenses 1.2 1.4 2.7 -0.9 -1.6 1.0 -1.0
Ever taken oral contraceptive pill 2.1 2.3 5.2 0.8 1.7 -2.3 0.8
Hearing aid user 0.6 0.7 2.7 0.0 0.0 -1.6 0.1
Mother’s age at death 0.6 0.7 1.4 -0.4 -1.0 0.5 -1.2
Financial situation satisfaction 0.6 0.7 1.9 -0.8 -0.5 -1.4 -0.0
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.5 0.2 0.3 -0.7 0.6
Commuting to job workplace: Public transport 0.2 0.3 0.7 -0.2 -0.6 -0.1 -0.8
Eye problems/disorders: Glaucoma 0.1 0.2 0.4 -0.0 0.6 0.5 -0.2
Medication: Blood pressure 0.3 0.5 0.9 0.6 -0.7 -1.0 0.2
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.1 -0.4 -0.9 1.4 0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.8 -0.0 -1.1 1.4 -0.9
High cholesterol (Self-reported) 0.8 1.5 4.4 2.1 0.9 -0.6 -0.3
Medication: Bendroflumethiazide 0.3 0.5 0.9 0.9 -0.3 0.2 0.9
Medication: Paracetamol 0.6 0.9 3.1 1.8 0.5 -0.2 0.6
Medication: Lisinopril 0.7 0.9 1.2 0.5 1.1 -1.0 1.0
Medication: Atorvastatin 0.0 0.1 0.1 0.0 0.1 -0.3 0.4
Illnesses of father: High blood pressure 2.4 3.0 7.4 0.8 2.7 -1.5 1.3
Alcohol drinker status: Never 0.3 0.4 1.2 -0.5 -0.2 -1.1 0.3
Ever smoked 0.2 0.4 1.3 -0.7 -0.0 -1.1 -0.1
Basal metabolic rate 0.5 2.8 9.0 -3.0 -1.0 -0.2 1.0
Leg fat percentage (left) 0.2 0.8 1.6 -0.6 -0.9 0.6 1.3
Arm fat-free mass (left) 0.6 2.8 9.0 -3.0 -1.5 0.2 0.4
Number of operations (self-reported) 0.2 0.2 0.7 -0.4 -0.8 0.0 -0.4
Average weekly beer plus cider intake 1.4 2.0 5.8 1.4 0.2 0.5 2.4
Irritability 1.0 1.6 3.5 1.3 0.9 -1.9 0.6
Risk taking 0.0 0.1 0.1 -0.3 0.1 -0.2 -0.3
Ever had prostate specific antigen (PSA) test 2.6 3.0 4.6 -2.1 -2.1 1.4 -1.0
Fractured/broken bones in last 5 years 0.2 0.3 0.7 -0.4 0.1 -0.9 0.4
Age started oral contraceptive pill 0.4 0.6 0.8 0.9 -0.7 0.9 0.4
Diastolic blood pressure, automated reading 0.3 1.0 2.2 -0.4 0.5 1.2 1.5
Ever depressed for a whole week 0.9 1.1 2.4 0.2 1.6 -1.4 -0.5
Unable to work because of sickness or disability 0.4 0.5 1.7 -0.5 -1.3 -0.4 0.3
Commuting to job workplace: Cycle 0.4 0.5 1.7 0.4 -0.2 0.3 -1.3
Myopia 0.7 1.1 3.7 -1.9 -0.7 -0.3 -0.0
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.3 -1.3 -0.0 0.6 -1.5
Cholesterol lowering medication 0.6 0.9 1.9 1.4 0.1 -1.2 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 3.6 1.9 1.8 -1.2 1.0
Pain experienced in last month 0.2 0.3 1.2 -0.2 0.0 0.0 -1.1
Supplements: Calcium 0.8 0.9 3.2 0.6 0.2 -1.8 0.1
Basal cell carcinoma (self-reported) 1.2 1.4 3.0 -1.7 -1.2 1.0 -0.4
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.1 -0.4 -0.1 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.9 -0.3 -1.4 0.0 -0.3
Heart disease (siblings) 0.7 0.9 1.5 -1.2 -0.3 -1.1 -0.9
Alcohol drinker status: Previous 0.7 0.7 1.9 0.9 0.5 -1.4 0.2
Pack years of smoking 1.2 1.7 4.9 -1.2 -2.2 -0.4 -0.5
Impedance of whole body 0.3 1.3 4.4 0.5 0.7 0.0 -2.1
Leg fat mass (left) 0.4 1.5 2.8 -1.7 -1.4 0.4 1.1
Arm predicted mass (left) 0.6 2.9 9.4 -3.1 -1.4 -0.1 0.5