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chr1:31,188,089-34,592,020

Best TWAS P=1.75e-42 · Best GWAS P=2.83e-43 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MTMR9LP	0.11	0.11	lasso	23	0.11	6.5e-13	4.38	5.2	1.6e-07	0.34	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PEF1	0.04	0.04	lasso	4	0.03	2.8e-04	-6.09	6.1	8.4e-10	0.04	0.84	0.04	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMEM54	0.05	0.00	blup	281	0.02	4.5e-03	-0.78	-5.5	4.7e-08	-0.07	0.10	0.30	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TXLNA	0.04	0.04	bslmm	221	0.03	1.8e-04	8.48	-6.5	6.3e-11	-0.20	0.84	0.01	FALSE
5	CommonMind	Brain Pre-frontal Cortex	ZNF362	0.05	0.06	lasso	1	0.06	2.2e-07	-8.30	-8.3	1.1e-16	-0.09	0.00	1.00	TRUE
6	GTEx	Artery Aorta	PEF1	0.15	0.05	lasso	5	0.04	2.2e-03	-9.54	10.6	2.2e-26	0.10	0.51	0.02	TRUE
7	GTEx	Artery Tibial	PEF1	0.10	0.09	enet	16	0.09	9.0e-08	-6.10	6.7	2.4e-11	0.06	0.99	0.00	FALSE
8	GTEx	Brain Caudate basal ganglia	FAM167B	0.43	0.00	lasso	11	0.00	3.0e-01	-1.35	6.4	1.8e-10	0.34	0.02	0.21	FALSE
9	GTEx	Brain Cerebellum	RP11-415J8.3	0.25	0.06	lasso	3	0.07	4.2e-03	7.61	-7.4	1.1e-13	-0.11	0.13	0.14	FALSE
10	GTEx	Breast Mammary Tissue	SYNC	0.20	0.00	lasso	4	0.01	6.9e-02	-1.87	5.8	8.4e-09	0.15	0.14	0.24	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	KPNA6	0.19	0.14	enet	18	0.10	4.9e-04	8.46	8.9	7.5e-19	0.36	0.22	0.05	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	PHC2	0.58	0.34	lasso	7	0.28	7.3e-10	-7.89	7.3	2.1e-13	0.10	0.02	0.98	FALSE
13	GTEx	Cells Transformed fibroblasts	KPNA6	0.13	0.10	lasso	5	0.11	1.3e-08	8.44	8.4	3.0e-17	0.38	1.00	0.00	FALSE
14	GTEx	Colon Sigmoid	PEF1	0.16	0.09	lasso	3	0.09	4.3e-04	-7.19	8.7	3.3e-18	0.06	0.21	0.05	FALSE
15	GTEx	Esophagus Mucosa	MTMR9LP	0.07	0.09	lasso	3	0.05	1.5e-04	4.50	5.6	2.0e-08	0.35	0.73	0.10	TRUE
16	GTEx	Nerve Tibial	TXLNA	0.10	0.00	enet	5	0.00	6.8e-01	-2.71	-6.9	5.4e-12	-0.32	0.04	0.04	TRUE
17	GTEx	Skin Not Sun Exposed Suprapubic	EIF3I	0.12	0.06	lasso	1	0.03	7.2e-03	8.41	-8.4	4.1e-17	-0.38	0.09	0.04	FALSE
18	GTEx	Skin Sun Exposed Lower leg	PEF1	0.05	0.03	enet	9	0.02	4.6e-03	-9.54	8.0	1.5e-15	0.10	0.66	0.01	FALSE
19	GTEx	Testis	RP4-622L5.7	0.12	0.11	lasso	5	0.08	2.3e-04	8.48	8.5	1.8e-17	0.38	0.35	0.13	FALSE
20	GTEx	Whole Blood	SERINC2	0.34	0.14	enet	54	0.15	1.1e-13	-2.57	6.0	2.7e-09	0.12	1.00	0.00	TRUE
21	METSIM	Adipose	KPNA6	0.07	0.06	lasso	10	0.06	1.8e-09	8.50	8.8	8.8e-19	0.40	1.00	0.00	FALSE
22	METSIM	Adipose	PEF1	0.03	0.02	enet	17	0.02	7.9e-04	-6.39	5.2	2.4e-07	0.17	0.42	0.03	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	KPNA6	0.03	0.04	lasso	4	0.02	8.1e-04	8.34	8.7	2.4e-18	0.42	0.61	0.20	TRUE
24	ROSMAP	Brain Pre-frontal Cortex	PHC2	0.11	0.07	lasso	3	0.05	2.2e-07	-7.89	-7.5	9.7e-14	-0.09	0.01	0.99	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	PEF1	0.04	0.04	lasso	3	0.02	4.2e-04	-6.53	6.1	1.2e-09	0.06	0.82	0.01	FALSE
26	YFS	Blood	KPNA6	0.03	0.03	bslmm	236	0.04	1.1e-11	8.62	9.5	1.7e-21	0.40	1.00	0.00	FALSE
27	YFS	Blood	PEF1	0.05	0.02	blup	346	0.03	2.8e-11	-7.19	5.2	1.7e-07	0.06	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF362	0.03	0.01	blup	49	0.01	1.3e-03	2.72	-5.3	1.3e-07	-0.05	0.01	0.31	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM39B	0.04	0.03	blup	16	0.03	5.0e-04	8.50	-8.2	2.5e-16	-0.31	0.01	0.94	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MTMR9L	0.03	0.03	blup	28	0.01	1.6e-02	4.65	7.6	2.1e-14	0.39	0.04	0.55	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	KPNA6	0.02	0.02	blup	29	0.02	1.9e-03	8.49	8.4	3.0e-17	0.36	0.02	0.83	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTMR9L	0.04	0.04	blup	29	0.02	1.0e-03	4.50	7.0	2.3e-12	0.40	0.20	0.45	TRUE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	MTMR9L	0.03	0.00	blup	30	0.01	1.0e-02	4.38	7.4	1.2e-13	0.32	0.01	0.60	FALSE
34	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM39B	0.05	0.04	enet	9	0.05	1.7e-04	8.49	-6.6	4.0e-11	-0.22	0.01	0.82	FALSE
35	The Cancer Genome Atlas	Skin Cutaneous Melanoma	MTMR9L	0.15	0.02	blup	29	0.09	2.8e-03	4.77	7.4	1.8e-13	0.35	0.01	0.38	FALSE
36	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PTP4A2	0.09	-0.01	blup	26	0.00	4.1e-01	10.66	13.7	1.8e-42	0.80	0.01	0.56	TRUE
37	The Cancer Genome Atlas	Thyroid Carcinoma	FAM167B	0.03	0.01	blup	26	0.02	2.4e-03	4.65	-6.7	1.7e-11	-0.37	0.02	0.74	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	KPNA6	0.03	0.03	blup	28	0.03	5.3e-04	8.62	8.5	1.4e-17	0.34	0.02	0.88	TRUE
39	The Cancer Genome Atlas	Thyroid Carcinoma	MTMR9L	0.03	0.04	blup	28	0.03	3.3e-04	4.38	7.6	3.7e-14	0.38	0.03	0.92	TRUE
40	The Cancer Genome Atlas	Thyroid Carcinoma	SPOCD1	0.04	0.02	blup	38	0.02	3.0e-03	-4.85	5.9	3.6e-09	0.34	0.04	0.11	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	TINAGL1	0.05	0.03	enet	5	0.03	1.2e-03	-6.53	-5.5	3.2e-08	-0.08	0.01	0.23	FALSE