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chr16:30,347,731-31,833,122

Best TWAS P=1.11e-09 · Best GWAS P=3.51e-09 conditioned to 0.244

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	GTEx	Esophagus Mucosa	STX1B	0.12	0.03	lasso	5	0.05	1.7e-04	-5.9	-6.1	1.1e-09	0.88	0.02	0.97	TRUE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BCL7C	0.04	0.01	blup	29	0.02	6.9e-03	-5.4	6.0	2.0e-09	-0.82	0.01	0.84	FALSE
43	GTEx	Skin Sun Exposed Lower leg	RP11-196G11.2	0.16	0.15	lasso	7	0.15	4.0e-12	-5.8	-6.0	2.3e-09	0.98	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HSD3B7	0.04	0.02	enet	13	0.03	2.1e-03	-5.8	-6.0	2.3e-09	0.88	0.02	0.62	FALSE
44	GTEx	Small Intestine Terminal Ileum	RP11-196G11.2	0.18	0.07	enet	15	0.06	1.5e-02	-5.6	-6.0	2.5e-09	0.82	0.03	0.78	FALSE
28	GTEx	Lung	RP11-196G11.2	0.21	0.12	enet	22	0.14	1.6e-10	-5.9	-5.9	2.8e-09	0.90	0.02	0.98	FALSE
32	GTEx	Nerve Tibial	HSD3B7	0.09	0.05	lasso	3	0.03	2.4e-03	-5.9	-5.9	2.9e-09	0.99	0.03	0.89	FALSE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HSD3B7	0.09	0.12	blup	31	0.11	4.1e-05	-5.7	-5.9	3.7e-09	0.95	0.02	0.95	FALSE
49	GTEx	Thyroid	RP11-196G11.2	0.11	0.14	lasso	2	0.14	3.5e-11	-5.9	-5.9	3.8e-09	1.00	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STX1B	0.02	0.01	blup	32	0.01	5.5e-02	-5.8	-5.9	3.8e-09	0.96	0.02	0.60	FALSE
33	GTEx	Nerve Tibial	RP11-196G11.2	0.17	0.22	lasso	6	0.22	2.3e-15	-5.6	-5.9	4.0e-09	0.97	0.03	0.97	FALSE
6	GTEx	Artery Coronary	RP11-196G11.2	0.12	0.06	lasso	6	0.06	3.4e-03	-5.7	-5.9	4.7e-09	0.96	0.03	0.91	FALSE
12	GTEx	Brain Cerebellum	RP11-196G11.2	0.31	0.30	lasso	4	0.36	1.3e-11	-5.8	-5.9	4.7e-09	0.98	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	RP11-196G11.2	0.23	0.20	lasso	9	0.21	4.2e-17	-5.7	-5.8	4.9e-09	0.99	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HSD3B7	0.05	0.06	lasso	4	0.07	5.5e-09	-5.8	-5.8	5.0e-09	0.97	0.02	0.98	FALSE
24	GTEx	Esophagus Mucosa	RP11-196G11.2	0.09	0.03	enet	13	0.05	1.5e-04	-5.7	-5.8	5.0e-09	0.91	0.04	0.95	FALSE
4	GTEx	Artery Aorta	STX1B	0.17	0.18	lasso	6	0.15	1.9e-08	-5.8	-5.8	5.1e-09	0.96	0.02	0.98	FALSE
52	METSIM	Adipose	RP11-196G11.2	0.13	0.17	lasso	9	0.16	2.2e-23	-5.8	-5.8	5.1e-09	0.97	0.02	0.98	FALSE
16	GTEx	Cells Transformed fibroblasts	RP11-196G11.2	0.14	0.14	lasso	6	0.13	2.9e-10	-5.8	-5.8	5.2e-09	0.98	0.02	0.98	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	RP11-196G11.2	0.12	0.12	lasso	4	0.12	1.1e-14	-5.8	-5.8	5.2e-09	0.97	0.02	0.98	FALSE
11	GTEx	Brain Cerebellum	STX4	0.14	0.25	lasso	1	0.24	8.3e-08	-5.8	-5.8	6.0e-09	0.97	0.02	0.97	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	STX4	0.06	0.11	lasso	10	0.11	1.4e-13	-5.8	5.8	6.0e-09	-0.97	0.03	0.97	FALSE
8	GTEx	Brain Cerebellar Hemisphere	STX1B	0.13	0.11	lasso	5	0.10	1.5e-03	-5.6	-5.8	6.8e-09	0.96	0.03	0.75	FALSE
57	YFS	Blood	STX4	0.03	0.06	lasso	2	0.05	4.3e-17	-5.8	-5.8	7.2e-09	0.95	0.02	0.98	FALSE
48	GTEx	Testis	RP11-196G11.2	0.14	0.11	lasso	4	0.13	3.1e-06	-5.6	-5.8	7.4e-09	0.98	0.03	0.97	FALSE
50	GTEx	Uterus	RP11-196G11.2	0.18	0.16	lasso	20	0.15	5.4e-04	-5.7	-5.8	7.4e-09	0.98	0.04	0.92	FALSE
41	GTEx	Skin Sun Exposed Lower leg	STX1B	0.05	0.04	enet	4	0.05	7.2e-05	-5.7	-5.8	7.8e-09	0.99	0.03	0.96	FALSE
37	GTEx	Pituitary	HSD3B7	0.13	0.07	lasso	7	0.05	2.1e-02	-5.6	-5.8	8.7e-09	0.94	0.05	0.86	FALSE
25	GTEx	Esophagus Muscularis	STX4	0.05	0.05	lasso	3	0.03	6.7e-03	-5.6	-5.8	8.9e-09	0.97	0.02	0.95	FALSE
19	GTEx	Colon Transverse	RP11-196G11.2	0.24	0.11	lasso	5	0.15	1.9e-07	-5.6	-5.7	9.9e-09	0.96	0.03	0.97	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	RP11-196G11.2	0.22	0.21	lasso	9	0.26	3.2e-14	-5.7	-5.7	9.9e-09	0.97	0.03	0.97	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	HSD3B7	0.03	0.05	lasso	6	0.02	3.0e-04	-5.8	-5.7	1.0e-08	0.96	0.02	0.98	FALSE
5	GTEx	Artery Aorta	RP11-196G11.2	0.10	0.16	lasso	2	0.14	7.1e-08	-5.6	-5.7	1.1e-08	0.97	0.03	0.97	FALSE
27	GTEx	Heart Left Ventricle	HSD3B7	0.12	0.08	lasso	3	0.07	2.0e-04	-5.6	-5.7	1.1e-08	0.97	0.05	0.94	FALSE
46	GTEx	Testis	STX1B	0.26	0.23	lasso	5	0.25	1.2e-11	-5.8	-5.7	1.1e-08	0.96	0.02	0.98	FALSE
34	GTEx	Ovary	RP11-196G11.2	0.41	0.22	lasso	10	0.25	6.0e-07	-5.8	-5.7	1.2e-08	0.96	0.04	0.96	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	HSD3B7	0.20	0.27	lasso	12	0.28	1.8e-27	-5.8	-5.7	1.2e-08	0.94	0.02	0.98	FALSE
14	GTEx	Breast Mammary Tissue (Male)	RP11-196G11.2	0.15	0.16	lasso	4	0.09	3.9e-03	-5.7	-5.7	1.3e-08	0.99	0.03	0.92	FALSE
18	GTEx	Colon Transverse	STX4	0.10	0.09	lasso	3	0.06	6.6e-04	-5.7	-5.7	1.4e-08	0.99	0.03	0.93	FALSE
29	GTEx	Muscle Skeletal	STX4	0.04	0.04	lasso	3	0.03	2.9e-04	-5.8	-5.7	1.4e-08	0.95	0.03	0.97	FALSE
30	GTEx	Muscle Skeletal	RP11-196G11.2	0.15	0.10	enet	10	0.12	1.0e-11	-5.8	-5.7	1.4e-08	0.95	0.03	0.97	FALSE
35	GTEx	Pancreas	STX1B	0.23	0.18	lasso	3	0.16	2.8e-07	-5.7	-5.7	1.4e-08	0.99	0.04	0.96	FALSE
42	GTEx	Skin Sun Exposed Lower leg	HSD3B7	0.12	0.17	lasso	5	0.16	2.7e-13	-5.4	-5.7	1.5e-08	0.95	0.06	0.94	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	STX1B	0.08	0.10	lasso	7	0.10	3.0e-12	-5.7	-5.6	1.8e-08	0.93	0.04	0.96	FALSE
36	GTEx	Pancreas	RP11-196G11.2	0.13	0.11	lasso	1	0.11	2.5e-05	-5.6	-5.6	2.0e-08	0.97	0.03	0.96	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRSS53	0.06	0.02	enet	7	0.04	4.7e-05	-5.6	5.6	2.1e-08	-0.97	0.01	0.99	FALSE
38	GTEx	Pituitary	RP11-196G11.2	0.21	0.28	lasso	6	0.23	1.4e-06	-5.7	-5.6	2.2e-08	0.97	0.03	0.95	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYST1	0.08	0.04	blup	34	0.07	7.2e-08	3.8	-5.6	2.3e-08	0.87	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD3B7	0.04	0.04	blup	31	0.05	3.6e-04	-5.8	-5.6	2.5e-08	0.94	0.02	0.88	FALSE
10	GTEx	Brain Cerebellum	STX1B	0.24	0.16	lasso	11	0.18	4.8e-06	-5.7	-5.5	2.9e-08	0.95	0.03	0.96	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD3B7	0.24	0.27	lasso	6	0.26	2.0e-27	-5.4	-5.5	3.4e-08	0.93	0.04	0.96	FALSE
26	GTEx	Esophagus Muscularis	RP11-196G11.2	0.14	0.14	lasso	6	0.13	3.7e-08	-5.7	-5.5	3.9e-08	0.96	0.02	0.98	FALSE
23	GTEx	Esophagus Mucosa	STX4	0.08	0.00	enet	21	0.02	1.0e-02	-5.4	-5.5	4.0e-08	0.81	0.06	0.89	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD3B7	0.03	0.03	blup	31	0.04	5.2e-08	-5.6	-5.5	4.0e-08	0.94	0.02	0.98	FALSE
9	GTEx	Brain Cerebellar Hemisphere	RP11-196G11.2	0.18	0.06	lasso	6	0.10	1.7e-03	-5.8	-5.5	4.9e-08	0.94	0.03	0.89	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	STX1B	0.04	0.03	blup	32	0.04	9.5e-05	-5.8	-5.5	5.0e-08	0.94	0.02	0.97	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRSS53	0.03	0.03	blup	38	0.02	6.8e-06	-5.6	5.4	5.6e-08	-0.94	0.01	0.99	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	HSD3B7	0.11	0.12	enet	6	0.10	5.9e-06	-5.8	-5.4	5.9e-08	0.96	0.03	0.97	FALSE
63	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HSD3B7	0.08	0.05	blup	31	0.05	1.8e-03	-5.4	-5.4	5.9e-08	0.93	0.03	0.93	FALSE
31	GTEx	Nerve Tibial	STX1B	0.21	0.14	enet	17	0.18	1.6e-12	-5.7	-5.4	6.0e-08	0.97	0.04	0.96	FALSE
51	GTEx	Whole Blood	RP11-196G11.2	0.07	0.05	lasso	3	0.06	1.4e-06	-5.6	-5.4	6.2e-08	0.91	0.05	0.95	FALSE
22	GTEx	Esophagus Mucosa	HSD3B7	0.38	0.32	lasso	5	0.36	1.2e-24	-5.8	-5.4	6.8e-08	0.96	0.03	0.97	FALSE
13	GTEx	Breast Mammary Tissue	RP11-196G11.2	0.13	0.16	lasso	4	0.17	5.0e-09	-5.7	-5.3	1.1e-07	0.98	0.04	0.96	FALSE
7	GTEx	Artery Tibial	RP11-196G11.2	0.08	0.04	lasso	4	0.03	3.8e-03	-5.6	-5.3	1.2e-07	0.96	0.03	0.96	FALSE
45	GTEx	Stomach	RP11-196G11.2	0.25	0.16	enet	21	0.14	4.6e-07	-3.9	-5.3	1.3e-07	0.78	0.20	0.79	FALSE
3	GTEx	Adrenal Gland	HSD3B7	0.21	0.17	lasso	4	0.13	2.9e-05	-5.8	-5.3	1.5e-07	0.95	0.03	0.93	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	-4.0	-5.3	1.5e-07	0.86	0.05	0.94	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	PRSS53	0.11	0.04	enet	8	0.05	9.7e-06	-5.8	5.2	1.7e-07	-0.85	0.01	0.98	FALSE
47	GTEx	Testis	STX4	0.15	0.02	lasso	6	0.01	8.2e-02	-5.8	-5.2	2.0e-07	0.95	0.03	0.84	FALSE
15	GTEx	Cells Transformed fibroblasts	STX1B	0.12	0.10	lasso	5	0.10	6.8e-08	-5.6	-5.2	2.3e-07	0.94	0.03	0.97	FALSE
17	GTEx	Colon Transverse	HSD3B7	0.16	0.15	enet	20	0.19	2.1e-09	-5.6	-5.2	2.3e-07	0.91	0.04	0.96	FALSE