TWAS hub - MUSTN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1530	0.0510	2.7e-08	0.137	NA	0.099	NA	0.112	5.3e-08	NA	4.3e-06	NA	9.5e-07
2	YFS	Blood	0.0989	0.0325	2.9e-11	0.030	0.04	0.048	0.04	0.042	4.1e-10	4.2e-13	2.8e-15	3.6e-13	1.1e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2011)	18.8	18.2	21.2	-4.6	3.9
Bipolar Disorder or Schizophrenia	14.3	34.8	38.0	-6.2	5.6
Worrier / anxious feelings	12.9	24.4	43.2	-6.6	2.4
Worry (Nagel 2018)	12.7	26.9	48.1	-6.9	2.4
Bipolar Disorder (2018)	10.9	17.3	18.9	-4.0	4.3
Schizophrenia (2014)	9.0	19.9	25.6	-5.1	3.8
Schizophrenia (2018)	8.7	18.0	22.5	-4.7	3.7
BMI	8.4	48.9	67.7	8.2	-5.5
Nervous feelings	8.1	15.1	25.8	-5.1	2.1
Impedance of arm (right)	7.6	35.2	39.3	-6.3	5.6
Smoking Status	7.3	17.5	27.2	5.2	-2.8
Number of incorrect matches in round	7.3	12.2	16.6	-4.1	2.8
Impedance of whole body	7.3	37.2	44.6	-6.7	5.5
Impedance of arm (left)	7.2	33.4	38.2	-6.2	5.3
Headache pain in last month	6.9	11.9	16.1	-4.0	2.8
Body mass index (BMI)	6.8	28.9	32.9	5.7	-5.0
Hearing aid user	6.8	7.7	11.1	2.0	-3.3
Standing height	6.6	65.3	79.7	-8.9	7.1
Height	6.3	121.8	166.4	-12.9	8.8
Happiness	6.3	7.7	8.1	-2.7	2.9
Verbal and Numeric Reasoning (VNR)	5.4	12.9	25.5	5.0	0.6
Hand grip strength (left)	5.4	14.2	17.4	-4.2	3.3
Past tobacco smoking	5.2	9.5	16.3	-4.0	1.7
Tense / ‘highly strung’	5.2	8.6	14.1	-3.8	1.7
Intelligence (Savage-Jansen 2018)	5.1	15.7	31.5	5.6	-0.1
Impedance of leg (right)	5.0	24.4	25.4	-5.0	4.8
Townsend deprivation index at recruitment	5.0	7.0	10.4	3.2	-1.9
Impedance of leg (left)	5.0	24.1	28.2	-5.3	4.5
Diabetes diagnosed by doctor	5.0	8.1	12.1	3.5	-2.0
Blood Eosinophil Count	4.9	37.4	48.7	7.0	-5.1
Sitting height	4.8	34.0	53.3	-7.3	3.8
Diabetes (self-reported)	4.8	7.4	10.8	3.3	-2.0
Neuroticism (Nagel 2018)	4.7	11.0	20.4	-4.5	1.2
Alcohol usually taken with meals	4.7	7.7	9.1	-2.5	3.0
Gout (self-reported)	4.6	6.4	7.8	-2.2	-2.8
Ever highly irritable/argumentative for 2 days	4.5	5.4	9.6	3.1	-1.1
Type 2 Diabetes (T2D) (2018)	4.4	8.2	12.5	3.5	-2.0
Neuroticism	4.4	10.6	18.8	-4.3	1.6
Comparative height size at age 10	4.4	24.5	31.9	-5.7	4.1
Family relationship satisfaction	4.4	5.4	6.4	-2.5	2.1
Forced expiratory volume in 1-second (FEV1), predicted	4.4	9.2	14.4	-3.8	2.0
Systolic blood pressure, automated reading	4.3	12.6	21.7	1.8	-4.7
Serious illness, injury or assault of a close relative in last 2 years	4.3	5.0	7.6	-1.5	2.8
Friendships satisfaction	4.3	5.3	7.0	-2.6	1.9
Ever smoked	4.3	7.5	13.3	3.7	-1.3
Major Depression (MDD)	4.2	5.1	9.2	-3.0	1.0
Crohns Disease (2012)	4.2	6.8	10.3	-1.8	3.2
Fluid intelligence score	4.2	8.8	15.4	3.9	1.5
Heel bone mineral density (BMD) T-score, automated (right)	4.1	9.4	11.0	2.8	-3.3
Basal cell carcinoma (self-reported)	4.1	4.9	5.9	-2.4	2.0
LDL Cholesterol	4.0	6.3	10.2	3.2	-1.5
Qualifications: None of the above	4.0	8.6	12.9	2.1	-3.6
Prospective memory result	4.0	4.9	8.1	-2.9	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	4.0	6.2	9.8	-3.1	1.6
Suffer from ‘nerves’	3.9	6.2	11.8	-3.4	0.8
Hand grip strength (right)	3.8	10.4	11.7	-3.4	3.0
Depression (self-reported)	3.8	4.6	9.2	-3.0	0.0
Smoking status: Previous	3.7	5.6	9.9	3.2	-1.1
Neuroticism (2016)	3.6	5.3	8.0	-2.8	1.6
HDL Cholesterol	3.5	5.9	9.9	-1.4	3.1
Medication: Allopurinol	3.5	4.7	7.4	-1.4	-2.7
Qualifications: nursing, teaching	3.5	5.5	11.0	0.1	3.3
Leg fat percentage (left)	3.5	12.8	15.4	3.9	-3.2
Number of treatments/medications taken	3.4	6.0	9.6	1.6	-3.1
Shortness of breath walking on level ground	3.4	4.0	6.6	1.2	-2.6
Qualifications: College or University degree	3.4	10.6	14.6	-2.6	3.8
Depression (Nagel 2018)	3.3	5.0	7.4	-2.7	1.6
Average weekly fortified wine intake	3.3	3.8	3.8	-2.0	2.0
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.4	8.3	2.6	-2.9
Average weekly spirits intake	3.2	3.9	7.2	2.7	-0.8
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	10.0	-3.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.1	7.8	-2.8	0.7
Ulcerative Colitis	3.1	4.5	8.8	-3.0	-0.5
Alcohol intake versus 10 years previously	3.1	4.6	7.0	2.6	-1.5
Leg fat percentage (right)	3.1	11.2	15.3	3.9	-2.6
Cardiovascular Disease	3.0	10.0	12.1	3.5	-2.8
Crohns Disease (2017)	2.9	6.3	7.9	-2.2	2.8
Heel T-Score	2.9	23.3	24.6	5.0	-4.7
Forced vital capacity (FVC), Best measure	2.9	10.6	20.7	-4.5	0.7
Migraine (self-reported)	2.9	3.7	5.6	-2.4	1.3
Chest pain or discomfort	2.9	4.1	5.7	-2.4	1.6
Chronotype (morning person)	2.7	6.2	9.1	1.8	-3.0
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	4.1	-1.7	2.0
Mineral and other dietary supplements	2.7	3.6	4.9	-2.2	1.5
Blood Red Count	2.6	25.4	47.7	-6.9	1.7
Forced vital capacity (FVC)	2.6	9.9	19.5	-4.4	0.5
Type 2 Diabetes (T2D) (2012)	2.5	2.9	3.7	1.4	-1.9
Waist Hip Ratio (WHR)	2.5	11.4	16.6	-4.1	2.5
Arm fat percentage (right)	2.5	9.8	11.4	3.4	-2.9
Hypertension (Self-reported)	2.5	6.8	10.1	1.9	-3.2
Myopia	2.5	3.6	6.8	2.6	0.6
HbA1C	2.4	2.7	4.4	1.0	-2.1
Pulse rate	2.4	4.1	6.0	-2.4	1.5
Guilty feelings	2.4	3.6	7.0	-2.6	0.5
Supplements: Fish oil (including cod liver oil)	2.4	3.2	3.2	1.8	-1.8
Irritable Bowel Disease (IBD)	2.3	5.5	8.7	-3.0	1.5
Frequency of depressed mood in last 2 weeks	2.3	3.2	5.8	-2.4	0.7
Comparative body size at age 10	2.3	6.5	11.5	3.4	-1.2
Arm fat percentage (left)	2.3	9.2	10.1	3.2	-2.9
Systolic Blood Pressure	2.2	10.8	14.9	2.6	-3.9
Birth weight	2.2	4.8	7.0	-2.6	1.6
Long-standing illness, disability or infirmity	2.2	3.4	4.3	1.6	-2.1
Leg fat mass (left)	2.2	8.5	10.1	3.2	-2.6
High blood pressure	2.1	5.8	9.0	1.6	-3.0
Medication: Blood pressure	2.1	3.6	5.4	1.4	-2.3
Relative age voice broke	2.0	3.0	5.7	2.4	0.5
Stomach or abdominal pain in last month	2.0	2.5	3.9	-2.0	1.1
Leg fat mass (right)	2.0	7.8	10.3	3.2	-2.3
Knee pain experienced in last month	2.0	3.1	3.7	1.9	-1.6
Arm fat mass (left)	2.0	8.1	8.7	3.0	-2.7
Vascular/heart problems diagnosed by doctor	2.0	5.4	7.9	-1.7	2.8
Medication: Ramipril	1.9	2.4	4.2	0.8	-2.0
Neuroticism score	1.9	3.9	7.7	-2.8	-0.1
Birth weight of first child	1.9	3.5	5.8	-1.1	2.4
Pulse wave reflection index	1.9	2.3	4.6	2.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.6	-0.9	1.9
Smoking status: Current	1.9	3.0	4.8	2.2	-1.0
High cholesterol (Self-reported)	1.9	3.4	3.8	1.7	-2.0
Multivitamins +/- minerals	1.8	2.3	4.4	2.1	0.3
Time employed in main current job	1.8	2.1	2.3	1.3	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.9	11.6	-3.4	0.5
Arm fat mass (right)	1.8	7.3	8.0	2.8	-2.6
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	3.6	-1.6	1.9
Pulse wave peak to peak time	1.8	2.1	2.2	-1.5	1.4
Leg pain on walking	1.8	2.3	3.2	1.2	-1.8
Financial situation satisfaction	1.8	2.3	3.6	1.0	-1.9
Medication: Lisinopril	1.8	2.3	3.3	1.2	-1.8
Blood Platelet Count	1.7	19.8	21.5	4.2	-4.6
Forced expiratory volume in 1-second (FEV1)	1.7	5.8	11.2	-3.4	0.6
Eye problems/disorders: None of the above	1.7	1.9	3.7	1.9	0.4
Medication: Bendroflumethiazide	1.7	2.6	3.1	1.4	-1.8
Severe depression (siblings)	1.6	1.7	2.2	-1.1	1.5
Medication: Amlodipine	1.6	2.2	4.1	0.6	-2.0
Worry too long after embarrassment	1.6	2.8	5.1	-2.3	0.7
Back pain experienced in last month	1.6	2.3	2.6	1.6	-1.4
Tinnitus: Yes, now most or all of the time	1.6	1.9	2.6	-1.6	-1.1
Fractured/broken bones in last 5 years	1.6	2.1	3.6	0.8	-1.9
Diastolic blood pressure, automated reading	1.6	5.1	9.4	-0.9	-3.1
Age at First Birth	1.5	2.2	4.2	2.1	-0.5
Body Mass Index (BMI) (2010)	1.5	2.1	4.1	2.0	-0.2
Hearing difficulty/problems: Yes	1.5	2.2	3.9	0.8	-2.0
Length of working week for main job	1.5	1.7	3.1	1.8	-0.5
Number of full brothers	1.5	1.9	3.3	1.8	0.7
Eye problems/disorders: Cataract	1.5	1.8	2.9	-1.7	0.8
Medication for cholesterol	1.5	2.3	3.8	-2.0	0.9
Ever taken oral contraceptive pill	1.5	1.7	2.8	1.7	-0.8
Primary Biliary Cirrhosis	1.4	2.0	3.3	1.8	-0.8
Medication: Metformin	1.4	2.0	3.2	1.8	-0.9
Pack years adult smoking proportion	1.4	2.2	4.2	-0.5	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	4.3	-2.1	0.3
Medication: Cholesterol lowering	1.4	2.2	3.9	2.0	-0.8
Medication: Paracetamol	1.4	2.4	4.6	-2.1	0.4
Emphysema/chronic bronchitis	1.4	1.6	1.6	-1.3	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.4	1.9	1.0	-1.4
Illnesses of father: High blood pressure	1.4	1.8	3.1	-0.6	-1.8
Ulcerative Colitis (UC)	1.3	2.4	4.4	-2.1	-0.7
Chronic bronchitis/emphysema (father)	1.3	1.5	3.1	0.0	1.8
Had major operations	1.3	1.5	2.4	1.6	0.7
Commuting to job workplace: Cycle	1.3	1.6	3.0	0.5	-1.7
Rheumatoid Arthritis	1.2	1.6	2.7	1.6	-0.7
Diabetes (father)	1.2	1.5	2.9	1.7	-0.4
Current tobacco smoking	1.2	2.0	3.3	1.8	-0.8
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.0	-1.7	-0.4
Mouth/teeth dental problems: Dentures	1.2	2.0	3.3	0.8	-1.8
Hair/balding pattern: Pattern 4	1.2	2.9	5.8	2.4	-0.2
Health satisfaction	1.2	1.6	2.5	0.8	-1.6
Mood swings	1.2	2.2	2.4	-1.4	-1.5
Mother’s age at death	1.2	1.5	1.8	-1.3	1.1
Tanning	1.1	13.7	24.7	5.0	-1.7
Supplements: Zinc	1.1	1.2	1.7	0.9	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.9	-1.7	-0.0
Heart attack	1.1	1.4	2.4	1.6	-0.5
Commuting to job workplace: Walk	1.1	1.2	1.6	0.8	-1.3
Pack years of smoking	1.1	1.6	3.0	-0.6	-1.7
Coronary Artery Disease (CAD)	1.0	1.1	2.2	-0.2	-1.5
Diabetes (mother)	1.0	1.2	1.9	0.7	1.4
Medication: Atenolol	1.0	1.3	1.7	1.3	-0.9
Noisy workplace	1.0	1.2	1.2	1.1	-1.1
Qualifications: A levels/AS levels or equivalent	1.0	2.2	3.8	-0.8	2.0
Lung cancer (father)	1.0	1.2	1.6	-1.3	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.1	1.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.1	1.8	-0.2
Number of self-reported non-cancer illnesses	1.0	1.7	2.9	-0.7	-1.7
Miserableness	1.0	1.6	3.3	0.2	-1.8
Medication: Blood pressure	1.0	1.9	2.6	1.1	-1.6
Pain type(s) experienced in last month: Hip pain	1.0	1.3	1.9	1.4	-0.8
Breast Cancer	0.9	2.1	3.6	1.9	-0.8
Prostate Cancer	0.9	1.3	2.5	-1.6	-0.3
Blood White Count	0.9	6.7	8.4	2.9	-2.2
Lung FVC	0.9	4.8	8.9	0.8	-3.0
Hip circumference	0.9	3.7	4.1	2.0	-1.8
Father’s age at death	0.9	1.3	1.8	-0.9	1.3
Eye problems/disorders: Glaucoma	0.9	1.0	1.7	-1.3	-0.6
Alcohol drinker status: Never	0.9	1.0	1.7	-1.3	-0.6
Age started oral contraceptive pill	0.9	1.1	1.7	-1.3	0.7
Ever depressed for a whole week	0.9	1.1	2.2	0.0	1.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	1.9	1.4	-0.6
Schizophrenia vs Biploar Disorder	0.8	1.0	1.8	0.4	-1.4
Lung FEV1/FVC ratio	0.8	3.9	4.5	1.8	-2.1
Sensitivity / hurt feelings	0.8	1.4	2.2	-1.5	0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.0	1.0	-0.9
Falls in the last year	0.8	1.1	1.3	1.1	-0.9
Pulse wave Arterial Stiffness index	0.8	0.9	0.9	0.9	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.4	1.9	-0.9	1.4
Body fat percentage	0.8	3.1	3.9	2.0	-1.5
Medication: Seretide 50 evohaler	0.8	0.9	1.9	0.1	-1.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.7	-0.3	1.3
Osteoarthritis (self-reported)	0.8	1.0	1.4	1.2	-0.7
Medication: Paracetamol	0.8	1.3	2.3	-1.5	-0.5
Alzheimer’s Disease (including proxy)	0.7	1.0	1.9	-0.4	1.4
Fed-up feelings	0.7	1.3	2.5	-0.1	-1.6
Age when periods started (menarche)	0.7	1.7	2.5	1.6	-0.9
Hearing difficulty/problems with background noise	0.7	1.1	1.6	-1.3	-0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.3	0.6	1.1
Illnesses of mother	0.7	0.8	1.2	1.1	-0.7
Exposure to tobacco smoke at home	0.7	0.7	1.3	-0.4	1.1
Breastfed as a baby	0.7	0.8	1.6	1.3	0.3
Medication: Omeprazole	0.7	0.9	1.6	0.4	-1.2
Ever had bowel cancer screening	0.7	0.8	1.6	-1.3	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.5	-1.2	-0.2
Medication: Gliclazide	0.7	0.7	1.2	1.1	0.5
Wears glasses or contact lenses	0.7	0.8	1.4	1.2	-0.5
Depressed Affect (Nagel 2018)	0.6	1.2	1.7	-1.3	-0.8
Fasting Glucose	0.6	0.7	1.0	-0.6	-1.0
Maternal smoking around birth	0.6	0.8	0.9	0.9	-0.9
Supplements: Glucosamine	0.6	0.8	1.5	0.3	-1.2
High blood pressure (mother)	0.6	0.9	1.8	-1.3	-0.1
Waist circumference	0.6	2.2	2.7	1.3	-1.7
Loud music exposure frequency	0.6	0.6	1.2	-1.1	0.3
Glaucoma (self-reported)	0.6	0.7	1.3	-1.2	-0.3
Whole body fat mass	0.6	2.6	2.9	1.7	-1.5
Mean Putamen Volume	0.5	0.6	1.0	-1.0	0.4
Relative age of first facial hair	0.5	0.9	1.8	0.3	1.3
Serious illness, injury or assault to yourself	0.5	0.6	0.9	-0.9	0.6
Weight	0.5	2.6	2.8	1.6	-1.7
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	1.2	0.1
Number of children fathered	0.5	0.6	1.1	1.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	-1.1	0.0
Medication: Ibuprofen	0.5	0.6	0.7	0.7	-0.8
Pulse rate, automated reading	0.5	1.6	2.9	-0.6	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	-0.5	0.9
Average weekly champagne plus white wine intake	0.5	0.7	1.4	1.2	-0.3
Number of operations (self-reported)	0.5	0.8	1.5	0.2	1.2
Irritability	0.5	0.8	1.3	1.1	-0.5
Lupus	0.4	0.6	1.1	0.2	1.0
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	0.9	-0.4
Taking other prescription medications	0.4	0.6	1.2	0.2	-1.1
Had menopause	0.4	0.5	1.0	0.0	-1.0
Pain all over the body in last month	0.4	0.4	0.6	0.5	0.8
Asthma	0.4	0.7	1.1	1.0	-0.6
Peak expiratory flow (PEF)	0.4	0.9	1.7	-1.3	-0.3
Medication for pain relief, constipation, heartburn	0.4	0.7	0.9	1.0	0.7
Heart disease (mother)	0.4	0.5	0.7	0.4	0.9
Overall health rating	0.4	0.9	1.7	-0.2	-1.3
Age at last live birth	0.4	0.5	0.5	-0.7	-0.7
Medication: Atorvastatin	0.4	0.5	0.9	0.9	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	-0.9	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.1	-1.0
Pain experienced in last month	0.4	0.7	0.8	-0.9	0.8
Alcohol drinker status: Previous	0.4	0.5	0.8	0.9	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.2	0.8
Reaction Time	0.3	0.5	0.8	0.9	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	-1.0	0.5
Had other major operations	0.3	0.4	0.6	0.4	0.8
Financial difficulties in last 2 years	0.3	0.4	0.5	0.5	-0.7
Allergy	0.3	0.7	0.7	0.9	-0.8
Medication: Simvastatin	0.3	0.4	0.8	0.9	-0.0
Medication: Lansoprazole	0.3	0.3	0.3	-0.6	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.2	-0.9
Wheeze or whistling in the chest in last year	0.3	0.6	1.0	-1.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.0	-1.0	0.6
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.3	-0.9
Supplements: Calcium	0.3	0.3	0.5	-0.2	0.7
Heart disease (siblings)	0.3	0.4	0.7	-0.3	0.8
Triglycerides	0.2	0.4	0.7	0.8	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.3	-0.4	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.7	-0.2
Medication for hormone replacement therapy	0.2	0.2	0.4	0.6	-0.2
Vitamin and mineral supplements	0.2	0.3	0.4	-0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	0.7	0.2
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.6	0.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	0.6	0.2
Age at first live birth	0.2	0.4	0.8	-0.9	0.2
Neck or shoulder pain in last month	0.2	0.3	0.5	0.4	-0.7
Mean time to correctly identify matches	0.2	0.4	0.6	0.8	-0.3
Number of full sisters	0.2	0.2	0.4	0.6	0.1
Supplements: Vitamin C	0.2	0.3	0.3	-0.5	-0.5
Illnesses of siblings: Diabetes	0.2	0.3	0.5	0.7	0.1
Average weekly red wine intake	0.2	0.3	0.5	0.7	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.7	-0.1
Breast cancer (self-reported)	0.2	0.2	0.2	-0.4	0.5
Asthma (self-reported)	0.2	0.4	0.7	0.8	-0.5
Cholesterol lowering medication	0.2	0.3	0.6	0.8	0.1
Arm predicted mass (left)	0.2	0.8	1.1	0.7	-1.1
Allergy or Eczema	0.1	0.2	0.3	-0.1	0.5
Respiratory disease	0.1	0.1	0.2	0.5	0.2
Medication: Co-codamol	0.1	0.1	0.1	0.3	0.3
Leg fat-free mass (left)	0.1	0.8	0.9	1.0	-0.8
Trunk fat percentage	0.1	0.3	0.3	0.4	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	-0.3
Leg predicted mass (left)	0.1	0.8	1.0	1.0	-0.7
Trunk fat mass	0.1	0.3	0.4	0.4	-0.6
Number of live births	0.1	0.2	0.4	-0.0	0.6
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.5	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.1	-0.5
High blood pressure (siblings)	0.1	0.1	0.1	0.3	-0.3
Arm fat-free mass (right)	0.1	0.5	0.7	0.5	-0.9
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.1	-0.4
Angina (self-reported)	0.1	0.1	0.1	-0.3	-0.4
Arm predicted mass (right)	0.1	0.3	0.4	0.4	-0.7
Alcohol intake frequency.	0.1	0.3	0.5	-0.7	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	0.3	-0.1
Medication: Aspirin	0.1	0.1	0.1	0.4	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.1	0.4
Leg fat-free mass (right)	0.1	0.6	0.8	0.6	-0.9
Loneliness, isolation	0.1	0.1	0.3	-0.5	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.4	-0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	-0.3	0.2
Leg predicted mass (right)	0.1	0.6	0.8	0.7	-0.9
Basal metabolic rate	0.1	0.3	0.5	0.4	-0.7
Arm fat-free mass (left)	0.1	0.5	0.8	0.4	-0.9
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.4	0.2
Alzheimer’s Disease (in father)	0.0	0.0	0.0	0.2	-0.1
Ovarian Cancer	0.0	0.0	0.1	-0.1	-0.3
Hypothyroidism (self reported)	0.0	0.1	0.1	-0.2	-0.3
Hair Pigment	0.0	1.3	1.6	1.0	-1.2
Angina	0.0	0.0	0.1	-0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.2	-0.0
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.1	0.2
Mouth/teeth dental problems	0.0	0.1	0.1	-0.3	-0.2
Illnesses of siblings	0.0	0.0	0.1	0.1	0.2
Trunk fat-free mass	0.0	0.2	0.3	-0.6	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.1	0.2	-0.3
Trunk predicted mass	0.0	0.2	0.3	-0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.1	-0.1
Illnesses of father: Heart disease	0.0	0.0	0.0	-0.1	-0.1
Whole body fat-free mass	0.0	0.1	0.2	0.0	-0.4
Medication: Aspirin	0.0	0.0	0.0	0.2	-0.1
Whole body water mass	0.0	0.1	0.2	0.2	-0.5
Commuting to job workplace: Public transport	0.0	0.1	0.1	0.2	0.2
Risk taking	0.0	0.0	0.0	-0.1	0.2

Hub : Genes

MUSTN1

Models

Trait associations