Hub : Genes

MUSTN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1530 0.0510 2.7e-08 0.137 NA 0.099 NA 0.112 5.3e-08 NA 4.3e-06 NA 9.5e-07
2 YFS Blood 0.0989 0.0325 2.9e-11 0.030 0.04 0.048 0.04 0.042 4.1e-10 4.2e-13 2.8e-15 3.6e-13 1.1e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 10.9 17.3 18.9 -4.0 4.3
Bipolar Disorder or Schizophrenia 14.3 34.8 38.0 -6.2 5.6
Depressed Affect (Nagel 2018) 0.6 1.2 1.7 -1.3 -0.8
Depression (Nagel 2018) 3.3 5.0 7.4 -2.7 1.6
Intelligence (Savage-Jansen 2018) 5.1 15.7 31.5 5.6 -0.1
Neuroticism (Nagel 2018) 4.7 11.0 20.4 -4.5 1.2
Schizophrenia (2018) 8.7 18.0 22.5 -4.7 3.7
Schizophrenia vs Biploar Disorder 0.8 1.0 1.8 0.4 -1.4
Worry (Nagel 2018) 12.7 26.9 48.1 -6.9 2.4
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 -0.2 0.8
Alzheimer’s Disease (in father) 0.0 0.0 0.0 0.2 -0.1
Alzheimer’s Disease (including proxy) 0.7 1.0 1.9 -0.4 1.4
Crohns Disease (2017) 2.9 6.3 7.9 -2.2 2.8
Irritable Bowel Disease (IBD) 2.3 5.5 8.7 -3.0 1.5
Ulcerative Colitis (UC) 1.3 2.4 4.4 -2.1 -0.7
Major Depression (MDD) 4.2 5.1 9.2 -3.0 1.0
Reaction Time 0.3 0.5 0.8 0.9 -0.5
Verbal and Numeric Reasoning (VNR) 5.4 12.9 25.5 5.0 0.6
Breast Cancer 0.9 2.1 3.6 1.9 -0.8
Ovarian Cancer 0.0 0.0 0.1 -0.1 -0.3
Prostate Cancer 0.9 1.3 2.5 -1.6 -0.3
Age at First Birth 1.5 2.2 4.2 2.1 -0.5
Bipolar Disorder (2011) 18.8 18.2 21.2 -4.6 3.9
Body Mass Index (BMI) (2010) 1.5 2.1 4.1 2.0 -0.2
Coronary Artery Disease (CAD) 1.0 1.1 2.2 -0.2 -1.5
Crohns Disease (2012) 4.2 6.8 10.3 -1.8 3.2
Mean Putamen Volume 0.5 0.6 1.0 -1.0 0.4
Fasting Glucose 0.6 0.7 1.0 -0.6 -1.0
HbA1C 2.4 2.7 4.4 1.0 -2.1
HDL Cholesterol 3.5 5.9 9.9 -1.4 3.1
LDL Cholesterol 4.0 6.3 10.2 3.2 -1.5
Lupus 0.4 0.6 1.1 0.2 1.0
Neuroticism (2016) 3.6 5.3 8.0 -2.8 1.6
Primary Biliary Cirrhosis 1.4 2.0 3.3 1.8 -0.8
Rheumatoid Arthritis 1.2 1.6 2.7 1.6 -0.7
Schizophrenia (2014) 9.0 19.9 25.6 -5.1 3.8
Triglycerides 0.2 0.4 0.7 0.8 -0.3
Type 2 Diabetes (T2D) (2012) 2.5 2.9 3.7 1.4 -1.9
Ulcerative Colitis 3.1 4.5 8.8 -3.0 -0.5
Blood Eosinophil Count 4.9 37.4 48.7 7.0 -5.1
Blood Platelet Count 1.7 19.8 21.5 4.2 -4.6
Blood Red Count 2.6 25.4 47.7 -6.9 1.7
Blood White Count 0.9 6.7 8.4 2.9 -2.2
Heel T-Score 2.9 23.3 24.6 5.0 -4.7
BMI 8.4 48.9 67.7 8.2 -5.5
Height 6.3 121.8 166.4 -12.9 8.8
Waist Hip Ratio (WHR) 2.5 11.4 16.6 -4.1 2.5
Systolic Blood Pressure 2.2 10.8 14.9 2.6 -3.9
Smoking Status 7.3 17.5 27.2 5.2 -2.8
Allergy or Eczema 0.1 0.2 0.3 -0.1 0.5
Cardiovascular Disease 3.0 10.0 12.1 3.5 -2.8
Hypothyroidism (self reported) 0.0 0.1 0.1 -0.2 -0.3
Respiratory disease 0.1 0.1 0.2 0.5 0.2
Type 2 Diabetes (T2D) (2018) 4.4 8.2 12.5 3.5 -2.0
Lung FEV1/FVC ratio 0.8 3.9 4.5 1.8 -2.1
Lung FVC 0.9 4.8 8.9 0.8 -3.0
Neuroticism 4.4 10.6 18.8 -4.3 1.6
Chronotype (morning person) 2.7 6.2 9.1 1.8 -3.0
Hair Pigment 0.0 1.3 1.6 1.0 -1.2
Tanning 1.1 13.7 24.7 5.0 -1.7
Hand grip strength (left) 5.4 14.2 17.4 -4.2 3.3
Number of treatments/medications taken 3.4 6.0 9.6 1.6 -3.1
Average weekly spirits intake 3.2 3.9 7.2 2.7 -0.8
Sensitivity / hurt feelings 0.8 1.4 2.2 -1.5 0.8
Frequency of depressed mood in last 2 weeks 2.3 3.2 5.8 -2.4 0.7
Hearing difficulty/problems: Yes 1.5 2.2 3.9 0.8 -2.0
Relative age of first facial hair 0.5 0.9 1.8 0.3 1.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.3 -0.4 0.6
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.5 0.7 -0.2
Ever had hysterectomy (womb removed) 0.4 0.5 0.8 0.9 -0.4
Systolic blood pressure, automated reading 4.3 12.6 21.7 1.8 -4.7
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.0 1.0 -0.9
Angina 0.0 0.0 0.1 -0.1 -0.2
Medication for hormone replacement therapy 0.2 0.2 0.4 0.6 -0.2
Vitamin and mineral supplements 0.2 0.3 0.4 -0.6 -0.6
Supplements: Zinc 1.1 1.2 1.7 0.9 -1.3
Medication: Co-codamol 0.1 0.1 0.1 0.3 0.3
Medication: Metformin 1.4 2.0 3.2 1.8 -0.9
Diabetes (father) 1.2 1.5 2.9 1.7 -0.4
Diabetes (mother) 1.0 1.2 1.9 0.7 1.4
Severe depression (siblings) 1.6 1.7 2.2 -1.1 1.5
Pack years adult smoking proportion 1.4 2.2 4.2 -0.5 -2.0
Impedance of leg (right) 5.0 24.4 25.4 -5.0 4.8
Leg fat-free mass (left) 0.1 0.8 0.9 1.0 -0.8
Trunk fat percentage 0.1 0.3 0.3 0.4 -0.6
Hand grip strength (right) 3.8 10.4 11.7 -3.4 3.0
Townsend deprivation index at recruitment 5.0 7.0 10.4 3.2 -1.9
Current tobacco smoking 1.2 2.0 3.3 1.8 -0.8
Average weekly fortified wine intake 3.3 3.8 3.8 -2.0 2.0
Maternal smoking around birth 0.6 0.8 0.9 0.9 -0.9
Fed-up feelings 0.7 1.3 2.5 -0.1 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 2.9 -1.7 -0.0
Relative age voice broke 2.0 3.0 5.7 2.4 0.5
Taking other prescription medications 0.4 0.6 1.2 0.2 -1.1
Age when periods started (menarche) 0.7 1.7 2.5 1.6 -0.9
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.5 0.7 0.2
Heel bone mineral density (BMD) T-score, automated (left) 3.3 7.4 8.3 2.6 -2.9
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.4 -0.3
Qualifications: CSEs or equivalent 0.2 0.2 0.4 -0.6 0.2
Serious illness, injury or assault to yourself 0.5 0.6 0.9 -0.9 0.6
High blood pressure 2.1 5.8 9.0 1.6 -3.0
Hayfever, allergic rhinitis or eczema 0.3 0.6 0.9 -1.0 0.5
Multivitamins +/- minerals 1.8 2.3 4.4 2.1 0.3
Stomach or abdominal pain in last month 2.0 2.5 3.9 -2.0 1.1
Supplements: Glucosamine 0.6 0.8 1.5 0.3 -1.2
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 0.2 -0.0
Medication: Atenolol 1.0 1.3 1.7 1.3 -0.9
Medication: Levothyroxine sodium 0.0 0.0 0.0 0.1 0.2
Sitting height 4.8 34.0 53.3 -7.3 3.8
Chronic bronchitis/emphysema (father) 1.3 1.5 3.1 0.0 1.8
High blood pressure (mother) 0.6 0.9 1.8 -1.3 -0.1
Body mass index (BMI) 6.8 28.9 32.9 5.7 -5.0
Impedance of leg (left) 5.0 24.1 28.2 -5.3 4.5
Leg predicted mass (left) 0.1 0.8 1.0 1.0 -0.7
Trunk fat mass 0.1 0.3 0.4 0.4 -0.6
Waist circumference 0.6 2.2 2.7 1.3 -1.7
Number of incorrect matches in round 7.3 12.2 16.6 -4.1 2.8
Past tobacco smoking 5.2 9.5 16.3 -4.0 1.7
Alcohol usually taken with meals 4.7 7.7 9.1 -2.5 3.0
Nervous feelings 8.1 15.1 25.8 -5.1 2.1
Frequency of tenseness / restlessness in last 2 weeks 3.2 5.0 10.0 -3.2 0.1
Hearing difficulty/problems with background noise 0.7 1.1 1.6 -1.3 -0.7
Hair/balding pattern: Pattern 2 0.2 0.2 0.4 0.6 0.2
Had menopause 0.4 0.5 1.0 0.0 -1.0
Had other major operations 0.3 0.4 0.6 0.4 0.8
Forced vital capacity (FVC) 2.6 9.9 19.5 -4.4 0.5
Heel bone mineral density (BMD) T-score, automated (right) 4.1 9.4 11.0 2.8 -3.3
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.3 0.6 1.1
Qualifications: None of the above 4.0 8.6 12.9 2.1 -3.6
Financial difficulties in last 2 years 0.3 0.4 0.5 0.5 -0.7
Mouth/teeth dental problems 0.0 0.1 0.1 -0.3 -0.2
Heart attack 1.1 1.4 2.4 1.6 -0.5
Allergy 0.3 0.7 0.7 0.9 -0.8
Pain all over the body in last month 0.4 0.4 0.6 0.5 0.8
Diabetes (self-reported) 4.8 7.4 10.8 3.3 -2.0
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 3.0 -1.7 -0.4
Medication: Ramipril 1.9 2.4 4.2 0.8 -2.0
Medication: Simvastatin 0.3 0.4 0.8 0.9 -0.0
Fluid intelligence score 4.2 8.8 15.4 3.9 1.5
Illnesses of siblings 0.0 0.0 0.1 0.1 0.2
Neuroticism score 1.9 3.9 7.7 -2.8 -0.1
Weight 0.5 2.6 2.8 1.6 -1.7
Impedance of arm (right) 7.6 35.2 39.3 -6.3 5.6
Arm fat percentage (right) 2.5 9.8 11.4 3.4 -2.9
Trunk fat-free mass 0.0 0.2 0.3 -0.6 0.1
Hip circumference 0.9 3.7 4.1 2.0 -1.8
Time employed in main current job 1.8 2.1 2.3 1.3 -1.5
Alcohol intake versus 10 years previously 3.1 4.6 7.0 2.6 -1.5
Father’s age at death 0.9 1.3 1.8 -0.9 1.3
Worrier / anxious feelings 12.9 24.4 43.2 -6.6 2.4
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.2 4.3 -2.1 0.3
Falls in the last year 0.8 1.1 1.3 1.1 -0.9
Hair/balding pattern: Pattern 3 0.5 0.8 1.6 1.2 0.1
Number of live births 0.1 0.2 0.4 -0.0 0.6
Forced expiratory volume in 1-second (FEV1) 1.7 5.8 11.2 -3.4 0.6
Pulse rate 2.4 4.1 6.0 -2.4 1.5
Happiness 6.3 7.7 8.1 -2.7 2.9
Noisy workplace 1.0 1.2 1.2 1.1 -1.1
Qualifications: A levels/AS levels or equivalent 1.0 2.2 3.8 -0.8 2.0
Serious illness, injury or assault of a close relative in last 2 years 4.3 5.0 7.6 -1.5 2.8
Mouth/teeth dental problems: Dentures 1.2 2.0 3.3 0.8 -1.8
Asthma 0.4 0.7 1.1 1.0 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.1 0.1 0.2 -0.3
Medication: Cholesterol lowering 1.4 2.2 3.9 2.0 -0.8
Depression (self-reported) 3.8 4.6 9.2 -3.0 0.0
Medication: Lansoprazole 0.3 0.3 0.3 -0.6 0.6
Prospective memory result 4.0 4.9 8.1 -2.9 1.3
Lung cancer (father) 1.0 1.2 1.6 -1.3 -0.9
Illnesses of mother 0.7 0.8 1.2 1.1 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.9 11.6 -3.4 0.5
Pulse wave Arterial Stiffness index 0.8 0.9 0.9 0.9 -1.0
Impedance of arm (left) 7.2 33.4 38.2 -6.2 5.3
Arm fat mass (right) 1.8 7.3 8.0 2.8 -2.6
Trunk predicted mass 0.0 0.2 0.3 -0.5 0.1
Standing height 6.6 65.3 79.7 -8.9 7.1
Length of working week for main job 1.5 1.7 3.1 1.8 -0.5
Exposure to tobacco smoke at home 0.7 0.7 1.3 -0.4 1.1
Breastfed as a baby 0.7 0.8 1.6 1.3 0.3
Tense / ‘highly strung’ 5.2 8.6 14.1 -3.8 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 4.0 6.2 9.8 -3.1 1.6
Hair/balding pattern: Pattern 4 1.2 2.9 5.8 2.4 -0.2
Birth weight of first child 1.9 3.5 5.8 -1.1 2.4
Peak expiratory flow (PEF) 0.4 0.9 1.7 -1.3 -0.3
Pulse wave reflection index 1.9 2.3 4.6 2.1 -0.0
Ever highly irritable/argumentative for 2 days 4.5 5.4 9.6 3.1 -1.1
Loud music exposure frequency 0.6 0.6 1.2 -1.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.4 1.9 -0.9 1.4
Mouth/teeth dental problems: Bleeding gums 2.7 3.5 4.1 -1.7 2.0
Blood clot in the leg (DVT) 0.1 0.1 0.2 -0.5 0.1
Medication: Paracetamol 1.4 2.4 4.6 -2.1 0.4
Headache pain in last month 6.9 11.9 16.1 -4.0 2.8
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 3.6 -1.6 1.9
Glaucoma (self-reported) 0.6 0.7 1.3 -1.2 -0.3
Gout (self-reported) 4.6 6.4 7.8 -2.2 -2.8
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 0.1 -0.1
Medication: Amlodipine 1.6 2.2 4.1 0.6 -2.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 -0.2 -0.9
Birth weight 2.2 4.8 7.0 -2.6 1.6
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.3 0.1 -0.5
High blood pressure (siblings) 0.1 0.1 0.1 0.3 -0.3
Forced vital capacity (FVC), Best measure 2.9 10.6 20.7 -4.5 0.7
Body fat percentage 0.8 3.1 3.9 2.0 -1.5
Leg fat percentage (right) 3.1 11.2 15.3 3.9 -2.6
Arm fat-free mass (right) 0.1 0.5 0.7 0.5 -0.9
Exposure to tobacco smoke outside home 0.1 0.1 0.2 -0.1 -0.4
Comparative body size at age 10 2.3 6.5 11.5 3.4 -1.2
Number of full brothers 1.5 1.9 3.3 1.8 0.7
Worry too long after embarrassment 1.6 2.8 5.1 -2.3 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 3.2 4.1 7.8 -2.8 0.7
Wheeze or whistling in the chest in last year 0.3 0.6 1.0 -1.0 -0.3
Number of children fathered 0.5 0.6 1.1 1.1 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 3.6 -0.9 1.9
Age at first live birth 0.2 0.4 0.8 -0.9 0.2
Pulse wave peak to peak time 1.8 2.1 2.2 -1.5 1.4
Health satisfaction 1.2 1.6 2.5 0.8 -1.6
Shortness of breath walking on level ground 3.4 4.0 6.6 1.2 -2.6
Qualifications: College or University degree 3.4 10.6 14.6 -2.6 3.8
Eye problems/disorders: None of the above 1.7 1.9 3.7 1.9 0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.2 -1.1 0.0
Emphysema/chronic bronchitis 1.4 1.6 1.6 -1.3 1.3
Medication for pain relief, constipation, heartburn 0.4 0.7 0.9 1.0 0.7
Neck or shoulder pain in last month 0.2 0.3 0.5 0.4 -0.7
Medication: Blood pressure 2.1 3.6 5.4 1.4 -2.3
Angina (self-reported) 0.1 0.1 0.1 -0.3 -0.4
Migraine (self-reported) 2.9 3.7 5.6 -2.4 1.3
Medication: Ibuprofen 0.5 0.6 0.7 0.7 -0.8
Medication: Allopurinol 3.5 4.7 7.4 -1.4 -2.7
Medication: Omeprazole 0.7 0.9 1.6 0.4 -1.2
Medication: Seretide 50 evohaler 0.8 0.9 1.9 0.1 -1.4
Mean time to correctly identify matches 0.2 0.4 0.6 0.8 -0.3
Heart disease (mother) 0.4 0.5 0.7 0.4 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.1 1.5 -0.5
Whole body fat mass 0.6 2.6 2.9 1.7 -1.5
Leg fat mass (right) 2.0 7.8 10.3 3.2 -2.3
Arm predicted mass (right) 0.1 0.3 0.4 0.4 -0.7
Pulse rate, automated reading 0.5 1.6 2.9 -0.6 1.7
Alcohol intake frequency. 0.1 0.3 0.5 -0.7 -0.3
Comparative height size at age 10 4.4 24.5 31.9 -5.7 4.1
Number of full sisters 0.2 0.2 0.4 0.6 0.1
Suffer from ‘nerves’ 3.9 6.2 11.8 -3.4 0.8
Overall health rating 0.4 0.9 1.7 -0.2 -1.3
Chest pain or discomfort 2.9 4.1 5.7 -2.4 1.6
Had major operations 1.3 1.5 2.4 1.6 0.7
Age at last live birth 0.4 0.5 0.5 -0.7 -0.7
Family relationship satisfaction 4.4 5.4 6.4 -2.5 2.1
Leg pain on walking 1.8 2.3 3.2 1.2 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 0.9 -0.5 0.9
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.7 -0.3 1.3
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 0.3 -0.1
Medication: Aspirin 0.1 0.1 0.1 0.4 0.0
Supplements: Vitamin C 0.2 0.3 0.3 -0.5 -0.5
Knee pain experienced in last month 2.0 3.1 3.7 1.9 -1.6
Hypertension (Self-reported) 2.5 6.8 10.1 1.9 -3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.1 0.4
Illnesses of father: Heart disease 0.0 0.0 0.0 -0.1 -0.1
Illnesses of siblings: Diabetes 0.2 0.3 0.5 0.7 0.1
Smoking status: Previous 3.7 5.6 9.9 3.2 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 4.4 9.2 14.4 -3.8 2.0
Whole body fat-free mass 0.0 0.1 0.2 0.0 -0.4
Leg fat-free mass (right) 0.1 0.6 0.8 0.6 -0.9
Arm fat percentage (left) 2.3 9.2 10.1 3.2 -2.9
Average weekly red wine intake 0.2 0.3 0.5 0.7 0.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.5 -0.7 -0.1
Mood swings 1.2 2.2 2.4 -1.4 -1.5
Loneliness, isolation 0.1 0.1 0.3 -0.5 -0.1
Long-standing illness, disability or infirmity 2.2 3.4 4.3 1.6 -2.1
Ever had bowel cancer screening 0.7 0.8 1.6 -1.3 0.0
Diabetes diagnosed by doctor 5.0 8.1 12.1 3.5 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.4 1.9 1.0 -1.4
Friendships satisfaction 4.3 5.3 7.0 -2.6 1.9
Qualifications: nursing, teaching 3.5 5.5 11.0 0.1 3.3
Commuting to job workplace: Walk 1.1 1.2 1.6 0.8 -1.3
Eye problems/disorders: Cataract 1.5 1.8 2.9 -1.7 0.8
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 3.1 1.8 -0.2
Medication for cholesterol 1.5 2.3 3.8 -2.0 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.5 -1.2 -0.2
Back pain experienced in last month 1.6 2.3 2.6 1.6 -1.4
Mineral and other dietary supplements 2.7 3.6 4.9 -2.2 1.5
Breast cancer (self-reported) 0.2 0.2 0.2 -0.4 0.5
Asthma (self-reported) 0.2 0.4 0.7 0.8 -0.5
Osteoporosis (self-reported) 0.1 0.1 0.1 -0.4 -0.0
Osteoarthritis (self-reported) 0.8 1.0 1.4 1.2 -0.7
Medication: Aspirin 0.0 0.0 0.0 0.2 -0.1
Medication: Gliclazide 0.7 0.7 1.2 1.1 0.5
Illnesses of father: None of the above (group 1) 0.1 0.1 0.1 -0.3 0.2
Smoking status: Current 1.9 3.0 4.8 2.2 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.0 -1.0 0.6
Whole body water mass 0.0 0.1 0.2 0.2 -0.5
Leg predicted mass (right) 0.1 0.6 0.8 0.7 -0.9
Arm fat mass (left) 2.0 8.1 8.7 3.0 -2.7
Number of self-reported non-cancer illnesses 1.0 1.7 2.9 -0.7 -1.7
Average weekly champagne plus white wine intake 0.5 0.7 1.4 1.2 -0.3
Miserableness 1.0 1.6 3.3 0.2 -1.8
Guilty feelings 2.4 3.6 7.0 -2.6 0.5
Wears glasses or contact lenses 0.7 0.8 1.4 1.2 -0.5
Ever taken oral contraceptive pill 1.5 1.7 2.8 1.7 -0.8
Hearing aid user 6.8 7.7 11.1 2.0 -3.3
Mother’s age at death 1.2 1.5 1.8 -1.3 1.1
Financial situation satisfaction 1.8 2.3 3.6 1.0 -1.9
Tinnitus: Yes, now most or all of the time 1.6 1.9 2.6 -1.6 -1.1
Commuting to job workplace: Public transport 0.0 0.1 0.1 0.2 0.2
Eye problems/disorders: Glaucoma 0.9 1.0 1.7 -1.3 -0.6
Medication: Blood pressure 1.0 1.9 2.6 1.1 -1.6
Pain type(s) experienced in last month: Hip pain 1.0 1.3 1.9 1.4 -0.8
Supplements: Fish oil (including cod liver oil) 2.4 3.2 3.2 1.8 -1.8
High cholesterol (Self-reported) 1.9 3.4 3.8 1.7 -2.0
Medication: Bendroflumethiazide 1.7 2.6 3.1 1.4 -1.8
Medication: Paracetamol 0.8 1.3 2.3 -1.5 -0.5
Medication: Lisinopril 1.8 2.3 3.3 1.2 -1.8
Medication: Atorvastatin 0.4 0.5 0.9 0.9 -0.4
Illnesses of father: High blood pressure 1.4 1.8 3.1 -0.6 -1.8
Alcohol drinker status: Never 0.9 1.0 1.7 -1.3 -0.6
Ever smoked 4.3 7.5 13.3 3.7 -1.3
Basal metabolic rate 0.1 0.3 0.5 0.4 -0.7
Leg fat percentage (left) 3.5 12.8 15.4 3.9 -3.2
Arm fat-free mass (left) 0.1 0.5 0.8 0.4 -0.9
Number of operations (self-reported) 0.5 0.8 1.5 0.2 1.2
Average weekly beer plus cider intake 0.1 0.1 0.2 -0.5 0.2
Irritability 0.5 0.8 1.3 1.1 -0.5
Risk taking 0.0 0.0 0.0 -0.1 0.2
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.8 -0.9 0.3
Fractured/broken bones in last 5 years 1.6 2.1 3.6 0.8 -1.9
Age started oral contraceptive pill 0.9 1.1 1.7 -1.3 0.7
Diastolic blood pressure, automated reading 1.6 5.1 9.4 -0.9 -3.1
Ever depressed for a whole week 0.9 1.1 2.2 0.0 1.5
Unable to work because of sickness or disability 0.3 0.4 0.8 -0.3 -0.9
Commuting to job workplace: Cycle 1.3 1.6 3.0 0.5 -1.7
Myopia 2.5 3.6 6.8 2.6 0.6
Vascular/heart problems diagnosed by doctor 2.0 5.4 7.9 -1.7 2.8
Cholesterol lowering medication 0.2 0.3 0.6 0.8 0.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 -0.1 -1.0
Pain experienced in last month 0.4 0.7 0.8 -0.9 0.8
Supplements: Calcium 0.3 0.3 0.5 -0.2 0.7
Basal cell carcinoma (self-reported) 4.1 4.9 5.9 -2.4 2.0
Heart attack/myocardial infarction (self-reported) 0.9 1.2 1.9 1.4 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 -0.4 0.2
Heart disease (siblings) 0.3 0.4 0.7 -0.3 0.8
Alcohol drinker status: Previous 0.4 0.5 0.8 0.9 0.4
Pack years of smoking 1.1 1.6 3.0 -0.6 -1.7
Impedance of whole body 7.3 37.2 44.6 -6.7 5.5
Leg fat mass (left) 2.2 8.5 10.1 3.2 -2.6
Arm predicted mass (left) 0.2 0.8 1.1 0.7 -1.1