Best TWAS P=2.3e-36 · Best GWAS P=7.17e-48 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | IFT122 | 0.17 | 0.20 | lasso | 2 | 0.20 | 1.3e-23 | 7.29 | -7.3 | 2.9e-13 | 0.15 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | LOC100507032 | 0.08 | 0.06 | enet | 14 | 0.08 | 4.6e-10 | -10.35 | 12.4 | 1.7e-35 | -0.69 | 1.00 | 0.00 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | PLXND1 | 0.10 | 0.03 | bslmm | 294 | 0.06 | 1.8e-07 | -11.42 | 8.7 | 5.3e-18 | -0.46 | 0.94 | 0.03 | FALSE |
4 | CommonMind | Brain Pre-frontal Cortex | RPL32P3 | 0.23 | 0.18 | enet | 13 | 0.19 | 9.6e-23 | 4.66 | -5.2 | 1.6e-07 | 0.09 | 1.00 | 0.00 | FALSE |
5 | CommonMind | Brain Pre-frontal Cortex | TMCC1 | 0.11 | 0.08 | lasso | 3 | 0.08 | 1.0e-09 | -8.02 | 7.8 | 7.7e-15 | -0.66 | 1.00 | 0.00 | FALSE |
6 | GTEx | Adrenal Gland | RPL32P3 | 0.13 | 0.04 | lasso | 10 | 0.02 | 8.5e-02 | 2.99 | 5.4 | 5.3e-08 | -0.19 | 0.06 | 0.24 | FALSE |
7 | GTEx | Artery Aorta | PLXND1 | 0.12 | 0.01 | lasso | 3 | 0.01 | 1.5e-01 | -14.18 | 12.6 | 2.3e-36 | -0.84 | 0.04 | 0.36 | TRUE |
8 | GTEx | Brain Caudate basal ganglia | IFT122 | 0.38 | 0.01 | enet | 19 | 0.19 | 3.1e-06 | 4.66 | -7.2 | 8.0e-13 | 0.07 | 0.12 | 0.05 | FALSE |
9 | GTEx | Brain Cortex | COPG1 | 0.24 | 0.00 | enet | 57 | 0.03 | 5.3e-02 | 4.27 | 9.6 | 1.1e-21 | -0.31 | 0.04 | 0.26 | FALSE |
10 | GTEx | Brain Frontal Cortex BA9 | IFT122 | 0.25 | 0.13 | lasso | 6 | 0.16 | 5.1e-05 | 7.28 | -7.3 | 3.6e-13 | 0.17 | 0.31 | 0.06 | FALSE |
11 | GTEx | Brain Nucleus accumbens basal ganglia | IFT122 | 0.27 | 0.22 | lasso | 3 | 0.21 | 3.0e-06 | 6.69 | -6.7 | 2.5e-11 | 0.18 | 0.13 | 0.05 | TRUE |
12 | GTEx | Cells Transformed fibroblasts | IFT122 | 0.09 | 0.05 | lasso | 4 | 0.06 | 1.8e-05 | 6.44 | -8.7 | 2.7e-18 | 0.28 | 0.68 | 0.05 | FALSE |
13 | GTEx | Colon Transverse | HMCES | 0.18 | 0.01 | enet | 15 | 0.06 | 9.3e-04 | -1.48 | 6.0 | 2.4e-09 | -0.35 | 0.04 | 0.40 | FALSE |
14 | GTEx | Colon Transverse | RPL32P3 | 0.19 | 0.00 | lasso | 7 | 0.00 | 4.8e-01 | -8.02 | 12.3 | 1.4e-34 | -0.56 | 0.04 | 0.29 | FALSE |
15 | GTEx | Lung | H1FX | 0.21 | 0.06 | enet | 5 | 0.09 | 1.9e-07 | 4.66 | 6.1 | 1.1e-09 | -0.08 | 1.00 | 0.00 | FALSE |
16 | GTEx | Lung | H1FX-AS1 | 0.18 | 0.01 | lasso | 5 | 0.02 | 7.7e-03 | 4.66 | 6.2 | 7.0e-10 | -0.08 | 0.98 | 0.00 | FALSE |
17 | GTEx | Nerve Tibial | PLXND1 | 0.12 | 0.03 | enet | 15 | 0.05 | 9.9e-05 | -10.42 | 7.6 | 2.6e-14 | -0.30 | 0.16 | 0.07 | FALSE |
18 | GTEx | Nerve Tibial | RPL32P3 | 0.23 | 0.02 | lasso | 11 | 0.03 | 2.3e-03 | 6.26 | 5.8 | 4.9e-09 | -0.15 | 0.34 | 0.05 | TRUE |
19 | GTEx | Pancreas | IFT122 | 0.21 | 0.07 | enet | 15 | 0.04 | 6.9e-03 | 7.28 | -5.8 | 8.8e-09 | 0.05 | 0.45 | 0.03 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | IFT122 | 0.10 | 0.05 | lasso | 3 | 0.02 | 4.3e-03 | 7.92 | -8.1 | 7.1e-16 | 0.15 | 0.17 | 0.04 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | TMCC1-AS1 | 0.09 | 0.00 | enet | 10 | 0.02 | 9.4e-03 | -0.14 | 6.0 | 1.7e-09 | -0.29 | 0.03 | 0.52 | FALSE |
22 | GTEx | Testis | IFT122 | 0.21 | 0.16 | enet | 18 | 0.15 | 3.5e-07 | 7.92 | -7.8 | 6.1e-15 | 0.22 | 0.88 | 0.01 | FALSE |
23 | YFS | Blood | H1FX | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-03 | 4.27 | -5.2 | 2.4e-07 | 0.15 | 0.17 | 0.06 | TRUE |
24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPL32P3 | 0.02 | 0.01 | blup | 34 | 0.01 | 7.9e-04 | 5.48 | 5.7 | 1.3e-08 | -0.08 | 0.09 | 0.02 | FALSE |
25 | The Cancer Genome Atlas | Colon Adenocarcinoma | IFT122 | 0.06 | 0.06 | enet | 7 | 0.07 | 4.8e-05 | 7.28 | -7.1 | 1.5e-12 | 0.15 | 0.54 | 0.04 | FALSE |
26 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PLXND1 | 0.06 | 0.01 | enet | 9 | 0.03 | 1.4e-04 | -8.02 | -9.6 | 6.5e-22 | 0.77 | 0.02 | 0.74 | FALSE |
27 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IFT122 | 0.03 | 0.03 | blup | 53 | 0.03 | 3.2e-04 | 7.28 | -7.8 | 8.4e-15 | 0.18 | 0.41 | 0.03 | FALSE |
28 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IFT122 | 0.12 | 0.09 | blup | 53 | 0.08 | 3.9e-05 | 7.28 | -9.2 | 2.3e-20 | 0.30 | 0.76 | 0.10 | FALSE |
29 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IFT122 | 0.18 | 0.13 | blup | 53 | 0.13 | 6.3e-15 | 7.15 | -8.6 | 5.7e-18 | 0.23 | 1.00 | 0.00 | FALSE |
30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MBD4 | 0.02 | 0.01 | blup | 31 | 0.01 | 4.8e-02 | 7.28 | 8.0 | 1.7e-15 | -0.22 | 0.02 | 0.16 | TRUE |
31 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPL32P3 | 0.03 | 0.04 | lasso | 1 | 0.04 | 4.5e-05 | 6.91 | 6.9 | 5.0e-12 | -0.12 | 0.70 | 0.05 | FALSE |
32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TRH | 0.16 | 0.05 | enet | 12 | 0.05 | 1.1e-06 | 2.94 | 5.4 | 8.4e-08 | -0.11 | 0.55 | 0.04 | TRUE |
33 | The Cancer Genome Atlas | Lung Adenocarcinoma | IFT122 | 0.03 | 0.03 | blup | 53 | 0.03 | 8.9e-05 | 5.17 | -5.6 | 2.3e-08 | 0.07 | 0.70 | 0.01 | FALSE |
34 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPL32P3 | 0.07 | 0.00 | blup | 35 | 0.01 | 6.4e-03 | 7.87 | 10.1 | 6.9e-24 | -0.24 | 0.02 | 0.38 | FALSE |
35 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IFT122 | 0.28 | 0.08 | blup | 53 | 0.12 | 1.2e-05 | 6.91 | -8.6 | 6.9e-18 | 0.31 | 0.59 | 0.05 | FALSE |
36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IFT122 | 0.08 | 0.10 | enet | 15 | 0.10 | 5.8e-11 | 7.28 | -9.0 | 3.0e-19 | 0.16 | 1.00 | 0.00 | TRUE |
37 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPL32P3 | 0.04 | 0.03 | blup | 34 | 0.03 | 2.4e-04 | 6.44 | 7.6 | 4.2e-14 | -0.13 | 0.31 | 0.02 | FALSE |
38 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IFT122 | 0.09 | 0.12 | blup | 53 | 0.07 | 1.7e-03 | 7.05 | -9.2 | 4.0e-20 | 0.26 | 0.20 | 0.08 | FALSE |
39 | The Cancer Genome Atlas | Thyroid Carcinoma | IFT122 | 0.11 | 0.10 | lasso | 3 | 0.09 | 2.7e-09 | 7.28 | -7.5 | 9.5e-14 | 0.14 | 1.00 | 0.00 | FALSE |