Hub : Genes

TRH

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Kidney Renal Papillary Cell Carcinoma 0.124 0.0570 8.2e-06 0.121 0.101 0.118 NA 0.118 2.1e-07 2.1e-06 2.8e-07 NA 2.9e-07
2 TCGA Brain Lower Grade Glioma 0.155 0.0591 2.6e-04 0.051 0.038 0.053 NA 0.048 1.9e-06 3.5e-05 1.1e-06 NA 3.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.4 0.6 0.9 -0.6 0.9
Bipolar Disorder or Schizophrenia 1.1 2.7 3.0 -1.7 1.5
Depressed Affect (Nagel 2018) 0.5 1.1 2.1 -0.2 -1.4
Depression (Nagel 2018) 2.1 3.2 6.3 -0.3 -2.5
Intelligence (Savage-Jansen 2018) 1.0 3.0 6.0 -0.3 -2.5
Neuroticism (Nagel 2018) 0.4 1.0 1.9 0.3 -1.4
Schizophrenia (2018) 1.1 2.2 3.0 -1.7 1.2
Schizophrenia vs Biploar Disorder 0.1 0.1 0.1 0.3 -0.2
Worry (Nagel 2018) 0.4 0.8 0.9 1.0 -0.8
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 -0.3 -0.0
Alzheimer’s Disease (in father) 1.6 1.8 3.5 -0.1 -1.9
Alzheimer’s Disease (including proxy) 0.7 0.9 1.9 0.2 -1.4
Crohns Disease (2017) 0.6 1.3 1.9 1.4 0.9
Irritable Bowel Disease (IBD) 0.6 1.5 3.0 1.7 0.1
Ulcerative Colitis (UC) 0.0 0.1 0.2 0.4 -0.0
Major Depression (MDD) 0.9 1.0 1.5 1.2 -0.8
Reaction Time 1.1 2.0 3.5 -0.8 1.9
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.5 -0.0 -1.9
Breast Cancer 2.0 4.7 7.2 1.5 2.7
Ovarian Cancer 0.6 0.8 1.2 0.7 1.1
Prostate Cancer 1.6 2.3 4.5 -2.1 0.3
Age at First Birth 0.7 1.0 1.4 -1.2 0.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 1.5 1.2 0.5
Coronary Artery Disease (CAD) 0.5 0.6 0.9 -0.5 1.0
Crohns Disease (2012) 0.1 0.2 0.4 -0.3 0.6
Mean Putamen Volume 1.4 1.6 3.1 1.8 -0.5
Fasting Glucose 0.3 0.3 0.5 0.7 -0.4
HbA1C 2.3 2.6 5.0 0.4 -2.2
HDL Cholesterol 0.4 0.7 1.3 -1.1 0.0
LDL Cholesterol 0.4 0.6 0.7 -0.7 0.9
Lupus 0.1 0.2 0.2 0.5 -0.5
Neuroticism (2016) 0.2 0.3 0.4 -0.4 -0.7
Primary Biliary Cirrhosis 0.4 0.5 0.6 0.7 0.8
Rheumatoid Arthritis 0.1 0.1 0.2 0.0 -0.4
Schizophrenia (2014) 0.8 1.9 2.2 -1.5 1.2
Triglycerides 0.4 0.7 0.9 0.9 0.7
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.0 -0.4 1.0
Ulcerative Colitis 0.0 0.0 0.1 0.0 -0.3
Blood Eosinophil Count 0.6 4.5 7.1 -2.7 -1.4
Blood Platelet Count 0.2 1.7 3.5 -1.9 0.1
Blood Red Count 0.1 0.6 0.9 -0.6 -0.9
Blood White Count 0.1 0.9 1.6 1.3 -0.3
Heel T-Score 0.1 0.6 0.9 -0.9 -0.5
BMI 0.0 0.0 0.0 -0.1 -0.1
Height 0.4 7.7 13.1 -1.5 -3.6
Waist Hip Ratio (WHR) 3.2 14.5 28.7 0.6 5.4
Systolic Blood Pressure 0.2 0.9 1.2 -0.8 1.1
Smoking Status 0.6 1.4 2.6 1.6 0.4
Allergy or Eczema 0.0 0.0 0.0 -0.0 0.2
Cardiovascular Disease 0.1 0.5 0.8 -0.3 0.9
Hypothyroidism (self reported) 0.2 0.5 0.6 0.7 -0.8
Respiratory disease 0.3 0.8 1.5 -0.2 1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.3 -0.6 0.6
Lung FEV1/FVC ratio 0.0 0.2 0.2 0.4 0.4
Lung FVC 0.1 0.3 0.6 -0.2 0.8
Neuroticism 0.2 0.5 0.8 0.5 -0.9
Chronotype (morning person) 1.6 3.6 6.5 0.8 -2.5
Hair Pigment 0.0 0.1 0.2 0.4 -0.1
Tanning 0.2 2.8 5.7 2.4 -0.1
Hand grip strength (left) 0.1 0.2 0.4 0.6 -0.2
Number of treatments/medications taken 0.2 0.3 0.3 0.6 -0.5
Average weekly spirits intake 0.7 0.9 0.9 -1.0 -0.9
Sensitivity / hurt feelings 0.8 1.3 1.8 -0.9 -1.4
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.9 0.1 -1.4
Hearing difficulty/problems: Yes 1.0 1.5 2.3 -0.9 -1.5
Relative age of first facial hair 1.3 2.8 3.5 -1.9 -1.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.1 0.2 1.0
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.1 -1.1 0.6
Ever had hysterectomy (womb removed) 3.9 4.4 8.5 0.6 2.9
Systolic blood pressure, automated reading 1.8 5.3 6.4 -2.5 2.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 0.5 -0.5
Angina 0.7 0.9 1.5 0.6 1.2
Medication for hormone replacement therapy 0.6 0.7 1.0 -1.0 -0.6
Vitamin and mineral supplements 0.8 1.0 1.5 1.2 -0.7
Supplements: Zinc 0.3 0.4 0.4 -0.6 0.6
Medication: Co-codamol 2.2 2.6 5.1 0.4 -2.3
Medication: Metformin 0.8 1.2 2.4 0.0 1.5
Diabetes (father) 0.0 0.1 0.1 -0.2 0.2
Diabetes (mother) 0.9 1.1 1.2 1.1 -1.0
Severe depression (siblings) 0.2 0.2 0.4 0.1 0.7
Pack years adult smoking proportion 0.1 0.2 0.2 0.4 -0.5
Impedance of leg (right) 0.1 0.4 0.7 -0.8 -0.4
Leg fat-free mass (left) 0.3 1.5 2.9 -0.2 -1.7
Trunk fat percentage 0.5 1.9 3.4 -1.8 -0.7
Hand grip strength (right) 0.1 0.2 0.3 0.6 -0.1
Townsend deprivation index at recruitment 0.8 1.1 2.2 1.5 0.0
Current tobacco smoking 0.7 1.2 1.3 1.2 -1.0
Average weekly fortified wine intake 0.0 0.0 0.1 -0.0 -0.3
Maternal smoking around birth 1.2 1.7 2.9 0.8 -1.7
Fed-up feelings 0.3 0.5 0.9 -0.9 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 4.3 -0.1 -2.1
Relative age voice broke 0.4 0.6 1.2 0.1 -1.1
Taking other prescription medications 0.8 1.2 1.6 1.3 -0.9
Age when periods started (menarche) 0.7 1.7 2.8 -1.7 0.8
Bilateral oophorectomy (both ovaries removed) 2.6 3.0 3.4 1.6 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.0 0.0 0.2 0.1
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.2 -0.0 -1.1
Qualifications: CSEs or equivalent 3.6 4.7 8.9 3.0 -0.8
Serious illness, injury or assault to yourself 0.2 0.2 0.2 -0.4 0.4
High blood pressure 1.2 3.5 6.8 -0.4 2.6
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.7 -0.8 -0.1
Multivitamins +/- minerals 0.5 0.6 1.2 -1.1 0.2
Stomach or abdominal pain in last month 0.2 0.3 0.6 -0.7 0.2
Supplements: Glucosamine 1.5 1.9 3.3 -0.8 1.8
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.1 -1.1 0.7
Medication: Atenolol 1.8 2.2 4.0 2.0 0.6
Medication: Levothyroxine sodium 0.2 0.4 0.7 0.8 0.0
Sitting height 0.5 3.7 6.1 1.1 -2.5
Chronic bronchitis/emphysema (father) 0.3 0.4 0.7 -0.8 -0.1
High blood pressure (mother) 1.0 1.4 1.6 1.1 -1.3
Body mass index (BMI) 0.0 0.1 0.2 -0.5 0.2
Impedance of leg (left) 0.1 0.2 0.3 -0.5 -0.5
Leg predicted mass (left) 0.2 1.3 2.6 -0.1 -1.6
Trunk fat mass 0.3 1.3 1.8 -1.3 -0.9
Waist circumference 0.3 1.2 1.2 -1.1 1.1
Number of incorrect matches in round 0.3 0.5 0.5 -0.7 0.6
Past tobacco smoking 0.1 0.3 0.5 0.7 -0.0
Alcohol usually taken with meals 2.4 3.9 7.2 -2.7 -0.8
Nervous feelings 0.0 0.0 0.0 0.1 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.7 0.4 -0.8
Hearing difficulty/problems with background noise 0.5 0.8 1.3 -0.7 -1.1
Hair/balding pattern: Pattern 2 1.9 2.4 4.8 -2.2 -0.2
Had menopause 2.0 2.4 3.7 -1.9 1.1
Had other major operations 0.7 0.9 1.2 0.8 -1.1
Forced vital capacity (FVC) 0.6 2.3 4.5 -0.3 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.0 0.1 0.2 -0.1
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 2.0 -1.4 -0.6
Qualifications: None of the above 0.9 2.0 4.0 0.0 2.0
Financial difficulties in last 2 years 0.0 0.1 0.1 0.3 -0.2
Mouth/teeth dental problems 0.0 0.0 0.0 0.0 0.2
Heart attack 3.9 5.0 8.2 2.9 -1.3
Allergy 0.3 0.7 0.7 0.8 -0.8
Pain all over the body in last month 0.1 0.2 0.2 0.4 0.4
Diabetes (self-reported) 1.0 1.5 2.1 0.9 1.4
Hayfever/allergic rhinitis (self-reported) 2.1 2.7 5.3 -0.3 2.3
Medication: Ramipril 0.0 0.0 0.0 -0.0 -0.2
Medication: Simvastatin 0.6 0.9 1.7 -0.3 1.3
Fluid intelligence score 1.7 3.5 6.6 0.6 -2.6
Illnesses of siblings 0.2 0.2 0.5 -0.7 0.0
Neuroticism score 0.4 0.8 1.4 0.4 -1.2
Weight 0.1 0.7 1.1 -0.5 -1.0
Impedance of arm (right) 0.2 1.1 1.6 -1.2 -0.8
Arm fat percentage (right) 0.4 1.5 3.0 -1.7 -0.0
Trunk fat-free mass 0.2 1.2 2.3 0.4 -1.5
Hip circumference 0.9 3.9 6.3 -1.2 -2.5
Time employed in main current job 2.0 2.3 3.4 1.8 1.1
Alcohol intake versus 10 years previously 1.1 1.6 2.0 1.4 1.1
Father’s age at death 0.3 0.4 0.5 -0.6 0.7
Worrier / anxious feelings 0.2 0.4 0.7 0.8 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.2 4.5 0.2 -2.1
Falls in the last year 0.4 0.5 0.9 -0.9 -0.4
Hair/balding pattern: Pattern 3 0.5 0.8 1.3 1.1 0.5
Number of live births 0.4 0.5 0.9 0.9 0.4
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 7.6 -0.1 -2.8
Pulse rate 0.9 1.6 2.7 0.6 1.7
Happiness 0.4 0.5 0.9 -0.9 -0.3
Noisy workplace 1.7 2.1 3.5 1.9 -0.8
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.1 -0.1 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.6 -0.8 -0.3
Mouth/teeth dental problems: Dentures 0.5 0.9 1.4 -0.5 1.2
Asthma 0.7 1.4 2.8 0.2 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.5 -0.6 -0.7
Medication: Cholesterol lowering 0.1 0.2 0.3 0.3 0.6
Depression (self-reported) 0.0 0.0 0.0 -0.1 0.2
Medication: Lansoprazole 0.8 0.9 1.6 1.3 -0.3
Prospective memory result 1.7 2.1 4.0 0.3 2.0
Lung cancer (father) 0.1 0.1 0.1 0.4 -0.3
Illnesses of mother 2.1 2.6 2.8 -1.7 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 1.8 -0.7 -1.3
Pulse wave Arterial Stiffness index 0.5 0.6 1.2 1.1 -0.1
Impedance of arm (left) 0.3 1.6 2.4 -1.6 -0.9
Arm fat mass (right) 0.3 1.1 1.6 -1.3 -0.7
Trunk predicted mass 0.2 1.2 2.4 0.3 -1.5
Standing height 0.5 4.7 9.4 -0.2 -3.1
Length of working week for main job 0.6 0.7 1.3 -0.3 1.1
Exposure to tobacco smoke at home 1.1 1.2 2.2 -0.5 1.5
Breastfed as a baby 1.6 2.0 2.7 -1.6 1.1
Tense / ‘highly strung’ 1.8 2.9 5.1 2.3 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.2 -1.1 -0.4
Hair/balding pattern: Pattern 4 0.3 0.7 1.2 0.4 -1.1
Birth weight of first child 0.1 0.2 0.4 0.7 0.1
Peak expiratory flow (PEF) 2.0 4.6 9.0 0.5 -3.0
Pulse wave reflection index 0.4 0.5 0.9 0.2 -0.9
Ever highly irritable/argumentative for 2 days 0.4 0.5 0.6 0.7 -0.7
Loud music exposure frequency 0.1 0.1 0.1 0.1 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 0.3 -0.7
Mouth/teeth dental problems: Bleeding gums 2.5 3.2 4.6 1.4 -2.1
Blood clot in the leg (DVT) 0.9 1.1 2.1 -0.4 1.4
Medication: Paracetamol 0.3 0.4 0.7 0.5 -0.8
Headache pain in last month 0.2 0.4 0.6 0.4 -0.8
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.9 -1.0 -0.2
Glaucoma (self-reported) 1.1 1.3 2.4 0.4 -1.6
Gout (self-reported) 0.7 0.9 1.7 -1.3 -0.3
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.3 1.5 -0.2
Medication: Amlodipine 4.2 5.9 10.4 3.2 1.2
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.5 -0.7 0.5
Birth weight 0.3 0.7 1.1 0.6 -1.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 0.6 -0.3
High blood pressure (siblings) 0.6 0.8 1.4 1.2 -0.4
Forced vital capacity (FVC), Best measure 0.3 1.2 1.3 -1.1 -1.1
Body fat percentage 0.4 1.6 3.1 -1.8 -0.4
Leg fat percentage (right) 0.2 0.7 1.4 -1.2 0.0
Arm fat-free mass (right) 0.2 1.3 2.6 -0.0 -1.6
Exposure to tobacco smoke outside home 0.8 1.0 1.8 1.3 -0.5
Comparative body size at age 10 1.2 3.3 5.2 -1.1 2.3
Number of full brothers 1.8 2.2 2.7 1.6 -1.3
Worry too long after embarrassment 0.3 0.5 0.7 -0.9 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 -0.2 -1.0
Wheeze or whistling in the chest in last year 0.3 0.6 1.1 1.1 -0.3
Number of children fathered 0.4 0.4 0.7 -0.8 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.0 0.8 -1.0
Age at first live birth 0.4 0.7 1.3 1.2 -0.2
Pulse wave peak to peak time 0.4 0.5 0.9 -1.0 -0.1
Health satisfaction 0.1 0.1 0.1 0.2 0.3
Shortness of breath walking on level ground 1.1 1.4 1.7 1.3 1.0
Qualifications: College or University degree 1.2 3.8 5.9 -2.4 -1.3
Eye problems/disorders: None of the above 1.1 1.3 2.1 -0.7 1.4
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.5 -0.1 -1.2
Emphysema/chronic bronchitis 0.0 0.0 0.0 0.2 0.1
Medication for pain relief, constipation, heartburn 0.9 1.5 1.6 -1.3 1.2
Neck or shoulder pain in last month 0.9 1.3 2.6 -0.1 -1.6
Medication: Blood pressure 0.3 0.5 1.1 1.0 -0.1
Angina (self-reported) 0.7 1.0 1.0 1.0 1.0
Migraine (self-reported) 0.7 0.8 1.6 -1.3 0.0
Medication: Ibuprofen 0.3 0.4 0.8 -0.9 0.1
Medication: Allopurinol 1.0 1.4 2.6 -1.6 -0.2
Medication: Omeprazole 0.4 0.5 0.8 0.9 0.4
Medication: Seretide 50 evohaler 0.5 0.6 0.6 -0.8 -0.8
Mean time to correctly identify matches 1.5 2.9 4.6 -1.1 2.1
Heart disease (mother) 2.4 3.0 4.0 2.0 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 0.1 -0.3
Whole body fat mass 0.3 1.3 2.0 -1.4 -0.7
Leg fat mass (right) 0.2 0.7 1.0 -1.0 -0.6
Arm predicted mass (right) 0.2 0.8 1.6 0.0 -1.3
Pulse rate, automated reading 0.2 0.7 1.3 0.1 1.1
Alcohol intake frequency. 0.8 1.9 2.6 1.1 1.6
Comparative height size at age 10 0.2 1.2 1.5 1.0 -1.2
Number of full sisters 0.1 0.1 0.2 0.3 -0.4
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.5 0.0
Overall health rating 0.9 1.9 2.6 -1.0 1.6
Chest pain or discomfort 0.9 1.4 1.5 1.1 -1.2
Had major operations 0.4 0.5 0.9 -0.9 -0.3
Age at last live birth 1.3 1.9 3.7 1.9 0.2
Family relationship satisfaction 1.1 1.3 1.4 -1.2 1.1
Leg pain on walking 1.4 1.8 2.6 1.0 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.7 0.6 -0.8
Commuting to job workplace: Car/motor vehicle 1.0 1.1 1.7 1.3 0.7
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.2 -0.5 -0.5
Medication: Aspirin 0.1 0.1 0.3 0.5 0.1
Supplements: Vitamin C 0.2 0.3 0.5 -0.1 0.7
Knee pain experienced in last month 2.8 4.4 8.4 0.6 -2.9
Hypertension (Self-reported) 0.7 2.0 4.0 -0.3 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.7 0.8 0.2
Illnesses of father: Heart disease 1.4 1.9 2.9 -1.0 1.7
Illnesses of siblings: Diabetes 0.2 0.2 0.3 0.4 -0.6
Smoking status: Previous 0.1 0.1 0.2 -0.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 9.1 0.3 -3.0
Whole body fat-free mass 0.2 1.3 2.5 0.2 -1.6
Leg fat-free mass (right) 0.2 1.1 2.3 -0.0 -1.5
Arm fat percentage (left) 0.4 1.6 3.2 -1.8 -0.2
Average weekly red wine intake 0.8 1.1 1.3 -1.1 -1.0
Handedness (chirality/laterality): Left-handed 0.0 0.1 0.1 -0.3 -0.2
Mood swings 0.4 0.7 0.9 0.6 -1.0
Loneliness, isolation 2.8 3.9 7.7 -0.3 -2.8
Long-standing illness, disability or infirmity 0.7 1.1 2.0 -0.3 1.4
Ever had bowel cancer screening 0.9 1.0 1.1 -1.0 1.0
Diabetes diagnosed by doctor 0.5 0.8 1.1 0.8 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.3 0.6 0.0
Friendships satisfaction 0.2 0.2 0.4 0.7 0.0
Qualifications: nursing, teaching 0.5 0.8 0.8 -0.9 -0.8
Commuting to job workplace: Walk 0.5 0.6 0.9 0.5 -1.0
Eye problems/disorders: Cataract 1.0 1.2 2.3 -0.3 -1.5
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 3.3 0.6 -1.8
Medication for cholesterol 0.4 0.6 0.6 0.7 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 -0.7 0.4
Back pain experienced in last month 0.4 0.6 1.0 -1.0 0.4
Mineral and other dietary supplements 1.0 1.3 2.5 -0.3 -1.6
Breast cancer (self-reported) 0.4 0.5 0.9 0.9 -0.3
Asthma (self-reported) 1.0 2.0 3.7 0.4 1.9
Osteoporosis (self-reported) 0.1 0.1 0.1 0.3 -0.3
Osteoarthritis (self-reported) 0.2 0.3 0.5 0.3 -0.7
Medication: Aspirin 0.2 0.2 0.3 0.5 0.5
Medication: Gliclazide 1.9 2.1 2.7 -1.2 1.6
Illnesses of father: None of the above (group 1) 0.7 0.9 1.2 0.8 -1.1
Smoking status: Current 0.4 0.6 0.6 0.8 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.2 -0.5 0.3
Whole body water mass 0.2 1.3 2.5 0.1 -1.6
Leg predicted mass (right) 0.2 1.2 2.5 -0.0 -1.6
Arm fat mass (left) 0.3 1.1 1.7 -1.3 -0.6
Number of self-reported non-cancer illnesses 0.4 0.6 1.1 -0.4 1.1
Average weekly champagne plus white wine intake 1.0 1.4 2.0 -0.9 1.4
Miserableness 0.4 0.7 1.4 0.2 -1.2
Guilty feelings 2.6 3.9 7.8 0.0 -2.8
Wears glasses or contact lenses 0.7 0.8 1.0 -1.0 0.8
Ever taken oral contraceptive pill 0.3 0.3 0.7 0.2 -0.8
Hearing aid user 1.5 1.7 3.0 1.7 0.7
Mother’s age at death 1.7 2.1 3.6 1.9 0.8
Financial situation satisfaction 1.1 1.4 2.7 1.7 -0.2
Tinnitus: Yes, now most or all of the time 3.6 4.2 7.0 2.7 -1.1
Commuting to job workplace: Public transport 2.4 2.8 3.1 -1.6 -1.7
Eye problems/disorders: Glaucoma 1.2 1.4 1.6 1.1 -1.2
Medication: Blood pressure 0.5 1.0 1.6 -0.6 1.3
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.1 -0.3 0.0
Supplements: Fish oil (including cod liver oil) 1.2 1.6 3.1 0.1 1.8
High cholesterol (Self-reported) 0.3 0.5 0.7 0.5 0.8
Medication: Bendroflumethiazide 0.3 0.4 0.8 0.1 0.9
Medication: Paracetamol 0.2 0.4 0.5 0.5 -0.7
Medication: Lisinopril 3.2 4.2 5.3 -2.3 1.7
Medication: Atorvastatin 0.8 0.9 1.3 1.1 0.8
Illnesses of father: High blood pressure 1.4 1.7 3.2 -0.5 1.8
Alcohol drinker status: Never 1.0 1.2 2.5 -0.1 1.6
Ever smoked 0.3 0.5 1.0 -1.0 0.3
Basal metabolic rate 0.2 1.3 2.7 0.0 -1.6
Leg fat percentage (left) 0.2 0.6 1.1 -1.1 0.1
Arm fat-free mass (left) 0.2 1.1 2.2 0.3 -1.5
Number of operations (self-reported) 0.2 0.2 0.3 -0.4 -0.6
Average weekly beer plus cider intake 0.7 0.9 1.5 1.2 -0.6
Irritability 1.1 1.9 3.6 1.9 0.3
Risk taking 1.5 2.2 4.0 2.0 -0.6
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.8 -1.7 -0.2
Fractured/broken bones in last 5 years 0.9 1.2 1.4 -1.2 -1.0
Age started oral contraceptive pill 0.7 0.9 1.8 0.1 1.4
Diastolic blood pressure, automated reading 1.8 5.5 9.9 -3.1 1.1
Ever depressed for a whole week 1.9 2.4 4.3 -2.1 0.7
Unable to work because of sickness or disability 0.0 0.0 0.1 0.0 0.3
Commuting to job workplace: Cycle 0.3 0.4 0.4 0.7 -0.5
Myopia 0.6 0.9 1.7 -1.3 -0.2
Vascular/heart problems diagnosed by doctor 1.0 2.6 5.1 0.4 -2.2
Cholesterol lowering medication 1.3 1.9 3.3 -0.6 1.8
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.9 0.5 1.0
Pain experienced in last month 0.3 0.5 1.0 0.0 1.0
Supplements: Calcium 1.4 1.6 1.7 -1.2 1.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.1 0.4 0.2
Heart attack/myocardial infarction (self-reported) 4.3 5.6 9.1 3.0 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.0 -0.6 1.0
Heart disease (siblings) 0.1 0.1 0.2 0.2 0.4
Alcohol drinker status: Previous 1.4 1.6 3.1 0.1 1.8
Pack years of smoking 0.0 0.0 0.0 0.1 -0.2
Impedance of whole body 0.2 0.8 1.0 -1.0 -0.8
Leg fat mass (left) 0.1 0.5 0.8 -0.9 -0.4
Arm predicted mass (left) 0.2 1.0 1.9 -0.2 -1.4