TWAS hub - PCDHB14

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0998	0.0456	8.0e-03	0.044	NA	0.012	NA	0.035	2.3e-04	NA	3.4e-02	NA	9.3e-04
2	GTEx	Nerve Tibial	0.1481	0.0481	2.1e-04	0.118	NA	0.108	NA	0.115	1.0e-08	NA	4.5e-08	NA	1.7e-08
3	GTEx	Pancreas	0.1750	0.0640	1.0e-03	0.135	NA	0.133	NA	0.123	2.7e-06	NA	3.1e-06	NA	7.1e-06
4	GTEx	Testis	0.4050	0.0780	1.2e-08	0.337	NA	0.342	NA	0.339	1.3e-15	NA	6.7e-16	NA	9.7e-16
5	ROSMAP	Brain Pre-frontal Cortex	0.0475	0.0237	1.7e-02	0.005	-0.001	0.005	0.013	0.016	6.1e-02	0.51	6.1e-02	0.0065	2.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Alcohol drinker status: Never	8.3	10.0	27.5	-0.7	3.9	2.0	5.2	-1.5
Unable to work because of sickness or disability	4.7	6.0	17.1	-1.8	4.1	2.7	1.6	-0.2
Length of working week for main job	3.4	3.8	8.5	2.4	-2.9	-1.3	-1.7	0.5
Emphysema/chronic bronchitis	3.4	3.8	8.4	-1.2	2.2	2.1	2.9	0.0
Pulse wave peak to peak time	3.1	3.7	9.9	1.8	-1.9	-3.1	0.9	0.6
Medication: Gliclazide	2.9	3.3	8.3	2.9	0.3	2.1	1.9	-0.5
Ever depressed for a whole week	2.8	3.4	10.6	-3.3	1.9	-1.2	-0.4	1.1
Pulse wave Arterial Stiffness index	2.5	2.9	7.6	-1.6	1.5	2.8	-1.2	-0.7
Bipolar Disorder (2011)	2.3	2.2	4.2	-0.7	2.0	1.5	2.0	0.4
Supplements: Zinc	2.2	2.4	6.0	1.7	-1.8	-2.5	-0.3	0.1
Average weekly spirits intake	2.1	2.5	6.7	1.6	-0.4	1.4	1.2	2.6
Commuting to job workplace: Cycle	2.1	2.5	6.5	0.2	-1.7	-1.7	-2.5	-0.5
Myopia	2.1	3.0	7.6	1.8	0.5	1.4	2.8	-1.4
Heart disease (siblings)	2.1	2.5	9.4	0.7	1.3	3.1	0.8	-0.7
Blood White Count	2.0	14.9	29.5	-3.6	5.4	4.5	2.2	2.7
Forced vital capacity (FVC)	2.0	7.8	12.9	3.5	-3.6	-3.2	-1.6	0.9
Supplements: Vitamin C	2.0	2.3	4.4	-0.1	-2.0	-1.5	-2.1	0.9
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	6.2	-2.5	0.5	-0.6	-1.2	2.0
Forced vital capacity (FVC), Best measure	1.9	7.1	12.4	3.2	-3.4	-3.5	-0.9	0.0
Alcohol intake frequency.	1.9	4.4	9.4	-1.4	3.1	2.8	1.6	0.6
Overall health rating	1.9	4.2	15.6	0.1	1.9	3.9	0.7	1.0
Long-standing illness, disability or infirmity	1.9	3.0	7.7	2.2	0.8	2.8	1.3	-0.3
Diabetes diagnosed by doctor	1.9	3.2	11.6	0.8	1.7	3.4	0.6	-0.5
Hearing aid user	1.9	2.2	4.7	0.9	0.7	0.9	2.0	-2.2
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.3	-0.9	2.2	2.3	0.5	0.3
Back pain experienced in last month	1.8	2.7	5.8	1.0	-2.4	0.3	-2.3	1.1
Alzheimer’s Disease (in father)	1.7	1.8	3.8	1.2	-1.9	-1.9	-0.6	0.3
Pack years adult smoking proportion	1.7	2.5	5.8	0.1	1.5	2.1	2.4	-0.2
Forced expiratory volume in 1-second (FEV1)	1.7	5.8	9.6	3.1	-2.9	-2.7	-1.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.6	10.4	2.9	-2.9	-3.2	-0.7	0.3
Age at last live birth	1.7	2.5	5.9	0.9	1.4	0.4	1.9	-2.4
Pack years of smoking	1.7	2.5	5.2	0.2	1.4	2.3	2.3	0.1
Frequency of depressed mood in last 2 weeks	1.6	2.2	5.2	-0.3	-1.8	-2.3	-1.5	0.4
Alcohol intake versus 10 years previously	1.6	2.4	4.1	-1.8	2.0	1.7	-1.0	0.8
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	4.6	0.9	-2.1	-1.6	-0.4	1.1
Pain experienced in last month	1.6	2.7	11.1	0.4	1.1	-0.5	3.3	-0.8
Bipolar Disorder or Schizophrenia	1.5	3.6	6.0	-1.7	2.4	1.9	2.3	0.6
Schizophrenia (2018)	1.5	3.2	5.0	-1.7	2.2	2.0	1.4	1.4
Waist circumference	1.5	5.4	11.6	2.3	-0.7	2.7	1.5	3.4
Medication: Lansoprazole	1.5	1.7	3.6	1.0	0.4	0.8	1.9	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.7	5.3	-1.5	0.6	-0.8	-0.6	2.3
Average weekly red wine intake	1.5	2.2	6.1	0.4	-2.5	-1.6	-1.5	0.1
Osteoporosis (self-reported)	1.5	1.9	3.3	-0.5	1.8	1.8	1.5	0.6
Guilty feelings	1.5	2.3	5.0	-0.6	-1.2	-0.3	-2.1	2.2
Leg fat percentage (left)	1.5	5.3	12.6	0.5	1.5	3.5	2.2	2.5
Type 2 Diabetes (T2D) (2012)	1.4	1.7	6.6	0.2	-1.0	-2.6	-0.8	0.1
Type 2 Diabetes (T2D) (2018)	1.4	2.6	8.9	1.5	1.2	3.0	0.6	-0.5
Neuroticism	1.4	3.4	7.8	1.0	-2.8	-1.3	-1.6	2.0
Body fat percentage	1.4	5.6	11.6	0.7	1.8	3.4	3.0	1.9
Depressed Affect (Nagel 2018)	1.3	2.7	4.8	-0.2	-2.2	-2.1	-1.7	1.3
Trunk fat percentage	1.3	5.0	10.2	0.9	1.5	3.1	3.2	1.6
Arm fat percentage (right)	1.3	5.3	10.1	1.0	1.5	3.2	2.7	2.3
Father’s age at death	1.3	1.7	4.8	0.8	-2.2	-1.2	-0.5	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.7	-0.5	-1.5	-1.1	-1.9	1.1
Birth weight of first child	1.3	2.3	5.5	2.3	-1.3	0.3	0.6	-1.9
Shortness of breath walking on level ground	1.3	1.5	3.7	0.8	1.6	1.9	0.1	0.6
Arm fat percentage (left)	1.3	5.2	10.0	0.9	1.6	3.2	2.8	2.1
Pain type(s) experienced in last month: Hip pain	1.3	1.7	6.3	-1.0	0.2	0.7	-2.5	0.8
Verbal and Numeric Reasoning (VNR)	1.2	2.8	6.3	2.2	-2.5	-1.2	-0.4	-1.2
Waist Hip Ratio (WHR)	1.2	5.3	11.0	2.1	-3.3	-0.5	-2.6	2.0
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.8	1.7	0.4	1.3	1.3	0.4
Fed-up feelings	1.2	2.2	4.7	-0.7	-2.2	-1.9	-1.3	0.7
Medication: Atenolol	1.2	1.4	2.9	-1.7	1.4	0.1	1.4	0.8
Body mass index (BMI)	1.2	5.0	9.9	0.3	1.5	3.1	2.2	2.8
Diabetes (self-reported)	1.2	1.8	6.8	1.0	0.7	2.6	-0.5	-0.5
Medication: Simvastatin	1.2	1.8	3.2	-1.4	1.8	1.6	0.4	-1.1
Falls in the last year	1.2	1.6	4.2	-1.1	2.1	1.4	0.6	-0.5
Leg fat percentage (right)	1.2	4.5	9.4	0.4	1.5	3.1	1.9	2.6
Neck or shoulder pain in last month	1.2	1.7	2.8	1.3	-1.7	-1.3	-1.3	0.8
Medication: Blood pressure	1.2	2.0	4.5	-0.6	1.4	2.1	1.6	-0.9
Medication: Ibuprofen	1.2	1.4	3.2	-0.4	-1.5	-0.6	-1.8	0.9
Medication: Allopurinol	1.2	1.6	4.6	0.1	-1.4	-2.2	-1.2	0.3
Had major operations	1.2	1.4	3.8	0.9	-1.5	-1.9	-0.2	0.2
Arm fat mass (left)	1.2	4.8	8.0	1.7	0.4	2.8	2.6	2.5
Average weekly champagne plus white wine intake	1.2	1.7	4.2	-2.0	0.5	-1.8	0.0	0.9
Leg fat mass (left)	1.2	4.8	10.0	1.4	0.4	3.2	2.1	2.7
Neuroticism (Nagel 2018)	1.1	2.6	7.1	1.0	-2.7	-0.9	-1.2	1.7
Major Depression (MDD)	1.1	1.4	3.5	-1.9	1.3	-0.5	0.5	-1.1
Mean Putamen Volume	1.1	1.3	2.6	0.7	1.6	0.9	1.5	-0.6
HDL Cholesterol	1.1	1.9	4.2	1.7	-1.3	-0.8	0.3	-2.0
Sensitivity / hurt feelings	1.1	1.9	4.4	1.4	-2.1	0.4	-1.1	1.4
Ever used hormone-replacement therapy (HRT)	1.1	1.5	5.8	-0.9	-0.5	-2.4	-0.5	0.4
Serious illness, injury or assault to yourself	1.1	1.4	3.8	-1.7	1.9	-0.3	-0.1	-0.3
Trunk fat mass	1.1	4.6	8.9	1.6	0.7	2.8	3.0	1.8
Alcohol usually taken with meals	1.1	1.8	7.1	-0.4	0.2	-1.1	-0.5	2.7
Had other major operations	1.1	1.3	2.9	1.7	-1.2	-1.4	0.4	0.2
Heart attack	1.1	1.5	3.4	-1.9	1.4	1.1	-0.8	0.4
Neuroticism score	1.1	2.3	5.5	0.5	-2.3	-1.3	-1.3	1.6
Number of live births	1.1	1.5	4.0	-0.7	1.3	2.0	0.7	-1.0
Arm fat mass (right)	1.1	4.7	7.3	1.8	0.4	2.7	2.4	2.6
Standing height	1.1	10.7	25.9	5.1	-4.8	-1.9	0.1	-0.6
Medication for pain relief, constipation, heartburn	1.1	1.9	4.8	2.2	0.0	0.1	1.9	-1.0
Mean time to correctly identify matches	1.1	2.1	5.8	0.5	1.5	2.4	1.6	-0.3
Heart disease (mother)	1.1	1.3	4.6	-0.9	0.6	-0.9	0.1	2.1
Whole body fat mass	1.1	4.7	9.4	1.5	0.7	3.1	2.7	2.0
Leg fat mass (right)	1.1	4.2	8.1	1.3	0.3	2.7	1.9	2.8
Number of full sisters	1.1	1.3	2.9	1.7	-0.9	1.6	0.2	0.5
Medication: Paracetamol	1.1	1.7	4.3	-2.1	0.0	-0.2	-1.2	1.6
Supplements: Calcium	1.1	1.2	2.6	-1.6	1.5	0.7	-0.4	0.6
Rheumatoid Arthritis	1.0	1.3	1.7	1.0	1.2	1.3	1.1	-1.2
Triglycerides	1.0	1.6	4.4	-2.1	1.4	1.2	-0.3	0.1
Height	1.0	19.8	55.5	7.5	-6.2	-2.1	0.4	-1.1
Medication: Metformin	1.0	1.4	4.0	0.7	1.3	2.0	0.7	0.2
Stomach or abdominal pain in last month	1.0	1.2	3.0	-1.7	1.5	0.6	-0.6	-0.2
Supplements: Glucosamine	1.0	1.3	2.7	-0.1	-1.6	-1.0	-1.6	0.1
Sitting height	1.0	6.9	14.9	3.5	-3.9	-2.1	-0.5	-1.7
Hearing difficulty/problems with background noise	1.0	1.6	2.7	-1.3	-0.8	-1.2	-1.2	1.7
Medication: Cholesterol lowering	1.0	1.5	3.3	-0.7	1.3	1.8	0.9	-1.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.4	0.7	-1.1	-2.1	-1.0	0.9
Medication: Ventolin 100micrograms inhaler	1.0	1.2	1.8	-1.4	1.3	1.3	-0.8	-0.7
High blood pressure (siblings)	1.0	1.5	2.8	0.3	1.3	1.6	-0.5	1.7
Worry too long after embarrassment	1.0	1.7	2.7	1.2	-1.0	1.6	-0.9	1.6
Wheeze or whistling in the chest in last year	1.0	1.8	4.6	-2.1	0.6	0.5	-0.9	1.7
Eye problems/disorders: None of the above	1.0	1.1	4.1	-2.0	1.0	0.4	-0.2	-0.7
Medication: Omeprazole	1.0	1.1	2.6	0.0	1.6	1.6	0.7	-0.3
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.9	-1.7	1.2	0.8	-0.9	0.5
Systolic Blood Pressure	0.9	4.3	9.1	-2.2	3.0	2.5	0.1	1.1
Average weekly fortified wine intake	0.9	1.0	3.9	-0.2	-1.0	-2.0	-0.3	-0.3
High blood pressure (mother)	0.9	1.2	3.2	-0.7	1.5	-0.0	1.8	0.1
Mouth/teeth dental problems	0.9	1.3	2.4	1.6	-0.1	0.6	1.5	-1.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.3	-0.3	-0.6	-2.1	-0.5	1.0
Weight	0.9	4.2	6.2	2.5	-0.8	2.1	2.0	2.4
Depression (self-reported)	0.9	1.0	3.3	0.7	1.0	1.8	0.6	0.1
Prospective memory result	0.9	1.2	2.2	1.2	-1.1	0.6	-1.5	-0.6
Illnesses of mother	0.9	1.2	3.0	1.7	-1.4	-0.5	0.1	-0.6
Medication: Paracetamol	0.9	1.6	4.5	-2.1	0.2	-0.7	-1.1	1.3
Comparative height size at age 10	0.9	5.1	13.8	3.4	-3.7	-0.1	-0.4	-0.2
Knee pain experienced in last month	0.9	1.4	3.7	-1.0	0.2	-0.0	-1.9	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.6	-0.1	1.1	1.0	1.2	-1.1
Qualifications: nursing, teaching	0.9	1.3	2.6	1.6	-1.1	-1.0	0.7	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.0	2.0	-0.5	-1.5	0.7	1.6
Bipolar Disorder (2018)	0.8	1.3	4.2	-0.5	1.1	0.5	2.0	-0.9
Intelligence (Savage-Jansen 2018)	0.8	2.5	5.3	2.3	-1.0	-1.7	0.8	-1.6
Age at First Birth	0.8	1.2	3.9	0.1	0.3	-2.0	-0.6	-1.3
Ever had hysterectomy (womb removed)	0.8	0.9	2.7	-0.8	0.8	0.3	1.7	-0.6
Systolic blood pressure, automated reading	0.8	2.4	4.5	-1.3	2.1	1.8	1.1	1.0
Angina	0.8	1.0	1.8	-0.4	1.3	1.3	-0.6	1.0
Townsend deprivation index at recruitment	0.8	1.1	2.7	-0.7	1.6	1.6	0.3	0.2
Maternal smoking around birth	0.8	1.1	4.4	1.0	0.4	2.1	-0.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.7	-0.3	0.4	-1.7	0.3	-1.2
Financial difficulties in last 2 years	0.8	1.1	3.1	0.1	-0.6	0.3	-1.4	1.8
Trunk fat-free mass	0.8	4.7	12.7	3.6	-2.7	0.3	0.6	1.8
Hip circumference	0.8	3.6	5.2	2.2	-0.0	2.1	2.3	1.9
Time employed in main current job	0.8	0.9	3.2	0.7	-1.8	-0.6	-0.6	0.1
Trunk predicted mass	0.8	4.8	13.2	3.6	-2.7	0.3	0.7	1.8
Exposure to tobacco smoke at home	0.8	0.9	2.1	-1.2	1.5	0.6	0.6	0.2
Pulse wave reflection index	0.8	1.0	2.9	-1.3	0.3	1.7	-0.6	-0.4
Blood clot in the leg (DVT)	0.8	1.1	3.6	1.9	-0.2	-0.1	0.7	-1.1
Ever had bowel cancer screening	0.8	1.0	3.0	-0.3	-1.1	0.2	-1.7	0.8
Miserableness	0.8	1.4	3.3	0.4	-1.7	-0.2	-1.8	0.9
High cholesterol (Self-reported)	0.8	1.3	3.5	-1.5	1.9	0.1	0.4	0.7
Medication: Lisinopril	0.8	1.1	3.6	0.3	0.5	1.9	0.8	-0.8
Basal metabolic rate	0.8	4.4	9.9	3.1	-2.1	1.1	1.3	2.2
Alcohol drinker status: Previous	0.8	1.0	2.2	-0.7	1.5	0.9	1.1	0.3
Schizophrenia (2014)	0.7	1.5	2.3	-0.9	1.4	1.2	1.5	1.0
Hearing difficulty/problems: Yes	0.7	1.1	2.3	0.6	-1.3	-0.0	-1.5	1.1
Severe depression (siblings)	0.7	0.8	1.7	-1.3	1.3	-0.2	0.5	-0.5
Leg fat-free mass (left)	0.7	3.4	7.3	2.7	-2.0	0.8	1.2	1.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.5	-1.2	0.2	-0.9	-0.9	0.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.5	-0.2	-1.0	-2.1	-1.4	0.2
Leg predicted mass (left)	0.7	3.5	7.8	2.8	-2.0	0.8	1.3	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.0	-1.7	0.5	-1.1	-1.2	1.3
Medication: Ramipril	0.7	0.8	1.7	-0.9	-0.1	1.0	-1.3	0.9
Illnesses of siblings	0.7	1.0	2.4	-0.8	-0.7	-1.5	1.0	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.3	1.8	-0.3	1.1	0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.2	0.9	-1.3	-2.0	-0.8	-0.7
Lung cancer (father)	0.7	0.8	2.8	-1.7	0.9	0.2	-0.5	0.2
Arm fat-free mass (right)	0.7	3.4	6.6	2.6	-1.8	1.2	1.0	2.3
Exposure to tobacco smoke outside home	0.7	1.0	2.0	-0.5	0.7	1.3	-0.7	1.4
Age at first live birth	0.7	1.2	3.2	1.1	0.2	-0.8	1.1	-1.8
Migraine (self-reported)	0.7	0.9	2.2	-0.8	1.2	-0.1	1.5	-0.6
Arm predicted mass (right)	0.7	3.4	7.1	2.7	-1.6	1.2	1.0	2.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.5	1.2	-0.0	1.1	1.2	0.3
Whole body fat-free mass	0.7	4.1	9.8	3.1	-2.3	0.7	1.0	2.0
Friendships satisfaction	0.7	0.9	2.3	-0.6	-0.0	-1.5	-1.2	-0.6
Whole body water mass	0.7	4.2	10.0	3.2	-2.3	0.7	1.1	2.1
Leg predicted mass (right)	0.7	3.6	7.3	2.7	-1.9	1.1	1.6	1.8
Wears glasses or contact lenses	0.7	0.8	3.1	0.8	-0.4	-1.8	0.3	0.4
Medication: Bendroflumethiazide	0.7	1.1	3.5	-1.9	1.1	0.9	0.0	0.3
Arm fat-free mass (left)	0.7	3.8	8.7	3.0	-1.7	1.1	1.3	2.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.4	1.8	-0.4	-0.1	0.4	-1.0
Arm predicted mass (left)	0.7	3.7	7.5	2.7	-1.8	1.0	1.1	2.3
Crohns Disease (2012)	0.6	0.9	1.6	-1.3	0.6	-0.8	-1.3	0.7
HbA1C	0.6	0.6	2.6	0.4	-1.6	0.1	0.3	0.6
Blood Red Count	0.6	5.8	15.1	-3.9	3.5	1.4	0.2	-0.1
Heel T-Score	0.6	4.7	9.4	-2.2	0.5	-2.8	-1.0	3.1
BMI	0.6	3.6	7.6	-0.4	1.0	2.7	1.5	2.8
Lung FEV1/FVC ratio	0.6	3.0	5.4	2.0	-1.7	-1.4	0.5	2.3
Chronotype (morning person)	0.6	1.4	5.0	-0.1	-1.0	-2.2	-0.5	-0.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.0	1.4	0.3	0.6	-0.1	-1.1
Relative age voice broke	0.6	0.8	2.6	-1.6	0.5	-1.1	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.1	-1.4	0.1	-1.4	-0.9	1.5
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.9	-1.3	-1.2	-0.1	-0.2
Pain all over the body in last month	0.6	0.6	1.5	-0.4	1.2	0.3	0.6	1.0
Fluid intelligence score	0.6	1.3	2.5	0.7	-0.5	-1.4	1.1	-1.6
Hair/balding pattern: Pattern 3	0.6	0.9	2.9	-1.1	-0.2	-0.4	-1.7	-0.1
Happiness	0.6	0.7	1.6	-0.9	0.7	-1.3	-0.1	-0.8
Breastfed as a baby	0.6	0.7	2.5	0.4	0.9	1.6	0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.1	-1.4	-0.0	-1.2	-0.7	0.7
Peak expiratory flow (PEF)	0.6	1.4	3.9	0.3	-0.7	-1.0	-1.2	2.0
Gout (self-reported)	0.6	0.9	1.8	0.8	-1.3	-1.2	-0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.5	0.0	0.2	1.0	-0.8	-1.2
Angina (self-reported)	0.6	0.8	1.1	-0.4	1.0	1.0	-0.9	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.6	-0.2	1.0	-0.9	1.3	0.4
Illnesses of siblings: Diabetes	0.6	0.7	2.4	-0.8	-0.2	-0.3	-1.6	0.6
Leg fat-free mass (right)	0.6	3.4	6.8	2.6	-1.9	1.0	1.5	1.8
Mineral and other dietary supplements	0.6	0.8	2.0	-1.4	0.9	-0.6	0.5	1.0
Breast cancer (self-reported)	0.6	0.7	1.6	-0.6	0.8	1.3	-0.4	0.8
Financial situation satisfaction	0.6	0.7	2.9	-0.1	-0.4	0.2	-1.7	0.7
Medication: Atorvastatin	0.6	0.7	1.1	-0.8	1.0	0.0	-0.9	1.1
Ever smoked	0.6	1.1	2.0	1.1	-1.4	0.9	-0.7	1.1
Average weekly beer plus cider intake	0.6	0.9	4.3	0.0	-0.3	2.1	-0.1	-0.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.0	0.3	-0.8	-1.4	-0.4	0.6
Cholesterol lowering medication	0.6	0.9	1.9	-0.5	1.4	1.4	-0.5	0.4
Prostate Cancer	0.5	0.7	2.0	0.4	0.5	0.4	1.4	-0.8
Fasting Glucose	0.5	0.6	1.3	0.3	-0.8	0.6	-1.2	0.9
LDL Cholesterol	0.5	0.8	1.8	1.0	-0.1	1.4	0.4	1.0
Relative age of first facial hair	0.5	1.0	1.8	0.1	-0.2	-1.3	1.3	1.3
Age when periods started (menarche)	0.5	1.3	4.4	-1.1	0.5	0.3	0.6	-2.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.9	0.3	0.5	0.6	1.4	0.1
Multivitamins +/- minerals	0.5	0.6	1.9	0.7	0.5	0.4	-0.4	1.4
Medication: Levothyroxine sodium	0.5	0.9	2.1	0.1	0.9	1.4	0.8	-1.0
Past tobacco smoking	0.5	0.9	1.8	-0.0	1.0	-1.2	0.7	-1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.7	-0.2	-0.3	-1.0	-1.3	0.4
Qualifications: College or University degree	0.5	1.4	5.2	2.3	-0.5	-1.0	0.8	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.0	-0.5	0.1	1.4	0.6	0.2
Pulse rate, automated reading	0.5	1.7	4.0	2.0	0.5	0.9	1.8	-0.3
Suffer from ‘nerves’	0.5	0.8	1.6	-0.4	-1.0	-1.3	-0.4	-1.1
Chest pain or discomfort	0.5	0.8	1.5	-1.2	0.9	-0.7	-1.0	0.3
Family relationship satisfaction	0.5	0.6	2.1	-0.7	0.3	-0.5	-1.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	-1.2	0.5	0.9	-0.3	-0.5
Medication: Aspirin	0.5	0.6	1.2	-1.1	0.9	0.7	-0.8	0.5
Smoking status: Previous	0.5	0.8	1.9	0.2	-1.4	1.0	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.7	1.9	-1.0	0.2	0.3	0.2
Mood swings	0.5	0.9	2.0	-1.1	-0.5	-1.4	-0.5	0.9
Commuting to job workplace: Walk	0.5	0.6	1.5	0.6	-0.2	0.9	0.5	-1.2
Mother’s age at death	0.5	0.6	1.1	-1.0	-1.0	-0.3	-1.0	-0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	1.1	0.6	0.8	0.8	-0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.2	0.6	-1.1	-0.6	-1.0	-0.5
Number of operations (self-reported)	0.5	0.8	2.5	0.8	-0.2	-1.6	0.9	0.5
Basal cell carcinoma (self-reported)	0.5	0.7	1.2	-0.8	0.4	-0.6	0.9	-1.1
Worry (Nagel 2018)	0.4	0.8	2.9	0.5	-1.7	-0.8	0.0	0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	1.3	-0.1	-1.1	-0.9	-0.8	0.3
Irritable Bowel Disease (IBD)	0.4	0.9	2.3	-0.6	-0.1	-0.6	-1.1	1.5
Ulcerative Colitis (UC)	0.4	0.8	1.4	0.2	-1.2	-0.8	-1.2	0.6
Reaction Time	0.4	0.8	1.7	-0.1	1.0	1.2	1.3	-0.1
Coronary Artery Disease (CAD)	0.4	0.4	1.7	1.3	0.4	0.5	-0.3	-0.3
Primary Biliary Cirrhosis	0.4	0.6	1.1	0.5	-0.1	-0.8	-1.0	1.0
Ulcerative Colitis	0.4	0.5	0.9	0.5	-0.7	0.4	-0.9	0.9
Blood Eosinophil Count	0.4	3.0	5.7	-1.6	2.4	2.1	1.0	1.1
Smoking Status	0.4	0.9	2.0	-0.4	-1.1	0.7	-0.8	1.4
Allergy or Eczema	0.4	0.9	1.9	0.5	-1.1	-1.1	-1.4	-0.2
Cardiovascular Disease	0.4	1.4	3.3	-1.8	0.4	0.7	-1.5	0.8
Number of treatments/medications taken	0.4	0.6	1.6	-1.3	0.9	0.9	-0.3	0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.4	-0.0	0.6	-0.7	0.1	1.2
Nervous feelings	0.4	0.7	1.8	0.8	-1.4	-0.1	0.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	-0.3	-0.7	-1.2	-0.4	0.8
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.6	0.8	0.6	0.9	-0.4
Had menopause	0.4	0.5	1.2	-0.2	-0.7	-1.1	-0.9	0.1
Impedance of arm (right)	0.4	1.8	5.8	0.4	0.0	-1.6	0.5	-2.4
Worrier / anxious feelings	0.4	0.8	3.0	0.3	-1.7	-0.7	-0.7	-0.3
Impedance of arm (left)	0.4	1.7	5.5	0.6	-0.3	-1.4	0.6	-2.4
Loud music exposure frequency	0.4	0.4	1.0	0.1	1.0	0.6	-0.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.2	1.1	-0.7	-0.6	0.7	-1.0
Headache pain in last month	0.4	0.6	1.0	-0.6	0.9	0.8	-1.0	0.6
Medication: Amlodipine	0.4	0.6	0.9	-1.0	-0.9	0.2	0.7	0.9
Birth weight	0.4	0.9	2.4	1.2	-1.6	-0.7	0.1	0.4
Number of full brothers	0.4	0.5	1.1	0.5	-0.3	0.8	0.5	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	-0.6	0.4	-0.3	-0.6	1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	0.9	0.3	0.9	0.5	0.4
Loneliness, isolation	0.4	0.5	2.1	-0.0	0.0	0.3	0.6	1.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	-0.9	0.1	0.0	-1.2	1.0
Osteoarthritis (self-reported)	0.4	0.5	0.8	0.9	0.3	0.7	0.8	-0.8
Medication: Aspirin	0.4	0.5	1.0	-0.8	1.0	0.5	-0.6	0.3
Ever taken oral contraceptive pill	0.4	0.5	1.6	-1.3	0.4	0.6	-0.5	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	0.8	-1.0	-0.4	-0.2	-0.5
Age started oral contraceptive pill	0.4	0.4	1.3	1.1	-0.2	0.1	0.8	0.4
Diastolic blood pressure, automated reading	0.4	1.1	2.7	0.7	0.3	1.0	1.6	1.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.1	0.5	0.6	-0.0	1.1
Crohns Disease (2017)	0.3	0.7	1.7	-0.7	1.0	-0.3	-0.3	1.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	-0.5	1.1	0.2	0.4	0.4
Lupus	0.3	0.4	0.6	-0.8	0.8	-0.7	0.1	-0.5
Lung FVC	0.3	1.5	3.3	1.8	-0.7	-1.8	-0.6	0.1
Medication: Co-codamol	0.3	0.3	1.1	0.2	0.1	0.5	0.3	1.1
Diabetes (father)	0.3	0.4	1.4	-0.4	0.6	1.2	0.3	-0.2
High blood pressure	0.3	0.9	3.0	0.2	-0.1	1.7	0.9	0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	-0.5	0.8	0.6	-0.6	-0.1
Number of incorrect matches in round	0.3	0.6	1.1	-1.1	-0.7	-1.1	-0.3	0.1
Hair/balding pattern: Pattern 4	0.3	0.6	2.6	0.0	0.2	0.4	0.6	1.6
Comparative body size at age 10	0.3	0.8	2.1	-0.1	-1.1	-0.7	-1.5	0.3
Health satisfaction	0.3	0.3	0.9	-0.3	0.7	0.4	-0.3	-0.9
Leg pain on walking	0.3	0.3	1.1	0.1	-0.0	0.0	-1.1	-0.7
Hypertension (Self-reported)	0.3	0.8	2.6	0.1	-0.3	1.6	0.5	0.9
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.4	-0.3	-0.6	-0.1	1.0
Illnesses of father: None of the above (group 1)	0.3	0.4	1.6	0.3	-0.3	-0.1	1.2	0.1
Number of self-reported non-cancer illnesses	0.3	0.6	1.2	0.0	0.4	1.1	0.8	1.0
Irritability	0.3	0.5	0.9	-0.5	-0.7	-0.4	-0.9	0.7
Depression (Nagel 2018)	0.2	0.3	0.9	-0.3	-0.9	-0.8	-0.3	-0.0
Neuroticism (2016)	0.2	0.3	1.2	0.3	-0.1	0.5	-0.2	1.1
Hypothyroidism (self reported)	0.2	0.5	1.7	-0.5	0.9	1.3	0.1	-0.1
Vitamin and mineral supplements	0.2	0.3	0.8	-0.1	0.1	0.3	0.9	-0.9
Diabetes (mother)	0.2	0.3	0.9	-0.0	0.4	1.0	0.0	0.6
Qualifications: None of the above	0.2	0.4	1.3	-0.4	-0.4	1.1	-0.5	-0.1
Allergy	0.2	0.4	0.9	-0.0	1.0	0.7	0.8	-0.1
Pulse rate	0.2	0.4	0.8	-0.3	0.9	-0.8	0.3	0.6
Noisy workplace	0.2	0.3	1.0	0.3	1.0	-0.1	-0.3	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.9	1.0	-0.4	-0.2	-0.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.9	0.6	0.5	0.0	-0.3
Illnesses of father: Heart disease	0.2	0.3	0.8	0.2	0.6	0.2	-0.9	0.0
Medication for cholesterol	0.2	0.3	0.9	0.9	-0.8	-0.3	-0.4	0.3
Asthma (self-reported)	0.2	0.4	1.2	0.5	-0.8	0.2	-1.1	-0.4
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.0	-0.5	0.2	0.4	0.8
Risk taking	0.2	0.3	0.8	-0.9	-0.0	-0.3	-0.7	0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.8	0.4	-0.3	-0.4	-0.0
Vascular/heart problems diagnosed by doctor	0.2	0.5	2.2	0.2	-0.0	-1.5	-0.3	-0.6
Impedance of whole body	0.2	1.1	4.5	0.2	0.1	-1.1	0.1	-2.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.0	-0.4	0.1	-0.4	-0.0
Blood Platelet Count	0.1	1.3	4.1	-0.8	2.0	1.1	0.6	-0.6
Hair Pigment	0.1	4.0	7.2	-2.2	2.7	2.1	0.1	-1.8
Tanning	0.1	1.7	3.1	1.3	-1.8	-1.8	0.1	-0.8
Hand grip strength (left)	0.1	0.4	1.1	0.4	-0.4	-0.6	-1.0	-0.4
Impedance of leg (right)	0.1	0.4	1.1	-0.0	0.3	-0.5	-0.8	-1.1
Hand grip strength (right)	0.1	0.1	0.4	-0.3	0.4	0.0	-0.7	0.2
Current tobacco smoking	0.1	0.2	0.5	-0.3	0.4	0.7	0.3	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.5	0.2	-0.7	0.1	-0.2	0.1
Taking other prescription medications	0.1	0.2	0.5	0.7	0.0	0.7	0.2	0.1
Impedance of leg (left)	0.1	0.4	1.2	-0.0	0.7	0.1	-0.2	-1.1
Asthma	0.1	0.3	1.0	0.1	-0.4	0.4	-1.0	-0.2
Tense / ‘highly strung’	0.1	0.2	0.5	-0.2	0.2	0.7	0.5	0.7
Glaucoma (self-reported)	0.1	0.1	0.5	0.7	0.1	0.2	0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	0.2	0.6	0.7	0.4	-0.5
Number of children fathered	0.1	0.1	0.2	0.4	-0.5	-0.3	-0.1	0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.4	-0.3	0.4	-0.2	-0.6	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.4	-0.5	0.3	-0.1	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	0.4	0.3	-0.4	-0.4	0.4
Smoking status: Current	0.1	0.1	0.1	-0.3	0.3	0.3	-0.1	-0.3
Commuting to job workplace: Public transport	0.1	0.2	0.8	-0.0	-0.0	-0.9	0.1	0.1
Medication: Blood pressure	0.1	0.2	0.6	-0.8	0.3	-0.0	-0.1	0.4
Breast Cancer	0.0	0.1	0.2	0.3	-0.3	0.3	0.4	-0.3
Ovarian Cancer	0.0	0.0	0.1	-0.3	-0.1	-0.3	0.2	0.0
Respiratory disease	0.0	0.1	0.3	-0.4	0.0	-0.0	-0.5	-0.2
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.1	-0.4	0.2	-0.2	-0.0

Hub : Genes

PCDHB14

Models

Trait associations