Hub : Genes

PCDHB15

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0830	0.0280	9.2e-05	0.046	0.061	0.050	0.061	0.049	2.6e-06	5.9e-08	9.5e-07	5.9e-08	1.2e-06
2	GTEx	Adipose Subcutaneous	0.2150	0.0590	6.0e-07	0.212	NA	0.255	NA	0.275	3.6e-17	NA	7.3e-21	NA	1.3e-22
3	GTEx	Artery Aorta	0.1610	0.0510	1.4e-04	0.030	NA	0.120	NA	0.099	9.1e-03	NA	4.1e-07	NA	4.2e-06
4	GTEx	Artery Tibial	0.1841	0.0565	4.2e-05	0.146	NA	0.115	NA	0.171	1.5e-11	NA	2.9e-09	NA	2.4e-13
5	GTEx	Nerve Tibial	0.1231	0.0514	6.9e-03	0.120	NA	0.103	NA	0.102	8.5e-09	NA	1.0e-07	NA	1.1e-07
6	GTEx	Pancreas	0.2400	0.1000	9.1e-03	0.028	NA	0.096	NA	0.079	2.3e-02	NA	7.4e-05	NA	3.0e-04
7	GTEx	Skin Sun Exposed Lower leg	0.1340	0.0520	2.1e-03	0.006	NA	0.024	NA	0.010	9.8e-02	NA	4.3e-03	NA	4.4e-02
8	GTEx	Testis	0.3100	0.0730	3.2e-05	0.147	NA	0.116	NA	0.114	4.8e-07	NA	7.8e-06	NA	1.0e-05
9	METSIM	Adipose	0.1001	0.0368	4.5e-06	0.079	0.032	0.067	0.061	0.068	6.0e-12	1.1e-05	2.5e-10	1.6e-09	1.9e-10
10	ROSMAP	Brain Pre-frontal Cortex	0.0411	0.0196	7.2e-03	-0.001	0.005	-0.002	0.004	-0.001	5.3e-01	6.5e-02	6.3e-01	7.8e-02	4.9e-01
11	TCGA	Breast Invasive Carcinoma	0.0357	0.0215	5.3e-03	0.007	0.002	-0.001	NA	0.003	1.2e-02	1.4e-01	5.4e-01	NA	7.3e-02
12	TCGA	Prostate Adenocarcinoma	0.0869	0.0504	1.5e-03	0.031	0.016	0.009	NA	0.014	3.2e-04	7.3e-03	3.5e-02	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.7	1.1	6.5	2.5	0.5	-0.1	0.5	1.1	0.5	0.5	-0.9	0.7	1.6	-0.1	-0.2
Bipolar Disorder or Schizophrenia	1.0	2.4	10.1	3.2	-1.4	-2.2	-1.4	-0.2	-1.5	-0.9	0.2	-1.0	1.5	-1.5	-1.1
Depressed Affect (Nagel 2018)	1.1	2.3	4.7	-1.9	1.7	2.0	1.6	1.4	2.0	2.2	0.3	1.1	0.4	0.6	1.2
Depression (Nagel 2018)	1.0	1.5	2.8	-1.4	1.3	1.1	1.3	1.5	1.7	1.1	-0.4	1.3	0.8	1.1	1.2
Intelligence (Savage-Jansen 2018)	1.0	2.9	10.6	-0.9	1.5	2.4	1.5	0.3	2.6	0.9	-3.3	1.2	0.3	1.6	1.3
Neuroticism (Nagel 2018)	0.3	0.8	4.6	-2.1	0.4	1.0	0.4	0.9	0.6	1.0	0.5	0.3	0.5	-0.3	0.7
Schizophrenia (2018)	1.6	3.4	7.6	2.0	-2.2	-2.7	-2.2	-1.2	-2.4	-1.5	1.0	-1.8	0.6	-1.9	-1.3
Schizophrenia vs Biploar Disorder	1.0	1.3	2.3	-0.2	-1.5	-0.9	-1.5	-1.3	-0.6	-1.3	0.7	-1.3	-1.2	-1.4	-0.8
Worry (Nagel 2018)	0.2	0.5	1.4	0.3	0.6	1.0	0.5	1.1	-0.6	0.3	-0.5	0.3	1.2	0.1	0.7
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	-0.1	-0.4	-0.5	-0.5	-0.3	-0.9	1.0	1.1	-0.6	-0.5	-0.6	-0.7
Alzheimer’s Disease (in father)	0.6	0.6	3.7	-0.3	1.2	1.9	1.1	0.3	0.2	0.5	0.0	0.4	-0.4	-0.1	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.6	0.6	0.6	0.5	0.5	0.1	-0.6	1.3	1.2	0.0	0.1	-0.2	-0.3
Crohns Disease (2017)	1.1	2.4	5.0	-1.8	-1.4	-0.5	-1.5	-2.2	0.6	-0.3	0.1	-1.6	-2.1	-1.6	-2.2
Irritable Bowel Disease (IBD)	0.6	1.4	4.2	-1.6	-1.2	-0.0	-1.2	-2.0	0.3	-0.4	0.3	-1.5	-0.5	-1.2	-1.6
Ulcerative Colitis (UC)	0.3	0.5	1.7	-1.0	-0.4	0.7	-0.4	-1.3	0.5	-0.6	0.3	-0.8	0.6	-0.5	-0.8
Major Depression (MDD)	3.2	3.9	10.3	2.1	1.6	1.6	1.6	2.4	3.2	1.8	-0.1	1.8	1.9	1.5	2.5
Reaction Time	0.1	0.2	0.8	-0.2	0.0	-0.4	0.1	0.8	0.0	-0.3	-0.6	0.8	0.1	0.9	0.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	9.3	-3.0	1.1	1.7	1.1	0.1	1.6	1.3	-0.5	0.9	-1.6	1.3	0.8
Breast Cancer	0.1	0.2	1.2	-1.1	0.1	-0.7	0.2	-0.0	0.7	0.3	-0.1	0.3	-0.4	0.3	0.3
Ovarian Cancer	0.3	0.5	1.1	-0.9	0.5	0.5	0.5	0.5	0.8	0.8	0.4	0.5	-0.4	0.8	1.0
Prostate Cancer	1.1	1.6	3.7	-0.6	-1.4	-0.4	-1.4	-1.9	-1.7	-1.4	-0.6	-1.5	-1.9	-0.2	0.0
Age at First Birth	0.6	0.9	3.4	1.7	0.9	1.9	0.8	0.5	-0.2	0.6	0.3	0.1	-0.3	0.3	1.4
Bipolar Disorder (2011)	1.0	1.0	4.0	2.0	-1.0	-1.7	-0.9	-0.4	-0.1	-0.5	-0.4	-0.4	0.5	-0.9	-1.2
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	0.4	0.2	-0.3	0.2	0.4	1.0	1.0	-0.1	0.4	-0.4	0.4	-0.2
Coronary Artery Disease (CAD)	0.7	0.8	1.9	-0.4	0.9	0.5	0.9	1.0	0.0	1.0	-0.8	1.2	1.0	0.9	1.4
Crohns Disease (2012)	0.4	0.6	2.7	-0.9	-0.4	0.2	-0.5	-1.0	0.2	-0.2	0.3	-0.8	-0.9	-0.9	-1.6
Mean Putamen Volume	0.5	0.6	1.8	0.2	-0.9	-0.4	-0.9	-1.1	0.4	-0.6	-1.3	-0.5	-1.3	-0.2	-0.5
Fasting Glucose	0.3	0.3	2.2	-0.5	-0.3	-0.1	-0.3	0.1	-0.2	-0.2	1.5	-0.0	0.9	0.0	0.7
HbA1C	1.4	1.5	4.7	-1.5	-0.9	-1.1	-1.0	-1.4	-1.3	-1.0	-0.5	-1.1	-1.0	-1.0	-2.2
HDL Cholesterol	0.1	0.2	1.1	-0.1	0.6	0.5	0.6	-0.1	0.2	0.2	-0.5	0.4	0.1	1.1	0.5
LDL Cholesterol	0.6	0.9	1.8	-1.1	-1.4	-1.2	-1.3	-1.0	-0.8	-1.1	-0.3	-0.9	-0.3	-0.6	-1.0
Lupus	0.2	0.3	1.2	0.9	0.4	0.2	0.4	0.3	0.1	0.3	-1.1	0.1	0.9	-0.5	0.2
Neuroticism (2016)	0.3	0.5	3.2	-1.8	-0.9	-0.1	-0.9	-0.6	-0.4	-0.0	0.2	-0.6	-0.1	-0.1	-0.0
Primary Biliary Cirrhosis	0.6	0.8	2.0	-0.1	1.0	1.3	1.0	1.2	0.4	0.3	-1.0	1.0	1.4	0.5	0.5
Rheumatoid Arthritis	0.4	0.6	1.7	-0.2	-0.8	-0.5	-0.8	-0.9	1.2	-0.8	-1.3	-0.3	0.1	0.5	0.9
Schizophrenia (2014)	0.9	1.9	3.6	1.9	-1.6	-1.7	-1.6	-0.8	-0.8	-1.6	0.1	-1.4	1.3	-1.8	-0.8
Triglycerides	0.2	0.3	1.1	-0.2	-0.1	-1.1	-0.1	1.1	-0.4	-0.4	0.8	0.3	0.3	-0.1	-0.2
Type 2 Diabetes (T2D) (2012)	3.4	3.9	9.4	0.3	2.4	3.1	2.3	1.5	2.7	2.1	-1.0	1.6	1.3	1.7	1.9
Ulcerative Colitis	0.3	0.5	1.3	-0.9	-0.7	0.1	-0.7	-1.1	0.7	-0.6	0.3	-0.7	1.1	-0.1	-0.5
Blood Eosinophil Count	0.1	0.6	4.0	0.2	-0.2	-2.0	-0.1	0.8	1.1	0.4	0.6	0.8	-0.4	0.4	-0.4
Blood Platelet Count	0.2	2.6	7.7	0.7	1.7	0.1	1.8	1.5	0.7	2.8	0.8	2.3	-1.3	2.5	0.9
Blood Red Count	0.3	2.8	6.9	2.2	-1.6	-2.6	-1.5	-0.9	-2.2	-0.6	0.8	-1.3	-0.2	-2.0	-2.1
Blood White Count	0.6	4.4	34.2	1.8	-1.6	-5.8	-1.4	-0.1	-1.8	-0.1	1.2	0.3	0.4	-0.7	-2.5
Heel T-Score	0.2	1.5	8.0	2.8	0.7	1.3	0.6	-0.5	0.2	1.1	-0.8	-0.5	1.5	-0.7	1.6
BMI	0.5	2.7	9.4	-3.1	-1.9	-2.5	-1.8	-1.8	-0.7	-0.5	-0.0	-0.6	-1.8	-0.9	-1.5
Height	0.2	4.8	18.7	-4.3	-1.9	2.0	-2.0	-2.3	0.1	-1.0	-2.0	-2.8	-2.0	-2.2	-0.0
Waist Hip Ratio (WHR)	0.3	1.6	12.2	-3.5	-0.2	0.3	-0.2	-0.6	0.1	0.4	1.4	-0.5	-1.3	-1.0	-1.0
Systolic Blood Pressure	0.7	3.4	11.9	3.3	-1.5	-3.4	-1.4	-0.7	-1.0	-1.2	1.8	-0.9	1.2	-1.2	-2.1
Smoking Status	0.6	1.4	3.8	-2.0	1.0	-0.0	1.1	1.7	0.1	1.5	0.5	1.6	0.1	1.2	0.9
Allergy or Eczema	0.4	1.1	2.9	-0.3	-1.0	1.1	-1.0	-0.5	1.0	1.0	1.1	-1.4	-1.2	-1.7	0.6
Cardiovascular Disease	0.6	1.9	8.1	-0.4	-1.1	-2.2	-1.1	-0.8	-1.0	1.1	2.8	-1.1	-0.9	-0.9	-1.0
Hypothyroidism (self reported)	0.3	0.7	3.4	0.2	0.4	-1.0	0.5	1.0	1.9	-0.6	0.2	1.0	-0.2	0.8	0.2
Respiratory disease	0.4	0.9	4.2	-1.5	0.2	-0.4	0.3	1.1	2.0	1.3	0.5	0.5	-0.4	0.1	0.4
Type 2 Diabetes (T2D) (2018)	1.0	2.0	8.4	-0.9	-1.9	-2.9	-1.8	-0.9	-0.2	-1.1	-0.4	-0.8	-1.4	-1.2	-1.2
Lung FEV1/FVC ratio	0.3	1.4	5.8	-1.7	0.2	1.4	0.1	-1.2	-0.1	1.0	-2.4	-0.4	-1.7	-0.1	0.7
Lung FVC	0.4	1.8	6.4	-1.0	1.2	2.5	1.2	-0.1	-0.1	1.0	-2.3	0.7	-0.4	1.5	1.7
Neuroticism	0.5	1.1	3.7	-1.9	0.5	1.6	0.5	0.7	0.6	1.2	0.1	0.2	1.7	-0.0	1.3
Chronotype (morning person)	1.9	4.4	10.0	0.1	2.8	3.2	2.8	1.8	1.6	0.5	-1.2	2.3	1.1	2.5	2.6
Hair Pigment	0.1	1.6	3.7	1.6	-1.4	-1.9	-1.4	-0.5	0.5	-1.6	1.7	-0.8	0.4	-1.1	-1.3
Tanning	0.1	0.9	4.9	-0.2	0.9	2.2	0.8	0.1	0.8	1.3	-1.2	0.1	-1.0	0.5	-0.1
Hand grip strength (left)	0.2	0.5	1.8	-0.1	0.4	0.7	0.4	-0.2	1.1	1.3	0.5	0.3	-0.8	0.9	0.2
Number of treatments/medications taken	0.5	0.9	3.7	0.9	-0.5	-1.9	-0.5	0.7	-0.2	0.9	0.9	-0.3	-1.0	-1.1	-1.3
Average weekly spirits intake	0.4	0.5	3.0	-1.7	-0.5	-1.0	-0.4	0.1	0.8	-0.1	-0.2	0.3	-0.6	0.3	0.4
Sensitivity / hurt feelings	0.3	0.5	3.3	-1.8	-0.7	0.1	-0.7	-0.1	0.2	0.4	1.2	-0.6	-0.1	-0.1	0.2
Frequency of depressed mood in last 2 weeks	1.0	1.4	5.6	-1.3	1.1	2.4	1.0	0.6	2.2	1.1	-0.3	0.3	0.8	0.1	0.8
Hearing difficulty/problems: Yes	0.3	0.5	2.4	-1.5	-0.5	0.1	-0.5	-0.0	1.1	0.2	0.5	-0.5	0.9	-0.8	0.6
Relative age of first facial hair	0.9	1.8	3.6	-0.5	-0.9	-0.1	-1.0	-1.9	-1.4	-0.2	-1.9	-1.7	-1.7	-1.5	-1.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	5.0	-0.9	-1.0	-0.9	-1.0	0.0	0.8	0.6	-0.0	-0.8	-2.2	-0.8	-0.9
Ever used hormone-replacement therapy (HRT)	0.8	1.1	4.1	0.2	0.7	0.8	0.6	-0.4	2.0	0.8	-1.1	-0.4	-1.2	-1.2	-1.5
Ever had hysterectomy (womb removed)	0.3	0.3	1.9	0.1	0.2	-0.1	0.3	0.6	1.4	-0.7	-0.3	0.5	-0.3	-0.3	-0.6
Systolic blood pressure, automated reading	0.9	2.5	7.7	1.5	-1.6	-2.8	-1.6	-1.4	-1.6	-1.6	0.4	-1.1	0.3	-1.5	-2.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	-1.0	-1.3	-1.3	-1.3	-1.2	-0.9	-0.3	-0.9	-0.8	-1.8	-0.3	-0.3
Angina	1.5	2.0	10.7	-0.7	-1.1	-1.9	-1.0	-0.5	-1.3	0.7	1.3	-0.6	-3.3	-0.7	-1.5
Medication for hormone replacement therapy	0.8	0.9	2.2	-0.5	-0.8	-0.8	-0.8	-1.1	0.1	-1.5	0.5	-0.8	-1.4	-0.9	-1.4
Vitamin and mineral supplements	0.4	0.5	1.3	0.4	0.8	0.2	0.9	0.9	0.9	0.2	-0.4	1.1	-0.4	0.8	0.7
Supplements: Zinc	1.8	1.9	9.2	-0.1	1.4	3.0	1.3	0.3	1.3	1.2	-1.8	0.5	0.9	0.9	1.4
Medication: Co-codamol	0.6	0.7	1.9	-0.5	-0.9	-0.3	-0.9	-0.7	0.7	0.4	-0.1	-0.8	-1.4	-1.3	-1.0
Medication: Metformin	1.7	2.4	6.6	-0.3	-1.7	-2.6	-1.7	-1.5	-1.7	-0.7	0.1	-1.0	-2.4	-1.1	-1.8
Diabetes (father)	0.4	0.5	1.3	-0.1	-0.1	-1.1	-0.1	0.2	-1.0	-0.2	1.1	0.4	-1.1	0.9	0.7
Diabetes (mother)	0.5	0.7	1.7	0.1	-1.2	-1.0	-1.1	-0.6	-0.2	0.1	-0.2	-0.9	0.6	-1.3	-1.0
Severe depression (siblings)	0.8	0.9	5.0	2.2	0.8	0.7	0.8	1.0	0.7	0.7	0.0	0.8	0.5	0.5	1.3
Pack years adult smoking proportion	0.9	1.4	4.7	0.1	-1.1	-2.2	-1.0	-0.8	-0.3	-2.1	-1.5	-0.2	-0.0	-0.3	-1.7
Impedance of leg (right)	0.5	2.2	4.7	1.4	-1.5	-1.4	-1.6	-1.4	0.1	-1.5	0.6	-2.1	-0.7	-2.2	-1.8
Leg fat-free mass (left)	0.5	2.8	18.7	-4.3	-1.7	-0.2	-1.6	-2.1	-0.2	-0.6	-1.0	-1.1	-1.5	-0.5	-0.1
Trunk fat percentage	3.0	11.9	21.0	-2.1	-4.5	-4.6	-4.4	-3.9	-1.0	-2.1	-1.1	-3.5	-3.9	-3.9	-3.6
Hand grip strength (right)	0.2	0.5	1.9	-0.1	0.2	0.4	0.2	-0.2	0.9	1.2	1.0	0.4	-0.4	1.4	0.8
Townsend deprivation index at recruitment	0.3	0.4	1.3	0.4	0.3	-0.9	0.4	1.0	-0.1	-0.0	0.0	1.1	0.7	0.3	-0.8
Current tobacco smoking	1.3	2.1	5.2	-0.6	1.7	-0.1	1.8	2.0	2.0	0.4	-0.5	2.3	1.1	1.7	0.6
Average weekly fortified wine intake	1.1	1.2	4.4	0.7	1.4	2.1	1.4	1.4	0.0	0.9	-1.3	0.7	0.7	0.3	0.7
Maternal smoking around birth	0.6	0.8	3.9	-0.7	-1.0	-1.5	-0.9	0.1	-0.8	-2.0	0.4	-0.1	0.3	-0.2	-0.3
Fed-up feelings	0.7	1.2	4.9	-2.2	1.1	1.8	1.0	0.1	1.4	1.3	0.1	0.3	0.5	-0.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.3	-1.5	1.1	0.4	1.2	1.2	1.8	0.4	-0.1	1.6	1.3	1.3	1.1
Relative age voice broke	0.9	1.4	4.9	1.2	-0.5	-0.8	-0.6	-1.0	-1.4	-0.6	-0.2	-1.3	-1.3	-1.7	-2.2
Taking other prescription medications	0.4	0.5	1.4	-0.3	-0.9	-0.7	-0.8	0.0	0.5	1.0	-0.3	-0.7	-1.2	-0.9	-0.7
Age when periods started (menarche)	0.2	0.5	1.4	1.2	-0.3	-0.8	-0.3	-0.6	-1.0	-0.5	0.9	-0.5	-0.5	-0.3	-0.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.7	-0.7	-0.7	-0.8	-0.6	-0.3	0.7	-1.6	-0.7	-0.3	-0.9	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	5.1	1.0	0.2	0.4	0.2	-0.3	1.1	0.2	0.4	-0.4	2.2	-0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.9	-0.0	-0.3	-0.2	-0.4	-0.4	0.4	1.7	-0.1	-0.7	-0.7	-1.3	-1.3
Qualifications: CSEs or equivalent	0.4	0.5	1.7	-1.3	0.5	1.1	0.5	-0.5	0.2	-0.9	-1.1	0.1	-0.1	0.2	0.2
Serious illness, injury or assault to yourself	1.4	1.7	8.2	2.9	0.9	0.5	0.9	1.3	2.0	1.7	-0.4	0.9	0.7	0.5	0.6
High blood pressure	0.8	2.1	3.8	-0.7	-1.9	-2.0	-1.9	-1.1	-1.1	-1.0	1.1	-1.4	-1.4	-1.5	-1.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.0	0.4	-0.0	1.7	-0.1	0.2	1.1	1.3	0.8	-0.9	-0.4	-1.3	0.7
Multivitamins +/- minerals	0.8	1.0	2.2	-0.5	-1.5	-0.6	-1.5	-1.3	-1.0	-0.4	0.3	-1.5	-0.1	-1.3	-0.9
Stomach or abdominal pain in last month	0.6	0.7	2.9	1.0	-0.3	-1.4	-0.3	0.6	-1.0	0.0	1.7	-0.2	1.0	-0.3	-0.0
Supplements: Glucosamine	1.0	1.3	4.2	-0.7	-0.8	0.7	-0.9	-1.0	-1.1	-0.1	2.0	-1.6	-1.2	-1.1	-1.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.6	0.5	0.0	0.5	-0.0	-0.2	-0.3	-0.4	-1.0	-0.3	1.3	-0.4	0.4
Medication: Atenolol	0.8	1.0	3.3	0.7	-0.4	-0.9	-0.5	-0.4	-1.2	0.4	-0.6	-0.6	-1.8	-1.2	-1.6
Medication: Levothyroxine sodium	0.3	0.6	3.1	0.1	-0.4	-0.9	-0.3	-0.1	0.7	-1.8	-0.6	0.3	-1.2	0.4	-0.5
Sitting height	0.2	1.5	6.5	-2.5	-0.2	2.1	-0.3	-0.8	0.1	-0.2	-0.7	-0.9	-0.4	0.1	2.1
Chronic bronchitis/emphysema (father)	2.1	2.5	4.7	0.6	-1.8	-2.2	-1.8	-1.7	-1.1	-0.4	1.1	-1.9	-1.0	-1.9	-2.2
High blood pressure (mother)	1.7	2.4	5.2	1.5	-1.7	-1.0	-1.7	-1.8	-1.0	-0.6	-1.5	-1.9	-1.2	-2.3	-1.8
Body mass index (BMI)	1.0	4.3	10.4	-2.5	-2.6	-3.2	-2.5	-2.3	-1.1	-0.6	-0.7	-1.2	-2.4	-1.4	-2.4
Impedance of leg (left)	0.6	3.0	5.9	1.6	-2.0	-1.9	-2.1	-1.4	-0.2	-1.9	0.4	-2.4	-1.0	-2.4	-1.8
Leg predicted mass (left)	0.5	2.7	18.0	-4.2	-1.6	-0.1	-1.6	-2.0	-0.1	-0.7	-1.1	-1.1	-1.5	-0.5	-0.1
Trunk fat mass	2.6	11.1	18.9	-3.0	-4.3	-3.9	-4.3	-4.0	-0.9	-1.9	-1.1	-3.4	-3.9	-3.6	-3.2
Waist circumference	2.1	7.9	18.8	-4.3	-3.5	-3.1	-3.4	-3.3	-1.0	-1.2	-0.4	-2.4	-3.0	-2.5	-2.8
Number of incorrect matches in round	0.3	0.4	2.5	-0.4	0.3	0.7	0.3	-0.1	-0.9	1.6	1.1	-0.2	0.2	-0.0	-0.1
Past tobacco smoking	0.5	1.0	5.9	2.4	0.2	0.3	0.2	-0.7	0.9	-1.1	-1.3	-0.5	0.4	-0.2	-0.9
Alcohol usually taken with meals	0.4	0.6	2.0	0.1	-0.5	0.4	-0.6	-1.2	0.0	1.0	-0.1	-1.0	-1.4	-0.6	-0.6
Nervous feelings	0.2	0.4	0.9	-0.5	-0.7	-0.1	-0.7	-0.1	-0.2	0.4	-0.5	-0.8	0.9	-0.9	-0.7
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	5.5	-0.4	1.5	2.4	1.4	1.4	2.0	0.7	-0.5	1.3	1.3	1.2	1.3
Hearing difficulty/problems with background noise	0.4	0.6	3.2	-0.6	-0.6	0.1	-0.7	-0.1	0.5	0.6	0.5	-1.3	0.2	-1.8	-0.5
Hair/balding pattern: Pattern 2	0.2	0.2	1.0	-0.7	-0.5	-0.3	-0.5	-0.2	-0.0	-0.7	-0.3	-0.2	-1.0	0.2	0.1
Had menopause	0.3	0.4	1.0	0.3	0.8	1.0	0.7	0.7	0.8	0.3	-0.2	0.4	-0.5	-0.4	-0.9
Had other major operations	1.0	1.2	3.9	-1.2	-0.3	0.2	-0.4	-0.9	1.2	0.3	-2.0	-1.0	-1.3	-1.5	-1.2
Forced vital capacity (FVC)	0.8	3.0	14.5	-2.7	1.1	3.8	1.0	0.0	1.2	1.3	-1.7	0.2	-0.3	0.9	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	4.6	1.3	-0.3	0.2	-0.3	-0.6	0.9	0.3	0.7	-0.8	2.1	-0.8	0.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	5.7	0.6	0.4	1.8	0.3	-0.3	1.2	1.2	-2.4	-0.3	1.3	-0.3	1.7
Qualifications: None of the above	1.7	3.7	7.1	-0.7	-1.8	-2.1	-1.8	-1.1	-2.2	-1.2	1.5	-1.8	-2.4	-2.6	-2.7
Financial difficulties in last 2 years	0.5	0.7	3.3	-1.8	0.6	-0.3	0.6	1.3	0.6	0.6	-0.2	0.9	0.5	0.5	-0.7
Mouth/teeth dental problems	0.4	0.7	2.4	0.2	-1.1	-0.1	-1.1	-0.5	0.1	-1.5	-1.3	-0.9	0.4	-0.1	0.6
Heart attack	0.6	0.8	3.5	0.4	-0.4	-1.9	-0.4	0.1	-0.3	0.5	1.2	-0.1	0.4	-1.1	-1.5
Allergy	0.2	0.6	1.6	0.9	0.5	-0.2	0.5	-0.4	-0.9	-1.2	-0.9	0.8	0.4	1.1	-0.3
Pain all over the body in last month	0.8	0.9	3.7	1.9	0.0	-0.3	0.1	0.4	0.6	0.2	-1.5	0.2	1.9	0.1	0.4
Diabetes (self-reported)	1.9	2.9	7.1	-0.9	-2.1	-2.7	-2.0	-1.4	-1.6	-1.1	0.8	-1.1	-2.6	-1.5	-1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.0	-0.2	0.1	1.1	-0.0	-0.9	1.1	0.7	-0.8	-0.8	0.9	-1.4	-0.1
Medication: Ramipril	1.2	1.6	6.9	-0.2	-1.0	-1.2	-1.0	-0.3	-1.8	0.5	2.6	-0.8	-0.1	-1.4	-1.5
Medication: Simvastatin	0.5	0.7	2.6	0.6	0.0	-1.3	0.1	-0.1	-1.6	-0.5	0.7	0.6	-1.2	0.3	-0.8
Fluid intelligence score	1.2	2.4	4.4	-0.8	1.8	2.1	1.8	0.7	2.0	1.3	-1.4	1.6	0.0	2.1	1.5
Illnesses of siblings	2.1	2.9	5.5	2.3	1.7	2.1	1.7	1.5	0.8	1.7	-1.0	1.3	1.8	2.3	1.7
Neuroticism score	0.3	0.6	2.9	-1.7	0.1	1.3	0.1	-0.1	0.1	0.7	0.0	-0.3	1.2	-0.4	0.8
Weight	1.5	7.1	16.7	-4.1	-3.4	-2.3	-3.3	-3.4	-0.9	-1.2	-1.2	-2.5	-3.1	-2.3	-2.1
Impedance of arm (right)	0.3	1.5	6.5	2.5	-0.5	-0.1	-0.6	-0.9	1.0	-0.9	-1.1	-1.5	0.5	-2.0	-0.4
Arm fat percentage (right)	1.8	7.2	16.1	-2.1	-3.4	-4.0	-3.4	-3.0	-1.1	-1.1	-1.2	-2.3	-2.9	-2.7	-2.9
Trunk fat-free mass	0.5	2.7	18.4	-4.3	-1.5	0.6	-1.5	-1.8	-0.2	-0.4	-1.1	-1.2	-1.6	-0.4	0.1
Hip circumference	1.6	6.8	12.4	-3.1	-3.4	-2.4	-3.3	-3.5	-1.1	-1.6	-1.3	-2.5	-3.1	-2.2	-2.2
Time employed in main current job	0.6	0.6	1.5	-1.1	-0.4	0.3	-0.4	-0.1	1.2	0.9	1.0	-0.5	-1.2	-0.9	-0.3
Alcohol intake versus 10 years previously	0.6	0.8	2.9	0.2	-1.0	-1.7	-0.9	-0.3	-1.2	-0.1	1.1	-0.4	0.4	-0.7	-1.2
Father’s age at death	2.4	3.2	8.4	-1.5	-1.9	-0.2	-2.0	-2.6	-1.2	-1.1	-0.2	-2.9	-0.7	-2.3	-2.0
Worrier / anxious feelings	0.3	0.6	2.2	0.0	0.5	1.5	0.4	1.0	0.8	0.3	0.2	0.2	1.3	0.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	3.8	-2.0	-0.2	-0.4	-0.2	0.7	0.8	0.0	-0.5	0.5	-1.4	-0.2	-0.5
Falls in the last year	0.7	0.9	2.4	0.7	0.7	-0.3	0.8	1.1	1.0	0.5	0.3	1.6	-0.2	1.4	1.5
Hair/balding pattern: Pattern 3	2.2	3.2	5.9	0.2	2.2	1.1	2.2	2.4	1.5	0.8	1.6	2.4	1.9	2.2	1.4
Number of live births	0.9	1.3	3.3	1.0	-1.1	-1.7	-1.0	-0.6	-1.8	-1.8	-0.1	-0.4	-0.5	-0.4	-1.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	11.0	-2.4	0.7	3.3	0.6	-0.6	1.0	1.3	-2.1	-0.1	-0.4	0.8	2.1
Pulse rate	2.8	4.8	8.4	1.2	2.2	2.2	2.2	2.3	2.8	2.4	-1.0	2.1	2.9	2.0	2.1
Happiness	0.3	0.4	1.6	0.3	0.4	1.3	0.3	-0.3	0.6	0.2	-1.2	-0.0	0.5	-0.4	0.9
Noisy workplace	0.2	0.3	1.2	0.6	0.1	0.6	0.1	0.2	0.2	-0.1	-1.1	-0.0	-0.2	-0.6	-0.8
Qualifications: A levels/AS levels or equivalent	1.6	3.6	12.1	0.5	2.0	3.5	2.0	1.4	1.1	0.8	0.3	1.5	1.8	2.3	2.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	6.7	-2.6	-0.6	0.9	-0.7	-1.3	0.2	-0.3	-0.3	-1.3	0.3	-1.2	-1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	3.1	-0.8	0.4	-0.1	0.4	-0.2	0.4	-0.8	-0.7	0.4	0.5	-0.5	-1.8
Asthma	0.3	0.6	3.9	-2.0	-0.6	-1.2	-0.6	0.2	0.4	-0.3	0.8	-0.3	-0.2	-0.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.9	-0.6	-0.4	0.1	-0.4	0.0	-0.9	1.1	1.7	-1.0	-1.3	-0.5	-0.2
Medication: Cholesterol lowering	0.5	0.8	3.3	0.2	-0.3	-1.8	-0.2	0.1	-1.8	0.3	0.3	0.4	-1.2	-0.3	-0.8
Depression (self-reported)	1.5	1.8	4.5	0.3	-2.1	-1.3	-2.1	-1.4	-0.3	-1.3	-0.1	-1.6	-0.7	-1.4	-1.3
Medication: Lansoprazole	0.7	0.8	4.0	0.8	0.4	0.4	0.5	1.1	1.1	-0.2	-2.0	0.9	0.3	0.6	0.4
Prospective memory result	0.4	0.4	1.5	-0.8	-0.7	-0.6	-0.7	-0.0	0.5	-0.3	1.2	-0.6	-0.1	-0.7	-0.8
Lung cancer (father)	1.1	1.3	3.0	0.9	-0.6	-1.4	-0.7	-0.3	-0.2	0.6	1.7	-0.8	-1.7	-1.4	-1.5
Illnesses of mother	2.5	3.1	7.5	-1.2	2.0	1.8	2.0	1.6	1.0	-0.5	-0.6	2.2	0.9	2.7	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	13.0	-2.1	1.4	3.6	1.3	-0.2	2.0	1.7	-2.8	0.5	0.5	1.4	2.8
Pulse wave Arterial Stiffness index	2.5	2.9	7.7	-0.4	-2.2	-2.6	-2.2	-1.2	-0.7	-1.9	2.8	-1.3	-0.6	-1.4	-1.1
Impedance of arm (left)	0.3	1.5	4.1	1.6	-0.9	-0.3	-1.1	-1.4	0.4	-1.6	-0.7	-1.9	-0.2	-2.0	-0.4
Arm fat mass (right)	1.6	6.6	10.8	-3.3	-3.3	-3.2	-3.2	-3.1	-0.8	-1.1	-1.2	-2.2	-2.9	-2.2	-2.5
Trunk predicted mass	0.5	2.7	18.3	-4.3	-1.5	0.6	-1.5	-1.9	-0.2	-0.5	-1.2	-1.2	-1.7	-0.4	0.1
Standing height	0.4	4.1	14.0	-3.7	-1.9	1.6	-2.0	-2.5	0.7	-1.6	-1.4	-2.7	-1.5	-1.9	0.5
Length of working week for main job	1.0	1.1	6.7	-2.6	0.8	1.0	0.7	-0.5	1.1	-1.1	-0.2	0.4	1.3	0.6	0.4
Exposure to tobacco smoke at home	0.7	0.8	4.6	0.3	-0.8	-0.8	-0.8	-0.6	-2.1	0.2	-0.3	-0.8	-0.7	-0.4	-0.9
Breastfed as a baby	0.4	0.5	2.4	-0.2	-0.9	-1.6	-0.8	-0.3	-0.5	-0.6	0.2	-0.2	0.5	-0.0	1.1
Tense / ‘highly strung’	0.7	1.1	5.3	0.1	0.8	0.8	0.9	2.3	-0.2	0.7	0.1	1.4	1.1	0.9	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.9	-0.2	-0.3	0.8	-0.4	-0.1	1.1	1.5	0.0	-0.9	0.7	-1.7	-0.5
Hair/balding pattern: Pattern 4	0.1	0.3	1.2	-0.1	-0.1	0.1	-0.1	0.1	-1.1	0.8	0.2	-0.0	0.7	-0.7	-0.5
Birth weight of first child	1.4	2.6	11.4	-0.6	-1.8	-0.6	-1.8	-1.3	-1.2	-1.1	-0.1	-1.9	-3.4	-1.9	-1.1
Peak expiratory flow (PEF)	0.3	0.6	2.3	-1.1	-0.1	0.8	-0.2	-1.1	-0.7	0.9	0.2	-0.4	-1.5	0.4	0.7
Pulse wave reflection index	4.5	5.6	8.0	-0.8	-2.8	-2.7	-2.8	-2.3	-1.7	-2.5	1.8	-2.5	-2.3	-2.8	-2.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.5	0.2	-0.6	-0.1	-0.7	-0.9	-1.2	-0.2	0.3	-1.1	0.8	-1.0	0.3
Loud music exposure frequency	2.0	2.2	4.6	0.7	-1.9	-1.5	-1.9	-1.7	-0.5	-1.2	-0.6	-1.9	0.5	-2.1	-1.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.8	-0.2	0.9	1.4	0.9	0.6	2.0	1.0	-0.3	0.9	0.4	1.6	2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	4.9	0.4	0.9	0.4	0.9	0.5	-0.3	2.2	1.9	0.6	-0.1	1.0	-0.1
Blood clot in the leg (DVT)	0.3	0.4	1.9	-0.3	-0.2	-0.4	-0.2	0.1	1.4	0.9	-0.9	-0.3	-0.4	0.1	-0.5
Medication: Paracetamol	0.6	0.9	3.0	0.2	-0.5	-0.6	-0.6	-0.4	0.3	1.2	1.7	-1.1	0.7	-1.7	-1.0
Headache pain in last month	0.6	1.0	5.4	1.6	0.2	-1.0	0.2	0.7	-0.1	-1.2	0.6	0.5	2.3	0.2	0.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	6.1	-0.6	1.4	2.5	1.3	0.6	2.3	0.2	-1.0	0.8	0.7	1.3	1.6
Glaucoma (self-reported)	1.2	1.4	3.0	0.3	-1.7	-0.4	-1.7	-1.6	0.3	-1.4	-1.0	-1.7	-0.6	-1.3	-0.2
Gout (self-reported)	0.8	1.1	2.0	-0.5	1.3	1.3	1.2	0.8	-0.6	1.4	0.9	0.9	-1.3	1.0	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	2.8	-0.1	0.2	-0.5	0.3	0.2	1.7	-0.8	-0.8	0.5	-0.9	0.3	-0.2
Medication: Amlodipine	0.3	0.4	1.3	0.3	-0.3	-0.7	-0.4	0.1	-0.9	-0.2	0.5	-0.4	0.5	-1.1	-1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.8	-0.1	-0.6	-1.4	-0.6	0.1	-0.5	-1.3	1.0	-0.2	0.4	-0.1	0.0
Birth weight	0.5	1.0	6.3	-2.5	-0.5	0.5	-0.5	-1.2	-0.9	0.4	-0.3	-0.8	-1.0	-0.7	-0.3
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.9	0.2	-0.0	-0.9	0.0	0.9	0.9	-0.8	0.9	0.5	0.9	-0.1	-0.7
High blood pressure (siblings)	3.5	5.0	9.5	-1.2	-2.9	-2.6	-2.9	-2.7	-1.5	-1.5	0.5	-2.6	-1.8	-3.1	-2.0
Forced vital capacity (FVC), Best measure	1.1	3.9	14.8	-2.4	1.5	3.9	1.4	0.1	2.1	1.7	-2.3	0.5	0.2	1.3	2.7
Body fat percentage	3.0	11.7	22.5	-2.1	-4.5	-4.7	-4.4	-3.9	-1.1	-2.0	-0.9	-3.3	-3.8	-3.7	-3.8
Leg fat percentage (right)	3.1	11.3	21.0	-2.4	-4.2	-4.6	-4.2	-3.9	-1.4	-1.5	-0.3	-3.3	-3.6	-3.7	-4.1
Arm fat-free mass (right)	0.7	3.8	19.4	-4.4	-2.2	-0.5	-2.1	-2.2	-1.0	-1.1	-0.8	-1.6	-2.3	-0.7	-0.6
Exposure to tobacco smoke outside home	2.6	3.5	5.9	-1.1	-2.3	-2.4	-2.3	-2.4	-1.6	-1.4	0.4	-2.0	-0.1	-2.3	-2.1
Comparative body size at age 10	0.1	0.2	0.6	-0.8	0.4	0.6	0.4	-0.1	0.2	0.6	0.3	0.3	0.6	0.3	0.2
Number of full brothers	0.3	0.4	1.7	-1.3	-0.2	-0.4	-0.2	0.0	-0.5	-0.9	-0.5	0.2	-0.9	-0.6	-0.7
Worry too long after embarrassment	2.0	3.3	6.6	-2.0	-2.6	-2.2	-2.6	-2.0	-1.5	-1.9	1.1	-2.2	-0.4	-1.3	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.7	-0.5	-0.8	-1.0	-0.8	-0.5	0.2	0.2	-0.4	-0.8	-0.3	-1.4	-1.6
Wheeze or whistling in the chest in last year	0.6	1.0	3.2	-1.2	-0.6	-1.3	-0.6	-0.2	1.5	0.2	0.4	-0.4	1.1	-0.9	-1.8
Number of children fathered	0.8	0.9	1.8	-0.7	1.1	0.9	1.1	1.3	1.2	0.8	-0.4	1.3	0.6	0.9	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.1	-0.1	0.5	0.7	0.5	0.2	1.1	1.4	1.0	0.4	-0.3	0.3	0.6
Age at first live birth	0.7	1.2	4.4	1.7	0.5	2.1	0.5	0.3	0.4	-0.9	-1.3	0.3	0.5	1.1	1.4
Pulse wave peak to peak time	2.6	3.1	8.2	0.1	2.3	2.9	2.2	1.1	0.9	2.1	-2.7	1.2	0.5	1.4	1.4
Health satisfaction	0.6	0.8	2.6	-0.0	0.9	-0.2	1.0	1.3	1.1	1.6	-0.4	1.3	-0.0	0.7	0.3
Shortness of breath walking on level ground	0.8	1.0	4.7	-0.5	-1.3	-2.2	-1.2	-0.0	-0.0	0.7	0.0	-0.5	-0.8	-0.9	-1.2
Qualifications: College or University degree	0.3	1.1	5.1	0.6	0.1	2.3	0.1	0.0	0.8	-1.0	-2.0	-0.1	0.2	0.3	1.3
Eye problems/disorders: None of the above	3.8	4.4	12.0	3.2	1.9	0.1	2.0	2.9	1.2	1.4	1.6	2.2	3.5	1.4	1.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.2	-0.6	1.0	0.0	1.1	1.7	-1.6	0.4	1.2	1.8	0.3	1.6	0.7
Emphysema/chronic bronchitis	0.8	0.9	3.8	-0.2	-0.1	-1.9	0.0	1.4	-0.0	1.3	-1.2	0.9	-1.0	0.2	-0.1
Medication for pain relief, constipation, heartburn	0.8	1.4	5.7	0.4	0.7	0.9	0.8	0.2	1.2	-1.0	-2.4	1.0	0.8	1.8	1.3
Neck or shoulder pain in last month	0.3	0.4	1.8	-1.4	-0.1	1.1	-0.1	-0.4	-0.3	0.2	0.0	-0.5	-1.0	-0.5	-0.2
Medication: Blood pressure	1.9	3.3	6.4	1.1	-2.2	-2.5	-2.2	-1.3	-2.5	-1.2	0.6	-1.7	-1.3	-2.1	-2.0
Angina (self-reported)	1.3	1.8	10.2	-0.9	-0.7	-1.5	-0.7	-0.3	-1.3	0.8	1.4	-0.3	-3.2	-0.4	-1.5
Migraine (self-reported)	0.6	0.8	2.9	1.7	0.3	-0.3	0.3	-0.2	1.0	-0.8	-0.5	0.3	1.5	1.1	1.0
Medication: Ibuprofen	0.6	0.7	4.3	-0.4	-0.2	0.1	-0.2	0.6	-1.2	1.0	2.1	-0.6	-1.0	-0.1	0.3
Medication: Allopurinol	0.5	0.7	3.2	-0.1	0.4	1.0	0.3	-0.5	-0.3	1.8	1.3	-0.6	-0.6	-0.9	-0.3
Medication: Omeprazole	1.2	1.4	2.3	0.8	-1.5	-1.3	-1.5	-0.9	-1.4	-1.5	-1.1	-1.0	-0.1	-1.3	-1.2
Medication: Seretide 50 evohaler	0.8	0.9	2.1	-0.3	-1.1	-1.1	-1.2	-0.8	-0.1	1.3	0.8	-1.4	-0.2	-1.2	-0.6
Mean time to correctly identify matches	0.2	0.4	1.5	0.0	-0.7	-1.2	-0.6	0.8	0.0	-0.4	-0.1	0.5	-0.9	0.4	0.0
Heart disease (mother)	0.5	0.6	1.4	-0.1	-0.0	-0.3	-0.1	0.0	1.0	1.2	-1.2	-0.4	1.0	-1.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.6	0.9	-0.7	-0.3	-0.8	-0.9	-1.6	0.7	0.4	-1.2	-0.9	-1.0	-0.3
Whole body fat mass	2.5	10.4	18.0	-3.1	-4.2	-4.0	-4.2	-3.9	-1.1	-1.9	-0.8	-3.2	-3.6	-3.3	-3.1
Leg fat mass (right)	2.4	9.3	15.4	-3.5	-3.9	-3.7	-3.9	-3.8	-1.1	-1.6	-0.4	-2.9	-3.2	-3.0	-3.0
Arm predicted mass (right)	0.8	3.8	19.0	-4.4	-2.2	-0.5	-2.2	-2.3	-1.1	-1.2	-0.9	-1.6	-2.2	-0.8	-0.7
Pulse rate, automated reading	0.4	1.4	2.3	0.7	0.8	0.9	0.9	1.3	1.0	0.9	-1.5	1.4	1.4	1.4	1.4
Alcohol intake frequency.	0.6	1.3	6.8	1.7	-1.1	-2.6	-1.0	0.6	-0.1	-0.6	0.2	0.0	0.5	-0.8	-1.6
Comparative height size at age 10	0.4	2.0	12.0	-3.5	-1.2	1.3	-1.2	-1.4	1.0	-1.5	0.5	-1.1	-0.2	-0.4	1.0
Number of full sisters	1.5	1.8	7.4	-2.5	-1.2	-0.8	-1.2	-1.1	-1.0	-1.0	-0.1	-0.6	-2.7	-0.1	-0.9
Suffer from ‘nerves’	0.2	0.4	2.1	0.6	0.7	0.6	0.6	0.1	-1.4	-0.2	-0.4	0.1	0.2	-0.4	-0.6
Overall health rating	1.2	2.5	14.1	-0.9	-1.9	-3.8	-1.8	-0.0	0.4	-0.2	0.5	-0.3	-0.7	-1.5	-2.4
Chest pain or discomfort	0.9	1.4	9.7	-0.7	0.6	0.8	0.5	0.6	1.7	3.1	0.3	0.4	-0.8	0.6	0.7
Had major operations	0.6	0.7	2.2	-0.0	-0.0	1.3	-0.1	-0.5	0.1	1.0	-1.4	-1.0	-0.1	-1.5	-0.7
Age at last live birth	1.5	2.2	7.7	2.8	0.7	1.3	0.7	1.0	0.4	-0.7	-1.6	1.1	1.0	2.0	2.3
Family relationship satisfaction	1.3	1.5	2.5	-0.7	1.4	1.3	1.5	1.4	1.1	1.3	0.2	1.6	1.2	1.2	1.5
Leg pain on walking	0.6	0.7	2.0	-0.5	-0.9	-0.7	-0.9	-0.7	0.1	0.1	0.2	-1.1	-1.1	-1.4	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	-1.0	0.1	-0.2	0.1	0.0	-0.2	0.6	1.1	0.5	-1.1	0.8	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.4	-0.7	-0.9	-0.6	-0.0	-0.0	-0.6	0.2	-0.3	-0.7	-0.0	0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.1	-0.8	0.1	-0.4	0.2	0.4	-0.0	-0.7	-0.7	0.8	-0.1	1.1	1.4
Medication: Aspirin	0.7	0.9	2.5	0.1	0.7	-0.1	0.8	1.4	-0.1	1.5	1.4	1.0	-1.6	0.2	-0.5
Supplements: Vitamin C	0.4	0.5	2.7	-0.8	0.0	0.8	-0.0	-0.5	-0.6	0.8	1.6	-0.6	-0.3	-0.1	-0.3
Knee pain experienced in last month	1.3	2.1	5.6	-0.7	-1.7	-1.5	-1.7	-1.3	-0.6	0.2	1.0	-2.0	-0.6	-2.4	-1.8
Hypertension (Self-reported)	0.9	2.6	4.5	-0.9	-1.9	-2.1	-1.9	-1.1	-1.1	-0.6	1.6	-1.5	-1.9	-1.7	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	4.2	1.7	0.9	1.5	0.9	0.5	1.4	1.2	-2.1	0.8	1.6	0.3	1.0
Illnesses of father: Heart disease	0.5	0.7	1.8	0.1	-0.9	-0.1	-1.0	-0.8	-0.8	0.6	1.3	-1.2	-0.7	-0.9	-0.6
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.8	0.7	-0.5	0.7	0.9	-0.4	0.8	0.5	0.7	0.8	-0.4	-0.1
Smoking status: Previous	0.8	1.2	4.4	-2.1	-1.0	-0.5	-1.0	-0.3	-1.9	0.1	1.3	-0.5	-1.2	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.6	-0.5	-0.7	-0.3	-0.7	-0.3	1.2	-1.1	-0.7	-0.5	0.8	-0.4	0.3
Whole body fat-free mass	0.5	3.0	19.7	-4.4	-1.7	0.1	-1.7	-2.1	-0.1	-0.6	-1.1	-1.3	-1.7	-0.6	-0.1
Leg fat-free mass (right)	0.5	2.6	16.9	-4.1	-1.6	-0.1	-1.6	-1.9	-0.2	-0.6	-1.1	-1.0	-1.4	-0.4	0.2
Arm fat percentage (left)	2.0	8.1	16.1	-2.2	-3.7	-4.0	-3.6	-3.4	-1.6	-1.5	-1.0	-2.5	-3.2	-2.7	-2.9
Average weekly red wine intake	1.3	2.0	7.6	-1.4	1.0	2.1	1.0	0.5	0.1	2.0	1.3	0.5	-2.8	0.7	0.9
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.6	-0.4	0.9	0.3	0.9	1.6	0.3	1.5	0.5	1.2	-0.1	0.6	0.7
Mood swings	0.4	0.8	3.6	-0.1	0.0	0.9	-0.1	-0.0	1.9	1.1	-0.6	-0.6	1.4	-1.0	0.3
Loneliness, isolation	0.2	0.3	2.1	0.1	0.1	0.6	0.1	0.6	0.4	-0.1	-0.7	0.3	1.5	-0.1	0.6
Long-standing illness, disability or infirmity	5.1	7.7	14.4	-1.7	-3.8	-3.4	-3.7	-2.4	-0.1	-1.4	-0.6	-3.1	-3.3	-3.5	-3.1
Ever had bowel cancer screening	0.5	0.6	4.4	-1.2	-0.4	-0.1	-0.4	0.4	-0.2	-0.0	2.1	-0.3	0.3	-0.3	0.5
Diabetes diagnosed by doctor	2.8	4.6	12.6	-0.2	-2.9	-3.6	-2.8	-1.9	-1.9	-1.6	0.3	-1.7	-2.6	-2.0	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	3.0	0.5	-0.7	-1.7	-0.7	-0.6	-0.5	-1.1	-0.3	-0.4	-0.4	-0.3	-0.9
Friendships satisfaction	3.8	4.7	8.9	-0.1	2.4	2.9	2.4	2.1	2.4	2.4	-0.1	2.3	1.0	2.3	3.0
Qualifications: nursing, teaching	0.5	0.8	3.3	-0.3	0.1	1.8	0.0	-0.6	0.7	-1.1	-1.2	-0.2	-1.1	0.5	1.1
Commuting to job workplace: Walk	0.6	0.7	2.3	1.1	0.2	-0.1	0.3	0.5	-1.5	-1.3	-0.7	0.6	1.0	0.6	0.1
Eye problems/disorders: Cataract	1.6	1.8	5.4	-1.6	-1.3	0.0	-1.4	-2.3	-1.2	-0.5	-0.6	-1.7	-1.7	-1.2	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.6	-0.8	-0.0	-0.2	0.0	0.5	-0.4	1.1	1.5	0.1	-1.9	-0.4	-0.1
Medication for cholesterol	0.3	0.4	2.5	-0.3	-0.4	0.5	-0.4	-0.2	-1.6	0.2	0.0	-0.6	0.9	-0.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	-0.2	-0.7	-0.3	-0.7	-0.5	0.5	0.3	-0.5	-1.0	0.1	-0.8	-0.4
Back pain experienced in last month	0.5	0.7	4.8	-2.2	-0.1	-0.2	-0.1	0.6	0.5	0.2	1.7	0.3	0.2	-0.3	0.0
Mineral and other dietary supplements	1.5	2.0	5.1	1.1	1.5	0.3	1.5	1.3	1.9	1.1	-1.2	1.6	2.3	1.0	1.3
Breast cancer (self-reported)	1.1	1.3	2.5	-0.8	-1.5	-1.6	-1.5	-1.1	-1.5	-0.8	0.5	-1.1	-1.3	-0.9	-0.7
Asthma (self-reported)	0.3	0.7	5.1	-2.2	-0.5	-0.9	-0.5	0.3	0.7	-0.1	0.8	-0.3	-0.4	-0.2	0.0
Osteoporosis (self-reported)	1.7	2.1	5.7	0.4	-1.8	-2.4	-1.7	-1.4	-1.6	-0.9	-0.5	-1.3	-1.4	-1.3	-1.4
Osteoarthritis (self-reported)	1.1	1.4	2.5	-0.7	-1.5	-0.5	-1.5	-1.5	-0.3	-1.0	-0.9	-1.4	-0.6	-1.6	-1.5
Medication: Aspirin	0.6	0.8	2.3	0.5	0.8	0.1	0.8	1.3	-0.1	1.5	1.0	1.0	-1.3	0.4	-0.5
Medication: Gliclazide	3.2	3.6	6.4	-1.1	-2.4	-2.1	-2.3	-2.0	-2.1	-2.5	-1.8	-1.7	-0.9	-1.6	-1.3
Illnesses of father: None of the above (group 1)	1.0	1.3	5.1	0.2	1.1	0.7	1.1	1.0	1.2	-0.7	-2.3	1.3	1.3	0.7	0.8
Smoking status: Current	1.4	2.3	5.0	-0.3	1.8	0.2	1.9	2.2	2.0	0.9	-0.5	2.2	1.4	1.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	10.2	-0.3	2.0	3.0	2.0	1.0	1.6	1.6	-2.9	1.9	1.4	2.7	3.2
Whole body water mass	0.5	3.1	20.0	-4.5	-1.8	0.0	-1.8	-2.1	-0.3	-0.6	-1.1	-1.3	-1.8	-0.5	-0.1
Leg predicted mass (right)	0.5	2.7	17.6	-4.2	-1.7	-0.2	-1.7	-1.9	-0.3	-0.7	-1.1	-1.0	-1.5	-0.4	0.1
Arm fat mass (left)	1.7	7.0	11.4	-3.3	-3.4	-3.3	-3.3	-3.2	-1.2	-1.3	-1.1	-2.3	-3.0	-2.3	-2.6
Number of self-reported non-cancer illnesses	2.6	4.5	7.6	-0.7	-2.7	-2.3	-2.8	-1.9	-1.2	0.3	0.5	-2.7	-2.6	-2.8	-2.6
Average weekly champagne plus white wine intake	1.9	2.6	4.6	1.7	1.9	1.6	1.8	1.6	-0.8	2.1	-0.2	1.2	2.1	1.7	1.6
Miserableness	0.5	0.9	7.2	-2.7	0.0	0.3	0.0	0.3	0.6	-0.0	1.4	0.1	-0.3	-0.1	1.0
Guilty feelings	2.8	4.1	9.0	-1.7	-2.3	-1.1	-2.4	-2.4	-1.3	-0.6	2.1	-2.9	-0.8	-3.0	-2.0
Wears glasses or contact lenses	0.8	0.9	3.8	0.6	1.1	1.9	1.1	0.6	-0.7	0.1	-1.5	0.6	0.3	0.6	0.6
Ever taken oral contraceptive pill	0.5	0.6	2.2	-0.8	0.1	0.2	0.1	0.2	1.2	0.9	1.5	0.4	-0.3	0.9	0.7
Hearing aid user	3.8	4.3	10.4	0.4	-2.4	-1.2	-2.5	-2.2	-0.8	-1.9	-1.5	-2.6	-3.2	-2.5	-1.7
Mother’s age at death	0.8	1.0	3.0	-1.4	-0.4	0.3	-0.4	-0.9	-1.6	-0.2	1.7	-0.5	-1.6	-0.5	0.2
Financial situation satisfaction	0.3	0.4	2.5	-1.6	0.2	-0.0	0.2	0.3	-0.1	0.7	1.0	0.4	0.0	-0.1	0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.7	-0.1	-0.7	0.2	-0.7	-0.7	-1.6	-0.8	-0.2	-1.0	-1.3	-0.8	-0.6
Commuting to job workplace: Public transport	0.2	0.2	0.8	-0.3	0.3	0.9	0.3	-0.3	0.2	0.7	-0.3	-0.1	-0.3	0.2	-0.3
Eye problems/disorders: Glaucoma	1.8	2.1	4.4	0.0	-2.1	-0.8	-2.1	-1.9	0.1	-1.9	-1.3	-1.9	-0.7	-1.6	-0.9
Medication: Blood pressure	0.4	0.8	2.1	0.2	1.0	0.1	1.1	1.2	1.5	1.1	0.2	1.2	-0.7	0.4	-0.7
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.2	-1.5	-0.4	-1.7	-0.4	0.1	0.4	1.4	2.1	-0.1	-0.8	-0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.6	-0.5	-0.7	0.3	-0.7	-0.7	-1.2	0.1	0.7	-1.2	-1.3	-1.1	-0.8
High cholesterol (Self-reported)	0.4	0.8	3.1	1.8	0.8	-0.9	0.9	0.9	-0.7	0.6	-0.3	1.0	1.0	0.5	0.2
Medication: Bendroflumethiazide	0.3	0.5	1.9	1.3	-0.3	-0.7	-0.3	0.5	0.6	0.5	1.4	-0.1	-0.1	-0.2	-0.9
Medication: Paracetamol	0.5	0.8	5.2	0.2	-0.4	-0.4	-0.4	0.1	-0.4	0.9	2.3	-0.6	0.8	-1.3	-0.7
Medication: Lisinopril	0.6	0.7	1.8	0.2	-0.9	-1.3	-0.9	0.1	-1.1	-0.9	-0.2	-0.2	-1.3	-0.3	-1.1
Medication: Atorvastatin	0.8	0.9	3.8	1.1	-1.0	-1.0	-1.0	-0.5	0.2	0.5	0.6	-1.0	-0.4	-2.0	-1.1
Illnesses of father: High blood pressure	0.2	0.3	1.3	-1.2	-0.6	-0.0	-0.6	-0.4	-0.4	0.0	0.6	-0.5	0.1	0.2	-0.2
Alcohol drinker status: Never	2.8	3.3	24.2	4.9	-1.0	-2.2	-0.9	-0.5	-0.6	-1.4	-2.2	-0.3	0.8	-0.3	-0.5
Ever smoked	1.0	1.7	9.0	-3.0	0.6	0.7	0.7	1.4	0.1	0.9	0.7	1.4	0.5	1.3	1.8
Basal metabolic rate	0.7	3.8	20.5	-4.5	-2.2	-0.5	-2.2	-2.4	-0.4	-0.8	-1.1	-1.6	-2.1	-0.9	-0.5
Leg fat percentage (left)	3.6	12.9	24.1	-2.6	-4.6	-4.9	-4.6	-4.0	-1.8	-1.9	-0.3	-3.5	-4.0	-3.9	-4.1
Arm fat-free mass (left)	0.6	3.1	15.1	-3.9	-2.0	-0.3	-1.9	-2.1	-0.6	-0.8	-1.2	-1.4	-2.2	-0.7	-0.6
Number of operations (self-reported)	1.5	2.3	6.4	-0.3	-0.7	-0.3	-0.8	-1.2	1.2	0.9	-2.2	-1.5	-1.7	-2.5	-2.3
Average weekly beer plus cider intake	0.9	1.3	4.3	-2.1	-1.0	-1.6	-1.0	-0.6	-0.1	-1.2	1.1	-0.2	0.6	-0.9	-1.6
Irritability	0.3	0.5	2.3	-0.1	0.1	0.9	0.1	0.7	0.8	0.4	0.9	0.1	1.5	-0.1	0.7
Risk taking	0.2	0.2	0.7	0.6	0.1	-0.5	0.1	0.5	-0.3	0.8	0.8	0.0	-0.5	0.1	0.6
Ever had prostate specific antigen (PSA) test	1.9	2.1	4.9	-0.1	1.9	1.9	1.8	2.1	0.9	2.2	0.2	1.5	0.0	1.1	1.2
Fractured/broken bones in last 5 years	0.2	0.3	1.6	0.3	0.3	0.7	0.3	0.0	0.8	-0.1	-1.3	0.2	-0.2	-0.2	-0.4
Age started oral contraceptive pill	0.9	1.1	6.5	-0.4	-0.9	-0.2	-0.9	-0.6	-0.6	-0.5	-0.5	-0.9	-2.5	-1.3	-1.2
Diastolic blood pressure, automated reading	0.4	1.3	2.6	-0.5	-1.4	-1.5	-1.4	-1.6	-0.7	-1.6	-0.8	-1.0	0.7	-0.8	-1.1
Ever depressed for a whole week	0.6	0.8	2.5	1.6	-0.2	0.6	-0.3	-0.5	0.3	1.3	-0.5	-0.8	1.4	-1.0	0.3
Unable to work because of sickness or disability	1.4	1.9	9.9	1.3	-1.4	-3.1	-1.3	0.1	0.3	-0.4	-0.1	-0.4	-0.6	-1.4	-2.0
Commuting to job workplace: Cycle	0.4	0.5	2.7	-1.3	0.5	1.6	0.4	-0.2	0.5	-0.1	0.8	-0.2	0.7	-0.0	0.0
Myopia	1.2	1.7	6.6	1.2	-1.0	-1.1	-0.9	-0.6	-2.6	-2.2	-2.0	-0.6	-0.1	0.3	-0.2
Vascular/heart problems diagnosed by doctor	1.0	2.6	5.9	0.6	1.8	2.2	1.8	1.3	1.1	0.8	-1.5	1.4	1.8	1.8	2.4
Cholesterol lowering medication	0.3	0.5	2.1	0.3	-0.6	-1.5	-0.6	-0.4	-0.2	-1.2	0.6	0.0	-0.6	-0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	5.2	1.2	-2.3	-2.1	-2.2	-1.1	-1.9	-1.4	-0.2	-1.5	-0.8	-2.0	-1.9
Pain experienced in last month	0.8	1.3	5.2	0.8	0.9	1.6	0.9	0.7	0.0	1.0	-2.3	0.8	-1.3	1.1	0.9
Supplements: Calcium	0.9	1.0	2.1	1.4	0.8	-0.8	0.8	1.4	-0.8	0.8	0.8	1.1	0.4	1.2	1.0
Basal cell carcinoma (self-reported)	0.9	1.0	2.7	0.9	1.2	0.6	1.2	1.1	1.0	1.6	-0.7	1.0	-0.6	0.7	-0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.9	0.3	-0.4	-1.7	-0.4	-0.0	-0.3	0.4	1.0	-0.2	0.3	-1.0	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.5	-0.6	-0.5	-0.6	-0.5	0.9	0.7	-0.7	-0.8	-0.5	-0.4	-0.8
Heart disease (siblings)	1.7	2.1	7.2	-2.4	-1.2	-2.7	-1.0	-0.2	-0.6	-1.8	1.1	0.1	-2.0	-0.5	-1.1
Alcohol drinker status: Previous	0.3	0.3	2.3	1.5	-0.1	-0.3	-0.1	0.6	-0.6	0.1	-0.4	0.2	0.6	0.3	-0.2
Pack years of smoking	0.8	1.2	4.8	0.0	-1.0	-2.2	-0.9	-0.4	-0.2	-1.9	-1.2	-0.0	-0.1	-0.3	-1.6
Impedance of whole body	0.4	1.9	4.8	2.1	-1.2	-0.9	-1.3	-1.3	0.3	-1.7	-0.2	-2.1	-0.3	-2.2	-1.0
Leg fat mass (left)	2.6	10.1	17.1	-3.7	-4.1	-4.0	-4.1	-3.8	-1.4	-1.8	-0.4	-3.0	-3.5	-3.0	-3.0
Arm predicted mass (left)	0.7	3.3	16.1	-4.0	-2.1	-0.6	-2.0	-2.1	-0.5	-0.6	-1.3	-1.5	-2.1	-0.9	-0.8