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chr14:102,544,860-106,199,579

Best TWAS P=1.13e-23 · Best GWAS P=3.02e-18 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADSSL1	0.05	0.01	bslmm	367	0.01	5.5e-03	-3.4	6.0	2.0e-09	0.00	0.18	0.03	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EIF5	0.07	0.04	lasso	7	0.03	9.7e-05	-5.5	6.5	7.1e-11	0.30	0.94	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NUDT14	0.25	0.26	enet	14	0.27	1.4e-32	7.5	-6.9	7.0e-12	0.04	0.00	1.00	TRUE
4	CommonMind	Brain Pre-frontal Cortex	PPP1R13B	0.04	0.02	enet	14	0.02	1.3e-03	5.8	-6.6	4.7e-11	-0.31	0.42	0.03	TRUE
5	GTEx	Adipose Subcutaneous	KLC1	0.05	0.03	lasso	3	0.03	1.8e-03	5.7	5.1	3.1e-07	0.72	0.15	0.49	FALSE
6	GTEx	Adipose Subcutaneous	XRCC3	0.09	0.08	lasso	5	0.07	3.8e-06	6.0	6.3	3.8e-10	0.60	0.92	0.08	TRUE
7	GTEx	Adipose Subcutaneous	BTBD6	0.08	0.05	lasso	6	0.05	7.0e-05	5.2	-6.5	7.2e-11	-0.04	0.60	0.05	TRUE
8	GTEx	Adipose Subcutaneous	APOPT1	0.06	0.02	lasso	5	0.02	8.2e-03	4.9	-6.2	7.6e-10	-0.59	0.20	0.55	FALSE
9	GTEx	Adipose Subcutaneous	RP11-73M18.8	0.14	0.19	lasso	4	0.20	6.4e-16	4.9	5.4	6.7e-08	0.46	1.00	0.00	FALSE
10	GTEx	Artery Aorta	NUDT14	0.19	0.13	lasso	6	0.09	9.8e-06	5.7	-6.2	5.8e-10	0.03	0.03	0.97	FALSE
11	GTEx	Artery Aorta	BRF1	0.08	0.07	lasso	3	0.07	9.3e-05	5.2	5.4	8.1e-08	0.03	0.35	0.04	FALSE
12	GTEx	Artery Tibial	XRCC3	0.06	0.08	lasso	3	0.03	1.4e-03	4.1	5.5	3.3e-08	0.60	0.37	0.60	FALSE
13	GTEx	Artery Tibial	NUDT14	0.23	0.10	enet	17	0.10	2.6e-08	5.7	-8.6	8.7e-18	0.02	0.01	0.99	TRUE
14	GTEx	Artery Tibial	BTBD6	0.19	0.12	enet	19	0.15	9.1e-12	6.0	-5.7	9.9e-09	-0.03	1.00	0.00	TRUE
15	GTEx	Artery Tibial	RP11-73M18.6	0.05	0.03	lasso	2	0.02	4.7e-03	4.9	5.4	5.8e-08	0.47	0.22	0.17	FALSE
16	GTEx	Brain Caudate basal ganglia	NUDT14	0.55	0.31	lasso	7	0.30	2.2e-09	7.0	-6.4	1.8e-10	0.02	0.00	1.00	FALSE
17	GTEx	Brain Cortex	XRCC3	0.12	0.02	lasso	4	0.01	1.7e-01	4.1	7.5	7.5e-14	0.72	0.05	0.76	FALSE
18	GTEx	Brain Cortex	NUDT14	0.36	0.30	lasso	8	0.26	8.8e-08	7.5	-7.0	2.6e-12	0.05	0.00	1.00	FALSE
19	GTEx	Brain Cortex	RP11-73M18.8	0.35	0.13	enet	34	0.25	1.2e-07	6.0	8.6	9.6e-18	0.39	0.57	0.35	FALSE
20	GTEx	Brain Frontal Cortex BA9	NUDT14	0.29	0.23	lasso	4	0.19	8.0e-06	7.0	-7.5	6.6e-14	0.04	0.00	0.99	FALSE
21	GTEx	Brain Frontal Cortex BA9	APOPT1	0.17	0.07	lasso	3	0.08	4.6e-03	8.7	-7.0	2.7e-12	-0.94	0.02	0.87	FALSE
22	GTEx	Brain Hippocampus	NUDT14	0.56	0.25	lasso	9	0.24	2.7e-06	7.0	-7.2	6.4e-13	0.05	0.00	0.98	FALSE
23	GTEx	Brain Hypothalamus	RPS20P33	0.23	0.11	lasso	4	0.07	8.6e-03	5.3	-5.3	9.0e-08	-0.04	0.05	0.05	FALSE
24	GTEx	Brain Nucleus accumbens basal ganglia	TDRD9	0.23	0.02	lasso	3	0.05	1.5e-02	4.0	-5.8	7.7e-09	-0.37	0.09	0.08	FALSE
25	GTEx	Brain Nucleus accumbens basal ganglia	NUDT14	0.33	0.33	enet	8	0.33	1.6e-09	7.0	-5.9	2.8e-09	0.01	0.00	1.00	FALSE
26	GTEx	Brain Nucleus accumbens basal ganglia	RP11-73M18.8	0.12	0.03	lasso	4	0.01	1.4e-01	-4.3	8.2	1.7e-16	0.51	0.06	0.27	TRUE
27	GTEx	Brain Putamen basal ganglia	NUDT14	0.38	0.20	lasso	5	0.21	8.5e-06	7.5	-7.2	4.7e-13	0.03	0.00	0.99	FALSE
28	GTEx	Breast Mammary Tissue	KLC1	0.12	0.02	enet	26	0.07	2.9e-04	4.0	6.0	2.2e-09	0.66	0.29	0.68	FALSE
29	GTEx	Breast Mammary Tissue	BTBD6	0.11	0.14	lasso	3	0.12	7.9e-07	5.2	-5.2	1.7e-07	-0.03	0.91	0.02	FALSE
30	GTEx	Breast Mammary Tissue	RP11-73M18.8	0.19	0.14	enet	21	0.26	2.0e-13	5.7	5.6	2.5e-08	0.44	1.00	0.00	FALSE
31	GTEx	Breast Mammary Tissue (Male)	RP11-73M18.8	0.22	0.12	lasso	4	0.08	7.3e-03	5.2	5.6	1.9e-08	0.43	0.32	0.07	TRUE
32	GTEx	Breast Mammary Tissue (Female)	KLC1	0.09	0.00	lasso	2	0.00	2.4e-01	5.7	5.5	3.5e-08	0.57	0.08	0.19	FALSE
33	GTEx	Breast Mammary Tissue (Female)	RP11-73M18.8	0.21	0.09	enet	12	0.16	1.3e-05	-7.6	5.7	1.5e-08	0.35	0.57	0.03	FALSE
34	GTEx	Cells EBV-transformed lymphocytes	PPP1R13B	0.15	0.08	lasso	4	0.07	2.2e-03	4.1	-5.4	6.0e-08	-0.45	0.43	0.04	FALSE
35	GTEx	Cells Transformed fibroblasts	NUDT14	0.11	0.04	enet	6	0.05	1.8e-04	5.7	-7.0	2.4e-12	0.04	0.01	0.99	FALSE
36	GTEx	Colon Transverse	ZFYVE21	0.12	0.00	lasso	4	0.00	4.7e-01	3.0	5.3	1.3e-07	0.37	0.12	0.19	FALSE
37	GTEx	Colon Transverse	KLC1	0.16	0.01	lasso	7	0.00	1.9e-01	5.7	5.4	5.2e-08	0.69	0.08	0.49	TRUE
38	GTEx	Colon Transverse	XRCC3	0.13	0.14	lasso	4	0.11	1.0e-05	5.3	5.1	2.8e-07	0.47	0.93	0.01	FALSE
39	GTEx	Colon Transverse	BAG5	0.14	0.05	lasso	10	0.02	4.8e-02	6.3	5.7	9.8e-09	0.57	0.20	0.39	FALSE
40	GTEx	Colon Transverse	NUDT14	0.25	0.07	enet	17	0.08	1.2e-04	5.7	-5.2	1.6e-07	0.04	0.03	0.95	FALSE
41	GTEx	Colon Transverse	RP11-73M18.8	0.26	0.04	enet	23	0.06	8.4e-04	-3.5	5.7	9.3e-09	0.28	0.81	0.02	TRUE
42	GTEx	Esophagus Mucosa	MARK3	0.11	0.03	lasso	4	0.04	1.5e-03	-8.3	-10.0	1.1e-23	-0.77	0.02	0.92	TRUE
43	GTEx	Esophagus Mucosa	XRCC3	0.12	0.15	lasso	2	0.13	4.4e-09	5.2	5.2	1.5e-07	0.49	1.00	0.00	TRUE
44	GTEx	Esophagus Mucosa	NUDT14	0.21	0.21	lasso	2	0.18	2.2e-12	7.5	-7.5	5.6e-14	0.04	0.00	1.00	FALSE
45	GTEx	Esophagus Mucosa	BRF1	0.15	0.10	lasso	3	0.11	4.8e-08	5.2	5.3	1.0e-07	0.03	1.00	0.00	FALSE
46	GTEx	Esophagus Mucosa	RP11-73M18.8	0.11	0.06	lasso	12	0.10	2.1e-07	5.4	5.3	9.7e-08	0.30	0.97	0.00	FALSE
47	GTEx	Esophagus Muscularis	APOPT1	0.16	0.02	enet	11	0.04	2.2e-03	-7.6	-7.5	8.6e-14	-0.53	0.06	0.77	FALSE
48	GTEx	Heart Left Ventricle	NUDT14	0.20	0.14	lasso	6	0.12	8.2e-07	7.0	-7.0	3.2e-12	0.03	0.01	0.99	FALSE
49	GTEx	Heart Left Ventricle	BTBD6	0.13	0.02	enet	12	0.07	1.7e-04	4.9	-6.5	7.9e-11	-0.03	0.24	0.03	FALSE
50	GTEx	Nerve Tibial	TRMT61A	0.10	0.00	lasso	5	0.01	1.0e-01	-4.1	6.3	3.8e-10	0.27	0.22	0.47	FALSE
51	GTEx	Nerve Tibial	NUDT14	0.13	0.10	enet	6	0.10	8.6e-08	5.7	-7.0	3.3e-12	0.03	0.02	0.98	FALSE
52	GTEx	Nerve Tibial	BTBD6	0.08	0.02	lasso	3	0.01	1.1e-01	5.2	-5.1	3.1e-07	-0.02	0.06	0.05	FALSE
53	GTEx	Nerve Tibial	APOPT1	0.10	0.08	lasso	5	0.06	7.8e-05	5.7	-5.5	3.4e-08	-0.60	0.62	0.24	FALSE
54	GTEx	Ovary	RP11-73M18.8	0.19	0.20	lasso	5	0.14	2.4e-04	4.9	5.2	1.7e-07	0.41	0.23	0.06	FALSE
55	GTEx	Pancreas	NUDT14	0.21	0.18	enet	8	0.24	2.1e-10	7.5	-6.9	7.3e-12	0.06	0.00	1.00	FALSE
56	GTEx	Pancreas	JAG2	0.19	0.22	lasso	2	0.19	2.6e-08	7.5	-7.5	8.7e-14	0.04	0.00	1.00	FALSE
57	GTEx	Pancreas	RP11-44N21.4	0.17	0.16	lasso	3	0.13	5.0e-06	7.5	-7.2	6.7e-13	0.05	0.00	0.99	FALSE
58	GTEx	Prostate	TDRD9	0.27	0.14	lasso	10	0.13	4.8e-04	-4.4	-5.7	1.2e-08	-0.22	0.06	0.37	FALSE
59	GTEx	Prostate	RP11-73M18.8	0.15	0.29	lasso	1	0.25	5.2e-07	5.2	5.2	1.6e-07	0.49	0.40	0.11	FALSE
60	GTEx	Skin Not Sun Exposed Suprapubic	RP11-73M18.8	0.10	0.01	lasso	6	0.02	3.8e-02	8.0	7.3	4.1e-13	0.59	0.12	0.60	FALSE
61	GTEx	Skin Sun Exposed Lower leg	TDRD9	0.11	0.03	enet	26	0.03	1.6e-03	-4.4	-5.3	1.1e-07	-0.15	0.86	0.02	FALSE
62	GTEx	Skin Sun Exposed Lower leg	NUDT14	0.15	0.05	enet	11	0.04	2.3e-04	7.0	-6.5	7.2e-11	0.04	0.00	1.00	FALSE
63	GTEx	Skin Sun Exposed Lower leg	BRF1	0.12	0.07	lasso	4	0.07	2.8e-06	5.0	5.4	5.6e-08	0.03	0.97	0.00	FALSE
64	GTEx	Skin Sun Exposed Lower leg	AHNAK2	0.07	0.02	enet	11	0.02	5.4e-03	-2.2	5.2	2.5e-07	-0.02	0.14	0.71	FALSE
65	GTEx	Small Intestine Terminal Ileum	ZFYVE21	0.16	0.10	lasso	2	0.13	7.7e-04	5.7	5.1	2.6e-07	0.34	0.12	0.06	FALSE
66	GTEx	Spleen	KLC1	0.15	0.05	lasso	3	0.03	6.4e-02	8.7	8.5	2.4e-17	0.92	0.03	0.69	FALSE
67	GTEx	Spleen	XRCC3	0.28	0.19	lasso	3	0.24	8.7e-07	5.2	5.4	6.8e-08	0.40	0.72	0.04	FALSE
68	GTEx	Stomach	NUDT14	0.21	0.14	enet	10	0.09	3.9e-05	7.0	-7.1	1.0e-12	0.02	0.01	0.98	FALSE
69	GTEx	Testis	NUDT14	0.44	0.41	lasso	2	0.41	1.4e-19	7.4	-7.4	1.6e-13	0.04	0.00	1.00	FALSE
70	GTEx	Testis	BTBD6	0.12	0.07	lasso	3	0.06	9.6e-04	5.3	-5.2	2.2e-07	-0.03	0.56	0.04	FALSE
71	GTEx	Testis	RP11-73M18.8	0.16	0.12	lasso	4	0.12	4.0e-06	5.2	5.4	8.4e-08	0.44	0.82	0.03	FALSE
72	GTEx	Thyroid	TRAF3	0.10	0.00	enet	20	0.05	1.4e-04	-4.8	6.9	5.5e-12	0.23	0.17	0.14	FALSE
73	GTEx	Thyroid	TRMT61A	0.11	0.03	lasso	4	0.02	1.2e-02	-8.4	9.0	3.0e-19	0.48	0.12	0.81	FALSE
74	GTEx	Thyroid	BRF1	0.21	0.09	enet	24	0.14	1.6e-10	-5.0	5.8	4.9e-09	0.07	1.00	0.00	FALSE
75	GTEx	Thyroid	APOPT1	0.11	0.12	lasso	1	0.10	1.9e-08	6.0	-6.0	2.1e-09	-0.64	1.00	0.00	FALSE
76	GTEx	Thyroid	RP11-45P15.4	0.09	0.08	lasso	3	0.08	1.8e-06	-5.5	-5.2	2.5e-07	-0.30	0.90	0.00	FALSE
77	GTEx	Whole Blood	KLC1	0.16	0.13	lasso	3	0.11	3.6e-10	5.2	5.6	1.9e-08	0.51	1.00	0.00	FALSE
78	GTEx	Whole Blood	RP11-73M18.8	0.13	0.10	lasso	5	0.14	1.4e-12	5.2	5.2	1.9e-07	0.30	1.00	0.00	FALSE
79	GTEx	Whole Blood	RP11-73M18.6	0.04	0.00	enet	20	0.00	5.1e-01	-3.6	5.2	1.8e-07	0.26	0.08	0.14	FALSE
80	METSIM	Adipose	BAG5	0.06	0.07	lasso	3	0.07	4.5e-10	-4.3	5.2	2.5e-07	0.19	1.00	0.00	FALSE
81	METSIM	Adipose	TDRD9	0.08	0.04	lasso	10	0.06	1.9e-09	5.7	-7.4	1.7e-13	-0.55	0.46	0.53	FALSE
82	METSIM	Adipose	TRAF3	0.04	0.02	enet	7	0.04	4.5e-06	4.5	5.4	7.3e-08	-0.03	0.84	0.00	TRUE
83	NTR	Blood	KLC1	0.04	0.02	blup	393	0.04	8.2e-12	5.2	6.2	6.5e-10	0.53	0.99	0.01	FALSE
84	YFS	Blood	BAG5	0.01	0.01	bslmm	350	0.00	1.9e-02	5.7	6.9	4.7e-12	0.41	0.18	0.05	FALSE
85	YFS	Blood	CKB	0.03	0.02	lasso	4	0.02	6.6e-07	-7.6	8.2	2.5e-16	0.39	0.93	0.06	FALSE
86	YFS	Blood	EIF5	0.11	0.09	enet	29	0.10	1.5e-29	-5.5	-6.9	5.2e-12	-0.28	1.00	0.00	FALSE
87	YFS	Blood	MARK3	0.04	0.04	lasso	3	0.04	1.6e-12	-7.7	-7.4	1.1e-13	-0.37	0.96	0.04	FALSE
88	YFS	Blood	TRMT61A	0.08	0.11	lasso	4	0.12	1.6e-37	8.0	8.6	7.5e-18	0.70	0.77	0.23	FALSE
89	YFS	Blood	ZFYVE21	0.01	0.00	blup	339	0.00	8.9e-03	-7.1	7.6	2.1e-14	0.40	0.17	0.42	FALSE
90	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NUDT14	0.04	0.03	lasso	2	0.03	2.7e-03	5.7	-6.1	1.2e-09	0.03	0.03	0.80	FALSE
91	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUDT14	0.04	0.04	lasso	3	0.04	9.2e-09	7.0	-7.0	2.6e-12	0.04	0.01	0.99	FALSE
92	The Cancer Genome Atlas	Colon Adenocarcinoma	NUDT14	0.06	0.03	lasso	3	0.03	6.8e-03	7.4	-5.4	7.3e-08	0.03	0.00	0.80	FALSE
93	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUDT14	0.06	0.02	enet	8	0.06	3.2e-07	7.5	-6.0	1.8e-09	0.06	0.01	0.99	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XRCC3	0.03	0.04	enet	3	0.04	6.1e-05	5.2	5.2	1.9e-07	0.49	0.36	0.54	FALSE
95	The Cancer Genome Atlas	Brain Lower Grade Glioma	BTBD6	0.02	0.03	lasso	2	0.02	9.2e-04	5.2	5.2	2.0e-07	0.02	0.02	0.96	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	5.7	-5.5	3.7e-08	-0.71	0.07	0.37	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	NUDT14	0.10	0.10	lasso	5	0.11	1.3e-12	6.0	-6.9	6.2e-12	0.03	0.06	0.94	FALSE
98	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	BTBD6	0.10	0.01	blup	37	0.03	1.3e-02	4.9	6.1	8.1e-10	0.02	0.01	0.50	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKB	0.07	0.09	blup	32	0.10	1.1e-10	8.7	-8.0	1.1e-15	-0.91	0.01	0.99	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUDT14	0.10	0.13	lasso	4	0.13	1.5e-13	7.0	-7.0	3.0e-12	0.04	0.01	0.99	FALSE
101	The Cancer Genome Atlas	Rectum Adenocarcinoma	BRF1	0.18	0.20	lasso	2	0.13	6.1e-04	5.3	5.3	1.5e-07	0.04	0.12	0.06	FALSE
102	The Cancer Genome Atlas	Rectum Adenocarcinoma	BTBD6	0.17	0.17	lasso	3	0.11	1.5e-03	5.3	5.2	1.7e-07	0.04	0.02	0.87	FALSE
103	The Cancer Genome Atlas	Soft Tissue Sarcoma	NUDT14	0.05	0.02	blup	39	0.04	2.1e-03	7.5	-8.3	1.0e-16	0.00	0.01	0.77	FALSE
104	The Cancer Genome Atlas	Stomach Adenocarcinoma	BTBD6	0.04	0.00	blup	38	0.03	1.7e-03	6.0	6.8	1.5e-11	0.06	0.01	0.60	TRUE
105	The Cancer Genome Atlas	Stomach Adenocarcinoma	C14orf153	0.20	0.05	lasso	2	0.04	8.8e-04	8.7	-7.4	1.1e-13	-0.97	0.00	0.98	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	BRF1	0.06	0.02	blup	47	0.07	2.0e-07	-5.1	7.4	1.5e-13	0.03	0.95	0.02	TRUE
107	The Cancer Genome Atlas	Thyroid Carcinoma	BTBD6	0.15	0.10	lasso	9	0.14	3.3e-13	5.1	6.3	2.3e-10	0.02	0.07	0.93	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	KLC1	0.04	0.01	blup	82	0.03	5.4e-04	5.7	5.9	2.7e-09	0.65	0.04	0.74	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	PPP1R13B	0.04	0.04	lasso	2	0.03	7.9e-04	5.4	5.3	1.2e-07	0.44	0.19	0.48	FALSE