Hub : Genes

CDAN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0430	0.0220	1.6e-03	0.015	0.023	0.002	0.022	0.011	4.9e-03	0.00079	1.8e-01	0.00088	1.5e-02
2	GTEx	Artery Aorta	0.0910	0.0410	2.0e-04	0.078	NA	0.075	NA	0.072	4.4e-05	NA	6.3e-05	NA	8.5e-05
3	GTEx	Brain Cerebellar Hemisphere	0.4370	0.1110	5.4e-05	-0.009	NA	0.011	NA	0.009	6.5e-01	NA	1.6e-01	NA	1.8e-01
4	GTEx	Brain Cerebellum	0.2370	0.0910	8.4e-05	0.049	NA	0.024	NA	0.068	1.5e-02	NA	6.5e-02	NA	4.6e-03
5	GTEx	Brain Cortex	0.1040	0.0530	3.5e-03	0.024	NA	0.037	NA	0.055	7.1e-02	NA	3.5e-02	NA	1.2e-02
6	GTEx	Nerve Tibial	0.1908	0.0556	6.2e-09	0.179	NA	0.137	NA	0.149	9.5e-13	NA	6.7e-10	NA	9.7e-11
7	GTEx	Testis	0.1510	0.0580	6.8e-06	0.159	NA	0.106	NA	0.137	1.5e-07	NA	2.0e-05	NA	1.1e-06
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0513	0.0315	6.8e-04	0.023	0.028	0.010	NA	0.018	1.0e-03	0.00036	2.6e-02	NA	3.9e-03
9	TCGA	Liver Hepatocellular Carcinoma	0.1300	0.1250	4.2e-03	0.037	0.054	0.036	NA	0.032	7.2e-03	0.00140	7.9e-03	NA	1.2e-02
10	TCGA	Stomach Adenocarcinoma	0.0710	0.0510	9.2e-03	0.026	0.007	0.031	NA	0.028	5.6e-03	0.09000	2.7e-03	NA	3.9e-03
11	TCGA	Thyroid Carcinoma	0.0380	0.0250	2.1e-03	0.003	0.027	0.013	NA	0.010	1.5e-01	0.00100	1.6e-02	NA	3.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	3.8	5.9	10.4	2.6	2.2	0.8	2.6	3.2	2.9	2.9	-2.8	-2.6	-1.2	-1.8
Bipolar Disorder or Schizophrenia	2.2	5.3	10.5	1.2	2.5	1.0	3.2	3.1	2.8	2.1	-2.4	-2.4	-0.6	-2.2
Depressed Affect (Nagel 2018)	2.7	5.7	13.2	-3.6	-2.0	-1.2	-1.5	-2.6	-2.6	-3.2	3.0	2.6	1.2	1.3
Depression (Nagel 2018)	0.9	1.4	5.2	0.2	2.3	1.5	0.9	1.1	1.4	0.9	-0.8	-1.4	0.5	-0.7
Intelligence (Savage-Jansen 2018)	0.6	1.8	7.3	1.6	0.6	-0.9	-0.8	0.6	0.1	1.0	0.9	-1.0	-2.7	-2.3
Neuroticism (Nagel 2018)	3.4	8.0	14.1	-3.7	-2.7	-1.9	-2.5	-3.2	-3.1	-3.8	2.9	3.2	1.7	1.6
Schizophrenia (2018)	0.7	1.4	4.3	-0.6	1.5	0.8	2.1	1.4	1.4	0.4	-0.7	-1.1	0.0	-1.4
Schizophrenia vs Biploar Disorder	3.2	4.2	7.7	-2.8	-2.5	-0.9	-1.6	-2.1	-1.9	-2.6	2.4	2.5	0.6	1.3
Worry (Nagel 2018)	2.7	5.8	10.1	-3.0	-2.4	-1.1	-1.8	-2.7	-2.9	-3.2	3.0	2.8	0.4	1.1
Alzheimer’s Disease (in mother)	1.0	1.1	3.3	-1.8	-0.9	0.8	0.1	-1.2	-1.1	-0.6	0.9	1.3	0.4	1.4
Alzheimer’s Disease (in father)	0.9	1.0	3.1	1.8	0.8	1.6	-0.1	0.7	0.9	1.2	-1.2	-0.7	-0.3	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	2.1	-0.4	-0.4	1.5	-0.2	-0.9	-0.3	-0.0	0.3	0.7	0.3	0.9
Crohns Disease (2017)	0.2	0.4	2.9	-0.6	0.1	-0.1	-0.8	-0.5	-0.5	-0.4	0.1	0.3	1.7	0.2
Irritable Bowel Disease (IBD)	0.4	0.9	2.4	-0.7	-0.4	-1.0	-1.5	-0.9	-0.7	-1.5	-0.0	0.8	1.0	0.5
Ulcerative Colitis (UC)	0.3	0.6	2.3	-0.3	-0.3	-1.1	-1.3	-0.6	-0.1	-1.5	-0.6	0.4	0.2	0.4
Major Depression (MDD)	0.3	0.4	1.3	-0.3	1.1	0.1	0.0	0.3	0.8	-0.1	0.1	-0.7	-0.5	-1.1
Reaction Time	2.4	4.6	9.4	-2.2	-2.2	-1.4	-1.4	-2.6	-2.4	-3.0	3.1	2.4	-0.9	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.7	0.7	0.2	-0.9	-0.9	0.0	-0.6	0.1	1.3	-0.2	-0.9	-1.1
Breast Cancer	0.2	0.4	2.3	0.1	-1.5	0.6	0.3	-0.2	-0.4	-0.2	0.1	0.7	-1.2	0.4
Ovarian Cancer	0.2	0.2	0.8	0.3	-0.9	0.7	-0.3	0.3	-0.3	-0.0	-0.5	0.3	0.4	0.7
Prostate Cancer	0.4	0.5	3.6	-1.9	-0.4	-0.6	-0.0	-0.3	-0.2	-0.5	1.0	0.5	0.5	-0.1
Age at First Birth	0.8	1.1	5.6	1.1	0.2	0.9	0.9	0.8	0.1	1.2	-0.1	-0.3	-2.4	-1.2
Bipolar Disorder (2011)	10.6	10.3	17.2	3.9	3.6	1.6	3.2	3.9	3.3	4.2	-2.9	-3.3	-2.0	-2.2
Body Mass Index (BMI) (2010)	1.9	2.6	6.5	0.7	2.0	1.8	1.1	1.5	2.6	1.3	-1.7	-2.1	0.3	-1.6
Coronary Artery Disease (CAD)	0.2	0.2	1.1	-0.0	-0.0	-0.3	1.1	0.6	0.6	0.1	-0.1	-0.4	-0.3	0.3
Crohns Disease (2012)	0.1	0.2	0.6	-0.0	-0.3	0.4	0.1	0.5	0.1	0.4	0.4	-0.2	0.8	-0.5
Mean Putamen Volume	0.5	0.5	1.5	0.6	-0.4	0.4	-0.8	-0.5	-0.4	0.3	-0.8	0.6	1.2	1.2
Fasting Glucose	0.6	0.7	2.1	0.1	0.0	0.9	1.4	0.9	1.4	0.1	-1.4	-0.4	0.6	0.3
HbA1C	1.7	1.8	3.1	0.8	1.4	1.4	1.8	1.4	1.7	1.4	-1.3	-1.7	-1.0	-0.3
HDL Cholesterol	0.3	0.6	1.5	0.7	-1.1	-0.4	-0.6	-0.9	-0.8	-0.6	-0.4	0.9	-0.2	1.2
LDL Cholesterol	0.1	0.2	0.4	0.5	0.1	0.5	0.6	0.4	0.4	0.2	-0.4	-0.6	-0.2	-0.5
Lupus	0.3	0.4	1.5	0.8	-0.0	-1.2	0.2	0.8	0.2	0.7	-0.1	-0.1	-1.0	-0.5
Neuroticism (2016)	2.5	3.5	6.0	-2.0	-2.4	-1.5	-1.9	-1.6	-1.6	-2.4	1.0	2.2	1.7	1.9
Primary Biliary Cirrhosis	0.8	1.1	2.3	1.1	1.2	0.9	1.2	1.2	1.1	1.5	-0.8	-1.1	-0.1	-0.6
Rheumatoid Arthritis	0.1	0.2	0.7	-0.5	-0.4	-0.3	-0.3	-0.1	-0.3	-0.5	0.2	0.3	0.9	0.7
Schizophrenia (2014)	0.6	1.4	4.2	-0.4	1.3	0.3	2.0	1.6	1.4	0.4	-0.9	-1.1	0.2	-1.7
Triglycerides	0.2	0.3	0.9	-0.6	0.8	0.9	0.4	0.4	0.6	-0.0	-0.4	-0.4	0.8	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.6	-0.3	-0.0	-0.2	0.1	0.1	0.9	0.1	0.9	-0.2	-1.0	-1.3
Ulcerative Colitis	0.2	0.3	1.2	-0.7	-0.6	-0.8	-0.0	0.2	0.0	-1.1	-0.2	0.4	-0.1	-0.0
Blood Eosinophil Count	0.1	0.8	2.1	-1.0	-1.0	1.1	-0.2	-1.2	-0.9	-0.4	1.4	0.9	-0.3	0.3
Blood Platelet Count	1.1	13.0	25.3	-4.3	-3.6	-2.5	-2.5	-2.9	-5.0	-3.8	4.9	4.7	-0.5	2.1
Blood Red Count	0.3	2.8	16.8	0.4	0.4	-0.7	-4.1	-2.5	-0.8	-1.0	-0.5	-0.1	2.2	0.2
Blood White Count	2.0	14.5	29.1	-5.4	-3.6	-2.9	-2.4	-4.1	-4.5	-4.6	5.0	4.1	0.9	1.5
Heel T-Score	0.4	3.2	5.5	2.3	1.3	2.1	0.7	1.9	1.9	2.0	-2.1	-1.9	-1.4	-1.3
BMI	0.2	1.4	4.5	0.1	1.2	2.1	1.5	0.3	1.2	0.4	-1.6	-1.3	1.3	-0.3
Height	0.2	4.2	20.0	4.5	-1.0	-0.4	-2.2	0.5	0.9	1.2	-3.3	-0.0	-2.6	0.8
Waist Hip Ratio (WHR)	0.1	0.5	1.8	-1.1	-0.2	0.3	-1.2	-0.7	-0.2	-1.0	0.0	0.2	1.3	0.3
Systolic Blood Pressure	0.1	0.6	1.5	-0.7	-0.9	-0.7	0.1	-0.1	-0.8	-0.4	1.2	0.7	-1.2	-0.3
Smoking Status	0.3	0.7	4.1	-0.4	0.3	0.5	2.0	1.0	0.9	0.1	-0.5	-0.5	0.8	0.4
Allergy or Eczema	0.1	0.2	0.7	0.1	-0.2	-0.7	-0.9	-0.3	0.4	-0.5	-0.4	0.1	0.9	-0.1
Cardiovascular Disease	1.7	5.6	10.6	-3.3	-1.8	-1.0	-1.5	-2.8	-3.2	-2.5	2.2	2.8	1.9	1.9
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.4	0.5	-0.1	-0.4	-0.2	-0.4	0.1	0.3	-0.2	0.5	0.3
Respiratory disease	0.2	0.4	2.0	-0.6	-0.3	1.4	0.8	0.8	0.8	-0.1	-0.2	0.1	-0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.6	-0.4	-0.1	0.2	1.3	0.6	0.8	-0.0	-0.2	0.0	-0.7	-0.5
Lung FEV1/FVC ratio	0.5	2.4	4.9	2.2	1.9	0.2	0.6	1.8	1.5	1.6	-1.8	-2.0	-0.5	-1.4
Lung FVC	1.0	4.9	8.9	2.8	3.0	0.2	0.9	2.4	2.7	2.6	-1.9	-2.8	-0.9	-2.1
Neuroticism	2.6	6.2	10.6	-3.3	-2.7	-1.2	-2.0	-2.6	-2.8	-3.1	3.1	3.0	0.3	1.2
Chronotype (morning person)	0.7	1.5	3.9	-0.2	-1.1	-1.1	-2.0	-1.2	-1.6	-1.0	0.2	1.5	-0.1	1.7
Hair Pigment	0.0	0.3	1.3	-0.2	0.9	-1.1	0.1	0.5	-0.0	0.5	-0.2	-0.6	-0.1	-0.3
Tanning	0.3	3.6	7.4	1.6	2.7	1.2	1.8	1.6	1.6	2.5	-0.4	-2.6	-1.7	-2.1
Hand grip strength (left)	0.5	1.4	8.3	0.1	0.6	0.2	-1.1	-0.4	0.2	-0.2	-1.6	0.2	2.9	1.7
Number of treatments/medications taken	0.6	1.0	4.0	-0.4	-0.3	2.0	0.1	0.1	-0.2	-0.4	-1.4	0.2	1.8	1.1
Average weekly spirits intake	0.1	0.1	0.6	-0.1	0.4	0.2	-0.1	-0.2	0.4	0.1	-0.8	-0.4	-0.1	-0.2
Sensitivity / hurt feelings	1.5	2.6	5.1	-2.1	-1.0	-1.3	-1.9	-1.7	-1.1	-2.3	0.9	1.5	1.9	1.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.0	-0.2	1.4	0.3	0.2	0.6	0.6	0.3	-0.2	-0.6	0.9	-0.7
Hearing difficulty/problems: Yes	0.9	1.4	4.3	0.2	2.1	0.8	1.0	1.1	1.1	1.2	-1.1	-1.4	1.2	-0.5
Relative age of first facial hair	0.5	1.0	3.8	-1.6	0.0	-0.5	-1.1	-0.3	-0.3	-1.4	0.1	0.4	1.9	0.8
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.2	0.6	1.9	2.0	0.7	0.8	1.2	0.8	-2.0	-1.4	1.3	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.0	-1.0	-0.1	0.2	0.3	-0.4	0.0	-0.4	0.4	0.0	0.9	0.1
Ever had hysterectomy (womb removed)	2.1	2.4	6.7	0.4	1.1	2.6	2.6	1.5	1.7	1.6	-0.8	-1.3	-0.8	-0.7
Systolic blood pressure, automated reading	0.2	0.6	1.3	-0.6	-1.1	0.2	0.7	-0.2	-1.0	-0.3	0.9	0.9	-1.1	0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.7	1.3	-1.3	0.1	-0.6	-0.2	-0.2	-0.0	-0.9	0.9	0.2	1.0
Angina	2.0	2.6	4.5	-1.9	-1.7	0.6	-1.1	-1.8	-2.1	-1.9	1.6	2.1	0.7	1.4
Medication for hormone replacement therapy	0.4	0.5	1.4	1.1	0.2	-0.0	0.4	0.8	1.2	0.3	-0.7	-0.5	-0.7	-0.5
Vitamin and mineral supplements	0.2	0.3	1.2	-0.4	0.5	-0.6	0.1	0.2	1.1	0.1	-0.0	-0.7	0.2	-0.8
Supplements: Zinc	2.4	2.6	6.3	-1.6	-1.0	-1.6	-1.6	-1.9	-2.5	-2.1	1.9	1.5	-0.3	0.2
Medication: Co-codamol	1.2	1.4	2.8	1.5	1.7	1.1	0.5	0.9	1.0	1.5	-1.5	-1.2	1.1	0.1
Medication: Metformin	1.2	1.7	3.9	1.5	0.8	2.0	1.2	1.1	1.7	1.1	-1.8	-1.1	-0.6	-0.7
Diabetes (father)	0.9	1.1	1.8	0.3	1.3	-0.5	1.3	1.3	1.3	1.2	-0.8	-1.2	0.8	-0.6
Diabetes (mother)	0.4	0.5	1.8	-0.8	0.2	-1.3	-0.6	-0.5	-0.2	-0.9	0.6	0.2	1.3	-0.0
Severe depression (siblings)	1.7	1.9	9.8	-0.2	-0.0	-3.1	-0.9	0.1	-0.0	-0.2	1.8	-0.0	-2.1	-1.5
Pack years adult smoking proportion	3.1	4.8	8.1	-2.8	-2.2	-1.2	-1.8	-2.4	-2.2	-2.4	1.9	2.8	1.5	2.2
Impedance of leg (right)	1.4	6.7	19.3	-2.7	-2.7	-2.6	-1.4	-2.2	-3.1	-2.3	4.4	2.9	-1.9	-0.3
Leg fat-free mass (left)	0.9	4.6	18.3	3.0	1.7	1.8	0.5	1.6	2.5	1.7	-4.3	-1.8	1.1	0.9
Trunk fat percentage	0.5	1.8	4.3	-0.5	-2.1	1.1	-0.9	-1.8	-1.3	-1.9	-0.0	1.6	0.6	1.4
Hand grip strength (right)	0.3	0.9	5.1	-0.2	0.6	-0.3	-0.8	-0.3	0.1	-0.3	-1.2	0.2	2.2	1.3
Townsend deprivation index at recruitment	0.6	0.9	1.7	-1.1	-0.5	-0.2	-0.4	-1.3	-1.2	-0.7	1.1	1.3	0.9	0.5
Current tobacco smoking	0.7	1.1	4.0	-1.7	-0.5	-1.3	-0.7	-0.9	-0.6	-1.0	2.0	0.5	0.2	-0.7
Average weekly fortified wine intake	0.4	0.5	1.7	0.2	-1.3	0.5	-0.5	-0.3	-0.6	-0.5	-0.1	1.0	-0.1	1.0
Maternal smoking around birth	1.2	1.7	5.6	-1.9	-0.8	-1.0	-1.0	-1.5	-1.3	-1.3	2.4	1.0	-0.5	-0.3
Fed-up feelings	4.6	8.4	18.8	-4.3	-2.5	-0.1	-1.1	-2.9	-2.8	-3.2	2.4	3.4	3.6	3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.4	-0.5	0.5	1.2	0.7	0.7	0.7	0.0	0.1	-0.4	0.1	-0.4
Relative age voice broke	2.4	3.6	5.6	-2.4	-1.0	-2.3	-2.4	-2.0	-2.2	-2.2	2.3	1.4	0.5	0.6
Taking other prescription medications	0.7	1.1	3.1	-1.4	-0.9	0.8	-0.6	-0.8	-0.6	-1.2	-0.4	0.9	1.8	1.4
Age when periods started (menarche)	0.1	0.3	1.6	0.7	-0.1	-0.5	-1.2	-0.2	-0.1	-0.1	-0.1	0.0	-0.5	-0.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.1	0.9	0.7	1.7	1.2	1.2	1.5	0.8	-2.0	-1.1	1.9	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.3	0.6	1.5	1.5	1.2	1.1	1.2	1.1	-0.6	-1.4	0.1	-1.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	-0.3	0.2	-0.6	0.7	0.4	-0.3	0.3	0.2	0.0	-0.1	0.2
Qualifications: CSEs or equivalent	1.7	2.2	3.9	-1.2	-1.8	-1.6	-1.0	-1.2	-1.7	-1.9	1.5	2.0	-0.2	1.4
Serious illness, injury or assault to yourself	2.0	2.4	9.6	-1.4	-0.7	0.1	-1.1	-1.4	-0.3	-1.7	-0.8	1.1	3.1	2.4
High blood pressure	1.7	4.8	7.9	-2.7	-2.0	-0.8	-1.9	-2.5	-2.8	-2.6	1.7	2.5	1.8	1.9
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.3	0.4	-0.6	-1.5	-1.1	-0.4	0.5	-0.9	-0.0	0.0	-0.4	-0.5
Multivitamins +/- minerals	0.2	0.2	1.4	-0.1	-0.3	0.5	-0.2	-0.2	-1.2	-0.6	0.5	0.4	-0.1	-0.0
Stomach or abdominal pain in last month	2.1	2.6	4.1	-1.6	-1.5	-2.0	-2.0	-2.0	-1.5	-1.8	1.7	1.7	0.7	0.5
Supplements: Glucosamine	2.5	3.2	10.9	1.9	1.2	2.9	0.4	1.0	1.6	1.3	-3.3	-1.3	1.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	0.3	0.9	0.8	0.6	0.4	1.1	0.9	-0.9	-0.9	0.2	-0.0
Medication: Atenolol	0.8	1.0	3.3	-1.5	-0.7	1.2	-0.4	-0.3	-0.7	-1.0	0.1	0.6	1.8	1.0
Medication: Levothyroxine sodium	0.2	0.3	1.2	-0.4	0.1	0.7	-0.2	-0.2	-0.1	0.1	-0.7	0.3	1.1	0.9
Sitting height	0.2	1.4	4.9	1.4	-1.2	-1.6	-2.2	-0.9	-0.2	-0.4	-0.7	1.1	-0.2	1.4
Chronic bronchitis/emphysema (father)	0.9	1.1	3.3	-0.1	1.2	1.8	1.4	0.7	1.0	0.8	-1.0	-0.9	1.1	-0.2
High blood pressure (mother)	0.5	0.7	3.2	-1.0	0.7	-1.3	-0.2	-0.1	-0.4	-0.3	0.8	0.2	1.8	0.6
Body mass index (BMI)	0.3	1.2	4.5	-0.4	-0.2	1.7	0.4	-0.5	0.4	-0.7	-1.5	-0.1	2.1	1.3
Impedance of leg (left)	1.3	6.4	19.7	-2.6	-2.4	-2.3	-1.5	-2.3	-3.1	-2.2	4.4	2.7	-1.7	-0.3
Leg predicted mass (left)	0.8	4.5	17.6	2.9	1.7	1.8	0.5	1.6	2.5	1.8	-4.2	-1.8	1.1	0.8
Trunk fat mass	0.2	0.9	1.8	0.3	-1.1	1.3	-0.5	-1.0	-0.3	-1.1	-1.3	0.7	0.9	1.3
Waist circumference	0.4	1.6	5.1	-0.3	-0.1	2.2	0.3	-0.6	0.4	-0.9	-2.0	-0.1	2.3	1.3
Number of incorrect matches in round	2.4	4.0	6.8	1.1	1.8	2.1	2.5	2.5	2.6	2.2	-2.5	-2.0	0.9	-0.2
Past tobacco smoking	0.7	1.4	3.7	0.6	-0.7	-1.7	-1.9	-0.7	-1.1	-0.1	1.2	0.3	-1.8	-0.8
Alcohol usually taken with meals	0.4	0.6	3.3	-0.6	0.2	0.5	-1.0	-0.7	-0.7	-0.4	-0.5	0.1	1.8	0.7
Nervous feelings	1.0	1.8	3.7	-1.6	-1.6	-0.1	-0.3	-1.3	-1.7	-1.6	1.2	1.9	1.1	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	-1.2	-0.5	-0.7	-0.3	-1.0	-0.7	-1.1	0.8	0.9	0.8	0.4
Hearing difficulty/problems with background noise	1.5	2.4	5.9	0.3	2.4	-1.4	0.5	1.1	2.1	1.1	0.0	-2.3	0.1	-2.4
Hair/balding pattern: Pattern 2	0.9	1.1	3.3	-1.3	-0.9	-1.0	-0.2	-1.0	-1.4	-1.1	1.8	0.9	-0.2	0.3
Had menopause	0.3	0.4	1.7	-0.6	-0.7	1.3	0.9	0.1	-0.0	0.0	-0.1	0.3	0.7	0.4
Had other major operations	0.3	0.4	1.3	0.4	0.4	0.2	-0.0	0.0	0.0	0.5	0.3	-0.8	-1.1	-1.1
Forced vital capacity (FVC)	1.2	4.4	11.0	3.3	2.6	-0.8	0.1	2.1	2.5	2.3	-2.6	-2.4	-0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.1	1.6	1.8	2.0	1.5	1.7	2.0	1.8	-1.4	-2.3	-0.3	-1.4
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	5.9	2.0	2.2	0.8	0.3	1.5	2.0	1.8	-1.5	-2.4	-0.7	-1.6
Qualifications: None of the above	0.2	0.4	1.7	-1.3	-0.5	-0.3	-0.3	-0.6	-0.3	-0.6	1.2	0.1	0.3	-0.4
Financial difficulties in last 2 years	2.1	2.9	5.9	-2.3	-0.9	-1.3	-1.7	-1.8	-1.3	-2.2	1.0	1.4	2.4	1.6
Mouth/teeth dental problems	2.1	3.3	8.8	3.0	1.4	-1.1	-0.0	1.7	1.6	1.8	-1.2	-2.0	-2.3	-2.3
Heart attack	0.3	0.4	0.9	-0.9	-0.1	0.9	-0.7	-0.7	-0.4	-0.8	0.2	0.4	1.0	0.7
Allergy	0.7	1.5	3.8	-1.5	-0.4	-1.3	-0.9	-1.2	-1.9	-0.7	1.5	1.3	0.9	1.1
Pain all over the body in last month	1.5	1.6	10.3	0.2	1.0	3.2	1.7	0.8	0.8	1.0	-0.7	-0.8	-0.2	-0.3
Diabetes (self-reported)	0.3	0.4	1.3	0.7	-0.3	1.1	0.6	0.4	1.0	0.1	-1.0	-0.1	-0.3	0.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.2	0.3	-0.3	-1.2	-1.4	-0.7	-0.8	-0.8	1.4	0.3	-1.5	-1.0
Medication: Ramipril	1.5	1.9	3.7	-1.5	-0.9	-1.0	-1.4	-1.6	-1.9	-1.5	1.0	1.4	1.5	1.1
Medication: Simvastatin	0.4	0.6	3.3	-1.8	-0.3	0.2	-0.2	-0.6	-0.3	-0.8	0.5	0.5	1.4	0.1
Fluid intelligence score	0.5	1.1	3.4	0.5	0.1	-1.8	-1.5	-0.6	-0.4	-0.1	1.8	-0.3	-0.6	-1.3
Illnesses of siblings	3.2	4.5	7.2	2.1	2.6	0.8	2.0	2.4	1.9	2.7	-1.0	-2.4	-1.8	-2.5
Neuroticism score	2.3	4.8	8.2	-2.9	-2.4	-1.2	-2.1	-2.2	-2.1	-2.6	2.5	2.7	1.0	1.5
Weight	0.3	1.5	7.4	1.3	0.3	1.6	0.2	0.2	1.2	0.3	-2.7	-0.7	1.3	1.1
Impedance of arm (right)	0.9	4.0	8.0	-0.4	-2.8	-2.1	-1.9	-1.3	-2.3	-1.6	2.4	2.4	-2.6	-0.0
Arm fat percentage (right)	0.2	0.7	1.4	0.1	-1.2	1.1	-0.2	-0.7	-0.1	-1.1	-1.1	0.6	1.0	1.1
Trunk fat-free mass	1.4	8.0	22.3	3.1	3.2	2.0	1.5	2.6	3.6	3.0	-4.7	-3.0	1.3	0.1
Hip circumference	0.2	0.9	2.8	0.4	-0.7	1.2	0.1	-0.6	0.1	-0.7	-1.7	0.3	1.3	1.5
Time employed in main current job	0.1	0.2	0.4	0.6	0.3	0.3	-0.1	0.1	0.0	-0.1	-0.6	-0.1	0.7	0.6
Alcohol intake versus 10 years previously	1.5	2.3	5.3	-0.9	-1.4	-1.1	-1.5	-1.4	-0.9	-1.8	-0.0	1.5	2.3	2.3
Father’s age at death	3.6	4.8	7.9	2.3	2.6	0.9	1.2	2.6	2.4	2.8	-2.2	-2.8	-1.1	-2.1
Worrier / anxious feelings	2.4	4.6	7.9	-2.4	-2.3	-0.9	-1.6	-2.5	-2.7	-2.5	2.4	2.8	0.3	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.7	-1.3	-0.3	-0.6	-1.1	-1.2	-0.3	-1.3	0.6	0.8	1.6	1.0
Falls in the last year	0.9	1.2	3.3	-1.8	-0.6	-1.6	-0.5	-0.9	-1.2	-0.6	1.6	0.9	0.8	0.5
Hair/balding pattern: Pattern 3	0.7	1.1	2.6	-1.6	-0.9	0.8	-1.1	-1.1	-0.6	-1.4	0.0	1.1	1.1	0.9
Number of live births	3.1	4.4	9.8	1.9	1.5	3.1	2.6	2.2	2.4	1.8	-1.5	-2.5	-0.8	-1.9
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	12.2	3.5	2.5	-0.9	-0.1	2.0	2.3	2.3	-2.5	-2.5	-0.8	-1.4
Pulse rate	0.3	0.4	1.7	0.3	0.9	0.4	-0.2	0.4	0.0	0.5	-1.1	-0.5	1.3	0.2
Happiness	0.2	0.3	0.8	0.5	0.2	0.4	0.3	0.4	0.7	0.0	-0.0	-0.3	-0.8	-0.9
Noisy workplace	0.3	0.4	1.2	0.7	0.5	0.7	0.4	0.4	0.6	0.5	-1.1	0.1	0.2	1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.2	1.1	0.9	-0.9	-0.4	0.4	0.2	0.9	-0.5	-0.9	-0.7	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.0	-0.3	0.3	-0.1	0.3	0.5	0.3	-0.0	-0.2	0.3	-0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	2.8	-0.5	-0.4	1.1	0.1	-0.2	-0.0	-0.4	-0.6	0.6	1.7	1.4
Asthma	2.3	4.6	9.7	1.7	1.2	3.1	2.4	2.6	2.3	2.1	-1.4	-1.9	-2.2	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.9	-0.5	0.8	-1.0	1.0	0.7	0.6	0.6	0.6	-0.9	-1.7	-1.3
Medication: Cholesterol lowering	0.5	0.7	3.1	-1.3	-0.3	0.6	-0.6	-0.8	-0.3	-0.9	-0.2	0.6	1.8	0.8
Depression (self-reported)	1.0	1.2	5.6	-0.4	-0.3	-0.4	-2.4	-1.3	-1.2	-1.1	1.2	0.8	0.2	-0.0
Medication: Lansoprazole	0.6	0.6	2.9	0.3	-0.1	1.7	0.8	0.7	0.8	0.3	-1.0	-0.1	0.9	0.4
Prospective memory result	0.1	0.2	0.6	0.2	0.3	0.6	-0.8	0.0	-0.3	0.1	-0.5	-0.0	0.5	0.2
Lung cancer (father)	1.2	1.4	5.0	-0.0	1.2	1.8	2.2	1.1	1.3	1.2	-0.0	-1.0	-0.5	-0.6
Illnesses of mother	0.5	0.6	2.0	0.7	0.2	0.0	0.8	0.6	0.7	0.6	-0.7	-1.0	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.5	17.0	4.1	3.7	-0.7	1.0	3.3	3.6	3.7	-2.9	-3.9	-1.7	-2.8
Pulse wave Arterial Stiffness index	1.5	1.7	3.1	-0.5	-1.6	0.8	-0.5	-1.4	-1.5	-1.5	-0.5	1.7	1.5	1.7
Impedance of arm (left)	0.8	3.8	7.9	-0.1	-2.7	-2.0	-1.7	-1.1	-2.3	-1.3	2.5	2.2	-2.8	-0.3
Arm fat mass (right)	0.2	0.9	3.7	0.5	-0.4	1.4	0.0	-0.3	0.6	-0.5	-1.9	-0.1	1.4	1.2
Trunk predicted mass	1.4	7.9	22.0	3.1	3.2	2.0	1.5	2.5	3.6	2.9	-4.7	-3.0	1.4	0.1
Standing height	0.4	3.5	14.6	3.8	1.1	-0.0	-0.5	1.5	1.8	2.2	-3.0	-1.2	-1.3	-0.0
Length of working week for main job	0.4	0.5	1.6	0.6	0.4	0.9	0.3	0.8	0.8	0.4	0.0	-0.7	-0.5	-1.3
Exposure to tobacco smoke at home	0.4	0.4	1.0	-0.3	-0.5	-0.5	-0.7	-0.6	-0.4	-0.6	-0.3	0.6	1.0	1.0
Breastfed as a baby	1.6	1.9	3.7	1.9	1.7	1.2	0.8	1.4	1.2	1.6	-1.7	-1.6	-0.6	-0.9
Tense / ‘highly strung’	1.5	2.4	4.8	-2.2	-1.3	-0.5	-0.4	-1.5	-1.9	-1.8	1.3	2.0	1.5	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	2.8	-1.2	-1.6	0.7	-0.9	-1.3	-0.9	-1.7	0.8	1.5	1.5	1.4
Hair/balding pattern: Pattern 4	0.2	0.6	3.1	1.8	0.2	-0.0	-0.1	0.1	0.6	0.9	-1.3	-0.2	0.3	0.6
Birth weight of first child	1.7	3.1	9.9	3.1	1.6	0.8	0.7	1.6	2.1	2.0	-2.0	-1.8	-1.0	-0.9
Peak expiratory flow (PEF)	1.8	4.3	8.5	2.9	2.6	0.1	0.1	1.9	2.3	2.5	-2.2	-2.8	-0.6	-1.9
Pulse wave reflection index	2.9	3.6	7.2	-1.1	-2.7	-1.1	-1.8	-2.5	-2.2	-2.4	1.2	2.5	0.2	1.6
Ever highly irritable/argumentative for 2 days	1.1	1.4	4.7	-1.9	-0.5	-0.7	-1.2	-1.4	-1.0	-0.9	2.2	0.6	-0.2	-0.3
Loud music exposure frequency	0.5	0.6	2.4	-0.7	-0.1	0.6	0.0	-0.7	-0.7	-0.3	0.1	0.7	1.6	1.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	-0.1	-0.4	-0.1	-0.5	-0.1	-0.5	-0.3	0.2	0.1	-0.9	-0.4
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	12.0	-3.5	-1.4	0.9	0.5	-1.4	-1.9	-1.6	1.7	2.0	1.7	2.3
Blood clot in the leg (DVT)	0.2	0.2	1.7	-0.1	0.1	1.3	0.4	-0.4	-0.5	-0.0	-0.2	-0.1	-0.2	0.4
Medication: Paracetamol	0.2	0.3	1.7	-0.5	0.2	-0.1	-0.1	0.3	-0.4	-0.1	0.2	0.4	1.3	1.0
Headache pain in last month	0.2	0.3	1.1	-0.5	0.2	-0.4	1.0	0.4	-0.2	0.3	0.8	-0.1	-0.5	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.3	1.3	0.6	-0.6	0.4	0.7	0.7	1.0	-0.1	-1.0	-1.5	-0.7
Glaucoma (self-reported)	0.4	0.4	1.5	0.5	0.0	0.7	1.2	0.6	0.8	0.7	-0.6	-0.7	0.5	0.1
Gout (self-reported)	0.2	0.2	1.2	0.6	0.4	-0.5	0.2	0.2	-0.3	0.1	-1.1	-0.0	0.3	0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.8	-1.1	0.3	0.2	-0.5	-0.5	-0.2	-0.3	0.5	0.2	1.3	0.3
Medication: Amlodipine	1.2	1.6	3.6	-1.9	-1.0	-0.2	-0.7	-1.4	-1.4	-1.7	0.5	1.3	1.4	1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.8	1.4	-0.4	0.5	0.9	1.0	1.0	0.6	-0.6	-0.3	-1.9	-0.9
Birth weight	1.7	3.7	13.5	3.7	1.2	-1.3	-0.2	1.6	2.0	1.9	-2.2	-1.8	-2.0	-1.1
Chronic bronchitis/emphysema (mother)	0.8	1.0	3.6	-1.0	-0.9	-0.4	-1.0	-1.1	-1.1	-1.0	1.9	0.7	-0.3	-0.2
High blood pressure (siblings)	0.8	1.2	2.2	-1.2	-1.5	-0.9	-1.1	-1.2	-0.8	-1.5	1.0	1.1	0.3	0.9
Forced vital capacity (FVC), Best measure	2.4	8.6	14.9	3.9	3.6	-0.9	0.9	3.2	3.6	3.5	-2.7	-3.6	-1.6	-2.7
Body fat percentage	0.5	1.8	3.8	-0.7	-2.0	1.1	-0.7	-1.7	-1.1	-1.9	-0.2	1.5	1.1	1.6
Leg fat percentage (right)	0.7	2.6	5.1	-2.0	-2.0	1.1	-0.3	-1.8	-1.4	-2.3	0.2	1.8	1.8	1.7
Arm fat-free mass (right)	1.3	6.6	16.9	2.6	3.1	2.4	1.5	2.1	3.2	2.6	-4.1	-2.9	1.3	-0.0
Exposure to tobacco smoke outside home	0.4	0.5	1.0	-0.4	0.9	0.2	0.9	0.6	0.9	0.6	-1.0	-0.7	0.9	-0.2
Comparative body size at age 10	0.7	2.1	3.6	1.7	1.3	1.3	1.9	1.8	1.3	1.9	-1.2	-1.4	-0.6	-0.8
Number of full brothers	1.0	1.2	2.6	-0.8	-1.3	-0.6	-1.1	-1.5	-0.8	-1.6	0.7	1.2	1.3	0.8
Worry too long after embarrassment	3.0	5.1	14.1	-1.2	-2.2	-2.2	-3.8	-2.7	-2.3	-2.3	1.6	2.4	1.1	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.4	0.9	0.7	1.6	0.9	1.0	0.8	1.2	-0.2	-0.9	-1.3	-0.9
Wheeze or whistling in the chest in last year	0.6	1.2	2.5	-1.6	-1.3	1.0	1.4	-0.4	-0.8	-1.1	1.2	1.2	-0.6	0.5
Number of children fathered	0.5	0.6	2.9	-0.4	-0.9	-0.0	1.2	0.8	0.2	0.3	0.3	0.6	-1.7	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	0.1	0.4	-1.0	-0.1	0.2	0.6	0.2	0.3	-0.4	-0.2	-0.7
Age at first live birth	0.3	0.6	1.5	0.9	0.6	0.8	1.0	1.0	-0.2	1.2	-0.5	-0.1	-1.0	0.1
Pulse wave peak to peak time	1.8	2.1	3.5	0.8	1.7	-0.6	0.7	1.7	1.7	1.8	0.3	-1.9	-1.7	-1.8
Health satisfaction	0.6	0.8	2.8	-1.7	0.1	-0.3	-0.6	-1.0	-0.5	-0.9	0.9	0.6	1.3	0.2
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.4	-0.0	-0.5	0.4	0.2	0.5	-0.3	-0.2	0.2	0.2	-0.3
Qualifications: College or University degree	1.5	4.8	11.1	3.3	2.4	0.3	0.9	2.5	2.3	2.6	-1.9	-2.4	-1.9	-2.2
Eye problems/disorders: None of the above	0.7	0.8	2.0	-1.4	0.2	-1.4	-1.2	-0.5	-0.5	-1.0	0.8	0.4	0.8	0.5
Mouth/teeth dental problems: Loose teeth	1.1	1.3	5.9	-1.5	0.2	-1.8	-0.0	-0.1	-0.7	-0.3	2.4	0.1	-0.8	-1.5
Emphysema/chronic bronchitis	0.9	1.0	6.2	-1.3	-0.2	1.6	2.5	0.8	0.2	0.1	0.3	0.4	-0.1	0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	2.2	1.3	-0.8	-0.8	0.0	0.3	0.3	0.4	-0.4	0.1	-1.5	-0.6
Neck or shoulder pain in last month	0.7	1.1	3.1	0.2	0.8	1.8	1.8	0.9	0.5	0.8	-0.9	-0.9	1.2	0.4
Medication: Blood pressure	0.5	0.9	3.2	-1.4	-0.3	0.1	-0.9	-0.8	-0.8	-0.9	0.4	0.9	1.8	0.8
Angina (self-reported)	1.7	2.2	3.8	-1.8	-1.6	0.9	-0.9	-1.6	-1.9	-1.6	1.5	1.9	0.7	1.4
Migraine (self-reported)	0.6	0.8	4.4	0.1	-0.2	-2.1	-1.1	-0.5	-1.2	-0.2	0.7	0.8	-0.1	0.3
Medication: Ibuprofen	0.6	0.7	1.4	-0.0	1.1	-0.8	0.9	0.8	1.0	0.7	-0.2	-1.2	-0.9	-0.9
Medication: Allopurinol	0.5	0.6	2.7	0.8	0.6	-0.6	0.8	0.6	0.3	0.4	-1.6	-0.5	0.8	0.9
Medication: Omeprazole	0.8	1.0	7.2	-1.0	0.0	0.4	-0.5	-0.8	0.1	-0.8	-0.3	0.4	2.7	1.1
Medication: Seretide 50 evohaler	1.4	1.7	10.2	-1.3	0.2	3.2	1.5	0.7	0.8	0.0	0.0	-0.2	1.7	-0.3
Mean time to correctly identify matches	0.9	1.7	4.3	-1.3	-1.6	0.6	-0.6	-1.6	-1.5	-2.1	1.1	1.5	-0.3	0.8
Heart disease (mother)	0.9	1.1	4.8	-1.1	-0.2	-0.6	-0.7	-0.3	-0.1	-0.8	-0.5	0.6	2.2	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	4.0	-1.8	-1.6	0.3	-0.2	-1.1	-1.4	-1.6	0.4	2.0	0.8	1.8
Whole body fat mass	0.2	1.0	2.1	0.1	-0.9	1.3	-0.4	-0.9	-0.2	-1.0	-1.5	0.6	1.4	1.5
Leg fat mass (right)	0.2	0.9	2.4	-0.4	-0.8	1.1	-0.2	-0.8	-0.2	-1.1	-1.1	0.6	1.5	1.4
Arm predicted mass (right)	1.2	6.2	16.6	2.7	2.8	2.3	1.5	2.1	3.0	2.6	-4.1	-2.7	1.1	0.2
Pulse rate, automated reading	2.6	8.4	15.3	-2.3	-3.7	-1.8	-2.5	-3.2	-3.7	-3.1	2.2	3.9	1.1	2.9
Alcohol intake frequency.	0.4	1.0	5.3	-0.8	0.5	-0.6	-0.8	-0.4	-0.5	-0.6	-0.6	0.3	2.3	1.5
Comparative height size at age 10	0.6	3.6	12.3	3.5	1.0	1.8	0.7	1.7	1.7	2.6	-2.6	-1.4	-0.9	0.2
Number of full sisters	0.5	0.6	1.4	1.2	0.9	0.2	0.4	1.1	0.7	0.8	-1.1	-0.6	-0.3	-0.2
Suffer from ‘nerves’	2.6	4.0	7.1	-2.3	-1.6	-1.6	-2.3	-2.3	-1.9	-2.7	1.9	1.8	1.8	1.4
Overall health rating	2.0	4.4	12.1	-3.5	-1.6	-0.1	-0.4	-2.2	-1.7	-2.6	1.7	2.2	2.9	1.8
Chest pain or discomfort	1.9	2.7	9.2	-3.0	-1.2	-1.3	-0.5	-1.8	-1.5	-1.8	2.4	1.4	0.9	0.4
Had major operations	1.7	1.9	6.8	-0.9	0.2	2.2	2.6	1.4	1.2	0.8	-0.7	-0.1	1.9	0.5
Age at last live birth	0.9	1.3	4.4	0.9	1.1	2.1	1.4	1.4	0.2	1.5	-1.0	-0.7	0.2	0.4
Family relationship satisfaction	0.8	1.0	4.4	-0.7	0.4	-0.4	-1.8	-1.1	0.1	-0.8	-0.3	0.1	2.1	0.6
Leg pain on walking	0.6	0.8	4.0	-0.2	0.1	2.0	1.0	0.9	0.9	0.7	-0.8	-0.6	0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	7.5	0.2	-0.6	2.7	0.6	0.1	0.2	-0.6	-1.1	0.5	0.4	1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.4	-1.0	-0.8	-0.1	-1.0	-1.1	-0.8	-1.5	0.1	1.3	1.4	1.5
Illness, injury, bereavement, stress in last 2 years	2.8	3.5	9.7	1.2	1.7	0.3	1.8	1.8	1.5	2.1	0.0	-2.0	-2.6	-3.1
Medication: Aspirin	1.3	1.7	3.4	-1.4	-0.5	0.4	-1.7	-1.8	-1.7	-1.6	0.9	1.3	1.2	1.1
Supplements: Vitamin C	1.2	1.4	8.4	0.7	0.6	-0.2	0.9	1.1	0.3	1.0	0.6	-0.6	-2.9	-1.4
Knee pain experienced in last month	0.9	1.4	3.5	-1.9	-1.0	-0.9	-1.2	-1.3	-1.1	-1.5	1.5	0.9	1.0	0.3
Hypertension (Self-reported)	1.7	4.7	7.0	-2.6	-2.1	-0.6	-1.8	-2.4	-2.6	-2.6	1.3	2.5	2.1	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	-0.7	-0.6	1.0	0.5	-0.3	-0.4	-0.8	0.8	1.0	-0.0	0.1
Illnesses of father: Heart disease	5.1	7.1	11.2	-3.0	-2.6	-2.9	-2.3	-2.8	-3.0	-2.7	3.4	3.2	0.3	1.5
Illnesses of siblings: Diabetes	1.3	1.7	3.8	-0.6	-1.3	0.1	-1.4	-1.9	-0.8	-1.3	0.4	1.3	1.9	1.6
Smoking status: Previous	1.1	1.6	4.9	0.3	0.8	2.2	1.7	0.8	1.2	0.3	-1.8	-0.6	1.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	3.3	1.8	0.1	-0.8	-0.4	0.4	0.5	0.7	-0.6	-0.3	-1.4	-0.7
Whole body fat-free mass	1.2	7.1	22.3	3.2	2.7	2.2	1.2	2.3	3.2	2.6	-4.7	-2.7	1.2	0.4
Leg fat-free mass (right)	1.0	5.4	19.4	3.3	2.0	1.9	0.6	1.8	2.7	2.1	-4.4	-2.2	1.0	0.7
Arm fat percentage (left)	0.1	0.6	1.4	0.1	-1.1	1.2	0.1	-0.5	0.0	-0.9	-1.0	0.4	0.7	0.9
Average weekly red wine intake	1.2	1.7	4.1	1.3	1.0	0.3	1.1	1.6	1.0	1.5	0.1	-1.4	-1.8	-2.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	-0.6	-0.4	0.3	-0.2	-0.4	-0.7	-0.6	0.1	0.6	0.6	1.1
Mood swings	0.7	1.3	4.0	-2.0	-1.2	0.3	-0.2	-0.9	-0.9	-1.6	1.3	1.4	0.3	0.6
Loneliness, isolation	0.6	0.9	2.8	-1.7	-0.5	-0.4	-1.1	-0.9	-1.2	-1.1	1.0	0.6	0.4	0.1
Long-standing illness, disability or infirmity	0.7	1.1	5.4	-0.7	0.6	0.8	-0.3	-0.6	-0.5	-0.4	-1.1	0.4	2.3	1.6
Ever had bowel cancer screening	1.7	2.0	8.8	-1.0	-0.9	1.4	-0.3	-0.9	-0.9	-1.1	-1.0	1.4	3.0	1.9
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.1	-0.6	0.5	0.4	0.0	0.3	-0.2	-0.1	0.2	-0.5	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.8	0.6	1.3	-0.2	0.2	0.8	0.8	0.9	0.4	-1.1	-0.3	-1.3
Friendships satisfaction	0.5	0.6	1.3	0.8	1.1	-0.9	-0.1	0.4	0.9	0.5	-0.2	-0.9	-0.0	-1.2
Qualifications: nursing, teaching	2.7	4.2	8.0	2.2	2.5	0.8	1.4	2.2	1.9	2.5	-1.6	-2.8	-0.9	-2.4
Commuting to job workplace: Walk	0.1	0.2	0.6	0.2	0.2	-0.8	-0.2	0.2	0.6	0.3	-0.3	-0.5	0.0	-0.2
Eye problems/disorders: Cataract	1.3	1.5	4.5	1.1	0.6	2.1	1.5	1.3	0.8	1.4	-1.8	-0.8	0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.8	-0.4	-1.4	-0.3	-1.1	-1.2	-0.9	-1.0	0.3	1.3	0.2	1.2
Medication for cholesterol	0.4	0.6	0.9	0.6	0.8	0.9	0.7	0.9	1.0	0.9	-0.7	-0.8	-0.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.9	0.6	1.2	0.6	1.7	1.7	1.6	1.5	-0.4	-1.5	-0.7	-0.6
Back pain experienced in last month	0.2	0.4	1.0	-0.7	-0.0	-0.6	-0.7	-0.5	-0.2	-0.7	0.1	0.1	1.0	0.8
Mineral and other dietary supplements	0.8	1.0	4.6	-0.4	-0.5	-2.1	0.5	0.4	0.4	0.2	1.5	-0.1	-1.3	-1.3
Breast cancer (self-reported)	0.4	0.5	1.1	-0.6	0.8	-0.5	0.7	0.6	0.6	0.4	0.4	-0.8	1.1	-1.0
Asthma (self-reported)	2.1	4.3	9.9	1.5	1.2	3.1	2.4	2.5	2.3	2.0	-1.5	-1.9	-1.8	-1.7
Osteoporosis (self-reported)	1.1	1.3	3.2	0.0	-1.8	1.3	-0.7	-0.9	0.3	-0.9	-1.2	0.7	1.6	1.7
Osteoarthritis (self-reported)	0.1	0.2	0.8	0.0	0.5	0.6	0.2	0.1	0.1	0.7	0.3	-0.1	0.9	0.0
Medication: Aspirin	1.7	2.2	4.0	-1.7	-0.6	0.6	-1.7	-2.0	-1.8	-1.9	0.9	1.3	1.7	1.1
Medication: Gliclazide	0.4	0.4	1.4	-0.6	-0.7	1.2	0.6	-0.3	-0.6	-0.5	1.0	0.6	-0.3	0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	2.7	1.6	-0.5	0.5	-1.0	0.0	0.4	0.0	-1.7	-0.2	0.2	0.8
Smoking status: Current	0.4	0.7	2.9	-1.3	-0.4	-1.1	-0.4	-0.5	-0.4	-0.7	1.7	0.4	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.4	10.6	2.2	3.3	0.7	1.7	2.8	2.7	2.8	-2.2	-3.1	-0.1	-1.9
Whole body water mass	1.3	7.4	22.5	3.3	2.9	2.2	1.3	2.3	3.3	2.7	-4.7	-2.8	1.1	0.3
Leg predicted mass (right)	1.0	5.6	19.9	3.4	2.1	2.0	0.7	1.8	2.8	2.2	-4.5	-2.2	1.0	0.7
Arm fat mass (left)	0.2	0.9	3.7	0.6	-0.2	1.6	0.3	-0.0	0.9	-0.2	-1.9	-0.3	1.2	0.8
Number of self-reported non-cancer illnesses	2.0	3.4	6.4	-1.9	-1.5	0.5	-1.4	-2.1	-2.3	-2.2	0.3	2.1	2.5	2.1
Average weekly champagne plus white wine intake	0.2	0.3	1.7	0.2	-0.5	1.3	0.2	0.3	-0.1	0.1	-0.6	-0.2	-0.5	0.3
Miserableness	2.2	3.7	6.0	-2.2	-2.0	-1.3	-1.8	-1.9	-2.2	-2.1	2.2	2.4	0.8	1.6
Guilty feelings	0.6	0.8	2.1	-0.5	-1.1	-1.0	-1.4	-0.7	-0.6	-0.7	-0.0	1.3	0.5	1.2
Wears glasses or contact lenses	0.4	0.4	1.3	-0.5	-1.1	-0.0	-0.6	-0.5	-0.2	-0.2	1.1	0.5	0.8	0.1
Ever taken oral contraceptive pill	4.0	4.5	9.4	1.8	1.6	0.6	2.6	2.5	2.7	1.8	-1.2	-2.0	-2.2	-3.1
Hearing aid user	0.9	1.1	6.8	-0.3	0.7	1.0	2.6	1.1	0.4	1.0	-0.5	-0.6	0.1	-0.7
Mother’s age at death	0.2	0.2	0.8	-0.1	0.4	-0.2	-0.9	-0.7	-0.5	-0.2	0.4	0.1	0.6	-0.6
Financial situation satisfaction	0.1	0.2	0.6	-0.7	0.5	-0.2	-0.2	-0.2	0.1	-0.2	0.6	-0.2	0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	-0.6	0.7	-0.1	0.5	0.2	1.0	0.1	-0.1	-0.5	0.8	-0.5
Commuting to job workplace: Public transport	1.0	1.1	4.1	0.4	0.8	0.1	1.3	1.0	0.7	1.3	0.3	-1.2	-1.1	-2.0
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	0.3	0.5	0.5	1.1	0.4	0.8	0.8	0.1	-1.0	0.0	-0.8
Medication: Blood pressure	0.8	1.5	3.1	-0.9	-1.0	-0.8	-1.1	-1.5	-1.6	-1.2	0.2	1.1	1.7	1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.7	-0.3	-1.3	-1.1	-1.1	-0.8	-0.5	-0.7	-0.0	1.1	0.9	1.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.0	-0.4	-1.0	0.6	-0.8	-1.1	-1.3	-1.0	0.2	1.3	0.1	1.4
High cholesterol (Self-reported)	0.7	1.2	6.4	-2.5	0.2	0.4	-0.1	-0.8	-0.7	-0.7	1.2	0.6	1.7	0.5
Medication: Bendroflumethiazide	1.7	2.7	6.0	-1.3	-1.8	-1.1	-2.2	-1.9	-1.5	-2.5	0.4	1.5	1.5	1.4
Medication: Paracetamol	0.4	0.7	3.2	-0.1	0.2	0.5	0.2	0.5	0.3	0.2	-0.9	0.2	1.8	1.7
Medication: Lisinopril	0.6	0.8	2.2	-1.1	1.1	1.5	1.5	0.6	0.4	0.2	0.7	-0.5	0.6	-0.5
Medication: Atorvastatin	0.8	1.0	2.3	0.7	0.9	1.5	1.3	1.0	0.9	0.9	-1.3	-1.0	0.0	0.1
Illnesses of father: High blood pressure	1.2	1.5	6.0	-1.6	-0.6	-2.5	0.5	-0.5	-1.2	-0.4	2.1	0.8	-0.8	-0.2
Alcohol drinker status: Never	0.8	0.9	2.7	-0.2	0.4	1.6	0.7	0.3	1.2	-0.4	-1.6	-0.7	1.6	0.2
Ever smoked	0.3	0.6	2.7	-1.1	0.2	0.6	0.9	0.1	0.5	-0.5	-0.5	0.2	1.7	0.9
Basal metabolic rate	1.0	5.3	18.2	2.8	2.2	1.9	1.0	1.8	2.8	2.1	-4.3	-2.2	1.3	0.6
Leg fat percentage (left)	0.7	2.7	4.7	-1.9	-1.8	1.3	-0.3	-1.9	-1.4	-2.2	0.2	1.7	2.0	1.7
Arm fat-free mass (left)	0.9	4.6	14.8	2.1	2.3	2.1	0.9	1.5	2.6	1.9	-3.8	-2.1	1.7	0.7
Number of operations (self-reported)	0.4	0.6	3.3	-1.3	-0.1	1.1	0.6	0.1	0.1	-0.3	0.1	0.2	1.8	0.2
Average weekly beer plus cider intake	1.1	1.5	3.8	1.7	0.7	1.2	0.9	1.2	1.9	1.1	-1.5	-1.2	-0.9	-0.8
Irritability	2.3	3.8	7.8	-2.8	-2.0	-1.8	-1.3	-1.9	-2.1	-2.4	1.9	2.4	1.1	1.1
Risk taking	0.3	0.4	1.4	0.3	0.5	-0.6	-0.9	-0.1	0.6	0.6	-1.2	-0.9	0.4	-0.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.6	1.1	0.3	0.3	0.8	1.0	1.0	0.9	-1.3	-0.8	-0.4	-0.8
Fractured/broken bones in last 5 years	1.9	2.4	4.3	0.8	1.8	0.8	1.8	1.9	2.0	2.1	-1.4	-2.0	-0.4	-1.0
Age started oral contraceptive pill	0.6	0.8	2.2	-0.1	-1.4	-0.1	-0.7	-0.5	-1.5	-0.7	0.3	1.5	-0.7	0.7
Diastolic blood pressure, automated reading	1.0	3.1	7.0	-0.8	-2.6	-0.7	-1.3	-1.9	-2.6	-1.2	1.8	2.4	-0.6	1.8
Ever depressed for a whole week	3.2	3.9	7.4	2.0	2.6	1.2	0.9	1.7	2.3	2.4	-1.0	-2.7	-1.8	-2.1
Unable to work because of sickness or disability	0.3	0.4	1.8	-0.7	0.0	0.7	0.2	-0.2	-0.3	0.3	0.4	0.4	1.3	0.9
Commuting to job workplace: Cycle	1.8	2.2	4.2	1.4	2.1	-0.1	0.8	1.8	1.7	1.9	-1.8	-1.9	-0.5	-0.6
Myopia	2.3	3.3	5.6	-0.7	-2.2	-1.2	-2.3	-2.4	-1.9	-2.2	1.1	2.2	1.1	1.9
Vascular/heart problems diagnosed by doctor	1.8	4.9	7.3	2.5	2.1	0.7	2.1	2.6	2.7	2.6	-1.6	-2.6	-1.9	-2.1
Cholesterol lowering medication	0.2	0.3	1.3	-1.2	-0.4	0.8	0.0	-0.4	-0.5	-0.4	0.9	0.3	-0.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	8.3	-0.9	-0.6	0.6	-0.8	-1.1	-0.3	-0.9	-0.5	0.8	2.9	1.7
Pain experienced in last month	0.2	0.4	1.3	0.7	-0.3	-0.4	-0.5	0.1	0.6	-0.2	0.0	-0.1	-1.1	-1.1
Supplements: Calcium	0.5	0.6	1.6	-0.6	0.7	-1.2	-1.3	-0.6	-0.5	-0.6	0.5	-0.4	0.8	-0.4
Basal cell carcinoma (self-reported)	0.7	0.9	3.8	1.0	-0.5	1.9	1.2	0.8	-0.2	0.5	-0.9	0.1	-0.9	0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.3	-1.1	-0.4	0.6	-0.8	-0.9	-0.7	-1.1	0.4	0.7	1.0	0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.5	0.3	0.6	1.6	1.0	0.2	0.0	0.5	-0.4	-0.7	-0.7	-0.3
Heart disease (siblings)	4.6	5.6	9.2	-2.1	-2.6	-1.1	-2.6	-2.5	-2.0	-2.8	0.6	2.8	2.6	3.0
Alcohol drinker status: Previous	0.4	0.5	1.5	1.2	0.2	-0.4	-0.5	0.7	-0.6	1.0	-0.4	0.2	-0.3	1.0
Pack years of smoking	3.5	5.1	9.5	-3.1	-2.4	-1.1	-1.6	-2.3	-2.4	-2.5	2.0	2.9	1.7	2.3
Impedance of whole body	1.4	7.0	16.6	-1.6	-3.2	-2.6	-2.2	-2.3	-3.3	-2.2	4.1	3.1	-2.5	-0.1
Leg fat mass (left)	0.2	1.0	3.0	-0.5	-0.7	1.2	-0.2	-1.0	-0.2	-1.0	-1.1	0.5	1.7	1.4
Arm predicted mass (left)	1.0	5.0	15.9	2.1	2.5	2.2	0.9	1.5	2.8	1.9	-4.0	-2.2	1.9	0.7