Hub : Genes

CDAN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0430 0.0220 1.6e-03 0.015 0.023 0.002 0.022 0.011 4.9e-03 0.00079 1.8e-01 0.00088 1.5e-02
2 GTEx Artery Aorta 0.0910 0.0410 2.0e-04 0.078 NA 0.075 NA 0.072 4.4e-05 NA 6.3e-05 NA 8.5e-05
3 GTEx Brain Cerebellar Hemisphere 0.4370 0.1110 5.4e-05 -0.009 NA 0.011 NA 0.009 6.5e-01 NA 1.6e-01 NA 1.8e-01
4 GTEx Brain Cerebellum 0.2370 0.0910 8.4e-05 0.049 NA 0.024 NA 0.068 1.5e-02 NA 6.5e-02 NA 4.6e-03
5 GTEx Brain Cortex 0.1040 0.0530 3.5e-03 0.024 NA 0.037 NA 0.055 7.1e-02 NA 3.5e-02 NA 1.2e-02
6 GTEx Nerve Tibial 0.1908 0.0556 6.2e-09 0.179 NA 0.137 NA 0.149 9.5e-13 NA 6.7e-10 NA 9.7e-11
7 GTEx Testis 0.1510 0.0580 6.8e-06 0.159 NA 0.106 NA 0.137 1.5e-07 NA 2.0e-05 NA 1.1e-06
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0513 0.0315 6.8e-04 0.023 0.028 0.010 NA 0.018 1.0e-03 0.00036 2.6e-02 NA 3.9e-03
9 TCGA Liver Hepatocellular Carcinoma 0.1300 0.1250 4.2e-03 0.037 0.054 0.036 NA 0.032 7.2e-03 0.00140 7.9e-03 NA 1.2e-02
10 TCGA Stomach Adenocarcinoma 0.0710 0.0510 9.2e-03 0.026 0.007 0.031 NA 0.028 5.6e-03 0.09000 2.7e-03 NA 3.9e-03
11 TCGA Thyroid Carcinoma 0.0380 0.0250 2.1e-03 0.003 0.027 0.013 NA 0.010 1.5e-01 0.00100 1.6e-02 NA 3.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 3.8 5.9 10.4 2.6 2.2 0.8 2.6 3.2 2.9 2.9 -2.8 -2.6 -1.2 -1.8
Bipolar Disorder or Schizophrenia 2.2 5.3 10.5 1.2 2.5 1.0 3.2 3.1 2.8 2.1 -2.4 -2.4 -0.6 -2.2
Depressed Affect (Nagel 2018) 2.7 5.7 13.2 -3.6 -2.0 -1.2 -1.5 -2.6 -2.6 -3.2 3.0 2.6 1.2 1.3
Depression (Nagel 2018) 0.9 1.4 5.2 0.2 2.3 1.5 0.9 1.1 1.4 0.9 -0.8 -1.4 0.5 -0.7
Intelligence (Savage-Jansen 2018) 0.6 1.8 7.3 1.6 0.6 -0.9 -0.8 0.6 0.1 1.0 0.9 -1.0 -2.7 -2.3
Neuroticism (Nagel 2018) 3.4 8.0 14.1 -3.7 -2.7 -1.9 -2.5 -3.2 -3.1 -3.8 2.9 3.2 1.7 1.6
Schizophrenia (2018) 0.7 1.4 4.3 -0.6 1.5 0.8 2.1 1.4 1.4 0.4 -0.7 -1.1 0.0 -1.4
Schizophrenia vs Biploar Disorder 3.2 4.2 7.7 -2.8 -2.5 -0.9 -1.6 -2.1 -1.9 -2.6 2.4 2.5 0.6 1.3
Worry (Nagel 2018) 2.7 5.8 10.1 -3.0 -2.4 -1.1 -1.8 -2.7 -2.9 -3.2 3.0 2.8 0.4 1.1
Alzheimer’s Disease (in mother) 1.0 1.1 3.3 -1.8 -0.9 0.8 0.1 -1.2 -1.1 -0.6 0.9 1.3 0.4 1.4
Alzheimer’s Disease (in father) 0.9 1.0 3.1 1.8 0.8 1.6 -0.1 0.7 0.9 1.2 -1.2 -0.7 -0.3 -0.4
Alzheimer’s Disease (including proxy) 0.3 0.4 2.1 -0.4 -0.4 1.5 -0.2 -0.9 -0.3 -0.0 0.3 0.7 0.3 0.9
Crohns Disease (2017) 0.2 0.4 2.9 -0.6 0.1 -0.1 -0.8 -0.5 -0.5 -0.4 0.1 0.3 1.7 0.2
Irritable Bowel Disease (IBD) 0.4 0.9 2.4 -0.7 -0.4 -1.0 -1.5 -0.9 -0.7 -1.5 -0.0 0.8 1.0 0.5
Ulcerative Colitis (UC) 0.3 0.6 2.3 -0.3 -0.3 -1.1 -1.3 -0.6 -0.1 -1.5 -0.6 0.4 0.2 0.4
Major Depression (MDD) 0.3 0.4 1.3 -0.3 1.1 0.1 0.0 0.3 0.8 -0.1 0.1 -0.7 -0.5 -1.1
Reaction Time 2.4 4.6 9.4 -2.2 -2.2 -1.4 -1.4 -2.6 -2.4 -3.0 3.1 2.4 -0.9 0.4
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.7 0.7 0.2 -0.9 -0.9 0.0 -0.6 0.1 1.3 -0.2 -0.9 -1.1
Breast Cancer 0.2 0.4 2.3 0.1 -1.5 0.6 0.3 -0.2 -0.4 -0.2 0.1 0.7 -1.2 0.4
Ovarian Cancer 0.2 0.2 0.8 0.3 -0.9 0.7 -0.3 0.3 -0.3 -0.0 -0.5 0.3 0.4 0.7
Prostate Cancer 0.4 0.5 3.6 -1.9 -0.4 -0.6 -0.0 -0.3 -0.2 -0.5 1.0 0.5 0.5 -0.1
Age at First Birth 0.8 1.1 5.6 1.1 0.2 0.9 0.9 0.8 0.1 1.2 -0.1 -0.3 -2.4 -1.2
Bipolar Disorder (2011) 10.6 10.3 17.2 3.9 3.6 1.6 3.2 3.9 3.3 4.2 -2.9 -3.3 -2.0 -2.2
Body Mass Index (BMI) (2010) 1.9 2.6 6.5 0.7 2.0 1.8 1.1 1.5 2.6 1.3 -1.7 -2.1 0.3 -1.6
Coronary Artery Disease (CAD) 0.2 0.2 1.1 -0.0 -0.0 -0.3 1.1 0.6 0.6 0.1 -0.1 -0.4 -0.3 0.3
Crohns Disease (2012) 0.1 0.2 0.6 -0.0 -0.3 0.4 0.1 0.5 0.1 0.4 0.4 -0.2 0.8 -0.5
Mean Putamen Volume 0.5 0.5 1.5 0.6 -0.4 0.4 -0.8 -0.5 -0.4 0.3 -0.8 0.6 1.2 1.2
Fasting Glucose 0.6 0.7 2.1 0.1 0.0 0.9 1.4 0.9 1.4 0.1 -1.4 -0.4 0.6 0.3
HbA1C 1.7 1.8 3.1 0.8 1.4 1.4 1.8 1.4 1.7 1.4 -1.3 -1.7 -1.0 -0.3
HDL Cholesterol 0.3 0.6 1.5 0.7 -1.1 -0.4 -0.6 -0.9 -0.8 -0.6 -0.4 0.9 -0.2 1.2
LDL Cholesterol 0.1 0.2 0.4 0.5 0.1 0.5 0.6 0.4 0.4 0.2 -0.4 -0.6 -0.2 -0.5
Lupus 0.3 0.4 1.5 0.8 -0.0 -1.2 0.2 0.8 0.2 0.7 -0.1 -0.1 -1.0 -0.5
Neuroticism (2016) 2.5 3.5 6.0 -2.0 -2.4 -1.5 -1.9 -1.6 -1.6 -2.4 1.0 2.2 1.7 1.9
Primary Biliary Cirrhosis 0.8 1.1 2.3 1.1 1.2 0.9 1.2 1.2 1.1 1.5 -0.8 -1.1 -0.1 -0.6
Rheumatoid Arthritis 0.1 0.2 0.7 -0.5 -0.4 -0.3 -0.3 -0.1 -0.3 -0.5 0.2 0.3 0.9 0.7
Schizophrenia (2014) 0.6 1.4 4.2 -0.4 1.3 0.3 2.0 1.6 1.4 0.4 -0.9 -1.1 0.2 -1.7
Triglycerides 0.2 0.3 0.9 -0.6 0.8 0.9 0.4 0.4 0.6 -0.0 -0.4 -0.4 0.8 -0.1
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.6 -0.3 -0.0 -0.2 0.1 0.1 0.9 0.1 0.9 -0.2 -1.0 -1.3
Ulcerative Colitis 0.2 0.3 1.2 -0.7 -0.6 -0.8 -0.0 0.2 0.0 -1.1 -0.2 0.4 -0.1 -0.0
Blood Eosinophil Count 0.1 0.8 2.1 -1.0 -1.0 1.1 -0.2 -1.2 -0.9 -0.4 1.4 0.9 -0.3 0.3
Blood Platelet Count 1.1 13.0 25.3 -4.3 -3.6 -2.5 -2.5 -2.9 -5.0 -3.8 4.9 4.7 -0.5 2.1
Blood Red Count 0.3 2.8 16.8 0.4 0.4 -0.7 -4.1 -2.5 -0.8 -1.0 -0.5 -0.1 2.2 0.2
Blood White Count 2.0 14.5 29.1 -5.4 -3.6 -2.9 -2.4 -4.1 -4.5 -4.6 5.0 4.1 0.9 1.5
Heel T-Score 0.4 3.2 5.5 2.3 1.3 2.1 0.7 1.9 1.9 2.0 -2.1 -1.9 -1.4 -1.3
BMI 0.2 1.4 4.5 0.1 1.2 2.1 1.5 0.3 1.2 0.4 -1.6 -1.3 1.3 -0.3
Height 0.2 4.2 20.0 4.5 -1.0 -0.4 -2.2 0.5 0.9 1.2 -3.3 -0.0 -2.6 0.8
Waist Hip Ratio (WHR) 0.1 0.5 1.8 -1.1 -0.2 0.3 -1.2 -0.7 -0.2 -1.0 0.0 0.2 1.3 0.3
Systolic Blood Pressure 0.1 0.6 1.5 -0.7 -0.9 -0.7 0.1 -0.1 -0.8 -0.4 1.2 0.7 -1.2 -0.3
Smoking Status 0.3 0.7 4.1 -0.4 0.3 0.5 2.0 1.0 0.9 0.1 -0.5 -0.5 0.8 0.4
Allergy or Eczema 0.1 0.2 0.7 0.1 -0.2 -0.7 -0.9 -0.3 0.4 -0.5 -0.4 0.1 0.9 -0.1
Cardiovascular Disease 1.7 5.6 10.6 -3.3 -1.8 -1.0 -1.5 -2.8 -3.2 -2.5 2.2 2.8 1.9 1.9
Hypothyroidism (self reported) 0.0 0.1 0.2 -0.4 0.5 -0.1 -0.4 -0.2 -0.4 0.1 0.3 -0.2 0.5 0.3
Respiratory disease 0.2 0.4 2.0 -0.6 -0.3 1.4 0.8 0.8 0.8 -0.1 -0.2 0.1 -0.1 -0.2
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.6 -0.4 -0.1 0.2 1.3 0.6 0.8 -0.0 -0.2 0.0 -0.7 -0.5
Lung FEV1/FVC ratio 0.5 2.4 4.9 2.2 1.9 0.2 0.6 1.8 1.5 1.6 -1.8 -2.0 -0.5 -1.4
Lung FVC 1.0 4.9 8.9 2.8 3.0 0.2 0.9 2.4 2.7 2.6 -1.9 -2.8 -0.9 -2.1
Neuroticism 2.6 6.2 10.6 -3.3 -2.7 -1.2 -2.0 -2.6 -2.8 -3.1 3.1 3.0 0.3 1.2
Chronotype (morning person) 0.7 1.5 3.9 -0.2 -1.1 -1.1 -2.0 -1.2 -1.6 -1.0 0.2 1.5 -0.1 1.7
Hair Pigment 0.0 0.3 1.3 -0.2 0.9 -1.1 0.1 0.5 -0.0 0.5 -0.2 -0.6 -0.1 -0.3
Tanning 0.3 3.6 7.4 1.6 2.7 1.2 1.8 1.6 1.6 2.5 -0.4 -2.6 -1.7 -2.1
Hand grip strength (left) 0.5 1.4 8.3 0.1 0.6 0.2 -1.1 -0.4 0.2 -0.2 -1.6 0.2 2.9 1.7
Number of treatments/medications taken 0.6 1.0 4.0 -0.4 -0.3 2.0 0.1 0.1 -0.2 -0.4 -1.4 0.2 1.8 1.1
Average weekly spirits intake 0.1 0.1 0.6 -0.1 0.4 0.2 -0.1 -0.2 0.4 0.1 -0.8 -0.4 -0.1 -0.2
Sensitivity / hurt feelings 1.5 2.6 5.1 -2.1 -1.0 -1.3 -1.9 -1.7 -1.1 -2.3 0.9 1.5 1.9 1.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 2.0 -0.2 1.4 0.3 0.2 0.6 0.6 0.3 -0.2 -0.6 0.9 -0.7
Hearing difficulty/problems: Yes 0.9 1.4 4.3 0.2 2.1 0.8 1.0 1.1 1.1 1.2 -1.1 -1.4 1.2 -0.5
Relative age of first facial hair 0.5 1.0 3.8 -1.6 0.0 -0.5 -1.1 -0.3 -0.3 -1.4 0.1 0.4 1.9 0.8
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 4.2 0.6 1.9 2.0 0.7 0.8 1.2 0.8 -2.0 -1.4 1.3 -0.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 1.0 -1.0 -0.1 0.2 0.3 -0.4 0.0 -0.4 0.4 0.0 0.9 0.1
Ever had hysterectomy (womb removed) 2.1 2.4 6.7 0.4 1.1 2.6 2.6 1.5 1.7 1.6 -0.8 -1.3 -0.8 -0.7
Systolic blood pressure, automated reading 0.2 0.6 1.3 -0.6 -1.1 0.2 0.7 -0.2 -1.0 -0.3 0.9 0.9 -1.1 0.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.7 1.3 -1.3 0.1 -0.6 -0.2 -0.2 -0.0 -0.9 0.9 0.2 1.0
Angina 2.0 2.6 4.5 -1.9 -1.7 0.6 -1.1 -1.8 -2.1 -1.9 1.6 2.1 0.7 1.4
Medication for hormone replacement therapy 0.4 0.5 1.4 1.1 0.2 -0.0 0.4 0.8 1.2 0.3 -0.7 -0.5 -0.7 -0.5
Vitamin and mineral supplements 0.2 0.3 1.2 -0.4 0.5 -0.6 0.1 0.2 1.1 0.1 -0.0 -0.7 0.2 -0.8
Supplements: Zinc 2.4 2.6 6.3 -1.6 -1.0 -1.6 -1.6 -1.9 -2.5 -2.1 1.9 1.5 -0.3 0.2
Medication: Co-codamol 1.2 1.4 2.8 1.5 1.7 1.1 0.5 0.9 1.0 1.5 -1.5 -1.2 1.1 0.1
Medication: Metformin 1.2 1.7 3.9 1.5 0.8 2.0 1.2 1.1 1.7 1.1 -1.8 -1.1 -0.6 -0.7
Diabetes (father) 0.9 1.1 1.8 0.3 1.3 -0.5 1.3 1.3 1.3 1.2 -0.8 -1.2 0.8 -0.6
Diabetes (mother) 0.4 0.5 1.8 -0.8 0.2 -1.3 -0.6 -0.5 -0.2 -0.9 0.6 0.2 1.3 -0.0
Severe depression (siblings) 1.7 1.9 9.8 -0.2 -0.0 -3.1 -0.9 0.1 -0.0 -0.2 1.8 -0.0 -2.1 -1.5
Pack years adult smoking proportion 3.1 4.8 8.1 -2.8 -2.2 -1.2 -1.8 -2.4 -2.2 -2.4 1.9 2.8 1.5 2.2
Impedance of leg (right) 1.4 6.7 19.3 -2.7 -2.7 -2.6 -1.4 -2.2 -3.1 -2.3 4.4 2.9 -1.9 -0.3
Leg fat-free mass (left) 0.9 4.6 18.3 3.0 1.7 1.8 0.5 1.6 2.5 1.7 -4.3 -1.8 1.1 0.9
Trunk fat percentage 0.5 1.8 4.3 -0.5 -2.1 1.1 -0.9 -1.8 -1.3 -1.9 -0.0 1.6 0.6 1.4
Hand grip strength (right) 0.3 0.9 5.1 -0.2 0.6 -0.3 -0.8 -0.3 0.1 -0.3 -1.2 0.2 2.2 1.3
Townsend deprivation index at recruitment 0.6 0.9 1.7 -1.1 -0.5 -0.2 -0.4 -1.3 -1.2 -0.7 1.1 1.3 0.9 0.5
Current tobacco smoking 0.7 1.1 4.0 -1.7 -0.5 -1.3 -0.7 -0.9 -0.6 -1.0 2.0 0.5 0.2 -0.7
Average weekly fortified wine intake 0.4 0.5 1.7 0.2 -1.3 0.5 -0.5 -0.3 -0.6 -0.5 -0.1 1.0 -0.1 1.0
Maternal smoking around birth 1.2 1.7 5.6 -1.9 -0.8 -1.0 -1.0 -1.5 -1.3 -1.3 2.4 1.0 -0.5 -0.3
Fed-up feelings 4.6 8.4 18.8 -4.3 -2.5 -0.1 -1.1 -2.9 -2.8 -3.2 2.4 3.4 3.6 3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 1.4 -0.5 0.5 1.2 0.7 0.7 0.7 0.0 0.1 -0.4 0.1 -0.4
Relative age voice broke 2.4 3.6 5.6 -2.4 -1.0 -2.3 -2.4 -2.0 -2.2 -2.2 2.3 1.4 0.5 0.6
Taking other prescription medications 0.7 1.1 3.1 -1.4 -0.9 0.8 -0.6 -0.8 -0.6 -1.2 -0.4 0.9 1.8 1.4
Age when periods started (menarche) 0.1 0.3 1.6 0.7 -0.1 -0.5 -1.2 -0.2 -0.1 -0.1 -0.1 0.0 -0.5 -0.5
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 4.1 0.9 0.7 1.7 1.2 1.2 1.5 0.8 -2.0 -1.1 1.9 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 2.3 0.6 1.5 1.5 1.2 1.1 1.2 1.1 -0.6 -1.4 0.1 -1.1
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.4 -0.3 0.2 -0.6 0.7 0.4 -0.3 0.3 0.2 0.0 -0.1 0.2
Qualifications: CSEs or equivalent 1.7 2.2 3.9 -1.2 -1.8 -1.6 -1.0 -1.2 -1.7 -1.9 1.5 2.0 -0.2 1.4
Serious illness, injury or assault to yourself 2.0 2.4 9.6 -1.4 -0.7 0.1 -1.1 -1.4 -0.3 -1.7 -0.8 1.1 3.1 2.4
High blood pressure 1.7 4.8 7.9 -2.7 -2.0 -0.8 -1.9 -2.5 -2.8 -2.6 1.7 2.5 1.8 1.9
Hayfever, allergic rhinitis or eczema 0.2 0.5 2.3 0.4 -0.6 -1.5 -1.1 -0.4 0.5 -0.9 -0.0 0.0 -0.4 -0.5
Multivitamins +/- minerals 0.2 0.2 1.4 -0.1 -0.3 0.5 -0.2 -0.2 -1.2 -0.6 0.5 0.4 -0.1 -0.0
Stomach or abdominal pain in last month 2.1 2.6 4.1 -1.6 -1.5 -2.0 -2.0 -2.0 -1.5 -1.8 1.7 1.7 0.7 0.5
Supplements: Glucosamine 2.5 3.2 10.9 1.9 1.2 2.9 0.4 1.0 1.6 1.3 -3.3 -1.3 1.7 0.8
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.1 0.3 0.9 0.8 0.6 0.4 1.1 0.9 -0.9 -0.9 0.2 -0.0
Medication: Atenolol 0.8 1.0 3.3 -1.5 -0.7 1.2 -0.4 -0.3 -0.7 -1.0 0.1 0.6 1.8 1.0
Medication: Levothyroxine sodium 0.2 0.3 1.2 -0.4 0.1 0.7 -0.2 -0.2 -0.1 0.1 -0.7 0.3 1.1 0.9
Sitting height 0.2 1.4 4.9 1.4 -1.2 -1.6 -2.2 -0.9 -0.2 -0.4 -0.7 1.1 -0.2 1.4
Chronic bronchitis/emphysema (father) 0.9 1.1 3.3 -0.1 1.2 1.8 1.4 0.7 1.0 0.8 -1.0 -0.9 1.1 -0.2
High blood pressure (mother) 0.5 0.7 3.2 -1.0 0.7 -1.3 -0.2 -0.1 -0.4 -0.3 0.8 0.2 1.8 0.6
Body mass index (BMI) 0.3 1.2 4.5 -0.4 -0.2 1.7 0.4 -0.5 0.4 -0.7 -1.5 -0.1 2.1 1.3
Impedance of leg (left) 1.3 6.4 19.7 -2.6 -2.4 -2.3 -1.5 -2.3 -3.1 -2.2 4.4 2.7 -1.7 -0.3
Leg predicted mass (left) 0.8 4.5 17.6 2.9 1.7 1.8 0.5 1.6 2.5 1.8 -4.2 -1.8 1.1 0.8
Trunk fat mass 0.2 0.9 1.8 0.3 -1.1 1.3 -0.5 -1.0 -0.3 -1.1 -1.3 0.7 0.9 1.3
Waist circumference 0.4 1.6 5.1 -0.3 -0.1 2.2 0.3 -0.6 0.4 -0.9 -2.0 -0.1 2.3 1.3
Number of incorrect matches in round 2.4 4.0 6.8 1.1 1.8 2.1 2.5 2.5 2.6 2.2 -2.5 -2.0 0.9 -0.2
Past tobacco smoking 0.7 1.4 3.7 0.6 -0.7 -1.7 -1.9 -0.7 -1.1 -0.1 1.2 0.3 -1.8 -0.8
Alcohol usually taken with meals 0.4 0.6 3.3 -0.6 0.2 0.5 -1.0 -0.7 -0.7 -0.4 -0.5 0.1 1.8 0.7
Nervous feelings 1.0 1.8 3.7 -1.6 -1.6 -0.1 -0.3 -1.3 -1.7 -1.6 1.2 1.9 1.1 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.6 -1.2 -0.5 -0.7 -0.3 -1.0 -0.7 -1.1 0.8 0.9 0.8 0.4
Hearing difficulty/problems with background noise 1.5 2.4 5.9 0.3 2.4 -1.4 0.5 1.1 2.1 1.1 0.0 -2.3 0.1 -2.4
Hair/balding pattern: Pattern 2 0.9 1.1 3.3 -1.3 -0.9 -1.0 -0.2 -1.0 -1.4 -1.1 1.8 0.9 -0.2 0.3
Had menopause 0.3 0.4 1.7 -0.6 -0.7 1.3 0.9 0.1 -0.0 0.0 -0.1 0.3 0.7 0.4
Had other major operations 0.3 0.4 1.3 0.4 0.4 0.2 -0.0 0.0 0.0 0.5 0.3 -0.8 -1.1 -1.1
Forced vital capacity (FVC) 1.2 4.4 11.0 3.3 2.6 -0.8 0.1 2.1 2.5 2.3 -2.6 -2.4 -0.4 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 5.1 1.6 1.8 2.0 1.5 1.7 2.0 1.8 -1.4 -2.3 -0.3 -1.4
Ever unenthusiastic/disinterested for a whole week 2.3 2.8 5.9 2.0 2.2 0.8 0.3 1.5 2.0 1.8 -1.5 -2.4 -0.7 -1.6
Qualifications: None of the above 0.2 0.4 1.7 -1.3 -0.5 -0.3 -0.3 -0.6 -0.3 -0.6 1.2 0.1 0.3 -0.4
Financial difficulties in last 2 years 2.1 2.9 5.9 -2.3 -0.9 -1.3 -1.7 -1.8 -1.3 -2.2 1.0 1.4 2.4 1.6
Mouth/teeth dental problems 2.1 3.3 8.8 3.0 1.4 -1.1 -0.0 1.7 1.6 1.8 -1.2 -2.0 -2.3 -2.3
Heart attack 0.3 0.4 0.9 -0.9 -0.1 0.9 -0.7 -0.7 -0.4 -0.8 0.2 0.4 1.0 0.7
Allergy 0.7 1.5 3.8 -1.5 -0.4 -1.3 -0.9 -1.2 -1.9 -0.7 1.5 1.3 0.9 1.1
Pain all over the body in last month 1.5 1.6 10.3 0.2 1.0 3.2 1.7 0.8 0.8 1.0 -0.7 -0.8 -0.2 -0.3
Diabetes (self-reported) 0.3 0.4 1.3 0.7 -0.3 1.1 0.6 0.4 1.0 0.1 -1.0 -0.1 -0.3 0.1
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 2.2 0.3 -0.3 -1.2 -1.4 -0.7 -0.8 -0.8 1.4 0.3 -1.5 -1.0
Medication: Ramipril 1.5 1.9 3.7 -1.5 -0.9 -1.0 -1.4 -1.6 -1.9 -1.5 1.0 1.4 1.5 1.1
Medication: Simvastatin 0.4 0.6 3.3 -1.8 -0.3 0.2 -0.2 -0.6 -0.3 -0.8 0.5 0.5 1.4 0.1
Fluid intelligence score 0.5 1.1 3.4 0.5 0.1 -1.8 -1.5 -0.6 -0.4 -0.1 1.8 -0.3 -0.6 -1.3
Illnesses of siblings 3.2 4.5 7.2 2.1 2.6 0.8 2.0 2.4 1.9 2.7 -1.0 -2.4 -1.8 -2.5
Neuroticism score 2.3 4.8 8.2 -2.9 -2.4 -1.2 -2.1 -2.2 -2.1 -2.6 2.5 2.7 1.0 1.5
Weight 0.3 1.5 7.4 1.3 0.3 1.6 0.2 0.2 1.2 0.3 -2.7 -0.7 1.3 1.1
Impedance of arm (right) 0.9 4.0 8.0 -0.4 -2.8 -2.1 -1.9 -1.3 -2.3 -1.6 2.4 2.4 -2.6 -0.0
Arm fat percentage (right) 0.2 0.7 1.4 0.1 -1.2 1.1 -0.2 -0.7 -0.1 -1.1 -1.1 0.6 1.0 1.1
Trunk fat-free mass 1.4 8.0 22.3 3.1 3.2 2.0 1.5 2.6 3.6 3.0 -4.7 -3.0 1.3 0.1
Hip circumference 0.2 0.9 2.8 0.4 -0.7 1.2 0.1 -0.6 0.1 -0.7 -1.7 0.3 1.3 1.5
Time employed in main current job 0.1 0.2 0.4 0.6 0.3 0.3 -0.1 0.1 0.0 -0.1 -0.6 -0.1 0.7 0.6
Alcohol intake versus 10 years previously 1.5 2.3 5.3 -0.9 -1.4 -1.1 -1.5 -1.4 -0.9 -1.8 -0.0 1.5 2.3 2.3
Father’s age at death 3.6 4.8 7.9 2.3 2.6 0.9 1.2 2.6 2.4 2.8 -2.2 -2.8 -1.1 -2.1
Worrier / anxious feelings 2.4 4.6 7.9 -2.4 -2.3 -0.9 -1.6 -2.5 -2.7 -2.5 2.4 2.8 0.3 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.7 -1.3 -0.3 -0.6 -1.1 -1.2 -0.3 -1.3 0.6 0.8 1.6 1.0
Falls in the last year 0.9 1.2 3.3 -1.8 -0.6 -1.6 -0.5 -0.9 -1.2 -0.6 1.6 0.9 0.8 0.5
Hair/balding pattern: Pattern 3 0.7 1.1 2.6 -1.6 -0.9 0.8 -1.1 -1.1 -0.6 -1.4 0.0 1.1 1.1 0.9
Number of live births 3.1 4.4 9.8 1.9 1.5 3.1 2.6 2.2 2.4 1.8 -1.5 -2.5 -0.8 -1.9
Forced expiratory volume in 1-second (FEV1) 1.3 4.5 12.2 3.5 2.5 -0.9 -0.1 2.0 2.3 2.3 -2.5 -2.5 -0.8 -1.4
Pulse rate 0.3 0.4 1.7 0.3 0.9 0.4 -0.2 0.4 0.0 0.5 -1.1 -0.5 1.3 0.2
Happiness 0.2 0.3 0.8 0.5 0.2 0.4 0.3 0.4 0.7 0.0 -0.0 -0.3 -0.8 -0.9
Noisy workplace 0.3 0.4 1.2 0.7 0.5 0.7 0.4 0.4 0.6 0.5 -1.1 0.1 0.2 1.0
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.2 1.1 0.9 -0.9 -0.4 0.4 0.2 0.9 -0.5 -0.9 -0.7 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 -0.0 -0.3 0.3 -0.1 0.3 0.5 0.3 -0.0 -0.2 0.3 -0.1
Mouth/teeth dental problems: Dentures 0.4 0.7 2.8 -0.5 -0.4 1.1 0.1 -0.2 -0.0 -0.4 -0.6 0.6 1.7 1.4
Asthma 2.3 4.6 9.7 1.7 1.2 3.1 2.4 2.6 2.3 2.1 -1.4 -1.9 -2.2 -1.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.9 -0.5 0.8 -1.0 1.0 0.7 0.6 0.6 0.6 -0.9 -1.7 -1.3
Medication: Cholesterol lowering 0.5 0.7 3.1 -1.3 -0.3 0.6 -0.6 -0.8 -0.3 -0.9 -0.2 0.6 1.8 0.8
Depression (self-reported) 1.0 1.2 5.6 -0.4 -0.3 -0.4 -2.4 -1.3 -1.2 -1.1 1.2 0.8 0.2 -0.0
Medication: Lansoprazole 0.6 0.6 2.9 0.3 -0.1 1.7 0.8 0.7 0.8 0.3 -1.0 -0.1 0.9 0.4
Prospective memory result 0.1 0.2 0.6 0.2 0.3 0.6 -0.8 0.0 -0.3 0.1 -0.5 -0.0 0.5 0.2
Lung cancer (father) 1.2 1.4 5.0 -0.0 1.2 1.8 2.2 1.1 1.3 1.2 -0.0 -1.0 -0.5 -0.6
Illnesses of mother 0.5 0.6 2.0 0.7 0.2 0.0 0.8 0.6 0.7 0.6 -0.7 -1.0 -1.4 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.5 17.0 4.1 3.7 -0.7 1.0 3.3 3.6 3.7 -2.9 -3.9 -1.7 -2.8
Pulse wave Arterial Stiffness index 1.5 1.7 3.1 -0.5 -1.6 0.8 -0.5 -1.4 -1.5 -1.5 -0.5 1.7 1.5 1.7
Impedance of arm (left) 0.8 3.8 7.9 -0.1 -2.7 -2.0 -1.7 -1.1 -2.3 -1.3 2.5 2.2 -2.8 -0.3
Arm fat mass (right) 0.2 0.9 3.7 0.5 -0.4 1.4 0.0 -0.3 0.6 -0.5 -1.9 -0.1 1.4 1.2
Trunk predicted mass 1.4 7.9 22.0 3.1 3.2 2.0 1.5 2.5 3.6 2.9 -4.7 -3.0 1.4 0.1
Standing height 0.4 3.5 14.6 3.8 1.1 -0.0 -0.5 1.5 1.8 2.2 -3.0 -1.2 -1.3 -0.0
Length of working week for main job 0.4 0.5 1.6 0.6 0.4 0.9 0.3 0.8 0.8 0.4 0.0 -0.7 -0.5 -1.3
Exposure to tobacco smoke at home 0.4 0.4 1.0 -0.3 -0.5 -0.5 -0.7 -0.6 -0.4 -0.6 -0.3 0.6 1.0 1.0
Breastfed as a baby 1.6 1.9 3.7 1.9 1.7 1.2 0.8 1.4 1.2 1.6 -1.7 -1.6 -0.6 -0.9
Tense / ‘highly strung’ 1.5 2.4 4.8 -2.2 -1.3 -0.5 -0.4 -1.5 -1.9 -1.8 1.3 2.0 1.5 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 2.8 -1.2 -1.6 0.7 -0.9 -1.3 -0.9 -1.7 0.8 1.5 1.5 1.4
Hair/balding pattern: Pattern 4 0.2 0.6 3.1 1.8 0.2 -0.0 -0.1 0.1 0.6 0.9 -1.3 -0.2 0.3 0.6
Birth weight of first child 1.7 3.1 9.9 3.1 1.6 0.8 0.7 1.6 2.1 2.0 -2.0 -1.8 -1.0 -0.9
Peak expiratory flow (PEF) 1.8 4.3 8.5 2.9 2.6 0.1 0.1 1.9 2.3 2.5 -2.2 -2.8 -0.6 -1.9
Pulse wave reflection index 2.9 3.6 7.2 -1.1 -2.7 -1.1 -1.8 -2.5 -2.2 -2.4 1.2 2.5 0.2 1.6
Ever highly irritable/argumentative for 2 days 1.1 1.4 4.7 -1.9 -0.5 -0.7 -1.2 -1.4 -1.0 -0.9 2.2 0.6 -0.2 -0.3
Loud music exposure frequency 0.5 0.6 2.4 -0.7 -0.1 0.6 0.0 -0.7 -0.7 -0.3 0.1 0.7 1.6 1.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.8 -0.1 -0.4 -0.1 -0.5 -0.1 -0.5 -0.3 0.2 0.1 -0.9 -0.4
Mouth/teeth dental problems: Bleeding gums 2.7 3.5 12.0 -3.5 -1.4 0.9 0.5 -1.4 -1.9 -1.6 1.7 2.0 1.7 2.3
Blood clot in the leg (DVT) 0.2 0.2 1.7 -0.1 0.1 1.3 0.4 -0.4 -0.5 -0.0 -0.2 -0.1 -0.2 0.4
Medication: Paracetamol 0.2 0.3 1.7 -0.5 0.2 -0.1 -0.1 0.3 -0.4 -0.1 0.2 0.4 1.3 1.0
Headache pain in last month 0.2 0.3 1.1 -0.5 0.2 -0.4 1.0 0.4 -0.2 0.3 0.8 -0.1 -0.5 -0.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.3 1.3 0.6 -0.6 0.4 0.7 0.7 1.0 -0.1 -1.0 -1.5 -0.7
Glaucoma (self-reported) 0.4 0.4 1.5 0.5 0.0 0.7 1.2 0.6 0.8 0.7 -0.6 -0.7 0.5 0.1
Gout (self-reported) 0.2 0.2 1.2 0.6 0.4 -0.5 0.2 0.2 -0.3 0.1 -1.1 -0.0 0.3 0.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.8 -1.1 0.3 0.2 -0.5 -0.5 -0.2 -0.3 0.5 0.2 1.3 0.3
Medication: Amlodipine 1.2 1.6 3.6 -1.9 -1.0 -0.2 -0.7 -1.4 -1.4 -1.7 0.5 1.3 1.4 1.4
Medication: Ventolin 100micrograms inhaler 0.8 1.0 3.8 1.4 -0.4 0.5 0.9 1.0 1.0 0.6 -0.6 -0.3 -1.9 -0.9
Birth weight 1.7 3.7 13.5 3.7 1.2 -1.3 -0.2 1.6 2.0 1.9 -2.2 -1.8 -2.0 -1.1
Chronic bronchitis/emphysema (mother) 0.8 1.0 3.6 -1.0 -0.9 -0.4 -1.0 -1.1 -1.1 -1.0 1.9 0.7 -0.3 -0.2
High blood pressure (siblings) 0.8 1.2 2.2 -1.2 -1.5 -0.9 -1.1 -1.2 -0.8 -1.5 1.0 1.1 0.3 0.9
Forced vital capacity (FVC), Best measure 2.4 8.6 14.9 3.9 3.6 -0.9 0.9 3.2 3.6 3.5 -2.7 -3.6 -1.6 -2.7
Body fat percentage 0.5 1.8 3.8 -0.7 -2.0 1.1 -0.7 -1.7 -1.1 -1.9 -0.2 1.5 1.1 1.6
Leg fat percentage (right) 0.7 2.6 5.1 -2.0 -2.0 1.1 -0.3 -1.8 -1.4 -2.3 0.2 1.8 1.8 1.7
Arm fat-free mass (right) 1.3 6.6 16.9 2.6 3.1 2.4 1.5 2.1 3.2 2.6 -4.1 -2.9 1.3 -0.0
Exposure to tobacco smoke outside home 0.4 0.5 1.0 -0.4 0.9 0.2 0.9 0.6 0.9 0.6 -1.0 -0.7 0.9 -0.2
Comparative body size at age 10 0.7 2.1 3.6 1.7 1.3 1.3 1.9 1.8 1.3 1.9 -1.2 -1.4 -0.6 -0.8
Number of full brothers 1.0 1.2 2.6 -0.8 -1.3 -0.6 -1.1 -1.5 -0.8 -1.6 0.7 1.2 1.3 0.8
Worry too long after embarrassment 3.0 5.1 14.1 -1.2 -2.2 -2.2 -3.8 -2.7 -2.3 -2.3 1.6 2.4 1.1 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.4 0.9 0.7 1.6 0.9 1.0 0.8 1.2 -0.2 -0.9 -1.3 -0.9
Wheeze or whistling in the chest in last year 0.6 1.2 2.5 -1.6 -1.3 1.0 1.4 -0.4 -0.8 -1.1 1.2 1.2 -0.6 0.5
Number of children fathered 0.5 0.6 2.9 -0.4 -0.9 -0.0 1.2 0.8 0.2 0.3 0.3 0.6 -1.7 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.0 0.1 0.4 -1.0 -0.1 0.2 0.6 0.2 0.3 -0.4 -0.2 -0.7
Age at first live birth 0.3 0.6 1.5 0.9 0.6 0.8 1.0 1.0 -0.2 1.2 -0.5 -0.1 -1.0 0.1
Pulse wave peak to peak time 1.8 2.1 3.5 0.8 1.7 -0.6 0.7 1.7 1.7 1.8 0.3 -1.9 -1.7 -1.8
Health satisfaction 0.6 0.8 2.8 -1.7 0.1 -0.3 -0.6 -1.0 -0.5 -0.9 0.9 0.6 1.3 0.2
Shortness of breath walking on level ground 0.1 0.1 0.2 -0.4 -0.0 -0.5 0.4 0.2 0.5 -0.3 -0.2 0.2 0.2 -0.3
Qualifications: College or University degree 1.5 4.8 11.1 3.3 2.4 0.3 0.9 2.5 2.3 2.6 -1.9 -2.4 -1.9 -2.2
Eye problems/disorders: None of the above 0.7 0.8 2.0 -1.4 0.2 -1.4 -1.2 -0.5 -0.5 -1.0 0.8 0.4 0.8 0.5
Mouth/teeth dental problems: Loose teeth 1.1 1.3 5.9 -1.5 0.2 -1.8 -0.0 -0.1 -0.7 -0.3 2.4 0.1 -0.8 -1.5
Emphysema/chronic bronchitis 0.9 1.0 6.2 -1.3 -0.2 1.6 2.5 0.8 0.2 0.1 0.3 0.4 -0.1 0.3
Medication for pain relief, constipation, heartburn 0.3 0.5 2.2 1.3 -0.8 -0.8 0.0 0.3 0.3 0.4 -0.4 0.1 -1.5 -0.6
Neck or shoulder pain in last month 0.7 1.1 3.1 0.2 0.8 1.8 1.8 0.9 0.5 0.8 -0.9 -0.9 1.2 0.4
Medication: Blood pressure 0.5 0.9 3.2 -1.4 -0.3 0.1 -0.9 -0.8 -0.8 -0.9 0.4 0.9 1.8 0.8
Angina (self-reported) 1.7 2.2 3.8 -1.8 -1.6 0.9 -0.9 -1.6 -1.9 -1.6 1.5 1.9 0.7 1.4
Migraine (self-reported) 0.6 0.8 4.4 0.1 -0.2 -2.1 -1.1 -0.5 -1.2 -0.2 0.7 0.8 -0.1 0.3
Medication: Ibuprofen 0.6 0.7 1.4 -0.0 1.1 -0.8 0.9 0.8 1.0 0.7 -0.2 -1.2 -0.9 -0.9
Medication: Allopurinol 0.5 0.6 2.7 0.8 0.6 -0.6 0.8 0.6 0.3 0.4 -1.6 -0.5 0.8 0.9
Medication: Omeprazole 0.8 1.0 7.2 -1.0 0.0 0.4 -0.5 -0.8 0.1 -0.8 -0.3 0.4 2.7 1.1
Medication: Seretide 50 evohaler 1.4 1.7 10.2 -1.3 0.2 3.2 1.5 0.7 0.8 0.0 0.0 -0.2 1.7 -0.3
Mean time to correctly identify matches 0.9 1.7 4.3 -1.3 -1.6 0.6 -0.6 -1.6 -1.5 -2.1 1.1 1.5 -0.3 0.8
Heart disease (mother) 0.9 1.1 4.8 -1.1 -0.2 -0.6 -0.7 -0.3 -0.1 -0.8 -0.5 0.6 2.2 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 4.0 -1.8 -1.6 0.3 -0.2 -1.1 -1.4 -1.6 0.4 2.0 0.8 1.8
Whole body fat mass 0.2 1.0 2.1 0.1 -0.9 1.3 -0.4 -0.9 -0.2 -1.0 -1.5 0.6 1.4 1.5
Leg fat mass (right) 0.2 0.9 2.4 -0.4 -0.8 1.1 -0.2 -0.8 -0.2 -1.1 -1.1 0.6 1.5 1.4
Arm predicted mass (right) 1.2 6.2 16.6 2.7 2.8 2.3 1.5 2.1 3.0 2.6 -4.1 -2.7 1.1 0.2
Pulse rate, automated reading 2.6 8.4 15.3 -2.3 -3.7 -1.8 -2.5 -3.2 -3.7 -3.1 2.2 3.9 1.1 2.9
Alcohol intake frequency. 0.4 1.0 5.3 -0.8 0.5 -0.6 -0.8 -0.4 -0.5 -0.6 -0.6 0.3 2.3 1.5
Comparative height size at age 10 0.6 3.6 12.3 3.5 1.0 1.8 0.7 1.7 1.7 2.6 -2.6 -1.4 -0.9 0.2
Number of full sisters 0.5 0.6 1.4 1.2 0.9 0.2 0.4 1.1 0.7 0.8 -1.1 -0.6 -0.3 -0.2
Suffer from ‘nerves’ 2.6 4.0 7.1 -2.3 -1.6 -1.6 -2.3 -2.3 -1.9 -2.7 1.9 1.8 1.8 1.4
Overall health rating 2.0 4.4 12.1 -3.5 -1.6 -0.1 -0.4 -2.2 -1.7 -2.6 1.7 2.2 2.9 1.8
Chest pain or discomfort 1.9 2.7 9.2 -3.0 -1.2 -1.3 -0.5 -1.8 -1.5 -1.8 2.4 1.4 0.9 0.4
Had major operations 1.7 1.9 6.8 -0.9 0.2 2.2 2.6 1.4 1.2 0.8 -0.7 -0.1 1.9 0.5
Age at last live birth 0.9 1.3 4.4 0.9 1.1 2.1 1.4 1.4 0.2 1.5 -1.0 -0.7 0.2 0.4
Family relationship satisfaction 0.8 1.0 4.4 -0.7 0.4 -0.4 -1.8 -1.1 0.1 -0.8 -0.3 0.1 2.1 0.6
Leg pain on walking 0.6 0.8 4.0 -0.2 0.1 2.0 1.0 0.9 0.9 0.7 -0.8 -0.6 0.7 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 7.5 0.2 -0.6 2.7 0.6 0.1 0.2 -0.6 -1.1 0.5 0.4 1.3
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.4 -1.0 -0.8 -0.1 -1.0 -1.1 -0.8 -1.5 0.1 1.3 1.4 1.5
Illness, injury, bereavement, stress in last 2 years 2.8 3.5 9.7 1.2 1.7 0.3 1.8 1.8 1.5 2.1 0.0 -2.0 -2.6 -3.1
Medication: Aspirin 1.3 1.7 3.4 -1.4 -0.5 0.4 -1.7 -1.8 -1.7 -1.6 0.9 1.3 1.2 1.1
Supplements: Vitamin C 1.2 1.4 8.4 0.7 0.6 -0.2 0.9 1.1 0.3 1.0 0.6 -0.6 -2.9 -1.4
Knee pain experienced in last month 0.9 1.4 3.5 -1.9 -1.0 -0.9 -1.2 -1.3 -1.1 -1.5 1.5 0.9 1.0 0.3
Hypertension (Self-reported) 1.7 4.7 7.0 -2.6 -2.1 -0.6 -1.8 -2.4 -2.6 -2.6 1.3 2.5 2.1 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.0 -0.7 -0.6 1.0 0.5 -0.3 -0.4 -0.8 0.8 1.0 -0.0 0.1
Illnesses of father: Heart disease 5.1 7.1 11.2 -3.0 -2.6 -2.9 -2.3 -2.8 -3.0 -2.7 3.4 3.2 0.3 1.5
Illnesses of siblings: Diabetes 1.3 1.7 3.8 -0.6 -1.3 0.1 -1.4 -1.9 -0.8 -1.3 0.4 1.3 1.9 1.6
Smoking status: Previous 1.1 1.6 4.9 0.3 0.8 2.2 1.7 0.8 1.2 0.3 -1.8 -0.6 1.5 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 3.3 1.8 0.1 -0.8 -0.4 0.4 0.5 0.7 -0.6 -0.3 -1.4 -0.7
Whole body fat-free mass 1.2 7.1 22.3 3.2 2.7 2.2 1.2 2.3 3.2 2.6 -4.7 -2.7 1.2 0.4
Leg fat-free mass (right) 1.0 5.4 19.4 3.3 2.0 1.9 0.6 1.8 2.7 2.1 -4.4 -2.2 1.0 0.7
Arm fat percentage (left) 0.1 0.6 1.4 0.1 -1.1 1.2 0.1 -0.5 0.0 -0.9 -1.0 0.4 0.7 0.9
Average weekly red wine intake 1.2 1.7 4.1 1.3 1.0 0.3 1.1 1.6 1.0 1.5 0.1 -1.4 -1.8 -2.0
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.2 -0.6 -0.4 0.3 -0.2 -0.4 -0.7 -0.6 0.1 0.6 0.6 1.1
Mood swings 0.7 1.3 4.0 -2.0 -1.2 0.3 -0.2 -0.9 -0.9 -1.6 1.3 1.4 0.3 0.6
Loneliness, isolation 0.6 0.9 2.8 -1.7 -0.5 -0.4 -1.1 -0.9 -1.2 -1.1 1.0 0.6 0.4 0.1
Long-standing illness, disability or infirmity 0.7 1.1 5.4 -0.7 0.6 0.8 -0.3 -0.6 -0.5 -0.4 -1.1 0.4 2.3 1.6
Ever had bowel cancer screening 1.7 2.0 8.8 -1.0 -0.9 1.4 -0.3 -0.9 -0.9 -1.1 -1.0 1.4 3.0 1.9
Diabetes diagnosed by doctor 0.1 0.1 0.3 -0.1 -0.6 0.5 0.4 0.0 0.3 -0.2 -0.1 0.2 -0.5 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.8 0.6 1.3 -0.2 0.2 0.8 0.8 0.9 0.4 -1.1 -0.3 -1.3
Friendships satisfaction 0.5 0.6 1.3 0.8 1.1 -0.9 -0.1 0.4 0.9 0.5 -0.2 -0.9 -0.0 -1.2
Qualifications: nursing, teaching 2.7 4.2 8.0 2.2 2.5 0.8 1.4 2.2 1.9 2.5 -1.6 -2.8 -0.9 -2.4
Commuting to job workplace: Walk 0.1 0.2 0.6 0.2 0.2 -0.8 -0.2 0.2 0.6 0.3 -0.3 -0.5 0.0 -0.2
Eye problems/disorders: Cataract 1.3 1.5 4.5 1.1 0.6 2.1 1.5 1.3 0.8 1.4 -1.8 -0.8 0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.8 -0.4 -1.4 -0.3 -1.1 -1.2 -0.9 -1.0 0.3 1.3 0.2 1.2
Medication for cholesterol 0.4 0.6 0.9 0.6 0.8 0.9 0.7 0.9 1.0 0.9 -0.7 -0.8 -0.6 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.9 0.6 1.2 0.6 1.7 1.7 1.6 1.5 -0.4 -1.5 -0.7 -0.6
Back pain experienced in last month 0.2 0.4 1.0 -0.7 -0.0 -0.6 -0.7 -0.5 -0.2 -0.7 0.1 0.1 1.0 0.8
Mineral and other dietary supplements 0.8 1.0 4.6 -0.4 -0.5 -2.1 0.5 0.4 0.4 0.2 1.5 -0.1 -1.3 -1.3
Breast cancer (self-reported) 0.4 0.5 1.1 -0.6 0.8 -0.5 0.7 0.6 0.6 0.4 0.4 -0.8 1.1 -1.0
Asthma (self-reported) 2.1 4.3 9.9 1.5 1.2 3.1 2.4 2.5 2.3 2.0 -1.5 -1.9 -1.8 -1.7
Osteoporosis (self-reported) 1.1 1.3 3.2 0.0 -1.8 1.3 -0.7 -0.9 0.3 -0.9 -1.2 0.7 1.6 1.7
Osteoarthritis (self-reported) 0.1 0.2 0.8 0.0 0.5 0.6 0.2 0.1 0.1 0.7 0.3 -0.1 0.9 0.0
Medication: Aspirin 1.7 2.2 4.0 -1.7 -0.6 0.6 -1.7 -2.0 -1.8 -1.9 0.9 1.3 1.7 1.1
Medication: Gliclazide 0.4 0.4 1.4 -0.6 -0.7 1.2 0.6 -0.3 -0.6 -0.5 1.0 0.6 -0.3 0.1
Illnesses of father: None of the above (group 1) 0.6 0.7 2.7 1.6 -0.5 0.5 -1.0 0.0 0.4 0.0 -1.7 -0.2 0.2 0.8
Smoking status: Current 0.4 0.7 2.9 -1.3 -0.4 -1.1 -0.4 -0.5 -0.4 -0.7 1.7 0.4 -0.1 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.4 10.6 2.2 3.3 0.7 1.7 2.8 2.7 2.8 -2.2 -3.1 -0.1 -1.9
Whole body water mass 1.3 7.4 22.5 3.3 2.9 2.2 1.3 2.3 3.3 2.7 -4.7 -2.8 1.1 0.3
Leg predicted mass (right) 1.0 5.6 19.9 3.4 2.1 2.0 0.7 1.8 2.8 2.2 -4.5 -2.2 1.0 0.7
Arm fat mass (left) 0.2 0.9 3.7 0.6 -0.2 1.6 0.3 -0.0 0.9 -0.2 -1.9 -0.3 1.2 0.8
Number of self-reported non-cancer illnesses 2.0 3.4 6.4 -1.9 -1.5 0.5 -1.4 -2.1 -2.3 -2.2 0.3 2.1 2.5 2.1
Average weekly champagne plus white wine intake 0.2 0.3 1.7 0.2 -0.5 1.3 0.2 0.3 -0.1 0.1 -0.6 -0.2 -0.5 0.3
Miserableness 2.2 3.7 6.0 -2.2 -2.0 -1.3 -1.8 -1.9 -2.2 -2.1 2.2 2.4 0.8 1.6
Guilty feelings 0.6 0.8 2.1 -0.5 -1.1 -1.0 -1.4 -0.7 -0.6 -0.7 -0.0 1.3 0.5 1.2
Wears glasses or contact lenses 0.4 0.4 1.3 -0.5 -1.1 -0.0 -0.6 -0.5 -0.2 -0.2 1.1 0.5 0.8 0.1
Ever taken oral contraceptive pill 4.0 4.5 9.4 1.8 1.6 0.6 2.6 2.5 2.7 1.8 -1.2 -2.0 -2.2 -3.1
Hearing aid user 0.9 1.1 6.8 -0.3 0.7 1.0 2.6 1.1 0.4 1.0 -0.5 -0.6 0.1 -0.7
Mother’s age at death 0.2 0.2 0.8 -0.1 0.4 -0.2 -0.9 -0.7 -0.5 -0.2 0.4 0.1 0.6 -0.6
Financial situation satisfaction 0.1 0.2 0.6 -0.7 0.5 -0.2 -0.2 -0.2 0.1 -0.2 0.6 -0.2 0.5 -0.6
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.0 -0.6 0.7 -0.1 0.5 0.2 1.0 0.1 -0.1 -0.5 0.8 -0.5
Commuting to job workplace: Public transport 1.0 1.1 4.1 0.4 0.8 0.1 1.3 1.0 0.7 1.3 0.3 -1.2 -1.1 -2.0
Eye problems/disorders: Glaucoma 0.4 0.4 1.1 0.3 0.5 0.5 1.1 0.4 0.8 0.8 0.1 -1.0 0.0 -0.8
Medication: Blood pressure 0.8 1.5 3.1 -0.9 -1.0 -0.8 -1.1 -1.5 -1.6 -1.2 0.2 1.1 1.7 1.5
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.7 -0.3 -1.3 -1.1 -1.1 -0.8 -0.5 -0.7 -0.0 1.1 0.9 1.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.0 -0.4 -1.0 0.6 -0.8 -1.1 -1.3 -1.0 0.2 1.3 0.1 1.4
High cholesterol (Self-reported) 0.7 1.2 6.4 -2.5 0.2 0.4 -0.1 -0.8 -0.7 -0.7 1.2 0.6 1.7 0.5
Medication: Bendroflumethiazide 1.7 2.7 6.0 -1.3 -1.8 -1.1 -2.2 -1.9 -1.5 -2.5 0.4 1.5 1.5 1.4
Medication: Paracetamol 0.4 0.7 3.2 -0.1 0.2 0.5 0.2 0.5 0.3 0.2 -0.9 0.2 1.8 1.7
Medication: Lisinopril 0.6 0.8 2.2 -1.1 1.1 1.5 1.5 0.6 0.4 0.2 0.7 -0.5 0.6 -0.5
Medication: Atorvastatin 0.8 1.0 2.3 0.7 0.9 1.5 1.3 1.0 0.9 0.9 -1.3 -1.0 0.0 0.1
Illnesses of father: High blood pressure 1.2 1.5 6.0 -1.6 -0.6 -2.5 0.5 -0.5 -1.2 -0.4 2.1 0.8 -0.8 -0.2
Alcohol drinker status: Never 0.8 0.9 2.7 -0.2 0.4 1.6 0.7 0.3 1.2 -0.4 -1.6 -0.7 1.6 0.2
Ever smoked 0.3 0.6 2.7 -1.1 0.2 0.6 0.9 0.1 0.5 -0.5 -0.5 0.2 1.7 0.9
Basal metabolic rate 1.0 5.3 18.2 2.8 2.2 1.9 1.0 1.8 2.8 2.1 -4.3 -2.2 1.3 0.6
Leg fat percentage (left) 0.7 2.7 4.7 -1.9 -1.8 1.3 -0.3 -1.9 -1.4 -2.2 0.2 1.7 2.0 1.7
Arm fat-free mass (left) 0.9 4.6 14.8 2.1 2.3 2.1 0.9 1.5 2.6 1.9 -3.8 -2.1 1.7 0.7
Number of operations (self-reported) 0.4 0.6 3.3 -1.3 -0.1 1.1 0.6 0.1 0.1 -0.3 0.1 0.2 1.8 0.2
Average weekly beer plus cider intake 1.1 1.5 3.8 1.7 0.7 1.2 0.9 1.2 1.9 1.1 -1.5 -1.2 -0.9 -0.8
Irritability 2.3 3.8 7.8 -2.8 -2.0 -1.8 -1.3 -1.9 -2.1 -2.4 1.9 2.4 1.1 1.1
Risk taking 0.3 0.4 1.4 0.3 0.5 -0.6 -0.9 -0.1 0.6 0.6 -1.2 -0.9 0.4 -0.1
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.6 1.1 0.3 0.3 0.8 1.0 1.0 0.9 -1.3 -0.8 -0.4 -0.8
Fractured/broken bones in last 5 years 1.9 2.4 4.3 0.8 1.8 0.8 1.8 1.9 2.0 2.1 -1.4 -2.0 -0.4 -1.0
Age started oral contraceptive pill 0.6 0.8 2.2 -0.1 -1.4 -0.1 -0.7 -0.5 -1.5 -0.7 0.3 1.5 -0.7 0.7
Diastolic blood pressure, automated reading 1.0 3.1 7.0 -0.8 -2.6 -0.7 -1.3 -1.9 -2.6 -1.2 1.8 2.4 -0.6 1.8
Ever depressed for a whole week 3.2 3.9 7.4 2.0 2.6 1.2 0.9 1.7 2.3 2.4 -1.0 -2.7 -1.8 -2.1
Unable to work because of sickness or disability 0.3 0.4 1.8 -0.7 0.0 0.7 0.2 -0.2 -0.3 0.3 0.4 0.4 1.3 0.9
Commuting to job workplace: Cycle 1.8 2.2 4.2 1.4 2.1 -0.1 0.8 1.8 1.7 1.9 -1.8 -1.9 -0.5 -0.6
Myopia 2.3 3.3 5.6 -0.7 -2.2 -1.2 -2.3 -2.4 -1.9 -2.2 1.1 2.2 1.1 1.9
Vascular/heart problems diagnosed by doctor 1.8 4.9 7.3 2.5 2.1 0.7 2.1 2.6 2.7 2.6 -1.6 -2.6 -1.9 -2.1
Cholesterol lowering medication 0.2 0.3 1.3 -1.2 -0.4 0.8 0.0 -0.4 -0.5 -0.4 0.9 0.3 -0.3 -0.1
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 8.3 -0.9 -0.6 0.6 -0.8 -1.1 -0.3 -0.9 -0.5 0.8 2.9 1.7
Pain experienced in last month 0.2 0.4 1.3 0.7 -0.3 -0.4 -0.5 0.1 0.6 -0.2 0.0 -0.1 -1.1 -1.1
Supplements: Calcium 0.5 0.6 1.6 -0.6 0.7 -1.2 -1.3 -0.6 -0.5 -0.6 0.5 -0.4 0.8 -0.4
Basal cell carcinoma (self-reported) 0.7 0.9 3.8 1.0 -0.5 1.9 1.2 0.8 -0.2 0.5 -0.9 0.1 -0.9 0.7
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.3 -1.1 -0.4 0.6 -0.8 -0.9 -0.7 -1.1 0.4 0.7 1.0 0.8
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.5 0.3 0.6 1.6 1.0 0.2 0.0 0.5 -0.4 -0.7 -0.7 -0.3
Heart disease (siblings) 4.6 5.6 9.2 -2.1 -2.6 -1.1 -2.6 -2.5 -2.0 -2.8 0.6 2.8 2.6 3.0
Alcohol drinker status: Previous 0.4 0.5 1.5 1.2 0.2 -0.4 -0.5 0.7 -0.6 1.0 -0.4 0.2 -0.3 1.0
Pack years of smoking 3.5 5.1 9.5 -3.1 -2.4 -1.1 -1.6 -2.3 -2.4 -2.5 2.0 2.9 1.7 2.3
Impedance of whole body 1.4 7.0 16.6 -1.6 -3.2 -2.6 -2.2 -2.3 -3.3 -2.2 4.1 3.1 -2.5 -0.1
Leg fat mass (left) 0.2 1.0 3.0 -0.5 -0.7 1.2 -0.2 -1.0 -0.2 -1.0 -1.1 0.5 1.7 1.4
Arm predicted mass (left) 1.0 5.0 15.9 2.1 2.5 2.2 0.9 1.5 2.8 1.9 -4.0 -2.2 1.9 0.7