[Hub]/) : Traits : Blood White Count :

chr19:46,923,752-49,829,825

Best TWAS P=4.48e-18 · Best GWAS P=1.31e-15 conditioned to 0.00413

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NAPA 0.06 0.00 bslmm 381 0.01 7.2e-03 0.92 6.7 2.1e-11 0.47 0.03 0.52 FALSE
2 GTEx Adipose Subcutaneous CCDC9 0.18 0.16 lasso 5 0.16 5.0e-13 7.96 -7.9 2.6e-15 -1.00 0.01 0.99 FALSE
3 GTEx Adipose Visceral Omentum CCDC9 0.19 0.10 enet 11 0.11 3.1e-06 7.97 -6.8 8.5e-12 -0.95 0.01 0.99 FALSE
4 GTEx Artery Tibial CCDC9 0.09 0.03 lasso 5 0.03 3.7e-03 7.97 -7.4 1.5e-13 -0.95 0.01 0.97 FALSE
5 GTEx Brain Caudate basal ganglia KPTN 0.24 -0.01 enet 14 -0.01 7.3e-01 3.46 -7.0 2.6e-12 -0.51 0.02 0.69 FALSE
6 GTEx Brain Frontal Cortex BA9 KPTN 0.26 0.01 lasso 4 0.00 4.1e-01 7.74 -7.5 9.6e-14 -0.95 0.01 0.81 FALSE
7 GTEx Cells EBV-transformed lymphocytes CCDC9 0.32 0.22 enet 15 0.15 1.2e-05 7.99 -7.4 1.4e-13 -0.91 0.01 0.99 FALSE
8 GTEx Cells Transformed fibroblasts CCDC9 0.16 0.13 lasso 3 0.14 2.0e-10 7.97 -7.6 2.2e-14 -0.96 0.01 0.99 FALSE
9 GTEx Esophagus Mucosa CCDC9 0.18 0.13 lasso 3 0.12 2.7e-08 7.99 -7.9 3.1e-15 -1.00 0.01 0.99 FALSE
10 GTEx Esophagus Muscularis CCDC9 0.14 0.11 lasso 3 0.11 3.9e-07 7.99 -6.7 3.0e-11 -0.88 0.01 0.99 FALSE
11 GTEx Heart Atrial Appendage CCDC9 0.20 0.03 enet 21 0.05 2.2e-03 7.99 -5.3 9.1e-08 -0.71 0.01 0.88 FALSE
12 GTEx Nerve Tibial CCDC9 0.28 0.17 enet 23 0.16 1.6e-11 7.99 -6.8 9.5e-12 -0.88 0.01 0.99 FALSE
13 GTEx Skin Sun Exposed Lower leg CCDC9 0.13 0.00 lasso 5 0.00 2.2e-01 7.97 -6.0 1.7e-09 -0.89 0.01 0.93 FALSE
14 GTEx Thyroid CCDC9 0.22 0.09 lasso 4 0.16 3.6e-12 7.97 -5.7 1.5e-08 -0.78 0.01 0.99 FALSE
15 METSIM Adipose SAE1 0.12 0.04 lasso 5 0.07 1.7e-10 4.78 6.7 2.6e-11 0.38 0.99 0.01 FALSE
16 YFS Blood SAE1 0.07 0.02 enet 18 0.05 3.6e-16 6.89 5.2 2.6e-07 0.31 0.97 0.03 FALSE
17 YFS Blood SPHK2 0.07 0.04 enet 6 0.06 4.4e-18 -6.85 -5.8 5.2e-09 0.06 0.00 1.00 FALSE
18 The Cancer Genome Atlas Breast Invasive Carcinoma SEC1 0.05 0.05 enet 5 0.05 2.2e-11 -6.02 6.2 4.8e-10 0.00 0.01 0.99 FALSE
19 The Cancer Genome Atlas Breast Invasive Carcinoma SPACA4 0.02 0.01 blup 59 0.01 1.1e-02 -6.85 5.4 5.3e-08 -0.02 0.00 0.80 FALSE
20 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCDC9 0.09 0.00 enet 12 0.03 7.9e-03 5.31 -8.7 4.5e-18 -0.65 0.01 0.77 TRUE
21 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma DBP 0.09 0.01 blup 50 0.03 1.1e-02 -6.02 5.9 3.8e-09 -0.04 0.01 0.81 FALSE
22 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCDC9 0.04 0.01 blup 30 0.03 1.2e-04 7.99 -6.0 1.9e-09 -0.85 0.01 0.93 FALSE
23 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEC1 0.14 0.13 lasso 2 0.13 1.6e-14 -6.98 7.1 1.6e-12 -0.04 0.00 1.00 TRUE
24 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SEC1 0.12 0.05 blup 61 0.07 1.1e-04 -6.85 6.1 1.2e-09 -0.04 0.00 0.98 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma SEC1 0.16 0.11 lasso 4 0.11 2.1e-12 -6.85 6.7 1.9e-11 -0.04 0.00 1.00 FALSE
26 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GRLF1 0.04 0.04 blup 51 0.03 7.0e-05 -5.00 -6.0 2.6e-09 -0.08 0.01 0.97 TRUE
27 The Cancer Genome Atlas Prostate Adenocarcinoma CCDC9 0.02 0.03 lasso 7 0.03 2.8e-04 7.97 -8.2 2.1e-16 -0.99 0.01 0.93 FALSE
28 The Cancer Genome Atlas Prostate Adenocarcinoma SEC1 0.06 0.05 enet 2 0.06 1.9e-06 -6.85 7.0 2.4e-12 -0.04 0.00 1.00 FALSE
29 The Cancer Genome Atlas Rectum Adenocarcinoma CCDC9 0.12 0.12 lasso 4 0.10 1.9e-03 7.97 -7.1 1.2e-12 -0.94 0.01 0.73 FALSE
30 The Cancer Genome Atlas Soft Tissue Sarcoma SEC1 0.31 0.17 lasso 6 0.17 1.4e-10 -6.85 7.0 1.9e-12 -0.07 0.00 1.00 FALSE
31 The Cancer Genome Atlas Testicular Germ Cell Tumors PRR24 0.08 -0.01 blup 31 0.02 8.8e-02 7.97 5.8 5.7e-09 0.93 0.01 0.59 FALSE
32 The Cancer Genome Atlas Thyroid Carcinoma SEC1 0.23 0.15 blup 64 0.14 6.7e-14 -6.85 6.3 2.9e-10 -0.01 0.00 1.00 FALSE
33 The Cancer Genome Atlas Thyroid Carcinoma SPHK2 0.06 0.06 lasso 5 0.06 1.0e-06 -6.85 -6.9 6.6e-12 0.04 0.00 1.00 FALSE