Hub : Genes

DBP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Gastroesophageal Junction 0.332 0.108 0.0063 -0.006 NA -0.008 NA -0.002 0.630 NA 0.89 NA 0.400
2 TCGA Cervical Squamous Cell Carcinoma 0.092 0.043 0.0067 0.012 0.031 0.017 NA 0.020 0.083 0.011 0.05 NA 0.034

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.1 0.3 -0.5 0.0
Bipolar Disorder or Schizophrenia 0.0 0.0 0.1 0.3 0.0
Depressed Affect (Nagel 2018) 0.2 0.4 0.7 -0.2 -0.8
Depression (Nagel 2018) 0.1 0.1 0.2 0.3 0.4
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.4 0.1 0.6
Neuroticism (Nagel 2018) 0.4 0.8 1.4 0.5 -1.2
Schizophrenia (2018) 0.0 0.0 0.0 -0.1 0.0
Schizophrenia vs Biploar Disorder 0.8 1.1 2.2 1.5 0.0
Worry (Nagel 2018) 0.6 1.3 1.9 0.9 -1.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.3 0.4
Alzheimer’s Disease (in father) 0.6 0.7 0.7 0.8 0.9
Alzheimer’s Disease (including proxy) 0.3 0.5 0.7 0.5 0.8
Crohns Disease (2017) 1.7 3.8 5.7 -2.4 1.4
Irritable Bowel Disease (IBD) 0.6 1.4 2.2 -1.5 0.8
Ulcerative Colitis (UC) 0.1 0.3 0.3 0.5 0.6
Major Depression (MDD) 0.2 0.2 0.4 -0.6 0.0
Reaction Time 0.2 0.5 0.5 -0.6 -0.7
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.3 -0.3 1.1
Breast Cancer 1.1 2.6 4.2 2.0 -1.0
Ovarian Cancer 1.1 1.5 2.9 -1.7 0.2
Prostate Cancer 0.2 0.2 0.4 0.7 -0.0
Age at First Birth 1.3 1.8 3.3 -0.6 -1.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 -0.8 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.9 1.5 3.0 -1.7 0.0
Mean Putamen Volume 0.8 0.9 1.8 1.3 0.1
Fasting Glucose 0.0 0.0 0.0 0.2 -0.1
HbA1C 1.8 2.0 3.5 -1.9 0.7
HDL Cholesterol 0.0 0.1 0.1 -0.4 0.0
LDL Cholesterol 0.2 0.4 0.8 -0.9 0.0
Lupus 1.1 1.7 3.2 0.4 -1.8
Neuroticism (2016) 0.1 0.1 0.2 0.4 -0.0
Primary Biliary Cirrhosis 1.0 1.4 1.8 0.9 -1.4
Rheumatoid Arthritis 1.0 1.4 2.2 -0.8 -1.5
Schizophrenia (2014) 0.0 0.1 0.2 0.4 0.0
Triglycerides 0.0 0.0 0.0 0.1 0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.6 0.8 1.6 1.3 0.0
Blood Eosinophil Count 0.0 0.0 0.1 -0.1 0.2
Blood Platelet Count 0.8 9.2 18.4 0.3 4.3
Blood Red Count 0.1 1.0 1.5 0.7 -1.2
Blood White Count 2.4 18.1 34.7 1.2 5.9
Heel T-Score 0.2 1.9 2.2 1.5 1.2
BMI 0.7 4.1 5.6 1.6 2.4
Height 0.7 12.7 22.1 -1.8 -4.7
Waist Hip Ratio (WHR) 1.6 7.0 12.0 -1.4 3.5
Systolic Blood Pressure 0.2 1.0 1.7 1.3 -0.5
Smoking Status 0.8 1.9 3.5 0.5 1.9
Allergy or Eczema 0.5 1.2 1.5 -1.2 -0.9
Cardiovascular Disease 0.7 2.2 2.7 1.6 -1.3
Hypothyroidism (self reported) 0.7 1.6 3.2 0.1 1.8
Respiratory disease 0.3 0.7 1.4 0.3 -1.2
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 0.2 0.3
Lung FEV1/FVC ratio 0.1 0.5 1.0 1.0 -0.3
Lung FVC 2.3 11.5 16.6 -2.5 -4.1
Neuroticism 0.7 1.8 3.1 0.7 -1.8
Chronotype (morning person) 0.0 0.0 0.0 -0.0 -0.2
Hair Pigment 0.0 0.6 1.2 0.2 -1.1
Tanning 0.1 0.8 1.0 -0.8 -1.0
Hand grip strength (left) 0.1 0.3 0.4 0.4 -0.6
Number of treatments/medications taken 2.0 3.6 4.3 1.7 -2.1
Average weekly spirits intake 0.7 0.8 1.5 -1.2 -0.5
Sensitivity / hurt feelings 0.6 1.0 1.1 0.9 -1.1
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.7 -0.3 1.3
Hearing difficulty/problems: Yes 3.2 4.8 9.6 0.1 -3.1
Relative age of first facial hair 0.6 1.3 1.9 -0.9 1.4
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.2 -0.7 1.5
Ever used hormone-replacement therapy (HRT) 6.7 8.5 17.1 -0.1 -4.1
Ever had hysterectomy (womb removed) 0.4 0.4 0.9 0.0 -0.9
Systolic blood pressure, automated reading 0.4 1.2 1.9 1.4 0.7
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 -0.2 0.2
Angina 0.8 1.1 2.2 1.5 0.1
Medication for hormone replacement therapy 1.0 1.2 1.6 0.9 -1.3
Vitamin and mineral supplements 2.0 2.7 4.8 0.7 2.2
Supplements: Zinc 1.3 1.4 2.7 -0.1 -1.6
Medication: Co-codamol 0.7 0.8 1.3 1.2 0.5
Medication: Metformin 0.0 0.0 0.0 -0.1 -0.2
Diabetes (father) 0.4 0.5 1.0 1.0 0.1
Diabetes (mother) 1.3 1.7 2.3 1.1 1.5
Severe depression (siblings) 2.6 2.9 4.4 2.1 -1.2
Pack years adult smoking proportion 1.6 2.4 4.8 -0.1 -2.2
Impedance of leg (right) 0.3 1.5 2.5 -1.6 -0.7
Leg fat-free mass (left) 0.1 0.3 0.4 0.6 -0.5
Trunk fat percentage 0.2 1.0 1.1 0.9 1.0
Hand grip strength (right) 0.1 0.3 0.3 -0.5 -0.5
Townsend deprivation index at recruitment 0.1 0.1 0.1 -0.4 0.1
Current tobacco smoking 0.3 0.4 0.5 0.7 0.6
Average weekly fortified wine intake 0.1 0.1 0.2 0.4 0.2
Maternal smoking around birth 0.5 0.7 1.4 0.0 -1.2
Fed-up feelings 0.5 0.9 1.7 0.4 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.7 -0.8 -0.3
Relative age voice broke 1.0 1.6 3.1 0.2 1.8
Taking other prescription medications 1.1 1.8 3.0 1.7 -0.7
Age when periods started (menarche) 1.9 4.6 9.1 -0.1 3.0
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 2.7 0.5 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 0.7 0.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.0 1.0 -0.9
Qualifications: CSEs or equivalent 0.3 0.4 0.8 0.2 -0.9
Serious illness, injury or assault to yourself 1.1 1.3 2.3 -0.5 -1.5
High blood pressure 1.3 3.7 6.5 0.9 -2.5
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.8 -1.7 -0.5
Multivitamins +/- minerals 1.1 1.5 2.8 -0.3 -1.7
Stomach or abdominal pain in last month 2.3 2.9 5.2 -2.3 -0.7
Supplements: Glucosamine 0.0 0.1 0.1 0.3 0.2
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 1.5 1.2 0.7
Medication: Atenolol 0.5 0.6 0.7 -0.8 0.8
Medication: Levothyroxine sodium 0.6 0.9 1.6 1.3 0.5
Sitting height 1.1 7.6 7.9 -2.7 -2.8
Chronic bronchitis/emphysema (father) 0.7 0.8 1.6 -1.3 -0.2
High blood pressure (mother) 0.1 0.1 0.2 0.4 0.1
Body mass index (BMI) 0.7 3.1 4.5 1.3 2.1
Impedance of leg (left) 0.3 1.4 1.6 -1.3 -1.1
Leg predicted mass (left) 0.0 0.2 0.3 0.5 -0.4
Trunk fat mass 0.1 0.5 0.5 0.7 0.7
Waist circumference 0.6 2.3 4.3 0.6 2.1
Number of incorrect matches in round 0.3 0.4 0.5 -0.6 0.7
Past tobacco smoking 0.6 1.1 2.2 -0.1 -1.5
Alcohol usually taken with meals 0.4 0.7 1.3 1.1 0.3
Nervous feelings 0.5 0.8 0.9 0.9 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.0 0.8 -1.0
Hearing difficulty/problems with background noise 0.2 0.4 0.8 0.1 -0.9
Hair/balding pattern: Pattern 2 1.6 2.0 3.3 1.8 0.9
Had menopause 1.1 1.4 1.5 -1.1 -1.2
Had other major operations 0.3 0.3 0.6 -0.8 -0.2
Forced vital capacity (FVC) 2.6 10.2 17.5 -1.7 -4.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.4 0.1 0.6
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 3.4 -1.1 -1.8
Qualifications: None of the above 0.5 1.1 1.7 -0.7 -1.3
Financial difficulties in last 2 years 0.8 1.1 1.5 -0.8 1.2
Mouth/teeth dental problems 0.3 0.5 0.7 0.9 -0.5
Heart attack 1.6 2.1 2.2 -1.4 -1.5
Allergy 0.9 2.0 3.7 1.9 0.6
Pain all over the body in last month 0.8 0.8 1.0 1.0 -0.8
Diabetes (self-reported) 0.7 1.1 1.4 0.9 -1.2
Hayfever/allergic rhinitis (self-reported) 1.2 1.5 2.3 -1.5 0.9
Medication: Ramipril 0.7 0.9 1.1 0.9 -1.0
Medication: Simvastatin 0.8 1.1 2.1 1.4 -0.4
Fluid intelligence score 0.1 0.3 0.5 -0.1 0.7
Illnesses of siblings 0.9 1.2 1.6 1.3 0.9
Neuroticism score 0.8 1.7 3.3 0.3 -1.8
Weight 0.0 0.2 0.3 0.5 0.3
Impedance of arm (right) 0.1 0.2 0.5 -0.7 0.0
Arm fat percentage (right) 1.0 4.0 6.2 1.3 2.5
Trunk fat-free mass 0.2 0.9 1.8 0.2 -1.3
Hip circumference 0.1 0.5 1.0 1.0 0.1
Time employed in main current job 1.1 1.3 2.4 -0.5 -1.5
Alcohol intake versus 10 years previously 2.3 3.5 6.6 2.6 -0.6
Father’s age at death 0.5 0.7 0.8 -0.7 0.9
Worrier / anxious feelings 1.3 2.5 4.9 -0.1 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.5 -0.4 -0.7
Falls in the last year 0.2 0.2 0.4 -0.6 0.2
Hair/balding pattern: Pattern 3 3.4 5.0 8.8 -1.1 -3.0
Number of live births 0.4 0.5 1.0 -1.0 -0.1
Forced expiratory volume in 1-second (FEV1) 2.1 7.0 13.0 -1.0 -3.6
Pulse rate 0.5 0.8 1.4 0.4 1.2
Happiness 0.8 1.0 2.0 -0.1 -1.4
Noisy workplace 0.7 0.9 1.6 1.3 -0.3
Qualifications: A levels/AS levels or equivalent 0.4 1.0 2.0 0.0 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.9 0.0 0.9
Mouth/teeth dental problems: Dentures 0.3 0.5 0.7 0.6 -0.8
Asthma 0.4 0.8 1.0 -0.7 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.9 -0.9 0.1
Medication: Cholesterol lowering 0.6 1.0 2.0 1.4 -0.0
Depression (self-reported) 0.3 0.3 0.4 -0.4 0.7
Medication: Lansoprazole 1.8 2.0 3.1 1.0 -1.7
Prospective memory result 2.3 2.9 5.5 0.5 -2.3
Lung cancer (father) 1.1 1.2 1.5 1.0 -1.2
Illnesses of mother 0.3 0.4 0.7 -0.9 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.6 8.4 15.1 -1.3 -3.9
Pulse wave Arterial Stiffness index 1.8 2.1 4.1 0.2 2.0
Impedance of arm (left) 0.1 0.6 1.0 -0.6 -1.0
Arm fat mass (right) 0.5 1.9 2.8 1.0 1.7
Trunk predicted mass 0.2 0.9 1.8 0.2 -1.4
Standing height 0.8 7.9 13.6 -1.5 -3.7
Length of working week for main job 0.0 0.0 0.0 0.1 -0.2
Exposure to tobacco smoke at home 1.4 1.6 3.0 0.5 -1.7
Breastfed as a baby 0.0 0.1 0.1 -0.0 0.3
Tense / ‘highly strung’ 0.9 1.5 2.5 0.8 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 0.9 0.8 -0.9
Hair/balding pattern: Pattern 4 0.1 0.2 0.5 -0.7 0.1
Birth weight of first child 0.3 0.5 0.8 0.9 -0.4
Peak expiratory flow (PEF) 2.3 5.3 10.6 0.2 -3.3
Pulse wave reflection index 0.5 0.6 1.1 1.0 0.3
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.3 -0.6 -1.2
Loud music exposure frequency 0.5 0.6 0.7 0.9 0.6
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 1.7 -1.2 1.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 -1.0 0.1
Blood clot in the leg (DVT) 0.2 0.3 0.4 -0.6 0.3
Medication: Paracetamol 0.7 1.2 1.7 -1.3 -0.8
Headache pain in last month 0.8 1.4 2.9 -0.1 -1.7
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 1.8 -1.3 1.1
Glaucoma (self-reported) 1.5 1.7 1.8 -1.3 1.3
Gout (self-reported) 2.5 3.5 6.9 2.6 0.2
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.8 0.5 1.3
Medication: Amlodipine 1.8 2.5 4.0 2.0 -1.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 -0.1 0.9
Birth weight 0.0 0.0 0.0 -0.1 0.2
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.6 0.8 -0.1
High blood pressure (siblings) 0.6 0.9 1.8 -0.2 -1.3
Forced vital capacity (FVC), Best measure 3.2 11.6 20.6 -1.6 -4.5
Body fat percentage 0.4 1.7 2.4 1.0 1.6
Leg fat percentage (right) 0.6 2.3 4.2 0.6 2.0
Arm fat-free mass (right) 0.3 1.5 2.8 0.4 -1.7
Exposure to tobacco smoke outside home 1.4 1.8 3.0 -0.8 -1.7
Comparative body size at age 10 0.4 1.1 1.4 -0.9 -1.2
Number of full brothers 1.9 2.3 3.4 -1.1 1.8
Worry too long after embarrassment 0.4 0.7 0.8 -0.8 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 3.6 4.6 8.1 -1.1 -2.8
Wheeze or whistling in the chest in last year 0.2 0.3 0.4 0.6 -0.3
Number of children fathered 0.5 0.5 0.5 -0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 -0.0 0.2
Age at first live birth 0.2 0.4 0.7 0.1 0.8
Pulse wave peak to peak time 2.2 2.6 5.1 -0.3 -2.3
Health satisfaction 0.7 0.9 1.7 1.3 -0.2
Shortness of breath walking on level ground 0.0 0.0 0.0 -0.2 0.1
Qualifications: College or University degree 1.7 5.4 9.6 -1.1 3.1
Eye problems/disorders: None of the above 0.5 0.6 0.8 0.9 -0.6
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.4 -0.7 0.6
Emphysema/chronic bronchitis 1.3 1.4 2.8 1.7 -0.2
Medication for pain relief, constipation, heartburn 0.4 0.6 1.1 1.0 0.4
Neck or shoulder pain in last month 1.0 1.5 2.6 -0.6 -1.6
Medication: Blood pressure 0.5 0.8 0.9 0.9 -0.9
Angina (self-reported) 0.9 1.2 2.3 1.5 -0.1
Migraine (self-reported) 0.6 0.8 0.9 1.0 0.8
Medication: Ibuprofen 0.3 0.4 0.6 -0.8 0.5
Medication: Allopurinol 2.1 2.9 5.7 2.4 0.0
Medication: Omeprazole 0.4 0.5 0.9 -0.9 -0.3
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.2 -0.4
Mean time to correctly identify matches 0.5 1.0 2.0 -1.4 -0.2
Heart disease (mother) 0.7 0.8 1.2 -1.1 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.1 4.1 0.0 -2.0
Whole body fat mass 0.2 0.7 0.9 0.7 0.9
Leg fat mass (right) 0.4 1.6 2.9 0.6 1.7
Arm predicted mass (right) 0.2 1.1 2.1 0.3 -1.4
Pulse rate, automated reading 0.2 0.6 1.2 0.1 1.1
Alcohol intake frequency. 4.0 9.4 14.9 3.9 -2.0
Comparative height size at age 10 1.2 6.4 12.8 -0.1 -3.6
Number of full sisters 4.5 5.5 7.7 -2.8 1.8
Suffer from ‘nerves’ 1.6 2.4 4.0 1.0 -2.0
Overall health rating 0.0 0.1 0.1 -0.3 -0.1
Chest pain or discomfort 1.0 1.4 2.8 -0.3 -1.7
Had major operations 0.0 0.0 0.0 -0.1 0.1
Age at last live birth 0.2 0.4 0.4 -0.6 0.6
Family relationship satisfaction 0.1 0.1 0.3 0.5 -0.0
Leg pain on walking 1.1 1.3 1.7 -1.3 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.3 0.7 -1.1
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.8 0.0 -1.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.6 0.8 -0.7
Medication: Aspirin 0.1 0.1 0.2 0.4 0.0
Supplements: Vitamin C 0.2 0.2 0.4 -0.3 -0.6
Knee pain experienced in last month 0.6 1.0 1.4 -0.7 -1.2
Hypertension (Self-reported) 1.1 3.1 4.4 1.4 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 1.7 -0.5 -1.3
Illnesses of father: Heart disease 0.7 1.0 1.6 -1.3 -0.7
Illnesses of siblings: Diabetes 1.1 1.3 2.6 -1.6 0.2
Smoking status: Previous 0.6 0.9 1.8 -0.3 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 1.5 0.9 -1.2
Whole body fat-free mass 0.1 0.7 1.3 0.4 -1.1
Leg fat-free mass (right) 0.1 0.5 0.5 0.7 -0.7
Arm fat percentage (left) 0.7 2.9 4.0 1.3 2.0
Average weekly red wine intake 0.4 0.6 1.2 -0.2 1.1
Handedness (chirality/laterality): Left-handed 1.7 2.1 4.0 0.4 -2.0
Mood swings 0.5 0.9 1.8 0.1 -1.4
Loneliness, isolation 0.9 1.2 1.7 -0.8 -1.3
Long-standing illness, disability or infirmity 0.6 1.0 1.4 1.2 -0.7
Ever had bowel cancer screening 1.4 1.6 2.9 0.5 -1.7
Diabetes diagnosed by doctor 0.4 0.6 0.7 0.7 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.5 0.6 -0.7
Friendships satisfaction 0.5 0.7 1.2 1.1 0.4
Qualifications: nursing, teaching 0.2 0.3 0.6 -0.8 0.3
Commuting to job workplace: Walk 0.8 0.9 1.5 0.5 -1.2
Eye problems/disorders: Cataract 0.5 0.5 0.7 -0.6 0.8
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 -0.0 0.3
Medication for cholesterol 1.9 2.9 4.0 -1.4 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.4 -0.7 0.1
Back pain experienced in last month 0.3 0.4 0.8 -0.9 0.1
Mineral and other dietary supplements 1.4 1.8 3.6 0.2 1.9
Breast cancer (self-reported) 1.0 1.2 2.3 -0.3 -1.5
Asthma (self-reported) 0.3 0.6 0.9 -0.9 -0.5
Osteoporosis (self-reported) 0.8 1.0 1.1 -1.0 -1.0
Osteoarthritis (self-reported) 3.3 4.3 7.8 2.8 -0.9
Medication: Aspirin 0.1 0.2 0.2 0.5 -0.3
Medication: Gliclazide 0.6 0.6 0.9 0.9 -0.6
Illnesses of father: None of the above (group 1) 0.6 0.7 0.7 0.9 0.8
Smoking status: Current 0.2 0.3 0.4 0.7 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.7 5.0 -2.2 -1.6
Whole body water mass 0.1 0.6 1.0 0.4 -1.0
Leg predicted mass (right) 0.1 0.4 0.5 0.6 -0.7
Arm fat mass (left) 0.3 1.4 2.1 0.9 1.4
Number of self-reported non-cancer illnesses 0.8 1.4 2.5 1.6 -0.5
Average weekly champagne plus white wine intake 0.2 0.3 0.5 0.1 0.7
Miserableness 0.4 0.7 1.1 -0.5 -1.0
Guilty feelings 0.8 1.3 2.2 1.5 -0.6
Wears glasses or contact lenses 0.6 0.7 1.0 -0.7 -1.0
Ever taken oral contraceptive pill 1.0 1.1 2.1 -0.3 1.4
Hearing aid user 1.2 1.3 2.4 0.5 -1.5
Mother’s age at death 4.1 5.2 6.5 1.9 2.5
Financial situation satisfaction 0.3 0.4 0.7 -0.4 0.9
Tinnitus: Yes, now most or all of the time 2.6 3.0 5.7 2.4 0.5
Commuting to job workplace: Public transport 0.3 0.4 0.4 0.7 0.5
Eye problems/disorders: Glaucoma 0.0 0.0 0.1 -0.3 0.2
Medication: Blood pressure 2.8 5.4 8.7 1.4 -3.0
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.6 1.3 0.1
Supplements: Fish oil (including cod liver oil) 1.5 1.9 2.3 -1.2 -1.5
High cholesterol (Self-reported) 1.2 2.0 4.0 2.0 0.4
Medication: Bendroflumethiazide 0.0 0.0 0.0 0.2 -0.0
Medication: Paracetamol 0.6 1.0 1.9 -1.4 0.0
Medication: Lisinopril 0.2 0.2 0.4 -0.6 0.2
Medication: Atorvastatin 0.8 1.0 1.6 1.2 0.7
Illnesses of father: High blood pressure 2.1 2.7 2.8 -1.6 1.7
Alcohol drinker status: Never 0.4 0.5 1.0 1.0 -0.1
Ever smoked 0.3 0.6 1.1 0.3 1.1
Basal metabolic rate 0.1 0.5 0.6 0.6 -0.8
Leg fat percentage (left) 0.4 1.6 2.6 0.7 1.6
Arm fat-free mass (left) 0.1 0.3 0.5 0.3 -0.7
Number of operations (self-reported) 0.3 0.4 0.8 0.3 -0.9
Average weekly beer plus cider intake 1.4 2.1 3.3 -1.8 -0.9
Irritability 0.4 0.8 1.5 0.1 -1.2
Risk taking 0.4 0.6 1.1 -1.0 -0.3
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.3 1.1 0.8
Fractured/broken bones in last 5 years 2.4 3.1 5.5 -0.8 -2.4
Age started oral contraceptive pill 0.5 0.6 1.0 -1.0 -0.4
Diastolic blood pressure, automated reading 0.5 1.5 2.8 0.5 1.7
Ever depressed for a whole week 2.6 3.2 3.8 -1.9 -1.6
Unable to work because of sickness or disability 0.4 0.5 1.0 -0.1 1.0
Commuting to job workplace: Cycle 0.1 0.1 0.1 0.3 -0.3
Myopia 0.8 1.1 1.3 -1.1 -1.0
Vascular/heart problems diagnosed by doctor 1.1 3.0 5.2 -0.9 2.3
Cholesterol lowering medication 0.1 0.1 0.2 0.4 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.2 -0.7
Pain experienced in last month 0.8 1.4 2.6 0.3 1.6
Supplements: Calcium 1.2 1.3 2.4 -0.4 -1.6
Basal cell carcinoma (self-reported) 4.0 4.7 7.7 -2.8 -1.3
Heart attack/myocardial infarction (self-reported) 1.5 2.0 2.3 -1.3 -1.5
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.1 -0.3 0.1
Heart disease (siblings) 0.1 0.2 0.2 -0.5 -0.4
Alcohol drinker status: Previous 2.1 2.4 3.5 1.9 -1.2
Pack years of smoking 1.9 2.7 5.4 -0.1 -2.3
Impedance of whole body 0.2 0.8 0.9 -0.8 -1.0
Leg fat mass (left) 0.3 1.1 1.8 0.6 1.4
Arm predicted mass (left) 0.1 0.3 0.4 0.4 -0.6