Hub : Genes

KPTN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.2390	0.0850	0.00500	-0.010	NA	-0.009	NA	-0.009	0.83000	NA	7.3e-01	NA	0.73000
2	GTEx	Brain Frontal Cortex BA9	0.2611	0.1005	0.00970	0.014	NA	-0.011	NA	-0.003	0.13000	NA	9.0e-01	NA	0.41000
3	GTEx	Cells Transformed fibroblasts	0.1460	0.0490	0.00033	0.012	NA	0.030	NA	0.016	0.04200	NA	2.4e-03	NA	0.02100
4	GTEx	Testis	0.1830	0.0680	0.00190	0.025	NA	0.018	NA	0.023	0.02800	NA	5.2e-02	NA	0.03100
5	METSIM	Adipose	0.0594	0.0247	0.00230	0.029	0.01	0.025	0.018	0.020	0.00003	0.0095	9.9e-05	0.00094	0.00045

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.6	2.5	4.9	0.0	-1.0	-2.2	2.2	-1.3
Bipolar Disorder or Schizophrenia	1.0	2.5	5.2	-0.7	0.8	-1.9	2.3	-1.5
Depressed Affect (Nagel 2018)	0.4	0.7	2.5	-1.6	-0.8	-0.0	0.7	-0.1
Depression (Nagel 2018)	1.1	1.6	5.0	-0.6	-2.2	-1.5	0.6	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.6	-0.6	-0.8	1.3	-0.0	0.5
Neuroticism (Nagel 2018)	1.6	3.7	10.0	-3.2	-2.5	-1.1	1.0	0.2
Schizophrenia (2018)	0.3	0.6	1.3	-0.3	0.7	-0.6	1.1	-1.0
Schizophrenia vs Biploar Disorder	0.9	1.1	3.6	0.0	-0.7	1.9	0.0	1.2
Worry (Nagel 2018)	2.2	4.6	11.7	-3.4	-2.8	-1.9	-0.1	0.5
Alzheimer’s Disease (in mother)	0.9	1.0	3.0	1.7	0.9	-0.1	-0.4	1.1
Alzheimer’s Disease (in father)	0.5	0.5	0.9	0.2	-1.0	-0.2	0.9	0.8
Alzheimer’s Disease (including proxy)	1.5	2.2	4.5	2.1	1.1	-1.0	0.4	2.1
Crohns Disease (2017)	0.8	1.8	4.8	-1.2	-0.7	1.4	-2.2	-0.6
Irritable Bowel Disease (IBD)	0.8	2.0	3.8	-1.9	-1.2	1.0	-1.7	-1.1
Ulcerative Colitis (UC)	0.7	1.2	3.1	-1.8	-1.5	0.4	-0.2	-0.6
Major Depression (MDD)	2.3	2.8	6.0	-1.8	-2.5	0.0	-1.5	1.5
Reaction Time	1.0	1.8	3.1	-0.9	-1.7	1.8	-0.4	1.5
Verbal and Numeric Reasoning (VNR)	1.2	2.8	7.6	-0.7	-1.0	2.8	-1.4	1.7
Breast Cancer	0.3	0.7	3.0	0.5	-0.1	1.7	-0.1	-0.3
Ovarian Cancer	1.7	2.2	5.2	0.9	-0.5	1.4	-2.3	-1.6
Prostate Cancer	0.9	1.3	2.8	-0.2	1.0	-1.7	-0.9	-1.3
Age at First Birth	0.8	1.2	2.7	1.6	0.0	-0.9	-1.2	1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	2.0	0.0	0.5	1.4	-0.8	0.5
Coronary Artery Disease (CAD)	1.3	1.6	6.4	0.0	0.9	2.5	0.1	0.8
Crohns Disease (2012)	0.6	0.9	2.1	0.0	-1.5	1.3	0.0	-0.9
Mean Putamen Volume	0.5	0.5	1.5	1.2	-0.6	-0.6	0.3	-0.6
Fasting Glucose	0.5	0.6	1.7	0.4	-0.1	1.0	-0.2	-1.3
HbA1C	0.3	0.4	1.8	-0.1	-1.3	-0.1	0.3	0.2
HDL Cholesterol	4.0	6.7	18.1	-0.7	-1.8	-4.3	3.4	-0.4
LDL Cholesterol	0.2	0.3	1.3	0.4	1.1	-0.0	0.1	0.1
Lupus	1.0	1.5	3.1	-0.5	0.7	-1.1	1.8	-1.6
Neuroticism (2016)	0.9	1.4	3.2	-0.1	-0.8	-1.1	1.8	1.3
Primary Biliary Cirrhosis	0.6	0.9	2.2	-0.5	-0.6	-1.5	-0.0	-1.3
Rheumatoid Arthritis	1.3	1.8	4.4	-2.1	-1.3	-0.2	1.4	0.9
Schizophrenia (2014)	0.3	0.7	2.7	-0.0	0.7	-0.3	1.6	-0.3
Triglycerides	2.2	3.5	7.0	1.8	2.6	2.0	-0.7	1.7
Type 2 Diabetes (T2D) (2012)	1.4	1.6	5.7	0.0	1.2	2.4	0.0	1.0
Ulcerative Colitis	0.3	0.4	1.2	0.0	-0.6	-0.8	-0.0	-1.1
Blood Eosinophil Count	1.4	10.7	35.6	-3.6	-6.0	0.1	-0.6	2.2
Blood Platelet Count	0.7	7.8	16.8	-2.1	-4.1	-3.8	1.7	0.5
Blood Red Count	0.6	6.0	14.4	-3.5	-3.8	-0.3	-1.5	-1.1
Blood White Count	3.1	23.2	55.5	-7.0	-7.5	-1.1	-2.8	-1.6
Heel T-Score	0.2	2.0	7.4	0.3	-0.5	-1.2	2.7	-0.7
BMI	0.2	1.3	3.1	0.1	0.7	1.8	1.6	0.7
Height	0.3	5.6	18.0	-1.9	-4.2	-2.4	0.9	-0.3
Waist Hip Ratio (WHR)	0.2	0.8	2.4	0.6	-1.5	0.6	0.4	0.9
Systolic Blood Pressure	0.0	0.2	0.6	0.5	0.8	0.2	-0.1	0.1
Smoking Status	0.4	1.0	1.9	1.3	1.4	0.8	0.8	-0.4
Allergy or Eczema	0.4	1.0	3.0	-1.1	-1.7	0.6	-0.3	0.8
Cardiovascular Disease	0.3	1.1	3.0	0.6	1.7	1.5	-0.0	0.2
Hypothyroidism (self reported)	1.4	3.1	6.7	0.7	1.0	2.6	-1.7	2.2
Respiratory disease	1.9	4.2	9.8	-2.8	-3.1	0.9	-1.5	0.5
Type 2 Diabetes (T2D) (2018)	3.0	5.7	13.5	1.4	1.5	3.7	-1.7	2.7
Lung FEV1/FVC ratio	1.1	5.4	17.6	2.4	4.2	-1.8	0.7	-0.3
Lung FVC	0.3	1.6	4.0	0.7	1.8	-0.6	0.0	-2.0
Neuroticism	1.2	2.8	8.0	-2.8	-1.8	-0.9	1.3	-0.5
Chronotype (morning person)	0.3	0.8	1.9	0.2	-1.1	0.8	-0.4	-1.4
Hair Pigment	0.0	1.2	3.9	0.3	0.1	-2.0	0.8	-1.1
Tanning	0.2	2.4	4.1	-0.6	-2.0	-1.8	1.8	-0.9
Hand grip strength (left)	0.9	2.4	7.3	-2.7	-1.8	-0.7	-1.0	-0.4
Number of treatments/medications taken	0.2	0.4	1.1	-0.5	0.3	0.0	-0.7	-1.1
Average weekly spirits intake	0.5	0.6	1.7	0.7	0.0	0.6	-1.3	0.8
Sensitivity / hurt feelings	0.3	0.5	2.5	-0.2	-0.0	0.2	1.6	-0.3
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.4	-0.2	-1.5	0.0	0.3	1.1
Hearing difficulty/problems: Yes	0.8	1.2	4.0	-0.8	-2.0	0.1	-0.1	-1.1
Relative age of first facial hair	1.2	2.5	4.8	-1.8	-1.9	-2.2	0.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.4	-0.3	-0.7	0.4	-1.6	1.4
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.5	0.3	0.8	1.1	-1.2	0.4
Ever had hysterectomy (womb removed)	0.7	0.8	1.9	-0.6	-0.3	1.4	-0.2	1.3
Systolic blood pressure, automated reading	0.0	0.1	0.4	-0.2	0.0	0.6	-0.3	-0.1
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	4.1	1.9	-0.4	2.0	-1.0	1.9
Angina	0.5	0.6	1.4	1.2	1.2	0.3	0.2	0.2
Medication for hormone replacement therapy	0.2	0.2	0.8	-0.5	0.1	-0.9	-0.2	0.2
Vitamin and mineral supplements	0.7	1.0	2.8	0.0	-0.7	-0.6	1.1	-1.7
Supplements: Zinc	1.6	1.7	4.0	1.1	1.4	1.1	-0.6	2.0
Medication: Co-codamol	0.8	1.0	2.7	-0.6	0.7	1.6	-0.6	1.0
Medication: Metformin	1.3	1.9	3.0	1.2	0.6	1.5	-1.7	1.6
Diabetes (father)	0.6	0.8	2.2	1.5	-0.1	0.1	1.2	0.5
Diabetes (mother)	0.3	0.4	0.8	-0.9	0.4	-0.7	-0.6	-0.5
Severe depression (siblings)	0.6	0.7	1.1	-0.6	-1.0	-0.1	0.9	-1.0
Pack years adult smoking proportion	0.8	1.3	5.2	-1.0	-2.3	-0.2	-0.5	0.4
Impedance of leg (right)	0.5	2.6	6.6	-1.8	-1.8	-2.6	-0.4	0.1
Leg fat-free mass (left)	0.1	0.7	2.6	0.6	-0.5	1.6	0.4	-0.0
Trunk fat percentage	0.2	0.6	2.2	-0.1	0.0	1.5	0.6	0.7
Hand grip strength (right)	1.0	2.7	6.2	-2.5	-2.2	-1.1	-1.1	0.1
Townsend deprivation index at recruitment	1.3	1.8	8.0	-0.1	-0.4	2.8	-0.1	0.9
Current tobacco smoking	0.2	0.4	0.6	0.7	0.8	0.2	0.7	-0.6
Average weekly fortified wine intake	0.5	0.6	2.0	0.5	-0.4	0.8	-1.4	0.4
Maternal smoking around birth	0.2	0.3	0.6	-0.6	0.8	-0.4	0.6	0.2
Fed-up feelings	0.7	1.2	2.2	-1.5	-0.2	0.3	1.5	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	7.9	-1.1	-2.8	-1.1	1.0	0.3
Relative age voice broke	1.3	2.0	5.7	-1.2	-1.2	-2.4	0.5	1.0
Taking other prescription medications	1.1	1.7	4.6	0.5	0.1	1.9	-2.2	0.3
Age when periods started (menarche)	1.6	3.8	8.1	-1.4	-2.0	-2.9	1.7	-1.6
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.7	0.6	0.2	-1.3	2.1	2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.3	-0.6	-0.3	-0.8	0.7	-1.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	-0.4	-0.4	-0.2	-0.2
Qualifications: CSEs or equivalent	0.5	0.6	1.5	0.1	-0.2	-1.2	0.8	-0.8
Serious illness, injury or assault to yourself	0.2	0.3	0.8	0.0	0.5	-0.4	-0.3	0.9
High blood pressure	0.9	2.4	4.6	2.1	2.1	1.0	1.4	-0.0
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.1	-0.3	0.2	-0.3	0.0
Multivitamins +/- minerals	1.3	1.7	4.5	1.1	1.5	0.4	-0.4	2.1
Stomach or abdominal pain in last month	0.7	0.8	2.2	1.4	1.5	0.1	0.1	-0.1
Supplements: Glucosamine	0.8	1.0	2.8	1.0	-0.4	-1.7	-0.1	-1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	0.6	1.4	-0.1	-0.2	-1.1
Medication: Atenolol	1.9	2.3	5.9	2.4	2.3	0.5	0.1	0.2
Medication: Levothyroxine sodium	1.5	2.6	8.2	0.0	0.8	2.9	-1.5	1.3
Sitting height	0.1	0.7	1.1	1.0	1.0	-0.1	1.1	0.0
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	1.1	-0.4	1.0	0.2	-1.2
High blood pressure (mother)	0.9	1.2	3.6	1.9	0.8	-1.1	0.5	0.3
Body mass index (BMI)	0.3	1.4	6.8	0.1	0.1	2.6	0.1	0.4
Impedance of leg (left)	0.5	2.3	5.2	-1.9	-1.6	-2.3	-0.3	0.1
Leg predicted mass (left)	0.1	0.7	2.4	0.7	-0.5	1.6	0.4	0.1
Trunk fat mass	0.2	0.7	2.7	-0.1	-0.5	1.6	0.6	0.6
Waist circumference	0.2	0.8	3.3	0.0	-0.7	1.8	0.7	-0.0
Number of incorrect matches in round	1.3	2.2	7.1	-0.9	-1.5	0.3	-2.7	0.7
Past tobacco smoking	0.9	1.6	3.2	-1.4	-1.4	-0.9	-1.8	0.5
Alcohol usually taken with meals	1.1	1.8	3.8	-1.9	-1.8	-1.3	-0.4	-0.1
Nervous feelings	1.1	2.0	4.9	-2.2	-1.5	-1.5	0.8	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	-0.5	-1.4	-0.4	-0.3	-0.1
Hearing difficulty/problems with background noise	1.8	2.9	8.3	-1.1	-2.9	0.3	0.0	-2.2
Hair/balding pattern: Pattern 2	0.5	0.6	2.2	-0.8	-0.1	-1.5	-0.4	-0.4
Had menopause	0.6	0.8	2.4	-1.5	-0.4	0.9	-0.8	0.3
Had other major operations	0.2	0.3	0.9	-0.6	0.1	-0.2	0.9	0.2
Forced vital capacity (FVC)	0.5	1.7	6.9	-0.2	-0.2	-2.6	0.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.4	-0.9	-0.4	-1.3	1.5	-1.6
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.3	-0.2	-0.7	-1.5	1.8	-1.5
Qualifications: None of the above	0.4	1.0	3.4	0.2	1.8	1.1	0.3	-0.3
Financial difficulties in last 2 years	1.1	1.4	6.1	-0.4	-0.4	-0.5	0.8	-2.5
Mouth/teeth dental problems	0.3	0.5	0.9	-0.9	-0.6	-0.6	-0.4	0.9
Heart attack	0.5	0.6	1.6	-0.3	1.3	0.2	0.9	0.7
Allergy	0.5	1.1	2.7	1.0	1.7	-0.7	1.2	-0.2
Pain all over the body in last month	1.5	1.6	2.9	-1.7	-0.1	1.3	-1.7	0.6
Diabetes (self-reported)	2.7	4.2	6.4	2.0	2.1	2.5	-2.2	1.3
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.5	-1.3	-0.9	0.1	0.7	-2.1
Medication: Ramipril	0.2	0.2	0.6	-0.2	0.4	-0.2	0.5	-0.8
Medication: Simvastatin	0.3	0.5	1.5	-0.1	0.2	1.2	-0.2	-1.0
Fluid intelligence score	0.3	0.5	0.9	-0.2	-0.8	0.9	-0.4	0.9
Illnesses of siblings	0.5	0.7	1.9	-0.5	-1.1	-1.4	-0.3	-0.3
Neuroticism score	2.0	4.2	9.5	-3.1	-2.3	-0.8	1.9	-1.4
Weight	0.2	0.9	2.6	-0.3	-1.2	1.6	0.5	0.0
Impedance of arm (right)	0.2	1.1	4.0	-0.4	1.0	-2.0	0.3	-0.3
Arm fat percentage (right)	0.2	0.9	4.0	0.2	0.5	2.0	-0.1	0.6
Trunk fat-free mass	0.2	0.9	3.6	-0.1	-1.9	1.0	0.0	-0.4
Hip circumference	0.1	0.6	1.7	-0.5	-0.5	1.3	0.9	-0.3
Time employed in main current job	1.7	1.9	5.3	-0.3	-0.4	1.3	-2.3	1.6
Alcohol intake versus 10 years previously	2.1	3.1	10.3	1.1	3.2	-0.1	1.4	-1.3
Father’s age at death	1.1	1.5	5.2	-0.6	-2.3	-0.2	0.9	-1.0
Worrier / anxious feelings	2.6	4.9	14.1	-3.8	-2.8	-1.1	-0.2	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	5.1	0.5	0.8	2.3	-1.5	2.1
Falls in the last year	0.4	0.6	2.2	-0.8	-0.1	0.2	-1.5	-0.2
Hair/balding pattern: Pattern 3	1.5	2.3	5.2	2.3	2.1	-0.3	0.6	1.2
Number of live births	0.4	0.6	0.8	-0.7	0.7	-0.9	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.7	0.3	1.0	-2.4	0.8	-0.9
Pulse rate	0.7	1.2	2.8	-0.6	0.8	1.5	-1.7	-0.1
Happiness	0.3	0.4	0.9	-0.5	0.3	0.8	0.2	-0.9
Noisy workplace	1.8	2.3	4.9	-1.4	0.3	-1.1	2.2	-1.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	1.0	0.4	-0.4	-0.7	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	0.8	1.3	0.4	-0.5	-0.6
Mouth/teeth dental problems: Dentures	0.8	1.4	2.6	1.6	1.2	0.9	1.1	-1.0
Asthma	0.5	1.0	3.6	-1.0	-1.9	0.6	-0.4	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.5	0.4	1.1	-1.3	1.6	0.2
Medication: Cholesterol lowering	0.3	0.5	1.1	0.3	1.1	0.8	-0.3	0.6
Depression (self-reported)	0.8	0.9	1.8	-1.3	-1.3	-0.2	0.9	0.5
Medication: Lansoprazole	0.4	0.5	1.8	1.4	-0.3	0.2	-0.5	-0.3
Prospective memory result	1.5	1.9	5.8	1.1	2.4	1.5	-0.3	-0.0
Lung cancer (father)	0.4	0.4	1.1	1.0	0.3	0.7	0.2	-0.6
Illnesses of mother	0.4	0.5	1.8	-0.7	-0.0	-0.6	1.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	6.8	-0.3	0.5	-2.6	0.4	-0.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-0.4	-0.3	1.2	-1.2	-0.1
Impedance of arm (left)	0.3	1.4	6.6	-0.3	0.4	-2.6	0.5	0.1
Arm fat mass (right)	0.2	1.0	4.6	0.0	-0.2	2.1	0.4	0.4
Trunk predicted mass	0.2	0.9	3.7	0.0	-1.9	0.9	0.0	-0.3
Standing height	0.3	3.0	9.1	-1.0	-3.0	-1.9	1.0	-0.6
Length of working week for main job	1.0	1.1	2.0	-0.9	-1.4	-0.6	-0.7	-1.3
Exposure to tobacco smoke at home	0.4	0.5	1.1	1.0	-0.1	0.3	1.0	-0.3
Breastfed as a baby	1.2	1.5	4.0	-0.2	-0.0	-1.2	1.4	-2.0
Tense / ‘highly strung’	2.0	3.3	7.5	-2.7	-2.7	-1.3	-0.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.1	0.4	-0.2	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.6	1.3	2.9	0.8	-1.0	1.3	1.7	-0.8
Birth weight of first child	0.8	1.5	7.2	-0.1	-0.3	-0.5	0.3	-2.7
Peak expiratory flow (PEF)	0.5	1.1	4.5	0.2	0.8	-2.1	0.4	0.2
Pulse wave reflection index	0.6	0.8	1.4	0.5	-0.8	1.1	-1.2	0.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.2	-1.5	0.1	-1.4	0.5	-1.5
Loud music exposure frequency	0.9	0.9	3.9	-0.7	0.0	-2.0	0.5	0.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.2	-0.3	-2.1	-0.8	0.3	0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.1	-0.1	-0.8	-1.0	0.9	-1.5
Blood clot in the leg (DVT)	0.8	1.1	2.4	0.4	-1.5	0.1	-0.6	1.5
Medication: Paracetamol	1.5	2.4	7.7	0.2	1.6	-2.8	1.3	-0.2
Headache pain in last month	0.8	1.4	5.7	-0.0	1.0	-2.4	0.2	0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.1	-0.9	-1.4	-0.7	-0.0	-0.3
Glaucoma (self-reported)	1.3	1.6	3.4	1.8	1.8	0.8	0.4	-0.7
Gout (self-reported)	0.7	1.0	3.1	-1.8	-0.8	0.9	-0.4	-0.7
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	5.1	0.3	-0.4	2.2	-1.6	1.9
Medication: Amlodipine	0.3	0.4	1.2	-1.1	0.5	0.6	-0.5	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	-0.8	-1.1	0.7	-0.7	0.6
Birth weight	0.6	1.4	2.7	-1.4	-1.6	0.3	0.9	-1.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.4	-0.3	0.1	1.8	-1.5	0.1
High blood pressure (siblings)	0.6	0.8	2.4	0.2	1.6	0.1	0.9	0.9
Forced vital capacity (FVC), Best measure	0.6	2.1	8.3	-0.7	-0.4	-2.9	0.5	-1.0
Body fat percentage	0.2	0.8	3.3	-0.4	-0.3	1.8	0.2	0.7
Leg fat percentage (right)	0.5	1.7	5.7	-0.9	-0.8	2.4	-1.0	0.8
Arm fat-free mass (right)	0.2	1.2	4.3	-0.5	-2.1	1.2	0.0	-0.1
Exposure to tobacco smoke outside home	0.2	0.3	0.7	-0.8	-0.8	0.2	-0.5	0.2
Comparative body size at age 10	0.3	0.9	1.6	0.8	-0.5	1.3	0.9	1.1
Number of full brothers	0.0	0.1	0.1	-0.3	-0.0	-0.2	0.3	-0.1
Worry too long after embarrassment	0.9	1.6	2.8	-1.5	-1.7	-0.6	1.2	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.6	-0.8	0.2	-0.5	1.0	1.3
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	-0.1	-1.4	0.1	-0.0	1.2
Number of children fathered	1.3	1.4	3.9	1.3	-0.7	-1.1	2.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	5.7	-0.4	-1.7	-2.4	-0.1	-0.9
Age at first live birth	1.1	2.0	3.5	1.8	1.1	-1.5	1.9	0.2
Pulse wave peak to peak time	0.5	0.6	1.4	0.1	0.2	-1.2	1.1	0.0
Health satisfaction	1.0	1.3	4.6	-0.2	0.5	1.1	0.3	2.1
Shortness of breath walking on level ground	1.0	1.2	2.0	-1.4	-0.9	-0.8	1.3	0.7
Qualifications: College or University degree	0.8	2.5	3.8	1.9	2.0	-0.4	-1.7	1.3
Eye problems/disorders: None of the above	2.0	2.3	5.1	-2.2	-1.0	-2.0	0.1	-1.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.0	0.0	0.6	-0.9	1.4	0.0
Emphysema/chronic bronchitis	0.8	0.9	2.6	-1.2	0.3	-0.1	-1.6	-0.6
Medication for pain relief, constipation, heartburn	1.0	1.7	3.8	-1.1	-1.9	0.8	-1.7	-0.3
Neck or shoulder pain in last month	0.7	1.0	4.3	0.2	2.1	0.6	-0.0	-0.1
Medication: Blood pressure	0.5	0.8	2.3	0.8	1.5	-0.1	1.1	0.2
Angina (self-reported)	0.4	0.6	1.7	1.0	1.3	0.1	0.1	0.0
Migraine (self-reported)	0.4	0.5	1.8	-0.1	0.1	-1.4	-0.4	0.7
Medication: Ibuprofen	0.9	1.1	2.1	0.4	1.3	-1.2	1.4	-0.3
Medication: Allopurinol	0.3	0.4	1.1	-0.4	0.8	1.0	0.1	-0.4
Medication: Omeprazole	0.5	0.6	1.8	0.3	0.4	1.3	0.3	1.0
Medication: Seretide 50 evohaler	0.6	0.7	1.4	-0.9	-1.2	0.6	-1.0	-0.3
Mean time to correctly identify matches	2.2	4.1	8.1	-1.9	-2.6	2.8	-1.1	0.8
Heart disease (mother)	0.2	0.2	0.6	-0.4	-0.1	0.1	-0.5	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.4	-2.1	-1.0	0.3	-1.1	0.4
Whole body fat mass	0.2	0.9	3.6	-0.2	-0.7	1.9	0.2	0.4
Leg fat mass (right)	0.4	1.5	6.2	-0.5	-0.8	2.5	-0.6	0.4
Arm predicted mass (right)	0.2	1.1	4.0	-0.4	-2.0	1.1	0.4	-0.4
Pulse rate, automated reading	0.5	1.6	2.9	0.2	1.4	1.5	-0.9	1.7
Alcohol intake frequency.	1.0	2.4	8.5	1.0	2.9	0.6	-0.4	1.3
Comparative height size at age 10	0.4	1.9	6.0	-1.4	-2.4	0.5	0.4	-1.1
Number of full sisters	1.5	1.8	4.5	1.5	2.1	-0.5	1.4	0.3
Suffer from ‘nerves’	0.4	0.6	1.2	-0.9	-1.1	-0.2	0.0	0.8
Overall health rating	1.4	3.1	4.9	1.9	1.8	2.2	-1.6	1.2
Chest pain or discomfort	0.3	0.4	1.6	0.1	-0.6	0.3	0.4	1.3
Had major operations	0.6	0.8	3.2	0.2	-0.6	-0.3	-0.4	1.8
Age at last live birth	1.0	1.4	2.9	1.2	1.7	-1.4	0.8	-0.2
Family relationship satisfaction	0.4	0.5	1.0	-0.5	0.4	1.0	-0.2	-1.0
Leg pain on walking	0.8	1.0	4.2	-2.1	0.8	-0.2	0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.7	-0.2	0.0	-2.2	1.8	-0.1
Commuting to job workplace: Car/motor vehicle	2.1	2.3	4.0	-2.0	-1.3	-1.0	-1.5	-1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.4	0.2	0.3	0.1	-0.9	1.5
Medication: Aspirin	0.8	1.0	2.8	0.9	1.2	1.7	-0.0	0.1
Supplements: Vitamin C	0.6	0.8	1.7	-1.3	0.8	0.8	-0.6	-0.7
Knee pain experienced in last month	0.7	1.1	2.9	1.2	1.7	-1.0	-0.3	0.2
Hypertension (Self-reported)	0.8	2.3	5.1	2.0	2.3	1.0	1.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	0.6	-0.8	-0.8	1.2	-0.9
Illnesses of father: Heart disease	1.2	1.7	3.0	1.4	1.0	0.7	-1.7	1.4
Illnesses of siblings: Diabetes	0.7	0.9	2.1	0.7	1.4	-0.3	1.2	-0.4
Smoking status: Previous	0.6	0.9	1.5	1.2	0.9	0.9	1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.5	-0.1	0.6	-1.9	1.0	-1.4
Whole body fat-free mass	0.1	0.8	1.9	0.2	-1.4	1.4	0.2	-0.3
Leg fat-free mass (right)	0.1	0.7	2.5	0.6	-0.4	1.6	0.5	-0.2
Arm fat percentage (left)	0.2	0.8	3.5	0.2	0.4	1.9	0.1	0.7
Average weekly red wine intake	0.9	1.3	2.9	-1.7	-0.6	-1.2	-1.4	-0.3
Handedness (chirality/laterality): Left-handed	1.0	1.1	2.3	-1.5	-0.9	0.8	-1.4	0.3
Mood swings	0.7	1.3	5.2	-0.4	-0.1	-0.6	2.3	-0.8
Loneliness, isolation	0.1	0.1	0.2	0.1	0.4	0.4	0.4	0.0
Long-standing illness, disability or infirmity	0.7	1.1	1.8	1.0	-1.3	0.8	-0.7	1.3
Ever had bowel cancer screening	0.7	0.8	2.1	-1.2	-1.4	-0.1	-0.5	0.4
Diabetes diagnosed by doctor	1.8	2.9	5.3	1.4	1.0	1.8	-2.3	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.8	1.7	0.1	1.0	-0.8	-0.2
Friendships satisfaction	0.7	0.9	1.5	-0.9	0.6	1.2	-1.2	-0.5
Qualifications: nursing, teaching	0.5	0.7	2.9	0.0	-0.7	0.3	-1.7	0.6
Commuting to job workplace: Walk	1.6	1.7	6.9	2.6	0.6	1.1	0.6	-0.0
Eye problems/disorders: Cataract	0.9	1.0	2.3	1.5	1.0	0.4	0.2	1.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.8	-0.4	-0.2	1.1	-1.6	2.2
Medication for cholesterol	0.1	0.2	0.5	0.7	-0.1	-0.1	0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.0	0.3	-0.4	-0.6	0.6
Back pain experienced in last month	0.6	0.8	1.3	-1.1	-1.1	-1.1	0.1	-0.5
Mineral and other dietary supplements	0.7	1.0	3.1	-0.4	-1.7	-0.7	1.1	-0.1
Breast cancer (self-reported)	0.9	1.1	2.4	-0.1	1.5	0.8	-1.6	0.1
Asthma (self-reported)	0.6	1.1	3.3	-1.1	-1.8	0.9	-0.5	0.0
Osteoporosis (self-reported)	1.9	2.3	3.8	-1.5	-1.9	-1.5	-1.0	1.5
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.4	0.3	0.3	-0.7	-0.5
Medication: Aspirin	0.5	0.7	1.6	0.8	1.3	1.0	0.2	0.4
Medication: Gliclazide	2.5	2.8	4.5	1.9	1.3	0.6	-1.9	2.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.9	-1.4	-0.9	-0.2	0.9	-0.3
Smoking status: Current	0.5	0.7	2.3	0.8	1.5	-0.0	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	-0.8	-0.5	-1.4	-0.6	-1.0
Whole body water mass	0.1	0.8	2.1	0.2	-1.4	1.4	0.2	-0.2
Leg predicted mass (right)	0.1	0.7	2.8	0.5	-0.3	1.7	0.5	-0.3
Arm fat mass (left)	0.3	1.1	4.9	0.1	-0.3	2.2	0.3	0.4
Number of self-reported non-cancer illnesses	0.7	1.3	3.9	-0.3	-0.2	2.0	-1.3	0.8
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.1	-0.6	0.6	0.2	-0.2
Miserableness	1.5	2.5	5.6	-2.4	-1.8	-0.7	1.6	-0.9
Guilty feelings	2.0	3.0	9.0	-3.0	-2.2	0.5	0.6	-0.7
Wears glasses or contact lenses	0.3	0.4	1.1	-0.5	-0.4	0.1	-1.0	0.6
Ever taken oral contraceptive pill	0.4	0.5	1.2	-0.0	-0.2	1.0	-1.1	-0.4
Hearing aid user	0.8	0.9	1.5	0.6	0.5	1.2	1.0	1.1
Mother’s age at death	0.2	0.3	0.6	0.1	-0.8	0.8	-0.5	-0.3
Financial situation satisfaction	0.7	0.9	3.2	-0.6	0.4	1.8	0.6	-0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.1	0.5	-1.3	-1.4	-0.8	0.3
Commuting to job workplace: Public transport	0.7	0.9	2.3	1.1	-0.1	0.4	1.5	0.9
Eye problems/disorders: Glaucoma	2.3	2.8	7.1	2.2	2.7	1.4	0.1	0.3
Medication: Blood pressure	0.2	0.3	0.8	0.5	0.9	0.6	0.6	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.1	0.3	-1.5	0.0	-0.2	-0.4
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.2	0.3	1.4	0.9	-1.3	1.5
High cholesterol (Self-reported)	0.3	0.6	1.7	-1.3	-0.3	0.8	-0.2	-0.7
Medication: Bendroflumethiazide	0.6	0.9	2.1	0.2	0.4	1.0	1.4	-1.2
Medication: Paracetamol	1.5	2.4	5.9	-0.2	1.1	-2.4	1.7	-1.4
Medication: Lisinopril	0.9	1.2	3.8	1.0	1.9	1.1	0.0	-0.1
Medication: Atorvastatin	0.6	0.8	2.2	0.9	1.5	-0.1	0.6	0.6
Illnesses of father: High blood pressure	1.2	1.5	3.9	0.7	1.6	-0.0	-0.5	2.0
Alcohol drinker status: Never	0.7	0.9	2.0	-1.4	0.5	0.5	-0.2	1.3
Ever smoked	1.3	2.3	5.6	1.7	1.4	0.5	2.4	-0.9
Basal metabolic rate	0.1	0.8	2.2	0.2	-1.2	1.5	0.4	-0.1
Leg fat percentage (left)	0.5	1.9	6.6	-1.0	-0.8	2.6	-0.9	0.8
Arm fat-free mass (left)	0.2	1.2	2.9	-0.7	-1.7	1.7	-0.1	0.0
Number of operations (self-reported)	0.5	0.8	3.8	-0.2	-0.4	-0.2	0.0	2.0
Average weekly beer plus cider intake	0.5	0.7	2.8	-0.9	-1.7	0.3	0.2	0.1
Irritability	2.2	3.7	12.0	-2.1	-3.5	-1.0	0.9	-0.5
Risk taking	1.9	2.8	4.3	0.9	1.1	2.0	-2.1	2.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.1	-0.3	0.3	-0.2	-0.6
Fractured/broken bones in last 5 years	0.7	0.9	4.0	0.8	2.0	-0.1	-0.2	-0.3
Age started oral contraceptive pill	0.9	1.1	4.9	0.6	-0.5	2.2	-0.3	-0.2
Diastolic blood pressure, automated reading	0.2	0.5	1.0	-0.6	-1.0	-1.0	0.2	0.5
Ever depressed for a whole week	2.0	2.5	5.6	-0.4	-0.2	-1.2	2.3	-2.4
Unable to work because of sickness or disability	1.2	1.5	5.2	-0.1	-0.1	2.3	-1.1	1.0
Commuting to job workplace: Cycle	1.0	1.2	3.6	1.0	1.9	1.0	0.2	-0.7
Myopia	0.4	0.5	1.5	-0.2	1.2	-0.5	0.8	-0.5
Vascular/heart problems diagnosed by doctor	0.8	2.3	5.6	-1.9	-2.4	-1.2	-0.8	-0.3
Cholesterol lowering medication	0.6	0.8	3.0	-0.3	-0.7	1.7	-0.6	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.1	-0.0	0.8	0.8	0.2
Pain experienced in last month	0.5	0.8	1.8	-0.4	-1.2	1.3	-0.6	0.5
Supplements: Calcium	0.6	0.7	3.0	-0.0	0.5	0.5	-1.7	-0.1
Basal cell carcinoma (self-reported)	1.3	1.6	4.9	-1.1	-0.4	1.2	-2.2	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.7	-0.3	1.3	0.4	0.9	0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.8	0.7	-1.3	-0.2	-0.5	1.3
Heart disease (siblings)	0.4	0.5	1.4	0.6	0.6	1.2	0.4	-0.8
Alcohol drinker status: Previous	1.2	1.3	3.7	1.9	1.4	0.6	-0.7	0.2
Pack years of smoking	0.9	1.3	5.4	-0.8	-2.3	0.2	-0.8	0.2
Impedance of whole body	0.3	1.7	7.5	-1.0	-0.1	-2.7	0.4	0.2
Leg fat mass (left)	0.4	1.6	6.5	-0.5	-0.8	2.5	-0.6	0.4
Arm predicted mass (left)	0.2	1.0	2.9	-0.3	-1.7	1.4	0.6	-0.1