Hub : Genes

KPTN

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Caudate basal ganglia 0.2390 0.0850 0.00500 -0.010 NA -0.009 NA -0.009 0.83000 NA 7.3e-01 NA 0.73000
2 GTEx Brain Frontal Cortex BA9 0.2611 0.1005 0.00970 0.014 NA -0.011 NA -0.003 0.13000 NA 9.0e-01 NA 0.41000
3 GTEx Cells Transformed fibroblasts 0.1460 0.0490 0.00033 0.012 NA 0.030 NA 0.016 0.04200 NA 2.4e-03 NA 0.02100
4 GTEx Testis 0.1830 0.0680 0.00190 0.025 NA 0.018 NA 0.023 0.02800 NA 5.2e-02 NA 0.03100
5 METSIM Adipose 0.0594 0.0247 0.00230 0.029 0.01 0.025 0.018 0.020 0.00003 0.0095 9.9e-05 0.00094 0.00045

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.6 2.5 4.9 0.0 -1.0 -2.2 2.2 -1.3
Bipolar Disorder or Schizophrenia 1.0 2.5 5.2 -0.7 0.8 -1.9 2.3 -1.5
Depressed Affect (Nagel 2018) 0.4 0.7 2.5 -1.6 -0.8 -0.0 0.7 -0.1
Depression (Nagel 2018) 1.1 1.6 5.0 -0.6 -2.2 -1.5 0.6 0.4
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.6 -0.6 -0.8 1.3 -0.0 0.5
Neuroticism (Nagel 2018) 1.6 3.7 10.0 -3.2 -2.5 -1.1 1.0 0.2
Schizophrenia (2018) 0.3 0.6 1.3 -0.3 0.7 -0.6 1.1 -1.0
Schizophrenia vs Biploar Disorder 0.9 1.1 3.6 0.0 -0.7 1.9 0.0 1.2
Worry (Nagel 2018) 2.2 4.6 11.7 -3.4 -2.8 -1.9 -0.1 0.5
Alzheimer’s Disease (in mother) 0.9 1.0 3.0 1.7 0.9 -0.1 -0.4 1.1
Alzheimer’s Disease (in father) 0.5 0.5 0.9 0.2 -1.0 -0.2 0.9 0.8
Alzheimer’s Disease (including proxy) 1.5 2.2 4.5 2.1 1.1 -1.0 0.4 2.1
Crohns Disease (2017) 0.8 1.8 4.8 -1.2 -0.7 1.4 -2.2 -0.6
Irritable Bowel Disease (IBD) 0.8 2.0 3.8 -1.9 -1.2 1.0 -1.7 -1.1
Ulcerative Colitis (UC) 0.7 1.2 3.1 -1.8 -1.5 0.4 -0.2 -0.6
Major Depression (MDD) 2.3 2.8 6.0 -1.8 -2.5 0.0 -1.5 1.5
Reaction Time 1.0 1.8 3.1 -0.9 -1.7 1.8 -0.4 1.5
Verbal and Numeric Reasoning (VNR) 1.2 2.8 7.6 -0.7 -1.0 2.8 -1.4 1.7
Breast Cancer 0.3 0.7 3.0 0.5 -0.1 1.7 -0.1 -0.3
Ovarian Cancer 1.7 2.2 5.2 0.9 -0.5 1.4 -2.3 -1.6
Prostate Cancer 0.9 1.3 2.8 -0.2 1.0 -1.7 -0.9 -1.3
Age at First Birth 0.8 1.2 2.7 1.6 0.0 -0.9 -1.2 1.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 2.0 0.0 0.5 1.4 -0.8 0.5
Coronary Artery Disease (CAD) 1.3 1.6 6.4 0.0 0.9 2.5 0.1 0.8
Crohns Disease (2012) 0.6 0.9 2.1 0.0 -1.5 1.3 0.0 -0.9
Mean Putamen Volume 0.5 0.5 1.5 1.2 -0.6 -0.6 0.3 -0.6
Fasting Glucose 0.5 0.6 1.7 0.4 -0.1 1.0 -0.2 -1.3
HbA1C 0.3 0.4 1.8 -0.1 -1.3 -0.1 0.3 0.2
HDL Cholesterol 4.0 6.7 18.1 -0.7 -1.8 -4.3 3.4 -0.4
LDL Cholesterol 0.2 0.3 1.3 0.4 1.1 -0.0 0.1 0.1
Lupus 1.0 1.5 3.1 -0.5 0.7 -1.1 1.8 -1.6
Neuroticism (2016) 0.9 1.4 3.2 -0.1 -0.8 -1.1 1.8 1.3
Primary Biliary Cirrhosis 0.6 0.9 2.2 -0.5 -0.6 -1.5 -0.0 -1.3
Rheumatoid Arthritis 1.3 1.8 4.4 -2.1 -1.3 -0.2 1.4 0.9
Schizophrenia (2014) 0.3 0.7 2.7 -0.0 0.7 -0.3 1.6 -0.3
Triglycerides 2.2 3.5 7.0 1.8 2.6 2.0 -0.7 1.7
Type 2 Diabetes (T2D) (2012) 1.4 1.6 5.7 0.0 1.2 2.4 0.0 1.0
Ulcerative Colitis 0.3 0.4 1.2 0.0 -0.6 -0.8 -0.0 -1.1
Blood Eosinophil Count 1.4 10.7 35.6 -3.6 -6.0 0.1 -0.6 2.2
Blood Platelet Count 0.7 7.8 16.8 -2.1 -4.1 -3.8 1.7 0.5
Blood Red Count 0.6 6.0 14.4 -3.5 -3.8 -0.3 -1.5 -1.1
Blood White Count 3.1 23.2 55.5 -7.0 -7.5 -1.1 -2.8 -1.6
Heel T-Score 0.2 2.0 7.4 0.3 -0.5 -1.2 2.7 -0.7
BMI 0.2 1.3 3.1 0.1 0.7 1.8 1.6 0.7
Height 0.3 5.6 18.0 -1.9 -4.2 -2.4 0.9 -0.3
Waist Hip Ratio (WHR) 0.2 0.8 2.4 0.6 -1.5 0.6 0.4 0.9
Systolic Blood Pressure 0.0 0.2 0.6 0.5 0.8 0.2 -0.1 0.1
Smoking Status 0.4 1.0 1.9 1.3 1.4 0.8 0.8 -0.4
Allergy or Eczema 0.4 1.0 3.0 -1.1 -1.7 0.6 -0.3 0.8
Cardiovascular Disease 0.3 1.1 3.0 0.6 1.7 1.5 -0.0 0.2
Hypothyroidism (self reported) 1.4 3.1 6.7 0.7 1.0 2.6 -1.7 2.2
Respiratory disease 1.9 4.2 9.8 -2.8 -3.1 0.9 -1.5 0.5
Type 2 Diabetes (T2D) (2018) 3.0 5.7 13.5 1.4 1.5 3.7 -1.7 2.7
Lung FEV1/FVC ratio 1.1 5.4 17.6 2.4 4.2 -1.8 0.7 -0.3
Lung FVC 0.3 1.6 4.0 0.7 1.8 -0.6 0.0 -2.0
Neuroticism 1.2 2.8 8.0 -2.8 -1.8 -0.9 1.3 -0.5
Chronotype (morning person) 0.3 0.8 1.9 0.2 -1.1 0.8 -0.4 -1.4
Hair Pigment 0.0 1.2 3.9 0.3 0.1 -2.0 0.8 -1.1
Tanning 0.2 2.4 4.1 -0.6 -2.0 -1.8 1.8 -0.9
Hand grip strength (left) 0.9 2.4 7.3 -2.7 -1.8 -0.7 -1.0 -0.4
Number of treatments/medications taken 0.2 0.4 1.1 -0.5 0.3 0.0 -0.7 -1.1
Average weekly spirits intake 0.5 0.6 1.7 0.7 0.0 0.6 -1.3 0.8
Sensitivity / hurt feelings 0.3 0.5 2.5 -0.2 -0.0 0.2 1.6 -0.3
Frequency of depressed mood in last 2 weeks 0.5 0.8 2.4 -0.2 -1.5 0.0 0.3 1.1
Hearing difficulty/problems: Yes 0.8 1.2 4.0 -0.8 -2.0 0.1 -0.1 -1.1
Relative age of first facial hair 1.2 2.5 4.8 -1.8 -1.9 -2.2 0.6 0.8
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 2.4 -0.3 -0.7 0.4 -1.6 1.4
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.5 0.3 0.8 1.1 -1.2 0.4
Ever had hysterectomy (womb removed) 0.7 0.8 1.9 -0.6 -0.3 1.4 -0.2 1.3
Systolic blood pressure, automated reading 0.0 0.1 0.4 -0.2 0.0 0.6 -0.3 -0.1
Eye problems/disorders: Diabetes related eye disease 2.3 2.5 4.1 1.9 -0.4 2.0 -1.0 1.9
Angina 0.5 0.6 1.4 1.2 1.2 0.3 0.2 0.2
Medication for hormone replacement therapy 0.2 0.2 0.8 -0.5 0.1 -0.9 -0.2 0.2
Vitamin and mineral supplements 0.7 1.0 2.8 0.0 -0.7 -0.6 1.1 -1.7
Supplements: Zinc 1.6 1.7 4.0 1.1 1.4 1.1 -0.6 2.0
Medication: Co-codamol 0.8 1.0 2.7 -0.6 0.7 1.6 -0.6 1.0
Medication: Metformin 1.3 1.9 3.0 1.2 0.6 1.5 -1.7 1.6
Diabetes (father) 0.6 0.8 2.2 1.5 -0.1 0.1 1.2 0.5
Diabetes (mother) 0.3 0.4 0.8 -0.9 0.4 -0.7 -0.6 -0.5
Severe depression (siblings) 0.6 0.7 1.1 -0.6 -1.0 -0.1 0.9 -1.0
Pack years adult smoking proportion 0.8 1.3 5.2 -1.0 -2.3 -0.2 -0.5 0.4
Impedance of leg (right) 0.5 2.6 6.6 -1.8 -1.8 -2.6 -0.4 0.1
Leg fat-free mass (left) 0.1 0.7 2.6 0.6 -0.5 1.6 0.4 -0.0
Trunk fat percentage 0.2 0.6 2.2 -0.1 0.0 1.5 0.6 0.7
Hand grip strength (right) 1.0 2.7 6.2 -2.5 -2.2 -1.1 -1.1 0.1
Townsend deprivation index at recruitment 1.3 1.8 8.0 -0.1 -0.4 2.8 -0.1 0.9
Current tobacco smoking 0.2 0.4 0.6 0.7 0.8 0.2 0.7 -0.6
Average weekly fortified wine intake 0.5 0.6 2.0 0.5 -0.4 0.8 -1.4 0.4
Maternal smoking around birth 0.2 0.3 0.6 -0.6 0.8 -0.4 0.6 0.2
Fed-up feelings 0.7 1.2 2.2 -1.5 -0.2 0.3 1.5 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 7.9 -1.1 -2.8 -1.1 1.0 0.3
Relative age voice broke 1.3 2.0 5.7 -1.2 -1.2 -2.4 0.5 1.0
Taking other prescription medications 1.1 1.7 4.6 0.5 0.1 1.9 -2.2 0.3
Age when periods started (menarche) 1.6 3.8 8.1 -1.4 -2.0 -2.9 1.7 -1.6
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 4.7 0.6 0.2 -1.3 2.1 2.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.3 -0.6 -0.3 -0.8 0.7 -1.5
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.3 -0.4 -0.4 -0.2 -0.2
Qualifications: CSEs or equivalent 0.5 0.6 1.5 0.1 -0.2 -1.2 0.8 -0.8
Serious illness, injury or assault to yourself 0.2 0.3 0.8 0.0 0.5 -0.4 -0.3 0.9
High blood pressure 0.9 2.4 4.6 2.1 2.1 1.0 1.4 -0.0
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.1 0.1 -0.3 0.2 -0.3 0.0
Multivitamins +/- minerals 1.3 1.7 4.5 1.1 1.5 0.4 -0.4 2.1
Stomach or abdominal pain in last month 0.7 0.8 2.2 1.4 1.5 0.1 0.1 -0.1
Supplements: Glucosamine 0.8 1.0 2.8 1.0 -0.4 -1.7 -0.1 -1.1
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.0 0.6 1.4 -0.1 -0.2 -1.1
Medication: Atenolol 1.9 2.3 5.9 2.4 2.3 0.5 0.1 0.2
Medication: Levothyroxine sodium 1.5 2.6 8.2 0.0 0.8 2.9 -1.5 1.3
Sitting height 0.1 0.7 1.1 1.0 1.0 -0.1 1.1 0.0
Chronic bronchitis/emphysema (father) 0.7 0.8 1.4 1.1 -0.4 1.0 0.2 -1.2
High blood pressure (mother) 0.9 1.2 3.6 1.9 0.8 -1.1 0.5 0.3
Body mass index (BMI) 0.3 1.4 6.8 0.1 0.1 2.6 0.1 0.4
Impedance of leg (left) 0.5 2.3 5.2 -1.9 -1.6 -2.3 -0.3 0.1
Leg predicted mass (left) 0.1 0.7 2.4 0.7 -0.5 1.6 0.4 0.1
Trunk fat mass 0.2 0.7 2.7 -0.1 -0.5 1.6 0.6 0.6
Waist circumference 0.2 0.8 3.3 0.0 -0.7 1.8 0.7 -0.0
Number of incorrect matches in round 1.3 2.2 7.1 -0.9 -1.5 0.3 -2.7 0.7
Past tobacco smoking 0.9 1.6 3.2 -1.4 -1.4 -0.9 -1.8 0.5
Alcohol usually taken with meals 1.1 1.8 3.8 -1.9 -1.8 -1.3 -0.4 -0.1
Nervous feelings 1.1 2.0 4.9 -2.2 -1.5 -1.5 0.8 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.0 -0.5 -1.4 -0.4 -0.3 -0.1
Hearing difficulty/problems with background noise 1.8 2.9 8.3 -1.1 -2.9 0.3 0.0 -2.2
Hair/balding pattern: Pattern 2 0.5 0.6 2.2 -0.8 -0.1 -1.5 -0.4 -0.4
Had menopause 0.6 0.8 2.4 -1.5 -0.4 0.9 -0.8 0.3
Had other major operations 0.2 0.3 0.9 -0.6 0.1 -0.2 0.9 0.2
Forced vital capacity (FVC) 0.5 1.7 6.9 -0.2 -0.2 -2.6 0.8 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 2.4 -0.9 -0.4 -1.3 1.5 -1.6
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 3.3 -0.2 -0.7 -1.5 1.8 -1.5
Qualifications: None of the above 0.4 1.0 3.4 0.2 1.8 1.1 0.3 -0.3
Financial difficulties in last 2 years 1.1 1.4 6.1 -0.4 -0.4 -0.5 0.8 -2.5
Mouth/teeth dental problems 0.3 0.5 0.9 -0.9 -0.6 -0.6 -0.4 0.9
Heart attack 0.5 0.6 1.6 -0.3 1.3 0.2 0.9 0.7
Allergy 0.5 1.1 2.7 1.0 1.7 -0.7 1.2 -0.2
Pain all over the body in last month 1.5 1.6 2.9 -1.7 -0.1 1.3 -1.7 0.6
Diabetes (self-reported) 2.7 4.2 6.4 2.0 2.1 2.5 -2.2 1.3
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 4.5 -1.3 -0.9 0.1 0.7 -2.1
Medication: Ramipril 0.2 0.2 0.6 -0.2 0.4 -0.2 0.5 -0.8
Medication: Simvastatin 0.3 0.5 1.5 -0.1 0.2 1.2 -0.2 -1.0
Fluid intelligence score 0.3 0.5 0.9 -0.2 -0.8 0.9 -0.4 0.9
Illnesses of siblings 0.5 0.7 1.9 -0.5 -1.1 -1.4 -0.3 -0.3
Neuroticism score 2.0 4.2 9.5 -3.1 -2.3 -0.8 1.9 -1.4
Weight 0.2 0.9 2.6 -0.3 -1.2 1.6 0.5 0.0
Impedance of arm (right) 0.2 1.1 4.0 -0.4 1.0 -2.0 0.3 -0.3
Arm fat percentage (right) 0.2 0.9 4.0 0.2 0.5 2.0 -0.1 0.6
Trunk fat-free mass 0.2 0.9 3.6 -0.1 -1.9 1.0 0.0 -0.4
Hip circumference 0.1 0.6 1.7 -0.5 -0.5 1.3 0.9 -0.3
Time employed in main current job 1.7 1.9 5.3 -0.3 -0.4 1.3 -2.3 1.6
Alcohol intake versus 10 years previously 2.1 3.1 10.3 1.1 3.2 -0.1 1.4 -1.3
Father’s age at death 1.1 1.5 5.2 -0.6 -2.3 -0.2 0.9 -1.0
Worrier / anxious feelings 2.6 4.9 14.1 -3.8 -2.8 -1.1 -0.2 -1.0
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.5 5.1 0.5 0.8 2.3 -1.5 2.1
Falls in the last year 0.4 0.6 2.2 -0.8 -0.1 0.2 -1.5 -0.2
Hair/balding pattern: Pattern 3 1.5 2.3 5.2 2.3 2.1 -0.3 0.6 1.2
Number of live births 0.4 0.6 0.8 -0.7 0.7 -0.9 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 5.7 0.3 1.0 -2.4 0.8 -0.9
Pulse rate 0.7 1.2 2.8 -0.6 0.8 1.5 -1.7 -0.1
Happiness 0.3 0.4 0.9 -0.5 0.3 0.8 0.2 -0.9
Noisy workplace 1.8 2.3 4.9 -1.4 0.3 -1.1 2.2 -1.8
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.0 1.0 0.4 -0.4 -0.7 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.6 0.8 1.3 0.4 -0.5 -0.6
Mouth/teeth dental problems: Dentures 0.8 1.4 2.6 1.6 1.2 0.9 1.1 -1.0
Asthma 0.5 1.0 3.6 -1.0 -1.9 0.6 -0.4 -0.0
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.5 0.4 1.1 -1.3 1.6 0.2
Medication: Cholesterol lowering 0.3 0.5 1.1 0.3 1.1 0.8 -0.3 0.6
Depression (self-reported) 0.8 0.9 1.8 -1.3 -1.3 -0.2 0.9 0.5
Medication: Lansoprazole 0.4 0.5 1.8 1.4 -0.3 0.2 -0.5 -0.3
Prospective memory result 1.5 1.9 5.8 1.1 2.4 1.5 -0.3 -0.0
Lung cancer (father) 0.4 0.4 1.1 1.0 0.3 0.7 0.2 -0.6
Illnesses of mother 0.4 0.5 1.8 -0.7 -0.0 -0.6 1.4 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 6.8 -0.3 0.5 -2.6 0.4 -0.3
Pulse wave Arterial Stiffness index 0.5 0.6 1.5 -0.4 -0.3 1.2 -1.2 -0.1
Impedance of arm (left) 0.3 1.4 6.6 -0.3 0.4 -2.6 0.5 0.1
Arm fat mass (right) 0.2 1.0 4.6 0.0 -0.2 2.1 0.4 0.4
Trunk predicted mass 0.2 0.9 3.7 0.0 -1.9 0.9 0.0 -0.3
Standing height 0.3 3.0 9.1 -1.0 -3.0 -1.9 1.0 -0.6
Length of working week for main job 1.0 1.1 2.0 -0.9 -1.4 -0.6 -0.7 -1.3
Exposure to tobacco smoke at home 0.4 0.5 1.1 1.0 -0.1 0.3 1.0 -0.3
Breastfed as a baby 1.2 1.5 4.0 -0.2 -0.0 -1.2 1.4 -2.0
Tense / ‘highly strung’ 2.0 3.3 7.5 -2.7 -2.7 -1.3 -0.1 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.1 0.4 -0.2 -0.2 -0.4
Hair/balding pattern: Pattern 4 0.6 1.3 2.9 0.8 -1.0 1.3 1.7 -0.8
Birth weight of first child 0.8 1.5 7.2 -0.1 -0.3 -0.5 0.3 -2.7
Peak expiratory flow (PEF) 0.5 1.1 4.5 0.2 0.8 -2.1 0.4 0.2
Pulse wave reflection index 0.6 0.8 1.4 0.5 -0.8 1.1 -1.2 0.6
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.2 -1.5 0.1 -1.4 0.5 -1.5
Loud music exposure frequency 0.9 0.9 3.9 -0.7 0.0 -2.0 0.5 0.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.2 -0.3 -2.1 -0.8 0.3 0.5
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.1 -0.1 -0.8 -1.0 0.9 -1.5
Blood clot in the leg (DVT) 0.8 1.1 2.4 0.4 -1.5 0.1 -0.6 1.5
Medication: Paracetamol 1.5 2.4 7.7 0.2 1.6 -2.8 1.3 -0.2
Headache pain in last month 0.8 1.4 5.7 -0.0 1.0 -2.4 0.2 0.6
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.1 -0.9 -1.4 -0.7 -0.0 -0.3
Glaucoma (self-reported) 1.3 1.6 3.4 1.8 1.8 0.8 0.4 -0.7
Gout (self-reported) 0.7 1.0 3.1 -1.8 -0.8 0.9 -0.4 -0.7
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 5.1 0.3 -0.4 2.2 -1.6 1.9
Medication: Amlodipine 0.3 0.4 1.2 -1.1 0.5 0.6 -0.5 0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.3 -0.8 -1.1 0.7 -0.7 0.6
Birth weight 0.6 1.4 2.7 -1.4 -1.6 0.3 0.9 -1.2
Chronic bronchitis/emphysema (mother) 1.0 1.2 3.4 -0.3 0.1 1.8 -1.5 0.1
High blood pressure (siblings) 0.6 0.8 2.4 0.2 1.6 0.1 0.9 0.9
Forced vital capacity (FVC), Best measure 0.6 2.1 8.3 -0.7 -0.4 -2.9 0.5 -1.0
Body fat percentage 0.2 0.8 3.3 -0.4 -0.3 1.8 0.2 0.7
Leg fat percentage (right) 0.5 1.7 5.7 -0.9 -0.8 2.4 -1.0 0.8
Arm fat-free mass (right) 0.2 1.2 4.3 -0.5 -2.1 1.2 0.0 -0.1
Exposure to tobacco smoke outside home 0.2 0.3 0.7 -0.8 -0.8 0.2 -0.5 0.2
Comparative body size at age 10 0.3 0.9 1.6 0.8 -0.5 1.3 0.9 1.1
Number of full brothers 0.0 0.1 0.1 -0.3 -0.0 -0.2 0.3 -0.1
Worry too long after embarrassment 0.9 1.6 2.8 -1.5 -1.7 -0.6 1.2 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.6 -0.8 0.2 -0.5 1.0 1.3
Wheeze or whistling in the chest in last year 0.4 0.7 2.1 -0.1 -1.4 0.1 -0.0 1.2
Number of children fathered 1.3 1.4 3.9 1.3 -0.7 -1.1 2.0 0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.7 1.9 5.7 -0.4 -1.7 -2.4 -0.1 -0.9
Age at first live birth 1.1 2.0 3.5 1.8 1.1 -1.5 1.9 0.2
Pulse wave peak to peak time 0.5 0.6 1.4 0.1 0.2 -1.2 1.1 0.0
Health satisfaction 1.0 1.3 4.6 -0.2 0.5 1.1 0.3 2.1
Shortness of breath walking on level ground 1.0 1.2 2.0 -1.4 -0.9 -0.8 1.3 0.7
Qualifications: College or University degree 0.8 2.5 3.8 1.9 2.0 -0.4 -1.7 1.3
Eye problems/disorders: None of the above 2.0 2.3 5.1 -2.2 -1.0 -2.0 0.1 -1.2
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.0 0.0 0.6 -0.9 1.4 0.0
Emphysema/chronic bronchitis 0.8 0.9 2.6 -1.2 0.3 -0.1 -1.6 -0.6
Medication for pain relief, constipation, heartburn 1.0 1.7 3.8 -1.1 -1.9 0.8 -1.7 -0.3
Neck or shoulder pain in last month 0.7 1.0 4.3 0.2 2.1 0.6 -0.0 -0.1
Medication: Blood pressure 0.5 0.8 2.3 0.8 1.5 -0.1 1.1 0.2
Angina (self-reported) 0.4 0.6 1.7 1.0 1.3 0.1 0.1 0.0
Migraine (self-reported) 0.4 0.5 1.8 -0.1 0.1 -1.4 -0.4 0.7
Medication: Ibuprofen 0.9 1.1 2.1 0.4 1.3 -1.2 1.4 -0.3
Medication: Allopurinol 0.3 0.4 1.1 -0.4 0.8 1.0 0.1 -0.4
Medication: Omeprazole 0.5 0.6 1.8 0.3 0.4 1.3 0.3 1.0
Medication: Seretide 50 evohaler 0.6 0.7 1.4 -0.9 -1.2 0.6 -1.0 -0.3
Mean time to correctly identify matches 2.2 4.1 8.1 -1.9 -2.6 2.8 -1.1 0.8
Heart disease (mother) 0.2 0.2 0.6 -0.4 -0.1 0.1 -0.5 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 4.4 -2.1 -1.0 0.3 -1.1 0.4
Whole body fat mass 0.2 0.9 3.6 -0.2 -0.7 1.9 0.2 0.4
Leg fat mass (right) 0.4 1.5 6.2 -0.5 -0.8 2.5 -0.6 0.4
Arm predicted mass (right) 0.2 1.1 4.0 -0.4 -2.0 1.1 0.4 -0.4
Pulse rate, automated reading 0.5 1.6 2.9 0.2 1.4 1.5 -0.9 1.7
Alcohol intake frequency. 1.0 2.4 8.5 1.0 2.9 0.6 -0.4 1.3
Comparative height size at age 10 0.4 1.9 6.0 -1.4 -2.4 0.5 0.4 -1.1
Number of full sisters 1.5 1.8 4.5 1.5 2.1 -0.5 1.4 0.3
Suffer from ‘nerves’ 0.4 0.6 1.2 -0.9 -1.1 -0.2 0.0 0.8
Overall health rating 1.4 3.1 4.9 1.9 1.8 2.2 -1.6 1.2
Chest pain or discomfort 0.3 0.4 1.6 0.1 -0.6 0.3 0.4 1.3
Had major operations 0.6 0.8 3.2 0.2 -0.6 -0.3 -0.4 1.8
Age at last live birth 1.0 1.4 2.9 1.2 1.7 -1.4 0.8 -0.2
Family relationship satisfaction 0.4 0.5 1.0 -0.5 0.4 1.0 -0.2 -1.0
Leg pain on walking 0.8 1.0 4.2 -2.1 0.8 -0.2 0.1 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 4.7 -0.2 0.0 -2.2 1.8 -0.1
Commuting to job workplace: Car/motor vehicle 2.1 2.3 4.0 -2.0 -1.3 -1.0 -1.5 -1.6
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 2.4 0.2 0.3 0.1 -0.9 1.5
Medication: Aspirin 0.8 1.0 2.8 0.9 1.2 1.7 -0.0 0.1
Supplements: Vitamin C 0.6 0.8 1.7 -1.3 0.8 0.8 -0.6 -0.7
Knee pain experienced in last month 0.7 1.1 2.9 1.2 1.7 -1.0 -0.3 0.2
Hypertension (Self-reported) 0.8 2.3 5.1 2.0 2.3 1.0 1.3 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.4 0.6 -0.8 -0.8 1.2 -0.9
Illnesses of father: Heart disease 1.2 1.7 3.0 1.4 1.0 0.7 -1.7 1.4
Illnesses of siblings: Diabetes 0.7 0.9 2.1 0.7 1.4 -0.3 1.2 -0.4
Smoking status: Previous 0.6 0.9 1.5 1.2 0.9 0.9 1.2 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 3.5 -0.1 0.6 -1.9 1.0 -1.4
Whole body fat-free mass 0.1 0.8 1.9 0.2 -1.4 1.4 0.2 -0.3
Leg fat-free mass (right) 0.1 0.7 2.5 0.6 -0.4 1.6 0.5 -0.2
Arm fat percentage (left) 0.2 0.8 3.5 0.2 0.4 1.9 0.1 0.7
Average weekly red wine intake 0.9 1.3 2.9 -1.7 -0.6 -1.2 -1.4 -0.3
Handedness (chirality/laterality): Left-handed 1.0 1.1 2.3 -1.5 -0.9 0.8 -1.4 0.3
Mood swings 0.7 1.3 5.2 -0.4 -0.1 -0.6 2.3 -0.8
Loneliness, isolation 0.1 0.1 0.2 0.1 0.4 0.4 0.4 0.0
Long-standing illness, disability or infirmity 0.7 1.1 1.8 1.0 -1.3 0.8 -0.7 1.3
Ever had bowel cancer screening 0.7 0.8 2.1 -1.2 -1.4 -0.1 -0.5 0.4
Diabetes diagnosed by doctor 1.8 2.9 5.3 1.4 1.0 1.8 -2.3 1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 2.8 1.7 0.1 1.0 -0.8 -0.2
Friendships satisfaction 0.7 0.9 1.5 -0.9 0.6 1.2 -1.2 -0.5
Qualifications: nursing, teaching 0.5 0.7 2.9 0.0 -0.7 0.3 -1.7 0.6
Commuting to job workplace: Walk 1.6 1.7 6.9 2.6 0.6 1.1 0.6 -0.0
Eye problems/disorders: Cataract 0.9 1.0 2.3 1.5 1.0 0.4 0.2 1.2
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 4.8 -0.4 -0.2 1.1 -1.6 2.2
Medication for cholesterol 0.1 0.2 0.5 0.7 -0.1 -0.1 0.5 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 0.0 0.3 -0.4 -0.6 0.6
Back pain experienced in last month 0.6 0.8 1.3 -1.1 -1.1 -1.1 0.1 -0.5
Mineral and other dietary supplements 0.7 1.0 3.1 -0.4 -1.7 -0.7 1.1 -0.1
Breast cancer (self-reported) 0.9 1.1 2.4 -0.1 1.5 0.8 -1.6 0.1
Asthma (self-reported) 0.6 1.1 3.3 -1.1 -1.8 0.9 -0.5 0.0
Osteoporosis (self-reported) 1.9 2.3 3.8 -1.5 -1.9 -1.5 -1.0 1.5
Osteoarthritis (self-reported) 0.2 0.2 0.4 0.4 0.3 0.3 -0.7 -0.5
Medication: Aspirin 0.5 0.7 1.6 0.8 1.3 1.0 0.2 0.4
Medication: Gliclazide 2.5 2.8 4.5 1.9 1.3 0.6 -1.9 2.1
Illnesses of father: None of the above (group 1) 0.6 0.7 1.9 -1.4 -0.9 -0.2 0.9 -0.3
Smoking status: Current 0.5 0.7 2.3 0.8 1.5 -0.0 0.7 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.9 -0.8 -0.5 -1.4 -0.6 -1.0
Whole body water mass 0.1 0.8 2.1 0.2 -1.4 1.4 0.2 -0.2
Leg predicted mass (right) 0.1 0.7 2.8 0.5 -0.3 1.7 0.5 -0.3
Arm fat mass (left) 0.3 1.1 4.9 0.1 -0.3 2.2 0.3 0.4
Number of self-reported non-cancer illnesses 0.7 1.3 3.9 -0.3 -0.2 2.0 -1.3 0.8
Average weekly champagne plus white wine intake 0.1 0.2 0.4 -0.1 -0.6 0.6 0.2 -0.2
Miserableness 1.5 2.5 5.6 -2.4 -1.8 -0.7 1.6 -0.9
Guilty feelings 2.0 3.0 9.0 -3.0 -2.2 0.5 0.6 -0.7
Wears glasses or contact lenses 0.3 0.4 1.1 -0.5 -0.4 0.1 -1.0 0.6
Ever taken oral contraceptive pill 0.4 0.5 1.2 -0.0 -0.2 1.0 -1.1 -0.4
Hearing aid user 0.8 0.9 1.5 0.6 0.5 1.2 1.0 1.1
Mother’s age at death 0.2 0.3 0.6 0.1 -0.8 0.8 -0.5 -0.3
Financial situation satisfaction 0.7 0.9 3.2 -0.6 0.4 1.8 0.6 -0.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.1 0.5 -1.3 -1.4 -0.8 0.3
Commuting to job workplace: Public transport 0.7 0.9 2.3 1.1 -0.1 0.4 1.5 0.9
Eye problems/disorders: Glaucoma 2.3 2.8 7.1 2.2 2.7 1.4 0.1 0.3
Medication: Blood pressure 0.2 0.3 0.8 0.5 0.9 0.6 0.6 -0.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.1 0.3 -1.5 0.0 -0.2 -0.4
Supplements: Fish oil (including cod liver oil) 1.0 1.4 2.2 0.3 1.4 0.9 -1.3 1.5
High cholesterol (Self-reported) 0.3 0.6 1.7 -1.3 -0.3 0.8 -0.2 -0.7
Medication: Bendroflumethiazide 0.6 0.9 2.1 0.2 0.4 1.0 1.4 -1.2
Medication: Paracetamol 1.5 2.4 5.9 -0.2 1.1 -2.4 1.7 -1.4
Medication: Lisinopril 0.9 1.2 3.8 1.0 1.9 1.1 0.0 -0.1
Medication: Atorvastatin 0.6 0.8 2.2 0.9 1.5 -0.1 0.6 0.6
Illnesses of father: High blood pressure 1.2 1.5 3.9 0.7 1.6 -0.0 -0.5 2.0
Alcohol drinker status: Never 0.7 0.9 2.0 -1.4 0.5 0.5 -0.2 1.3
Ever smoked 1.3 2.3 5.6 1.7 1.4 0.5 2.4 -0.9
Basal metabolic rate 0.1 0.8 2.2 0.2 -1.2 1.5 0.4 -0.1
Leg fat percentage (left) 0.5 1.9 6.6 -1.0 -0.8 2.6 -0.9 0.8
Arm fat-free mass (left) 0.2 1.2 2.9 -0.7 -1.7 1.7 -0.1 0.0
Number of operations (self-reported) 0.5 0.8 3.8 -0.2 -0.4 -0.2 0.0 2.0
Average weekly beer plus cider intake 0.5 0.7 2.8 -0.9 -1.7 0.3 0.2 0.1
Irritability 2.2 3.7 12.0 -2.1 -3.5 -1.0 0.9 -0.5
Risk taking 1.9 2.8 4.3 0.9 1.1 2.0 -2.1 2.0
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 -0.1 -0.3 0.3 -0.2 -0.6
Fractured/broken bones in last 5 years 0.7 0.9 4.0 0.8 2.0 -0.1 -0.2 -0.3
Age started oral contraceptive pill 0.9 1.1 4.9 0.6 -0.5 2.2 -0.3 -0.2
Diastolic blood pressure, automated reading 0.2 0.5 1.0 -0.6 -1.0 -1.0 0.2 0.5
Ever depressed for a whole week 2.0 2.5 5.6 -0.4 -0.2 -1.2 2.3 -2.4
Unable to work because of sickness or disability 1.2 1.5 5.2 -0.1 -0.1 2.3 -1.1 1.0
Commuting to job workplace: Cycle 1.0 1.2 3.6 1.0 1.9 1.0 0.2 -0.7
Myopia 0.4 0.5 1.5 -0.2 1.2 -0.5 0.8 -0.5
Vascular/heart problems diagnosed by doctor 0.8 2.3 5.6 -1.9 -2.4 -1.2 -0.8 -0.3
Cholesterol lowering medication 0.6 0.8 3.0 -0.3 -0.7 1.7 -0.6 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.6 -0.1 -0.0 0.8 0.8 0.2
Pain experienced in last month 0.5 0.8 1.8 -0.4 -1.2 1.3 -0.6 0.5
Supplements: Calcium 0.6 0.7 3.0 -0.0 0.5 0.5 -1.7 -0.1
Basal cell carcinoma (self-reported) 1.3 1.6 4.9 -1.1 -0.4 1.2 -2.2 0.3
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.7 -0.3 1.3 0.4 0.9 0.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.8 0.7 -1.3 -0.2 -0.5 1.3
Heart disease (siblings) 0.4 0.5 1.4 0.6 0.6 1.2 0.4 -0.8
Alcohol drinker status: Previous 1.2 1.3 3.7 1.9 1.4 0.6 -0.7 0.2
Pack years of smoking 0.9 1.3 5.4 -0.8 -2.3 0.2 -0.8 0.2
Impedance of whole body 0.3 1.7 7.5 -1.0 -0.1 -2.7 0.4 0.2
Leg fat mass (left) 0.4 1.6 6.5 -0.5 -0.8 2.5 -0.6 0.4
Arm predicted mass (left) 0.2 1.0 2.9 -0.3 -1.7 1.4 0.6 -0.1