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chr19:39,237,950-46,506,809

Best TWAS P=7.14e-24 · Best GWAS P=5.89e-111 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	YFS	Blood	PLAUR	0.14	0.06	bslmm	405	0.09	1.8e-26	-13.12	-10.1	7.1e-24	0.58	0.00	1.00	TRUE
64	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CKM	0.13	0.00	blup	38	0.05	2.2e-03	6.21	9.4	4.5e-21	0.00	0.01	0.40	TRUE
45	GTEx	Testis	MARK4	0.33	0.30	lasso	3	0.33	2.9e-15	8.73	-8.8	1.6e-18	0.01	1.00	0.00	TRUE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	APOC1	0.05	0.00	blup	47	0.01	4.3e-02	4.59	8.0	8.8e-16	0.02	0.01	0.13	TRUE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	PHLDB3	0.35	0.31	enet	16	0.39	3.4e-43	7.26	8.0	1.1e-15	-0.32	0.02	0.98	TRUE
100	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSK3A	0.15	0.10	lasso	7	0.09	4.0e-03	7.95	8.0	1.8e-15	-0.03	0.01	0.24	TRUE
26	GTEx	Muscle Skeletal	PINLYP	0.10	0.00	enet	13	0.02	7.3e-03	-5.05	-7.4	1.4e-13	0.37	0.53	0.03	TRUE
67	The Cancer Genome Atlas	Esophageal Carcinoma	ZNF575	0.21	0.18	lasso	4	0.15	1.7e-05	7.26	7.3	3.2e-13	-0.31	0.02	0.92	TRUE
79	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ERCC2	0.17	0.03	enet	20	0.05	5.3e-04	0.77	-7.0	3.0e-12	-0.04	0.02	0.36	TRUE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SUPT5H	0.05	0.04	blup	70	0.03	2.7e-04	-5.94	6.7	2.2e-11	-0.01	0.03	0.90	TRUE
30	GTEx	Nerve Tibial	ETHE1	0.09	0.05	enet	11	0.08	3.1e-06	-7.46	6.5	1.1e-10	-0.29	0.42	0.05	TRUE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ETHE1	0.09	0.08	blup	69	0.09	3.3e-10	-7.41	6.3	2.5e-10	-0.24	0.00	1.00	TRUE
4	GTEx	Adipose Subcutaneous	C19orf54	0.22	0.05	lasso	8	0.09	8.0e-08	-4.68	5.7	1.1e-08	0.00	0.34	0.64	TRUE
49	GTEx	Testis	SMG9	0.34	0.26	enet	8	0.26	4.0e-12	5.43	-5.5	3.1e-08	-0.10	1.00	0.00	TRUE
105	The Cancer Genome Atlas	Thyroid Carcinoma	PVRL2	0.09	0.05	blup	55	0.03	4.6e-04	-2.37	5.4	8.0e-08	-0.03	0.48	0.06	TRUE
38	GTEx	Skin Sun Exposed Lower leg	PVR	0.11	0.05	lasso	2	0.06	2.1e-05	5.39	5.3	9.3e-08	-0.11	0.58	0.31	TRUE
5	GTEx	Adrenal Gland	ZNF221	0.23	0.01	enet	13	0.02	6.8e-02	4.81	-5.3	1.0e-07	0.25	0.07	0.05	TRUE
43	GTEx	Skin Sun Exposed Lower leg	PHLDB3	0.16	0.09	lasso	9	0.12	2.4e-10	7.26	8.9	5.8e-19	-0.38	0.99	0.01	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	CKM	0.11	0.08	blup	38	0.07	1.1e-04	-3.42	8.7	2.3e-18	-0.05	0.02	0.94	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHLDB3	0.09	0.08	lasso	3	0.08	1.6e-16	-7.49	8.4	5.2e-17	-0.33	0.00	1.00	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	ETHE1	0.13	0.06	lasso	3	0.05	1.0e-03	-7.46	7.7	1.4e-14	-0.30	0.26	0.04	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PHLDB3	0.14	0.04	blup	58	0.09	3.9e-10	3.95	7.7	1.7e-14	-0.27	0.01	0.99	FALSE
42	GTEx	Skin Sun Exposed Lower leg	ETHE1	0.09	0.07	enet	8	0.07	2.7e-06	-7.46	7.6	3.4e-14	-0.32	0.97	0.00	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	PAFAH1B3	0.02	0.01	blup	16	0.02	6.7e-03	6.69	7.6	3.4e-14	-0.01	0.01	0.71	FALSE
17	GTEx	Esophagus Mucosa	ETHE1	0.21	0.10	lasso	4	0.08	5.6e-06	-7.49	7.6	3.9e-14	-0.29	0.91	0.00	FALSE
24	GTEx	Muscle Skeletal	ETHE1	0.06	0.06	lasso	2	0.03	2.9e-04	-7.49	7.5	5.5e-14	-0.29	0.60	0.04	FALSE
84	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ETHE1	0.08	0.08	enet	9	0.07	3.0e-04	-7.49	7.5	7.4e-14	-0.30	0.00	0.95	FALSE
9	GTEx	Artery Tibial	PINLYP	0.26	0.23	lasso	6	0.25	2.1e-19	-4.78	-7.5	9.2e-14	0.38	1.00	0.00	FALSE
16	GTEx	Colon Transverse	PINLYP	0.21	0.01	enet	19	0.06	1.1e-03	-5.05	-7.5	9.3e-14	0.34	0.57	0.02	FALSE
41	GTEx	Skin Sun Exposed Lower leg	MEGF8	0.05	0.01	enet	11	0.00	1.2e-01	6.03	-7.4	1.3e-13	0.00	0.02	0.84	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	CKM	0.03	0.03	lasso	2	0.03	2.1e-06	-8.04	7.3	2.6e-13	0.00	0.32	0.67	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	ETHE1	0.12	0.11	enet	10	0.12	6.1e-14	-7.46	7.3	3.1e-13	-0.31	0.00	1.00	FALSE
69	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DEDD2	0.02	0.02	lasso	1	0.01	3.1e-02	7.27	-7.3	3.5e-13	0.00	0.06	0.72	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	PHLDB3	0.14	0.13	lasso	1	0.10	3.8e-06	7.26	7.3	3.9e-13	-0.31	0.83	0.01	FALSE
47	GTEx	Testis	MEGF8	0.13	0.07	lasso	12	0.04	8.1e-03	7.18	-7.2	5.9e-13	0.01	0.09	0.34	FALSE
48	GTEx	Testis	GRIK5	0.41	0.24	lasso	10	0.24	7.9e-11	7.26	-7.1	1.4e-12	0.00	1.00	0.00	FALSE
50	GTEx	Testis	PHLDB3	0.43	0.07	lasso	9	0.24	5.7e-11	3.95	7.1	1.4e-12	-0.27	0.90	0.03	FALSE
12	GTEx	Breast Mammary Tissue (Male)	PINLYP	0.34	0.06	enet	2	0.07	1.0e-02	-7.46	-7.0	1.8e-12	0.28	0.12	0.06	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	CKM	0.05	0.04	blup	38	0.06	2.1e-07	-4.21	7.0	3.2e-12	-0.01	0.13	0.86	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	APOE	0.06	0.00	blup	49	0.01	4.5e-02	4.59	6.9	4.2e-12	0.03	0.02	0.07	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CKM	0.06	0.03	blup	39	0.06	5.2e-07	-2.65	6.9	5.3e-12	-0.02	0.20	0.79	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	PHLDB3	0.09	0.05	blup	58	0.06	3.1e-07	3.95	6.9	7.0e-12	-0.26	0.09	0.91	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	CKM	0.06	0.02	blup	38	0.04	9.1e-06	-8.04	6.8	7.1e-12	-0.01	0.32	0.57	FALSE
53	GTEx	Thyroid	PINLYP	0.14	0.08	lasso	6	0.11	6.1e-09	-4.83	-6.8	7.4e-12	0.35	0.99	0.00	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GSK3A	0.03	0.00	blup	20	0.01	1.4e-02	6.99	6.8	8.5e-12	0.01	0.00	0.40	FALSE
22	GTEx	Liver	ETHE1	0.21	0.19	lasso	3	0.16	2.4e-05	-7.46	6.7	1.5e-11	-0.30	0.37	0.09	FALSE
3	GTEx	Adipose Subcutaneous	ETHE1	0.18	0.16	lasso	6	0.19	1.0e-15	-7.41	6.7	1.7e-11	-0.29	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF574	0.02	0.01	lasso	2	0.02	1.1e-04	-3.87	6.7	2.8e-11	0.01	0.01	0.31	FALSE
6	GTEx	Artery Aorta	ETHE1	0.20	0.12	lasso	6	0.14	4.9e-08	-7.46	6.6	3.2e-11	-0.30	0.98	0.00	FALSE
14	GTEx	Colon Sigmoid	PINLYP	0.39	0.13	lasso	11	0.24	6.5e-09	1.68	-6.6	3.9e-11	0.36	0.80	0.01	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	PHLDB3	0.32	0.07	enet	21	0.15	4.2e-14	3.95	6.6	4.0e-11	-0.21	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	APOC1P1	0.03	0.00	blup	37	0.01	1.5e-02	2.86	6.5	6.2e-11	0.04	0.01	0.16	FALSE
66	The Cancer Genome Atlas	Colon Adenocarcinoma	PHLDB3	0.14	0.05	blup	58	0.10	3.4e-06	3.95	6.5	7.6e-11	-0.25	0.01	0.89	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PHLDB3	0.04	0.04	lasso	2	0.04	4.4e-04	7.26	6.5	8.5e-11	-0.29	0.03	0.71	FALSE
21	GTEx	Heart Left Ventricle	ETHE1	0.21	0.14	enet	24	0.12	7.8e-07	-7.41	6.5	8.9e-11	-0.29	0.84	0.03	FALSE
33	GTEx	Nerve Tibial	PINLYP	0.33	0.12	lasso	4	0.26	4.0e-18	1.68	-6.5	9.0e-11	0.31	1.00	0.00	FALSE
23	GTEx	Lung	LIPE	0.28	0.03	lasso	4	0.04	4.3e-04	6.03	6.5	1.1e-10	-0.02	0.57	0.06	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	ETHE1	0.11	0.14	lasso	7	0.14	2.3e-14	-7.54	6.4	1.3e-10	-0.26	0.00	1.00	FALSE
8	GTEx	Artery Tibial	ETHE1	0.21	0.06	enet	19	0.14	2.9e-11	1.63	6.4	1.9e-10	-0.27	1.00	0.00	FALSE
10	GTEx	Brain Cerebellar Hemisphere	PINLYP	0.33	0.20	lasso	10	0.18	2.3e-05	1.73	-6.3	3.0e-10	0.33	0.28	0.54	FALSE
19	GTEx	Esophagus Muscularis	ETHE1	0.09	0.12	lasso	2	0.09	2.9e-06	-7.46	6.2	7.2e-10	-0.23	0.95	0.01	FALSE
13	GTEx	Cells Transformed fibroblasts	PINLYP	0.29	0.13	lasso	5	0.21	5.1e-16	-5.05	-6.2	7.6e-10	0.33	1.00	0.00	FALSE
15	GTEx	Colon Transverse	SUPT5H	0.09	0.09	enet	10	0.02	4.4e-02	6.06	-6.0	1.4e-09	0.05	0.02	0.96	FALSE
56	YFS	Blood	CNFN	0.01	0.01	lasso	4	0.01	1.7e-04	6.20	-6.0	1.5e-09	0.02	0.55	0.02	FALSE
91	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CKM	0.10	0.02	blup	39	0.07	3.1e-05	-2.06	6.0	2.0e-09	0.01	0.04	0.51	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIPE	0.02	0.01	blup	19	0.01	3.6e-02	6.20	6.0	2.2e-09	-0.02	0.01	0.71	FALSE
106	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PHLDB3	0.18	0.06	blup	57	0.10	8.3e-04	1.65	6.0	2.3e-09	-0.27	0.02	0.74	FALSE
88	The Cancer Genome Atlas	Lung Adenocarcinoma	ETHE1	0.07	0.04	blup	68	0.04	1.9e-05	-7.46	6.0	2.7e-09	-0.27	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	APOC1	0.06	0.05	enet	8	0.06	4.6e-07	3.32	5.9	2.8e-09	0.04	0.74	0.04	FALSE
39	GTEx	Skin Sun Exposed Lower leg	XRCC1	0.07	0.01	lasso	1	0.00	3.8e-01	-5.93	5.9	3.1e-09	-0.24	0.06	0.04	FALSE
46	GTEx	Testis	TIMM50	0.28	0.29	lasso	3	0.33	4.3e-15	6.03	5.9	4.5e-09	-0.03	0.02	0.98	FALSE
44	GTEx	Skin Sun Exposed Lower leg	SUPT5H	0.07	0.08	enet	8	0.08	2.9e-07	6.14	5.8	8.6e-09	-0.04	0.02	0.98	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	MARK4	0.03	0.01	lasso	2	0.03	2.0e-06	-2.08	5.7	1.1e-08	-0.04	0.42	0.21	FALSE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	XRCC1	0.11	0.05	blup	75	0.07	1.3e-05	4.90	-5.7	1.1e-08	0.25	0.65	0.02	FALSE
51	GTEx	Thyroid	PHLDB3	0.15	0.04	enet	12	0.06	3.7e-05	-7.41	5.7	1.2e-08	-0.23	0.56	0.02	FALSE
35	GTEx	Pancreas	PHLDB3	0.26	0.19	lasso	2	0.25	4.0e-11	3.95	5.7	1.3e-08	-0.26	0.97	0.00	FALSE
68	The Cancer Genome Atlas	Glioblastoma Multiforme	ITPKC	0.11	0.00	blup	67	0.04	1.7e-02	5.37	5.7	1.3e-08	0.01	0.01	0.75	FALSE
95	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKM	0.03	0.01	blup	38	0.02	3.3e-03	-4.21	5.6	2.0e-08	-0.01	0.05	0.20	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APOC1P1	0.05	0.03	blup	37	0.03	5.2e-04	-4.60	5.6	2.7e-08	0.04	0.06	0.67	FALSE
40	GTEx	Skin Sun Exposed Lower leg	ITPKC	0.07	0.07	enet	8	0.07	1.0e-06	-5.12	5.5	2.8e-08	0.02	0.00	1.00	FALSE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADCK4	0.09	0.11	lasso	4	0.12	1.9e-12	-5.12	5.5	2.8e-08	0.02	0.05	0.95	FALSE
55	GTEx	Whole Blood	CTB-129P6.4	0.53	0.49	enet	26	0.50	2.3e-53	5.82	5.5	2.9e-08	-0.02	1.00	0.00	FALSE
7	GTEx	Artery Aorta	PINLYP	0.29	0.10	lasso	8	0.15	8.6e-09	-4.83	-5.5	3.4e-08	0.28	0.96	0.00	FALSE
11	GTEx	Breast Mammary Tissue	PINLYP	0.20	0.06	lasso	8	0.11	2.9e-06	-5.05	-5.5	3.4e-08	0.29	0.75	0.04	FALSE
28	GTEx	Nerve Tibial	ITPKC	0.11	0.07	enet	6	0.07	1.7e-05	-5.12	5.5	3.7e-08	0.03	0.00	1.00	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	C19orf54	0.06	0.03	blup	61	0.04	3.7e-05	5.51	5.5	3.7e-08	-0.08	0.01	0.95	FALSE
101	The Cancer Genome Atlas	Rectum Adenocarcinoma	XRCC1	0.12	0.07	blup	76	0.05	2.2e-02	-4.62	-5.5	4.4e-08	0.23	0.02	0.30	FALSE
25	GTEx	Muscle Skeletal	SMG9	0.13	0.10	enet	8	0.10	1.1e-09	5.33	5.4	5.4e-08	0.10	1.00	0.00	FALSE
54	GTEx	Whole Blood	PVRL2	0.60	0.58	lasso	6	0.61	3.6e-71	5.82	5.4	6.5e-08	-0.01	1.00	0.00	FALSE
31	GTEx	Nerve Tibial	ADCK4	0.22	0.23	lasso	3	0.24	7.7e-17	4.70	5.4	7.1e-08	-0.02	0.28	0.71	FALSE
34	GTEx	Pancreas	ETHE1	0.33	0.19	enet	20	0.22	1.3e-09	-7.46	5.3	8.9e-08	-0.20	0.98	0.00	FALSE
27	GTEx	Nerve Tibial	XRCC1	0.14	0.01	lasso	8	0.03	1.8e-03	-4.83	5.3	1.1e-07	-0.29	0.61	0.02	FALSE
93	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ETHE1	0.11	0.02	blup	69	0.08	4.2e-04	-7.54	5.3	1.3e-07	-0.25	0.01	0.91	FALSE
59	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SUPT5H	0.03	0.00	blup	70	0.01	7.0e-02	-2.69	5.2	1.9e-07	-0.06	0.02	0.69	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C19orf54	0.06	0.02	bslmm	432	0.02	6.6e-04	5.51	5.2	2.0e-07	-0.02	0.02	0.95	FALSE
18	GTEx	Esophagus Mucosa	PHLDB3	0.30	0.17	lasso	5	0.23	2.6e-15	1.65	5.2	2.0e-07	-0.24	1.00	0.00	FALSE
20	GTEx	Esophagus Muscularis	PINLYP	0.20	0.12	lasso	9	0.14	4.7e-09	-5.03	-5.2	2.1e-07	0.29	0.99	0.00	FALSE
32	GTEx	Nerve Tibial	C19orf54	0.21	0.06	enet	28	0.10	1.2e-07	4.58	5.2	2.1e-07	-0.01	0.39	0.60	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB4B	0.07	0.04	blup	57	0.05	2.0e-06	-3.25	5.2	2.1e-07	-0.02	0.65	0.20	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PVR	0.22	0.17	enet	26	0.17	2.3e-20	5.39	5.2	2.5e-07	-0.14	0.55	0.45	FALSE
29	GTEx	Nerve Tibial	NUMBL	0.10	0.03	enet	18	0.04	8.8e-04	-4.74	5.2	2.5e-07	0.01	0.02	0.96	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	ITPKC	0.11	0.11	lasso	5	0.09	2.1e-09	-5.12	5.2	2.5e-07	0.03	0.07	0.93	FALSE
52	GTEx	Thyroid	C19orf54	0.26	0.09	enet	19	0.19	8.0e-15	-4.68	5.1	2.7e-07	0.01	0.28	0.71	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PVR	0.08	0.10	lasso	4	0.09	9.8e-11	5.05	5.1	2.8e-07	-0.11	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	PLEKHG2	0.03	0.03	blup	52	0.03	2.9e-04	6.27	-5.1	2.8e-07	0.03	0.01	0.97	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C19orf61	0.06	0.06	lasso	4	0.05	9.3e-07	5.33	5.1	2.9e-07	0.10	0.02	0.98	FALSE