TWAS hub - COMT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.4940	0.0830	3.2e-06	0.004	NA	0.252	NA	0.212	2.2e-01	NA	2.0e-09	NA	4.8e-08
2	GTEx	Esophagus Mucosa	0.2410	0.0750	4.9e-04	0.152	NA	0.120	NA	0.131	2.3e-10	NA	2.1e-08	NA	4.8e-09
3	GTEx	Muscle Skeletal	0.1153	0.0407	3.7e-03	0.008	NA	0.011	NA	0.009	4.4e-02	NA	2.4e-02	NA	3.6e-02
4	GTEx	Testis	0.1890	0.0690	2.4e-03	-0.001	NA	0.005	NA	-0.006	3.5e-01	NA	1.9e-01	NA	8.6e-01
5	METSIM	Adipose	0.0829	0.0320	4.8e-04	0.017	0.018	0.017	0.019	0.011	1.2e-03	8.2e-04	1.1e-03	5.3e-04	7.7e-03
6	YFS	Blood	0.0481	0.0132	1.4e-06	0.007	0.021	0.019	0.025	0.014	1.6e-03	1.5e-07	6.4e-07	7.7e-09	1.1e-05
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0840	0.0360	1.3e-03	0.094	0.059	0.072	NA	0.080	5.1e-06	2.6e-04	6.1e-05	NA	2.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Falls in the last year	3.9	5.3	14.6	1.1	3.8	-0.1	-1.9	-2.7	2.6	-1.9
Angina	3.1	4.1	13.9	-1.3	3.7	2.1	0.4	-1.9	2.2	-0.5
Nervous feelings	2.8	5.3	10.3	-2.2	-2.4	1.3	2.3	3.0	-3.2	0.4
Angina (self-reported)	2.8	3.6	12.2	-1.1	3.5	2.1	0.4	-1.8	1.9	-0.6
Medication: Gliclazide	2.7	3.1	9.2	-0.5	2.2	-0.8	-1.3	-3.0	2.1	-0.4
Commuting to job workplace: Cycle	2.6	3.2	7.9	-1.3	2.8	1.4	0.1	-1.4	2.8	0.9
Neuroticism (2016)	2.4	3.5	11.5	0.8	-3.4	1.0	-1.8	2.8	-0.1	0.2
Cardiovascular Disease	2.4	7.8	18.4	1.6	4.3	-0.8	-1.9	-3.8	2.9	-2.5
Impedance of arm (right)	2.4	11.4	18.7	-3.3	-3.9	0.1	3.6	4.3	-3.9	2.6
Type 2 Diabetes (T2D) (2018)	2.3	4.4	11.7	1.3	2.8	-0.6	-0.3	-2.9	3.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	7.4	0.8	-1.0	1.2	-1.3	0.7	2.2	2.7
Medication: Bendroflumethiazide	2.3	3.4	6.2	2.3	1.4	-2.0	-1.6	-2.0	0.2	-2.5
Alzheimer’s Disease (including proxy)	2.2	3.2	8.6	-2.2	0.1	0.7	-1.6	2.0	1.3	2.9
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	6.6	-0.3	-2.6	1.9	0.7	2.1	-0.5	1.8
Back pain experienced in last month	2.2	3.2	15.3	1.8	1.2	-0.6	-0.3	-1.1	0.9	-3.9
Alzheimer’s Disease (in father)	2.1	2.3	7.7	-2.8	0.4	0.5	-0.8	1.3	0.8	2.3
Mean Putamen Volume	2.1	2.4	6.5	-0.9	0.4	2.6	1.0	1.9	0.9	1.9
Hair/balding pattern: Pattern 4	2.1	5.1	13.0	0.3	2.5	-2.2	2.3	-3.6	0.7	-2.3
Number of self-reported non-cancer illnesses	2.1	3.6	10.8	-1.1	3.3	-0.2	-1.6	-1.2	3.0	0.1
Impedance of whole body	2.1	10.5	19.1	-3.0	-4.0	0.2	3.0	4.4	-3.9	2.3
Worry (Nagel 2018)	2.0	4.2	13.3	-1.1	-3.6	1.1	0.9	2.6	-2.5	0.5
Impedance of leg (right)	2.0	9.6	21.8	-2.4	-3.6	1.1	2.9	4.7	-3.5	2.3
Medication: Simvastatin	2.0	2.9	5.4	1.0	2.3	-0.9	-1.9	-2.0	1.7	-1.7
Impedance of arm (left)	2.0	9.3	17.6	-3.1	-4.2	0.5	2.3	4.1	-3.0	2.6
Medication: Seretide 50 evohaler	2.0	2.3	6.6	0.2	-2.6	1.4	1.1	0.6	0.5	2.4
Risk taking	2.0	2.9	5.3	1.9	1.1	-0.4	-2.3	-1.8	2.0	-1.6
Cholesterol lowering medication	2.0	3.0	6.2	1.0	1.9	-2.2	-1.5	-1.6	0.7	-2.5
Suffer from ‘nerves’	1.9	3.0	9.6	1.2	-2.1	0.4	1.2	3.1	-1.8	-0.5
Long-standing illness, disability or infirmity	1.9	3.0	11.8	1.1	3.4	-0.9	-0.5	-0.5	2.5	-0.5
Medication for cholesterol	1.9	2.9	6.3	-0.7	-1.1	2.2	1.7	2.2	0.5	2.5
Heart disease (siblings)	1.9	2.3	4.2	1.2	1.6	-0.5	-2.0	-2.0	1.8	-0.8
Blood White Count	1.8	13.1	36.8	0.6	5.3	0.1	0.5	-6.1	4.0	-3.1
Systolic blood pressure, automated reading	1.8	5.4	15.4	0.7	3.8	-1.7	0.2	-3.9	1.6	-1.2
Illnesses of mother	1.8	2.2	6.7	-1.3	0.8	-0.8	2.6	-1.2	-2.2	-0.2
Systolic Blood Pressure	1.7	8.7	21.7	2.0	4.1	-2.6	-0.9	-4.7	2.3	-2.4
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	6.2	1.1	1.6	-1.3	-1.6	-2.5	0.8	-0.9
Loud music exposure frequency	1.7	1.8	4.9	-2.2	0.6	1.2	0.4	2.2	0.6	0.8
Arm predicted mass (right)	1.7	8.8	17.8	2.8	4.2	-0.6	-3.5	-3.4	2.4	-2.4
Breast cancer (self-reported)	1.7	2.1	3.9	0.5	-1.7	2.0	1.4	1.8	-0.5	1.3
Coronary Artery Disease (CAD)	1.6	1.9	4.4	0.9	2.1	0.4	1.2	-1.6	1.8	0.7
BMI	1.6	9.4	22.4	0.8	4.7	0.4	-2.1	-4.3	4.3	-0.9
Townsend deprivation index at recruitment	1.6	2.2	7.8	0.3	1.6	-1.2	-1.0	-0.3	2.8	-1.6
Impedance of leg (left)	1.6	8.0	15.5	-2.2	-3.0	0.3	3.2	3.9	-3.6	1.6
Arm fat-free mass (right)	1.6	8.2	16.1	2.5	4.0	-0.6	-3.5	-3.4	2.5	-2.2
Chest pain or discomfort	1.6	2.3	8.3	0.6	2.0	0.8	-1.4	-1.1	2.9	0.1
High cholesterol (Self-reported)	1.6	2.9	9.7	0.1	2.7	-0.3	-1.5	-0.6	3.1	-0.4
Medication: Atorvastatin	1.6	2.0	6.3	0.7	2.5	-0.0	1.4	-0.7	2.0	-0.6
Alcohol drinker status: Never	1.6	2.0	6.6	0.2	1.0	-2.0	-0.6	-0.7	-1.2	-2.6
Relative age voice broke	1.5	2.3	4.8	1.6	0.8	-1.2	2.2	-2.2	-0.3	-1.3
Chronic bronchitis/emphysema (father)	1.5	1.7	3.8	-1.6	-0.3	1.4	1.9	1.3	-0.8	1.1
Number of incorrect matches in round	1.5	2.4	7.6	-1.5	-2.8	1.0	0.7	1.6	-1.2	1.2
Length of working week for main job	1.5	1.6	4.7	2.2	-0.6	-1.0	-1.6	0.5	-0.2	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	7.8	1.6	-1.1	0.8	-0.5	1.2	2.8	1.5
Medication: Blood pressure	1.5	2.6	5.2	0.5	2.1	0.6	-1.5	-2.1	2.3	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.5	2.5	5.4	-0.3	1.6	-2.1	-1.8	-1.2	2.3	0.1
Financial situation satisfaction	1.5	1.9	6.9	-0.8	-1.0	-0.1	-1.1	2.6	1.2	1.4
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.1	-0.3	1.8	0.1	-1.8	-1.7	1.8	-1.1
Alcohol drinker status: Previous	1.5	1.7	6.1	1.4	-0.2	-2.5	0.5	-0.5	1.3	-1.2
Arm predicted mass (left)	1.5	7.4	18.8	2.3	4.3	-0.8	-2.8	-3.1	1.9	-2.4
Triglycerides	1.4	2.3	7.1	0.9	2.0	-1.6	-0.4	-2.7	0.1	-1.1
Chronotype (morning person)	1.4	3.3	7.0	-2.6	0.9	-2.2	-1.6	-0.9	-2.2	-1.4
Hair/balding pattern: Pattern 3	1.4	2.0	4.8	-0.3	1.3	-1.7	-1.5	-1.5	0.2	-2.2
Medication: Cholesterol lowering	1.4	2.2	7.7	-0.4	2.8	-0.1	-0.2	-0.8	2.6	-0.2
Pulse wave Arterial Stiffness index	1.4	1.7	4.4	-0.7	2.1	1.9	-0.1	-0.8	1.5	0.1
Trunk predicted mass	1.4	7.8	20.2	2.1	4.5	-0.8	-3.5	-2.7	2.0	-2.4
Pulse wave peak to peak time	1.4	1.7	4.6	0.6	-2.1	-2.1	-0.1	0.8	-1.4	0.1
Neck or shoulder pain in last month	1.4	2.0	6.6	-0.1	2.0	-0.4	-1.3	-1.2	2.6	-0.4
Migraine (self-reported)	1.4	1.7	6.2	-0.1	-1.0	0.2	1.2	2.5	-1.9	-0.0
Hypertension (Self-reported)	1.4	3.8	10.3	1.2	3.2	-0.8	-1.2	-2.6	1.6	-2.0
Whole body fat-free mass	1.4	7.7	17.7	2.2	4.2	-0.9	-3.3	-3.2	2.2	-2.2
Leg fat-free mass (right)	1.4	7.4	15.2	1.9	3.9	-1.1	-2.9	-3.9	2.0	-2.2
Medication: Blood pressure	1.4	2.6	7.4	1.1	2.2	-1.6	-0.8	-1.4	-0.0	-2.7
Arm fat-free mass (left)	1.4	7.1	18.1	2.4	4.2	-0.6	-2.7	-3.0	2.1	-2.1
Fractured/broken bones in last 5 years	1.4	1.8	3.0	1.5	0.0	-1.6	-1.5	-1.7	1.6	-0.1
Vascular/heart problems diagnosed by doctor	1.4	3.8	10.1	-0.7	-3.2	0.2	1.6	2.7	-1.6	1.9
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.1	-0.3	1.2	-1.1	0.7	-2.0	-0.7	-1.6
Blood Platelet Count	1.3	14.9	44.9	1.0	5.7	0.2	1.0	-4.9	6.7	-1.4
High blood pressure	1.3	3.7	8.5	1.0	2.9	-0.7	-1.8	-2.6	1.7	-1.8
High blood pressure (mother)	1.3	1.9	4.2	1.4	0.9	-2.1	-0.7	-1.3	0.9	-1.7
Waist circumference	1.3	4.9	12.0	1.3	2.8	0.9	-1.8	-3.0	3.5	-0.5
Diabetes (self-reported)	1.3	2.0	7.2	0.9	1.5	-0.8	-0.1	-1.6	2.7	-0.5
Trunk fat-free mass	1.3	7.6	19.2	2.1	4.4	-0.8	-3.5	-2.7	2.0	-2.2
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	7.0	-0.0	-2.1	-0.8	0.9	1.4	-2.7	-0.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	7.9	-0.5	-0.7	2.8	-0.6	0.4	0.6	1.6
Had major operations	1.3	1.5	6.6	2.6	-0.4	-0.2	0.8	-0.2	-0.9	-1.5
Whole body water mass	1.3	7.5	17.0	2.3	4.1	-0.9	-3.2	-3.2	2.0	-2.3
Leg predicted mass (right)	1.3	7.1	14.5	1.9	3.8	-1.1	-2.8	-3.8	1.9	-2.2
Basal metabolic rate	1.3	7.0	16.5	1.9	4.1	-0.7	-3.1	-3.2	2.1	-2.1
HbA1C	1.2	1.4	4.2	-0.8	2.1	-1.0	-0.6	-1.1	1.4	-0.5
Lupus	1.2	1.8	4.1	-1.7	-0.7	-1.5	1.1	1.0	-2.0	0.8
Medication: Atenolol	1.2	1.5	2.4	1.3	0.8	-0.8	1.5	-1.5	1.1	-1.4
Pain all over the body in last month	1.2	1.3	4.9	0.7	2.2	-0.2	-0.2	-0.3	1.7	-0.7
Exposure to tobacco smoke at home	1.2	1.3	3.8	1.9	-0.9	1.6	-0.0	0.5	1.2	-0.6
Eye problems/disorders: None of the above	1.2	1.4	3.6	-0.9	0.9	1.6	0.2	0.7	1.2	1.9
Number of operations (self-reported)	1.2	1.8	3.4	1.9	1.2	-1.5	0.2	-1.7	0.6	-1.4
Bipolar Disorder (2018)	1.1	1.7	3.4	-0.9	-1.0	-1.8	1.4	0.3	-1.3	-1.6
Verbal and Numeric Reasoning (VNR)	1.1	2.6	10.7	-1.3	3.3	0.8	1.3	-1.6	-0.0	0.8
Primary Biliary Cirrhosis	1.1	1.5	3.4	-1.8	-1.2	-0.8	1.1	0.4	-0.5	1.9
Medication for hormone replacement therapy	1.1	1.2	5.4	-0.4	-0.2	-0.9	-1.2	-2.3	0.7	0.1
Leg fat-free mass (left)	1.1	6.1	11.8	1.7	3.4	-0.6	-3.0	-3.4	2.0	-1.7
Leg predicted mass (left)	1.1	5.8	10.7	1.8	3.3	-0.7	-2.9	-3.3	1.9	-1.8
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.6	1.3	-0.6	0.5	0.7	1.5	1.9	0.9
Hip circumference	1.1	4.9	9.9	1.9	2.7	0.4	-2.7	-2.4	3.1	-0.4
Exposure to tobacco smoke outside home	1.1	1.5	4.9	0.7	1.6	-0.3	-0.5	-1.3	2.2	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.1	0.7	1.7	-0.4	-1.5	-1.1	1.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.1	-1.6	-0.0	0.9	0.2	2.0	-0.0	1.3
Eye problems/disorders: Glaucoma	1.1	1.3	5.5	1.0	-0.1	-1.0	-0.5	-0.3	-1.0	-2.3
Number of treatments/medications taken	1.0	1.8	5.8	-0.4	2.2	-0.3	-0.5	-1.2	2.4	-0.0
Diabetes (mother)	1.0	1.3	5.0	0.7	1.1	0.4	-0.3	-1.3	2.2	-0.2
Body mass index (BMI)	1.0	4.3	8.9	1.2	2.9	0.8	-1.5	-3.0	2.9	-1.0
Fluid intelligence score	1.0	2.2	7.0	-0.0	2.7	-1.9	-0.1	-2.0	-0.7	-0.1
Weight	1.0	5.1	12.9	1.3	3.6	-0.1	-2.1	-3.2	2.1	-1.5
Time employed in main current job	1.0	1.1	3.9	2.0	-0.6	-0.4	-0.3	-0.3	-0.2	-1.8
Pulse rate	1.0	1.7	5.1	0.7	-1.8	-0.9	-2.2	1.0	-0.3	1.1
Depression (self-reported)	1.0	1.2	2.8	1.6	-0.4	0.5	-1.4	0.6	1.7	0.1
Tense / ‘highly strung’	1.0	1.6	4.6	0.4	-2.1	1.4	0.1	2.0	-0.8	-0.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.4	1.4	-2.1	-0.3	-1.6	-0.2	-0.1	0.1
Emphysema/chronic bronchitis	1.0	1.1	2.0	-1.4	0.4	1.1	1.4	0.2	1.4	0.9
Number of full sisters	1.0	1.2	2.4	1.5	1.1	-1.6	0.7	-0.9	0.3	-1.1
Diabetes diagnosed by doctor	1.0	1.7	4.7	0.9	1.5	-0.7	-0.0	-1.8	2.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	3.5	0.7	1.9	0.9	-1.2	-0.6	1.0	0.6
Myopia	1.0	1.5	6.4	-0.5	-0.6	-0.8	0.5	2.5	-1.6	0.3
Pain experienced in last month	1.0	1.7	3.8	0.2	-1.4	0.9	0.9	0.5	-2.0	1.9
Intelligence (Savage-Jansen 2018)	0.9	2.9	14.8	-0.1	3.8	-0.8	0.8	-1.9	-0.2	-0.8
Ulcerative Colitis (UC)	0.9	1.6	5.3	-2.3	0.5	-0.0	1.8	-1.1	1.1	0.6
Age at First Birth	0.9	1.4	3.2	-1.5	1.3	-1.8	-0.1	0.1	-1.3	-0.8
LDL Cholesterol	0.9	1.4	3.7	0.5	0.8	-0.2	-1.4	-1.9	1.9	0.1
Blood Eosinophil Count	0.9	6.8	19.4	-0.3	2.0	0.7	-2.1	-4.4	4.4	0.4
Average weekly fortified wine intake	0.9	1.0	3.0	1.1	1.0	-1.3	-0.0	-0.3	-0.0	-1.7
Had menopause	0.9	1.2	2.9	-0.3	-1.0	1.7	1.0	0.3	-0.5	1.6
Financial difficulties in last 2 years	0.9	1.2	2.9	0.3	1.4	-0.5	-0.5	-0.3	1.6	-1.7
Illnesses of siblings	0.9	1.2	2.4	1.0	-1.4	-0.3	1.0	1.5	-1.5	-0.4
Neuroticism score	0.9	1.9	6.5	0.2	-2.0	1.5	0.2	2.6	-0.4	-0.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	4.1	0.3	0.5	2.0	-0.6	-0.3	1.5	0.5
High blood pressure (siblings)	0.9	1.3	2.6	-0.9	1.6	-0.4	-1.6	-1.2	1.3	0.1
Worry too long after embarrassment	0.9	1.5	3.2	-1.0	-0.6	1.4	-1.2	1.3	0.7	1.8
Medication for pain relief, constipation, heartburn	0.9	1.5	4.4	1.8	-1.2	-0.6	-0.6	-0.3	-2.1	-0.7
Heart disease (mother)	0.9	1.1	2.8	1.4	-0.8	1.7	-1.1	0.9	0.3	0.3
Smoking status: Previous	0.9	1.3	4.6	1.2	-0.7	0.4	-2.1	-0.5	0.7	1.2
Eye problems/disorders: Cataract	0.9	1.0	4.6	-0.3	-2.1	-1.1	-0.0	0.8	-0.7	-0.3
Medication: Lisinopril	0.9	1.2	2.9	1.7	-1.0	-1.6	-0.3	-0.0	-0.6	-1.2
Fasting Glucose	0.8	1.0	2.6	-0.7	1.1	0.6	-0.4	-1.6	1.4	0.4
Sensitivity / hurt feelings	0.8	1.3	2.9	-0.2	-1.6	1.6	0.7	1.7	-0.5	0.7
Diabetes (father)	0.8	1.0	2.9	-0.9	0.7	-0.4	0.4	-1.4	1.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.8	2.0	0.5	-0.1	-1.6	0.2	0.6	-1.0
Happiness	0.8	1.0	2.5	-1.6	-0.0	-1.4	-0.6	1.4	-0.0	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.9	1.4	-1.1	-0.1	-1.7	1.1	0.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.2	-1.4	-1.5	0.6	0.8	0.6	-1.0	0.4
Leg pain on walking	0.8	1.0	2.8	-0.4	1.5	0.7	1.7	-0.6	0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.8	1.0	0.1	-1.1	1.1	-0.5	-1.4	-1.0
Knee pain experienced in last month	0.8	1.3	3.2	-0.2	0.8	-0.9	-1.3	-1.6	-0.1	-1.8
Loneliness, isolation	0.8	1.1	4.5	1.5	-0.0	-0.7	-0.6	-0.1	-0.2	-2.1
Illnesses of father: None of the above (group 1)	0.8	1.0	3.9	0.8	-1.1	-0.0	-0.1	2.0	0.0	1.0
Miserableness	0.8	1.4	2.9	-0.8	-1.7	1.5	-0.7	1.4	0.3	1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	4.3	0.3	-2.1	-0.4	1.0	0.9	-0.4	-0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	0.2	0.7	-1.3	0.8	-1.4	-0.9	-1.0
Supplements: Calcium	0.8	0.9	2.2	1.5	-1.2	0.0	0.3	1.4	-0.6	-0.5
Schizophrenia vs Biploar Disorder	0.7	0.9	3.4	-0.1	-0.1	1.4	-0.7	0.2	0.8	1.8
Prostate Cancer	0.7	1.0	1.9	-0.7	-0.9	1.0	0.1	1.3	-1.1	1.4
Neuroticism	0.7	1.7	4.6	0.3	-2.2	1.7	-0.6	2.0	-0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.0	-1.2	1.4	-1.3	-0.5	0.7	1.0	0.1
Medication: Co-codamol	0.7	0.8	2.1	0.7	1.1	-0.9	0.6	-0.1	1.4	-0.6
Medication: Metformin	0.7	1.0	2.1	0.3	1.4	-1.0	-0.2	-1.2	0.9	-1.0
Current tobacco smoking	0.7	1.1	2.4	-0.9	0.4	1.0	1.5	0.3	1.0	-1.5
Age when periods started (menarche)	0.7	1.7	4.1	2.0	-2.0	-1.4	-0.3	-0.8	-0.9	-0.5
Serious illness, injury or assault to yourself	0.7	0.8	2.0	0.6	0.9	-1.4	-0.1	-0.8	-0.9	-1.0
Multivitamins +/- minerals	0.7	0.9	5.6	0.3	0.1	-0.3	2.4	-0.3	-0.4	0.2
Supplements: Glucosamine	0.7	0.9	2.6	0.6	1.4	0.3	1.2	-1.6	0.3	-0.3
Mouth/teeth dental problems	0.7	1.0	4.2	0.6	1.1	1.1	2.1	0.1	-0.4	-0.2
Worrier / anxious feelings	0.7	1.3	4.6	-0.1	-2.2	-0.3	1.2	0.9	-1.4	0.1
Noisy workplace	0.7	0.9	3.4	-0.2	0.4	-0.3	0.4	1.1	1.1	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.8	0.2	1.0	-0.3	0.1	0.1	-1.7	-1.4
Breastfed as a baby	0.7	0.9	3.5	0.4	0.3	1.9	-0.7	-1.4	0.2	0.0
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.8	-1.3	-0.4	0.2	1.0	1.0	0.6	1.4
Shortness of breath walking on level ground	0.7	0.8	2.4	0.0	-1.0	1.6	-0.8	0.2	1.2	0.6
Alcohol intake frequency.	0.7	1.5	4.7	-0.0	1.6	-1.4	0.8	0.5	-0.8	-2.2
Age at last live birth	0.7	1.0	1.9	1.4	-1.0	-1.1	-0.1	0.4	-1.3	-1.1
Medication: Aspirin	0.7	1.0	2.6	-1.1	0.9	0.3	0.6	-1.1	1.6	-0.6
Illnesses of siblings: Diabetes	0.7	0.9	3.2	0.8	0.3	0.6	0.7	-1.2	1.8	0.4
Medication: Aspirin	0.7	1.0	2.6	-1.0	0.8	0.5	0.7	-1.1	1.6	-0.7
Arm fat mass (left)	0.7	2.8	6.9	0.6	2.6	0.6	-0.7	-2.6	2.1	-0.6
Average weekly champagne plus white wine intake	0.7	0.9	3.2	0.4	-0.7	-0.2	-1.5	-0.4	1.8	0.7
Wears glasses or contact lenses	0.7	0.8	1.6	-0.5	-0.8	1.1	0.2	0.9	-1.3	1.0
Ever taken oral contraceptive pill	0.7	0.8	2.4	-0.1	0.4	1.2	-1.5	-0.6	0.7	0.7
Illnesses of father: High blood pressure	0.7	0.9	2.8	1.2	-0.4	-1.7	0.1	-1.1	-0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.0	-0.6	-0.0	1.7	-0.1	1.7	0.3	-0.6
Bipolar Disorder or Schizophrenia	0.6	1.5	4.0	-0.8	-2.0	-0.8	0.3	-0.4	-1.9	-1.0
Neuroticism (Nagel 2018)	0.6	1.4	5.5	-0.3	-2.4	1.5	0.2	1.0	-0.8	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.0	-0.0	1.1	0.3	-0.8	-1.1	0.9	1.4
Rheumatoid Arthritis	0.6	0.9	2.0	0.3	-1.4	-1.3	1.4	0.3	-0.5	0.1
Ulcerative Colitis	0.6	0.8	3.0	-1.7	0.0	0.8	0.5	0.5	1.3	0.5
Smoking Status	0.6	1.4	4.6	1.3	0.3	0.1	-1.3	-1.1	2.1	-0.8
Average weekly spirits intake	0.6	0.8	1.6	0.6	0.8	0.3	1.3	1.0	-0.8	-1.1
Fed-up feelings	0.6	1.1	4.6	0.2	-0.9	2.1	1.0	0.8	0.8	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.2	-1.5	0.5	-1.1	-1.4	-0.6	-1.4	-1.0
Qualifications: CSEs or equivalent	0.6	0.8	3.2	1.8	0.1	-0.9	0.1	0.2	0.8	-0.8
Had other major operations	0.6	0.7	1.3	0.7	0.9	-1.2	0.7	-0.9	1.0	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.8	0.5	2.2	0.5	0.3	-0.8	0.9	-0.7
Arm fat mass (right)	0.6	2.6	7.0	0.5	2.6	0.6	-0.6	-2.5	2.0	-0.7
Pulse wave reflection index	0.6	0.8	1.6	-0.8	1.3	1.1	0.7	0.3	-0.2	-1.1
Blood clot in the leg (DVT)	0.6	0.7	1.9	-0.2	0.3	1.4	-0.1	1.3	0.8	-0.9
Glaucoma (self-reported)	0.6	0.7	3.7	0.3	0.4	0.1	-0.3	-0.5	-0.8	-1.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.3	-1.8	1.2	-0.2	1.5	0.4	-0.5	0.6
Medication: Amlodipine	0.6	0.8	1.3	1.1	0.9	-0.3	-0.9	-0.8	0.9	-1.1
Birth weight	0.6	1.3	3.5	1.8	-1.5	1.9	-0.2	0.6	-0.1	0.1
Comparative body size at age 10	0.6	1.7	5.3	-0.4	0.7	1.2	-1.6	-1.3	2.3	0.5
Number of children fathered	0.6	0.7	2.8	-0.8	0.3	0.3	-0.0	0.0	1.0	1.7
Qualifications: College or University degree	0.6	2.0	5.0	0.4	2.0	-0.7	-2.2	-1.7	1.1	-0.3
Medication: Omeprazole	0.6	0.7	2.3	-0.1	-0.4	0.8	1.5	1.2	0.6	0.5
Friendships satisfaction	0.6	0.7	2.6	0.2	0.1	-0.2	-0.9	-0.5	1.1	1.6
Commuting to job workplace: Walk	0.6	0.7	2.9	0.9	1.7	-0.0	0.3	-0.1	0.9	-0.5
Smoking status: Current	0.6	0.9	3.5	-0.5	0.4	0.3	1.3	0.2	0.9	-1.9
Average weekly beer plus cider intake	0.6	0.8	2.6	-0.2	-1.6	0.9	0.3	1.3	-0.6	0.3
Irritability	0.6	1.1	3.7	0.8	0.5	0.2	-1.0	-0.7	1.2	-1.9
Ever depressed for a whole week	0.6	0.8	3.0	0.9	1.1	0.1	0.1	0.1	1.7	0.6
Leg fat mass (left)	0.6	2.4	6.6	0.6	2.3	0.8	-0.5	-2.6	1.7	-0.6
Depression (Nagel 2018)	0.5	0.8	1.2	0.6	0.6	-1.0	-1.1	-0.6	1.1	-1.0
HDL Cholesterol	0.5	0.8	1.9	0.8	-1.0	0.3	-0.7	1.4	-0.8	-0.8
Supplements: Zinc	0.5	0.5	1.6	0.8	-0.2	1.2	-0.2	-0.5	0.6	0.8
Medication: Levothyroxine sodium	0.5	0.9	2.1	-1.4	0.3	-0.0	1.4	0.9	0.2	1.1
Past tobacco smoking	0.5	0.9	3.2	-0.8	0.3	0.4	1.8	0.9	-1.1	-0.6
Hearing difficulty/problems with background noise	0.5	0.8	2.3	-0.8	1.0	-0.7	-1.5	-0.1	1.2	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	2.0	0.1	0.2	1.4	-0.2	0.6	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.9	-1.4	0.4	-0.5	-1.3	-0.9	-1.4	-1.0
Medication: Ramipril	0.5	0.6	1.4	-0.7	0.8	0.4	-0.9	-1.2	0.8	0.4
Alcohol intake versus 10 years previously	0.5	0.7	1.3	-1.1	0.6	-1.1	-0.2	-0.8	-0.5	-1.1
Mouth/teeth dental problems: Dentures	0.5	0.8	2.0	-1.4	-1.2	0.8	-0.0	0.8	-0.1	0.8
Medication: Lansoprazole	0.5	0.6	2.0	-0.6	0.8	-0.0	1.4	-0.2	1.0	0.1
Lung cancer (father)	0.5	0.6	2.1	0.3	-1.0	-0.9	-1.4	-0.2	-0.4	-0.5
Birth weight of first child	0.5	0.8	3.4	1.8	-0.0	-0.2	-1.2	0.5	-0.0	-0.8
Peak expiratory flow (PEF)	0.5	1.2	4.2	-0.4	0.7	-1.8	-2.1	-0.4	0.3	-0.6
Number of full brothers	0.5	0.6	1.6	-0.3	0.1	1.3	0.3	1.2	1.0	0.3
Health satisfaction	0.5	0.6	3.1	0.2	-0.3	-0.1	0.7	1.8	-0.4	0.5
Leg fat mass (right)	0.5	1.9	4.7	0.5	2.0	1.0	-0.6	-2.2	1.6	-0.5
Overall health rating	0.5	1.0	3.8	0.8	-0.2	0.3	1.0	1.9	1.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.5	-0.1	-0.9	-0.9	0.3	-0.0	-1.6	0.2
Average weekly red wine intake	0.5	0.7	3.7	0.0	-0.2	-0.2	-0.9	-1.9	-0.4	-0.7
Mood swings	0.5	0.9	1.8	0.5	-1.1	1.3	-1.1	1.1	0.1	0.8
Osteoporosis (self-reported)	0.5	0.6	1.5	-0.3	-0.5	0.8	1.2	-0.3	-1.0	-0.5
Depressed Affect (Nagel 2018)	0.4	0.8	3.0	-0.3	-1.2	1.7	0.5	0.9	-0.2	-0.4
Schizophrenia (2018)	0.4	0.9	3.0	-0.4	-1.7	0.5	-0.8	-0.6	-1.4	0.0
Reaction Time	0.4	0.8	2.6	-1.6	-0.7	0.4	0.7	1.1	0.5	0.8
Crohns Disease (2012)	0.4	0.7	1.5	-0.9	0.6	-0.7	-1.2	0.5	-0.6	-1.0
Heel T-Score	0.4	2.8	10.2	-2.2	-0.9	0.1	-1.7	0.8	-3.2	-0.3
Hair Pigment	0.4	11.8	33.5	1.3	-5.8	2.0	3.4	4.1	-2.5	3.0
Relative age of first facial hair	0.4	0.7	4.1	0.5	-0.8	0.1	2.0	-0.3	-0.3	-0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.9	-0.4	-0.8	0.0	-0.4	-1.4	0.7	0.1
Ever had hysterectomy (womb removed)	0.4	0.5	2.3	-0.3	1.5	-0.3	-0.4	0.4	0.4	-0.6
Vitamin and mineral supplements	0.4	0.6	3.2	0.5	-0.3	0.4	-1.8	0.0	0.4	0.5
Maternal smoking around birth	0.4	0.6	1.9	-0.6	1.4	-0.8	-0.4	-0.7	0.2	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.7	0.5	0.6	-0.7	-1.2	0.0	0.6	-1.3
Father’s age at death	0.4	0.6	2.2	0.4	-0.1	0.8	0.2	1.5	-0.6	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.7	-0.6	0.6	-1.9	-1.5	-1.4	0.1	0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.2	0.9	-0.8	1.1	-1.1	-0.9	0.4	0.9
Asthma	0.4	0.8	3.0	-0.9	-0.7	0.6	-0.5	-0.3	0.9	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.1	0.6	0.8	0.0	-0.0	-0.0	1.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.4	-0.8	0.9	-1.9	-1.1	-1.5	0.8	0.6
Medication: Paracetamol	0.4	0.6	1.6	-0.8	0.3	-1.2	-0.7	0.7	1.0	0.2
Gout (self-reported)	0.4	0.5	2.1	0.4	-1.5	0.1	-0.2	1.1	0.1	0.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-0.1	-0.4	-0.1	-1.0	-0.6	-1.0	-1.1
Medication: Ibuprofen	0.4	0.5	1.7	0.2	1.0	0.3	0.6	-0.4	1.3	-0.4
Whole body fat mass	0.4	1.7	4.6	0.2	2.1	0.7	-0.1	-2.1	1.5	-0.4
Family relationship satisfaction	0.4	0.5	1.5	0.1	-0.7	-1.2	-1.0	0.1	0.3	0.6
Supplements: Vitamin C	0.4	0.5	1.0	-0.3	-0.2	1.0	-0.0	-0.8	-0.9	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.2	0.2	0.4	-1.5	1.1	0.4	-0.2	0.0
Qualifications: nursing, teaching	0.4	0.6	2.4	1.0	-0.0	0.9	0.1	-1.5	0.2	0.4
Mineral and other dietary supplements	0.4	0.5	1.7	1.3	1.0	0.6	-0.4	-0.1	0.7	0.0
Asthma (self-reported)	0.4	0.7	2.5	-0.9	-0.4	0.3	-0.6	-0.4	1.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.1	-0.5	-1.8	-1.2	-1.1	-0.3	-0.0	0.7
Guilty feelings	0.4	0.7	2.3	1.5	-0.5	0.3	-0.7	-0.1	0.2	-1.2
Mother’s age at death	0.4	0.5	1.8	0.8	-0.2	-0.4	0.3	0.1	-0.8	-1.3
Commuting to job workplace: Public transport	0.4	0.4	1.3	1.0	0.5	-0.3	0.1	-1.1	0.6	-0.4
Unable to work because of sickness or disability	0.4	0.5	1.3	1.0	0.8	-0.4	0.3	0.5	1.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.7	-0.8	0.4	0.2	1.7	0.3	0.3	0.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	-0.3	0.4	-0.1	-1.0	0.6	0.1	1.1
Irritable Bowel Disease (IBD)	0.3	0.7	3.8	-1.9	0.5	-0.3	-0.2	-0.5	0.7	0.4
Schizophrenia (2014)	0.3	0.7	1.7	-1.3	-1.3	0.5	-0.3	-0.4	-1.0	0.5
Hypothyroidism (self reported)	0.3	0.7	2.3	-1.0	0.7	0.5	1.5	0.8	-0.5	-0.1
Respiratory disease	0.3	0.7	2.3	-1.5	-0.6	-0.5	-0.2	0.1	-0.0	1.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	0.3	-0.0	-0.9	-1.1	0.4	0.6	-0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.5	-0.1	0.1	0.3	1.2	0.1	-0.2	-0.8
Pack years adult smoking proportion	0.3	0.4	1.7	-0.7	0.0	1.3	0.6	0.2	0.5	-0.4
Taking other prescription medications	0.3	0.4	1.5	0.1	0.8	-0.5	-0.7	0.4	1.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.2	-0.0	-0.3	-0.2	-0.2	0.3	1.1	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.5	0.6	-0.0	1.2	-0.1	0.1	-0.7	-0.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.0	0.6	-0.2	-1.0	-0.7	-0.3	-0.0	1.4
Sitting height	0.3	2.2	5.0	1.0	1.7	-1.8	-2.2	-1.2	-0.9	-1.0
Trunk fat mass	0.3	1.3	4.4	0.1	1.8	0.3	-0.3	-2.1	1.0	-0.4
Forced vital capacity (FVC)	0.3	1.1	4.0	-0.5	0.6	-2.0	-1.2	-1.1	-0.3	0.7
Allergy	0.3	0.8	3.4	0.4	0.5	-0.5	1.1	-0.3	-0.1	-1.9
Arm fat percentage (right)	0.3	1.2	2.9	-0.4	1.5	1.1	0.9	-1.7	1.3	-0.0
Number of live births	0.3	0.5	1.4	1.2	0.9	0.1	0.6	0.1	-0.4	-0.8
Prospective memory result	0.3	0.4	2.0	-0.1	-1.4	-0.7	0.6	0.1	-0.3	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.6	0.0	-0.5	-1.3	-1.1	-0.5	-0.6	-0.5
Headache pain in last month	0.3	0.6	1.4	-0.5	-1.2	-0.2	0.8	1.1	-0.8	0.1
Forced vital capacity (FVC), Best measure	0.3	1.0	2.5	-1.1	0.9	-1.6	-0.9	-0.9	-0.1	0.7
Age at first live birth	0.3	0.6	2.2	-0.7	-0.9	-0.5	-0.6	-0.1	-1.5	0.0
Mean time to correctly identify matches	0.3	0.7	2.0	-1.4	-1.0	0.4	0.4	0.9	0.4	0.6
Illnesses of father: Heart disease	0.3	0.4	1.3	-0.3	1.2	0.6	-0.7	-0.0	0.8	-0.4
Arm fat percentage (left)	0.3	1.4	3.7	-0.3	1.3	1.2	0.0	-1.9	1.6	-0.0
Ever had bowel cancer screening	0.3	0.3	0.7	0.5	-0.3	-0.1	-0.8	-0.2	0.8	0.7
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.6	0.2	0.5	0.4	-0.9	0.8	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.5	1.1	-0.7	-0.8	-0.4	0.4	0.4	-1.0	-0.7
Medication: Paracetamol	0.3	0.5	1.2	-0.0	0.0	-1.1	-0.6	0.8	1.0	-0.1
Ever smoked	0.3	0.4	1.1	0.4	0.2	-1.1	-0.8	-0.7	0.9	0.1
Leg fat percentage (left)	0.3	1.1	2.7	-0.0	1.4	1.1	0.5	-1.7	1.1	-0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	-0.5	-0.8	-0.5	-0.2	0.4	-1.1	-0.4
Pack years of smoking	0.3	0.5	1.6	-0.9	0.5	1.3	0.8	-0.3	0.4	-0.3
Crohns Disease (2017)	0.2	0.5	1.6	-1.0	0.6	-0.6	-1.3	0.3	-0.2	-0.6
Major Depression (MDD)	0.2	0.3	1.9	0.0	0.0	0.0	0.0	0.0	1.4	0.0
Breast Cancer	0.2	0.6	2.3	0.8	-0.0	0.3	0.5	-0.2	1.0	1.5
Ovarian Cancer	0.2	0.3	1.6	-0.1	-0.0	-0.3	1.3	-0.4	-0.2	-0.1
Blood Red Count	0.2	2.1	8.6	-0.4	0.9	1.4	1.3	-0.4	-2.9	-1.1
Allergy or Eczema	0.2	0.6	1.1	0.9	0.3	-0.8	-1.0	-0.4	-0.1	1.1
Lung FVC	0.2	0.9	2.1	-1.3	1.2	-0.7	-0.3	-1.5	0.8	0.2
Severe depression (siblings)	0.2	0.3	0.6	0.8	-0.5	0.8	0.4	-0.1	0.4	-0.3
Hand grip strength (right)	0.2	0.6	2.6	-0.7	0.6	0.1	-1.6	-0.7	0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	0.5	0.8	-0.5	-0.4	-0.7	0.4	-0.0
Alcohol usually taken with meals	0.2	0.3	0.9	1.0	0.3	0.0	-0.1	-0.7	0.5	-0.4
Qualifications: None of the above	0.2	0.4	1.3	-0.2	0.4	0.6	1.0	-0.5	1.1	0.1
Standing height	0.2	1.9	3.4	0.3	1.8	-1.8	-1.4	-0.5	-1.6	-1.3
Body fat percentage	0.2	0.9	2.0	-0.6	1.0	1.1	0.9	-1.4	0.8	0.3
Leg fat percentage (right)	0.2	0.9	2.6	-0.2	1.0	1.6	0.3	-1.1	1.2	0.0
Wheeze or whistling in the chest in last year	0.2	0.3	1.4	0.5	0.5	0.2	0.4	-0.1	1.2	-0.1
Pulse rate, automated reading	0.2	0.7	4.0	-0.2	-0.5	-0.1	-0.5	2.0	-0.7	0.3
Comparative height size at age 10	0.2	1.3	3.8	-1.8	0.6	-0.4	-1.2	2.0	-0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.6	-1.2	1.2	-0.4	-0.1	0.2	0.1	0.4
Age started oral contraceptive pill	0.2	0.2	0.6	-0.2	0.2	0.4	-0.8	-0.6	-0.2	-0.1
Height	0.1	2.7	12.0	-0.6	1.3	-1.7	-3.5	1.4	-0.3	0.1
Waist Hip Ratio (WHR)	0.1	0.4	1.9	0.4	0.7	0.4	-0.0	-1.4	0.1	-0.2
Lung FEV1/FVC ratio	0.1	0.4	1.3	0.6	-0.2	-0.3	-0.8	-0.0	1.1	-0.7
Tanning	0.1	0.7	3.4	-1.8	0.1	0.9	0.3	0.4	-0.8	0.3
Hand grip strength (left)	0.1	0.4	1.1	-0.2	-0.5	-0.3	-1.1	-0.0	-1.0	-0.1
Hearing difficulty/problems: Yes	0.1	0.1	0.5	-0.7	0.3	-0.6	0.0	0.2	-0.0	-0.1
Trunk fat percentage	0.1	0.6	1.7	-0.8	0.8	0.6	0.6	-1.3	0.5	0.3
Stomach or abdominal pain in last month	0.1	0.2	0.4	0.6	-0.2	-0.6	-0.4	-0.4	0.0	-0.2
Heart attack	0.1	0.1	0.3	-0.1	-0.1	0.5	0.0	0.5	-0.6	0.0
Medication: Allopurinol	0.1	0.1	0.5	-0.7	-0.1	-0.2	-0.1	0.5	0.5	-0.0
Hearing aid user	0.1	0.1	0.4	0.5	0.1	0.1	-0.1	0.1	-0.7	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	1.5	-0.3	1.2	-0.1	0.6	-0.4	0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.1	0.4	0.5	0.2	0.4	-0.5	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

COMT

Models

Trait associations