Hub : Genes

CECR6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1069	0.0264	7.5e-07	0.062	0.040	0.054	0.057	0.051	1.1e-09	1.0e-06	1.3e-08	5.8e-09	4.3e-08
2	NTR	Blood	0.0778	0.0153	4.6e-12	0.066	0.053	0.062	0.067	0.067	2.2e-20	9.2e-17	2.6e-19	1.4e-20	1.4e-20
3	YFS	Blood	0.4996	0.0274	0.0e+00	0.280	0.497	0.517	0.509	0.493	2.3e-92	9.6e-191	5.9e-202	5.9e-197	1.7e-188
4	TCGA	Colon Adenocarcinoma	0.1530	0.0680	4.6e-03	0.026	0.061	0.053	NA	0.022	1.2e-02	1.9e-04	5.3e-04	NA	1.8e-02
5	TCGA	Lung Adenocarcinoma	0.0478	0.0196	7.4e-05	0.032	0.035	0.029	NA	0.035	1.2e-04	4.9e-05	2.0e-04	NA	5.7e-05
6	TCGA	Lung Squamous Cell Carcinoma	0.0424	0.0257	9.7e-03	0.047	0.010	0.007	NA	0.038	4.2e-06	2.3e-02	4.7e-02	NA	3.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.7	2.4	-0.4	-0.4	-0.4	0.6	1.0	-1.6
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	-0.8	-0.9	-0.7	0.4	0.5	-1.3
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	-1.1	-0.8	-0.7	-0.9	0.1	-1.0
Depression (Nagel 2018)	0.2	0.3	0.8	-0.9	-0.5	-0.1	-0.4	-0.1	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.3	0.9	0.2	0.7	-1.5	0.1	-0.8
Neuroticism (Nagel 2018)	0.2	0.5	2.0	-0.6	0.1	-0.0	0.5	1.4	-0.8
Schizophrenia (2018)	0.2	0.4	0.9	-0.9	-0.9	-0.5	-0.0	-0.2	-0.5
Schizophrenia vs Biploar Disorder	5.7	7.5	8.7	-2.2	-2.9	-2.6	-2.9	-2.9	-2.8
Worry (Nagel 2018)	0.2	0.5	1.2	-1.1	-0.3	-0.4	1.0	0.3	-0.6
Alzheimer’s Disease (in mother)	0.6	0.7	2.8	0.0	-0.1	-0.7	-1.0	-0.3	-1.7
Alzheimer’s Disease (in father)	0.4	0.5	1.1	0.7	0.8	1.1	-0.2	0.3	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.8	2.5	0.4	-0.2	0.0	-1.3	-0.6	-1.6
Crohns Disease (2017)	0.9	2.0	2.9	-1.2	-1.7	-1.6	-1.2	-1.4	-1.2
Irritable Bowel Disease (IBD)	0.3	0.7	1.1	-0.8	-1.0	-0.7	-1.0	-0.1	-1.0
Ulcerative Colitis (UC)	0.2	0.3	0.6	-0.2	-0.1	0.5	-0.6	0.7	-0.8
Major Depression (MDD)	0.4	0.5	1.1	0.6	0.4	1.0	0.5	1.0	0.1
Reaction Time	0.5	0.9	2.4	0.1	0.7	1.1	-0.4	1.5	1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.5	-0.2	-0.7	-0.3	-1.6	-0.6	-1.0
Breast Cancer	0.2	0.6	1.8	1.4	1.1	0.3	-0.4	0.2	0.5
Ovarian Cancer	1.6	2.1	4.2	2.0	2.0	1.0	-0.2	1.7	0.7
Prostate Cancer	0.3	0.4	1.1	0.6	0.8	0.1	1.0	0.4	0.5
Age at First Birth	0.5	0.8	1.7	-0.9	-0.7	-1.0	1.3	-0.2	-0.8
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.0	0.0	0.6	0.4	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	3.2	-0.7	-1.0	-0.3	-1.6	-1.8	-0.2
Coronary Artery Disease (CAD)	1.2	1.4	2.9	1.2	0.9	1.7	0.5	0.6	1.6
Crohns Disease (2012)	4.3	6.9	11.7	-2.9	-3.4	-3.4	-0.8	-2.6	-1.7
Mean Putamen Volume	2.6	3.0	6.3	2.5	2.2	2.1	-0.2	1.5	0.5
Fasting Glucose	0.5	0.6	1.2	-0.8	-0.5	-1.1	0.2	-1.0	0.7
HbA1C	0.7	0.8	1.8	0.6	1.3	1.2	-0.2	1.0	-0.5
HDL Cholesterol	1.3	2.2	4.9	-1.4	-1.6	-1.8	0.1	-2.2	-0.6
LDL Cholesterol	0.1	0.2	0.7	0.2	-0.2	0.4	0.1	0.5	-0.8
Lupus	0.3	0.4	0.8	-0.9	-0.7	-0.8	-0.7	0.0	0.4
Neuroticism (2016)	0.3	0.4	1.2	-0.6	0.4	0.5	0.6	0.6	-1.1
Primary Biliary Cirrhosis	0.6	0.9	3.1	-0.5	-0.7	-0.9	0.4	-0.7	-1.8
Rheumatoid Arthritis	0.8	1.1	3.1	0.7	0.5	-0.3	1.8	0.4	1.4
Schizophrenia (2014)	0.8	1.7	2.6	-1.1	-1.5	-0.8	-1.5	-1.0	-1.6
Triglycerides	0.9	1.4	2.9	1.2	1.3	1.6	0.2	1.7	0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	0.5	0.2	0.4	-1.0	-1.2	-0.7
Ulcerative Colitis	0.0	0.1	0.2	0.2	0.1	0.0	-0.2	0.5	-0.2
Blood Eosinophil Count	1.6	12.1	24.0	-4.9	-4.2	-3.1	1.3	-0.9	-4.3
Blood Platelet Count	0.1	1.3	3.0	0.8	0.8	1.5	-0.7	1.0	-1.7
Blood Red Count	0.4	3.7	9.1	-1.2	-1.6	-0.7	-2.2	-1.9	-3.0
Blood White Count	3.8	28.4	58.1	-7.6	-6.3	-4.9	0.8	-1.9	-6.6
Heel T-Score	0.0	0.2	0.5	-0.1	0.1	0.6	0.7	0.4	-0.2
BMI	0.1	0.5	1.6	-0.0	-0.1	0.3	-0.7	-0.7	-1.3
Height	0.1	1.9	3.1	-1.2	-0.8	0.7	-1.7	-1.7	-1.8
Waist Hip Ratio (WHR)	0.6	2.6	6.5	-1.6	-2.6	-1.8	1.5	0.2	-0.9
Systolic Blood Pressure	0.1	0.3	0.8	0.1	0.2	-0.6	0.6	0.0	0.9
Smoking Status	1.5	3.5	6.4	-2.2	-2.5	-2.5	1.5	-1.2	-0.5
Allergy or Eczema	0.4	0.9	4.3	-0.1	0.2	0.9	-0.5	0.5	-2.1
Cardiovascular Disease	0.1	0.5	2.5	-0.4	0.0	-0.2	-0.2	0.4	-1.6
Hypothyroidism (self reported)	0.1	0.3	0.8	-0.3	-0.7	-0.9	-0.2	-0.3	-0.4
Respiratory disease	0.7	1.6	2.5	-1.2	-1.4	-0.9	-0.8	-1.5	-1.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.3	0.6	0.2	-0.2	-0.7	0.1	-1.1
Lung FEV1/FVC ratio	0.0	0.2	0.8	0.3	0.1	0.2	-0.0	-0.9	0.0
Lung FVC	0.1	0.5	1.0	1.0	0.8	0.7	-0.5	0.2	-0.7
Neuroticism	0.5	1.1	2.4	-1.3	-0.5	-0.9	1.2	0.2	-1.6
Chronotype (morning person)	0.3	0.7	2.6	-0.0	0.4	-0.4	-1.0	-0.3	-1.6
Hair Pigment	0.0	0.3	0.5	0.5	0.2	0.7	-0.7	0.1	0.6
Tanning	0.1	0.7	2.0	-0.2	0.4	0.3	1.3	0.4	1.4
Hand grip strength (left)	0.2	0.5	1.2	-0.4	-0.3	-0.0	-0.5	-1.1	-1.1
Number of treatments/medications taken	0.2	0.4	1.0	-1.0	-0.6	0.1	0.3	0.2	-1.0
Average weekly spirits intake	0.8	1.0	2.0	1.2	1.4	0.8	0.6	0.8	0.8
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.5	0.1	0.3	-0.3	0.9	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.6	0.2	0.7	0.4	-0.1	0.8	0.2
Hearing difficulty/problems: Yes	0.2	0.4	0.8	-0.9	-0.0	0.5	-0.6	-0.7	-0.4
Relative age of first facial hair	1.0	2.1	4.2	1.0	1.4	1.4	1.4	2.0	1.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	2.7	-1.6	-1.5	-0.8	-1.4	-1.2	-1.5
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.0	-2.0	-1.8	-1.6	-0.2	-1.9	-1.3
Ever had hysterectomy (womb removed)	0.5	0.5	1.7	-1.3	-0.7	-0.8	-0.2	-0.6	-0.1
Systolic blood pressure, automated reading	0.1	0.3	0.6	0.1	0.1	-0.8	0.7	-0.3	-0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.7	1.3	0.4	0.5	0.1	0.5	-0.7
Angina	0.8	1.0	2.7	1.0	0.8	0.5	-1.0	1.6	-0.7
Medication for hormone replacement therapy	0.4	0.4	1.5	-1.2	-0.9	-0.2	-0.4	-0.2	0.1
Vitamin and mineral supplements	0.9	1.2	5.5	0.5	-0.0	0.6	-1.0	0.5	-2.3
Supplements: Zinc	0.7	0.8	1.2	-1.0	-1.1	-0.8	-1.1	-0.4	-0.8
Medication: Co-codamol	0.9	1.0	2.3	0.7	0.7	0.5	1.4	1.5	0.8
Medication: Metformin	0.9	1.3	5.7	-0.5	-0.9	-0.9	-0.3	0.2	-2.4
Diabetes (father)	0.2	0.2	0.5	-0.6	-0.2	-0.4	-0.7	0.4	0.3
Diabetes (mother)	0.9	1.1	2.8	1.7	1.1	1.2	0.8	0.0	-0.6
Severe depression (siblings)	0.5	0.5	2.5	0.1	0.3	0.6	0.3	0.4	-1.6
Pack years adult smoking proportion	0.4	0.6	1.0	0.8	0.5	1.0	-0.4	0.8	-0.9
Impedance of leg (right)	0.1	0.4	1.3	-0.5	-0.7	-1.2	0.1	0.1	-0.4
Leg fat-free mass (left)	0.2	0.9	1.8	-0.7	-0.7	0.7	-0.8	-1.3	-1.3
Trunk fat percentage	0.1	0.3	1.0	-0.4	-0.4	-0.6	-0.1	-0.0	-1.0
Hand grip strength (right)	0.3	0.8	1.8	0.5	0.5	1.3	-0.9	-0.1	-1.2
Townsend deprivation index at recruitment	0.0	0.1	0.2	-0.1	0.2	0.0	0.1	0.5	-0.1
Current tobacco smoking	0.1	0.1	0.3	-0.2	-0.6	-0.4	0.3	0.2	0.1
Average weekly fortified wine intake	0.2	0.3	1.1	-0.3	-0.5	-0.5	0.0	-1.0	0.0
Maternal smoking around birth	0.5	0.7	1.7	0.8	0.7	1.0	-1.3	0.1	0.4
Fed-up feelings	0.2	0.4	1.5	-1.2	-0.6	-0.2	-0.9	0.0	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.4	0.5	1.0	1.5	-0.3	0.8	-0.2
Relative age voice broke	0.6	0.9	1.7	-1.1	-1.2	-0.6	1.3	0.6	-0.4
Taking other prescription medications	1.0	1.5	2.7	-1.3	-1.4	-0.1	-1.2	-1.1	-1.7
Age when periods started (menarche)	0.3	0.8	1.7	-1.2	-1.2	-1.3	0.2	-0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	-1.1	-1.3	-0.2	1.0	-0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.5	0.5	0.6	0.4	0.3	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	0.8	0.8	0.3	0.6	0.8	-0.4
Qualifications: CSEs or equivalent	0.6	0.8	3.0	0.9	0.6	0.7	0.5	0.4	1.7
Serious illness, injury or assault to yourself	1.2	1.5	3.7	-1.9	-1.4	-0.9	0.2	0.1	-1.6
High blood pressure	0.4	1.2	2.3	0.5	1.5	1.5	0.7	1.2	-0.5
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.2	-1.2	-1.2	-1.0	-0.8	-1.2	-1.8
Multivitamins +/- minerals	0.9	1.1	1.7	-1.1	-0.8	-1.3	0.9	-0.8	1.2
Stomach or abdominal pain in last month	0.7	0.9	1.8	-1.1	-1.1	-1.3	0.9	-0.2	-0.2
Supplements: Glucosamine	2.5	3.3	6.2	-1.4	-2.4	-2.4	0.1	-2.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	-0.1	-0.8	-0.8	-0.8	-0.9	0.2
Medication: Atenolol	1.0	1.2	2.6	1.1	1.6	0.1	0.7	1.6	0.7
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.3	-0.3	-0.4
Sitting height	0.1	0.4	1.4	-0.5	-0.0	1.2	0.3	-0.6	-0.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	1.0	1.0	0.4	0.5	0.4	-1.3
High blood pressure (mother)	0.7	0.9	2.4	0.5	1.1	0.8	-1.6	0.4	-0.9
Body mass index (BMI)	0.1	0.6	1.9	0.1	-0.2	0.0	-0.8	-0.9	-1.4
Impedance of leg (left)	0.0	0.1	0.5	0.0	-0.1	-0.7	-0.0	0.5	0.0
Leg predicted mass (left)	0.2	1.0	2.2	-0.8	-0.8	0.6	-0.8	-1.5	-1.3
Trunk fat mass	0.2	0.7	2.5	-0.7	-0.6	-0.4	-0.5	-0.8	-1.6
Waist circumference	0.5	1.8	4.1	-1.1	-1.4	-1.1	-0.3	-1.5	-2.0
Number of incorrect matches in round	0.7	1.1	2.4	-1.4	-1.1	-1.0	-0.3	-1.5	0.1
Past tobacco smoking	0.7	1.3	2.2	1.1	1.1	1.4	-0.4	1.5	1.0
Alcohol usually taken with meals	0.7	1.1	2.9	0.3	0.4	0.8	-1.6	-0.2	-1.7
Nervous feelings	0.3	0.6	1.7	-0.7	-0.0	0.2	1.2	1.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	-0.8	-0.1	0.7	-0.6	-0.4	0.2
Hearing difficulty/problems with background noise	4.8	7.6	15.1	-2.7	-2.3	-1.8	-3.0	-2.5	-3.9
Hair/balding pattern: Pattern 2	1.1	1.4	4.6	-1.4	-0.8	-0.2	1.0	0.4	-2.1
Had menopause	0.9	1.1	3.3	-0.4	-0.8	-1.4	0.6	-1.8	0.5
Had other major operations	2.4	3.0	5.0	-1.8	-2.1	-1.9	-0.9	-2.2	-0.8
Forced vital capacity (FVC)	0.2	0.6	1.5	0.7	0.4	0.9	-1.2	-0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.4	0.4	1.0	0.7	0.8	-0.2
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	6.5	0.5	1.1	-0.0	2.5	1.7	1.2
Qualifications: None of the above	0.1	0.2	0.8	0.0	0.1	-0.2	0.9	0.3	0.1
Financial difficulties in last 2 years	0.3	0.5	2.0	0.3	0.5	0.3	-1.4	0.3	0.5
Mouth/teeth dental problems	0.2	0.3	0.8	0.2	-0.4	-0.2	-0.3	-0.9	0.9
Heart attack	0.3	0.4	1.0	-0.0	0.2	0.3	0.9	0.7	1.0
Allergy	1.5	3.4	6.9	1.9	2.0	1.1	1.0	1.9	2.6
Pain all over the body in last month	0.5	0.5	1.7	0.4	-0.3	0.4	-0.8	-0.5	-1.3
Diabetes (self-reported)	1.0	1.5	6.6	-0.9	-0.8	-1.1	0.1	-0.1	-2.6
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.8	-1.2	-1.6	-1.9	0.1	-1.7	-1.4
Medication: Ramipril	1.7	2.2	7.9	-1.7	-0.9	-0.8	-0.9	-0.5	-2.8
Medication: Simvastatin	0.3	0.4	1.9	0.4	0.2	-0.2	-0.6	-0.0	-1.4
Fluid intelligence score	0.5	0.9	2.8	-0.2	-0.8	0.0	-1.7	-0.9	-1.2
Illnesses of siblings	0.4	0.5	2.2	0.3	-0.1	-0.8	0.4	0.5	1.5
Neuroticism score	0.5	1.0	2.0	-1.4	-0.5	-0.8	1.1	0.1	-1.3
Weight	0.3	1.5	4.4	-0.7	-0.8	0.1	-0.8	-1.6	-2.1
Impedance of arm (right)	0.3	1.4	3.7	-0.6	0.1	-1.1	1.7	1.9	0.7
Arm fat percentage (right)	0.1	0.5	1.9	-0.6	-0.5	-0.6	-0.5	-0.2	-1.4
Trunk fat-free mass	0.4	2.4	5.7	-0.7	-0.9	0.8	-1.6	-2.4	-2.1
Hip circumference	0.4	1.8	3.7	-1.0	-1.0	-0.6	-1.3	-1.7	-1.9
Time employed in main current job	0.2	0.3	0.7	-0.6	-0.2	-0.2	-0.5	-0.5	0.8
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.2	-0.1	0.4	-0.6	-0.7	0.7
Father’s age at death	1.3	1.8	3.4	-1.4	-1.3	-1.8	-0.2	-1.1	-1.6
Worrier / anxious feelings	0.4	0.8	1.9	0.4	1.0	1.1	0.7	1.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.1	0.5	0.0	0.1	0.5	-0.8
Falls in the last year	0.5	0.7	2.3	-0.7	-0.5	-0.9	-0.3	-1.5	-0.3
Hair/balding pattern: Pattern 3	0.6	0.9	2.6	0.7	0.7	1.0	-1.6	1.0	-0.2
Number of live births	1.3	1.9	3.4	-1.5	-1.9	-1.4	-0.5	-1.2	-1.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.0	1.3	1.2	1.7	-1.0	0.0	0.1
Pulse rate	0.3	0.5	0.9	0.5	-0.5	-1.0	-0.9	-0.8	-0.4
Happiness	0.2	0.3	0.6	-0.2	0.1	-0.7	0.8	0.5	-0.6
Noisy workplace	0.9	1.1	3.6	-0.9	-1.0	0.1	-0.6	-0.8	-1.9
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.1	-1.0	-1.0	0.6	-1.4	-0.1	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.1	0.4	0.5	0.8	-1.2	0.5	-1.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	1.1	1.1	-0.4	0.9	0.3	0.7
Asthma	0.5	0.9	1.6	-0.9	-1.2	-0.7	-0.1	-1.0	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.1	1.5	1.4	1.0	0.4	1.0	0.6
Medication: Cholesterol lowering	0.5	0.7	3.2	-0.2	-0.2	-0.6	0.6	0.5	-1.8
Depression (self-reported)	1.6	1.9	5.0	1.3	1.5	2.2	0.3	1.3	0.5
Medication: Lansoprazole	1.4	1.6	4.0	0.9	0.8	1.0	2.0	1.4	0.9
Prospective memory result	0.2	0.3	1.1	-0.5	-0.6	-1.0	0.3	-0.1	0.0
Lung cancer (father)	0.4	0.5	1.2	0.6	0.9	0.6	-0.4	1.1	0.2
Illnesses of mother	0.6	0.8	1.9	0.3	0.3	0.6	0.9	1.4	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.1	1.0	0.8	1.1	-0.7	0.2	0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.3	0.5	-0.5	-0.5	0.5	0.2
Impedance of arm (left)	0.2	1.1	3.4	0.1	0.6	-0.5	1.2	1.8	1.2
Arm fat mass (right)	0.2	0.8	2.5	-0.6	-0.6	-0.3	-0.8	-1.0	-1.6
Trunk predicted mass	0.4	2.5	6.0	-0.8	-0.9	0.8	-1.6	-2.5	-2.1
Standing height	0.3	3.0	5.3	-2.2	-1.7	-0.3	-0.5	-2.3	-2.2
Length of working week for main job	1.0	1.1	2.6	1.6	1.4	1.2	0.0	-0.1	0.9
Exposure to tobacco smoke at home	0.2	0.3	0.7	0.1	-0.8	-0.8	-0.1	-0.6	-0.0
Breastfed as a baby	2.5	3.1	5.9	-1.6	-1.7	-1.6	-0.6	-2.1	-2.4
Tense / ‘highly strung’	0.1	0.2	0.3	-0.0	0.6	0.6	0.5	0.0	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.9	0.4	0.6	1.1	1.2	1.7	0.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.7	0.3	0.7	-0.3	-0.2	0.2
Birth weight of first child	0.7	1.3	1.8	-1.0	-1.3	-1.3	-1.1	-1.2	-0.9
Peak expiratory flow (PEF)	0.8	1.9	4.6	1.7	1.8	2.1	-0.5	0.2	0.5
Pulse wave reflection index	1.5	1.8	3.5	1.4	1.9	1.3	-0.0	1.6	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.8	-0.3	-0.1	0.3	1.7	0.8	-0.1
Loud music exposure frequency	0.3	0.3	0.7	0.7	0.1	-0.4	0.9	0.7	0.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	0.8	0.4	1.0	-0.4	-0.1	1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	4.0	-0.7	0.1	0.9	0.2	0.6	-2.0
Blood clot in the leg (DVT)	0.8	1.1	2.0	-1.4	-1.0	-0.7	-0.5	-0.8	-1.4
Medication: Paracetamol	0.2	0.4	1.7	-0.1	0.3	-0.2	-0.4	0.4	-1.3
Headache pain in last month	0.4	0.7	1.2	0.7	0.6	1.1	-1.1	0.6	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.4	0.9	0.5	0.7	0.1	0.0	1.5
Glaucoma (self-reported)	1.3	1.5	3.6	0.9	1.1	0.2	1.9	1.1	1.5
Gout (self-reported)	0.3	0.4	1.4	0.0	-0.7	0.2	-1.2	-0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	0.0	-0.7	-0.8	-0.5	-0.7	-0.2
Medication: Amlodipine	0.3	0.4	0.8	0.7	0.9	0.2	0.7	0.3	-0.4
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.2	-0.3	-0.1	-0.1	0.4	-0.0	0.3
Birth weight	0.1	0.2	0.8	-0.2	0.2	0.2	0.3	0.1	-0.9
Chronic bronchitis/emphysema (mother)	1.8	2.1	4.2	1.8	2.0	1.8	-0.2	1.3	0.5
High blood pressure (siblings)	0.6	0.8	1.6	0.9	1.0	0.6	-1.3	-0.1	-1.1
Forced vital capacity (FVC), Best measure	0.1	0.2	0.6	0.4	0.3	0.6	-0.7	-0.3	-0.5
Body fat percentage	0.2	0.7	2.2	-0.7	-0.7	-0.8	-0.6	-0.5	-1.5
Leg fat percentage (right)	0.6	2.3	5.8	-1.0	-1.5	-1.2	-1.0	-1.4	-2.4
Arm fat-free mass (right)	0.5	2.5	6.5	-0.8	-1.1	0.5	-1.3	-2.6	-2.1
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.7	-0.2	-0.7	0.2	-0.4	0.8
Comparative body size at age 10	0.1	0.4	1.3	1.2	0.2	-0.5	-0.4	0.6	-0.4
Number of full brothers	1.1	1.4	3.2	1.1	0.9	1.8	-0.6	1.7	-0.1
Worry too long after embarrassment	1.4	2.3	4.8	0.9	1.9	1.3	1.0	2.2	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.6	0.2	0.4	0.8	-0.3	0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.7	0.2	0.7	-0.3	0.1	-0.4
Number of children fathered	0.4	0.5	1.5	-0.9	-0.6	0.1	0.4	-0.2	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.0	1.1	1.7	1.2	0.0	-0.1	2.0
Age at first live birth	0.3	0.5	1.0	-0.5	-0.6	-0.9	0.6	0.1	-1.0
Pulse wave peak to peak time	0.2	0.3	0.6	0.1	-0.7	0.3	0.6	-0.7	-0.4
Health satisfaction	1.4	1.8	2.4	-1.4	-1.6	-1.6	1.2	-1.4	-0.7
Shortness of breath walking on level ground	0.3	0.4	1.0	-0.2	-0.3	-0.3	-1.0	-0.6	-0.8
Qualifications: College or University degree	0.7	2.2	6.4	-1.5	-1.4	-1.1	-0.1	-1.2	-2.5
Eye problems/disorders: None of the above	0.9	1.1	4.1	0.0	0.1	1.3	-2.0	-0.4	-0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	-0.8	-0.7	-1.1	0.7	-0.3	-0.8
Emphysema/chronic bronchitis	0.3	0.3	1.1	-0.2	-0.1	0.5	-1.0	0.1	-0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	-1.0	-1.4	-0.9	-0.2	-1.3	-0.7
Neck or shoulder pain in last month	0.3	0.5	1.6	0.2	0.0	-0.2	1.3	0.5	-0.9
Medication: Blood pressure	0.2	0.4	1.5	-0.5	0.2	-0.3	-0.6	-0.1	-1.2
Angina (self-reported)	0.6	0.8	1.7	0.8	0.5	0.3	-1.0	1.3	-1.0
Migraine (self-reported)	0.3	0.4	0.7	-0.8	-0.4	-0.8	-0.1	0.1	-0.8
Medication: Ibuprofen	0.6	0.7	1.4	1.2	1.0	0.8	0.4	0.8	0.5
Medication: Allopurinol	0.2	0.3	0.7	-0.2	-0.8	0.1	-0.5	0.0	-0.8
Medication: Omeprazole	0.2	0.2	0.4	-0.4	-0.1	-0.5	0.5	0.6	-0.1
Medication: Seretide 50 evohaler	0.3	0.3	1.3	-0.1	-0.2	-1.2	0.5	-0.4	0.5
Mean time to correctly identify matches	0.3	0.5	1.1	-0.2	0.6	1.1	-0.0	0.8	0.9
Heart disease (mother)	0.2	0.3	0.6	0.8	0.3	0.4	0.8	0.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.9	-0.0	-0.4	-0.6	-0.0	-0.4	-1.4
Whole body fat mass	0.2	1.0	3.0	-0.8	-0.8	-0.4	-0.8	-0.9	-1.7
Leg fat mass (right)	0.7	2.7	6.3	-1.3	-1.6	-0.9	-1.2	-1.7	-2.5
Arm predicted mass (right)	0.4	2.0	5.1	-0.5	-1.0	0.9	-1.3	-2.3	-1.9
Pulse rate, automated reading	0.2	0.7	1.8	1.3	0.3	0.1	-1.3	-0.0	-0.7
Alcohol intake frequency.	0.2	0.5	1.7	0.4	0.5	0.9	-0.4	0.3	1.3
Comparative height size at age 10	1.4	7.7	11.4	-3.3	-3.4	-2.6	-0.0	-3.4	-2.4
Number of full sisters	0.8	1.0	2.6	0.8	0.6	1.4	0.1	1.6	0.4
Suffer from ‘nerves’	0.3	0.4	0.9	-1.0	-0.3	-0.5	0.2	-0.7	-0.9
Overall health rating	0.5	1.1	1.9	1.2	0.7	0.8	1.0	1.4	-1.0
Chest pain or discomfort	2.7	3.9	14.3	-1.5	-1.9	-0.3	-1.3	-1.3	-3.8
Had major operations	0.5	0.6	1.4	0.2	0.9	0.1	1.0	1.2	0.4
Age at last live birth	0.7	1.0	1.7	-1.2	-1.2	-1.3	0.8	-0.1	-0.8
Family relationship satisfaction	0.8	1.0	4.1	-0.6	-0.1	-0.9	2.0	0.8	0.0
Leg pain on walking	0.4	0.5	1.0	-0.7	-0.6	-0.7	-1.0	-0.2	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.0	1.5	1.2	2.0	-0.4	1.7	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.6	0.0	0.3	-0.2	-0.3	0.1	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	-0.5	-0.6	-0.1	1.5	-0.3	1.1
Medication: Aspirin	0.2	0.3	0.5	-0.1	0.4	0.4	0.6	0.6	0.7
Supplements: Vitamin C	0.6	0.7	1.8	-0.1	-0.2	-0.4	-0.8	-1.4	1.2
Knee pain experienced in last month	0.4	0.5	1.8	0.2	0.4	0.6	1.3	1.0	-0.1
Hypertension (Self-reported)	0.2	0.7	1.0	-0.0	1.0	1.0	1.0	1.0	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.4	1.4	1.1	1.1	0.2	1.6	-0.4
Illnesses of father: Heart disease	0.8	1.1	2.0	1.3	1.0	1.3	0.2	1.4	0.6
Illnesses of siblings: Diabetes	0.8	1.0	2.1	-1.2	-0.3	0.0	-1.3	-1.4	-0.8
Smoking status: Previous	1.0	1.5	2.9	-1.1	-1.1	-1.5	0.4	-1.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.5	0.4	0.6	0.3	0.3	0.1
Whole body fat-free mass	0.3	1.8	4.2	-0.6	-0.8	0.9	-1.4	-2.0	-1.8
Leg fat-free mass (right)	0.1	0.8	1.6	-0.5	-0.4	0.9	-0.9	-1.3	-1.0
Arm fat percentage (left)	0.1	0.4	1.6	-0.4	-0.4	-0.4	-0.6	-0.3	-1.3
Average weekly red wine intake	0.5	0.7	1.8	-0.9	-1.0	-0.9	0.2	-1.3	-0.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.2	-0.4	-0.5	-1.4	2.0	-0.2	0.1
Mood swings	0.2	0.3	0.6	0.5	0.6	0.7	-0.2	0.8	0.3
Loneliness, isolation	0.5	0.7	3.1	-0.6	-0.1	-0.8	-0.1	-0.0	-1.8
Long-standing illness, disability or infirmity	0.6	0.9	5.0	-0.1	0.2	0.4	-0.5	0.3	-2.2
Ever had bowel cancer screening	0.5	0.5	1.3	-0.8	-0.3	-0.7	0.8	-0.3	-1.1
Diabetes diagnosed by doctor	0.8	1.3	5.1	-0.8	-0.7	-0.9	0.9	0.3	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	5.0	0.8	0.9	2.2	-1.3	0.9	0.1
Friendships satisfaction	0.6	0.7	1.8	-0.9	-0.7	-1.0	-0.1	-0.4	-1.3
Qualifications: nursing, teaching	0.5	0.7	1.1	-0.6	-1.0	-0.9	-0.6	-1.0	-0.9
Commuting to job workplace: Walk	0.4	0.4	1.0	-1.0	-0.6	0.3	0.2	0.3	-0.9
Eye problems/disorders: Cataract	1.1	1.2	2.8	-0.4	-1.0	-1.2	1.7	-0.2	1.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.6	0.5	0.5	1.6	-0.7	0.7	0.3
Medication for cholesterol	0.1	0.2	0.7	0.6	-0.0	-0.4	0.8	0.1	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	0.2	0.2	-1.0	0.3	0.7	0.5
Back pain experienced in last month	1.2	1.7	5.1	1.0	0.9	0.8	1.5	2.2	0.8
Mineral and other dietary supplements	0.7	0.9	3.3	0.1	0.4	0.9	0.1	0.9	-1.8
Breast cancer (self-reported)	1.2	1.5	3.3	-0.8	-1.3	-1.2	-0.5	-1.3	-1.8
Asthma (self-reported)	0.3	0.7	1.3	-0.7	-1.0	-0.6	-0.2	-1.0	-1.1
Osteoporosis (self-reported)	1.1	1.4	2.4	-1.0	-1.2	-0.7	-1.4	-1.5	1.0
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.2	0.0	0.3	0.4	0.4	0.7
Medication: Aspirin	0.2	0.3	0.6	-0.1	0.4	0.2	0.7	0.6	0.6
Medication: Gliclazide	2.1	2.4	3.9	1.5	2.0	1.9	-0.4	2.0	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	1.1	-0.4	-0.4	-0.3	-0.6	-1.0	-0.1
Smoking status: Current	0.2	0.2	0.7	-0.5	-0.8	-0.7	0.2	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.1	-0.4	-0.6	-0.8	-0.5	-0.3
Whole body water mass	0.3	1.8	4.2	-0.7	-0.8	0.8	-1.3	-2.1	-1.8
Leg predicted mass (right)	0.1	0.7	1.5	-0.4	-0.4	0.9	-0.8	-1.2	-0.9
Arm fat mass (left)	0.2	0.8	2.7	-0.5	-0.6	-0.3	-0.7	-1.0	-1.6
Number of self-reported non-cancer illnesses	0.7	1.2	5.8	-0.9	-0.5	-0.2	-0.1	-0.0	-2.4
Average weekly champagne plus white wine intake	4.1	5.6	8.6	1.5	2.7	2.2	2.6	2.9	1.9
Miserableness	0.1	0.2	0.5	-0.6	-0.3	0.1	-0.0	0.7	-0.7
Guilty feelings	0.2	0.3	1.1	-0.1	0.5	0.1	1.0	0.4	-0.3
Wears glasses or contact lenses	3.3	3.8	6.9	-1.9	-2.0	-1.8	1.3	-1.9	-2.6
Ever taken oral contraceptive pill	0.1	0.1	0.5	-0.7	-0.5	0.1	-0.2	-0.1	-0.1
Hearing aid user	0.3	0.3	0.7	0.3	-0.2	-0.1	0.7	-0.8	0.9
Mother’s age at death	1.2	1.5	2.3	-1.3	-1.5	-1.0	0.2	-1.4	-1.4
Financial situation satisfaction	0.3	0.3	0.8	0.6	0.4	-0.2	0.9	0.8	-0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.2	0.2	-0.1	-0.3	0.2	0.6
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.7	-0.5	-0.6	0.8	0.4	-0.4
Eye problems/disorders: Glaucoma	0.8	1.0	2.6	0.2	0.6	-0.5	1.5	0.7	1.6
Medication: Blood pressure	0.1	0.3	0.9	-0.3	0.4	1.0	-0.3	-0.3	-0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.7	0.2	-0.2	-0.4	-0.0	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.5	0.4	0.2	0.3	-0.0	-0.2	1.2
High cholesterol (Self-reported)	0.6	1.0	2.0	1.4	1.3	0.4	0.3	1.1	-0.8
Medication: Bendroflumethiazide	0.6	0.9	2.3	-0.2	0.7	1.5	-0.6	0.5	-1.3
Medication: Paracetamol	0.5	0.8	3.4	-1.0	-0.3	-0.3	-0.6	-0.1	-1.8
Medication: Lisinopril	0.3	0.4	0.7	0.5	0.3	0.7	0.8	-0.1	0.8
Medication: Atorvastatin	0.8	1.0	2.2	1.5	1.5	0.6	0.2	1.0	0.1
Illnesses of father: High blood pressure	0.9	1.1	2.1	-1.5	-0.7	-1.4	-0.7	-0.4	-1.1
Alcohol drinker status: Never	1.0	1.2	2.8	-1.1	-1.1	-1.0	-1.0	-1.7	0.3
Ever smoked	0.5	0.9	1.3	-1.0	-1.1	-1.1	-0.0	-0.9	-1.1
Basal metabolic rate	0.3	1.5	3.1	-0.5	-0.6	0.9	-1.2	-1.8	-1.7
Leg fat percentage (left)	0.4	1.4	3.8	-0.6	-1.0	-0.7	-1.1	-1.2	-1.9
Arm fat-free mass (left)	0.4	2.3	5.4	-0.8	-0.9	0.5	-1.2	-2.3	-2.2
Number of operations (self-reported)	0.8	1.2	1.9	-1.3	-1.4	-1.2	0.5	-0.4	-1.2
Average weekly beer plus cider intake	0.4	0.5	1.6	1.3	0.7	0.3	-0.7	0.3	0.8
Irritability	0.9	1.6	3.2	-1.8	-1.8	-1.3	1.2	-0.5	-0.0
Risk taking	0.5	0.7	2.5	-0.5	-0.6	-0.8	0.3	-0.4	1.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.7	-0.1	0.6	0.5	0.5	-0.1
Fractured/broken bones in last 5 years	1.0	1.3	4.2	-1.6	-1.0	-0.1	-0.2	-0.2	-2.1
Age started oral contraceptive pill	1.6	1.9	4.9	-1.4	-1.5	-1.5	0.1	-2.2	-0.5
Diastolic blood pressure, automated reading	0.1	0.3	1.1	1.1	0.7	0.0	0.3	0.4	-0.2
Ever depressed for a whole week	1.6	2.0	5.9	1.2	1.1	0.7	1.6	2.4	0.7
Unable to work because of sickness or disability	0.7	0.9	1.7	-1.3	-1.3	-1.3	0.1	-0.3	-0.4
Commuting to job workplace: Cycle	0.6	0.8	2.3	1.1	0.4	1.5	-0.7	0.7	0.3
Myopia	0.4	0.6	1.4	0.1	0.9	1.2	-0.6	0.7	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	-0.1	-1.0	-1.2	-0.5	-1.3	0.7
Cholesterol lowering medication	1.5	2.2	5.0	-0.8	-0.6	-1.6	-2.2	-1.7	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	-0.4	-0.5	-0.9	0.6	-0.2	0.2
Pain experienced in last month	1.1	1.8	2.6	-1.4	-1.4	-1.4	-1.6	-1.6	-0.2
Supplements: Calcium	1.3	1.5	6.0	0.9	1.1	0.7	0.3	0.5	2.4
Basal cell carcinoma (self-reported)	0.9	1.0	3.2	-0.5	-1.1	-0.6	-0.6	-1.8	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.1	0.3	0.3	1.0	0.7	1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.5	-1.2	-0.9	-0.6	-0.6	-0.6	-1.2
Heart disease (siblings)	0.9	1.1	1.9	1.2	1.0	1.2	0.4	1.4	-0.7
Alcohol drinker status: Previous	0.5	0.6	1.3	0.3	0.8	1.1	0.6	0.7	0.9
Pack years of smoking	0.2	0.3	1.1	0.3	0.1	0.5	-0.2	0.5	-1.0
Impedance of whole body	0.2	0.8	2.3	-0.4	0.0	-1.0	1.1	1.5	0.5
Leg fat mass (left)	0.5	1.9	4.6	-0.9	-1.2	-0.6	-1.3	-1.6	-2.1
Arm predicted mass (left)	0.4	1.9	5.0	-0.6	-0.9	0.5	-1.1	-2.2	-1.9