TWAS hub - CECR6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1069	0.0264	7.5e-07	0.062	0.040	0.054	0.057	0.051	1.1e-09	1.0e-06	1.3e-08	5.8e-09	4.3e-08
2	NTR	Blood	0.0778	0.0153	4.6e-12	0.066	0.053	0.062	0.067	0.067	2.2e-20	9.2e-17	2.6e-19	1.4e-20	1.4e-20
3	YFS	Blood	0.4996	0.0274	0.0e+00	0.280	0.497	0.517	0.509	0.493	2.3e-92	9.6e-191	5.9e-202	5.9e-197	1.7e-188
4	TCGA	Colon Adenocarcinoma	0.1530	0.0680	4.6e-03	0.026	0.061	0.053	NA	0.022	1.2e-02	1.9e-04	5.3e-04	NA	1.8e-02
5	TCGA	Lung Adenocarcinoma	0.0478	0.0196	7.4e-05	0.032	0.035	0.029	NA	0.035	1.2e-04	4.9e-05	2.0e-04	NA	5.7e-05
6	TCGA	Lung Squamous Cell Carcinoma	0.0424	0.0257	9.7e-03	0.047	0.010	0.007	NA	0.038	4.2e-06	2.3e-02	4.7e-02	NA	3.3e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Schizophrenia vs Biploar Disorder	5.7	7.5	8.7	-2.2	-2.9	-2.6	-2.9	-2.9	-2.8
Hearing difficulty/problems with background noise	4.8	7.6	15.1	-2.7	-2.3	-1.8	-3.0	-2.5	-3.9
Crohns Disease (2012)	4.3	6.9	11.7	-2.9	-3.4	-3.4	-0.8	-2.6	-1.7
Average weekly champagne plus white wine intake	4.1	5.6	8.6	1.5	2.7	2.2	2.6	2.9	1.9
Blood White Count	3.8	28.4	58.1	-7.6	-6.3	-4.9	0.8	-1.9	-6.6
Wears glasses or contact lenses	3.3	3.8	6.9	-1.9	-2.0	-1.8	1.3	-1.9	-2.6
Chest pain or discomfort	2.7	3.9	14.3	-1.5	-1.9	-0.3	-1.3	-1.3	-3.8
Mean Putamen Volume	2.6	3.0	6.3	2.5	2.2	2.1	-0.2	1.5	0.5
Supplements: Glucosamine	2.5	3.3	6.2	-1.4	-2.4	-2.4	0.1	-2.5	-0.1
Breastfed as a baby	2.5	3.1	5.9	-1.6	-1.7	-1.6	-0.6	-2.1	-2.4
Had other major operations	2.4	3.0	5.0	-1.8	-2.1	-1.9	-0.9	-2.2	-0.8
Medication: Gliclazide	2.1	2.4	3.9	1.5	2.0	1.9	-0.4	2.0	-0.8
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.0	-2.0	-1.8	-1.6	-0.2	-1.9	-1.3
Chronic bronchitis/emphysema (mother)	1.8	2.1	4.2	1.8	2.0	1.8	-0.2	1.3	0.5
Ever unenthusiastic/disinterested for a whole week	1.7	2.0	6.5	0.5	1.1	-0.0	2.5	1.7	1.2
Medication: Ramipril	1.7	2.2	7.9	-1.7	-0.9	-0.8	-0.9	-0.5	-2.8
Ovarian Cancer	1.6	2.1	4.2	2.0	2.0	1.0	-0.2	1.7	0.7
Blood Eosinophil Count	1.6	12.1	24.0	-4.9	-4.2	-3.1	1.3	-0.9	-4.3
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.8	-1.2	-1.6	-1.9	0.1	-1.7	-1.4
Depression (self-reported)	1.6	1.9	5.0	1.3	1.5	2.2	0.3	1.3	0.5
Age started oral contraceptive pill	1.6	1.9	4.9	-1.4	-1.5	-1.5	0.1	-2.2	-0.5
Ever depressed for a whole week	1.6	2.0	5.9	1.2	1.1	0.7	1.6	2.4	0.7
Smoking Status	1.5	3.5	6.4	-2.2	-2.5	-2.5	1.5	-1.2	-0.5
Allergy	1.5	3.4	6.9	1.9	2.0	1.1	1.0	1.9	2.6
Pulse wave reflection index	1.5	1.8	3.5	1.4	1.9	1.3	-0.0	1.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.0	1.5	1.2	2.0	-0.4	1.7	0.2
Cholesterol lowering medication	1.5	2.2	5.0	-0.8	-0.6	-1.6	-2.2	-1.7	-1.2
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	2.7	-1.6	-1.5	-0.8	-1.4	-1.2	-1.5
Medication: Lansoprazole	1.4	1.6	4.0	0.9	0.8	1.0	2.0	1.4	0.9
Worry too long after embarrassment	1.4	2.3	4.8	0.9	1.9	1.3	1.0	2.2	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.0	1.1	1.7	1.2	0.0	-0.1	2.0
Health satisfaction	1.4	1.8	2.4	-1.4	-1.6	-1.6	1.2	-1.4	-0.7
Comparative height size at age 10	1.4	7.7	11.4	-3.3	-3.4	-2.6	-0.0	-3.4	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	5.0	0.8	0.9	2.2	-1.3	0.9	0.1
HDL Cholesterol	1.3	2.2	4.9	-1.4	-1.6	-1.8	0.1	-2.2	-0.6
Father’s age at death	1.3	1.8	3.4	-1.4	-1.3	-1.8	-0.2	-1.1	-1.6
Number of live births	1.3	1.9	3.4	-1.5	-1.9	-1.4	-0.5	-1.2	-1.4
Glaucoma (self-reported)	1.3	1.5	3.6	0.9	1.1	0.2	1.9	1.1	1.5
Supplements: Calcium	1.3	1.5	6.0	0.9	1.1	0.7	0.3	0.5	2.4
Coronary Artery Disease (CAD)	1.2	1.4	2.9	1.2	0.9	1.7	0.5	0.6	1.6
Serious illness, injury or assault to yourself	1.2	1.5	3.7	-1.9	-1.4	-0.9	0.2	0.1	-1.6
Back pain experienced in last month	1.2	1.7	5.1	1.0	0.9	0.8	1.5	2.2	0.8
Breast cancer (self-reported)	1.2	1.5	3.3	-0.8	-1.3	-1.2	-0.5	-1.3	-1.8
Mother’s age at death	1.2	1.5	2.3	-1.3	-1.5	-1.0	0.2	-1.4	-1.4
Hair/balding pattern: Pattern 2	1.1	1.4	4.6	-1.4	-0.8	-0.2	1.0	0.4	-2.1
Number of full brothers	1.1	1.4	3.2	1.1	0.9	1.8	-0.6	1.7	-0.1
Eye problems/disorders: Cataract	1.1	1.2	2.8	-0.4	-1.0	-1.2	1.7	-0.2	1.4
Osteoporosis (self-reported)	1.1	1.4	2.4	-1.0	-1.2	-0.7	-1.4	-1.5	1.0
Pain experienced in last month	1.1	1.8	2.6	-1.4	-1.4	-1.4	-1.6	-1.6	-0.2
Relative age of first facial hair	1.0	2.1	4.2	1.0	1.4	1.4	1.4	2.0	1.1
Taking other prescription medications	1.0	1.5	2.7	-1.3	-1.4	-0.1	-1.2	-1.1	-1.7
Medication: Atenolol	1.0	1.2	2.6	1.1	1.6	0.1	0.7	1.6	0.7
Diabetes (self-reported)	1.0	1.5	6.6	-0.9	-0.8	-1.1	0.1	-0.1	-2.6
Length of working week for main job	1.0	1.1	2.6	1.6	1.4	1.2	0.0	-0.1	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.4	1.4	1.1	1.1	0.2	1.6	-0.4
Smoking status: Previous	1.0	1.5	2.9	-1.1	-1.1	-1.5	0.4	-1.7	-1.0
Alcohol drinker status: Never	1.0	1.2	2.8	-1.1	-1.1	-1.0	-1.0	-1.7	0.3
Fractured/broken bones in last 5 years	1.0	1.3	4.2	-1.6	-1.0	-0.1	-0.2	-0.2	-2.1
Crohns Disease (2017)	0.9	2.0	2.9	-1.2	-1.7	-1.6	-1.2	-1.4	-1.2
Body Mass Index (BMI) (2010)	0.9	1.2	3.2	-0.7	-1.0	-0.3	-1.6	-1.8	-0.2
Triglycerides	0.9	1.4	2.9	1.2	1.3	1.6	0.2	1.7	0.1
Vitamin and mineral supplements	0.9	1.2	5.5	0.5	-0.0	0.6	-1.0	0.5	-2.3
Medication: Co-codamol	0.9	1.0	2.3	0.7	0.7	0.5	1.4	1.5	0.8
Medication: Metformin	0.9	1.3	5.7	-0.5	-0.9	-0.9	-0.3	0.2	-2.4
Diabetes (mother)	0.9	1.1	2.8	1.7	1.1	1.2	0.8	0.0	-0.6
Multivitamins +/- minerals	0.9	1.1	1.7	-1.1	-0.8	-1.3	0.9	-0.8	1.2
Had menopause	0.9	1.1	3.3	-0.4	-0.8	-1.4	0.6	-1.8	0.5
Noisy workplace	0.9	1.1	3.6	-0.9	-1.0	0.1	-0.6	-0.8	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.1	1.5	1.4	1.0	0.4	1.0	0.6
Eye problems/disorders: None of the above	0.9	1.1	4.1	0.0	0.1	1.3	-2.0	-0.4	-0.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.2	-0.4	-0.5	-1.4	2.0	-0.2	0.1
Illnesses of father: High blood pressure	0.9	1.1	2.1	-1.5	-0.7	-1.4	-0.7	-0.4	-1.1
Irritability	0.9	1.6	3.2	-1.8	-1.8	-1.3	1.2	-0.5	-0.0
Basal cell carcinoma (self-reported)	0.9	1.0	3.2	-0.5	-1.1	-0.6	-0.6	-1.8	-0.8
Heart disease (siblings)	0.9	1.1	1.9	1.2	1.0	1.2	0.4	1.4	-0.7
Rheumatoid Arthritis	0.8	1.1	3.1	0.7	0.5	-0.3	1.8	0.4	1.4
Schizophrenia (2014)	0.8	1.7	2.6	-1.1	-1.5	-0.8	-1.5	-1.0	-1.6
Average weekly spirits intake	0.8	1.0	2.0	1.2	1.4	0.8	0.6	0.8	0.8
Angina	0.8	1.0	2.7	1.0	0.8	0.5	-1.0	1.6	-0.7
Peak expiratory flow (PEF)	0.8	1.9	4.6	1.7	1.8	2.1	-0.5	0.2	0.5
Blood clot in the leg (DVT)	0.8	1.1	2.0	-1.4	-1.0	-0.7	-0.5	-0.8	-1.4
Number of full sisters	0.8	1.0	2.6	0.8	0.6	1.4	0.1	1.6	0.4
Family relationship satisfaction	0.8	1.0	4.1	-0.6	-0.1	-0.9	2.0	0.8	0.0
Illnesses of father: Heart disease	0.8	1.1	2.0	1.3	1.0	1.3	0.2	1.4	0.6
Illnesses of siblings: Diabetes	0.8	1.0	2.1	-1.2	-0.3	0.0	-1.3	-1.4	-0.8
Diabetes diagnosed by doctor	0.8	1.3	5.1	-0.8	-0.7	-0.9	0.9	0.3	-2.3
Eye problems/disorders: Glaucoma	0.8	1.0	2.6	0.2	0.6	-0.5	1.5	0.7	1.6
Medication: Atorvastatin	0.8	1.0	2.2	1.5	1.5	0.6	0.2	1.0	0.1
Number of operations (self-reported)	0.8	1.2	1.9	-1.3	-1.4	-1.2	0.5	-0.4	-1.2
HbA1C	0.7	0.8	1.8	0.6	1.3	1.2	-0.2	1.0	-0.5
Respiratory disease	0.7	1.6	2.5	-1.2	-1.4	-0.9	-0.8	-1.5	-1.6
Supplements: Zinc	0.7	0.8	1.2	-1.0	-1.1	-0.8	-1.1	-0.4	-0.8
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.2	-1.2	-1.2	-1.0	-0.8	-1.2	-1.8
Stomach or abdominal pain in last month	0.7	0.9	1.8	-1.1	-1.1	-1.3	0.9	-0.2	-0.2
High blood pressure (mother)	0.7	0.9	2.4	0.5	1.1	0.8	-1.6	0.4	-0.9
Number of incorrect matches in round	0.7	1.1	2.4	-1.4	-1.1	-1.0	-0.3	-1.5	0.1
Past tobacco smoking	0.7	1.3	2.2	1.1	1.1	1.4	-0.4	1.5	1.0
Alcohol usually taken with meals	0.7	1.1	2.9	0.3	0.4	0.8	-1.6	-0.2	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.1	0.4	0.5	0.8	-1.2	0.5	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.9	0.4	0.6	1.1	1.2	1.7	0.5
Birth weight of first child	0.7	1.3	1.8	-1.0	-1.3	-1.3	-1.1	-1.2	-0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	4.0	-0.7	0.1	0.9	0.2	0.6	-2.0
Qualifications: College or University degree	0.7	2.2	6.4	-1.5	-1.4	-1.1	-0.1	-1.2	-2.5
Leg fat mass (right)	0.7	2.7	6.3	-1.3	-1.6	-0.9	-1.2	-1.7	-2.5
Age at last live birth	0.7	1.0	1.7	-1.2	-1.2	-1.3	0.8	-0.1	-0.8
Mineral and other dietary supplements	0.7	0.9	3.3	0.1	0.4	0.9	0.1	0.9	-1.8
Number of self-reported non-cancer illnesses	0.7	1.2	5.8	-0.9	-0.5	-0.2	-0.1	-0.0	-2.4
Unable to work because of sickness or disability	0.7	0.9	1.7	-1.3	-1.3	-1.3	0.1	-0.3	-0.4
Alzheimer’s Disease (in mother)	0.6	0.7	2.8	0.0	-0.1	-0.7	-1.0	-0.3	-1.7
Alzheimer’s Disease (including proxy)	0.6	0.8	2.5	0.4	-0.2	0.0	-1.3	-0.6	-1.6
Primary Biliary Cirrhosis	0.6	0.9	3.1	-0.5	-0.7	-0.9	0.4	-0.7	-1.8
Waist Hip Ratio (WHR)	0.6	2.6	6.5	-1.6	-2.6	-1.8	1.5	0.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.4	0.5	1.0	1.5	-0.3	0.8	-0.2
Relative age voice broke	0.6	0.9	1.7	-1.1	-1.2	-0.6	1.3	0.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	-1.1	-1.3	-0.2	1.0	-0.3	0.6
Qualifications: CSEs or equivalent	0.6	0.8	3.0	0.9	0.6	0.7	0.5	0.4	1.7
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	1.0	1.0	0.4	0.5	0.4	-1.3
Hair/balding pattern: Pattern 3	0.6	0.9	2.6	0.7	0.7	1.0	-1.6	1.0	-0.2
Illnesses of mother	0.6	0.8	1.9	0.3	0.3	0.6	0.9	1.4	1.2
High blood pressure (siblings)	0.6	0.8	1.6	0.9	1.0	0.6	-1.3	-0.1	-1.1
Leg fat percentage (right)	0.6	2.3	5.8	-1.0	-1.5	-1.2	-1.0	-1.4	-2.4
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	-1.0	-1.4	-0.9	-0.2	-1.3	-0.7
Angina (self-reported)	0.6	0.8	1.7	0.8	0.5	0.3	-1.0	1.3	-1.0
Medication: Ibuprofen	0.6	0.7	1.4	1.2	1.0	0.8	0.4	0.8	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	-0.5	-0.6	-0.1	1.5	-0.3	1.1
Supplements: Vitamin C	0.6	0.7	1.8	-0.1	-0.2	-0.4	-0.8	-1.4	1.2
Long-standing illness, disability or infirmity	0.6	0.9	5.0	-0.1	0.2	0.4	-0.5	0.3	-2.2
Friendships satisfaction	0.6	0.7	1.8	-0.9	-0.7	-1.0	-0.1	-0.4	-1.3
High cholesterol (Self-reported)	0.6	1.0	2.0	1.4	1.3	0.4	0.3	1.1	-0.8
Medication: Bendroflumethiazide	0.6	0.9	2.3	-0.2	0.7	1.5	-0.6	0.5	-1.3
Commuting to job workplace: Cycle	0.6	0.8	2.3	1.1	0.4	1.5	-0.7	0.7	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.5	-1.2	-0.9	-0.6	-0.6	-0.6	-1.2
Reaction Time	0.5	0.9	2.4	0.1	0.7	1.1	-0.4	1.5	1.1
Age at First Birth	0.5	0.8	1.7	-0.9	-0.7	-1.0	1.3	-0.2	-0.8
Fasting Glucose	0.5	0.6	1.2	-0.8	-0.5	-1.1	0.2	-1.0	0.7
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	0.5	0.2	0.4	-1.0	-1.2	-0.7
Neuroticism	0.5	1.1	2.4	-1.3	-0.5	-0.9	1.2	0.2	-1.6
Ever had hysterectomy (womb removed)	0.5	0.5	1.7	-1.3	-0.7	-0.8	-0.2	-0.6	-0.1
Severe depression (siblings)	0.5	0.5	2.5	0.1	0.3	0.6	0.3	0.4	-1.6
Maternal smoking around birth	0.5	0.7	1.7	0.8	0.7	1.0	-1.3	0.1	0.4
Waist circumference	0.5	1.8	4.1	-1.1	-1.4	-1.1	-0.3	-1.5	-2.0
Pain all over the body in last month	0.5	0.5	1.7	0.4	-0.3	0.4	-0.8	-0.5	-1.3
Fluid intelligence score	0.5	0.9	2.8	-0.2	-0.8	0.0	-1.7	-0.9	-1.2
Neuroticism score	0.5	1.0	2.0	-1.4	-0.5	-0.8	1.1	0.1	-1.3
Falls in the last year	0.5	0.7	2.3	-0.7	-0.5	-0.9	-0.3	-1.5	-0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.1	-1.0	-1.0	0.6	-1.4	-0.1	-1.4
Asthma	0.5	0.9	1.6	-0.9	-1.2	-0.7	-0.1	-1.0	-1.1
Medication: Cholesterol lowering	0.5	0.7	3.2	-0.2	-0.2	-0.6	0.6	0.5	-1.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.8	-0.3	-0.1	0.3	1.7	0.8	-0.1
Arm fat-free mass (right)	0.5	2.5	6.5	-0.8	-1.1	0.5	-1.3	-2.6	-2.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	-0.8	-0.7	-1.1	0.7	-0.3	-0.8
Overall health rating	0.5	1.1	1.9	1.2	0.7	0.8	1.0	1.4	-1.0
Had major operations	0.5	0.6	1.4	0.2	0.9	0.1	1.0	1.2	0.4
Average weekly red wine intake	0.5	0.7	1.8	-0.9	-1.0	-0.9	0.2	-1.3	-0.4
Loneliness, isolation	0.5	0.7	3.1	-0.6	-0.1	-0.8	-0.1	-0.0	-1.8
Ever had bowel cancer screening	0.5	0.5	1.3	-0.8	-0.3	-0.7	0.8	-0.3	-1.1
Qualifications: nursing, teaching	0.5	0.7	1.1	-0.6	-1.0	-0.9	-0.6	-1.0	-0.9
Medication: Paracetamol	0.5	0.8	3.4	-1.0	-0.3	-0.3	-0.6	-0.1	-1.8
Ever smoked	0.5	0.9	1.3	-1.0	-1.1	-1.1	-0.0	-0.9	-1.1
Risk taking	0.5	0.7	2.5	-0.5	-0.6	-0.8	0.3	-0.4	1.6
Alcohol drinker status: Previous	0.5	0.6	1.3	0.3	0.8	1.1	0.6	0.7	0.9
Leg fat mass (left)	0.5	1.9	4.6	-0.9	-1.2	-0.6	-1.3	-1.6	-2.1
Bipolar Disorder (2018)	0.4	0.7	2.4	-0.4	-0.4	-0.4	0.6	1.0	-1.6
Alzheimer’s Disease (in father)	0.4	0.5	1.1	0.7	0.8	1.1	-0.2	0.3	-0.6
Major Depression (MDD)	0.4	0.5	1.1	0.6	0.4	1.0	0.5	1.0	0.1
Blood Red Count	0.4	3.7	9.1	-1.2	-1.6	-0.7	-2.2	-1.9	-3.0
Allergy or Eczema	0.4	0.9	4.3	-0.1	0.2	0.9	-0.5	0.5	-2.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.7	1.3	0.4	0.5	0.1	0.5	-0.7
Medication for hormone replacement therapy	0.4	0.4	1.5	-1.2	-0.9	-0.2	-0.4	-0.2	0.1
Pack years adult smoking proportion	0.4	0.6	1.0	0.8	0.5	1.0	-0.4	0.8	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	0.8	0.8	0.3	0.6	0.8	-0.4
High blood pressure	0.4	1.2	2.3	0.5	1.5	1.5	0.7	1.2	-0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	-0.1	-0.8	-0.8	-0.8	-0.9	0.2
Illnesses of siblings	0.4	0.5	2.2	0.3	-0.1	-0.8	0.4	0.5	1.5
Trunk fat-free mass	0.4	2.4	5.7	-0.7	-0.9	0.8	-1.6	-2.4	-2.1
Hip circumference	0.4	1.8	3.7	-1.0	-1.0	-0.6	-1.3	-1.7	-1.9
Worrier / anxious feelings	0.4	0.8	1.9	0.4	1.0	1.1	0.7	1.4	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.0	1.3	1.2	1.7	-1.0	0.0	0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	1.1	1.1	-0.4	0.9	0.3	0.7
Lung cancer (father)	0.4	0.5	1.2	0.6	0.9	0.6	-0.4	1.1	0.2
Trunk predicted mass	0.4	2.5	6.0	-0.8	-0.9	0.8	-1.6	-2.5	-2.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	0.8	0.4	1.0	-0.4	-0.1	1.2
Headache pain in last month	0.4	0.7	1.2	0.7	0.6	1.1	-1.1	0.6	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.4	0.9	0.5	0.7	0.1	0.0	1.5
Number of children fathered	0.4	0.5	1.5	-0.9	-0.6	0.1	0.4	-0.2	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.9	-0.0	-0.4	-0.6	-0.0	-0.4	-1.4
Arm predicted mass (right)	0.4	2.0	5.1	-0.5	-1.0	0.9	-1.3	-2.3	-1.9
Leg pain on walking	0.4	0.5	1.0	-0.7	-0.6	-0.7	-1.0	-0.2	-0.9
Knee pain experienced in last month	0.4	0.5	1.8	0.2	0.4	0.6	1.3	1.0	-0.1
Commuting to job workplace: Walk	0.4	0.4	1.0	-1.0	-0.6	0.3	0.2	0.3	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.6	0.5	0.5	1.6	-0.7	0.7	0.3
Leg fat percentage (left)	0.4	1.4	3.8	-0.6	-1.0	-0.7	-1.1	-1.2	-1.9
Arm fat-free mass (left)	0.4	2.3	5.4	-0.8	-0.9	0.5	-1.2	-2.3	-2.2
Average weekly beer plus cider intake	0.4	0.5	1.6	1.3	0.7	0.3	-0.7	0.3	0.8
Myopia	0.4	0.6	1.4	0.1	0.9	1.2	-0.6	0.7	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.1	0.3	0.3	1.0	0.7	1.1
Arm predicted mass (left)	0.4	1.9	5.0	-0.6	-0.9	0.5	-1.1	-2.2	-1.9
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	-0.8	-0.9	-0.7	0.4	0.5	-1.3
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	-1.1	-0.8	-0.7	-0.9	0.1	-1.0
Irritable Bowel Disease (IBD)	0.3	0.7	1.1	-0.8	-1.0	-0.7	-1.0	-0.1	-1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.5	-0.2	-0.7	-0.3	-1.6	-0.6	-1.0
Prostate Cancer	0.3	0.4	1.1	0.6	0.8	0.1	1.0	0.4	0.5
Lupus	0.3	0.4	0.8	-0.9	-0.7	-0.8	-0.7	0.0	0.4
Neuroticism (2016)	0.3	0.4	1.2	-0.6	0.4	0.5	0.6	0.6	-1.1
Chronotype (morning person)	0.3	0.7	2.6	-0.0	0.4	-0.4	-1.0	-0.3	-1.6
Hand grip strength (right)	0.3	0.8	1.8	0.5	0.5	1.3	-0.9	-0.1	-1.2
Age when periods started (menarche)	0.3	0.8	1.7	-1.2	-1.2	-1.3	0.2	-0.3	0.1
Nervous feelings	0.3	0.6	1.7	-0.7	-0.0	0.2	1.2	1.3	0.3
Financial difficulties in last 2 years	0.3	0.5	2.0	0.3	0.5	0.3	-1.4	0.3	0.5
Heart attack	0.3	0.4	1.0	-0.0	0.2	0.3	0.9	0.7	1.0
Medication: Simvastatin	0.3	0.4	1.9	0.4	0.2	-0.2	-0.6	-0.0	-1.4
Weight	0.3	1.5	4.4	-0.7	-0.8	0.1	-0.8	-1.6	-2.1
Impedance of arm (right)	0.3	1.4	3.7	-0.6	0.1	-1.1	1.7	1.9	0.7
Pulse rate	0.3	0.5	0.9	0.5	-0.5	-1.0	-0.9	-0.8	-0.4
Standing height	0.3	3.0	5.3	-2.2	-1.7	-0.3	-0.5	-2.3	-2.2
Loud music exposure frequency	0.3	0.3	0.7	0.7	0.1	-0.4	0.9	0.7	0.0
Gout (self-reported)	0.3	0.4	1.4	0.0	-0.7	0.2	-1.2	-0.6	-0.3
Medication: Amlodipine	0.3	0.4	0.8	0.7	0.9	0.2	0.7	0.3	-0.4
Age at first live birth	0.3	0.5	1.0	-0.5	-0.6	-0.9	0.6	0.1	-1.0
Shortness of breath walking on level ground	0.3	0.4	1.0	-0.2	-0.3	-0.3	-1.0	-0.6	-0.8
Emphysema/chronic bronchitis	0.3	0.3	1.1	-0.2	-0.1	0.5	-1.0	0.1	-0.6
Neck or shoulder pain in last month	0.3	0.5	1.6	0.2	0.0	-0.2	1.3	0.5	-0.9
Migraine (self-reported)	0.3	0.4	0.7	-0.8	-0.4	-0.8	-0.1	0.1	-0.8
Medication: Seretide 50 evohaler	0.3	0.3	1.3	-0.1	-0.2	-1.2	0.5	-0.4	0.5
Mean time to correctly identify matches	0.3	0.5	1.1	-0.2	0.6	1.1	-0.0	0.8	0.9
Suffer from ‘nerves’	0.3	0.4	0.9	-1.0	-0.3	-0.5	0.2	-0.7	-0.9
Whole body fat-free mass	0.3	1.8	4.2	-0.6	-0.8	0.9	-1.4	-2.0	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	0.2	0.2	-1.0	0.3	0.7	0.5
Asthma (self-reported)	0.3	0.7	1.3	-0.7	-1.0	-0.6	-0.2	-1.0	-1.1
Illnesses of father: None of the above (group 1)	0.3	0.3	1.1	-0.4	-0.4	-0.3	-0.6	-1.0	-0.1
Whole body water mass	0.3	1.8	4.2	-0.7	-0.8	0.8	-1.3	-2.1	-1.8
Hearing aid user	0.3	0.3	0.7	0.3	-0.2	-0.1	0.7	-0.8	0.9
Financial situation satisfaction	0.3	0.3	0.8	0.6	0.4	-0.2	0.9	0.8	-0.0
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.7	-0.5	-0.6	0.8	0.4	-0.4
Medication: Lisinopril	0.3	0.4	0.7	0.5	0.3	0.7	0.8	-0.1	0.8
Basal metabolic rate	0.3	1.5	3.1	-0.5	-0.6	0.9	-1.2	-1.8	-1.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	-0.1	-1.0	-1.2	-0.5	-1.3	0.7
Depression (Nagel 2018)	0.2	0.3	0.8	-0.9	-0.5	-0.1	-0.4	-0.1	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.3	0.9	0.2	0.7	-1.5	0.1	-0.8
Neuroticism (Nagel 2018)	0.2	0.5	2.0	-0.6	0.1	-0.0	0.5	1.4	-0.8
Schizophrenia (2018)	0.2	0.4	0.9	-0.9	-0.9	-0.5	-0.0	-0.2	-0.5
Worry (Nagel 2018)	0.2	0.5	1.2	-1.1	-0.3	-0.4	1.0	0.3	-0.6
Ulcerative Colitis (UC)	0.2	0.3	0.6	-0.2	-0.1	0.5	-0.6	0.7	-0.8
Breast Cancer	0.2	0.6	1.8	1.4	1.1	0.3	-0.4	0.2	0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.3	0.6	0.2	-0.2	-0.7	0.1	-1.1
Hand grip strength (left)	0.2	0.5	1.2	-0.4	-0.3	-0.0	-0.5	-1.1	-1.1
Number of treatments/medications taken	0.2	0.4	1.0	-1.0	-0.6	0.1	0.3	0.2	-1.0
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.5	0.1	0.3	-0.3	0.9	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.6	0.2	0.7	0.4	-0.1	0.8	0.2
Hearing difficulty/problems: Yes	0.2	0.4	0.8	-0.9	-0.0	0.5	-0.6	-0.7	-0.4
Diabetes (father)	0.2	0.2	0.5	-0.6	-0.2	-0.4	-0.7	0.4	0.3
Leg fat-free mass (left)	0.2	0.9	1.8	-0.7	-0.7	0.7	-0.8	-1.3	-1.3
Average weekly fortified wine intake	0.2	0.3	1.1	-0.3	-0.5	-0.5	0.0	-1.0	0.0
Fed-up feelings	0.2	0.4	1.5	-1.2	-0.6	-0.2	-0.9	0.0	-0.1
Leg predicted mass (left)	0.2	1.0	2.2	-0.8	-0.8	0.6	-0.8	-1.5	-1.3
Trunk fat mass	0.2	0.7	2.5	-0.7	-0.6	-0.4	-0.5	-0.8	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	-0.8	-0.1	0.7	-0.6	-0.4	0.2
Forced vital capacity (FVC)	0.2	0.6	1.5	0.7	0.4	0.9	-1.2	-0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.4	0.4	1.0	0.7	0.8	-0.2
Mouth/teeth dental problems	0.2	0.3	0.8	0.2	-0.4	-0.2	-0.3	-0.9	0.9
Time employed in main current job	0.2	0.3	0.7	-0.6	-0.2	-0.2	-0.5	-0.5	0.8
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.2	-0.1	0.4	-0.6	-0.7	0.7
Happiness	0.2	0.3	0.6	-0.2	0.1	-0.7	0.8	0.5	-0.6
Prospective memory result	0.2	0.3	1.1	-0.5	-0.6	-1.0	0.3	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.1	1.0	0.8	1.1	-0.7	0.2	0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.3	0.5	-0.5	-0.5	0.5	0.2
Impedance of arm (left)	0.2	1.1	3.4	0.1	0.6	-0.5	1.2	1.8	1.2
Arm fat mass (right)	0.2	0.8	2.5	-0.6	-0.6	-0.3	-0.8	-1.0	-1.6
Exposure to tobacco smoke at home	0.2	0.3	0.7	0.1	-0.8	-0.8	-0.1	-0.6	-0.0
Medication: Paracetamol	0.2	0.4	1.7	-0.1	0.3	-0.2	-0.4	0.4	-1.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	0.0	-0.7	-0.8	-0.5	-0.7	-0.2
Body fat percentage	0.2	0.7	2.2	-0.7	-0.7	-0.8	-0.6	-0.5	-1.5
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.7	-0.2	-0.7	0.2	-0.4	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.6	0.2	0.4	0.8	-0.3	0.1
Pulse wave peak to peak time	0.2	0.3	0.6	0.1	-0.7	0.3	0.6	-0.7	-0.4
Medication: Blood pressure	0.2	0.4	1.5	-0.5	0.2	-0.3	-0.6	-0.1	-1.2
Medication: Allopurinol	0.2	0.3	0.7	-0.2	-0.8	0.1	-0.5	0.0	-0.8
Medication: Omeprazole	0.2	0.2	0.4	-0.4	-0.1	-0.5	0.5	0.6	-0.1
Heart disease (mother)	0.2	0.3	0.6	0.8	0.3	0.4	0.8	0.0	0.1
Whole body fat mass	0.2	1.0	3.0	-0.8	-0.8	-0.4	-0.8	-0.9	-1.7
Pulse rate, automated reading	0.2	0.7	1.8	1.3	0.3	0.1	-1.3	-0.0	-0.7
Alcohol intake frequency.	0.2	0.5	1.7	0.4	0.5	0.9	-0.4	0.3	1.3
Medication: Aspirin	0.2	0.3	0.5	-0.1	0.4	0.4	0.6	0.6	0.7
Hypertension (Self-reported)	0.2	0.7	1.0	-0.0	1.0	1.0	1.0	1.0	-0.6
Mood swings	0.2	0.3	0.6	0.5	0.6	0.7	-0.2	0.8	0.3
Medication: Aspirin	0.2	0.3	0.6	-0.1	0.4	0.2	0.7	0.6	0.6
Smoking status: Current	0.2	0.2	0.7	-0.5	-0.8	-0.7	0.2	-0.1	0.1
Arm fat mass (left)	0.2	0.8	2.7	-0.5	-0.6	-0.3	-0.7	-1.0	-1.6
Guilty feelings	0.2	0.3	1.1	-0.1	0.5	0.1	1.0	0.4	-0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.7	0.2	-0.2	-0.4	-0.0	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.5	0.4	0.2	0.3	-0.0	-0.2	1.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.7	-0.1	0.6	0.5	0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	-0.4	-0.5	-0.9	0.6	-0.2	0.2
Pack years of smoking	0.2	0.3	1.1	0.3	0.1	0.5	-0.2	0.5	-1.0
Impedance of whole body	0.2	0.8	2.3	-0.4	0.0	-1.0	1.1	1.5	0.5
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.0	0.0	0.6	0.4	0.0
LDL Cholesterol	0.1	0.2	0.7	0.2	-0.2	0.4	0.1	0.5	-0.8
Blood Platelet Count	0.1	1.3	3.0	0.8	0.8	1.5	-0.7	1.0	-1.7
BMI	0.1	0.5	1.6	-0.0	-0.1	0.3	-0.7	-0.7	-1.3
Height	0.1	1.9	3.1	-1.2	-0.8	0.7	-1.7	-1.7	-1.8
Systolic Blood Pressure	0.1	0.3	0.8	0.1	0.2	-0.6	0.6	0.0	0.9
Cardiovascular Disease	0.1	0.5	2.5	-0.4	0.0	-0.2	-0.2	0.4	-1.6
Hypothyroidism (self reported)	0.1	0.3	0.8	-0.3	-0.7	-0.9	-0.2	-0.3	-0.4
Lung FVC	0.1	0.5	1.0	1.0	0.8	0.7	-0.5	0.2	-0.7
Tanning	0.1	0.7	2.0	-0.2	0.4	0.3	1.3	0.4	1.4
Systolic blood pressure, automated reading	0.1	0.3	0.6	0.1	0.1	-0.8	0.7	-0.3	-0.5
Impedance of leg (right)	0.1	0.4	1.3	-0.5	-0.7	-1.2	0.1	0.1	-0.4
Trunk fat percentage	0.1	0.3	1.0	-0.4	-0.4	-0.6	-0.1	-0.0	-1.0
Current tobacco smoking	0.1	0.1	0.3	-0.2	-0.6	-0.4	0.3	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.5	0.5	0.6	0.4	0.3	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.3	-0.3	-0.4
Sitting height	0.1	0.4	1.4	-0.5	-0.0	1.2	0.3	-0.6	-0.8
Body mass index (BMI)	0.1	0.6	1.9	0.1	-0.2	0.0	-0.8	-0.9	-1.4
Qualifications: None of the above	0.1	0.2	0.8	0.0	0.1	-0.2	0.9	0.3	0.1
Arm fat percentage (right)	0.1	0.5	1.9	-0.6	-0.5	-0.6	-0.5	-0.2	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.1	0.5	0.0	0.1	0.5	-0.8
Tense / ‘highly strung’	0.1	0.2	0.3	-0.0	0.6	0.6	0.5	0.0	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.7	0.3	0.7	-0.3	-0.2	0.2
Birth weight	0.1	0.2	0.8	-0.2	0.2	0.2	0.3	0.1	-0.9
Forced vital capacity (FVC), Best measure	0.1	0.2	0.6	0.4	0.3	0.6	-0.7	-0.3	-0.5
Comparative body size at age 10	0.1	0.4	1.3	1.2	0.2	-0.5	-0.4	0.6	-0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.7	0.2	0.7	-0.3	0.1	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.6	0.0	0.3	-0.2	-0.3	0.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.5	0.4	0.6	0.3	0.3	0.1
Leg fat-free mass (right)	0.1	0.8	1.6	-0.5	-0.4	0.9	-0.9	-1.3	-1.0
Arm fat percentage (left)	0.1	0.4	1.6	-0.4	-0.4	-0.4	-0.6	-0.3	-1.3
Medication for cholesterol	0.1	0.2	0.7	0.6	-0.0	-0.4	0.8	0.1	-0.0
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.2	0.0	0.3	0.4	0.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.1	-0.4	-0.6	-0.8	-0.5	-0.3
Leg predicted mass (right)	0.1	0.7	1.5	-0.4	-0.4	0.9	-0.8	-1.2	-0.9
Miserableness	0.1	0.2	0.5	-0.6	-0.3	0.1	-0.0	0.7	-0.7
Ever taken oral contraceptive pill	0.1	0.1	0.5	-0.7	-0.5	0.1	-0.2	-0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.2	0.2	-0.1	-0.3	0.2	0.6
Medication: Blood pressure	0.1	0.3	0.9	-0.3	0.4	1.0	-0.3	-0.3	-0.6
Diastolic blood pressure, automated reading	0.1	0.3	1.1	1.1	0.7	0.0	0.3	0.4	-0.2
Ulcerative Colitis	0.0	0.1	0.2	0.2	0.1	0.0	-0.2	0.5	-0.2
Heel T-Score	0.0	0.2	0.5	-0.1	0.1	0.6	0.7	0.4	-0.2
Lung FEV1/FVC ratio	0.0	0.2	0.8	0.3	0.1	0.2	-0.0	-0.9	0.0
Hair Pigment	0.0	0.3	0.5	0.5	0.2	0.7	-0.7	0.1	0.6
Townsend deprivation index at recruitment	0.0	0.1	0.2	-0.1	0.2	0.0	0.1	0.5	-0.1
Impedance of leg (left)	0.0	0.1	0.5	0.0	-0.1	-0.7	-0.0	0.5	0.0
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.2	-0.3	-0.1	-0.1	0.4	-0.0	0.3

Hub : Genes

CECR6

Models

Trait associations