Hub : Genes

CECR5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1550	0.0440	0.00050	0.019	NA	0.039	NA	0.036	1.0e-02	NA	3.4e-04	NA	6.0e-04
2	METSIM	Adipose	0.0926	0.0258	0.00012	0.051	0.038	0.062	0.039	0.060	3.7e-08	1.7e-06	1.1e-09	1.3e-06	2.2e-09
3	TCGA	Colon Adenocarcinoma	0.1450	0.0600	0.00160	0.073	0.019	0.096	NA	0.070	4.9e-05	2.8e-02	3.6e-06	NA	7.0e-05
4	TCGA	Pancreatic Adenocarcinoma	0.2540	0.0940	0.00051	0.004	0.085	0.058	NA	-0.004	2.0e-01	2.0e-04	2.0e-03	NA	5.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	2.8	-1.2	-0.2	0.0	-1.7
Bipolar Disorder or Schizophrenia	0.8	1.9	5.0	0.1	0.5	-1.6	-2.2
Depressed Affect (Nagel 2018)	0.7	1.6	4.2	-0.9	-0.8	-0.8	-2.0
Depression (Nagel 2018)	1.4	2.2	3.7	-1.2	-1.7	-0.8	-1.9
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.2	0.4	1.1	0.5	-0.1
Neuroticism (Nagel 2018)	0.6	1.3	2.8	-1.1	-1.0	0.5	-1.7
Schizophrenia (2018)	0.5	1.0	2.0	1.1	0.8	0.0	-1.4
Schizophrenia vs Biploar Disorder	1.1	1.4	5.5	0.5	2.4	0.0	-0.1
Worry (Nagel 2018)	0.3	0.6	1.5	-1.2	-0.7	0.3	-0.5
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	-0.3	1.0	-0.6	-0.4
Alzheimer’s Disease (in father)	0.3	0.3	1.0	0.0	0.4	-0.1	1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	-0.3	1.0	-0.4	0.6
Crohns Disease (2017)	0.0	0.0	0.1	0.1	-0.0	0.3	-0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.0	-0.3	0.5	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.5	-0.2	0.3	-0.6
Major Depression (MDD)	1.6	1.9	4.7	2.2	1.7	0.0	-0.1
Reaction Time	0.1	0.2	0.4	-0.4	-0.6	-0.6	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.3	1.0	1.8	0.8	0.5
Breast Cancer	0.1	0.3	0.5	0.4	0.6	0.7	-0.3
Ovarian Cancer	0.2	0.3	0.7	0.4	0.9	0.5	0.3
Prostate Cancer	0.1	0.1	0.2	-0.3	-0.1	0.0	-0.4
Age at First Birth	0.2	0.3	0.5	0.6	0.7	-0.3	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-0.9	0.7	0.2	1.2
Coronary Artery Disease (CAD)	0.5	0.6	2.2	0.6	0.1	0.0	1.5
Crohns Disease (2012)	0.2	0.3	0.7	-0.8	0.6	0.0	-0.4
Mean Putamen Volume	3.7	4.2	8.2	2.3	2.9	-0.2	1.9
Fasting Glucose	0.1	0.1	0.2	-0.2	0.4	0.5	0.2
HbA1C	0.5	0.6	1.1	0.8	0.0	1.1	-0.8
HDL Cholesterol	0.8	1.3	3.1	-0.2	-0.0	1.5	1.8
LDL Cholesterol	0.8	1.3	1.8	1.4	1.1	-1.2	-0.8
Lupus	1.7	2.6	6.4	-0.8	-2.5	1.4	-1.3
Neuroticism (2016)	0.3	0.4	0.8	-0.2	-0.8	-0.3	-0.9
Primary Biliary Cirrhosis	0.5	0.7	2.6	0.6	0.2	1.6	0.1
Rheumatoid Arthritis	1.0	1.4	2.5	-0.8	-0.4	1.6	1.6
Schizophrenia (2014)	0.5	1.1	2.5	0.8	1.6	0.0	-1.1
Triglycerides	1.2	2.0	5.7	2.4	1.4	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	-0.9	-0.3	0.0	1.1
Ulcerative Colitis	0.2	0.4	1.1	-1.1	-0.5	0.0	0.1
Blood Eosinophil Count	0.5	3.7	7.7	0.2	2.4	-1.2	-2.8
Blood Platelet Count	0.1	1.3	3.1	1.5	-0.0	-0.1	-1.8
Blood Red Count	0.1	1.2	3.2	-0.2	1.1	-0.5	-1.8
Blood White Count	1.1	7.9	26.8	-1.5	1.2	-1.0	-5.2
Heel T-Score	0.1	0.8	2.5	1.6	0.5	-0.4	-0.6
BMI	0.1	0.6	0.9	0.9	0.8	-0.9	-0.4
Height	0.1	2.6	7.9	-0.9	-0.4	-2.8	-1.1
Waist Hip Ratio (WHR)	0.3	1.4	1.8	1.1	1.3	1.3	-0.9
Systolic Blood Pressure	0.4	1.9	5.3	-0.4	-0.4	1.5	2.3
Smoking Status	0.3	0.7	2.0	-0.6	0.6	1.4	-0.0
Allergy or Eczema	0.5	1.4	5.1	-0.2	0.2	-0.6	-2.3
Cardiovascular Disease	0.1	0.3	1.1	1.1	0.5	-0.1	0.1
Hypothyroidism (self reported)	0.6	1.3	2.4	1.0	1.6	-0.8	-1.0
Respiratory disease	0.2	0.5	0.9	0.7	0.9	-0.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.1	0.7	1.4	-0.2	0.2
Lung FEV1/FVC ratio	0.4	1.9	3.3	1.2	1.8	-0.7	1.6
Lung FVC	0.3	1.4	4.1	-1.0	0.2	2.0	0.6
Neuroticism	0.5	1.3	3.2	-1.8	-1.1	0.7	-0.7
Chronotype (morning person)	1.3	3.0	7.6	-0.9	-0.0	-2.8	-1.9
Hair Pigment	0.0	0.6	1.6	0.4	0.8	-1.3	0.3
Tanning	0.2	2.0	4.0	0.4	-2.0	-1.3	-1.5
Hand grip strength (left)	0.8	2.2	4.2	1.5	2.0	-1.5	-0.0
Number of treatments/medications taken	0.1	0.2	0.3	-0.1	-0.5	-0.3	-0.5
Average weekly spirits intake	0.6	0.7	1.6	0.2	-0.7	1.3	0.7
Sensitivity / hurt feelings	0.4	0.7	2.2	-0.3	-0.4	0.6	-1.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.6	-0.4	-1.3	-0.4	-1.3
Hearing difficulty/problems: Yes	3.0	4.6	9.4	-1.9	-1.8	-3.1	-1.5
Relative age of first facial hair	0.5	1.0	2.2	-0.1	-1.3	0.0	-1.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.7	-0.5	0.6	0.8	0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	-0.4	-1.2	0.6	-0.4
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	-0.8	-1.2	0.8	-0.6
Systolic blood pressure, automated reading	0.8	2.4	4.7	-1.4	-1.4	2.2	0.9
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.4	1.1	1.3	-1.5	-0.2
Angina	0.6	0.8	1.4	1.2	0.7	-0.5	-1.0
Medication for hormone replacement therapy	0.4	0.5	0.7	0.5	-0.9	-0.6	-0.7
Vitamin and mineral supplements	0.7	0.9	1.7	0.3	0.6	-1.3	-1.3
Supplements: Zinc	0.3	0.3	0.7	0.2	0.5	0.8	-0.7
Medication: Co-codamol	0.3	0.3	0.8	0.4	-0.4	-0.9	-0.3
Medication: Metformin	0.6	0.8	2.4	-0.2	0.6	-0.6	-1.6
Diabetes (father)	0.1	0.1	0.2	-0.4	0.3	-0.2	-0.1
Diabetes (mother)	2.1	2.6	4.8	2.2	2.1	-0.3	1.1
Severe depression (siblings)	1.4	1.6	3.5	-0.4	-0.4	-1.9	-1.6
Pack years adult smoking proportion	0.4	0.7	1.4	0.7	0.7	-1.2	-0.4
Impedance of leg (right)	0.3	1.4	3.8	-0.6	-0.2	1.9	-1.2
Leg fat-free mass (left)	0.3	1.8	5.6	0.7	1.0	-2.4	-0.3
Trunk fat percentage	0.0	0.2	0.5	-0.0	0.4	-0.4	-0.7
Hand grip strength (right)	1.2	3.4	6.1	1.9	1.9	-2.5	-0.5
Townsend deprivation index at recruitment	0.4	0.6	1.0	-0.8	-0.4	0.8	1.0
Current tobacco smoking	0.3	0.5	1.3	-1.1	0.0	-0.0	-0.8
Average weekly fortified wine intake	0.4	0.5	0.8	-0.6	-0.9	0.1	0.8
Maternal smoking around birth	0.3	0.4	1.0	0.7	0.0	-1.0	-0.4
Fed-up feelings	0.1	0.2	0.8	-0.3	-0.1	0.1	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.5	0.2	-1.4	-1.2	-1.9
Relative age voice broke	0.6	0.9	1.7	-0.7	-0.9	1.3	-0.8
Taking other prescription medications	0.2	0.3	0.6	0.8	0.3	-0.1	-0.8
Age when periods started (menarche)	0.2	0.5	0.8	-0.9	-0.3	-0.9	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	0.3	-0.9	0.5	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	0.2	0.4	-0.5	-0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.1	-0.2	1.5	0.5	0.5
Qualifications: CSEs or equivalent	0.9	1.2	1.9	1.2	1.4	1.0	0.6
Serious illness, injury or assault to yourself	0.4	0.5	1.0	0.5	1.0	0.5	-0.6
High blood pressure	0.4	1.0	3.3	1.8	-0.7	0.4	-0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	-0.8	0.7	-0.5	-1.2
Multivitamins +/- minerals	0.3	0.4	0.9	-0.5	0.0	0.7	0.9
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.4	-0.1	0.8	-0.6
Supplements: Glucosamine	0.3	0.4	0.8	-0.2	-0.1	0.9	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	0.5	0.6	-1.3	-0.4
Medication: Atenolol	0.5	0.7	2.1	-0.1	-0.2	-1.5	0.6
Medication: Levothyroxine sodium	0.5	0.8	1.4	0.9	0.8	-0.6	-1.2
Sitting height	0.1	0.5	1.9	-0.1	-0.1	-1.4	-0.2
Chronic bronchitis/emphysema (father)	0.3	0.4	1.2	-1.1	-0.0	-0.5	-0.3
High blood pressure (mother)	0.5	0.6	2.0	0.1	1.4	-0.6	0.4
Body mass index (BMI)	0.1	0.4	0.8	0.3	0.9	-0.9	0.4
Impedance of leg (left)	0.2	1.1	3.6	-0.3	-0.2	1.9	-0.7
Leg predicted mass (left)	0.3	1.7	5.5	0.6	0.9	-2.3	-0.2
Trunk fat mass	0.1	0.4	1.0	0.2	0.7	-1.0	-0.6
Waist circumference	0.1	0.3	0.7	-0.3	0.9	-0.7	-0.2
Number of incorrect matches in round	0.2	0.3	1.1	0.4	0.1	-0.2	1.0
Past tobacco smoking	0.6	1.1	2.5	0.5	-0.2	-1.6	-1.2
Alcohol usually taken with meals	1.5	2.5	4.9	1.3	2.2	-1.8	-0.4
Nervous feelings	0.1	0.2	0.5	0.5	-0.3	0.2	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.4	-0.5	-0.6	-0.2
Hearing difficulty/problems with background noise	0.6	1.0	1.7	-1.0	1.1	-1.3	-0.1
Hair/balding pattern: Pattern 2	0.7	0.9	3.2	0.0	-0.4	-0.3	-1.8
Had menopause	1.4	1.8	4.9	-0.9	-2.2	1.0	0.4
Had other major operations	0.2	0.2	0.5	0.6	0.1	-0.7	-0.2
Forced vital capacity (FVC)	0.5	1.9	5.8	0.3	2.4	0.8	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.1	0.9	-0.2	-0.5	-1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.6	-0.7	-1.6	-0.4	-0.3
Qualifications: None of the above	0.2	0.4	1.1	-0.6	-1.1	-0.2	-0.4
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.8	-0.3	0.8	0.4
Mouth/teeth dental problems	0.4	0.7	1.4	-0.4	-1.2	-1.1	-0.2
Heart attack	0.2	0.3	1.2	0.1	-1.1	0.1	-0.1
Allergy	0.5	1.2	3.0	0.2	-0.7	1.1	1.7
Pain all over the body in last month	0.7	0.7	1.5	-1.2	-0.4	-1.1	0.1
Diabetes (self-reported)	0.1	0.2	0.5	-0.7	0.3	-0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.7	-0.9	1.9	1.6	1.3
Medication: Ramipril	0.6	0.8	1.8	0.3	-0.3	-1.4	-1.0
Medication: Simvastatin	0.9	1.3	2.7	1.7	1.5	-0.4	0.1
Fluid intelligence score	0.9	1.8	5.8	1.1	2.4	0.4	0.5
Illnesses of siblings	1.7	2.4	5.0	-0.4	1.8	2.2	1.2
Neuroticism score	0.4	0.8	1.3	-1.2	-1.0	0.8	-0.5
Weight	0.2	0.8	2.5	0.1	0.9	-1.6	-0.3
Impedance of arm (right)	0.6	2.6	4.9	-1.2	-1.2	2.2	-1.6
Arm fat percentage (right)	0.0	0.2	0.3	-0.3	0.5	0.0	-0.6
Trunk fat-free mass	0.2	1.3	3.8	0.4	1.1	-2.0	0.4
Hip circumference	0.2	1.1	3.5	-0.4	0.8	-1.9	0.0
Time employed in main current job	0.4	0.5	1.1	-0.3	1.0	-0.5	0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.5	-0.4	0.3	-1.2	0.4
Father’s age at death	0.6	0.8	2.5	-1.6	-0.5	-0.4	-0.4
Worrier / anxious feelings	0.3	0.6	1.7	0.3	-1.3	0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.7	-0.8	-0.8	0.0	-0.7
Falls in the last year	0.4	0.5	0.8	-0.8	-0.7	-0.4	0.9
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	0.2	-0.4	-1.3	-1.0
Number of live births	0.2	0.3	0.4	-0.6	0.5	0.6	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.3	0.7	2.3	0.3	1.4
Pulse rate	1.0	1.7	3.9	-0.8	1.1	2.0	1.0
Happiness	1.0	1.2	3.5	-1.9	-0.6	0.7	-0.6
Noisy workplace	0.3	0.4	1.4	-0.3	0.0	-1.2	0.0
Qualifications: A levels/AS levels or equivalent	0.9	1.9	6.1	0.1	-0.5	-1.2	-2.5
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	5.0	0.2	0.3	-1.3	-2.2
Mouth/teeth dental problems: Dentures	0.8	1.4	3.5	-0.7	0.2	1.3	1.9
Asthma	0.7	1.4	1.9	1.4	0.9	-1.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.3	-1.0	-1.1	0.1	0.4
Medication: Cholesterol lowering	1.0	1.6	4.6	2.2	1.3	0.2	-0.2
Depression (self-reported)	1.4	1.6	2.2	-0.2	-1.5	-1.4	-1.5
Medication: Lansoprazole	0.2	0.2	0.7	0.4	0.1	0.1	0.8
Prospective memory result	0.3	0.4	1.3	0.6	-1.1	-0.1	-0.2
Lung cancer (father)	1.1	1.3	3.8	0.6	0.3	-0.9	-2.0
Illnesses of mother	0.8	1.0	3.3	0.5	-1.8	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	4.0	1.0	2.0	-0.1	0.9
Pulse wave Arterial Stiffness index	1.0	1.2	2.4	-1.1	-0.8	1.6	0.9
Impedance of arm (left)	0.3	1.4	2.8	-0.7	-0.8	1.7	-1.3
Arm fat mass (right)	0.1	0.3	0.5	-0.2	0.6	-0.7	-0.3
Trunk predicted mass	0.2	1.4	4.1	0.4	1.0	-2.0	0.4
Standing height	0.1	1.0	2.3	-0.6	0.2	-1.5	-1.2
Length of working week for main job	1.6	1.7	2.7	1.6	1.2	0.4	1.6
Exposure to tobacco smoke at home	1.7	1.9	3.6	0.4	1.9	1.4	1.4
Breastfed as a baby	1.3	1.6	4.7	0.5	2.2	-0.6	1.1
Tense / ‘highly strung’	0.5	0.9	1.9	0.5	1.1	-0.2	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.2	-0.6	-1.8	-0.6	-1.6
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.6	-0.2	-0.7	-0.5
Birth weight of first child	0.3	0.6	1.8	-0.2	1.3	-0.7	0.4
Peak expiratory flow (PEF)	1.2	2.8	5.0	1.4	2.2	-1.0	1.7
Pulse wave reflection index	0.2	0.2	0.6	-0.5	-0.7	0.1	0.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.3	0.2	-0.3	-1.5	-1.4
Loud music exposure frequency	0.3	0.4	0.8	-0.3	0.1	0.9	0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.4	-0.4	-0.7	0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	0.9	-0.1	0.7	-1.4
Blood clot in the leg (DVT)	0.7	0.9	1.6	-0.6	-1.3	-1.2	-0.5
Medication: Paracetamol	0.0	0.1	0.2	-0.4	-0.1	-0.3	0.1
Headache pain in last month	0.3	0.6	1.4	1.2	0.2	-0.3	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.8	-1.9	-0.6	-0.6	-0.1
Glaucoma (self-reported)	0.4	0.5	1.0	0.6	-0.2	0.8	1.0
Gout (self-reported)	0.9	1.2	2.1	-0.2	1.3	1.4	1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.5	1.6	1.5	-0.2	-0.3
Medication: Amlodipine	0.0	0.1	0.2	0.4	0.1	0.0	-0.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.8	0.2	-0.3	0.2	-1.7
Birth weight	0.6	1.3	2.7	-0.8	-1.0	-1.6	-0.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	0.4	-0.4	-0.7	-0.9
High blood pressure (siblings)	1.0	1.4	3.3	1.6	0.2	-1.8	0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	3.1	0.6	1.8	0.1	0.6
Body fat percentage	0.1	0.2	0.4	-0.2	0.5	-0.4	-0.7
Leg fat percentage (right)	0.2	0.6	1.1	-0.5	0.9	-0.5	-1.1
Arm fat-free mass (right)	0.3	1.4	3.8	0.6	1.1	-1.9	0.5
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.3	-0.5	0.4	0.7
Comparative body size at age 10	1.0	2.8	3.9	1.6	2.0	1.5	1.6
Number of full brothers	1.2	1.5	2.5	1.2	1.4	-1.6	-0.4
Worry too long after embarrassment	0.8	1.4	3.0	-1.7	-1.2	0.8	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.2	-1.0	-1.5	-0.6	-0.3
Wheeze or whistling in the chest in last year	1.5	2.6	5.9	2.4	1.9	-0.8	-0.6
Number of children fathered	0.5	0.6	1.8	0.3	-0.0	-0.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	2.7	-1.4	-1.6	0.4	1.2
Age at first live birth	0.4	0.7	1.4	1.2	1.1	0.2	0.5
Pulse wave peak to peak time	0.9	1.1	2.4	0.8	0.7	-1.6	-0.8
Health satisfaction	0.8	1.1	2.0	-0.1	1.0	1.4	1.1
Shortness of breath walking on level ground	0.4	0.5	1.1	-0.9	0.1	0.0	1.1
Qualifications: College or University degree	0.4	1.1	2.5	-1.2	-1.6	0.7	-0.4
Eye problems/disorders: None of the above	0.7	0.8	2.7	-0.3	-0.4	-1.6	-0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.4	0.8	0.3	-0.5
Emphysema/chronic bronchitis	0.6	0.7	1.5	1.2	0.2	-0.4	-1.0
Medication for pain relief, constipation, heartburn	0.4	0.6	1.7	0.3	0.8	1.3	-0.3
Neck or shoulder pain in last month	0.9	1.2	1.9	1.4	0.9	-1.3	-0.7
Medication: Blood pressure	0.2	0.3	0.8	0.9	-0.1	0.5	0.4
Angina (self-reported)	0.5	0.7	1.4	1.2	0.6	-0.3	-1.0
Migraine (self-reported)	0.1	0.1	0.3	-0.3	-0.0	0.3	-0.6
Medication: Ibuprofen	0.6	0.8	1.5	-1.1	-1.2	0.2	0.4
Medication: Allopurinol	0.6	0.7	2.6	-0.6	0.1	1.6	-0.1
Medication: Omeprazole	0.5	0.6	1.4	-1.2	-0.8	0.5	0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.2	0.7	0.5	0.1
Mean time to correctly identify matches	0.8	1.5	3.1	-1.0	-1.8	-1.3	-0.4
Heart disease (mother)	0.1	0.2	0.3	-0.6	0.3	0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.1	1.0	-0.8	-0.6
Whole body fat mass	0.1	0.4	1.0	-0.1	0.5	-1.0	-0.5
Leg fat mass (right)	0.2	0.9	1.5	0.1	1.2	-1.2	-0.6
Arm predicted mass (right)	0.3	1.3	4.0	0.6	0.9	-2.0	0.3
Pulse rate, automated reading	0.5	1.5	3.6	-0.5	1.4	1.9	0.4
Alcohol intake frequency.	0.4	1.0	3.5	-0.6	0.2	-1.9	-0.1
Comparative height size at age 10	0.1	0.4	1.4	-1.2	-0.2	0.0	-0.3
Number of full sisters	2.1	2.5	5.1	-1.0	-0.7	-1.8	-2.3
Suffer from ‘nerves’	0.3	0.5	1.0	-0.6	-0.9	-0.0	1.0
Overall health rating	0.4	0.8	2.1	0.9	1.4	-0.4	-0.4
Chest pain or discomfort	2.4	3.5	7.1	2.2	2.7	-0.7	-1.3
Had major operations	0.7	0.8	1.9	1.4	-0.1	0.7	-1.0
Age at last live birth	0.5	0.7	2.1	1.5	0.7	0.1	0.3
Family relationship satisfaction	0.9	1.2	2.7	-1.3	0.3	0.4	-1.6
Leg pain on walking	0.2	0.3	0.9	-0.1	0.4	-0.9	-0.1
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.3	6.8	2.6	1.4	-1.4	-1.5
Commuting to job workplace: Car/motor vehicle	1.9	2.2	3.9	0.4	1.6	1.4	2.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	0.2	-1.1	-0.1	0.4
Medication: Aspirin	0.3	0.5	1.1	0.6	-0.5	-1.0	-0.3
Supplements: Vitamin C	0.7	0.9	2.4	0.5	0.4	0.8	1.6
Knee pain experienced in last month	0.8	1.3	2.8	1.0	0.2	-1.7	-1.1
Hypertension (Self-reported)	0.3	0.8	1.3	1.2	-1.1	0.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.8	1.1	1.7	-0.3	0.6
Illnesses of father: Heart disease	0.5	0.7	1.2	0.9	-0.6	-0.5	-1.1
Illnesses of siblings: Diabetes	0.8	1.0	1.8	-0.8	-1.4	-1.1	-0.6
Smoking status: Previous	0.6	0.8	2.0	-0.4	-0.2	1.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	5.6	1.7	2.4	-0.9	-0.3
Whole body fat-free mass	0.3	1.6	5.1	0.5	1.0	-2.3	0.2
Leg fat-free mass (right)	0.3	1.7	5.5	0.7	0.8	-2.4	0.1
Arm fat percentage (left)	0.0	0.1	0.4	-0.1	0.6	0.1	-0.3
Average weekly red wine intake	0.3	0.4	1.3	-0.5	0.2	-1.2	-0.2
Handedness (chirality/laterality): Left-handed	2.4	2.9	5.4	-2.0	-0.5	2.3	1.4
Mood swings	0.5	0.9	2.5	0.7	-0.1	-1.6	-0.7
Loneliness, isolation	0.7	0.9	2.8	-0.9	0.0	1.7	-0.1
Long-standing illness, disability or infirmity	0.9	1.3	2.9	1.3	1.7	-0.8	-0.1
Ever had bowel cancer screening	1.3	1.5	4.7	0.3	-0.6	-0.9	-2.2
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.1	0.6	-0.4	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.3	1.5	-0.2	-0.9	-0.9
Friendships satisfaction	0.6	0.7	1.7	-0.3	0.9	0.6	-1.3
Qualifications: nursing, teaching	0.0	0.0	0.1	0.0	0.2	0.0	-0.3
Commuting to job workplace: Walk	2.8	3.0	6.5	-0.4	-2.3	-0.2	-2.6
Eye problems/disorders: Cataract	0.5	0.5	1.7	0.6	-0.0	1.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.7	1.3	0.8	-1.9	-0.6
Medication for cholesterol	0.1	0.2	0.6	-0.4	0.8	0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	0.4	1.1	0.7	0.6
Back pain experienced in last month	0.3	0.4	0.7	0.8	0.6	-0.5	0.4
Mineral and other dietary supplements	2.2	3.0	5.9	0.9	1.4	-2.4	-1.8
Breast cancer (self-reported)	1.1	1.3	3.6	1.0	1.9	-0.1	0.7
Asthma (self-reported)	0.8	1.6	2.4	1.5	1.3	-1.3	-0.9
Osteoporosis (self-reported)	1.3	1.7	2.8	-1.3	-0.5	1.7	1.4
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.8	-0.2	-0.7	0.3
Medication: Aspirin	0.3	0.4	0.6	0.7	-0.6	-0.8	-0.4
Medication: Gliclazide	1.6	1.9	4.1	0.6	-0.4	-2.0	-1.7
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	0.5	1.1	0.1	0.8
Smoking status: Current	0.2	0.3	0.9	-1.0	0.6	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.7	-0.7	0.9	1.9	0.4
Whole body water mass	0.3	1.6	4.9	0.6	1.1	-2.2	0.2
Leg predicted mass (right)	0.3	1.7	5.5	0.8	0.9	-2.3	0.1
Arm fat mass (left)	0.1	0.2	0.5	-0.2	0.7	-0.6	-0.2
Number of self-reported non-cancer illnesses	0.4	0.7	1.2	1.1	0.3	-0.9	-0.9
Average weekly champagne plus white wine intake	2.0	2.7	5.8	-0.1	-2.4	-1.0	-2.0
Miserableness	0.8	1.3	3.7	0.2	-1.1	-0.6	-1.9
Guilty feelings	1.8	2.7	6.6	-1.8	-2.6	1.0	-0.2
Wears glasses or contact lenses	1.4	1.6	3.7	1.4	0.4	1.9	0.7
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.4	0.8	-0.2	-0.1
Hearing aid user	1.4	1.5	2.4	-1.6	-1.1	-1.4	0.7
Mother’s age at death	1.1	1.3	1.7	-1.2	1.3	1.1	1.0
Financial situation satisfaction	0.2	0.2	0.8	-0.2	-0.1	0.9	0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.7	-0.6	0.2	-1.3	-0.1
Commuting to job workplace: Public transport	0.7	0.8	1.7	-0.4	-1.2	-0.2	-1.3
Eye problems/disorders: Glaucoma	0.6	0.7	2.4	-0.2	-0.5	1.5	0.5
Medication: Blood pressure	0.2	0.3	0.8	0.2	-0.9	-0.7	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	-0.5	-0.3	-1.0	0.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.2	-0.6	-1.0	0.4	1.5
High cholesterol (Self-reported)	0.6	1.1	1.9	1.2	1.4	-0.6	0.8
Medication: Bendroflumethiazide	0.7	1.0	1.6	0.2	-1.2	-0.9	-1.3
Medication: Paracetamol	0.4	0.6	0.8	-0.9	-0.9	-0.8	-0.4
Medication: Lisinopril	0.7	0.9	1.5	1.0	0.4	1.0	1.2
Medication: Atorvastatin	0.7	0.9	2.5	0.9	0.1	0.5	1.6
Illnesses of father: High blood pressure	1.7	2.1	3.3	-1.8	-1.8	1.3	-0.7
Alcohol drinker status: Never	0.9	1.1	2.8	-0.9	-1.7	-0.2	0.8
Ever smoked	0.4	0.7	1.6	-0.5	0.6	1.2	0.7
Basal metabolic rate	0.3	1.5	4.6	0.5	1.1	-2.1	0.1
Leg fat percentage (left)	0.1	0.4	0.8	-0.1	0.9	-0.6	-0.7
Arm fat-free mass (left)	0.2	1.1	3.5	0.2	0.9	-1.9	0.2
Number of operations (self-reported)	0.6	0.8	2.4	0.4	-0.2	-0.9	-1.5
Average weekly beer plus cider intake	0.2	0.3	0.7	0.0	0.8	-0.3	0.6
Irritability	0.5	0.9	1.0	1.0	0.9	1.0	0.9
Risk taking	0.1	0.2	0.6	0.3	0.2	-0.8	-0.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.8	1.4	-0.8	-1.1	-0.6
Fractured/broken bones in last 5 years	0.5	0.6	1.7	-0.3	-0.1	1.3	-0.9
Age started oral contraceptive pill	1.2	1.5	2.8	-1.1	-1.7	0.9	1.0
Diastolic blood pressure, automated reading	0.5	1.7	4.9	-1.1	-0.8	2.2	0.2
Ever depressed for a whole week	1.2	1.4	4.8	0.1	-0.6	-0.7	-2.2
Unable to work because of sickness or disability	0.7	0.8	1.6	-1.3	-0.3	-0.5	-1.2
Commuting to job workplace: Cycle	0.6	0.7	2.6	0.5	0.1	-1.6	-0.2
Myopia	0.6	0.9	2.2	0.8	-0.7	-0.2	-1.5
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.5	-1.9	0.4	0.3	0.7
Cholesterol lowering medication	0.5	0.7	1.5	-0.8	0.7	0.1	1.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.2	-1.5	-0.4	0.4	1.0
Pain experienced in last month	0.8	1.3	4.2	-0.6	0.5	2.0	0.6
Supplements: Calcium	1.3	1.4	3.1	-0.9	-1.1	1.8	0.8
Basal cell carcinoma (self-reported)	0.6	0.8	1.7	0.4	1.1	-0.1	1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.3	-1.0	0.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	-0.4	-0.9	-1.2	-0.3
Heart disease (siblings)	0.6	0.8	1.2	0.8	-1.1	-0.6	-1.0
Alcohol drinker status: Previous	1.8	2.0	4.1	0.1	0.2	-2.0	-2.0
Pack years of smoking	0.3	0.4	1.4	0.3	0.3	-1.2	-0.5
Impedance of whole body	0.4	2.1	4.4	-0.9	-1.0	2.1	-1.6
Leg fat mass (left)	0.2	0.7	1.3	0.2	1.1	-1.1	-0.3
Arm predicted mass (left)	0.2	1.0	3.3	0.0	0.7	-1.8	0.1