Hub : Genes

CECR5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1550 0.0440 0.00050 0.019 NA 0.039 NA 0.036 1.0e-02 NA 3.4e-04 NA 6.0e-04
2 METSIM Adipose 0.0926 0.0258 0.00012 0.051 0.038 0.062 0.039 0.060 3.7e-08 1.7e-06 1.1e-09 1.3e-06 2.2e-09
3 TCGA Colon Adenocarcinoma 0.1450 0.0600 0.00160 0.073 0.019 0.096 NA 0.070 4.9e-05 2.8e-02 3.6e-06 NA 7.0e-05
4 TCGA Pancreatic Adenocarcinoma 0.2540 0.0940 0.00051 0.004 0.085 0.058 NA -0.004 2.0e-01 2.0e-04 2.0e-03 NA 5.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.7 1.1 2.8 -1.2 -0.2 0.0 -1.7
Bipolar Disorder or Schizophrenia 0.8 1.9 5.0 0.1 0.5 -1.6 -2.2
Depressed Affect (Nagel 2018) 0.7 1.6 4.2 -0.9 -0.8 -0.8 -2.0
Depression (Nagel 2018) 1.4 2.2 3.7 -1.2 -1.7 -0.8 -1.9
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.2 0.4 1.1 0.5 -0.1
Neuroticism (Nagel 2018) 0.6 1.3 2.8 -1.1 -1.0 0.5 -1.7
Schizophrenia (2018) 0.5 1.0 2.0 1.1 0.8 0.0 -1.4
Schizophrenia vs Biploar Disorder 1.1 1.4 5.5 0.5 2.4 0.0 -0.1
Worry (Nagel 2018) 0.3 0.6 1.5 -1.2 -0.7 0.3 -0.5
Alzheimer’s Disease (in mother) 0.3 0.4 1.0 -0.3 1.0 -0.6 -0.4
Alzheimer’s Disease (in father) 0.3 0.3 1.0 0.0 0.4 -0.1 1.0
Alzheimer’s Disease (including proxy) 0.3 0.4 0.9 -0.3 1.0 -0.4 0.6
Crohns Disease (2017) 0.0 0.0 0.1 0.1 -0.0 0.3 -0.1
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 0.0 -0.3 0.5 -0.6
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.5 -0.2 0.3 -0.6
Major Depression (MDD) 1.6 1.9 4.7 2.2 1.7 0.0 -0.1
Reaction Time 0.1 0.2 0.4 -0.4 -0.6 -0.6 0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.3 3.3 1.0 1.8 0.8 0.5
Breast Cancer 0.1 0.3 0.5 0.4 0.6 0.7 -0.3
Ovarian Cancer 0.2 0.3 0.7 0.4 0.9 0.5 0.3
Prostate Cancer 0.1 0.1 0.2 -0.3 -0.1 0.0 -0.4
Age at First Birth 0.2 0.3 0.5 0.6 0.7 -0.3 -0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 -0.9 0.7 0.2 1.2
Coronary Artery Disease (CAD) 0.5 0.6 2.2 0.6 0.1 0.0 1.5
Crohns Disease (2012) 0.2 0.3 0.7 -0.8 0.6 0.0 -0.4
Mean Putamen Volume 3.7 4.2 8.2 2.3 2.9 -0.2 1.9
Fasting Glucose 0.1 0.1 0.2 -0.2 0.4 0.5 0.2
HbA1C 0.5 0.6 1.1 0.8 0.0 1.1 -0.8
HDL Cholesterol 0.8 1.3 3.1 -0.2 -0.0 1.5 1.8
LDL Cholesterol 0.8 1.3 1.8 1.4 1.1 -1.2 -0.8
Lupus 1.7 2.6 6.4 -0.8 -2.5 1.4 -1.3
Neuroticism (2016) 0.3 0.4 0.8 -0.2 -0.8 -0.3 -0.9
Primary Biliary Cirrhosis 0.5 0.7 2.6 0.6 0.2 1.6 0.1
Rheumatoid Arthritis 1.0 1.4 2.5 -0.8 -0.4 1.6 1.6
Schizophrenia (2014) 0.5 1.1 2.5 0.8 1.6 0.0 -1.1
Triglycerides 1.2 2.0 5.7 2.4 1.4 -0.5 -0.2
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.2 -0.9 -0.3 0.0 1.1
Ulcerative Colitis 0.2 0.4 1.1 -1.1 -0.5 0.0 0.1
Blood Eosinophil Count 0.5 3.7 7.7 0.2 2.4 -1.2 -2.8
Blood Platelet Count 0.1 1.3 3.1 1.5 -0.0 -0.1 -1.8
Blood Red Count 0.1 1.2 3.2 -0.2 1.1 -0.5 -1.8
Blood White Count 1.1 7.9 26.8 -1.5 1.2 -1.0 -5.2
Heel T-Score 0.1 0.8 2.5 1.6 0.5 -0.4 -0.6
BMI 0.1 0.6 0.9 0.9 0.8 -0.9 -0.4
Height 0.1 2.6 7.9 -0.9 -0.4 -2.8 -1.1
Waist Hip Ratio (WHR) 0.3 1.4 1.8 1.1 1.3 1.3 -0.9
Systolic Blood Pressure 0.4 1.9 5.3 -0.4 -0.4 1.5 2.3
Smoking Status 0.3 0.7 2.0 -0.6 0.6 1.4 -0.0
Allergy or Eczema 0.5 1.4 5.1 -0.2 0.2 -0.6 -2.3
Cardiovascular Disease 0.1 0.3 1.1 1.1 0.5 -0.1 0.1
Hypothyroidism (self reported) 0.6 1.3 2.4 1.0 1.6 -0.8 -1.0
Respiratory disease 0.2 0.5 0.9 0.7 0.9 -0.4 -0.6
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.1 0.7 1.4 -0.2 0.2
Lung FEV1/FVC ratio 0.4 1.9 3.3 1.2 1.8 -0.7 1.6
Lung FVC 0.3 1.4 4.1 -1.0 0.2 2.0 0.6
Neuroticism 0.5 1.3 3.2 -1.8 -1.1 0.7 -0.7
Chronotype (morning person) 1.3 3.0 7.6 -0.9 -0.0 -2.8 -1.9
Hair Pigment 0.0 0.6 1.6 0.4 0.8 -1.3 0.3
Tanning 0.2 2.0 4.0 0.4 -2.0 -1.3 -1.5
Hand grip strength (left) 0.8 2.2 4.2 1.5 2.0 -1.5 -0.0
Number of treatments/medications taken 0.1 0.2 0.3 -0.1 -0.5 -0.3 -0.5
Average weekly spirits intake 0.6 0.7 1.6 0.2 -0.7 1.3 0.7
Sensitivity / hurt feelings 0.4 0.7 2.2 -0.3 -0.4 0.6 -1.5
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.6 -0.4 -1.3 -0.4 -1.3
Hearing difficulty/problems: Yes 3.0 4.6 9.4 -1.9 -1.8 -3.1 -1.5
Relative age of first facial hair 0.5 1.0 2.2 -0.1 -1.3 0.0 -1.5
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.7 -0.5 0.6 0.8 0.7
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.5 -0.4 -1.2 0.6 -0.4
Ever had hysterectomy (womb removed) 0.7 0.8 1.5 -0.8 -1.2 0.8 -0.6
Systolic blood pressure, automated reading 0.8 2.4 4.7 -1.4 -1.4 2.2 0.9
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.4 1.1 1.3 -1.5 -0.2
Angina 0.6 0.8 1.4 1.2 0.7 -0.5 -1.0
Medication for hormone replacement therapy 0.4 0.5 0.7 0.5 -0.9 -0.6 -0.7
Vitamin and mineral supplements 0.7 0.9 1.7 0.3 0.6 -1.3 -1.3
Supplements: Zinc 0.3 0.3 0.7 0.2 0.5 0.8 -0.7
Medication: Co-codamol 0.3 0.3 0.8 0.4 -0.4 -0.9 -0.3
Medication: Metformin 0.6 0.8 2.4 -0.2 0.6 -0.6 -1.6
Diabetes (father) 0.1 0.1 0.2 -0.4 0.3 -0.2 -0.1
Diabetes (mother) 2.1 2.6 4.8 2.2 2.1 -0.3 1.1
Severe depression (siblings) 1.4 1.6 3.5 -0.4 -0.4 -1.9 -1.6
Pack years adult smoking proportion 0.4 0.7 1.4 0.7 0.7 -1.2 -0.4
Impedance of leg (right) 0.3 1.4 3.8 -0.6 -0.2 1.9 -1.2
Leg fat-free mass (left) 0.3 1.8 5.6 0.7 1.0 -2.4 -0.3
Trunk fat percentage 0.0 0.2 0.5 -0.0 0.4 -0.4 -0.7
Hand grip strength (right) 1.2 3.4 6.1 1.9 1.9 -2.5 -0.5
Townsend deprivation index at recruitment 0.4 0.6 1.0 -0.8 -0.4 0.8 1.0
Current tobacco smoking 0.3 0.5 1.3 -1.1 0.0 -0.0 -0.8
Average weekly fortified wine intake 0.4 0.5 0.8 -0.6 -0.9 0.1 0.8
Maternal smoking around birth 0.3 0.4 1.0 0.7 0.0 -1.0 -0.4
Fed-up feelings 0.1 0.2 0.8 -0.3 -0.1 0.1 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 3.5 0.2 -1.4 -1.2 -1.9
Relative age voice broke 0.6 0.9 1.7 -0.7 -0.9 1.3 -0.8
Taking other prescription medications 0.2 0.3 0.6 0.8 0.3 -0.1 -0.8
Age when periods started (menarche) 0.2 0.5 0.8 -0.9 -0.3 -0.9 -0.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.4 0.3 -0.9 0.5 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.3 0.2 0.4 -0.5 -0.4
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.1 -0.2 1.5 0.5 0.5
Qualifications: CSEs or equivalent 0.9 1.2 1.9 1.2 1.4 1.0 0.6
Serious illness, injury or assault to yourself 0.4 0.5 1.0 0.5 1.0 0.5 -0.6
High blood pressure 0.4 1.0 3.3 1.8 -0.7 0.4 -0.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.5 -0.8 0.7 -0.5 -1.2
Multivitamins +/- minerals 0.3 0.4 0.9 -0.5 0.0 0.7 0.9
Stomach or abdominal pain in last month 0.3 0.3 0.7 0.4 -0.1 0.8 -0.6
Supplements: Glucosamine 0.3 0.4 0.8 -0.2 -0.1 0.9 0.9
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 0.5 0.6 -1.3 -0.4
Medication: Atenolol 0.5 0.7 2.1 -0.1 -0.2 -1.5 0.6
Medication: Levothyroxine sodium 0.5 0.8 1.4 0.9 0.8 -0.6 -1.2
Sitting height 0.1 0.5 1.9 -0.1 -0.1 -1.4 -0.2
Chronic bronchitis/emphysema (father) 0.3 0.4 1.2 -1.1 -0.0 -0.5 -0.3
High blood pressure (mother) 0.5 0.6 2.0 0.1 1.4 -0.6 0.4
Body mass index (BMI) 0.1 0.4 0.8 0.3 0.9 -0.9 0.4
Impedance of leg (left) 0.2 1.1 3.6 -0.3 -0.2 1.9 -0.7
Leg predicted mass (left) 0.3 1.7 5.5 0.6 0.9 -2.3 -0.2
Trunk fat mass 0.1 0.4 1.0 0.2 0.7 -1.0 -0.6
Waist circumference 0.1 0.3 0.7 -0.3 0.9 -0.7 -0.2
Number of incorrect matches in round 0.2 0.3 1.1 0.4 0.1 -0.2 1.0
Past tobacco smoking 0.6 1.1 2.5 0.5 -0.2 -1.6 -1.2
Alcohol usually taken with meals 1.5 2.5 4.9 1.3 2.2 -1.8 -0.4
Nervous feelings 0.1 0.2 0.5 0.5 -0.3 0.2 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.4 0.4 -0.5 -0.6 -0.2
Hearing difficulty/problems with background noise 0.6 1.0 1.7 -1.0 1.1 -1.3 -0.1
Hair/balding pattern: Pattern 2 0.7 0.9 3.2 0.0 -0.4 -0.3 -1.8
Had menopause 1.4 1.8 4.9 -0.9 -2.2 1.0 0.4
Had other major operations 0.2 0.2 0.5 0.6 0.1 -0.7 -0.2
Forced vital capacity (FVC) 0.5 1.9 5.8 0.3 2.4 0.8 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.6 1.1 0.9 -0.2 -0.5 -1.0
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.6 -0.7 -1.6 -0.4 -0.3
Qualifications: None of the above 0.2 0.4 1.1 -0.6 -1.1 -0.2 -0.4
Financial difficulties in last 2 years 0.3 0.4 0.7 -0.8 -0.3 0.8 0.4
Mouth/teeth dental problems 0.4 0.7 1.4 -0.4 -1.2 -1.1 -0.2
Heart attack 0.2 0.3 1.2 0.1 -1.1 0.1 -0.1
Allergy 0.5 1.2 3.0 0.2 -0.7 1.1 1.7
Pain all over the body in last month 0.7 0.7 1.5 -1.2 -0.4 -1.1 0.1
Diabetes (self-reported) 0.1 0.2 0.5 -0.7 0.3 -0.2 -0.4
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.7 -0.9 1.9 1.6 1.3
Medication: Ramipril 0.6 0.8 1.8 0.3 -0.3 -1.4 -1.0
Medication: Simvastatin 0.9 1.3 2.7 1.7 1.5 -0.4 0.1
Fluid intelligence score 0.9 1.8 5.8 1.1 2.4 0.4 0.5
Illnesses of siblings 1.7 2.4 5.0 -0.4 1.8 2.2 1.2
Neuroticism score 0.4 0.8 1.3 -1.2 -1.0 0.8 -0.5
Weight 0.2 0.8 2.5 0.1 0.9 -1.6 -0.3
Impedance of arm (right) 0.6 2.6 4.9 -1.2 -1.2 2.2 -1.6
Arm fat percentage (right) 0.0 0.2 0.3 -0.3 0.5 0.0 -0.6
Trunk fat-free mass 0.2 1.3 3.8 0.4 1.1 -2.0 0.4
Hip circumference 0.2 1.1 3.5 -0.4 0.8 -1.9 0.0
Time employed in main current job 0.4 0.5 1.1 -0.3 1.0 -0.5 0.8
Alcohol intake versus 10 years previously 0.3 0.5 1.5 -0.4 0.3 -1.2 0.4
Father’s age at death 0.6 0.8 2.5 -1.6 -0.5 -0.4 -0.4
Worrier / anxious feelings 0.3 0.6 1.7 0.3 -1.3 0.6 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.7 -0.8 -0.8 0.0 -0.7
Falls in the last year 0.4 0.5 0.8 -0.8 -0.7 -0.4 0.9
Hair/balding pattern: Pattern 3 0.5 0.7 1.8 0.2 -0.4 -1.3 -1.0
Number of live births 0.2 0.3 0.4 -0.6 0.5 0.6 -0.1
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 5.3 0.7 2.3 0.3 1.4
Pulse rate 1.0 1.7 3.9 -0.8 1.1 2.0 1.0
Happiness 1.0 1.2 3.5 -1.9 -0.6 0.7 -0.6
Noisy workplace 0.3 0.4 1.4 -0.3 0.0 -1.2 0.0
Qualifications: A levels/AS levels or equivalent 0.9 1.9 6.1 0.1 -0.5 -1.2 -2.5
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 5.0 0.2 0.3 -1.3 -2.2
Mouth/teeth dental problems: Dentures 0.8 1.4 3.5 -0.7 0.2 1.3 1.9
Asthma 0.7 1.4 1.9 1.4 0.9 -1.2 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.3 -1.0 -1.1 0.1 0.4
Medication: Cholesterol lowering 1.0 1.6 4.6 2.2 1.3 0.2 -0.2
Depression (self-reported) 1.4 1.6 2.2 -0.2 -1.5 -1.4 -1.5
Medication: Lansoprazole 0.2 0.2 0.7 0.4 0.1 0.1 0.8
Prospective memory result 0.3 0.4 1.3 0.6 -1.1 -0.1 -0.2
Lung cancer (father) 1.1 1.3 3.8 0.6 0.3 -0.9 -2.0
Illnesses of mother 0.8 1.0 3.3 0.5 -1.8 0.4 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 4.0 1.0 2.0 -0.1 0.9
Pulse wave Arterial Stiffness index 1.0 1.2 2.4 -1.1 -0.8 1.6 0.9
Impedance of arm (left) 0.3 1.4 2.8 -0.7 -0.8 1.7 -1.3
Arm fat mass (right) 0.1 0.3 0.5 -0.2 0.6 -0.7 -0.3
Trunk predicted mass 0.2 1.4 4.1 0.4 1.0 -2.0 0.4
Standing height 0.1 1.0 2.3 -0.6 0.2 -1.5 -1.2
Length of working week for main job 1.6 1.7 2.7 1.6 1.2 0.4 1.6
Exposure to tobacco smoke at home 1.7 1.9 3.6 0.4 1.9 1.4 1.4
Breastfed as a baby 1.3 1.6 4.7 0.5 2.2 -0.6 1.1
Tense / ‘highly strung’ 0.5 0.9 1.9 0.5 1.1 -0.2 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 3.2 -0.6 -1.8 -0.6 -1.6
Hair/balding pattern: Pattern 4 0.1 0.3 0.5 0.6 -0.2 -0.7 -0.5
Birth weight of first child 0.3 0.6 1.8 -0.2 1.3 -0.7 0.4
Peak expiratory flow (PEF) 1.2 2.8 5.0 1.4 2.2 -1.0 1.7
Pulse wave reflection index 0.2 0.2 0.6 -0.5 -0.7 0.1 0.3
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.3 0.2 -0.3 -1.5 -1.4
Loud music exposure frequency 0.3 0.4 0.8 -0.3 0.1 0.9 0.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.5 0.4 -0.4 -0.7 0.1
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.8 0.9 -0.1 0.7 -1.4
Blood clot in the leg (DVT) 0.7 0.9 1.6 -0.6 -1.3 -1.2 -0.5
Medication: Paracetamol 0.0 0.1 0.2 -0.4 -0.1 -0.3 0.1
Headache pain in last month 0.3 0.6 1.4 1.2 0.2 -0.3 -0.9
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 3.8 -1.9 -0.6 -0.6 -0.1
Glaucoma (self-reported) 0.4 0.5 1.0 0.6 -0.2 0.8 1.0
Gout (self-reported) 0.9 1.2 2.1 -0.2 1.3 1.4 1.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.5 1.6 1.5 -0.2 -0.3
Medication: Amlodipine 0.0 0.1 0.2 0.4 0.1 0.0 -0.2
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.8 0.2 -0.3 0.2 -1.7
Birth weight 0.6 1.3 2.7 -0.8 -1.0 -1.6 -0.9
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 0.4 -0.4 -0.7 -0.9
High blood pressure (siblings) 1.0 1.4 3.3 1.6 0.2 -1.8 0.2
Forced vital capacity (FVC), Best measure 0.3 1.0 3.1 0.6 1.8 0.1 0.6
Body fat percentage 0.1 0.2 0.4 -0.2 0.5 -0.4 -0.7
Leg fat percentage (right) 0.2 0.6 1.1 -0.5 0.9 -0.5 -1.1
Arm fat-free mass (right) 0.3 1.4 3.8 0.6 1.1 -1.9 0.5
Exposure to tobacco smoke outside home 0.2 0.2 0.5 -0.3 -0.5 0.4 0.7
Comparative body size at age 10 1.0 2.8 3.9 1.6 2.0 1.5 1.6
Number of full brothers 1.2 1.5 2.5 1.2 1.4 -1.6 -0.4
Worry too long after embarrassment 0.8 1.4 3.0 -1.7 -1.2 0.8 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.2 -1.0 -1.5 -0.6 -0.3
Wheeze or whistling in the chest in last year 1.5 2.6 5.9 2.4 1.9 -0.8 -0.6
Number of children fathered 0.5 0.6 1.8 0.3 -0.0 -0.6 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 2.7 -1.4 -1.6 0.4 1.2
Age at first live birth 0.4 0.7 1.4 1.2 1.1 0.2 0.5
Pulse wave peak to peak time 0.9 1.1 2.4 0.8 0.7 -1.6 -0.8
Health satisfaction 0.8 1.1 2.0 -0.1 1.0 1.4 1.1
Shortness of breath walking on level ground 0.4 0.5 1.1 -0.9 0.1 0.0 1.1
Qualifications: College or University degree 0.4 1.1 2.5 -1.2 -1.6 0.7 -0.4
Eye problems/disorders: None of the above 0.7 0.8 2.7 -0.3 -0.4 -1.6 -0.6
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.6 0.4 0.8 0.3 -0.5
Emphysema/chronic bronchitis 0.6 0.7 1.5 1.2 0.2 -0.4 -1.0
Medication for pain relief, constipation, heartburn 0.4 0.6 1.7 0.3 0.8 1.3 -0.3
Neck or shoulder pain in last month 0.9 1.2 1.9 1.4 0.9 -1.3 -0.7
Medication: Blood pressure 0.2 0.3 0.8 0.9 -0.1 0.5 0.4
Angina (self-reported) 0.5 0.7 1.4 1.2 0.6 -0.3 -1.0
Migraine (self-reported) 0.1 0.1 0.3 -0.3 -0.0 0.3 -0.6
Medication: Ibuprofen 0.6 0.8 1.5 -1.1 -1.2 0.2 0.4
Medication: Allopurinol 0.6 0.7 2.6 -0.6 0.1 1.6 -0.1
Medication: Omeprazole 0.5 0.6 1.4 -1.2 -0.8 0.5 0.2
Medication: Seretide 50 evohaler 0.2 0.2 0.4 -0.2 0.7 0.5 0.1
Mean time to correctly identify matches 0.8 1.5 3.1 -1.0 -1.8 -1.3 -0.4
Heart disease (mother) 0.1 0.2 0.3 -0.6 0.3 0.2 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.0 -0.1 1.0 -0.8 -0.6
Whole body fat mass 0.1 0.4 1.0 -0.1 0.5 -1.0 -0.5
Leg fat mass (right) 0.2 0.9 1.5 0.1 1.2 -1.2 -0.6
Arm predicted mass (right) 0.3 1.3 4.0 0.6 0.9 -2.0 0.3
Pulse rate, automated reading 0.5 1.5 3.6 -0.5 1.4 1.9 0.4
Alcohol intake frequency. 0.4 1.0 3.5 -0.6 0.2 -1.9 -0.1
Comparative height size at age 10 0.1 0.4 1.4 -1.2 -0.2 0.0 -0.3
Number of full sisters 2.1 2.5 5.1 -1.0 -0.7 -1.8 -2.3
Suffer from ‘nerves’ 0.3 0.5 1.0 -0.6 -0.9 -0.0 1.0
Overall health rating 0.4 0.8 2.1 0.9 1.4 -0.4 -0.4
Chest pain or discomfort 2.4 3.5 7.1 2.2 2.7 -0.7 -1.3
Had major operations 0.7 0.8 1.9 1.4 -0.1 0.7 -1.0
Age at last live birth 0.5 0.7 2.1 1.5 0.7 0.1 0.3
Family relationship satisfaction 0.9 1.2 2.7 -1.3 0.3 0.4 -1.6
Leg pain on walking 0.2 0.3 0.9 -0.1 0.4 -0.9 -0.1
Qualifications: NVQ or HND or HNC or equivalent 2.7 3.3 6.8 2.6 1.4 -1.4 -1.5
Commuting to job workplace: Car/motor vehicle 1.9 2.2 3.9 0.4 1.6 1.4 2.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.1 0.2 -1.1 -0.1 0.4
Medication: Aspirin 0.3 0.5 1.1 0.6 -0.5 -1.0 -0.3
Supplements: Vitamin C 0.7 0.9 2.4 0.5 0.4 0.8 1.6
Knee pain experienced in last month 0.8 1.3 2.8 1.0 0.2 -1.7 -1.1
Hypertension (Self-reported) 0.3 0.8 1.3 1.2 -1.1 0.6 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.8 1.1 1.7 -0.3 0.6
Illnesses of father: Heart disease 0.5 0.7 1.2 0.9 -0.6 -0.5 -1.1
Illnesses of siblings: Diabetes 0.8 1.0 1.8 -0.8 -1.4 -1.1 -0.6
Smoking status: Previous 0.6 0.8 2.0 -0.4 -0.2 1.4 1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 5.6 1.7 2.4 -0.9 -0.3
Whole body fat-free mass 0.3 1.6 5.1 0.5 1.0 -2.3 0.2
Leg fat-free mass (right) 0.3 1.7 5.5 0.7 0.8 -2.4 0.1
Arm fat percentage (left) 0.0 0.1 0.4 -0.1 0.6 0.1 -0.3
Average weekly red wine intake 0.3 0.4 1.3 -0.5 0.2 -1.2 -0.2
Handedness (chirality/laterality): Left-handed 2.4 2.9 5.4 -2.0 -0.5 2.3 1.4
Mood swings 0.5 0.9 2.5 0.7 -0.1 -1.6 -0.7
Loneliness, isolation 0.7 0.9 2.8 -0.9 0.0 1.7 -0.1
Long-standing illness, disability or infirmity 0.9 1.3 2.9 1.3 1.7 -0.8 -0.1
Ever had bowel cancer screening 1.3 1.5 4.7 0.3 -0.6 -0.9 -2.2
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.1 0.6 -0.4 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.3 1.5 -0.2 -0.9 -0.9
Friendships satisfaction 0.6 0.7 1.7 -0.3 0.9 0.6 -1.3
Qualifications: nursing, teaching 0.0 0.0 0.1 0.0 0.2 0.0 -0.3
Commuting to job workplace: Walk 2.8 3.0 6.5 -0.4 -2.3 -0.2 -2.6
Eye problems/disorders: Cataract 0.5 0.5 1.7 0.6 -0.0 1.3 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 3.7 1.3 0.8 -1.9 -0.6
Medication for cholesterol 0.1 0.2 0.6 -0.4 0.8 0.3 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.1 0.4 1.1 0.7 0.6
Back pain experienced in last month 0.3 0.4 0.7 0.8 0.6 -0.5 0.4
Mineral and other dietary supplements 2.2 3.0 5.9 0.9 1.4 -2.4 -1.8
Breast cancer (self-reported) 1.1 1.3 3.6 1.0 1.9 -0.1 0.7
Asthma (self-reported) 0.8 1.6 2.4 1.5 1.3 -1.3 -0.9
Osteoporosis (self-reported) 1.3 1.7 2.8 -1.3 -0.5 1.7 1.4
Osteoarthritis (self-reported) 0.2 0.3 0.6 0.8 -0.2 -0.7 0.3
Medication: Aspirin 0.3 0.4 0.6 0.7 -0.6 -0.8 -0.4
Medication: Gliclazide 1.6 1.9 4.1 0.6 -0.4 -2.0 -1.7
Illnesses of father: None of the above (group 1) 0.4 0.5 1.1 0.5 1.1 0.1 0.8
Smoking status: Current 0.2 0.3 0.9 -1.0 0.6 0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 3.7 -0.7 0.9 1.9 0.4
Whole body water mass 0.3 1.6 4.9 0.6 1.1 -2.2 0.2
Leg predicted mass (right) 0.3 1.7 5.5 0.8 0.9 -2.3 0.1
Arm fat mass (left) 0.1 0.2 0.5 -0.2 0.7 -0.6 -0.2
Number of self-reported non-cancer illnesses 0.4 0.7 1.2 1.1 0.3 -0.9 -0.9
Average weekly champagne plus white wine intake 2.0 2.7 5.8 -0.1 -2.4 -1.0 -2.0
Miserableness 0.8 1.3 3.7 0.2 -1.1 -0.6 -1.9
Guilty feelings 1.8 2.7 6.6 -1.8 -2.6 1.0 -0.2
Wears glasses or contact lenses 1.4 1.6 3.7 1.4 0.4 1.9 0.7
Ever taken oral contraceptive pill 0.2 0.2 0.6 0.4 0.8 -0.2 -0.1
Hearing aid user 1.4 1.5 2.4 -1.6 -1.1 -1.4 0.7
Mother’s age at death 1.1 1.3 1.7 -1.2 1.3 1.1 1.0
Financial situation satisfaction 0.2 0.2 0.8 -0.2 -0.1 0.9 0.1
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.7 -0.6 0.2 -1.3 -0.1
Commuting to job workplace: Public transport 0.7 0.8 1.7 -0.4 -1.2 -0.2 -1.3
Eye problems/disorders: Glaucoma 0.6 0.7 2.4 -0.2 -0.5 1.5 0.5
Medication: Blood pressure 0.2 0.3 0.8 0.2 -0.9 -0.7 -0.2
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.0 -0.5 -0.3 -1.0 0.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.2 -0.6 -1.0 0.4 1.5
High cholesterol (Self-reported) 0.6 1.1 1.9 1.2 1.4 -0.6 0.8
Medication: Bendroflumethiazide 0.7 1.0 1.6 0.2 -1.2 -0.9 -1.3
Medication: Paracetamol 0.4 0.6 0.8 -0.9 -0.9 -0.8 -0.4
Medication: Lisinopril 0.7 0.9 1.5 1.0 0.4 1.0 1.2
Medication: Atorvastatin 0.7 0.9 2.5 0.9 0.1 0.5 1.6
Illnesses of father: High blood pressure 1.7 2.1 3.3 -1.8 -1.8 1.3 -0.7
Alcohol drinker status: Never 0.9 1.1 2.8 -0.9 -1.7 -0.2 0.8
Ever smoked 0.4 0.7 1.6 -0.5 0.6 1.2 0.7
Basal metabolic rate 0.3 1.5 4.6 0.5 1.1 -2.1 0.1
Leg fat percentage (left) 0.1 0.4 0.8 -0.1 0.9 -0.6 -0.7
Arm fat-free mass (left) 0.2 1.1 3.5 0.2 0.9 -1.9 0.2
Number of operations (self-reported) 0.6 0.8 2.4 0.4 -0.2 -0.9 -1.5
Average weekly beer plus cider intake 0.2 0.3 0.7 0.0 0.8 -0.3 0.6
Irritability 0.5 0.9 1.0 1.0 0.9 1.0 0.9
Risk taking 0.1 0.2 0.6 0.3 0.2 -0.8 -0.1
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.8 1.4 -0.8 -1.1 -0.6
Fractured/broken bones in last 5 years 0.5 0.6 1.7 -0.3 -0.1 1.3 -0.9
Age started oral contraceptive pill 1.2 1.5 2.8 -1.1 -1.7 0.9 1.0
Diastolic blood pressure, automated reading 0.5 1.7 4.9 -1.1 -0.8 2.2 0.2
Ever depressed for a whole week 1.2 1.4 4.8 0.1 -0.6 -0.7 -2.2
Unable to work because of sickness or disability 0.7 0.8 1.6 -1.3 -0.3 -0.5 -1.2
Commuting to job workplace: Cycle 0.6 0.7 2.6 0.5 0.1 -1.6 -0.2
Myopia 0.6 0.9 2.2 0.8 -0.7 -0.2 -1.5
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.5 -1.9 0.4 0.3 0.7
Cholesterol lowering medication 0.5 0.7 1.5 -0.8 0.7 0.1 1.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.2 -1.5 -0.4 0.4 1.0
Pain experienced in last month 0.8 1.3 4.2 -0.6 0.5 2.0 0.6
Supplements: Calcium 1.3 1.4 3.1 -0.9 -1.1 1.8 0.8
Basal cell carcinoma (self-reported) 0.6 0.8 1.7 0.4 1.1 -0.1 1.3
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.9 0.3 -1.0 0.0 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.4 -0.4 -0.9 -1.2 -0.3
Heart disease (siblings) 0.6 0.8 1.2 0.8 -1.1 -0.6 -1.0
Alcohol drinker status: Previous 1.8 2.0 4.1 0.1 0.2 -2.0 -2.0
Pack years of smoking 0.3 0.4 1.4 0.3 0.3 -1.2 -0.5
Impedance of whole body 0.4 2.1 4.4 -0.9 -1.0 2.1 -1.6
Leg fat mass (left) 0.2 0.7 1.3 0.2 1.1 -1.1 -0.3
Arm predicted mass (left) 0.2 1.0 3.3 0.0 0.7 -1.8 0.1