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chr7:43,821,453-45,801,046

Best TWAS P=1.88e-69 · Best GWAS P=1.08e-71 conditioned to 7.55e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	H2AFV	0.14	0.08	lasso	8	0.08	1.8e-10	-16.38	17.6	1.9e-69	-0.92	0.01	0.99	TRUE
21	GTEx	Thyroid	TBRG4	0.15	0.06	enet	14	0.08	9.1e-07	-5.07	-7.0	1.8e-12	0.17	0.99	0.00	TRUE
27	YFS	Blood	TMED4	0.13	0.12	lasso	13	0.15	1.3e-45	4.88	-5.8	9.1e-09	0.18	1.00	0.00	TRUE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DBNL	0.23	0.07	enet	9	0.10	2.6e-11	4.70	-5.5	3.7e-08	0.08	0.00	0.98	TRUE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C7orf40	0.07	0.00	blup	29	0.01	9.0e-03	-0.20	5.3	9.0e-08	-0.10	0.03	0.18	TRUE
18	GTEx	Testis	H2AFV	0.22	0.06	lasso	4	0.05	3.2e-03	-16.38	-17.4	1.2e-67	0.91	0.02	0.94	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	ZMIZ2	0.06	0.03	blup	35	0.03	3.8e-04	11.59	15.9	3.0e-57	-0.87	0.02	0.97	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	H2AFV	0.15	0.14	lasso	3	0.14	1.3e-13	14.67	15.7	2.4e-55	-0.79	0.90	0.10	FALSE
3	GTEx	Artery Aorta	H2AFV	0.10	0.08	lasso	2	0.06	1.9e-04	14.67	14.7	1.0e-48	-0.72	0.42	0.07	FALSE
23	NTR	Blood	ZMIZ2	0.08	0.06	enet	17	0.06	1.5e-18	16.04	-14.4	6.3e-47	0.72	1.00	0.00	FALSE
20	GTEx	Thyroid	H2AFV	0.15	0.04	lasso	6	0.08	1.8e-06	14.67	13.9	5.2e-44	-0.66	0.06	0.88	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	H2AFV	0.08	0.03	enet	11	0.06	1.9e-06	14.70	12.8	1.2e-37	-0.67	0.04	0.75	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	H2AFV	0.05	0.04	blup	40	0.04	4.5e-08	14.70	12.6	1.6e-36	-0.62	0.71	0.29	FALSE
6	GTEx	Brain Hypothalamus	TMED4	0.37	-0.01	enet	36	-0.01	6.3e-01	-16.33	11.9	9.3e-33	-0.45	0.04	0.27	FALSE
13	GTEx	Lung	DDX56	0.15	0.03	enet	17	0.08	1.6e-06	-2.45	-10.3	6.0e-25	0.53	0.15	0.79	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPIA	0.05	0.02	enet	5	0.03	7.7e-05	-12.04	-10.1	7.9e-24	0.61	0.03	0.47	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	ZMIZ2	0.10	0.06	enet	15	0.07	1.3e-09	14.70	9.9	4.0e-23	-0.39	1.00	0.00	FALSE
17	GTEx	Stomach	SNORA5C	0.14	0.00	enet	21	0.02	2.5e-02	-17.88	-9.7	2.3e-22	0.67	0.02	0.77	FALSE
8	GTEx	Cells Transformed fibroblasts	ZMIZ2	0.12	0.09	lasso	4	0.06	2.3e-05	-9.04	-9.0	2.5e-19	0.40	0.62	0.27	FALSE
16	GTEx	Nerve Tibial	ZMIZ2	0.12	0.06	lasso	5	0.06	5.1e-05	-6.35	9.0	2.6e-19	-0.40	0.70	0.02	FALSE
5	GTEx	Brain Hypothalamus	AC004453.8	0.54	0.13	lasso	7	0.16	1.8e-04	-0.67	-8.3	7.5e-17	0.52	0.05	0.20	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TBRG4	0.05	0.01	blup	61	0.03	6.8e-04	-3.91	-6.9	5.6e-12	0.18	0.10	0.73	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C7orf40	0.03	0.02	enet	4	0.02	2.4e-03	-7.88	6.8	1.0e-11	-0.15	0.00	0.81	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	TBRG4	0.09	0.09	blup	61	0.09	3.2e-09	-5.64	-6.6	3.1e-11	0.14	0.30	0.70	FALSE
11	GTEx	Esophagus Mucosa	TBRG4	0.12	0.07	lasso	9	0.08	3.6e-06	-5.64	-6.5	6.1e-11	0.11	0.92	0.00	FALSE
4	GTEx	Artery Tibial	TBRG4	0.11	0.06	enet	12	0.08	1.6e-06	-4.90	-6.4	1.5e-10	0.16	0.97	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TBRG4	0.23	0.21	enet	27	0.22	5.6e-27	-5.64	-6.3	3.1e-10	0.12	1.00	0.00	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	TBRG4	0.18	0.19	lasso	6	0.22	3.8e-27	-4.90	-6.1	1.1e-09	0.13	1.00	0.00	FALSE
10	GTEx	Cells Transformed fibroblasts	NACAD	0.13	0.11	lasso	9	0.11	1.2e-08	-5.42	6.0	2.4e-09	-0.18	0.98	0.01	FALSE
14	GTEx	Lung	NACAD	0.07	0.02	lasso	4	0.02	1.1e-02	-4.94	5.9	3.8e-09	-0.13	0.13	0.03	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	TBRG4	0.08	0.09	lasso	6	0.10	1.5e-10	-5.64	-5.8	6.0e-09	0.13	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	TBRG4	0.03	0.03	lasso	3	0.02	1.2e-05	-5.64	-5.7	9.8e-09	0.10	0.20	0.76	FALSE
9	GTEx	Cells Transformed fibroblasts	TBRG4	0.13	0.13	lasso	1	0.12	5.7e-09	-5.64	-5.6	1.8e-08	0.09	1.00	0.00	FALSE
22	METSIM	Adipose	TBRG4	0.05	0.04	lasso	2	0.04	3.1e-06	-5.64	-5.6	1.8e-08	0.09	0.97	0.00	FALSE
19	GTEx	Testis	TBRG4	0.32	0.27	enet	13	0.21	8.7e-10	-4.90	-5.5	4.2e-08	0.21	1.00	0.00	FALSE
26	YFS	Blood	DDX56	0.04	0.03	enet	38	0.04	1.6e-12	-2.14	-5.3	9.7e-08	0.18	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	NACAD	0.02	0.02	blup	56	0.00	1.1e-01	-5.05	5.3	1.2e-07	-0.14	0.09	0.20	FALSE
12	GTEx	Lung	TBRG4	0.11	0.08	lasso	4	0.08	6.4e-07	-5.07	-5.2	2.0e-07	0.15	0.99	0.00	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX56	0.03	0.02	blup	44	0.02	2.0e-03	4.94	-5.2	2.2e-07	0.11	0.08	0.84	FALSE
15	GTEx	Muscle Skeletal	CCM2	0.09	0.09	lasso	2	0.06	7.3e-07	-5.22	-5.2	2.3e-07	0.17	1.00	0.00	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	TBRG4	0.42	0.26	lasso	9	0.30	2.1e-10	-5.64	-5.2	2.4e-07	0.13	0.85	0.01	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	DBNL	0.30	0.07	lasso	5	0.13	1.6e-13	4.70	-5.1	2.7e-07	0.06	0.00	0.98	FALSE