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chr16:3,301,360-5,627,737

Best TWAS P=3.53e-17 · Best GWAS P=7.67e-23 conditioned to 9.14e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
75	The Cancer Genome Atlas	Glioblastoma Multiforme	CORO7	0.12	0.06	lasso	6	0.06	8.3e-03	7.412	-8.4	3.5e-17	0.08	0.01	0.85	TRUE
43	GTEx	Muscle Skeletal	MGRN1	0.16	0.06	lasso	7	0.15	1.1e-14	7.684	8.0	1.6e-15	0.01	0.99	0.00	TRUE
60	GTEx	Thyroid	RP11-95P2.1	0.15	0.10	lasso	5	0.10	3.9e-08	-7.295	7.5	6.8e-14	-0.03	0.90	0.05	TRUE
68	ROSMAP	Brain Pre-frontal Cortex	RP11-462G12.1	0.11	0.07	enet	18	0.06	1.1e-08	5.626	7.0	2.7e-12	0.04	1.00	0.00	TRUE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC14L5	0.02	0.00	blup	81	0.01	6.2e-03	4.093	5.9	3.3e-09	-0.54	0.07	0.17	TRUE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF500	0.11	0.01	blup	49	0.03	8.8e-05	4.480	-5.8	6.2e-09	0.18	0.00	0.17	TRUE
30	GTEx	Colon Transverse	NMRAL1	0.38	0.19	enet	31	0.19	2.3e-09	6.222	7.7	9.7e-15	-0.21	1.00	0.00	FALSE
38	GTEx	Heart Left Ventricle	MGRN1	0.32	0.10	enet	18	0.33	3.6e-18	7.189	7.7	1.4e-14	0.00	0.98	0.00	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC342346	0.06	0.02	blup	34	0.02	1.2e-03	6.375	-7.6	2.7e-14	0.14	0.70	0.09	FALSE
49	GTEx	Pituitary	NMRAL1	0.31	0.18	enet	12	0.23	1.9e-06	6.130	7.3	2.6e-13	-0.13	0.70	0.02	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	NMRAL1	0.47	0.28	lasso	4	0.26	4.3e-10	6.222	7.2	7.0e-13	-0.11	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CORO7	0.08	0.08	lasso	2	0.06	4.3e-08	7.112	-7.1	1.1e-12	0.13	0.99	0.01	FALSE
11	GTEx	Brain Cerebellar Hemisphere	CDIP1	0.47	0.47	lasso	6	0.52	1.2e-15	6.250	7.0	1.8e-12	-0.12	1.00	0.00	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	CDIP1	0.13	0.18	lasso	2	0.17	3.6e-21	6.778	7.0	2.0e-12	-0.15	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf5	0.02	0.03	blup	37	0.03	9.7e-08	6.222	-7.0	2.0e-12	0.13	0.96	0.04	FALSE
6	GTEx	Adipose Visceral Omentum	NMRAL1	0.36	0.27	enet	20	0.27	3.7e-14	6.222	7.0	2.1e-12	-0.15	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	CORO7	0.26	0.43	lasso	3	0.44	5.0e-54	6.472	-6.9	4.0e-12	0.12	0.63	0.37	FALSE
42	GTEx	Muscle Skeletal	CDIP1	0.07	0.07	lasso	2	0.06	6.1e-07	6.778	-6.8	7.8e-12	0.16	0.99	0.00	FALSE
16	GTEx	Brain Cerebellum	NMRAL1	0.81	0.55	lasso	10	0.62	4.6e-23	6.130	6.8	1.1e-11	-0.13	1.00	0.00	FALSE
35	GTEx	Esophagus Muscularis	NMRAL1	0.30	0.35	enet	16	0.33	7.2e-21	6.250	6.8	1.1e-11	-0.18	1.00	0.00	FALSE
46	GTEx	Nerve Tibial	HMOX2	0.24	0.07	lasso	7	0.07	1.3e-05	6.222	6.8	1.4e-11	-0.13	0.99	0.00	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	C16orf5	0.03	0.03	lasso	2	0.02	1.3e-03	6.778	-6.8	1.4e-11	0.15	0.33	0.07	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	CDIP1	0.16	0.10	lasso	7	0.06	6.8e-03	6.472	-6.7	1.6e-11	0.13	0.37	0.04	FALSE
57	GTEx	Thyroid	CDIP1	0.15	0.14	lasso	3	0.15	1.5e-11	5.711	-6.7	2.0e-11	0.15	1.00	0.00	FALSE
8	GTEx	Artery Coronary	NMRAL1	0.40	0.34	lasso	5	0.34	3.5e-12	6.778	6.7	2.1e-11	-0.15	1.00	0.00	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	C16orf5	0.07	0.07	blup	37	0.07	1.1e-07	6.222	-6.7	2.2e-11	0.14	0.98	0.02	FALSE
63	METSIM	Adipose	NMRAL1	0.18	0.22	bslmm	447	0.22	8.8e-33	6.130	6.7	2.7e-11	-0.11	1.00	0.00	FALSE
53	GTEx	Spleen	NMRAL1	0.35	0.20	lasso	6	0.23	1.6e-06	6.222	6.7	2.8e-11	-0.11	0.10	0.07	FALSE
51	GTEx	Skin Sun Exposed Lower leg	CDIP1	0.08	0.06	lasso	3	0.05	6.8e-05	6.375	-6.6	3.4e-11	0.14	0.65	0.01	FALSE
56	GTEx	Testis	NMRAL1	0.27	0.20	enet	6	0.22	2.4e-10	6.375	6.6	3.5e-11	-0.14	1.00	0.00	FALSE
13	GTEx	Brain Cerebellum	CDIP1	0.47	0.54	lasso	7	0.52	8.3e-18	6.250	6.6	3.6e-11	-0.13	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	NMRAL1	0.15	0.12	lasso	5	0.12	1.6e-09	6.250	6.6	4.9e-11	-0.13	1.00	0.00	FALSE
27	GTEx	Colon Sigmoid	CDIP1	0.25	0.04	lasso	6	0.04	1.6e-02	6.372	-6.6	5.0e-11	0.13	0.10	0.05	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	CDIP1	0.25	0.24	lasso	5	0.25	1.2e-09	5.711	-6.6	5.5e-11	0.16	0.98	0.00	FALSE
4	GTEx	Adipose Subcutaneous	NMRAL1	0.31	0.33	lasso	4	0.35	9.0e-30	6.250	6.5	7.4e-11	-0.13	1.00	0.00	FALSE
25	GTEx	Cells Transformed fibroblasts	ANKS3	0.09	0.05	enet	22	0.03	2.7e-03	-4.556	-6.5	8.1e-11	0.10	0.52	0.02	FALSE
52	GTEx	Skin Sun Exposed Lower leg	NMRAL1	0.12	0.05	enet	9	0.04	1.6e-04	6.401	6.5	8.4e-11	-0.14	0.99	0.00	FALSE
20	GTEx	Breast Mammary Tissue (Male)	NMRAL1	0.20	0.11	lasso	4	0.10	2.4e-03	6.375	6.5	9.5e-11	-0.13	0.10	0.05	FALSE
3	GTEx	Adipose Subcutaneous	HMOX2	0.13	0.05	lasso	6	0.04	2.2e-04	5.955	6.5	1.0e-10	-0.14	0.97	0.00	FALSE
7	GTEx	Artery Aorta	NMRAL1	0.43	0.42	lasso	8	0.42	4.7e-25	6.250	6.5	1.0e-10	-0.12	1.00	0.00	FALSE
9	GTEx	Artery Tibial	CDIP1	0.14	0.14	lasso	3	0.16	1.0e-12	6.375	-6.4	1.3e-10	0.15	1.00	0.00	FALSE
33	GTEx	Esophagus Mucosa	NMRAL1	0.23	0.13	lasso	4	0.12	2.7e-08	6.375	6.4	1.3e-10	-0.14	1.00	0.00	FALSE
28	GTEx	Colon Sigmoid	NMRAL1	0.43	0.35	lasso	5	0.31	1.7e-11	6.250	6.4	1.4e-10	-0.12	1.00	0.00	FALSE
23	GTEx	Cells Transformed fibroblasts	CDIP1	0.33	0.35	lasso	3	0.36	1.3e-28	6.375	-6.4	1.6e-10	0.15	1.00	0.00	FALSE
62	METSIM	Adipose	CDIP1	0.07	0.06	lasso	5	0.08	2.8e-12	5.792	-6.4	1.6e-10	0.16	1.00	0.00	FALSE
41	GTEx	Lung	NMRAL1	0.16	0.11	enet	3	0.13	3.4e-10	6.250	6.4	1.8e-10	-0.12	1.00	0.00	FALSE
15	GTEx	Brain Cerebellum	HMOX2	0.21	0.15	lasso	3	0.14	7.2e-05	6.430	6.4	1.9e-10	-0.11	0.52	0.07	FALSE
59	GTEx	Thyroid	NMRAL1	0.18	0.14	lasso	3	0.15	2.4e-11	6.372	6.4	2.0e-10	-0.15	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	HMOX2	0.02	0.03	lasso	2	0.02	3.9e-03	5.832	6.3	2.1e-10	-0.17	0.02	0.95	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	CORO7	0.19	0.29	bslmm	426	0.29	5.8e-38	6.472	-6.3	2.2e-10	0.11	1.00	0.00	FALSE
47	GTEx	Nerve Tibial	NMRAL1	0.32	0.37	lasso	3	0.36	5.2e-27	6.250	6.3	2.3e-10	-0.12	1.00	0.00	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	HMOX2	0.28	-0.01	lasso	5	-0.01	7.1e-01	6.222	-6.3	2.4e-10	0.14	0.07	0.18	FALSE
10	GTEx	Artery Tibial	NMRAL1	0.38	0.30	enet	15	0.36	1.2e-29	6.250	6.3	2.7e-10	-0.12	1.00	0.00	FALSE
19	GTEx	Breast Mammary Tissue	NMRAL1	0.17	0.18	lasso	2	0.15	5.2e-08	6.250	6.3	2.8e-10	-0.11	0.98	0.00	FALSE
12	GTEx	Brain Cerebellar Hemisphere	NMRAL1	0.62	0.66	lasso	3	0.68	2.2e-23	6.250	6.3	3.6e-10	-0.11	1.00	0.00	FALSE
37	GTEx	Heart Atrial Appendage	NMRAL1	0.27	0.25	lasso	2	0.23	1.1e-10	6.250	6.3	3.6e-10	-0.11	1.00	0.00	FALSE
39	GTEx	Heart Left Ventricle	NMRAL1	0.36	0.26	enet	12	0.28	4.4e-15	5.784	6.2	4.1e-10	-0.14	1.00	0.00	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	NMRAL1	0.19	0.12	lasso	3	0.11	1.3e-06	6.222	6.2	4.7e-10	-0.12	0.98	0.00	FALSE
58	GTEx	Thyroid	HMOX2	0.12	0.06	lasso	3	0.04	3.3e-04	6.372	6.2	4.7e-10	-0.12	0.28	0.06	FALSE
54	GTEx	Stomach	NMRAL1	0.16	0.18	lasso	1	0.16	6.5e-08	6.222	6.2	4.9e-10	-0.12	0.95	0.01	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	NMRAL1	0.31	0.25	lasso	6	0.30	8.0e-40	6.130	6.2	5.1e-10	-0.09	1.00	0.00	FALSE
45	GTEx	Nerve Tibial	CDIP1	0.20	0.12	lasso	5	0.13	1.4e-09	5.832	-6.2	5.3e-10	0.17	1.00	0.00	FALSE
26	GTEx	Cells Transformed fibroblasts	RP11-95P2.1	0.13	0.11	lasso	3	0.12	2.0e-09	-5.410	6.1	1.2e-09	-0.05	0.81	0.19	FALSE
29	GTEx	Colon Transverse	CDIP1	0.21	0.07	lasso	4	0.09	4.5e-05	5.832	-6.1	1.3e-09	0.13	0.88	0.00	FALSE
61	GTEx	Whole Blood	NMRAL1	0.19	0.14	lasso	5	0.20	3.6e-18	6.778	6.0	1.4e-09	-0.10	1.00	0.00	FALSE
64	METSIM	Adipose	NUDT16L1	0.06	0.03	bslmm	392	0.04	2.2e-06	-3.829	-6.0	1.5e-09	-0.04	0.99	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DNAJA3	0.23	0.29	lasso	3	0.29	1.2e-35	5.955	6.0	2.0e-09	-0.13	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf5	0.05	0.07	enet	4	0.07	1.1e-07	5.832	-6.0	2.2e-09	0.16	0.99	0.01	FALSE
5	GTEx	Adipose Subcutaneous	RP11-95P2.1	0.12	0.01	lasso	3	0.02	1.0e-02	-5.284	5.9	4.6e-09	-0.07	0.05	0.06	FALSE
18	GTEx	Breast Mammary Tissue	UBN1	0.21	0.05	enet	29	0.09	1.9e-05	0.022	5.8	4.9e-09	0.00	0.35	0.03	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf5	0.02	0.02	lasso	3	0.02	4.5e-03	5.291	-5.8	5.5e-09	0.14	0.27	0.06	FALSE
21	GTEx	Breast Mammary Tissue (Female)	NMRAL1	0.29	0.01	lasso	6	0.00	2.7e-01	5.586	5.8	5.7e-09	-0.10	0.08	0.05	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	NMRAL1	0.17	0.20	enet	14	0.21	3.3e-23	5.955	5.8	7.3e-09	-0.13	0.21	0.79	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	ANKS3	0.08	0.00	blup	396	0.02	1.5e-03	-3.447	-5.7	1.1e-08	0.10	0.21	0.02	FALSE
34	GTEx	Esophagus Muscularis	CDIP1	0.35	0.16	lasso	11	0.20	3.9e-12	5.832	-5.7	1.2e-08	0.16	1.00	0.00	FALSE
70	YFS	Blood	NMRAL1	0.25	0.22	lasso	7	0.32	6.7e-107	5.955	5.7	1.2e-08	-0.08	1.00	0.00	FALSE
40	GTEx	Lung	ROGDI	0.20	0.10	lasso	5	0.06	1.4e-05	-3.798	-5.6	1.9e-08	0.31	0.97	0.00	FALSE
44	GTEx	Muscle Skeletal	NMRAL1	0.27	0.22	enet	28	0.31	2.0e-30	5.692	5.6	2.6e-08	-0.11	1.00	0.00	FALSE
55	GTEx	Testis	ROGDI	0.17	0.09	enet	10	0.10	2.1e-05	-3.829	5.5	4.0e-08	-0.10	0.43	0.03	FALSE
36	GTEx	Heart Atrial Appendage	MGRN1	0.33	0.30	enet	13	0.32	7.1e-15	-1.966	5.3	9.8e-08	0.01	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf5	0.09	0.10	lasso	2	0.06	1.6e-04	5.486	-5.3	9.8e-08	0.13	0.51	0.13	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	SEC14L5	0.04	0.01	lasso	4	0.03	4.5e-04	-5.665	5.3	1.2e-07	-0.64	0.09	0.58	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEPT12	0.11	0.04	enet	15	0.09	1.7e-17	4.649	-5.3	1.4e-07	0.10	0.01	0.96	FALSE
48	GTEx	Ovary	NMRAL1	0.33	0.16	lasso	3	0.12	7.0e-04	5.958	5.3	1.5e-07	-0.13	0.11	0.15	FALSE
74	The Cancer Genome Atlas	Colon Adenocarcinoma	UBN1	0.05	0.04	enet	7	0.05	4.2e-04	5.524	-5.2	1.6e-07	0.02	0.01	0.90	FALSE
84	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NMRAL1	0.05	0.03	blup	32	0.04	2.1e-05	6.392	5.2	1.9e-07	-0.03	0.01	0.97	FALSE
14	GTEx	Brain Cerebellum	ZNF500	0.44	0.20	enet	24	0.21	8.0e-07	-2.377	-5.2	2.5e-07	0.10	0.91	0.00	FALSE