TWAS hub - SEC14L5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0605	0.0214	7.3e-04	0.014	0.011	0.006	0.013	0.005	2.9e-03	6.4e-03	3.3e-02	3.8e-03	6.0e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.1360	0.0310	6.3e-08	0.029	0.082	0.112	0.088	0.057	9.4e-05	9.8e-11	3.4e-14	2.1e-11	8.1e-08
3	TCGA	Breast Invasive Carcinoma	0.0239	0.0126	3.2e-03	0.004	0.008	-0.001	NA	0.003	3.9e-02	6.2e-03	4.7e-01	NA	6.5e-02
4	TCGA	Lung Adenocarcinoma	0.0435	0.0200	1.7e-03	0.012	0.025	0.022	NA	0.026	1.2e-02	5.4e-04	1.3e-03	NA	4.5e-04
5	TCGA	Thyroid Carcinoma	0.0920	0.0290	2.1e-08	0.077	0.083	0.066	NA	0.076	5.8e-08	1.7e-08	4.8e-07	NA	6.6e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Medication for hormone replacement therapy	7.2	8.1	11.5	-3.0	2.4	-3.4	-2.1	-3.2
Pulse wave Arterial Stiffness index	5.3	6.2	10.0	-3.2	1.8	-2.4	-2.7	-2.2
Pulse wave peak to peak time	5.2	6.2	12.0	3.5	-1.4	2.2	2.7	2.1
Osteoarthritis (self-reported)	3.7	4.8	10.4	-3.2	1.5	-2.1	-2.3	-1.3
Bipolar Disorder (2018)	3.4	5.4	8.6	-2.5	-0.3	-2.5	-2.9	-2.3
Commuting to job workplace: Car/motor vehicle	3.3	3.8	9.5	0.7	-0.6	3.1	1.6	2.5
Average weekly beer plus cider intake	3.2	4.6	10.0	-3.2	0.6	-1.7	-2.0	-2.4
Qualifications: CSEs or equivalent	3.1	4.0	12.2	-3.5	0.5	-0.6	-1.9	-1.9
Mineral and other dietary supplements	2.9	4.0	9.7	3.1	-0.6	2.0	0.9	2.2
Loud music exposure frequency	2.7	3.0	5.7	-2.4	0.9	-2.0	-0.5	-2.0
Major Depression (MDD)	2.6	3.1	11.7	0.7	-3.4	1.2	0.0	1.4
Falls in the last year	2.5	3.4	10.5	-1.7	3.2	-0.5	-1.7	-0.8
Medication: Amlodipine	2.5	3.5	4.6	-2.1	1.4	-1.8	-2.1	-1.7
Risk taking	2.3	3.4	15.4	-3.9	1.1	-0.0	-0.1	-0.6
Happiness	2.2	2.6	6.5	0.8	-2.0	1.0	2.5	1.0
Noisy workplace	2.2	2.7	4.0	-2.0	1.3	-2.0	-1.4	-1.4
Miserableness	2.1	3.6	6.8	-1.4	1.6	-1.7	-1.9	-2.6
Blood Platelet Count	2.0	22.8	35.0	4.1	-4.0	5.9	5.3	4.3
Frequency of depressed mood in last 2 weeks	2.0	2.8	5.2	-0.8	2.3	-2.0	-0.8	-1.8
Number of live births	2.0	2.8	3.9	1.9	-2.0	1.3	1.5	1.5
Medication: Gliclazide	2.0	2.3	5.0	-2.2	0.3	-1.6	-1.1	-1.7
Commuting to job workplace: Public transport	2.0	2.4	5.9	-0.2	2.4	-1.9	0.0	-1.6
Medication: Bendroflumethiazide	2.0	3.1	5.5	2.3	-1.7	1.7	1.8	1.1
Ovarian Cancer	1.9	2.5	4.5	-0.6	2.1	-2.0	-1.1	-1.6
Relative age voice broke	1.9	3.0	6.1	-1.1	1.8	-1.6	-2.5	-1.3
Trunk fat mass	1.9	8.0	25.7	5.1	-0.4	1.9	2.5	2.1
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	3.1	1.5	0.5	1.8	1.5	1.4
Whole body fat mass	1.8	7.6	23.1	4.8	-0.1	2.1	2.5	2.0
Waist circumference	1.7	6.3	21.7	4.7	-0.4	1.7	1.9	1.7
Weight	1.7	8.2	27.5	5.2	0.3	2.1	2.1	2.2
Peak expiratory flow (PEF)	1.7	4.0	14.5	3.8	-0.3	1.3	0.1	1.9
Pulse wave reflection index	1.7	2.1	5.1	-1.0	1.4	-1.2	-2.2	-1.1
Arm fat mass (left)	1.7	7.1	20.7	4.5	-0.2	2.1	2.3	2.2
Bipolar Disorder or Schizophrenia	1.6	3.9	7.3	-2.7	-2.0	-1.6	-1.8	-1.4
Depressed Affect (Nagel 2018)	1.6	3.3	9.5	-1.9	1.4	-1.2	-0.5	-3.1
Verbal and Numeric Reasoning (VNR)	1.6	3.9	8.7	3.0	1.9	1.6	1.2	1.8
Qualifications: A levels/AS levels or equivalent	1.6	3.5	7.7	2.8	2.2	1.2	0.4	1.7
Arm fat mass (right)	1.6	6.4	17.2	4.2	-0.1	2.3	2.2	2.1
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	5.0	2.2	0.5	1.9	0.4	2.0
Leg fat mass (right)	1.6	6.3	18.1	4.3	0.3	2.0	2.4	1.8
Ever had bowel cancer screening	1.6	1.9	4.1	-1.1	0.2	-2.0	-1.2	-1.6
Qualifications: nursing, teaching	1.6	2.4	9.6	3.1	1.6	-0.1	0.2	-0.3
Leg fat mass (left)	1.6	6.3	19.4	4.4	0.3	1.9	2.2	1.8
Intelligence (Savage-Jansen 2018)	1.5	4.7	12.2	3.5	0.9	1.3	2.4	1.9
Trunk fat percentage	1.5	6.0	18.2	4.3	-0.6	1.6	2.4	1.7
Current tobacco smoking	1.5	2.5	5.7	1.2	0.3	1.5	2.4	1.7
Fluid intelligence score	1.5	3.2	10.0	1.9	3.2	0.8	1.1	0.7
Health satisfaction	1.5	2.0	5.8	0.6	-0.2	1.6	2.4	1.0
Alcohol drinker status: Never	1.5	1.8	4.5	0.6	0.4	2.1	0.6	2.0
Neuroticism (Nagel 2018)	1.4	3.2	8.1	-2.5	0.3	-1.2	-0.2	-2.8
Sensitivity / hurt feelings	1.4	2.3	7.1	-2.7	0.4	-1.1	0.1	-1.8
Fed-up feelings	1.4	2.6	6.2	-1.6	0.8	-1.5	-1.2	-2.5
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	3.7	-0.9	1.9	-1.0	-1.4	-0.8
Had menopause	1.4	1.8	4.2	-0.2	1.3	-2.0	-1.1	-1.4
Pulse rate	1.4	2.4	11.7	-3.4	-0.2	-0.1	-0.1	-0.2
Body fat percentage	1.4	5.5	16.6	4.1	-0.4	1.6	2.4	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.6	0.2	1.5	-1.6	-1.2	-1.4
Loneliness, isolation	1.4	2.0	5.4	-1.2	2.3	-0.7	-0.5	-1.5
Lung FVC	1.3	6.4	21.6	4.7	-1.7	0.1	1.6	2.1
Forced vital capacity (FVC), Best measure	1.3	4.6	17.0	4.1	-2.0	0.4	0.0	1.4
Arm fat percentage (left)	1.3	5.2	14.2	3.8	-0.7	1.9	2.1	1.9
Eye problems/disorders: Cataract	1.3	1.5	7.0	-2.6	-0.5	-0.3	-0.3	-0.3
Back pain experienced in last month	1.3	1.9	3.8	-1.6	0.6	-1.6	0.4	-2.0
Ever taken oral contraceptive pill	1.3	1.4	3.4	0.1	-1.0	1.8	0.6	1.5
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.2	-1.3	0.8	-1.8	-0.2	-1.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.8	1.2	2.0	-1.3	0.0	-0.6
Depression (Nagel 2018)	1.2	1.7	3.2	-0.3	1.8	-1.7	0.0	-1.6
Ever had hysterectomy (womb removed)	1.2	1.4	4.6	-0.0	2.1	-0.3	1.3	-0.6
Leg fat-free mass (left)	1.2	6.6	21.3	4.6	0.6	1.7	2.0	2.1
Leg predicted mass (left)	1.2	6.6	21.2	4.6	0.6	1.7	2.0	2.1
Hair/balding pattern: Pattern 3	1.2	1.8	4.3	1.1	-2.1	1.0	1.1	1.2
Tense / ‘highly strung’	1.2	2.1	4.2	-2.1	-0.8	-1.4	-0.1	-1.9
Qualifications: College or University degree	1.2	3.8	10.0	3.2	1.1	1.6	1.4	1.8
Mean time to correctly identify matches	1.2	2.2	7.2	2.7	1.1	-0.5	1.5	-0.5
Leg fat-free mass (right)	1.2	6.2	22.3	4.7	0.7	1.3	1.6	2.0
Basal metabolic rate	1.2	6.6	22.0	4.7	0.7	1.8	1.9	2.0
Age started oral contraceptive pill	1.2	1.5	3.0	0.5	1.7	-1.7	0.5	-0.9
BMI	1.1	6.5	16.5	4.1	0.8	2.5	1.5	2.6
Body mass index (BMI)	1.1	4.8	11.8	3.4	-0.0	2.2	1.8	2.0
Forced vital capacity (FVC)	1.1	4.1	17.7	4.2	-0.9	0.3	0.3	1.4
Neuroticism score	1.1	2.3	4.6	-1.9	0.1	-1.4	-1.1	-2.2
Hip circumference	1.1	4.7	18.2	4.3	0.6	1.5	1.1	1.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	16.2	4.0	-0.5	0.7	0.0	1.3
Prospective memory result	1.1	1.3	3.3	-1.5	-0.1	-0.6	-0.8	-1.8
Neck or shoulder pain in last month	1.1	1.5	4.4	-2.1	-0.2	-0.9	-1.2	-1.0
Heart disease (mother)	1.1	1.4	4.4	-0.2	-2.1	0.7	1.3	0.5
Smoking status: Current	1.1	1.8	6.1	0.8	0.6	0.7	2.5	1.1
Leg predicted mass (right)	1.1	6.0	21.7	4.7	0.7	1.3	1.6	2.0
Arm predicted mass (left)	1.1	5.5	18.0	4.2	1.2	1.6	1.8	1.6
Age at First Birth	1.0	1.5	3.8	-1.4	2.0	-0.1	-0.7	-1.0
Crohns Disease (2012)	1.0	1.7	3.8	0.6	-0.0	2.0	0.7	1.9
Hearing difficulty/problems: Yes	1.0	1.6	4.9	0.1	-0.2	2.2	1.2	1.2
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.3	-0.9	1.1	-1.3	-0.2	-1.5
Systolic blood pressure, automated reading	1.0	3.0	7.2	-2.7	1.1	-1.4	-1.3	-1.7
Nervous feelings	1.0	1.9	3.7	-1.1	-0.6	-1.9	-1.6	-1.3
Pain all over the body in last month	1.0	1.1	1.5	-0.9	1.0	1.1	1.2	1.0
Arm fat percentage (right)	1.0	3.9	10.9	3.3	-0.2	1.7	1.8	1.5
Illnesses of mother	1.0	1.2	5.9	0.1	2.4	-0.1	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	13.3	3.6	-1.1	0.3	0.0	1.0
Leg fat percentage (right)	1.0	3.7	9.6	3.1	-0.2	1.8	2.0	1.3
Arm fat-free mass (right)	1.0	5.2	18.2	4.3	1.0	1.1	1.8	1.5
Medication: Seretide 50 evohaler	1.0	1.1	2.2	-0.3	-0.2	1.3	1.5	1.3
Chest pain or discomfort	1.0	1.4	4.1	-2.0	1.3	0.5	0.9	-0.7
Supplements: Vitamin C	1.0	1.2	5.7	-0.5	2.4	0.1	0.5	-0.2
Guilty feelings	1.0	1.5	3.8	-1.9	1.2	-0.1	-0.8	-1.3
Leg fat percentage (left)	1.0	3.7	11.8	3.4	-0.2	1.5	1.7	1.2
Number of operations (self-reported)	1.0	1.5	4.8	-2.2	0.5	0.0	-1.5	-0.6
Ever depressed for a whole week	1.0	1.3	3.2	-1.8	0.0	-1.2	-0.3	-1.3
Myopia	1.0	1.4	4.5	-0.8	-0.1	2.1	0.6	1.2
Pain experienced in last month	1.0	1.6	6.6	2.6	-0.3	0.5	1.0	0.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	5.0	-2.2	-0.6	-1.0	0.1	0.4
Schizophrenia vs Biploar Disorder	0.9	1.2	2.2	1.5	-0.6	1.3	1.3	0.1
Crohns Disease (2017)	0.9	1.9	2.8	1.7	-0.8	1.7	1.4	1.3
Prostate Cancer	0.9	1.3	3.8	-1.4	-0.8	-0.1	1.9	0.0
Mean Putamen Volume	0.9	1.1	4.7	0.1	-0.5	-0.2	2.2	0.7
Rheumatoid Arthritis	0.9	1.3	2.7	-0.6	0.7	-1.7	-1.6	-0.5
Triglycerides	0.9	1.5	4.1	0.6	2.0	-1.1	-1.0	-0.8
Neuroticism	0.9	2.1	5.9	-1.5	-0.3	-1.4	-0.2	-2.4
Medication: Metformin	0.9	1.3	3.0	-0.8	-1.7	0.8	0.5	1.3
Diabetes (father)	0.9	1.1	4.3	-0.8	-0.3	0.5	-2.1	0.2
Diabetes (mother)	0.9	1.2	2.0	0.4	-1.1	1.2	1.4	0.9
Stomach or abdominal pain in last month	0.9	1.1	1.6	-1.3	-0.6	1.0	1.1	1.0
Supplements: Glucosamine	0.9	1.2	2.4	-1.6	1.0	-0.9	0.0	-1.4
Heart attack	0.9	1.2	4.3	-2.1	-0.7	-0.6	0.3	0.8
Hair/balding pattern: Pattern 4	0.9	2.2	9.2	3.0	0.5	-0.4	0.8	-1.0
Number of children fathered	0.9	1.0	2.5	1.3	1.6	0.4	0.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.5	-1.0	-0.7	-1.6	-0.4	-1.1
Arm predicted mass (right)	0.9	4.4	15.4	3.9	0.8	0.8	1.8	1.4
Comparative height size at age 10	0.9	5.1	23.0	4.8	-0.8	-0.7	1.0	0.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.6	1.9	-0.7	0.4	1.0	0.4
Whole body fat-free mass	0.9	5.1	18.4	4.3	0.9	1.3	1.5	1.6
Mood swings	0.9	1.6	4.6	-0.8	0.7	-0.5	-1.4	-2.1
Whole body water mass	0.9	5.1	18.0	4.2	1.0	1.3	1.5	1.7
Arm fat-free mass (left)	0.9	4.5	15.8	4.0	1.2	1.1	1.5	1.3
Schizophrenia (2018)	0.8	1.6	5.6	-1.5	-2.4	-0.0	-0.1	-0.1
Worry (Nagel 2018)	0.8	1.7	2.5	-1.5	-1.2	-1.5	-0.1	-1.6
Alzheimer’s Disease (in mother)	0.8	1.0	2.5	0.9	-1.6	-1.0	0.4	-0.5
Reaction Time	0.8	1.6	4.0	2.0	0.5	0.8	1.6	0.6
Ulcerative Colitis	0.8	1.2	2.3	-0.9	-1.3	-1.0	-1.5	0.5
Waist Hip Ratio (WHR)	0.8	3.4	6.7	2.6	-1.8	1.2	1.9	1.3
Chronotype (morning person)	0.8	1.9	4.7	-0.8	0.6	2.2	-0.6	1.9
Medication: Atenolol	0.8	1.0	3.5	-0.9	1.9	0.2	-0.7	-0.3
Diabetes (self-reported)	0.8	1.2	3.3	-1.8	0.4	-0.8	-0.9	-1.0
Worrier / anxious feelings	0.8	1.5	3.9	-1.5	-0.5	-1.0	0.2	-2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.4	-1.5	-1.5	0.1	-0.8	0.1
Emphysema/chronic bronchitis	0.8	0.9	2.4	-1.6	1.1	-0.0	0.9	0.4
Overall health rating	0.8	1.6	4.4	-1.3	2.1	-0.5	-0.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	4.0	0.9	-2.0	0.4	-0.2	-0.1
Medication for cholesterol	0.8	1.3	2.2	1.5	-1.2	1.0	0.1	1.3
Breast cancer (self-reported)	0.8	1.0	2.5	-0.5	1.6	0.5	-0.2	-1.4
Body Mass Index (BMI) (2010)	0.7	0.9	2.0	1.4	1.0	0.7	0.8	-0.7
HbA1C	0.7	0.8	3.4	-0.3	-0.2	0.5	1.9	0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.1	-1.5	0.2	1.2	0.1	0.5
Systolic Blood Pressure	0.7	3.4	14.2	-3.8	-0.8	1.3	-0.3	0.2
Hand grip strength (right)	0.7	1.8	3.5	1.2	-1.5	1.3	-0.5	1.9
Medication: Levothyroxine sodium	0.7	1.2	2.6	1.3	0.2	1.3	-0.3	1.6
Trunk fat-free mass	0.7	3.9	14.1	3.8	0.9	1.2	1.1	1.3
Father’s age at death	0.7	1.0	1.7	1.3	0.0	-0.8	0.9	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.5	-0.1	1.1	1.6	0.5	0.7
Trunk predicted mass	0.7	4.0	14.7	3.8	0.9	1.2	1.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.6	-1.9	0.6	-0.2	-0.2	-1.0
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.1	-1.4	-1.1	-1.0	-0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.1	1.0	0.2	1.6	0.2	1.8
Medication: Allopurinol	0.7	1.0	1.7	1.0	0.4	0.7	1.2	1.3
Commuting to job workplace: Walk	0.7	0.8	2.2	1.3	1.5	0.1	-0.1	-0.1
Wears glasses or contact lenses	0.7	0.8	1.1	0.8	0.5	-1.0	1.0	-0.9
Irritability	0.7	1.2	3.2	-1.8	1.6	0.5	-0.3	-0.2
Unable to work because of sickness or disability	0.7	1.0	2.9	-1.3	1.7	0.2	0.3	-0.0
Alzheimer’s Disease (in father)	0.6	0.6	1.6	-0.6	-0.8	0.2	-0.6	1.3
Breast Cancer	0.6	1.6	5.0	2.2	0.3	1.2	1.1	0.1
Fasting Glucose	0.6	0.8	2.2	0.4	1.1	0.5	1.5	0.2
Primary Biliary Cirrhosis	0.6	0.8	2.8	-1.7	0.5	-0.7	0.2	-0.7
Schizophrenia (2014)	0.6	1.4	2.0	-1.3	-1.4	-1.2	-0.7	-1.1
Height	0.6	10.6	45.8	6.8	0.8	0.2	2.4	1.0
Average weekly spirits intake	0.6	0.8	1.4	-1.2	-0.9	0.8	0.9	-0.2
Medication: Co-codamol	0.6	0.7	1.4	0.6	0.1	-0.5	-1.2	-1.1
Pack years adult smoking proportion	0.6	0.9	1.5	1.0	-1.0	0.5	1.2	1.0
Average weekly fortified wine intake	0.6	0.7	1.9	0.1	1.4	-0.4	0.6	-1.0
Number of incorrect matches in round	0.6	1.0	2.8	-0.7	0.7	-0.8	-0.6	-1.7
Alcohol usually taken with meals	0.6	1.0	1.9	0.3	1.4	-1.0	-1.1	-1.0
Medication: Ramipril	0.6	0.7	1.6	-0.1	-0.3	0.9	1.1	1.3
Medication: Simvastatin	0.6	0.9	2.2	0.4	-1.5	-0.7	-1.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.1	0.5	1.5	-1.1	-0.5	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	-0.9	-0.0	-0.7	-1.4	0.1
Gout (self-reported)	0.6	0.9	2.2	1.1	0.2	0.8	0.4	1.5
Eye problems/disorders: None of the above	0.6	0.7	1.2	0.9	-0.1	1.1	0.8	0.8
Medication for pain relief, constipation, heartburn	0.6	1.0	4.1	0.2	-2.0	-0.2	0.2	0.9
Migraine (self-reported)	0.6	0.7	1.8	0.9	0.6	0.8	-0.2	1.3
Medication: Ibuprofen	0.6	0.8	1.8	-0.3	1.2	1.3	0.3	0.7
Pulse rate, automated reading	0.6	1.8	8.3	-2.9	-0.5	-0.4	0.0	0.5
Alcohol intake frequency.	0.6	1.5	3.3	1.8	-1.0	1.4	0.9	0.7
Had major operations	0.6	0.7	1.8	-1.4	-1.2	-0.3	-0.5	0.0
Medication: Aspirin	0.6	0.8	1.3	-0.7	0.7	-1.2	-1.1	-0.8
Knee pain experienced in last month	0.6	1.0	2.4	-1.6	0.0	-0.2	-1.5	-0.3
Hypertension (Self-reported)	0.6	1.8	4.5	-1.4	2.1	-0.5	-1.2	-0.9
Medication: Aspirin	0.6	0.7	1.5	-0.5	0.8	-1.2	-0.7	-0.8
Average weekly champagne plus white wine intake	0.6	0.8	2.4	-0.0	0.8	1.6	0.6	0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.7	-1.3	-0.3	-1.1	-0.1	-1.0
Supplements: Calcium	0.6	0.7	1.6	-0.3	0.9	-1.2	-0.4	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	2.4	-0.3	-0.8	-1.6	-0.8	0.2
Irritable Bowel Disease (IBD)	0.5	1.3	2.6	1.6	-0.8	1.1	0.4	1.4
Smoking Status	0.5	1.3	5.8	-0.6	-0.1	0.2	2.4	0.1
Number of treatments/medications taken	0.5	0.8	3.2	-0.2	1.8	0.7	0.3	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.8	-1.7	0.5	0.2	0.5	0.4
Hearing difficulty/problems with background noise	0.5	0.9	1.8	0.3	-0.9	1.2	1.4	0.4
Mouth/teeth dental problems: Dentures	0.5	0.8	1.2	1.1	-0.8	1.0	0.8	0.9
Medication: Cholesterol lowering	0.5	0.8	1.7	0.9	-0.6	0.8	0.8	1.3
Medication: Lansoprazole	0.5	0.6	2.3	1.5	0.7	-0.4	-0.3	-0.1
Exposure to tobacco smoke at home	0.5	0.6	1.0	0.3	-1.0	0.0	1.0	1.0
Birth weight of first child	0.5	1.0	3.4	1.9	-0.1	0.1	0.8	0.9
Glaucoma (self-reported)	0.5	0.6	1.3	-0.6	1.1	-0.6	-0.2	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	-1.1	1.0	-0.5	-0.5	-0.4
Comparative body size at age 10	0.5	1.4	3.5	0.8	-1.9	0.4	0.2	1.6
Worry too long after embarrassment	0.5	0.8	1.3	-0.9	-1.1	0.6	1.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.1	1.4	0.6	0.2	0.5	0.5
Suffer from ‘nerves’	0.5	0.7	2.9	0.3	0.2	-0.8	-1.7	-0.1
Illnesses of siblings: Diabetes	0.5	0.7	1.3	-1.0	-1.1	0.1	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.0	1.7	-0.6	0.9	-0.6	0.8
Diabetes diagnosed by doctor	0.5	0.8	3.6	-1.9	-0.0	-0.2	-0.7	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.8	-1.7	-0.5	-0.7	-0.3	0.1
Financial situation satisfaction	0.5	0.6	3.0	-1.7	-0.5	0.1	-0.1	0.1
Illnesses of father: High blood pressure	0.5	0.6	1.6	0.1	-0.8	1.3	0.1	0.9
Ever smoked	0.5	0.8	2.2	-1.1	0.2	-1.5	0.7	-0.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	0.1	-0.9	1.1	0.5	0.9
Neuroticism (2016)	0.4	0.5	1.6	-0.4	-0.4	1.3	0.7	0.5
Hand grip strength (left)	0.4	1.1	2.8	0.3	-1.7	0.2	-1.1	1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.0	-1.0	-0.8	-0.4	-0.6	0.4
Vitamin and mineral supplements	0.4	0.6	1.8	-0.3	-0.9	-0.2	-1.3	-0.4
High blood pressure	0.4	1.1	3.2	-0.9	1.8	0.1	-0.9	-0.6
Multivitamins +/- minerals	0.4	0.5	1.0	0.8	0.7	0.3	1.0	0.6
Past tobacco smoking	0.4	0.8	1.9	1.1	0.3	1.4	-0.6	0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.0	-0.8	0.5	1.1	0.8
Mouth/teeth dental problems	0.4	0.5	1.1	1.0	1.1	0.1	0.7	-0.1
Illnesses of siblings	0.4	0.5	1.9	1.4	-0.6	-0.0	0.6	0.0
Standing height	0.4	4.3	20.0	4.5	0.8	0.1	0.7	0.5
Length of working week for main job	0.4	0.5	2.0	-1.4	-0.5	0.3	-0.2	-0.3
Number of full brothers	0.4	0.5	1.0	0.2	-0.5	0.3	-1.0	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.9	-1.4	0.4	0.3	0.1	-0.8
Shortness of breath walking on level ground	0.4	0.5	1.5	-0.3	-0.7	-0.5	-0.5	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	0.2	-0.8	0.5	0.2	1.2
Leg pain on walking	0.4	0.5	1.0	-0.6	1.0	-0.5	-0.6	-0.5
Smoking status: Previous	0.4	0.5	1.4	-1.2	-0.9	-0.5	0.2	-0.5
Average weekly red wine intake	0.4	0.6	1.1	0.9	0.9	1.1	0.3	0.6
Long-standing illness, disability or infirmity	0.4	0.6	1.7	-1.3	0.8	-0.0	0.9	0.4
Friendships satisfaction	0.4	0.5	2.0	0.3	-1.4	-0.0	0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	-0.5	-0.2	-0.9	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.1	1.3	-1.4	0.0	-0.3	0.5
Diastolic blood pressure, automated reading	0.4	1.2	4.0	-2.0	1.0	0.7	-0.4	0.1
Commuting to job workplace: Cycle	0.4	0.5	1.7	-0.6	-0.1	-0.2	-0.3	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	0.2	-0.2	0.9	-0.2	1.2
HDL Cholesterol	0.3	0.4	1.2	-0.2	-1.1	0.3	0.9	-0.0
LDL Cholesterol	0.3	0.5	1.1	0.6	0.8	1.0	0.1	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.1	-1.4	-0.4	0.2	-0.7	-0.1
Lung FEV1/FVC ratio	0.3	1.4	4.0	-0.5	2.0	1.2	-1.0	0.4
Tanning	0.3	3.3	8.5	2.1	-1.1	1.3	2.9	0.9
Supplements: Zinc	0.3	0.3	0.9	-0.5	0.5	-0.9	0.0	-0.4
Maternal smoking around birth	0.3	0.5	1.1	-0.9	1.1	0.6	0.1	0.2
Taking other prescription medications	0.3	0.5	1.1	-0.9	1.1	0.3	-0.3	0.3
Age when periods started (menarche)	0.3	0.8	1.3	-1.1	-0.8	0.1	-0.8	-1.2
Chronic bronchitis/emphysema (father)	0.3	0.3	1.4	0.1	0.5	-0.2	-0.2	-1.2
High blood pressure (mother)	0.3	0.4	1.1	-0.8	-1.0	0.0	-0.3	-0.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	-0.8	0.9	-0.3	-0.1	0.6
Had other major operations	0.3	0.3	0.5	-0.6	0.0	0.7	-0.5	-0.6
Qualifications: None of the above	0.3	0.6	1.5	-0.5	-1.2	-0.8	-0.2	-0.9
Blood clot in the leg (DVT)	0.3	0.4	1.4	-0.2	0.3	-1.2	-0.4	-0.5
Medication: Paracetamol	0.3	0.5	1.3	0.7	0.4	1.2	0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.9	0.8	-0.8	0.2	-0.3
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.2	-1.1	-0.2	0.7	0.2
Wheeze or whistling in the chest in last year	0.3	0.6	2.6	-1.6	0.1	-0.3	-0.2	0.2
Angina (self-reported)	0.3	0.3	1.2	-0.3	0.6	-0.2	1.1	-0.1
Family relationship satisfaction	0.3	0.4	1.0	0.3	-0.7	0.3	1.0	0.3
Illnesses of father: Heart disease	0.3	0.5	1.8	-0.3	-1.3	0.2	0.5	0.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-0.7	0.2	-0.6	-1.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.9	-0.1	-0.0	-0.2	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	1.2	-0.2	1.1	-0.1	0.2	-0.5
High cholesterol (Self-reported)	0.3	0.6	2.0	0.8	-1.4	0.1	-0.1	0.3
Medication: Lisinopril	0.3	0.4	1.4	-0.1	1.2	0.2	-0.7	-0.3
Cholesterol lowering medication	0.3	0.4	0.9	-1.0	-0.8	-0.4	0.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.8	0.1	0.3	-1.3	-0.2	-0.6
Pack years of smoking	0.3	0.4	0.9	0.6	-0.7	0.0	0.9	0.5
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.6	-0.5	-0.1	-0.9	0.6
Coronary Artery Disease (CAD)	0.2	0.3	1.3	-0.0	-1.1	0.0	-0.1	0.2
Blood Red Count	0.2	1.5	2.3	-1.2	-1.5	-0.7	-1.5	-1.0
Blood White Count	0.2	1.3	2.7	-1.1	-0.2	1.4	1.6	0.8
Heel T-Score	0.2	1.7	4.8	2.2	-1.0	0.8	1.1	0.9
Hypothyroidism (self reported)	0.2	0.5	0.9	0.5	0.6	0.6	-0.9	0.9
Angina	0.2	0.3	1.3	0.1	0.4	-0.0	1.1	0.0
Severe depression (siblings)	0.2	0.2	0.6	0.3	-0.8	0.2	-0.5	-0.4
Impedance of leg (right)	0.2	0.8	3.0	-1.7	-0.8	0.2	-0.1	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	-0.1	0.3	-0.4	0.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.5	-0.6	-0.5	-0.5	0.4
Sitting height	0.2	1.7	6.8	2.6	1.2	-0.3	-0.4	0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.1	0.8	-0.5	-0.2	-0.3
Asthma	0.2	0.4	0.8	-0.4	-0.4	0.9	0.0	0.9
Impedance of arm (left)	0.2	0.7	3.1	-0.5	-1.8	-0.4	-0.3	-0.4
Breastfed as a baby	0.2	0.3	0.5	0.6	-0.7	0.3	-0.1	0.7
Headache pain in last month	0.2	0.4	1.1	1.0	-0.5	-0.2	-0.4	0.7
Medication: Omeprazole	0.2	0.2	0.9	-0.1	0.5	0.1	-0.3	0.9
Number of full sisters	0.2	0.3	0.6	0.0	0.8	-0.1	-0.7	-0.5
Asthma (self-reported)	0.2	0.3	0.7	-0.5	-0.3	0.8	-0.1	0.9
Hearing aid user	0.2	0.2	0.4	-0.3	0.6	0.6	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	-0.2	-0.3	-0.8	-0.2	-0.7
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.7	0.6	-0.2	-0.2	-0.6
Medication: Atorvastatin	0.2	0.2	0.3	-0.5	0.4	-0.4	0.5	0.4
Fractured/broken bones in last 5 years	0.2	0.3	1.1	-1.1	-0.4	0.1	0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.2	0.8	-1.1	-0.1	0.5	0.6
Impedance of whole body	0.2	0.9	2.2	-1.0	-1.5	-0.5	-0.5	-0.9
Lupus	0.1	0.2	0.8	0.9	0.3	0.3	-0.2	0.2
Blood Eosinophil Count	0.1	0.5	2.3	-1.5	0.1	0.3	0.2	-0.4
Allergy or Eczema	0.1	0.4	0.8	0.1	0.1	0.5	0.9	0.9
Cardiovascular Disease	0.1	0.5	1.1	-0.4	-0.4	1.1	-0.3	0.9
Hair Pigment	0.1	2.7	6.4	-2.5	1.7	1.8	0.1	0.9
Relative age of first facial hair	0.1	0.2	0.4	0.5	-0.7	-0.3	-0.5	0.4
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.5	-0.6	-0.3	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.1	1.1	-0.6	-0.1	0.2	0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.4	-0.4	-0.1	0.6	0.0	0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.1	0.2	0.4	0.5	0.4
Impedance of leg (left)	0.1	0.7	1.6	-1.3	-0.7	-0.4	-0.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.3	-0.4	-0.2	0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.8	-0.6	-0.1	-0.5	-0.3
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.0	-0.0	0.6	-0.4	0.3
Allergy	0.1	0.3	0.8	0.5	0.2	-0.6	-0.3	-0.9
Impedance of arm (right)	0.1	0.6	1.3	-1.0	-1.1	-0.2	-0.4	-0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.1	0.5	0.1	0.5	-0.3
Depression (self-reported)	0.1	0.2	0.3	-0.1	-0.6	0.2	0.5	-0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.2	-0.4	-0.0	-0.2	-0.6
Birth weight	0.1	0.3	0.8	0.9	0.4	-0.0	-0.7	0.3
Age at last live birth	0.1	0.1	0.4	0.1	-0.2	0.2	0.1	0.6
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.4	0.5	0.2	0.6	0.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.8	0.6	0.3	-0.1	0.2
Mother’s age at death	0.1	0.2	0.5	0.7	-0.2	-0.5	-0.1	-0.1
Medication: Blood pressure	0.1	0.2	0.6	-0.0	0.4	0.7	0.8	-0.3
Medication: Paracetamol	0.1	0.2	0.8	0.2	0.1	0.9	0.2	-0.2
Heart disease (siblings)	0.1	0.2	0.6	-0.7	-0.3	0.2	-0.2	0.4
Alcohol drinker status: Previous	0.1	0.2	0.3	0.2	-0.4	0.6	0.5	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Respiratory disease	0.0	0.1	0.3	-0.6	-0.2	0.1	0.1	-0.2
Time employed in main current job	0.0	0.0	0.1	0.0	0.1	-0.3	0.1	0.1
Lung cancer (father)	0.0	0.0	0.1	-0.1	0.3	0.3	-0.0	-0.0
High blood pressure (siblings)	0.0	0.0	0.2	-0.4	0.1	0.2	-0.1	-0.0
Age at first live birth	0.0	0.1	0.2	-0.4	0.1	-0.2	-0.5	-0.1
Medication: Blood pressure	0.0	0.1	0.2	0.0	0.5	0.0	0.0	0.3

Hub : Genes

SEC14L5

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