TWAS hub - ANKS3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.3010	0.0910	0.00120	-0.004	NA	0.046	NA	-0.007	0.47000	NA	0.0130	NA	0.620
2	GTEx	Cells Transformed fibroblasts	0.0870	0.0370	0.00210	0.050	NA	0.029	NA	0.010	0.00013	NA	0.0027	NA	0.055
3	ROSMAP	Brain Pre-frontal Cortex	0.0787	0.0319	0.00067	-0.002	0.019	0.001	0.018	0.000	0.89000	0.0015	0.2200	0.0022	0.340

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication for cholesterol	9.1	13.8	19.0	-2.3	4.4	4.2
Medication: Blood pressure	7.9	15.1	19.3	2.6	-4.4	-4.4
Number of treatments/medications taken	7.7	13.9	18.4	3.0	-4.3	-3.8
Medication: Omeprazole	7.0	8.3	19.2	4.4	-1.6	-1.8
High blood pressure	6.3	17.5	22.6	2.9	-4.6	-4.8
Hypertension (Self-reported)	6.3	17.4	23.8	2.8	-4.5	-4.9
Systolic Blood Pressure	5.8	29.1	58.1	1.5	-5.2	-7.6
Vascular/heart problems diagnosed by doctor	5.8	15.9	21.2	-2.6	4.6	4.4
Body Mass Index (BMI) (2010)	5.2	7.1	13.1	-1.7	2.3	3.6
Pulse rate, automated reading	4.9	15.8	27.7	2.5	-5.3	-3.7
Medication: Omeprazole (e.g. Zanprol)	4.8	5.8	15.5	3.9	-1.0	-1.0
Number of self-reported non-cancer illnesses	4.6	8.0	8.7	2.7	-3.0	-2.8
Qualifications: nursing, teaching	4.5	7.0	8.8	-2.3	2.6	3.0
Pulse wave peak to peak time	4.4	5.2	7.7	-2.0	2.8	2.0
Medication: Bendroflumethiazide	4.4	6.6	11.1	0.5	-3.3	-2.9
Medication for pain relief, constipation, heartburn	4.3	7.4	11.9	-2.3	3.4	2.2
Diastolic blood pressure, automated reading	4.2	13.2	19.5	2.7	-4.4	-3.6
Prostate Cancer	4.1	5.7	7.9	-1.2	-2.8	-2.8
Cardiovascular Disease	4.0	13.1	19.3	1.1	-4.3	-4.4
Osteoarthritis (self-reported)	4.0	5.2	12.9	3.6	-1.2	-1.1
Systolic blood pressure, automated reading	3.8	11.0	16.1	2.6	-4.0	-3.2
Pulse wave Arterial Stiffness index	3.8	4.5	6.0	2.1	-2.4	-1.7
Medication: Amlodipine	3.8	5.4	8.0	2.6	-1.2	-2.8
Cholesterol lowering medication	3.6	5.3	8.7	3.0	-2.6	-0.8
Qualifications: O levels/GCSEs or equivalent	3.5	5.6	8.6	-1.0	2.9	2.7
Forced vital capacity (FVC), Best measure	3.4	12.3	21.9	-1.0	4.7	3.7
Medication: Lisinopril	3.3	4.2	5.9	1.2	-2.3	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.2	10.4	17.3	-1.3	4.2	3.5
Mouth/teeth dental problems: Mouth ulcers	3.2	5.0	9.4	3.1	-2.1	-1.1
Hip circumference	3.1	13.6	22.3	1.1	4.7	4.2
Chronotype (morning person)	3.0	6.9	13.6	2.0	-1.7	-3.7
Taking other prescription medications	3.0	4.6	9.1	3.0	-1.8	-1.1
Irritability	3.0	5.0	13.0	-0.7	-1.3	-3.6
Ever had prostate specific antigen (PSA) test	3.0	3.5	5.5	-0.7	2.3	2.1
Pain experienced in last month	2.9	4.8	7.9	-2.8	1.4	2.1
Hand grip strength (left)	2.8	7.5	10.0	-1.8	3.0	3.2
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.6	6.1	0.6	-2.5	-2.1
Number of operations (self-reported)	2.8	4.2	10.7	3.3	-1.1	-0.7
Schizophrenia vs Biploar Disorder	2.7	3.6	5.2	-1.6	2.3	1.7
Blood Platelet Count	2.7	31.9	42.2	-4.6	-6.5	-5.7
Medication: Co-codamol	2.7	3.2	5.2	0.3	2.1	2.3
Forced vital capacity (FVC)	2.7	10.3	18.1	-1.0	4.3	3.4
Hair/balding pattern: Pattern 4	2.7	6.5	11.7	-1.3	2.4	3.4
Trunk fat mass	2.6	11.0	19.4	-0.2	4.4	3.7
Qualifications: None of the above	2.6	5.5	9.0	0.4	-2.7	-3.0
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	14.4	-1.5	3.8	3.1
Ever taken oral contraceptive pill	2.6	2.9	5.5	-1.1	-1.4	-2.3
Happiness	2.5	3.0	8.4	-2.9	-0.7	0.4
Asthma	2.5	5.0	6.2	2.5	-2.4	-1.7
Medication: Seretide 50 evohaler	2.5	2.8	7.2	0.4	-1.1	-2.7
Long-standing illness, disability or infirmity	2.4	3.6	8.1	2.8	-1.2	-1.2
Asthma (self-reported)	2.4	4.8	6.2	2.5	-2.4	-1.6
Waist circumference	2.3	8.4	14.4	1.3	3.0	3.8
Medication: Ibuprofen	2.3	2.8	5.0	1.0	-2.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	8.2	-0.5	0.2	2.9
Basal cell carcinoma (self-reported)	2.3	2.7	4.6	1.6	-2.1	-1.0
Pack years of smoking	2.3	3.4	8.6	0.8	1.0	2.9
Fasting Glucose	2.2	2.7	4.6	1.8	-2.1	0.5
Weight	2.2	10.9	16.6	1.0	4.1	3.9
Pulse rate	2.2	3.7	6.2	0.7	-2.5	-2.1
Neck or shoulder pain in last month	2.2	3.2	9.4	3.1	-0.1	-0.4
Heart attack/myocardial infarction (self-reported)	2.2	2.8	5.0	1.8	-2.2	0.4
Trunk fat percentage	2.1	8.5	15.2	-0.5	3.9	3.1
Heart attack	2.1	2.7	4.8	1.8	-2.2	0.4
Pain all over the body in last month	2.1	2.2	5.0	-0.1	-2.2	-1.2
Hayfever/allergic rhinitis (self-reported)	2.1	2.7	5.0	-0.0	-1.8	-2.2
Noisy workplace	2.1	2.5	3.9	1.4	-1.4	-2.0
Qualifications: A levels/AS levels or equivalent	2.1	4.7	7.5	-0.1	2.6	2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	7.1	1.2	-1.0	-2.7
Health satisfaction	2.1	2.8	7.7	-2.8	-0.8	-0.2
Mean time to correctly identify matches	2.1	4.1	10.6	-3.3	-1.3	-0.1
Whole body fat mass	2.1	8.8	14.7	0.1	3.8	3.4
Mouth/teeth dental problems	1.9	3.0	8.2	-2.9	0.8	0.3
Pulse wave reflection index	1.9	2.3	3.7	1.9	-1.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	4.4	1.2	-1.2	-2.1
Supplements: Vitamin C	1.9	2.3	3.0	1.3	-1.7	-1.4
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.4	-0.4	-2.5	-0.3
Medication: Atorvastatin	1.9	2.3	3.1	1.3	-1.8	-1.5
Medication: Blood pressure	1.8	3.2	6.2	1.5	-1.1	-2.5
Had major operations	1.8	2.1	5.4	0.7	0.6	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	8.8	-0.1	3.0	1.6
Arm fat mass (left)	1.8	7.5	11.8	0.4	3.4	3.2
Crohns Disease (2017)	1.7	3.7	7.1	-0.4	2.7	2.0
Hair/balding pattern: Pattern 2	1.7	2.2	5.0	2.2	0.9	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	5.2	2.3	-0.7	0.5
Commuting to job workplace: Walk	1.7	1.9	4.6	1.0	-0.1	2.1
Medication: Gliclazide	1.7	1.9	5.3	2.3	0.5	-0.5
Height	1.6	30.1	51.1	0.8	7.2	6.2
Pack years adult smoking proportion	1.6	2.4	6.1	0.5	1.0	2.5
Medication: Simvastatin	1.6	2.4	5.1	2.3	-1.4	0.2
Arm fat percentage (right)	1.6	6.2	9.6	-0.3	3.1	3.0
Arm fat mass (right)	1.6	6.7	10.5	0.5	3.2	3.1
Standing height	1.6	15.9	26.8	0.2	5.2	4.6
Chronic bronchitis/emphysema (mother)	1.6	1.9	2.6	1.5	-1.6	-1.0
Body fat percentage	1.6	6.5	11.2	-0.3	3.3	2.9
Comparative height size at age 10	1.6	8.7	16.4	0.2	4.0	3.1
Overall health rating	1.6	3.4	6.5	1.5	-2.5	-1.2
Knee pain experienced in last month	1.6	2.4	5.8	2.4	-0.3	-1.2
Arm fat percentage (left)	1.6	6.2	10.4	-0.5	3.2	2.9
Mineral and other dietary supplements	1.6	2.1	4.7	-0.3	2.2	1.2
Major Depression (MDD)	1.5	1.8	3.3	-1.1	1.8	0.8
Reaction Time	1.5	2.9	7.2	-2.7	-0.9	-0.8
Smoking Status	1.5	3.6	8.3	0.2	-2.9	-1.6
Maternal smoking around birth	1.5	2.2	3.0	1.6	-1.7	-1.0
Qualifications: CSEs or equivalent	1.5	1.9	4.3	2.1	-1.1	-0.5
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	6.8	0.3	-2.6	-1.5
High blood pressure (siblings)	1.5	2.1	3.8	0.2	-1.9	-1.6
Illnesses of father: None of the above (group 1)	1.5	1.9	4.0	-2.0	-0.8	1.0
Basal metabolic rate	1.5	8.5	13.0	1.1	3.6	3.3
BMI	1.4	8.1	10.2	2.3	3.0	3.2
Vitamin and mineral supplements	1.4	1.9	3.5	0.4	1.9	1.4
Leg fat-free mass (left)	1.4	7.4	11.9	0.4	3.5	3.2
Had menopause	1.4	1.7	3.2	1.8	-1.4	-0.1
Falls in the last year	1.4	1.9	2.8	1.7	-1.6	-0.5
Loud music exposure frequency	1.4	1.5	4.4	0.3	-0.3	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.8	1.1	-1.9	-0.2
Leg fat-free mass (right)	1.4	7.2	11.0	0.3	3.3	3.3
Leg predicted mass (right)	1.4	7.2	11.1	0.3	3.3	3.2
Leg predicted mass (left)	1.3	7.1	11.4	0.4	3.4	3.1
Peak expiratory flow (PEF)	1.3	3.0	4.9	-0.8	1.8	2.2
Wheeze or whistling in the chest in last year	1.3	2.3	4.5	2.1	-1.2	-0.9
Whole body fat-free mass	1.3	7.2	10.2	1.3	3.2	3.1
Age started oral contraceptive pill	1.3	1.6	3.2	0.1	-1.8	-1.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	3.3	0.7	0.8	1.8
Sitting height	1.2	8.4	13.9	1.1	3.7	3.2
Trunk fat-free mass	1.2	6.7	8.6	1.7	2.9	2.9
Hair/balding pattern: Pattern 3	1.2	1.8	2.7	-1.6	0.6	-1.6
Trunk predicted mass	1.2	6.7	8.8	1.7	2.9	3.0
Angina (self-reported)	1.2	1.5	3.0	1.7	-1.1	-0.6
Leg fat mass (right)	1.2	4.5	6.5	0.9	2.5	2.5
Whole body water mass	1.2	6.8	9.4	1.4	3.1	3.0
Medication: Paracetamol	1.2	1.9	3.7	1.9	-1.2	-0.7
Unable to work because of sickness or disability	1.2	1.5	2.0	1.1	-1.1	-1.4
Leg fat mass (left)	1.2	4.7	6.8	0.9	2.5	2.6
Verbal and Numeric Reasoning (VNR)	1.1	2.6	5.2	0.7	1.4	2.3
Ulcerative Colitis	1.1	1.6	3.8	1.9	1.1	0.0
Respiratory disease	1.1	2.4	3.4	1.7	-1.8	-0.9
Lung FVC	1.1	5.8	7.9	-1.3	2.8	2.8
Hearing difficulty/problems: Yes	1.1	1.7	3.4	0.1	-1.3	-1.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.0	0.6	-1.4	-1.4
Angina	1.1	1.4	2.6	1.6	-1.1	-0.6
Hand grip strength (right)	1.1	3.0	4.4	-1.0	1.9	2.1
Medication: Levothyroxine sodium	1.1	1.9	4.4	0.9	-2.1	-0.8
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.6	-0.3	0.4	-1.9
Medication: Ramipril	1.1	1.5	2.4	1.5	0.1	-1.4
Time employed in main current job	1.1	1.3	2.3	1.5	0.9	0.8
Father’s age at death	1.1	1.4	3.6	-1.9	-0.8	-0.2
Medication: Lansoprazole	1.1	1.2	3.5	1.9	0.4	-0.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.2	0.3	0.8	1.8
Medication: Allopurinol	1.1	1.5	2.3	1.5	-1.5	-0.1
Arm predicted mass (right)	1.1	5.4	8.0	1.5	2.8	2.5
Alcohol intake frequency.	1.1	2.6	5.8	-1.0	2.4	1.1
Medication: Aspirin	1.1	1.4	2.9	0.8	-1.7	-0.8
Mood swings	1.1	2.0	3.9	-1.3	0.6	-2.0
Breast cancer (self-reported)	1.1	1.4	2.7	0.1	-1.6	-1.2
Smoking status: Current	1.1	1.8	3.5	0.3	-1.9	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.2	0.4	1.6	2.0
Arm fat-free mass (left)	1.1	5.8	7.0	1.9	2.6	2.6
Arm predicted mass (left)	1.1	5.5	7.2	1.9	2.4	2.7
Impedance of arm (left)	1.0	4.8	7.5	-2.7	2.3	1.4
Birth weight of first child	1.0	1.8	3.7	-0.7	1.1	1.9
Medication: Paracetamol	1.0	1.6	2.2	1.3	-1.5	-1.0
Glaucoma (self-reported)	1.0	1.2	2.7	-1.6	-0.7	0.7
Arm fat-free mass (right)	1.0	5.2	7.0	1.8	2.6	2.3
Family relationship satisfaction	1.0	1.2	2.4	-1.5	-0.9	-0.5
Diabetes diagnosed by doctor	1.0	1.7	4.4	2.1	-0.7	-0.3
Miserableness	1.0	1.7	2.6	-0.8	-1.4	-1.6
Financial situation satisfaction	1.0	1.2	2.1	-1.0	-1.4	0.7
Depressed Affect (Nagel 2018)	0.9	1.9	4.0	-2.0	0.1	-1.3
Irritable Bowel Disease (IBD)	0.9	2.2	3.8	0.4	2.0	1.6
Hypothyroidism (self reported)	0.9	2.0	4.3	0.7	-2.1	-1.0
Ever had hysterectomy (womb removed)	0.9	1.0	2.6	0.5	-0.4	1.6
Current tobacco smoking	0.9	1.4	2.6	0.5	-1.6	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.9	-1.7	-0.5	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.3	-1.3	2.1	-0.1
Medication: Atenolol	0.9	1.1	2.5	0.1	-0.9	-1.6
Impedance of arm (right)	0.9	4.1	6.6	-2.6	2.0	1.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.4	-0.9	1.1	1.6
Exposure to tobacco smoke outside home	0.9	1.2	3.0	-1.7	0.5	0.6
Qualifications: College or University degree	0.9	2.9	4.1	-1.1	1.8	2.0
Eye problems/disorders: Glaucoma	0.9	1.0	2.4	-1.5	-0.7	0.4
Alcohol drinker status: Previous	0.9	1.0	2.5	-0.4	1.6	-0.5
Intelligence (Savage-Jansen 2018)	0.8	2.5	4.9	0.7	1.5	2.2
HDL Cholesterol	0.8	1.3	2.5	-1.1	-0.4	-1.6
Blood Red Count	0.8	7.8	16.6	-0.8	4.1	2.4
Medication: Metformin	0.8	1.1	3.2	1.8	0.1	-0.3
Average weekly fortified wine intake	0.8	0.9	1.7	-1.3	-0.9	0.5
Stomach or abdominal pain in last month	0.8	1.0	1.8	1.1	-0.1	-1.3
Supplements: Glucosamine	0.8	1.0	1.6	1.3	-1.1	0.2
Alcohol usually taken with meals	0.8	1.3	2.4	0.0	1.2	1.6
Hearing difficulty/problems with background noise	0.8	1.2	2.4	-0.5	-1.0	-1.6
Allergy	0.8	1.8	2.3	-1.5	1.1	1.4
Breastfed as a baby	0.8	1.0	1.7	0.9	-0.6	1.3
Worry too long after embarrassment	0.8	1.3	3.2	-0.6	-0.7	-1.8
Number of full sisters	0.8	0.9	1.8	1.3	-1.0	0.3
High cholesterol (Self-reported)	0.8	1.4	3.7	-0.2	-1.9	-0.7
Ever smoked	0.8	1.4	2.2	1.4	-1.5	-0.0
Risk taking	0.8	1.2	2.2	0.8	-0.9	-1.5
Commuting to job workplace: Cycle	0.8	0.9	1.5	-0.8	0.8	1.2
Alzheimer’s Disease (in father)	0.7	0.8	1.9	0.4	1.4	0.5
Rheumatoid Arthritis	0.7	1.0	2.9	0.4	1.7	-0.1
Schizophrenia (2014)	0.7	1.7	2.6	-1.2	0.9	1.6
Blood White Count	0.7	5.1	11.9	-1.0	-3.5	-1.5
Relative age of first facial hair	0.7	1.4	3.5	-0.4	-0.8	-1.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	1.2	0.8	0.6
Medication for hormone replacement therapy	0.7	0.8	1.2	-0.4	-1.1	-1.1
Diabetes (father)	0.7	0.9	2.2	1.5	-0.5	-0.2
Severe depression (siblings)	0.7	0.8	1.4	0.3	0.9	-1.2
Chronic bronchitis/emphysema (father)	0.7	0.9	1.2	1.0	0.6	1.1
Body mass index (BMI)	0.7	2.8	3.9	1.2	1.8	2.0
Past tobacco smoking	0.7	1.4	3.0	-1.0	1.7	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.8	-0.9	-0.7	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	-0.3	0.7	1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.3	1.1	0.2	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.4	-1.2	-0.5	-1.0
Shortness of breath walking on level ground	0.7	0.8	1.3	1.0	-1.1	-0.4
Illnesses of siblings: Diabetes	0.7	0.8	1.2	-1.1	0.8	0.7
Ever had bowel cancer screening	0.7	0.9	1.4	1.2	-0.4	1.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.3	-0.3	-1.1	-1.1
Heart disease (siblings)	0.7	0.8	2.1	0.6	0.3	-1.4
Schizophrenia (2018)	0.6	1.1	1.5	-0.8	1.1	1.2
Alzheimer’s Disease (including proxy)	0.6	0.8	2.2	-0.4	-0.2	-1.5
Ovarian Cancer	0.6	0.8	2.0	-0.4	-1.4	-0.5
Coronary Artery Disease (CAD)	0.6	0.7	1.0	-1.0	0.7	0.8
LDL Cholesterol	0.6	0.9	1.3	-0.3	1.1	1.1
Lupus	0.6	0.9	1.5	0.8	-1.2	-0.7
Alcohol intake versus 10 years previously	0.6	0.9	2.6	0.3	-0.2	-1.6
Length of working week for main job	0.6	0.7	1.9	-1.4	0.1	-0.5
Headache pain in last month	0.6	1.1	1.7	1.3	1.3	0.3
Gout (self-reported)	0.6	0.9	2.5	1.6	-0.3	0.3
Leg fat percentage (right)	0.6	2.1	3.4	0.9	1.5	1.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.0	-1.0	1.0	0.5
Leg fat percentage (left)	0.6	2.3	3.5	0.9	1.6	1.9
Fractured/broken bones in last 5 years	0.6	0.7	1.6	0.7	0.2	1.3
Neuroticism (Nagel 2018)	0.5	1.1	2.3	-0.9	-0.3	-1.5
Age at First Birth	0.5	0.8	2.3	-1.5	0.3	-0.1
High blood pressure (mother)	0.5	0.8	2.1	0.2	-0.4	-1.4
Had other major operations	0.5	0.6	1.0	0.8	0.2	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.4	-1.1	1.0	-1.2
Diabetes (self-reported)	0.5	0.8	2.0	1.4	-0.6	0.0
Neuroticism score	0.5	1.1	1.9	-1.1	-0.3	-1.4
Depression (self-reported)	0.5	0.7	0.9	0.8	0.9	-0.7
Tense / ‘highly strung’	0.5	0.8	1.7	-1.3	-0.3	-0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.4	0.3	0.7	1.2
Comparative body size at age 10	0.5	1.3	1.9	-0.5	1.4	1.3
Back pain experienced in last month	0.5	0.7	1.2	1.1	-0.1	1.0
Medication: Aspirin	0.5	0.6	1.5	0.2	-1.2	-0.5
Mother’s age at death	0.5	0.7	1.5	-0.6	0.3	1.2
Depression (Nagel 2018)	0.4	0.5	1.6	-1.2	-0.2	0.0
Alzheimer’s Disease (in mother)	0.4	0.5	1.4	-1.2	-0.2	-0.1
Mean Putamen Volume	0.4	0.4	0.7	0.8	-0.7	-0.3
Triglycerides	0.4	0.6	0.8	0.9	0.6	0.7
Neuroticism	0.4	1.0	2.5	-1.6	-0.4	-0.7
Hair Pigment	0.4	11.8	15.0	3.1	-3.3	-3.9
Fed-up feelings	0.4	0.6	1.1	-1.0	-0.8	-0.5
Nervous feelings	0.4	0.8	1.1	1.0	1.0	-0.5
Mouth/teeth dental problems: Dentures	0.4	0.6	1.0	0.9	1.0	0.3
Medication: Cholesterol lowering	0.4	0.6	0.8	0.5	-0.9	-0.8
Exposure to tobacco smoke at home	0.4	0.5	1.4	-0.0	-1.2	-0.3
Blood clot in the leg (DVT)	0.4	0.5	1.3	-0.2	1.1	-0.4
Number of full brothers	0.4	0.5	1.2	1.1	-0.4	-0.5
Eye problems/disorders: None of the above	0.4	0.5	0.8	0.9	0.2	-0.8
Emphysema/chronic bronchitis	0.4	0.5	0.7	0.8	-0.5	-0.7
Migraine (self-reported)	0.4	0.5	1.0	1.0	-0.5	-0.4
Heart disease (mother)	0.4	0.5	0.9	-0.9	0.4	-0.7
Leg pain on walking	0.4	0.5	1.3	0.2	-1.2	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	-1.1	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	0.3	-1.1	-0.1
Myopia	0.4	0.6	1.2	0.8	-1.1	0.3
Supplements: Calcium	0.4	0.4	0.7	-0.2	-0.8	0.8
Lung FEV1/FVC ratio	0.3	1.3	2.2	1.5	-1.3	-0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.7	0.1	-0.8
Relative age voice broke	0.3	0.4	1.2	0.0	0.0	-1.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.4	0.3	0.7	0.6
Multivitamins +/- minerals	0.3	0.3	0.5	-0.5	-0.7	-0.5
Number of incorrect matches in round	0.3	0.5	0.6	0.4	0.8	-0.8
Fluid intelligence score	0.3	0.6	0.9	0.8	0.7	1.0
Worrier / anxious feelings	0.3	0.5	1.4	0.4	-0.1	-1.2
Prospective memory result	0.3	0.3	0.4	-0.7	-0.5	0.6
Illnesses of mother	0.3	0.4	0.6	0.6	0.2	0.8
Age at first live birth	0.3	0.6	1.5	-0.4	0.4	1.2
Age at last live birth	0.3	0.4	1.2	-1.1	-0.3	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.7	-0.3	-0.7
Smoking status: Previous	0.3	0.5	1.0	0.5	-1.0	0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	-0.2	0.7	-0.7
Eye problems/disorders: Cataract	0.3	0.4	1.1	0.0	-1.0	0.0
Osteoporosis (self-reported)	0.3	0.4	0.5	0.7	-0.5	0.7
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.6	-0.5	-0.7
Guilty feelings	0.3	0.4	0.7	-0.6	-0.9	-0.3
Wears glasses or contact lenses	0.3	0.4	0.5	0.7	-0.6	0.5
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.3	-0.5	0.8
Illnesses of father: High blood pressure	0.3	0.4	1.0	-0.1	-0.3	-1.0
Ever depressed for a whole week	0.3	0.4	1.2	-0.1	1.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	0.2	1.0	-0.3
Impedance of whole body	0.3	1.8	3.5	-1.9	1.2	0.4
Ulcerative Colitis (UC)	0.2	0.3	0.7	0.8	0.5	0.3
Crohns Disease (2012)	0.2	0.4	0.6	-0.7	0.8	0.1
HbA1C	0.2	0.2	0.5	-0.2	-0.1	0.7
Neuroticism (2016)	0.2	0.3	0.5	0.2	-0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.2	-0.2	-0.8
Waist Hip Ratio (WHR)	0.2	0.7	1.7	0.3	-1.3	0.5
Allergy or Eczema	0.2	0.5	1.1	1.0	0.1	-0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.0	1.0	-0.0	0.1
Average weekly spirits intake	0.2	0.2	0.3	-0.4	0.5	-0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.6	-0.7	0.3
Diabetes (mother)	0.2	0.2	0.7	-0.2	0.8	0.0
Age when periods started (menarche)	0.2	0.5	1.3	-0.0	-0.5	1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.7	0.0	0.3	0.8
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.1	-0.7	-0.3
Illnesses of siblings	0.2	0.3	0.6	-0.0	0.7	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	-0.2	0.8	0.4
Lung cancer (father)	0.2	0.3	0.6	0.3	0.4	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	-0.5	0.6	-0.2
Suffer from ‘nerves’	0.2	0.3	0.8	0.9	0.4	-0.0
Chest pain or discomfort	0.2	0.2	0.5	-0.2	-0.7	-0.4
Illnesses of father: Heart disease	0.2	0.3	0.5	0.1	0.7	-0.5
Average weekly red wine intake	0.2	0.3	0.3	0.6	-0.5	0.5
Loneliness, isolation	0.2	0.3	0.5	-0.6	-0.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	0.9	0.1	-0.1
Bipolar Disorder (2018)	0.1	0.1	0.3	0.5	-0.0	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.3	0.6	0.8
Worry (Nagel 2018)	0.1	0.3	0.7	0.3	0.8	0.2
Primary Biliary Cirrhosis	0.1	0.2	0.2	-0.4	-0.2	0.5
Blood Eosinophil Count	0.1	1.0	1.7	-0.9	-1.3	-0.7
Heel T-Score	0.1	1.2	2.1	-1.2	1.4	0.1
Tanning	0.1	0.7	0.9	-0.4	-0.9	1.0
Sensitivity / hurt feelings	0.1	0.2	0.3	0.2	-0.4	-0.6
Supplements: Zinc	0.1	0.1	0.2	0.2	-0.2	0.4
Impedance of leg (right)	0.1	0.4	1.0	-0.3	-0.2	-1.0
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.1	-0.3	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	0.8	0.3	-0.4
Impedance of leg (left)	0.1	0.3	0.7	-0.5	-0.0	-0.8
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.2	-0.5	0.2
Number of live births	0.1	0.1	0.3	0.3	0.0	0.6
Birth weight	0.1	0.2	0.5	0.7	0.2	0.3
Number of children fathered	0.1	0.1	0.2	0.3	-0.5	-0.3
Hearing aid user	0.1	0.1	0.3	-0.5	0.4	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.6	-0.1	-0.5
Breast Cancer	0.0	0.1	0.2	0.2	0.3	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Friendships satisfaction	0.0	0.0	0.1	-0.3	-0.2	0.1
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	-0.0	0.1

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