Hub : Genes

CBFA2T3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pancreas 0.5570 0.0650 1.5e-10 0.198 NA 0.257 NA 0.256 9.2e-09 NA 2.9e-11 NA 3.1e-11
2 YFS Blood 0.0154 0.0072 2.9e-03 -0.001 0.011 0.000 0.011 0.001 6.3e-01 0.00013 5.3e-01 0.00011 1.6e-01
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0377 0.0172 2.0e-03 0.044 0.024 0.027 NA 0.033 8.5e-06 0.00086 4.2e-04 NA 1.2e-04
4 TCGA Pancreatic Adenocarcinoma 0.0850 0.0420 5.0e-03 0.057 0.076 0.056 NA 0.050 2.0e-03 0.00042 2.3e-03 NA 3.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.7 2.6 0.6 -1.6 0.0 0.0
Bipolar Disorder or Schizophrenia 1.1 2.6 9.6 -1.0 -3.1 0.0 0.0
Depressed Affect (Nagel 2018) 3.5 7.3 12.4 -2.7 -0.6 -3.5 -3.0
Depression (Nagel 2018) 1.6 2.4 3.8 -1.7 -0.3 -1.7 -1.9
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.2 -0.4 0.4 -0.0 0.3
Neuroticism (Nagel 2018) 5.7 13.5 20.1 -3.8 -0.6 -4.4 -4.5
Schizophrenia (2018) 1.2 2.6 7.3 -1.4 -2.7 -1.0 0.0
Schizophrenia vs Biploar Disorder 0.2 0.2 1.0 0.0 -1.0 0.0 0.0
Worry (Nagel 2018) 3.1 6.5 11.9 -2.3 0.3 -3.0 -3.5
Alzheimer’s Disease (in mother) 1.2 1.4 2.3 0.9 1.5 0.6 1.5
Alzheimer’s Disease (in father) 0.4 0.4 1.6 0.0 -1.3 -0.1 0.4
Alzheimer’s Disease (including proxy) 0.1 0.2 0.5 0.1 0.5 0.3 0.7
Crohns Disease (2017) 0.1 0.2 0.7 0.3 0.3 -0.2 -0.8
Irritable Bowel Disease (IBD) 0.1 0.4 1.3 0.2 -0.1 -0.1 -1.1
Ulcerative Colitis (UC) 0.3 0.5 1.8 0.0 -0.3 -0.4 -1.4
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.6 3.1 7.1 -1.0 -2.7 -1.4 -1.4
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.7 -0.4 1.3 -0.1 0.3
Breast Cancer 1.2 3.0 5.3 1.4 1.3 2.3 1.6
Ovarian Cancer 1.2 1.6 4.4 1.2 0.3 2.1 0.8
Prostate Cancer 0.0 0.0 0.1 0.1 -0.1 -0.1 -0.3
Age at First Birth 1.3 1.8 3.2 -1.2 -0.3 -1.6 -1.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 2.1 -1.5 -0.1 -1.3 -1.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.0 0.0 0.0 0.0 -0.2 0.0 0.0
Mean Putamen Volume 0.9 1.0 2.1 -0.8 -0.7 -1.0 -1.4
Fasting Glucose 0.5 0.6 0.9 -0.9 -0.8 -1.0 -0.1
HbA1C 1.5 1.7 3.2 1.0 -1.8 1.6 0.4
HDL Cholesterol 2.5 4.2 5.1 1.9 2.1 1.9 2.3
LDL Cholesterol 0.6 1.0 1.8 0.9 -1.3 0.7 1.0
Lupus 0.3 0.4 1.1 1.1 0.0 0.5 0.7
Neuroticism (2016) 2.5 3.6 6.2 -2.5 -0.5 -1.9 -2.1
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.4 0.6 -0.7 0.3
Rheumatoid Arthritis 0.3 0.5 0.8 0.8 -0.9 0.3 0.6
Schizophrenia (2014) 0.9 2.0 6.8 -0.8 -2.6 -0.3 -0.7
Triglycerides 1.2 1.9 2.6 -1.6 -1.6 -1.3 -0.8
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.5 -0.0 0.0 0.0
Ulcerative Colitis 0.3 0.4 1.5 1.2 0.1 0.0 0.0
Blood Eosinophil Count 0.2 1.8 4.7 2.2 -1.1 0.5 1.0
Blood Platelet Count 1.6 18.0 28.0 -2.6 -3.3 -5.3 -5.2
Blood Red Count 4.7 45.7 55.8 6.4 6.0 7.0 7.5
Blood White Count 0.9 6.6 11.2 3.2 3.4 1.5 1.6
Heel T-Score 0.2 1.3 4.2 -0.1 2.1 -0.9 0.6
BMI 0.5 2.9 4.5 -1.7 -1.5 -1.4 -2.1
Height 1.9 36.6 60.1 6.0 2.6 7.8 6.6
Waist Hip Ratio (WHR) 0.6 2.6 5.6 -1.6 -0.8 -1.3 -2.4
Systolic Blood Pressure 1.8 9.2 14.0 -2.8 -1.5 -3.7 -3.6
Smoking Status 0.3 0.6 1.9 -0.8 -1.4 -0.2 -0.0
Allergy or Eczema 0.6 1.5 3.8 -0.1 -1.9 -0.5 -1.4
Cardiovascular Disease 2.8 9.3 12.5 -3.0 -2.7 -2.9 -3.5
Hypothyroidism (self reported) 0.1 0.2 0.9 0.2 0.1 0.1 1.0
Respiratory disease 4.4 9.9 16.7 -2.2 -2.6 -3.3 -4.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.6 -0.8 -0.5 -0.7 -0.8
Lung FEV1/FVC ratio 0.7 3.6 5.5 1.5 1.6 2.3 2.0
Lung FVC 1.4 7.2 15.3 1.2 3.9 2.0 2.8
Neuroticism 6.7 16.2 23.8 -3.9 -1.9 -4.7 -4.9
Chronotype (morning person) 0.6 1.3 2.2 1.2 0.1 1.5 1.3
Hair Pigment 19.6 558.2 806.6 -28.3 -14.6 -20.3 -28.4
Tanning 14.2 173.7 285.6 16.9 3.7 12.6 15.4
Hand grip strength (left) 0.7 1.8 6.5 -0.4 2.5 0.1 0.7
Number of treatments/medications taken 4.1 7.4 11.8 -2.2 -3.4 -1.7 -3.2
Average weekly spirits intake 3.0 3.8 5.7 -2.2 0.3 -2.4 -2.1
Sensitivity / hurt feelings 5.1 8.7 14.3 -3.2 -0.1 -3.2 -3.8
Frequency of depressed mood in last 2 weeks 2.7 3.8 6.7 -1.8 -0.5 -2.2 -2.6
Hearing difficulty/problems: Yes 3.9 6.0 7.7 -2.8 -2.0 -2.3 -2.7
Relative age of first facial hair 0.3 0.5 1.0 -1.0 0.9 0.5 0.0
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 3.0 -1.2 -1.2 -1.6 -1.7
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.1 0.4 -0.3 -0.3 -0.1
Ever had hysterectomy (womb removed) 1.5 1.7 3.1 1.8 -0.9 1.7 0.2
Systolic blood pressure, automated reading 0.0 0.1 0.3 0.3 -0.4 -0.1 -0.5
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.4 0.9 0.3 0.4 1.5
Angina 1.0 1.3 2.3 -1.5 -0.9 -0.9 -1.1
Medication for hormone replacement therapy 1.7 1.9 4.3 1.3 -0.5 1.2 2.1
Vitamin and mineral supplements 0.3 0.4 1.3 0.4 1.1 -0.3 0.1
Supplements: Zinc 0.3 0.3 0.6 -0.3 -0.4 -0.6 -0.8
Medication: Co-codamol 1.1 1.2 2.0 -1.1 -0.3 -1.3 -1.4
Medication: Metformin 0.7 1.0 1.5 1.0 -0.0 1.2 1.1
Diabetes (father) 1.6 2.0 3.3 -0.7 -1.2 -1.6 -1.8
Diabetes (mother) 0.5 0.6 1.5 -0.6 -1.2 -0.6 -0.3
Severe depression (siblings) 3.3 3.7 6.1 -2.1 -0.3 -2.1 -2.5
Pack years adult smoking proportion 0.6 0.9 2.9 -0.6 -1.7 0.1 -0.6
Impedance of leg (right) 0.6 3.0 6.8 2.2 -2.6 0.2 0.6
Leg fat-free mass (left) 0.3 1.6 3.4 -0.3 1.6 1.8 0.3
Trunk fat percentage 1.5 6.0 10.6 2.8 -1.2 3.3 2.1
Hand grip strength (right) 1.1 3.1 11.4 -0.1 3.4 0.2 1.0
Townsend deprivation index at recruitment 0.7 0.9 1.9 0.6 -0.4 1.4 1.2
Current tobacco smoking 1.4 2.3 3.0 -1.6 -1.3 -1.4 -1.7
Average weekly fortified wine intake 3.8 4.4 9.1 -2.0 -0.3 -2.2 -3.0
Maternal smoking around birth 3.3 4.7 7.7 2.3 1.0 2.1 2.8
Fed-up feelings 5.8 10.5 15.0 -3.9 -0.5 -3.7 -3.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 2.0 -0.8 -0.5 -1.0 -1.4
Relative age voice broke 0.3 0.5 1.4 -1.2 0.7 -0.1 0.1
Taking other prescription medications 3.0 4.6 6.6 -2.0 -2.6 -1.7 -2.2
Age when periods started (menarche) 0.9 2.1 4.2 0.1 2.1 1.4 1.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.7 -0.1 -0.1 -0.1 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.8 0.5 0.3 0.9 0.0
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 1.9 1.1 1.2 1.2 1.4
Qualifications: CSEs or equivalent 0.4 0.5 1.7 -0.5 1.3 -0.0 -0.1
Serious illness, injury or assault to yourself 0.5 0.6 1.9 -0.3 0.4 -1.4 -0.4
High blood pressure 1.9 5.4 11.2 -2.1 -1.7 -1.7 -3.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.0 -0.5 -1.4 -0.6 -0.9
Multivitamins +/- minerals 1.0 1.2 3.0 -1.1 -1.7 -0.6 -0.7
Stomach or abdominal pain in last month 1.3 1.7 4.0 -0.7 -2.0 -0.5 -1.4
Supplements: Glucosamine 2.4 3.1 6.3 1.9 0.3 2.5 1.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 0.5 0.5 0.1 0.3
Medication: Atenolol 1.3 1.6 4.1 -1.2 0.5 -0.8 -2.0
Medication: Levothyroxine sodium 0.1 0.2 0.3 -0.3 -0.5 0.1 0.5
Sitting height 3.0 21.6 36.0 4.3 3.8 6.0 4.2
Chronic bronchitis/emphysema (father) 0.3 0.4 0.6 0.7 0.2 0.7 0.8
High blood pressure (mother) 0.7 0.9 2.1 -1.1 0.2 -0.7 -1.4
Body mass index (BMI) 0.2 1.0 1.6 -1.0 -1.2 0.0 -1.3
Impedance of leg (left) 0.7 3.3 6.9 2.3 -2.6 0.4 1.0
Leg predicted mass (left) 0.3 1.7 4.0 -0.1 1.7 2.0 0.4
Trunk fat mass 1.0 4.3 10.2 2.0 -0.9 3.2 1.5
Waist circumference 0.5 1.7 3.6 -0.6 -1.9 0.7 -1.5
Number of incorrect matches in round 1.6 2.6 4.5 2.1 -1.3 1.3 1.6
Past tobacco smoking 2.6 4.7 8.9 -1.9 -1.0 -2.3 -3.0
Alcohol usually taken with meals 0.5 0.8 1.6 -0.8 1.1 -1.2 -0.2
Nervous feelings 1.2 2.3 4.1 -0.9 -0.5 -2.0 -2.0
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 3.8 -1.5 0.5 -1.7 -2.0
Hearing difficulty/problems with background noise 2.5 4.1 7.1 -2.5 -0.7 -1.5 -2.7
Hair/balding pattern: Pattern 2 0.1 0.2 0.5 -0.1 0.4 0.7 0.0
Had menopause 1.9 2.4 4.1 1.7 0.5 2.0 1.6
Had other major operations 1.1 1.4 2.4 -0.6 -1.6 -1.2 -1.1
Forced vital capacity (FVC) 2.7 10.5 20.0 2.2 4.5 2.8 3.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 1.4 1.2 0.9 1.0 0.4
Ever unenthusiastic/disinterested for a whole week 2.9 3.5 5.8 -1.7 0.6 -2.4 -2.3
Qualifications: None of the above 0.3 0.6 1.1 -0.7 -0.1 -0.9 -1.0
Financial difficulties in last 2 years 1.1 1.4 2.6 -0.7 -0.3 -1.6 -1.6
Mouth/teeth dental problems 2.1 3.2 7.1 1.3 0.8 1.9 2.7
Heart attack 0.3 0.4 0.8 0.1 -0.9 -0.4 -0.8
Allergy 2.4 5.5 7.6 1.7 2.2 2.6 2.8
Pain all over the body in last month 0.5 0.5 0.8 0.8 -0.6 -0.4 -0.9
Diabetes (self-reported) 0.6 0.9 2.5 -1.6 -0.7 -0.4 -0.8
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 4.5 -1.1 -2.1 -0.7 -0.6
Medication: Ramipril 4.1 5.3 8.5 -2.9 -1.4 -2.4 -2.2
Medication: Simvastatin 1.5 2.2 2.6 -1.6 -1.4 -1.3 -1.5
Fluid intelligence score 0.2 0.5 1.4 0.3 1.2 0.1 0.6
Illnesses of siblings 1.3 1.8 3.3 1.3 -0.4 1.4 1.8
Neuroticism score 8.7 18.2 26.6 -4.4 -1.5 -4.9 -5.2
Weight 0.4 1.8 6.3 0.7 -0.3 2.5 0.6
Impedance of arm (right) 2.3 10.5 19.1 4.4 0.2 3.3 3.5
Arm fat percentage (right) 0.6 2.2 5.0 1.3 -1.2 2.2 0.8
Trunk fat-free mass 0.2 1.0 1.6 -1.2 0.7 1.3 -0.7
Hip circumference 0.3 1.3 4.0 0.7 -0.6 2.0 0.6
Time employed in main current job 1.0 1.2 1.9 -1.4 -0.9 -1.2 -0.7
Alcohol intake versus 10 years previously 3.9 5.9 8.9 -2.0 -3.0 -2.7 -1.9
Father’s age at death 0.2 0.2 0.3 -0.6 -0.5 0.4 0.4
Worrier / anxious feelings 3.9 7.4 11.0 -2.8 -0.1 -3.3 -3.3
Frequency of tiredness / lethargy in last 2 weeks 9.6 15.5 24.7 -4.0 -2.5 -3.9 -5.0
Falls in the last year 0.5 0.7 2.7 0.1 -1.7 -0.1 -0.3
Hair/balding pattern: Pattern 3 0.5 0.8 1.2 -1.1 -0.1 -1.1 -0.8
Number of live births 0.3 0.4 1.0 -0.3 1.0 0.7 0.3
Forced expiratory volume in 1-second (FEV1) 3.9 13.1 21.4 2.4 4.6 3.3 3.8
Pulse rate 1.8 3.0 5.9 -0.8 -0.7 -2.4 -2.2
Happiness 0.8 0.9 1.7 1.3 -1.2 0.6 -0.4
Noisy workplace 0.7 0.9 2.4 -1.5 -0.8 -0.7 -0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.3 1.0 -0.4 1.0 0.3 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 1.8 -1.3 -0.3 -1.3 -1.2
Mouth/teeth dental problems: Dentures 0.3 0.6 1.6 -0.4 0.5 -0.5 -1.3
Asthma 3.0 6.0 9.9 -1.4 -1.9 -2.9 -3.1
Medication: Ibuprofen (e.g. Nurofen) 5.9 7.5 10.5 -3.1 -1.5 -2.7 -3.2
Medication: Cholesterol lowering 0.6 0.9 2.6 -0.8 -1.6 -0.1 -0.5
Depression (self-reported) 0.2 0.3 0.6 -0.5 -0.3 -0.5 -0.8
Medication: Lansoprazole 0.9 1.0 2.7 0.5 -1.6 1.0 -0.4
Prospective memory result 0.1 0.1 0.4 0.1 -0.6 0.1 -0.3
Lung cancer (father) 1.0 1.1 3.0 -1.7 0.1 -1.2 -0.4
Illnesses of mother 0.0 0.0 0.0 -0.2 -0.1 -0.0 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 4.6 14.8 18.5 3.0 4.1 3.8 4.3
Pulse wave Arterial Stiffness index 0.4 0.5 1.1 1.0 -0.8 0.5 -0.2
Impedance of arm (left) 2.9 13.6 23.4 4.8 1.3 3.4 4.2
Arm fat mass (right) 0.3 1.0 3.0 0.4 -1.0 1.7 0.1
Trunk predicted mass 0.2 1.1 1.6 -1.2 0.7 1.3 -0.8
Standing height 1.7 17.1 31.6 3.8 2.0 5.6 4.2
Length of working week for main job 0.6 0.6 1.4 0.5 -0.5 0.8 1.2
Exposure to tobacco smoke at home 0.9 1.0 2.5 1.6 0.6 0.7 0.8
Breastfed as a baby 1.2 1.5 3.3 0.9 -0.0 1.4 1.8
Tense / ‘highly strung’ 1.7 2.8 6.5 -0.9 1.2 -1.6 -2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 0.8 0.2 -0.9 0.3 -0.8
Hair/balding pattern: Pattern 4 0.5 1.3 2.6 1.0 1.6 1.0 0.8
Birth weight of first child 0.9 1.6 3.2 -1.4 -0.8 -0.9 -1.8
Peak expiratory flow (PEF) 2.5 5.8 19.5 0.5 4.4 1.0 1.6
Pulse wave reflection index 0.6 0.8 1.5 0.6 1.2 0.9 0.5
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.0 0.2 1.0 0.3 -0.2
Loud music exposure frequency 3.2 3.5 5.0 -2.1 -2.2 -1.1 -1.8
Qualifications: O levels/GCSEs or equivalent 0.0 0.1 0.2 -0.2 -0.4 -0.2 0.2
Mouth/teeth dental problems: Bleeding gums 1.3 1.6 3.8 -1.0 -0.8 -1.1 -1.9
Blood clot in the leg (DVT) 1.1 1.4 2.3 -1.5 1.2 -0.9 -0.9
Medication: Paracetamol 1.6 2.6 6.3 -1.3 -1.3 -0.9 -2.5
Headache pain in last month 3.0 5.2 8.4 -2.6 -1.2 -1.9 -2.9
Medication for cholesterol, blood pressure or diabetes 2.1 3.5 4.8 2.0 2.2 1.1 1.9
Glaucoma (self-reported) 1.0 1.1 2.1 1.0 0.8 0.9 1.5
Gout (self-reported) 3.0 4.2 5.8 -1.8 -1.6 -2.3 -2.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.4 0.7 0.0 0.9 1.2
Medication: Amlodipine 1.6 2.2 4.1 -1.6 -1.0 -1.1 -2.0
Medication: Ventolin 100micrograms inhaler 3.3 4.2 7.1 -2.1 -0.5 -2.7 -2.3
Birth weight 0.1 0.1 0.4 0.3 0.3 -0.1 -0.6
Chronic bronchitis/emphysema (mother) 1.8 2.1 3.6 -1.3 -1.4 -1.9 -1.0
High blood pressure (siblings) 0.4 0.6 1.9 -0.3 0.6 0.3 -1.4
Forced vital capacity (FVC), Best measure 3.1 11.2 13.6 2.7 3.7 3.3 3.6
Body fat percentage 1.0 3.8 6.4 2.0 -1.7 2.5 1.3
Leg fat percentage (right) 0.7 2.6 9.0 0.4 -3.0 0.7 -0.8
Arm fat-free mass (right) 0.2 0.8 1.5 -1.2 0.5 0.7 -0.9
Exposure to tobacco smoke outside home 0.5 0.7 2.3 -1.5 -0.2 -0.5 -0.6
Comparative body size at age 10 0.4 1.0 1.5 0.9 1.1 0.7 1.2
Number of full brothers 1.0 1.2 3.6 0.3 -0.7 0.9 1.9
Worry too long after embarrassment 5.5 9.3 13.6 -3.7 -1.6 -3.3 -3.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.7 0.6 -0.8 0.6 -0.2
Wheeze or whistling in the chest in last year 7.5 13.4 19.8 -2.8 -2.9 -4.4 -4.2
Number of children fathered 0.2 0.2 0.5 -0.5 0.7 -0.1 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.2 0.2 -0.7 1.1 0.4
Age at first live birth 0.6 1.1 3.0 -1.1 0.3 -1.7 -0.5
Pulse wave peak to peak time 0.4 0.4 0.8 -0.7 0.9 0.0 0.5
Health satisfaction 1.2 1.6 3.6 1.9 -1.4 0.8 0.3
Shortness of breath walking on level ground 2.8 3.3 5.2 -1.9 -1.6 -1.4 -2.3
Qualifications: College or University degree 0.0 0.1 0.1 0.3 0.2 0.3 0.4
Eye problems/disorders: None of the above 0.7 0.9 3.0 -0.0 0.1 -0.6 -1.7
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 -0.2 -0.1 -0.5 -0.3
Emphysema/chronic bronchitis 0.9 1.0 1.7 0.6 -0.6 1.3 1.2
Medication for pain relief, constipation, heartburn 3.0 5.1 9.3 2.3 1.7 1.7 3.0
Neck or shoulder pain in last month 1.8 2.6 4.1 -2.0 -1.3 -1.3 -1.7
Medication: Blood pressure 4.9 8.6 14.7 -3.5 -1.2 -2.5 -3.8
Angina (self-reported) 1.0 1.3 2.4 -1.5 -1.2 -0.6 -1.0
Migraine (self-reported) 0.5 0.6 0.8 -0.9 -0.4 -0.8 -0.8
Medication: Ibuprofen 4.5 5.4 7.4 -2.7 -1.6 -2.1 -2.7
Medication: Allopurinol 2.7 3.7 4.4 -1.8 -1.6 -2.1 -2.1
Medication: Omeprazole 0.7 0.8 1.3 -1.1 -0.8 -0.9 -0.7
Medication: Seretide 50 evohaler 3.5 4.0 5.7 -2.4 -0.3 -2.2 -2.3
Mean time to correctly identify matches 0.9 1.7 5.4 -0.4 -2.3 -1.0 -0.6
Heart disease (mother) 1.8 2.2 2.8 1.7 1.5 1.5 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.0 -0.8 0.8 -0.9 -1.0
Whole body fat mass 0.5 2.1 5.4 1.0 -1.2 2.3 0.7
Leg fat mass (right) 0.3 1.3 3.4 0.1 -1.8 1.2 -0.5
Arm predicted mass (right) 0.2 0.8 1.7 -1.3 0.6 0.6 -0.9
Pulse rate, automated reading 2.3 7.4 12.2 -1.2 -2.1 -3.4 -3.5
Alcohol intake frequency. 1.4 3.3 5.4 -1.5 -1.5 -1.9 -2.3
Comparative height size at age 10 1.1 6.2 9.1 2.9 1.4 3.0 2.3
Number of full sisters 1.0 1.2 2.1 -1.5 -1.4 -0.3 -0.8
Suffer from ‘nerves’ 1.4 2.1 3.2 -1.8 -0.1 -1.5 -1.7
Overall health rating 2.4 5.1 11.3 -1.3 -3.4 -1.4 -2.3
Chest pain or discomfort 3.2 4.6 9.4 -1.9 -0.8 -3.1 -2.2
Had major operations 0.7 0.8 1.7 0.8 0.3 1.0 1.3
Age at last live birth 1.5 2.2 4.3 -1.8 -0.4 -2.1 -0.9
Family relationship satisfaction 0.2 0.3 0.6 0.1 -0.8 -0.5 -0.3
Leg pain on walking 1.0 1.3 1.9 -1.3 -1.4 -0.4 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.9 0.1 1.4 0.2 0.4
Commuting to job workplace: Car/motor vehicle 1.0 1.2 3.1 0.6 1.8 0.8 0.8
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 3.8 1.3 1.2 1.9 1.5
Medication: Aspirin 2.4 3.2 5.7 -2.0 -0.2 -1.7 -2.4
Supplements: Vitamin C 0.3 0.3 0.9 0.3 0.2 0.5 0.9
Knee pain experienced in last month 1.0 1.5 4.0 -1.0 -0.4 -0.9 -2.0
Hypertension (Self-reported) 1.6 4.4 9.2 -1.8 -1.6 -1.5 -3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 4.6 1.2 -0.9 2.1 1.4
Illnesses of father: Heart disease 0.7 1.0 1.9 0.8 0.9 1.4 0.8
Illnesses of siblings: Diabetes 0.8 1.0 2.2 -1.1 -1.5 -0.5 -0.6
Smoking status: Previous 3.1 4.6 8.1 2.2 0.4 2.3 2.8
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 4.8 1.3 1.0 2.2 1.4
Whole body fat-free mass 0.2 1.1 1.9 -1.0 1.1 1.4 -0.5
Leg fat-free mass (right) 0.4 2.0 3.9 -0.3 1.9 2.0 0.6
Arm fat percentage (left) 0.5 1.9 4.5 1.4 -0.8 2.1 1.0
Average weekly red wine intake 0.2 0.4 1.1 0.3 0.2 1.1 0.4
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 -0.5 -0.7 0.3 -0.1
Mood swings 6.3 11.4 22.1 -3.1 -1.8 -3.2 -4.7
Loneliness, isolation 0.6 0.8 1.9 -0.7 0.7 -1.4 -0.6
Long-standing illness, disability or infirmity 2.6 3.9 6.3 -1.6 -2.1 -1.4 -2.5
Ever had bowel cancer screening 1.0 1.2 2.0 1.0 -1.1 1.4 0.7
Diabetes diagnosed by doctor 0.3 0.6 1.1 -0.7 -1.1 -0.1 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 0.9 0.8 -0.8 0.9 0.8
Friendships satisfaction 0.4 0.5 1.4 0.5 -1.2 0.4 -0.1
Qualifications: nursing, teaching 0.6 0.9 1.7 0.7 1.3 1.0 0.7
Commuting to job workplace: Walk 0.4 0.4 0.7 -0.8 0.3 -0.6 -0.7
Eye problems/disorders: Cataract 0.4 0.4 0.8 -0.1 0.7 0.9 0.7
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.2 0.2 -0.5 -0.1 -0.1
Medication for cholesterol 1.1 1.6 2.7 1.0 1.6 0.5 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.3 2.7 5.3 1.7 1.2 1.0 2.3
Back pain experienced in last month 8.9 12.9 16.1 -3.5 -3.4 -3.5 -4.0
Mineral and other dietary supplements 2.0 2.7 5.2 -1.4 0.1 -2.3 -1.9
Breast cancer (self-reported) 4.1 4.9 7.9 -2.5 -0.5 -2.8 -2.3
Asthma (self-reported) 2.6 5.2 9.0 -1.4 -1.5 -2.8 -3.0
Osteoporosis (self-reported) 1.3 1.6 2.7 1.0 0.5 1.5 1.6
Osteoarthritis (self-reported) 0.2 0.2 0.7 -0.3 -0.4 0.1 -0.8
Medication: Aspirin 3.0 3.9 6.6 -2.3 -0.6 -1.9 -2.6
Medication: Gliclazide 0.3 0.3 0.4 0.3 -0.6 0.5 0.7
Illnesses of father: None of the above (group 1) 1.2 1.5 2.7 1.2 0.2 1.6 1.3
Smoking status: Current 1.0 1.6 2.1 -1.4 -1.0 -1.1 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.1 5.2 1.5 1.9 1.3 2.3
Whole body water mass 0.2 1.0 2.0 -0.9 1.1 1.4 -0.3
Leg predicted mass (right) 0.4 1.9 3.8 -0.3 1.9 1.9 0.5
Arm fat mass (left) 0.3 1.1 3.5 0.5 -0.7 1.9 0.3
Number of self-reported non-cancer illnesses 1.5 2.5 7.3 -1.0 -2.7 -0.7 -1.2
Average weekly champagne plus white wine intake 1.5 2.1 5.1 1.4 2.3 1.1 0.1
Miserableness 6.3 10.8 15.7 -3.5 -0.5 -4.0 -3.9
Guilty feelings 0.4 0.6 0.9 -0.9 -0.2 -1.0 -0.7
Wears glasses or contact lenses 0.3 0.4 1.1 -0.0 -0.7 0.1 -1.0
Ever taken oral contraceptive pill 0.4 0.5 1.4 0.1 -1.2 -0.4 -0.6
Hearing aid user 0.9 1.0 2.3 -0.3 -1.5 -0.7 -1.1
Mother’s age at death 1.6 2.0 5.0 1.0 2.2 1.2 0.8
Financial situation satisfaction 0.5 0.6 1.6 1.2 -0.7 -0.4 0.3
Tinnitus: Yes, now most or all of the time 1.7 1.9 3.7 -1.1 -0.1 -1.9 -1.7
Commuting to job workplace: Public transport 1.4 1.6 5.8 -0.0 -2.4 -0.0 -0.9
Eye problems/disorders: Glaucoma 0.7 0.9 1.6 0.8 0.9 0.8 1.3
Medication: Blood pressure 3.7 7.0 17.1 -2.2 -1.2 -2.2 -4.1
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.0 1.0 -0.6 1.4 1.0
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.7 -0.0 -0.7 1.2 1.3
High cholesterol (Self-reported) 0.1 0.2 0.8 -0.1 -0.9 0.2 0.0
Medication: Bendroflumethiazide 4.5 6.9 9.7 -3.0 -2.2 -2.0 -3.1
Medication: Paracetamol 0.6 0.9 2.0 -0.4 -1.2 0.2 -1.4
Medication: Lisinopril 3.7 4.7 10.8 -1.6 -0.5 -2.3 -3.3
Medication: Atorvastatin 1.8 2.2 3.2 -1.4 -1.7 -0.9 -1.8
Illnesses of father: High blood pressure 6.0 7.4 11.6 -3.4 0.6 -3.2 -2.7
Alcohol drinker status: Never 0.6 0.7 1.9 -0.6 0.6 -0.4 -1.4
Ever smoked 1.0 1.7 3.3 0.7 1.1 1.4 1.8
Basal metabolic rate 0.2 0.9 2.6 -0.7 0.8 1.6 -0.3
Leg fat percentage (left) 0.7 2.5 9.0 0.2 -3.0 0.7 -0.7
Arm fat-free mass (left) 0.2 0.8 1.8 -1.4 0.0 0.8 -0.9
Number of operations (self-reported) 0.8 1.2 2.0 1.0 -0.3 1.4 1.3
Average weekly beer plus cider intake 0.9 1.3 2.8 -1.0 -1.7 -0.5 -1.2
Irritability 9.9 16.8 22.9 -4.6 -1.9 -4.5 -4.8
Risk taking 0.6 0.9 1.6 -0.5 -1.3 -0.7 -1.1
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.5 0.4 -0.5 0.7 0.6
Fractured/broken bones in last 5 years 0.9 1.1 3.5 1.9 0.4 0.7 0.6
Age started oral contraceptive pill 0.2 0.2 0.5 0.7 0.5 0.5 0.1
Diastolic blood pressure, automated reading 0.3 1.1 2.6 1.6 -0.4 1.1 -0.4
Ever depressed for a whole week 1.4 1.8 3.1 -1.1 0.0 -1.8 -1.6
Unable to work because of sickness or disability 0.6 0.8 2.0 0.5 1.4 0.6 0.7
Commuting to job workplace: Cycle 1.0 1.3 2.5 1.4 1.6 0.6 0.2
Myopia 2.0 2.8 6.7 2.6 0.8 1.8 0.9
Vascular/heart problems diagnosed by doctor 1.2 3.4 6.9 1.6 1.6 1.2 2.6
Cholesterol lowering medication 0.9 1.3 2.6 -0.9 -1.6 -0.3 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.4 -0.7 -1.2 -0.2 -0.4
Pain experienced in last month 8.0 13.3 21.9 3.4 2.6 3.6 4.7
Supplements: Calcium 0.8 0.8 1.7 0.6 0.7 0.9 1.3
Basal cell carcinoma (self-reported) 3.2 3.8 7.2 -2.7 -1.0 -1.9 -1.9
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.8 -0.1 -1.3 -0.6 -0.9
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 2.8 -1.7 1.1 -1.2 -1.0
Heart disease (siblings) 1.9 2.4 4.1 -1.4 -0.4 -2.0 -1.8
Alcohol drinker status: Previous 1.6 1.8 3.3 -0.7 -1.8 -1.2 -1.4
Pack years of smoking 0.6 0.9 2.8 -0.7 -1.7 0.0 -0.7
Impedance of whole body 1.5 7.5 16.1 4.0 -0.3 2.3 2.9
Leg fat mass (left) 0.3 1.4 3.8 0.1 -2.0 1.2 -0.5
Arm predicted mass (left) 0.2 0.8 1.4 -1.1 0.2 1.2 -0.7