TWAS hub - PIEZO1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.111	0.0370	0.00071	0.111	NA	0.071	NA	0.112	1.1e-08	NA	5.5e-06	NA	1.0e-08
2	GTEx	Heart Left Ventricle	0.164	0.0703	0.01000	0.000	NA	0.013	NA	0.006	3.4e-01	NA	6.7e-02	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Platelet Count	7.6	87.9	134.6	6.4	11.6
Wheeze or whistling in the chest in last year	7.2	12.9	15.7	3.2	4.0
Irritability	6.1	10.3	17.3	1.8	4.2
Mood swings	5.6	10.2	13.8	2.6	3.7
Lung FVC	5.3	27.2	30.9	-5.6	-4.8
Neuroticism score	4.8	10.1	10.1	3.2	3.2
Hair Pigment	4.5	127.7	222.0	-14.9	5.8
Average weekly spirits intake	4.3	5.4	7.1	1.9	2.7
Illness, injury, bereavement, stress in last 2 years	4.2	5.1	6.6	-2.6	-1.9
Pain experienced in last month	4.0	6.7	9.9	-1.9	-3.2
Blood Eosinophil Count	3.9	29.8	57.9	1.3	7.6
Long-standing illness, disability or infirmity	3.9	5.9	6.3	2.3	2.5
Chest pain or discomfort	3.8	5.4	9.3	1.3	3.0
Back pain experienced in last month	3.8	5.5	6.2	2.5	2.2
Fed-up feelings	3.7	6.7	8.9	2.1	3.0
Handedness (chirality/laterality): Left-handed	3.5	4.2	5.7	-1.7	-2.4
Neuroticism (2016)	3.4	4.8	7.2	2.7	1.6
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.5	7.5	1.9	2.7
Asthma (self-reported)	3.4	6.7	9.0	2.1	3.0
Asthma	3.3	6.5	8.6	2.1	2.9
Bipolar Disorder (2018)	3.1	5.0	7.6	1.5	2.8
Blood clot in the leg (DVT)	3.1	4.0	6.3	-2.5	-1.3
Medication: Paracetamol	3.1	5.1	8.9	1.1	3.0
Medication: Ibuprofen	3.1	3.7	4.7	2.2	1.7
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.5	11.5	3.4	1.2
Neuroticism	3.0	7.3	8.9	2.4	3.0
Tanning	2.9	35.0	47.9	6.9	-4.7
Pulse rate, automated reading	2.9	9.3	13.0	3.6	2.4
Blood Red Count	2.8	26.9	39.4	-3.8	-6.3
Noisy workplace	2.7	3.4	6.1	-0.8	-2.5
Respiratory disease	2.6	5.8	5.9	2.4	2.4
Serious illness, injury or assault of a close relative in last 2 years	2.6	3.0	5.2	0.9	2.3
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	3.5	1.9	1.7
Leg fat percentage (right)	2.6	9.4	10.9	3.3	2.8
Arm fat-free mass (right)	2.6	13.3	17.3	4.2	3.0
Comparative height size at age 10	2.6	14.3	21.7	4.7	2.6
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	5.5	-0.2	-2.4
Supplements: Fish oil (including cod liver oil)	2.6	3.4	5.9	-0.9	-2.4
Arm fat-free mass (left)	2.6	13.1	18.2	4.3	2.8
Arm predicted mass (left)	2.6	13.0	17.6	4.2	2.9
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	3.8	2.0	1.6
Standing height	2.5	25.1	38.3	6.2	3.5
Arm predicted mass (right)	2.5	13.0	16.9	4.1	3.0
Medication: Co-codamol	2.4	2.8	4.6	1.0	2.1
Impedance of leg (right)	2.4	11.6	14.2	3.8	3.0
Heart attack	2.4	3.1	4.7	-2.2	-1.2
Trunk fat-free mass	2.4	13.9	18.0	4.2	3.1
Prospective memory result	2.4	2.9	3.3	1.8	1.6
Height	2.3	43.6	66.4	8.2	4.6
Trunk predicted mass	2.3	13.1	17.0	4.1	3.0
Headache pain in last month	2.3	4.0	6.9	1.1	2.6
Leg fat mass (right)	2.3	8.9	12.0	3.5	2.4
Mineral and other dietary supplements	2.3	3.2	4.9	1.2	2.2
Medication: Paracetamol	2.3	3.5	6.4	0.8	2.5
Leg fat mass (left)	2.3	8.8	11.6	3.4	2.5
Sensitivity / hurt feelings	2.2	3.8	4.1	1.9	2.0
Medication for hormone replacement therapy	2.2	2.4	4.7	2.2	0.4
Gout (self-reported)	2.2	3.1	5.3	0.9	2.3
Number of full brothers	2.2	2.8	5.5	-0.4	-2.4
Had major operations	2.2	2.5	3.8	-2.0	-1.1
Illnesses of father: Heart disease	2.2	3.1	3.3	-1.8	-1.7
Basal metabolic rate	2.1	11.4	15.1	3.9	2.8
Leg fat percentage (left)	2.1	7.7	8.6	2.9	2.6
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	5.2	-2.3	-0.6
Body Mass Index (BMI) (2010)	2.0	2.8	4.4	-2.1	-1.1
Pack years adult smoking proportion	2.0	3.1	4.4	1.4	2.1
Stomach or abdominal pain in last month	2.0	2.5	3.5	1.2	1.9
Health satisfaction	2.0	2.6	4.5	2.1	0.9
Suffer from ‘nerves’	2.0	3.1	3.2	1.7	1.8
Breast Cancer	1.9	4.6	5.2	-2.0	-2.3
Medication: Atenolol	1.9	2.4	4.8	-2.2	-0.1
Impedance of leg (left)	1.9	9.0	11.0	3.3	2.7
Weight	1.9	9.3	13.0	3.6	2.4
Falls in the last year	1.9	2.5	2.7	1.7	1.5
Osteoporosis (self-reported)	1.9	2.3	3.0	-1.3	-1.7
Heart attack/myocardial infarction (self-reported)	1.9	2.5	3.5	-1.9	-1.2
Pack years of smoking	1.9	2.7	3.9	1.2	2.0
Multivitamins +/- minerals	1.8	2.3	3.0	1.7	1.3
Waist circumference	1.8	6.8	10.8	3.3	1.6
Nervous feelings	1.8	3.4	5.3	2.3	1.2
Father’s age at death	1.8	2.4	3.5	1.9	1.1
Whole body fat-free mass	1.8	10.3	13.7	3.7	2.6
Whole body water mass	1.8	10.4	14.4	3.8	2.5
Bipolar Disorder or Schizophrenia	1.7	4.2	4.4	2.0	2.1
Neck or shoulder pain in last month	1.7	2.4	2.6	1.5	1.6
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.2	1.8	-0.6
Trunk fat mass	1.6	7.1	11.2	3.3	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.7	-1.7	-1.1
Alcohol intake frequency.	1.6	3.7	6.9	-2.6	-0.7
Knee pain experienced in last month	1.6	2.4	3.4	1.2	1.8
Smoking status: Previous	1.6	2.3	4.5	-0.4	-2.1
Relative age voice broke	1.5	2.4	3.2	-1.8	-1.2
Breastfed as a baby	1.5	1.9	3.6	0.3	-1.9
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.7	2.2	0.4
Number of children fathered	1.5	1.7	1.7	-1.3	-1.3
Smoking status: Current	1.5	2.3	3.0	1.3	1.7
Ever taken oral contraceptive pill	1.5	1.6	3.2	1.8	0.2
Supplements: Calcium	1.5	1.6	3.1	-0.3	-1.8
Alcohol drinker status: Previous	1.5	1.7	3.0	-1.7	-0.6
Depressed Affect (Nagel 2018)	1.4	3.0	4.6	1.1	2.1
Reaction Time	1.4	2.7	5.0	2.2	-0.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.6	0.3	1.9
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.2	1.8	0.5
Whole body fat mass	1.4	5.7	8.9	3.0	1.6
Neuroticism (Nagel 2018)	1.3	3.1	4.2	1.4	2.1
HDL Cholesterol	1.3	2.1	4.1	-2.0	-0.3
Type 2 Diabetes (T2D) (2018)	1.3	2.4	2.9	1.4	1.7
Relative age of first facial hair	1.3	2.6	4.3	-2.1	-0.9
Mouth/teeth dental problems	1.3	2.1	3.2	-1.0	-1.8
Lung cancer (father)	1.3	1.6	3.1	-0.3	-1.8
Medication for pain relief, constipation, heartburn	1.3	2.3	4.3	-0.4	-2.1
Number of operations (self-reported)	1.3	1.9	2.7	-1.6	-1.0
Irritable Bowel Disease (IBD)	1.2	2.8	3.0	1.7	1.6
Mean time to correctly identify matches	1.2	2.4	4.2	0.7	-2.0
Commuting to job workplace: Walk	1.2	1.3	2.5	1.6	0.4
Myopia	1.2	1.8	3.4	0.3	1.9
Ulcerative Colitis (UC)	1.1	2.1	2.2	1.5	1.5
Lung FEV1/FVC ratio	1.1	5.7	9.2	3.0	1.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	1.7	1.1	1.3
Supplements: Zinc	1.1	1.2	2.3	-0.3	1.5
Current tobacco smoking	1.1	1.8	2.6	1.0	1.6
Supplements: Glucosamine	1.1	1.4	1.9	-1.4	-1.0
Hip circumference	1.1	4.8	6.7	2.6	1.7
Worrier / anxious feelings	1.1	2.1	3.0	1.7	1.1
Age at first live birth	1.1	1.9	3.8	0.0	1.9
Overall health rating	1.1	2.5	3.6	1.9	1.1
Diabetes diagnosed by doctor	1.1	1.8	2.7	1.7	1.0
Guilty feelings	1.1	1.6	2.0	1.4	1.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.2	-1.5	-0.7
Age started oral contraceptive pill	1.1	1.4	2.4	-1.6	-0.6
Waist Hip Ratio (WHR)	1.0	4.5	7.2	2.7	1.4
Severe depression (siblings)	1.0	1.1	1.2	1.0	1.1
Hearing difficulty/problems with background noise	1.0	1.7	1.9	-1.4	-1.2
Happiness	1.0	1.2	1.6	1.3	0.9
Tense / ‘highly strung’	1.0	1.7	2.3	1.1	1.5
Birth weight	1.0	2.1	4.2	0.0	2.0
Migraine (self-reported)	1.0	1.3	1.7	-0.9	1.3
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.4	-1.6	0.0
Pain type(s) experienced in last month: Hip pain	1.0	1.3	1.7	0.9	1.3
Cholesterol lowering medication	1.0	1.5	2.4	0.8	1.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.4	0.3	1.5
Worry (Nagel 2018)	0.9	1.8	2.0	1.3	1.4
Ovarian Cancer	0.9	1.2	1.3	-1.0	-1.1
Ulcerative Colitis	0.9	1.4	2.7	1.7	0.0
Systolic blood pressure, automated reading	0.9	2.5	4.4	-0.8	-2.1
Leg fat-free mass (left)	0.9	4.9	7.0	2.6	1.7
Trunk fat percentage	0.9	3.4	6.1	2.5	0.9
Average weekly fortified wine intake	0.9	1.0	1.9	-0.3	1.4
Qualifications: CSEs or equivalent	0.9	1.1	2.1	-0.4	1.5
Leg predicted mass (left)	0.9	4.9	6.9	2.6	1.7
Number of incorrect matches in round	0.9	1.5	2.8	0.4	-1.7
Pulse wave Arterial Stiffness index	0.9	1.0	1.1	1.0	-1.0
Body fat percentage	0.9	3.7	5.8	2.4	1.2
Emphysema/chronic bronchitis	0.9	1.0	1.8	0.5	-1.4
Medication: Allopurinol	0.9	1.2	2.4	0.2	1.6
Number of full sisters	0.9	1.1	1.4	-0.8	-1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.7	-1.9	-0.2
Rheumatoid Arthritis	0.8	1.1	2.2	1.5	-0.1
Triglycerides	0.8	1.4	2.7	-0.2	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.4	0.9	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.4	0.6	-1.2
Pulse rate	0.8	1.4	1.6	1.3	1.1
Depression (self-reported)	0.8	1.0	1.1	1.1	-1.0
Birth weight of first child	0.8	1.5	1.9	1.0	1.4
Worry too long after embarrassment	0.8	1.3	1.8	0.9	1.3
Shortness of breath walking on level ground	0.8	1.0	1.9	1.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.0	-1.0	-1.0
Qualifications: nursing, teaching	0.8	1.2	2.3	0.2	1.5
Financial situation satisfaction	0.8	1.0	1.6	0.7	-1.2
Schizophrenia (2018)	0.7	1.4	1.9	1.4	0.9
Heel T-Score	0.7	5.6	10.5	3.2	0.8
Number of treatments/medications taken	0.7	1.3	2.2	0.5	1.5
Age when periods started (menarche)	0.7	1.8	3.5	-1.9	-0.4
Sitting height	0.7	5.2	6.9	2.6	1.9
Past tobacco smoking	0.7	1.3	2.4	-0.3	1.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.8	1.4	0.2
Pulse wave reflection index	0.7	0.9	1.3	-0.7	-1.1
Pulse wave peak to peak time	0.7	0.8	1.5	-0.4	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	1.7	-1.1	-1.3
Miserableness	0.7	1.2	1.5	0.9	1.2
Alcohol drinker status: Never	0.7	0.8	0.9	-1.0	0.8
Alzheimer’s Disease (in father)	0.6	0.6	0.8	0.7	-0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	0.9	0.8	0.9
Townsend deprivation index at recruitment	0.6	0.8	1.6	-1.2	0.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.5	-0.2	-1.6
Had other major operations	0.6	0.8	1.3	-0.5	-1.1
Illnesses of siblings	0.6	0.9	1.2	1.1	0.8
Medication: Lansoprazole	0.6	0.6	1.3	1.1	-0.0
Arm fat mass (right)	0.6	2.3	3.9	2.0	0.8
Medication: Omeprazole	0.6	0.7	1.3	-0.3	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.0	-0.7	-1.0
Leg predicted mass (right)	0.6	3.0	4.2	2.1	1.3
Arm fat mass (left)	0.6	2.5	3.9	2.0	1.0
Medication: Blood pressure	0.6	1.1	2.2	-1.5	-0.3
Mean Putamen Volume	0.5	0.5	0.7	0.8	0.6
Serious illness, injury or assault to yourself	0.5	0.6	0.9	1.0	0.6
Financial difficulties in last 2 years	0.5	0.6	0.7	0.8	0.7
Alcohol intake versus 10 years previously	0.5	0.7	1.4	1.2	-0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.3	0.3	1.5
Length of working week for main job	0.5	0.6	0.9	0.5	-0.9
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.3	0.1	1.1
Loud music exposure frequency	0.5	0.5	1.0	-0.2	1.0
High blood pressure (siblings)	0.5	0.8	1.6	-1.3	-0.0
Leg fat-free mass (right)	0.5	2.9	4.3	2.1	1.3
Osteoarthritis (self-reported)	0.5	0.7	1.3	0.3	1.1
Average weekly champagne plus white wine intake	0.5	0.6	0.8	-0.7	0.9
Medication: Bendroflumethiazide	0.5	0.8	1.0	1.0	0.8
Basal cell carcinoma (self-reported)	0.5	0.5	0.6	0.8	-0.7
Prostate Cancer	0.4	0.6	0.7	-0.8	-0.7
Age at First Birth	0.4	0.6	1.2	-0.1	1.1
Systolic Blood Pressure	0.4	2.1	4.1	-0.3	-2.0
Smoking Status	0.4	1.0	1.9	1.4	0.4
Cardiovascular Disease	0.4	1.3	2.6	1.6	0.1
Hand grip strength (left)	0.4	1.1	1.1	1.1	1.0
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	1.0	-0.2
Diabetes (mother)	0.4	0.5	1.0	-0.1	-1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.7	-0.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.1	1.0	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.5	-0.7	0.7
High blood pressure (mother)	0.4	0.5	1.0	-1.0	-0.3
Hair/balding pattern: Pattern 2	0.4	0.4	0.8	-0.9	0.3
Fluid intelligence score	0.4	0.9	1.6	-1.3	0.5
Exposure to tobacco smoke at home	0.4	0.5	0.9	0.9	-0.2
Medication: Seretide 50 evohaler	0.4	0.5	0.9	0.3	0.9
Age at last live birth	0.4	0.6	1.0	0.3	1.0
Medication: Aspirin	0.4	0.5	1.0	-1.0	0.1
Illnesses of father: None of the above (group 1)	0.4	0.5	0.6	0.8	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.1	1.0
Illnesses of father: High blood pressure	0.4	0.4	0.8	-0.2	0.9
Heart disease (siblings)	0.4	0.6	1.1	-1.0	-0.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.4	-0.4	0.6
Crohns Disease (2017)	0.3	0.7	0.8	0.8	0.9
Fasting Glucose	0.3	0.4	0.5	0.4	0.7
Schizophrenia (2014)	0.3	0.6	1.2	1.1	-0.1
Blood White Count	0.3	2.4	4.5	0.6	2.1
Hypothyroidism (self reported)	0.3	0.6	0.7	0.8	0.8
Vitamin and mineral supplements	0.3	0.5	0.5	-0.7	-0.7
Medication: Metformin	0.3	0.4	0.7	0.8	0.3
Diabetes (father)	0.3	0.4	0.7	0.4	0.8
Taking other prescription medications	0.3	0.4	0.8	0.3	0.9
Medication: Levothyroxine sodium	0.3	0.4	0.9	0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.1	1.0	0.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	0.4	0.7
Diabetes (self-reported)	0.3	0.4	0.7	0.8	0.4
Hair/balding pattern: Pattern 3	0.3	0.4	0.4	-0.6	0.6
Peak expiratory flow (PEF)	0.3	0.7	1.2	-0.5	-1.1
Glaucoma (self-reported)	0.3	0.3	0.4	-0.5	0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	1.6	-0.7	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.5	0.7	0.3
Qualifications: College or University degree	0.3	1.0	1.6	-0.6	1.3
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.8	0.1
Illnesses of siblings: Diabetes	0.3	0.3	0.5	0.4	0.7
Medication: Aspirin	0.3	0.3	0.7	-0.8	-0.0
Medication: Gliclazide	0.3	0.3	0.7	0.1	0.8
Ever smoked	0.3	0.5	0.9	0.9	0.2
Risk taking	0.3	0.5	0.9	1.0	-0.2
Commuting to job workplace: Cycle	0.3	0.4	0.6	-0.8	-0.4
Depression (Nagel 2018)	0.2	0.3	0.4	-0.7	0.4
Lupus	0.2	0.3	0.5	0.7	0.0
Allergy or Eczema	0.2	0.5	1.0	-0.2	-1.0
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.0	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.4	-0.6	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.8	0.1
Forced vital capacity (FVC)	0.2	0.7	1.1	-0.5	-1.0
Pain all over the body in last month	0.2	0.2	0.3	-0.5	0.4
Medication: Simvastatin	0.2	0.3	0.5	-0.4	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.1	0.4	-1.0
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.3	-0.7
Illnesses of mother	0.2	0.2	0.3	0.5	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.4	-0.3	-1.2
Impedance of arm (left)	0.2	0.8	1.0	-0.8	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.9	0.9	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.3	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	-0.5	0.4
Average weekly red wine intake	0.2	0.3	0.7	0.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.6	-0.0
Mother’s age at death	0.2	0.3	0.5	-0.4	0.7
Medication: Atorvastatin	0.2	0.3	0.3	0.5	0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.3	-0.4	-0.6
HbA1C	0.1	0.1	0.1	-0.0	0.4
LDL Cholesterol	0.1	0.1	0.3	0.0	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.1	0.2	0.4
BMI	0.1	0.7	1.3	1.1	0.4
Chronotype (morning person)	0.1	0.3	0.4	-0.5	-0.6
Maternal smoking around birth	0.1	0.1	0.2	0.1	-0.5
Body mass index (BMI)	0.1	0.6	0.6	0.8	0.7
Had menopause	0.1	0.1	0.2	-0.0	-0.5
Qualifications: None of the above	0.1	0.2	0.4	-0.6	0.2
Medication: Ramipril	0.1	0.2	0.3	0.1	-0.6
Impedance of arm (right)	0.1	0.6	1.0	-0.5	-1.0
Arm fat percentage (right)	0.1	0.3	0.6	0.8	0.1
Number of live births	0.1	0.2	0.2	0.4	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	-0.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	-0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	-0.0	0.6
Medication: Amlodipine	0.1	0.1	0.1	-0.3	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.2	0.4	0.4
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.6	0.0
Medication: Blood pressure	0.1	0.2	0.3	-0.5	-0.3
Heart disease (mother)	0.1	0.1	0.2	-0.0	-0.5
Family relationship satisfaction	0.1	0.2	0.3	-0.6	0.1
Leg pain on walking	0.1	0.1	0.1	0.3	-0.3
Supplements: Vitamin C	0.1	0.1	0.2	-0.1	0.5
Hypertension (Self-reported)	0.1	0.2	0.2	-0.4	-0.4
Arm fat percentage (left)	0.1	0.3	0.5	0.7	0.1
Eye problems/disorders: Cataract	0.1	0.2	0.3	-0.2	0.5
Medication for cholesterol	0.1	0.1	0.2	-0.5	-0.1
Breast cancer (self-reported)	0.1	0.1	0.1	0.2	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.3	0.6
Wears glasses or contact lenses	0.1	0.2	0.3	-0.1	-0.5
Hearing aid user	0.1	0.1	0.1	0.2	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.5	-0.3
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.3	-0.6
Diastolic blood pressure, automated reading	0.1	0.3	0.6	0.8	-0.0
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.3	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	0.4	0.7
Impedance of whole body	0.1	0.6	0.9	1.0	0.6
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.4	-0.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.2	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Angina	0.0	0.0	0.1	-0.2	-0.2
Hand grip strength (right)	0.0	0.0	0.0	0.0	0.1
High blood pressure	0.0	0.1	0.1	-0.4	-0.2
Alcohol usually taken with meals	0.0	0.0	0.1	-0.1	-0.2
Allergy	0.0	0.0	0.1	-0.3	-0.0
Time employed in main current job	0.0	0.0	0.1	0.2	0.0
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	0.3	0.2
Comparative body size at age 10	0.0	0.0	0.1	-0.1	0.3
Angina (self-reported)	0.0	0.0	0.0	-0.1	-0.2
Loneliness, isolation	0.0	0.0	0.0	-0.1	0.0
Ever had bowel cancer screening	0.0	0.0	0.0	-0.0	0.1
Friendships satisfaction	0.0	0.0	0.1	-0.0	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	0.2	0.0
Medication: Lisinopril	0.0	0.0	0.0	0.1	-0.0
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	-0.1
Ever depressed for a whole week	0.0	0.1	0.1	-0.3	-0.2

Hub : Genes

PIEZO1

Models

Trait associations