TWAS hub - SLC7A5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.1260	0.0450	1.4e-03	0.009	NA	0.022	NA	0.016	5.2e-02	NA	6.0e-03	NA	1.6e-02
2	TCGA	Bladder Urothelial Carcinoma	0.0750	0.0370	2.7e-03	-0.001	0.026	0.002	NA	0.003	4.0e-01	2.6e-03	2.2e-01	NA	1.6e-01
3	TCGA	Breast Invasive Carcinoma	0.0486	0.0196	2.5e-07	0.052	0.031	0.037	NA	0.047	8.1e-11	3.8e-07	4.3e-08	NA	5.1e-10
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0950	0.0399	1.2e-03	0.037	0.038	0.046	NA	0.038	4.3e-05	4.0e-05	6.3e-06	NA	3.7e-05
5	TCGA	Thyroid Carcinoma	0.0820	0.0310	8.7e-04	0.061	0.038	0.060	NA	0.058	1.4e-06	1.2e-04	1.5e-06	NA	2.3e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Schizophrenia vs Biploar Disorder	3.7	4.9	11.8	1.4	3.2	3.4	0.0	0.0
Birth weight	3.7	8.1	13.0	-2.1	-3.4	-3.6	-2.4	-2.4
Myopia	3.6	5.2	9.4	-2.4	-2.3	-3.1	-2.2	-0.6
Alzheimer’s Disease (in mother)	3.4	3.9	7.4	-1.5	-2.3	-1.2	-2.7	-1.8
Medication: Co-codamol	3.4	4.0	9.3	-0.7	-0.6	-2.1	2.3	3.0
Nervous feelings	3.4	6.4	13.5	2.1	3.1	3.7	-1.7	-1.1
Worry (Nagel 2018)	3.2	6.7	16.3	2.2	3.2	4.0	-0.7	-1.2
Illnesses of mother	3.1	3.8	9.8	1.7	3.1	1.4	1.0	1.8
Pulse rate	3.0	5.0	9.8	-2.4	-3.0	-3.1	-0.6	-0.4
Neuroticism	2.9	7.0	17.6	2.9	2.8	4.2	1.1	0.1
Worrier / anxious feelings	2.9	5.5	10.6	2.8	1.4	3.3	-1.7	-2.0
Number of children fathered	2.9	3.3	4.5	0.9	2.1	1.9	2.1	1.8
Pain all over the body in last month	2.6	2.8	5.8	0.4	2.3	1.4	2.4	0.8
Neuroticism score	2.4	5.1	12.4	2.5	2.6	3.5	0.4	-0.5
Emphysema/chronic bronchitis	2.4	2.7	6.5	-1.4	-2.6	-1.9	-1.0	-0.2
Hearing aid user	2.4	2.7	6.0	2.4	2.1	1.7	-0.4	0.6
Neuroticism (Nagel 2018)	2.3	5.5	15.0	2.0	2.7	3.9	-0.1	-1.0
Average weekly spirits intake	2.2	2.8	4.4	1.0	1.8	1.4	2.1	1.8
Sensitivity / hurt feelings	2.2	3.8	12.9	1.7	1.9	3.6	-0.1	0.2
Supplements: Zinc	2.2	2.4	3.8	-2.0	-1.5	-0.6	-1.6	-1.7
Relative age voice broke	2.2	3.3	6.4	-1.7	-1.7	-1.6	-2.5	-1.4
Medication: Ramipril	2.2	2.9	4.9	-1.8	-2.1	-2.2	-1.3	-0.0
Suffer from ‘nerves’	2.2	3.4	7.3	1.6	2.5	2.7	-0.6	-0.9
Heart disease (mother)	2.0	2.5	5.8	-1.8	-2.4	-1.1	-0.9	-1.2
Pulse rate, automated reading	2.0	6.6	16.9	-2.2	-3.2	-4.1	-0.9	0.1
Ever had hysterectomy (womb removed)	1.9	2.1	3.5	1.6	1.9	1.8	-1.0	-0.8
Glaucoma (self-reported)	1.9	2.3	4.8	-1.3	-2.2	0.0	-1.9	-1.1
Supplements: Vitamin C	1.9	2.2	4.0	-1.3	-1.1	-1.5	-1.3	-2.0
Handedness (chirality/laterality): Left-handed	1.9	2.2	5.1	-2.0	-0.2	-0.4	-2.3	-1.4
Supplements: Calcium	1.9	2.1	6.2	-0.1	2.5	1.7	1.2	-0.2
Neuroticism (2016)	1.8	2.5	5.8	1.6	2.0	2.4	0.2	-0.4
High blood pressure (mother)	1.8	2.5	9.5	-0.8	-3.1	-0.2	-1.1	-1.1
Alzheimer’s Disease (including proxy)	1.7	2.5	4.5	-1.4	-2.1	-0.9	-2.0	-1.2
Maternal smoking around birth	1.7	2.4	5.0	0.5	1.9	0.2	1.8	2.2
Chronic bronchitis/emphysema (father)	1.7	2.0	2.7	-1.6	-1.6	-1.2	-1.6	-0.8
Hair/balding pattern: Pattern 2	1.7	2.2	4.0	-0.8	-1.5	-0.1	-2.0	-1.9
Number of live births	1.7	2.3	4.1	0.1	-1.1	-1.6	2.0	1.9
Noisy workplace	1.7	2.1	6.7	-0.0	0.1	-1.1	1.6	2.6
Exposure to tobacco smoke at home	1.7	1.9	2.8	1.6	1.7	1.5	1.3	0.4
Ever taken oral contraceptive pill	1.7	1.9	3.3	-0.8	-1.1	-1.8	1.8	0.9
Commuting to job workplace: Public transport	1.7	2.1	8.5	-0.4	-0.6	0.1	-2.9	-1.2
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.1	-1.4	-1.1	-2.0	1.4	1.3
LDL Cholesterol	1.6	2.5	5.5	0.3	2.0	1.7	0.0	2.3
Blood Platelet Count	1.6	18.3	35.5	4.4	4.4	6.0	3.2	2.7
Type 2 Diabetes (T2D) (2018)	1.6	3.1	7.8	-1.9	-2.8	-1.8	-0.1	-0.8
Townsend deprivation index at recruitment	1.6	2.2	5.8	-1.2	-1.8	-2.4	-0.4	0.7
Medication: Blood pressure	1.6	2.8	4.2	-2.1	-1.9	-1.6	0.9	1.6
Smoking status: Previous	1.6	2.4	5.2	-1.5	1.6	0.3	2.3	1.4
Bipolar Disorder (2018)	1.5	2.3	5.9	-1.5	-2.4	-1.9	0.0	0.0
Medication: Levothyroxine sodium	1.5	2.6	5.4	-2.3	-1.8	-1.9	-0.9	-0.1
Medication: Omeprazole	1.5	1.7	3.1	-1.2	-0.7	-1.6	1.0	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.7	4.1	-0.5	-0.7	-2.0	-1.7	-0.6
Alcohol drinker status: Never	1.5	1.8	5.2	0.1	0.2	-0.3	-1.9	-2.3
Number of operations (self-reported)	1.5	2.2	7.2	-0.1	1.2	-0.4	1.4	2.7
Ulcerative Colitis (UC)	1.4	2.6	4.9	2.2	1.8	0.9	1.3	1.4
Diabetes (mother)	1.4	1.7	2.8	-1.0	-1.5	-0.7	-1.7	-1.5
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	2.9	-1.5	-1.7	-1.3	-1.0	-1.0
Asthma	1.4	2.8	6.6	0.0	1.2	-1.8	2.6	1.6
Depression (self-reported)	1.4	1.7	5.1	-0.7	0.7	0.5	2.2	1.4
Lung cancer (father)	1.4	1.7	4.7	-0.1	-1.2	-1.5	-2.2	0.2
Worry too long after embarrassment	1.4	2.3	3.5	1.9	1.6	1.7	-1.2	-1.2
Medication: Aspirin	1.4	1.8	4.6	0.7	-0.1	-0.5	1.9	2.1
Medication: Gliclazide	1.4	1.6	3.7	-0.6	-0.4	-1.9	1.0	1.6
Guilty feelings	1.4	2.1	7.2	1.5	0.6	2.7	-0.3	-0.6
Medication: Bendroflumethiazide	1.4	2.1	5.5	-1.9	-2.4	-0.4	-0.6	0.9
Multivitamins +/- minerals	1.3	1.7	2.9	1.6	1.7	0.7	1.6	0.4
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.7	-2.1	-2.4	-1.6	-0.0	-0.3
Angina (self-reported)	1.3	1.7	3.3	1.8	0.9	1.1	0.2	1.7
Illnesses of father: High blood pressure	1.3	1.6	2.7	-0.5	-1.5	-0.9	-1.6	-1.4
Irritability	1.3	2.3	4.7	1.7	1.7	2.2	0.8	-0.4
Mean Putamen Volume	1.2	1.4	2.6	-0.5	-1.2	-1.6	1.1	1.3
Relative age of first facial hair	1.2	2.4	8.0	-0.7	-0.8	-1.1	-2.8	-1.3
Vitamin and mineral supplements	1.2	1.7	3.1	-1.6	-1.8	-0.9	-1.3	0.4
Medication: Cholesterol lowering	1.2	1.9	3.2	-1.8	-1.4	-0.9	1.0	1.5
Tense / ‘highly strung’	1.2	2.0	3.8	1.9	1.4	1.9	0.8	0.2
Pulse wave reflection index	1.2	1.5	2.8	-1.2	-0.2	-0.7	1.7	1.6
Asthma (self-reported)	1.2	2.4	5.3	-0.2	0.9	-2.0	2.3	1.4
Fractured/broken bones in last 5 years	1.2	1.6	3.5	1.4	1.4	1.9	-0.2	-0.5
Schizophrenia (2018)	1.1	2.4	8.8	-1.4	-0.6	0.9	0.0	-3.0
Triglycerides	1.1	1.8	7.2	-0.4	0.9	-0.9	0.0	2.7
Allergy or Eczema	1.1	2.8	4.5	1.3	2.1	1.0	1.6	2.0
Medication: Metformin	1.1	1.6	4.2	-1.3	-1.4	-2.1	-0.1	-0.1
Average weekly fortified wine intake	1.1	1.2	2.9	-0.8	1.4	-0.5	1.7	0.8
Hayfever, allergic rhinitis or eczema	1.1	2.5	3.8	1.5	1.9	1.5	1.4	1.5
Illnesses of siblings	1.1	1.5	5.4	-2.3	-1.1	-0.7	-0.1	-0.6
Exposure to tobacco smoke outside home	1.1	1.5	4.1	-0.2	-1.5	0.7	-2.0	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.3	-0.6	1.2	1.5	1.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.4	-1.7	-1.2	-2.1	1.5	0.5
Tinnitus: Yes, now most or all of the time	1.1	1.2	3.9	0.2	-0.2	-0.3	1.5	2.0
Intelligence (Savage-Jansen 2018)	1.0	3.2	5.8	0.3	2.0	-0.9	2.4	2.3
HbA1C	1.0	1.1	2.1	0.3	-0.7	0.9	-1.4	-1.4
Angina	1.0	1.3	2.9	1.7	0.8	1.0	-0.2	1.4
Stomach or abdominal pain in last month	1.0	1.2	5.9	-0.1	-2.4	-0.5	0.2	-0.2
Had other major operations	1.0	1.3	2.9	1.3	1.7	1.0	-0.8	0.4
Allergy	1.0	2.3	4.9	-1.2	-1.4	-0.4	-2.2	-1.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.1	1.4	2.0	0.7	-0.5	-1.3
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.7	1.4	0.1	0.5	1.6	1.1
Average weekly beer plus cider intake	1.0	1.4	4.2	0.4	0.9	-1.2	2.1	0.6
Risk taking	1.0	1.5	4.8	1.4	0.2	2.2	0.2	-0.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.4	-1.2	-0.3	0.1	-1.4	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.8	-0.7	-1.0	-1.0	1.0	1.7
Fasting Glucose	0.9	1.1	4.0	-1.0	-0.3	-2.0	-0.1	0.7
Lupus	0.9	1.4	2.8	-0.7	-0.7	-1.2	1.7	1.3
Fed-up feelings	0.9	1.6	4.9	1.0	1.5	2.2	0.3	-0.1
Supplements: Glucosamine	0.9	1.2	2.8	-0.8	1.1	-1.0	0.7	1.7
Number of incorrect matches in round	0.9	1.5	2.9	-1.0	-1.2	1.7	-1.0	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.0	1.2	1.7	1.7	-0.2	-0.0
Pulse wave peak to peak time	0.9	1.0	2.4	0.3	0.5	-0.5	-1.4	-1.5
Medication: Allopurinol	0.9	1.2	3.3	1.2	-0.8	-1.8	-0.5	0.4
Average weekly champagne plus white wine intake	0.9	1.2	2.2	1.3	1.4	1.5	-0.3	0.2
Miserableness	0.9	1.6	2.9	0.8	1.7	1.7	1.3	0.2
Eye problems/disorders: Glaucoma	0.9	1.1	2.9	0.1	-0.8	0.9	-1.7	-1.0
Basal cell carcinoma (self-reported)	0.9	1.1	2.1	0.7	1.3	1.4	1.0	-0.3
Heart disease (siblings)	0.9	1.1	5.1	2.3	0.1	0.6	0.1	0.2
Depressed Affect (Nagel 2018)	0.8	1.6	4.3	1.0	1.5	2.1	0.6	-0.4
Crohns Disease (2017)	0.8	1.8	6.1	0.4	-0.2	1.0	-2.5	-1.3
Medication for hormone replacement therapy	0.8	0.9	3.1	-0.4	0.1	0.4	-1.8	-0.9
Past tobacco smoking	0.8	1.5	4.2	2.0	-0.5	0.4	-1.4	-0.9
Diabetes (self-reported)	0.8	1.3	3.1	-1.1	-1.8	-1.1	0.7	0.5
Alcohol intake versus 10 years previously	0.8	1.1	2.2	-1.1	-1.4	-1.5	-0.4	0.1
Father’s age at death	0.8	1.0	2.0	-0.1	1.3	-0.1	-1.2	-1.4
Pulse wave Arterial Stiffness index	0.8	0.9	2.2	-0.2	-0.7	0.5	1.3	1.5
Blood clot in the leg (DVT)	0.8	1.1	2.7	-0.3	-1.6	-1.0	1.2	0.4
Leg fat percentage (right)	0.8	2.7	4.7	-1.2	-0.9	-1.9	1.8	2.2
Medication: Ibuprofen	0.8	0.9	1.9	0.9	1.4	0.3	1.2	0.5
Leg fat mass (right)	0.8	2.9	5.3	-0.8	-0.8	-2.0	2.3	2.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.0	-0.4	-1.1	-0.6	1.1	1.4
Illnesses of siblings: Diabetes	0.8	1.0	2.5	1.0	-1.0	-1.6	-0.7	0.4
Friendships satisfaction	0.8	1.0	2.2	-1.3	-0.4	-1.5	0.1	1.0
Back pain experienced in last month	0.8	1.1	4.0	-0.6	0.6	0.8	2.0	0.4
Osteoporosis (self-reported)	0.8	1.0	2.2	-0.2	1.3	1.5	1.1	-0.1
Medication: Lisinopril	0.8	1.0	2.1	-1.2	-0.5	-1.5	0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	1.9	-0.2	-1.4	-1.3	1.2	0.6
Leg fat mass (left)	0.8	3.1	6.2	-0.8	-0.7	-2.1	2.5	2.0
Bipolar Disorder or Schizophrenia	0.7	1.8	4.4	-2.1	-2.1	-0.5	0.0	0.0
Age at First Birth	0.7	1.0	2.4	-0.8	-0.3	-1.1	-1.5	-0.8
Hypothyroidism (self reported)	0.7	1.7	3.5	-1.8	-1.9	-1.2	0.2	-0.2
Respiratory disease	0.7	1.6	3.9	-0.2	0.7	-0.8	2.0	1.7
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.7	0.6	-0.0	0.3	-1.6	-1.4
Hip circumference	0.7	2.8	8.6	0.1	0.8	-1.0	2.9	2.0
Happiness	0.7	0.9	3.5	-0.1	1.9	0.7	-0.1	0.6
Hair/balding pattern: Pattern 4	0.7	1.6	3.1	0.1	-1.3	-0.4	-1.8	-1.8
Medication for pain relief, constipation, heartburn	0.7	1.2	3.0	0.0	-0.0	-0.4	-1.7	-1.7
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.8	-0.3	-1.1	1.3	0.6
Comparative height size at age 10	0.7	3.8	8.4	-1.2	0.5	-1.8	2.9	2.4
Age at last live birth	0.7	1.0	1.8	-0.6	-0.2	-1.3	-1.0	-1.4
Long-standing illness, disability or infirmity	0.7	1.1	2.0	1.3	1.0	0.7	0.6	1.4
Medication for cholesterol	0.7	1.0	3.9	-0.9	0.1	-0.3	2.0	0.4
Medication: Aspirin	0.7	0.9	1.8	0.2	-0.5	-1.0	1.3	1.2
Mother’s age at death	0.7	0.9	2.0	-1.0	0.4	0.9	-0.7	1.4
Pack years of smoking	0.7	1.1	2.1	-0.9	-1.4	-0.7	-1.0	-1.0
Blood Eosinophil Count	0.6	4.5	7.3	1.1	-2.2	1.8	-2.7	-2.4
Waist Hip Ratio (WHR)	0.6	2.9	9.2	-0.7	-3.0	-1.8	0.5	1.1
Number of treatments/medications taken	0.6	1.0	3.1	-0.5	-0.4	-0.9	1.8	0.9
Hearing difficulty/problems: Yes	0.6	1.0	2.3	0.7	1.4	-0.2	0.4	1.5
Severe depression (siblings)	0.6	0.6	1.3	0.5	1.1	-0.7	0.8	0.8
Pack years adult smoking proportion	0.6	0.8	1.7	-0.8	-1.3	-0.8	-0.6	-0.9
Waist circumference	0.6	2.3	4.5	-0.5	-0.6	-1.8	2.1	1.8
Weight	0.6	2.8	5.3	-0.7	-0.5	-2.2	2.3	1.7
Hair/balding pattern: Pattern 3	0.6	1.0	1.7	-0.0	1.3	1.0	1.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.2	1.2	1.1	0.5	0.3	-1.5
Gout (self-reported)	0.6	0.8	2.1	1.4	0.4	-1.3	-0.3	0.4
Wheeze or whistling in the chest in last year	0.6	1.1	3.5	0.7	0.9	0.9	0.1	-1.9
Neck or shoulder pain in last month	0.6	0.9	1.5	-1.0	-1.1	-1.2	-0.2	0.7
Whole body fat mass	0.6	2.3	4.5	-0.3	-0.8	-2.1	1.9	1.6
Alcohol intake frequency.	0.6	1.3	3.4	0.0	-1.0	0.0	-1.5	-1.8
Number of full sisters	0.6	0.7	2.3	-0.6	-1.5	-0.9	-0.2	-0.2
Had major operations	0.6	0.7	1.6	-0.3	0.9	0.3	0.9	1.3
Mood swings	0.6	1.0	2.9	0.7	0.7	1.7	0.9	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	-0.3	0.9	0.6	-0.7	-1.3
Medication: Blood pressure	0.6	1.1	4.1	0.0	-0.8	-0.7	-2.0	0.4
Ever smoked	0.6	1.0	3.9	-2.0	0.2	-0.4	0.6	0.7
Leg fat percentage (left)	0.6	2.3	4.0	-0.9	-0.7	-1.6	1.8	2.0
Cholesterol lowering medication	0.6	0.9	1.8	1.2	1.4	0.8	-0.6	-0.0
Schizophrenia (2014)	0.5	1.1	3.6	-0.4	-0.2	0.6	-1.2	-1.9
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	1.2	0.9	0.5	-0.6	-0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.8	0.3	0.7	-0.6	0.9	0.8
Diabetes (father)	0.5	0.6	1.7	0.5	-0.6	-1.3	0.3	0.8
Hand grip strength (right)	0.5	1.3	2.4	-0.4	-1.2	-1.2	1.5	1.1
Taking other prescription medications	0.5	0.7	1.4	-0.7	0.2	-1.1	1.2	0.5
Qualifications: CSEs or equivalent	0.5	0.6	0.9	-1.0	-0.9	-0.9	-0.3	0.7
Body mass index (BMI)	0.5	2.0	3.8	-0.9	-0.8	-1.7	1.9	1.4
Hearing difficulty/problems with background noise	0.5	0.8	1.5	-0.9	1.1	-0.5	1.2	0.3
Impedance of arm (right)	0.5	2.4	8.0	1.3	-0.3	0.2	-2.8	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	-0.1	-0.8	0.0	-1.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.1	0.6	1.0	-0.1	1.1	0.9
Medication: Lansoprazole	0.5	0.5	1.3	-0.7	-0.2	0.4	1.2	0.8
Prospective memory result	0.5	0.6	1.6	-0.8	-0.8	-0.7	-0.0	1.3
Length of working week for main job	0.5	0.5	1.6	-0.4	-0.4	-0.5	1.3	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.4	0.5	0.9	1.5	0.2	0.2
Loud music exposure frequency	0.5	0.6	1.4	-0.4	-0.2	-0.7	-1.2	-0.9
High blood pressure (siblings)	0.5	0.8	2.0	0.9	1.4	0.9	-0.0	-0.1
Body fat percentage	0.5	1.9	4.8	-0.6	-1.1	-2.2	1.1	1.4
Comparative body size at age 10	0.5	1.3	2.5	-1.2	-1.2	-0.8	-0.7	-1.6
Overall health rating	0.5	1.0	2.5	1.6	0.0	1.0	0.7	0.9
Diabetes diagnosed by doctor	0.5	0.8	1.6	-1.2	-1.3	-0.5	0.6	0.5
Mineral and other dietary supplements	0.5	0.7	1.9	1.4	-0.9	0.3	-0.9	-0.0
Osteoarthritis (self-reported)	0.5	0.6	1.1	-0.5	1.0	-1.1	-0.3	0.7
Arm fat mass (left)	0.5	2.1	3.8	-0.4	-0.8	-1.9	2.0	1.5
Financial situation satisfaction	0.5	0.6	1.4	-1.2	-0.6	-0.9	-0.5	-0.4
Medication: Atorvastatin	0.5	0.6	1.8	0.4	1.4	0.3	0.1	1.0
Unable to work because of sickness or disability	0.5	0.6	1.8	-0.6	-0.1	-1.3	0.8	0.7
Commuting to job workplace: Cycle	0.5	0.6	2.3	-0.1	0.7	-0.2	1.5	0.4
Pain experienced in last month	0.5	0.9	2.5	1.0	0.9	1.6	-0.1	0.3
Alzheimer’s Disease (in father)	0.4	0.4	0.8	-0.7	-0.9	-0.2	0.8	0.1
Irritable Bowel Disease (IBD)	0.4	1.1	2.0	1.4	1.2	1.2	-0.4	0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.4	1.0	1.5	-0.5	0.8	0.9
Prostate Cancer	0.4	0.5	1.1	0.0	0.4	0.7	0.9	1.0
Blood White Count	0.4	2.8	9.9	0.6	-0.6	1.4	-1.2	-3.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.0	-0.7	0.6	0.0	1.2	1.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.1	-0.9	-0.6	-0.7	0.6
Medication: Atenolol	0.4	0.5	1.8	-0.6	-0.4	0.2	0.6	1.3
Trunk fat mass	0.4	1.9	4.7	-0.5	-0.7	-2.2	1.6	1.2
Had menopause	0.4	0.5	1.1	0.4	1.0	0.6	-1.1	-0.1
Qualifications: None of the above	0.4	0.9	1.8	-1.3	-0.5	0.3	1.4	0.7
Arm fat percentage (right)	0.4	1.4	3.2	-0.4	-0.9	-1.8	1.1	1.2
Trunk fat-free mass	0.4	2.1	7.7	-0.3	0.7	-0.7	2.8	1.3
Time employed in main current job	0.4	0.4	1.8	0.4	0.3	-0.4	-0.0	-1.3
Impedance of arm (left)	0.4	2.1	7.6	1.1	-0.2	-0.1	-2.8	-1.2
Arm fat mass (right)	0.4	1.8	3.5	-0.4	-0.8	-1.9	1.7	1.5
Trunk predicted mass	0.4	2.0	7.5	-0.3	0.6	-0.7	2.7	1.3
Peak expiratory flow (PEF)	0.4	1.0	3.9	0.2	0.4	-0.1	0.9	2.0
Medication: Paracetamol	0.4	0.6	1.2	-0.9	-1.1	-0.8	0.2	0.7
Medication: Amlodipine	0.4	0.5	1.3	-0.8	-1.2	-0.1	-0.9	0.0
Arm fat-free mass (right)	0.4	1.9	6.6	-0.6	0.3	-1.0	2.6	1.2
Number of full brothers	0.4	0.5	1.4	-0.7	-0.5	-0.2	1.2	0.3
Age at first live birth	0.4	0.7	1.5	-0.4	0.4	-1.1	-0.9	-1.2
Eye problems/disorders: None of the above	0.4	0.4	1.5	-0.5	-0.1	-0.6	0.3	1.2
Migraine (self-reported)	0.4	0.5	1.7	-0.2	0.8	0.0	-1.3	-0.3
Arm predicted mass (right)	0.4	1.9	6.7	-0.5	0.4	-0.9	2.6	1.2
Knee pain experienced in last month	0.4	0.7	1.4	0.1	1.1	0.7	-1.2	-0.4
Illnesses of father: Heart disease	0.4	0.6	2.4	0.3	1.5	0.5	0.3	-0.1
Arm fat percentage (left)	0.4	1.6	3.7	-0.5	-0.8	-1.9	1.3	1.2
Qualifications: nursing, teaching	0.4	0.7	2.9	1.7	0.2	0.4	0.3	0.6
Smoking status: Current	0.4	0.6	1.3	-0.6	-0.7	-0.0	-1.1	-1.0
Medication: Paracetamol	0.4	0.7	1.6	-1.2	-0.9	-0.4	0.6	0.8
Basal metabolic rate	0.4	2.1	6.8	-0.3	0.1	-1.3	2.6	1.3
Age started oral contraceptive pill	0.4	0.5	1.6	0.2	-1.2	0.1	-0.9	-0.2
Diastolic blood pressure, automated reading	0.4	1.3	2.9	-0.8	-0.5	-1.7	0.2	1.6
Alcohol drinker status: Previous	0.4	0.4	1.1	0.2	0.7	1.0	-0.0	-0.7
Arm predicted mass (left)	0.4	1.9	6.7	-0.5	0.2	-0.9	2.6	1.3
Reaction Time	0.3	0.5	1.1	-0.1	1.1	1.0	0.6	0.1
Breast Cancer	0.3	0.8	1.6	-1.1	-0.5	-1.3	0.1	1.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.8	1.3	-0.1	-0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.5	1.6	-1.3	-0.8	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.3	0.4	1.3	0.7	0.5	1.1	0.0	0.0
BMI	0.3	1.8	3.7	-0.8	-1.1	-1.6	1.9	0.8
Height	0.3	5.3	11.3	1.4	2.1	0.4	2.9	3.4
Cardiovascular Disease	0.3	1.1	5.0	-0.0	-0.5	0.0	0.5	2.2
Chronotype (morning person)	0.3	0.8	2.6	0.9	0.3	1.6	-0.5	0.4
Hand grip strength (left)	0.3	0.7	1.6	-0.9	-0.6	-1.3	0.9	0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.6	0.7	-0.8	-0.5	-0.1	0.7
Leg fat-free mass (left)	0.3	1.6	4.8	-0.6	-0.1	-1.5	2.2	0.7
Trunk fat percentage	0.3	1.3	4.4	-0.4	-1.0	-2.1	0.7	0.6
Current tobacco smoking	0.3	0.6	1.2	-0.5	-0.5	0.0	-1.1	-1.1
Leg predicted mass (left)	0.3	1.5	4.5	-0.7	-0.1	-1.5	2.1	0.6
Alcohol usually taken with meals	0.3	0.5	0.8	-0.2	0.9	-0.8	-0.8	-0.5
Heart attack	0.3	0.4	1.2	-0.9	-0.1	0.2	1.1	-0.1
Breastfed as a baby	0.3	0.4	1.0	0.1	0.6	0.1	1.0	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.2	-0.1	-0.9	0.5	0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.9	0.2	-0.6	0.9	0.5	-0.3
Headache pain in last month	0.3	0.6	1.8	-0.6	-1.4	-0.8	0.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.6	0.3	0.6	0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	-1.2	-0.4	-0.4	0.1	-0.4
Family relationship satisfaction	0.3	0.4	1.2	-0.6	1.1	-0.4	0.3	0.4
Hypertension (Self-reported)	0.3	0.9	3.3	-0.6	-0.7	-0.3	0.0	1.8
Whole body fat-free mass	0.3	1.9	7.1	-0.3	0.4	-1.0	2.7	1.1
Average weekly red wine intake	0.3	0.5	1.2	-0.3	1.0	1.1	0.1	0.2
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.3	0.6	-0.4	0.9	0.2
Eye problems/disorders: Cataract	0.3	0.4	1.1	0.0	-0.2	-0.6	-0.5	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	-0.8	0.4	-0.4	0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.2	1.5	-0.1	0.5	-0.3	-0.6
Whole body water mass	0.3	1.9	6.6	-0.5	0.4	-1.1	2.6	1.1
Wears glasses or contact lenses	0.3	0.3	0.8	0.8	0.9	-0.2	-0.3	-0.2
Arm fat-free mass (left)	0.3	1.6	5.2	-0.5	-0.0	-1.1	2.3	1.1
Ever depressed for a whole week	0.3	0.4	1.8	0.4	1.3	0.2	-0.2	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.0	0.6	-0.0	0.3	-0.8	-1.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	-1.1	-0.4	-0.0	0.6	-0.4
Impedance of whole body	0.3	1.7	6.0	1.2	-0.5	0.0	-2.4	-0.8
Depression (Nagel 2018)	0.2	0.3	1.2	-0.3	0.1	1.1	-0.0	-0.2
Ovarian Cancer	0.2	0.2	1.0	-0.0	-0.2	-1.0	0.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	0.8	0.7	-0.3	0.0	0.0
Blood Red Count	0.2	1.5	5.5	1.0	0.9	2.3	0.4	-0.3
Smoking Status	0.2	0.5	0.8	-0.6	0.9	0.6	0.9	-0.2
Lung FEV1/FVC ratio	0.2	1.1	2.1	-1.4	-1.4	-0.6	-0.4	1.0
Lung FVC	0.2	1.2	3.9	0.3	1.0	2.0	-0.3	-0.9
Hair Pigment	0.2	6.2	16.6	-1.2	-1.1	-3.0	1.7	4.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.6	0.6	0.5	0.2	0.1
Age when periods started (menarche)	0.2	0.5	1.6	0.1	-1.2	-0.8	-0.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.6	0.0	-0.8	0.3	0.4
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.3	0.9	-0.2	0.6	-0.1
High blood pressure	0.2	0.7	2.3	-0.7	-0.3	-0.4	0.5	1.5
Forced vital capacity (FVC)	0.2	0.6	1.8	0.8	1.3	-0.1	0.9	0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	0.4	0.6	-0.2	-0.6	-0.7
Falls in the last year	0.2	0.3	0.8	0.4	0.4	0.2	-0.9	0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	1.4	0.7	-0.2	0.1	1.2	0.5
Birth weight of first child	0.2	0.3	1.1	0.3	-1.1	0.1	-0.2	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.3	0.0	-0.4	-1.1	0.1	-0.1
Health satisfaction	0.2	0.2	1.1	0.2	0.1	-0.2	0.2	1.0
Shortness of breath walking on level ground	0.2	0.3	0.5	0.3	-0.7	-0.1	-0.7	-0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	0.0	-0.2	0.5	-0.8	0.6
Mean time to correctly identify matches	0.2	0.4	0.6	-0.8	0.8	0.1	0.7	0.7
Leg pain on walking	0.2	0.3	1.1	1.1	-0.4	0.1	0.1	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.4	-0.6	0.5	0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	-0.6	-0.7	-0.6	-0.4	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.7	-0.1	-0.8	-0.1	0.6	-0.3
Leg fat-free mass (right)	0.2	1.1	4.2	-0.2	0.3	-1.1	2.0	0.4
Breast cancer (self-reported)	0.2	0.3	0.8	0.3	-0.5	-0.9	-0.5	0.1
Illnesses of father: None of the above (group 1)	0.2	0.3	1.1	0.0	-0.0	0.0	0.6	1.0
Leg predicted mass (right)	0.2	1.1	3.8	-0.3	0.2	-1.1	2.0	0.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.5	-0.3	0.5	-0.2	0.2	1.2
High cholesterol (Self-reported)	0.2	0.4	1.2	-0.3	-0.3	-0.1	-1.1	0.6
HDL Cholesterol	0.1	0.2	0.7	0.4	-0.8	-0.0	0.0	-0.2
Ulcerative Colitis	0.1	0.2	0.9	-0.0	0.0	1.0	0.0	0.0
Heel T-Score	0.1	1.1	4.1	0.7	0.6	2.0	0.2	-0.6
Systolic Blood Pressure	0.1	0.5	1.1	-0.4	-0.4	-0.7	-0.6	1.1
Tanning	0.1	1.5	5.1	0.3	2.2	1.4	0.7	-0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.5	-0.4	0.4	0.0	-0.3
Systolic blood pressure, automated reading	0.1	0.2	0.7	0.2	0.4	0.2	0.0	0.8
Impedance of leg (right)	0.1	0.7	1.4	0.4	-1.0	-0.4	-1.2	0.8
Sitting height	0.1	1.0	2.6	0.1	0.1	-1.6	1.4	0.9
Impedance of leg (left)	0.1	0.6	1.4	0.8	-0.8	-0.2	-1.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.4	0.5	0.5	0.1	-0.1
Financial difficulties in last 2 years	0.1	0.2	0.7	-0.1	0.2	-0.3	0.2	-0.9
Mouth/teeth dental problems	0.1	0.2	0.3	-0.1	0.6	-0.3	-0.6	0.3
Medication: Simvastatin	0.1	0.2	0.6	-0.8	0.1	-0.1	-0.3	-0.2
Fluid intelligence score	0.1	0.3	0.5	0.5	0.7	-0.4	0.4	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	0.9	0.4	0.2	0.4	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	0.7	0.8	0.1	0.8	0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	0.6	0.9	0.3	0.5	-0.1
Standing height	0.1	1.0	1.9	0.3	0.6	-1.0	1.4	1.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	0.2	0.4	-0.8	0.7	-0.3
Chest pain or discomfort	0.1	0.2	0.8	0.1	-0.1	0.9	0.4	-0.1
Loneliness, isolation	0.1	0.1	0.3	0.1	-0.4	0.2	-0.3	-0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.5	0.0	0.7	0.1	0.3	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.1	0.3	0.5	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.1	0.2	0.4	-0.2	-0.3	0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	0.2	-0.2	-0.5	0.3	-0.2
Qualifications: College or University degree	0.0	0.1	0.5	0.1	0.1	-0.7	0.1	0.0
Ever had bowel cancer screening	0.0	0.0	0.1	0.3	-0.2	0.1	-0.0	-0.3

Hub : Genes

SLC7A5

Models

Trait associations