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chr17:16,256,240-21,062,061

Best TWAS P=3.23e-23 · Best GWAS P=2.21e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
47	METSIM	Adipose	RP11-78O7.2	0.07	0.07	lasso	15	0.06	7.8e-10	9.9	-9.9	3.2e-23	-1.00	0.01	0.99	TRUE
77	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ALKBH5	0.22	0.10	blup	66	0.12	1.4e-05	-6.4	7.2	4.2e-13	-0.04	0.01	0.94	TRUE
46	METSIM	Adipose	MPRIP	0.04	0.04	enet	5	0.04	1.2e-06	-6.1	6.2	4.7e-10	-0.03	0.00	0.99	TRUE
53	YFS	Blood	AKAP10	0.37	0.50	lasso	6	0.50	1.2e-194	9.8	9.9	3.9e-23	0.99	0.01	0.99	FALSE
32	GTEx	Nerve Tibial	RP11-78O7.2	0.09	0.07	lasso	2	0.06	2.6e-05	9.9	-9.9	4.0e-23	-1.00	0.02	0.98	FALSE
27	GTEx	Esophagus Muscularis	RP11-78O7.2	0.08	0.09	lasso	1	0.08	1.9e-05	9.9	-9.9	4.1e-23	-1.00	0.02	0.98	FALSE
4	GTEx	Adipose Subcutaneous	RP11-78O7.2	0.08	0.06	lasso	5	0.07	3.2e-06	9.8	-9.1	1.3e-19	-0.93	0.01	0.98	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	AKAP10	0.05	0.00	blup	44	0.00	1.2e-01	9.2	8.8	1.5e-18	0.86	0.01	0.30	FALSE
23	GTEx	Esophagus Mucosa	RP11-78O7.2	0.06	0.07	lasso	2	0.06	4.7e-05	-7.8	-8.3	1.5e-16	-0.78	0.03	0.94	FALSE
19	GTEx	Colon Transverse	SPECC1	0.10	0.06	lasso	3	0.10	1.5e-05	7.7	8.2	3.0e-16	0.79	0.10	0.87	FALSE
45	METSIM	Adipose	LGALS9B	0.08	0.04	blup	176	0.06	8.6e-09	-6.0	-7.9	2.8e-15	-0.74	0.58	0.42	FALSE
6	GTEx	Adipose Visceral Omentum	SPECC1	0.08	0.01	enet	29	0.02	2.3e-02	-6.6	7.6	4.0e-14	0.61	0.18	0.19	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-78O7.2	0.08	0.03	enet	7	0.06	4.3e-04	2.8	-7.4	1.8e-13	-0.83	0.03	0.90	FALSE
25	GTEx	Esophagus Muscularis	SPECC1	0.14	0.04	lasso	3	0.03	5.3e-03	7.9	-7.2	8.0e-13	-0.64	0.32	0.18	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	ALKBH5	0.09	0.02	lasso	3	0.03	1.2e-04	-5.9	7.1	1.6e-12	-0.08	0.05	0.83	FALSE
18	GTEx	Cells Transformed fibroblasts	RP11-78O7.2	0.08	0.00	enet	17	0.00	2.2e-01	9.2	-6.8	1.1e-11	-0.68	0.02	0.85	FALSE
26	GTEx	Esophagus Muscularis	LLGL1	0.19	0.06	lasso	5	0.06	1.1e-04	-6.4	-6.7	1.7e-11	0.03	0.01	0.98	FALSE
54	YFS	Blood	LLGL1	0.21	0.12	lasso	9	0.14	1.9e-43	-5.0	6.6	3.1e-11	-0.03	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	ALKBH5	0.19	0.02	blup	63	0.04	3.4e-05	-6.0	6.6	4.9e-11	-0.08	0.02	0.96	FALSE
10	GTEx	Adrenal Gland	CTD-2303H24.2	0.31	0.05	lasso	7	0.12	3.6e-05	-4.2	-6.5	5.9e-11	-0.04	0.16	0.42	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	ALKBH5	0.06	0.02	blup	63	0.02	7.2e-06	-5.6	6.5	7.4e-11	-0.07	0.07	0.70	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	CTD-2303H24.2	0.33	0.20	lasso	3	0.34	6.0e-13	5.5	-6.4	1.3e-10	-0.02	0.58	0.40	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AKAP10	0.04	0.03	lasso	1	0.03	1.9e-04	-6.4	6.4	1.7e-10	0.66	0.47	0.23	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYO15A	0.04	0.02	lasso	3	0.02	2.5e-03	-6.4	6.4	1.7e-10	-0.02	0.01	0.90	FALSE
36	GTEx	Spleen	AKAP10	0.25	0.07	lasso	5	0.14	2.5e-04	9.4	6.4	2.0e-10	0.69	0.04	0.82	FALSE
9	GTEx	Adrenal Gland	MIEF2	0.34	0.19	lasso	7	0.26	8.1e-10	-4.1	6.3	3.4e-10	-0.03	0.34	0.66	FALSE
64	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TOP3A	0.07	0.02	blup	48	0.02	1.3e-03	-5.9	6.3	3.9e-10	0.03	0.00	0.97	FALSE
87	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLII	0.05	0.04	blup	47	0.03	1.7e-03	-5.9	6.2	4.0e-10	-0.01	0.02	0.70	FALSE
41	GTEx	Vagina	SHMT1	0.38	0.02	lasso	4	-0.01	6.6e-01	-5.9	-6.2	4.9e-10	-0.01	0.02	0.60	FALSE
67	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TOP3A	0.11	0.01	enet	10	0.05	5.8e-04	-5.9	6.2	5.7e-10	0.02	0.01	0.80	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	DRG2	0.09	0.02	blup	54	0.03	3.8e-04	3.0	6.2	5.8e-10	-0.01	0.01	0.77	FALSE
20	GTEx	Colon Transverse	RP11-78O7.2	0.17	0.11	enet	22	0.14	4.1e-07	9.8	-6.2	7.2e-10	-0.79	0.02	0.98	FALSE
37	GTEx	Spleen	CTD-2303H24.2	0.32	0.02	enet	15	0.12	5.2e-04	-5.9	-6.2	7.4e-10	0.00	0.07	0.53	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMCR7	0.07	0.04	blup	33	0.03	3.0e-04	-5.9	6.1	8.4e-10	0.03	0.01	0.93	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLII	0.03	0.01	lasso	4	0.00	8.4e-02	-6.9	6.1	9.2e-10	0.00	0.00	0.77	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	SMCR7	0.05	0.03	enet	7	0.05	3.7e-06	-5.9	6.1	9.7e-10	0.03	0.02	0.97	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLII	0.04	0.01	blup	47	0.02	7.2e-05	-5.9	6.1	1.0e-09	0.03	0.06	0.45	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SPECC1	0.24	0.21	lasso	3	0.26	4.2e-31	-5.6	6.1	1.1e-09	0.68	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMCR7	0.19	0.03	blup	33	0.06	4.5e-04	-4.0	6.1	1.2e-09	-0.02	0.02	0.50	FALSE
42	GTEx	Whole Blood	ALKBH5	0.08	0.00	enet	26	0.00	3.0e-01	3.7	6.0	1.7e-09	-0.03	0.03	0.54	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	FLII	0.04	0.01	blup	47	0.03	5.1e-04	-5.9	6.0	1.8e-09	0.03	0.02	0.84	FALSE
11	GTEx	Artery Aorta	LLGL1	0.34	0.05	lasso	9	0.12	4.0e-07	-5.9	-6.0	2.0e-09	0.09	0.13	0.77	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYTSB	0.03	0.03	lasso	4	0.02	2.8e-05	-5.9	6.0	2.0e-09	0.59	0.81	0.17	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	SPECC1	0.12	0.13	lasso	2	0.11	1.6e-04	-6.0	6.0	2.1e-09	0.59	0.25	0.30	FALSE
35	GTEx	Small Intestine Terminal Ileum	CTD-2303H24.2	0.38	0.28	lasso	9	0.26	1.7e-06	-6.0	-6.0	2.4e-09	0.03	0.01	0.96	FALSE
38	GTEx	Testis	USP32P3	0.11	0.19	lasso	3	0.16	8.6e-08	-5.5	-5.9	4.3e-09	-0.55	0.82	0.16	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	USP32P2	0.74	0.61	enet	18	0.65	4.4e-110	5.5	-5.9	4.4e-09	-0.04	0.97	0.03	FALSE
29	GTEx	Heart Left Ventricle	CTD-2303H24.2	0.24	0.04	lasso	6	0.10	4.3e-06	-5.9	-5.7	1.0e-08	-0.03	0.39	0.55	FALSE
8	GTEx	Adipose Visceral Omentum	CTD-2303H24.2	0.35	0.10	enet	14	0.23	2.8e-12	-5.9	-5.7	1.1e-08	-0.04	0.13	0.87	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOP3A	0.05	0.02	enet	8	0.03	1.2e-07	3.1	5.7	1.1e-08	0.03	0.02	0.97	FALSE
16	GTEx	Cells Transformed fibroblasts	ALKBH5	0.16	0.05	lasso	7	0.10	9.2e-08	3.7	5.7	1.2e-08	-0.11	0.97	0.02	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	SHMT1	0.15	0.00	lasso	4	0.00	2.5e-01	-6.8	5.7	1.2e-08	-0.03	0.03	0.70	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	TOP3A	0.15	0.06	lasso	3	0.09	2.9e-09	-5.0	5.7	1.2e-08	0.00	0.25	0.70	FALSE
28	GTEx	Esophagus Muscularis	CTD-2303H24.2	0.25	0.09	lasso	5	0.16	8.4e-10	5.5	-5.6	1.7e-08	-0.02	0.21	0.78	FALSE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	TOP3A	0.08	0.04	enet	8	0.07	3.7e-08	3.3	5.6	1.8e-08	0.05	0.06	0.94	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	SHMT1	0.26	0.10	enet	38	0.09	6.8e-12	5.5	5.6	2.1e-08	0.01	0.97	0.03	FALSE
78	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLII	0.20	0.08	blup	54	0.13	7.0e-06	-2.0	5.5	3.3e-08	0.04	0.04	0.68	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CCDC144B	0.21	0.05	enet	30	0.16	1.5e-18	-2.8	-5.5	3.5e-08	-0.04	0.68	0.32	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	LLGL1	0.06	0.04	enet	2	0.04	3.6e-05	-5.0	-5.5	3.5e-08	0.08	0.25	0.04	FALSE
24	GTEx	Esophagus Mucosa	CTD-2303H24.2	0.21	0.09	enet	29	0.17	2.4e-11	5.5	-5.5	4.0e-08	-0.04	0.18	0.82	FALSE
33	GTEx	Nerve Tibial	CTD-2303H24.2	0.23	0.08	enet	15	0.18	9.4e-13	5.5	-5.5	4.1e-08	-0.03	0.82	0.18	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLII	0.04	0.02	blup	48	0.03	2.2e-03	-6.0	5.5	4.3e-08	0.01	0.02	0.66	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYO15A	0.03	0.02	blup	79	0.02	9.4e-04	-3.7	5.5	4.3e-08	0.03	0.02	0.78	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ALKBH5	0.05	0.02	lasso	2	0.03	3.1e-03	3.9	5.5	4.7e-08	-0.05	0.03	0.51	FALSE
79	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMCR7	0.13	0.05	enet	11	0.08	4.3e-04	3.2	5.5	4.9e-08	0.05	0.01	0.79	FALSE
39	GTEx	Testis	CTD-2303H24.2	0.50	0.26	lasso	17	0.36	1.1e-16	5.5	-5.4	6.5e-08	-0.04	0.94	0.06	FALSE
44	GTEx	Whole Blood	CTD-2303H24.2	0.04	0.02	lasso	4	0.04	8.4e-05	-5.9	-5.4	7.1e-08	-0.01	0.13	0.63	FALSE
12	GTEx	Artery Aorta	CTD-2303H24.2	0.39	0.12	enet	37	0.27	3.7e-15	5.5	-5.4	7.8e-08	-0.06	0.43	0.56	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	ALKBH5	0.07	0.05	blup	63	0.06	2.0e-05	3.9	5.3	8.9e-08	-0.06	0.05	0.93	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLII	0.08	0.02	enet	6	0.04	1.9e-05	3.0	5.3	9.7e-08	0.02	0.07	0.50	FALSE
66	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLII	0.16	0.00	enet	6	0.06	1.4e-04	-4.1	5.3	1.1e-07	0.05	0.02	0.34	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	SPECC1	0.17	0.27	lasso	11	0.26	1.3e-33	5.1	5.3	1.3e-07	0.38	1.00	0.00	FALSE
40	GTEx	Thyroid	CTD-2303H24.2	0.20	0.14	enet	8	0.13	1.9e-10	-2.8	-5.3	1.4e-07	-0.05	0.90	0.10	FALSE
48	NTR	Blood	SPECC1	0.06	0.02	bslmm	279	0.02	1.1e-07	-8.2	5.3	1.4e-07	0.43	0.98	0.01	FALSE
17	GTEx	Cells Transformed fibroblasts	RP11-258F1.1	0.18	0.12	lasso	3	0.15	1.7e-11	3.7	5.2	1.5e-07	-0.10	0.88	0.12	FALSE
34	GTEx	Skin Sun Exposed Lower leg	CTD-2303H24.2	0.24	0.08	enet	20	0.13	3.9e-11	-2.8	-5.2	1.6e-07	-0.07	0.98	0.02	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	NOS2P3	0.30	0.47	lasso	7	0.53	3.4e-80	5.1	-5.2	1.6e-07	-0.32	1.00	0.00	FALSE
31	GTEx	Muscle Skeletal	CTD-2303H24.2	0.23	0.11	enet	23	0.17	5.2e-16	5.5	-5.2	1.7e-07	-0.01	0.85	0.15	FALSE
13	GTEx	Brain Cortex	CTD-2303H24.2	0.34	0.08	enet	42	0.15	5.3e-05	-3.2	-5.2	2.0e-07	-0.03	0.03	0.69	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CTD-2303H24.2	0.41	0.02	enet	30	0.14	7.5e-05	5.5	-5.2	2.0e-07	-0.08	0.10	0.10	FALSE
30	GTEx	Lung	CTD-2303H24.2	0.45	0.12	lasso	6	0.27	1.3e-20	-2.8	-5.2	2.4e-07	-0.03	0.98	0.02	FALSE
43	GTEx	Whole Blood	COPS3	0.14	0.17	lasso	6	0.16	1.3e-14	-4.7	-5.2	2.4e-07	0.02	0.58	0.41	FALSE
5	GTEx	Adipose Subcutaneous	CTD-2303H24.2	0.16	0.11	enet	15	0.18	2.4e-14	5.5	-5.2	2.5e-07	-0.04	0.93	0.07	FALSE
62	The Cancer Genome Atlas	Glioblastoma Multiforme	FLCN	0.15	0.15	lasso	2	0.13	1.0e-04	4.8	-5.2	2.5e-07	0.01	0.01	0.83	FALSE
85	The Cancer Genome Atlas	Soft Tissue Sarcoma	TOP3A	0.08	0.03	enet	24	0.04	1.6e-03	3.1	5.1	2.8e-07	-0.02	0.02	0.77	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMCR7	0.07	0.02	lasso	3	0.01	8.3e-03	2.7	5.1	2.9e-07	-0.06	0.02	0.69	FALSE
65	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLCN	0.03	0.04	enet	8	0.02	3.9e-03	4.8	-5.1	3.0e-07	0.02	0.01	0.97	FALSE