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chr17:6,544,116-8,516,435

Best TWAS P=3.43e-24 · Best GWAS P=8.22e-24 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ATP1B2	0.13	0.01	blup	42	0.02	6.3e-02	-4.34	10.1	3.4e-24	0.12	0.01	0.15	TRUE
18	METSIM	Adipose	ATP1B2	0.07	0.04	bslmm	494	0.03	1.2e-05	7.79	9.5	2.0e-21	0.11	0.98	0.00	TRUE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ATP1B2	0.06	0.01	blup	39	0.02	4.3e-03	7.70	8.9	7.5e-19	0.14	0.04	0.59	TRUE
35	The Cancer Genome Atlas	Thyroid Carcinoma	TRAPPC1	0.12	0.02	lasso	4	0.05	2.6e-05	8.91	-7.8	4.3e-15	-0.66	0.00	1.00	TRUE
12	GTEx	Small Intestine Terminal Ileum	CHRNB1	0.43	-0.01	lasso	9	0.00	2.9e-01	-2.78	-6.7	1.8e-11	-0.06	0.06	0.06	TRUE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TNFSF12-TNFSF13	0.06	0.00	blup	58	0.01	3.4e-02	8.68	6.4	1.3e-10	0.09	0.00	0.77	TRUE
7	GTEx	Esophagus Muscularis	CHRNB1	0.35	0.19	lasso	7	0.28	1.9e-17	5.30	-6.3	3.4e-10	-0.10	1.00	0.00	TRUE
26	YFS	Blood	ACAP1	0.33	0.21	enet	34	0.29	1.1e-96	-5.15	6.2	7.3e-10	0.05	1.00	0.00	TRUE
6	GTEx	Cells Transformed fibroblasts	TNFSF12	0.25	0.22	lasso	8	0.20	7.4e-15	-5.82	-6.0	1.5e-09	-0.16	1.00	0.00	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	WRAP53	0.06	0.08	lasso	3	0.06	6.4e-08	4.26	-5.8	5.0e-09	-0.08	1.00	0.00	TRUE
20	METSIM	Adipose	TMEM88	0.09	0.02	bslmm	500	0.03	4.6e-05	6.40	5.8	8.0e-09	0.11	0.63	0.03	TRUE
21	NTR	Blood	KDM6B	0.05	0.05	bslmm	499	0.05	8.8e-15	4.90	5.2	1.7e-07	0.59	1.00	0.00	TRUE
33	The Cancer Genome Atlas	Thyroid Carcinoma	ATP1B2	0.04	0.01	blup	40	0.01	1.4e-02	5.60	9.3	1.1e-20	0.13	0.01	0.17	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ATP1B2	0.04	0.02	blup	39	0.04	2.3e-05	7.70	9.2	2.8e-20	0.15	0.05	0.80	FALSE
4	GTEx	Adipose Subcutaneous	SNORA48	0.12	0.04	lasso	2	0.04	4.0e-04	9.00	9.1	1.2e-19	0.11	0.38	0.03	FALSE
5	GTEx	Brain Cortex	TNFSF13	0.28	0.12	lasso	5	0.09	2.1e-03	9.00	8.9	4.2e-19	0.06	0.16	0.07	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	TNFSF13	0.08	0.07	lasso	3	0.06	1.7e-08	7.94	8.4	5.1e-17	0.09	1.00	0.00	FALSE
17	METSIM	Adipose	ACAP1	0.06	0.03	blup	452	0.03	2.5e-05	2.64	7.9	3.6e-15	0.08	0.58	0.01	FALSE
11	GTEx	Skin Sun Exposed Lower leg	ATP1B2	0.08	0.01	lasso	3	0.01	4.8e-02	7.55	7.4	1.4e-13	0.10	0.38	0.02	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	TNFSF12	0.10	0.04	lasso	6	0.06	9.2e-08	-5.82	-7.3	1.9e-13	-0.19	1.00	0.00	FALSE
14	GTEx	Testis	TMEM102	0.23	0.08	lasso	6	0.07	5.1e-04	4.43	7.0	3.5e-12	0.15	0.24	0.05	FALSE
9	GTEx	Muscle Skeletal	CHRNB1	0.34	0.18	enet	35	0.24	4.9e-23	-5.66	6.9	5.8e-12	0.25	1.00	0.00	FALSE
16	GTEx	Whole Blood	TNFSF12	0.09	0.03	enet	24	0.04	1.9e-04	-5.81	-6.5	1.0e-10	-0.27	0.74	0.03	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM88	0.06	0.00	enet	10	0.01	6.5e-02	5.90	6.3	2.1e-10	0.23	0.01	0.10	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	CNTROB	0.14	0.07	blup	50	0.10	4.8e-10	1.52	-6.3	2.7e-10	-0.57	0.97	0.02	FALSE
19	METSIM	Adipose	CHD3	0.06	0.03	blup	509	0.02	6.7e-04	-0.39	-6.1	9.2e-10	-0.30	0.22	0.25	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHRNB1	0.04	0.03	blup	57	0.02	1.5e-03	-5.66	5.9	2.8e-09	0.18	0.07	0.18	FALSE
8	GTEx	Liver	CD68	0.45	-0.01	lasso	12	-0.01	4.7e-01	-4.31	-5.6	1.9e-08	-0.17	0.05	0.05	FALSE
13	GTEx	Testis	ZBTB4	0.26	0.00	enet	35	0.06	1.6e-03	8.11	-5.6	1.9e-08	-0.07	0.06	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC284023	0.10	0.07	bslmm	506	0.07	1.1e-08	5.91	5.6	2.1e-08	0.21	1.00	0.00	FALSE
10	GTEx	Nerve Tibial	CHRNB1	0.37	0.31	enet	12	0.35	9.7e-26	5.30	-5.6	2.1e-08	-0.12	1.00	0.00	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	EIF4A1	0.07	0.02	enet	6	0.02	6.4e-04	6.70	-5.4	7.1e-08	0.01	0.69	0.06	FALSE
15	GTEx	Thyroid	CHRNB1	0.11	0.03	lasso	8	0.02	7.1e-03	5.38	-5.4	7.2e-08	-0.13	0.22	0.06	FALSE
3	GTEx	Adipose Subcutaneous	CHRNB1	0.30	0.22	lasso	8	0.26	1.6e-21	5.38	-5.4	8.1e-08	-0.11	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	-3.82	-5.2	2.3e-07	-0.07	1.00	0.00	FALSE