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chr19:342,617-5,214,158

Best TWAS P=1.15e-15 · Best GWAS P=1.15e-19 conditioned to 4.28e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	GTEx	Esophagus Mucosa	ZNF554	0.25	0.24	enet	15	0.25	9.2e-17	7.68	8.0	1.1e-15	0.00	0.02	0.98	TRUE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	MKNK2	0.03	0.01	enet	10	0.02	2.0e-05	6.62	-7.5	4.9e-14	-0.38	0.05	0.39	TRUE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3D1	0.01	0.01	blup	52	0.01	5.4e-03	6.27	-7.3	2.8e-13	0.04	0.05	0.19	TRUE
42	NTR	Blood	GPX4	0.03	0.02	enet	7	0.03	2.3e-09	-4.96	-7.0	1.9e-12	0.12	0.99	0.00	TRUE
26	GTEx	Nerve Tibial	BTBD2	0.26	0.23	lasso	4	0.28	8.1e-20	6.25	-6.9	7.0e-12	-0.46	1.00	0.00	TRUE
3	GTEx	Adipose Visceral Omentum	NFIC	0.20	0.00	lasso	5	0.02	2.2e-02	-5.13	5.9	3.3e-09	-0.03	0.03	0.63	TRUE
29	GTEx	Prostate	PLIN4	0.42	0.18	lasso	7	0.01	2.1e-01	-5.39	-5.6	2.4e-08	-0.01	0.02	0.82	TRUE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF554	0.15	0.20	lasso	7	0.20	5.0e-22	7.80	7.8	4.6e-15	-0.02	0.01	0.99	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	ZNF554	0.32	0.22	lasso	4	0.23	6.8e-13	7.80	7.8	5.0e-15	-0.02	0.01	0.99	FALSE
31	GTEx	Skin Sun Exposed Lower leg	ZNF554	0.35	0.33	lasso	5	0.32	6.9e-27	7.68	7.8	5.3e-15	-0.01	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF554	0.10	0.11	lasso	8	0.10	2.9e-05	7.68	7.8	5.8e-15	-0.02	0.01	0.98	FALSE
5	GTEx	Artery Aorta	ZNF554	0.34	0.21	lasso	6	0.19	6.3e-11	7.73	7.8	6.7e-15	-0.02	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	THOP1	0.16	0.25	lasso	2	0.25	1.6e-24	7.79	7.8	8.0e-15	-0.02	0.01	0.99	FALSE
12	GTEx	Cells Transformed fibroblasts	ZNF554	0.25	0.24	lasso	3	0.23	1.9e-17	7.73	7.8	8.3e-15	-0.01	0.01	0.99	FALSE
34	GTEx	Small Intestine Terminal Ileum	ZNF554	0.37	0.54	lasso	2	0.50	7.1e-13	7.71	7.7	9.6e-15	-0.02	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	ZNF554	0.16	0.15	lasso	2	0.14	1.8e-11	7.73	7.7	1.0e-14	-0.01	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF554	0.04	0.04	lasso	2	0.03	4.9e-04	7.66	7.7	1.1e-14	-0.02	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF554	0.05	0.06	lasso	5	0.06	2.8e-07	7.78	7.7	1.2e-14	-0.02	0.01	0.99	FALSE
70	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF554	0.11	0.15	lasso	4	0.14	1.5e-10	7.68	7.7	1.6e-14	-0.02	0.01	0.99	FALSE
39	GTEx	Thyroid	THOP1	0.34	0.24	lasso	5	0.32	5.9e-25	7.54	7.7	1.8e-14	-0.02	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF554	0.02	0.02	lasso	1	0.02	1.8e-05	7.66	7.7	1.8e-14	-0.02	0.01	0.99	FALSE
36	GTEx	Testis	ZNF554	0.19	0.11	lasso	3	0.07	5.9e-04	7.68	7.7	1.9e-14	-0.02	0.02	0.96	FALSE
53	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZNF554	0.12	0.12	lasso	3	0.13	4.5e-07	7.68	7.6	2.3e-14	-0.01	0.01	0.99	FALSE
14	GTEx	Colon Transverse	ZNF554	0.27	0.27	lasso	4	0.25	2.0e-12	7.68	7.6	2.4e-14	-0.02	0.01	0.99	FALSE
15	GTEx	Colon Transverse	THOP1	0.19	0.13	lasso	4	0.15	1.7e-07	7.35	7.6	2.5e-14	-0.02	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZNF554	0.11	0.16	lasso	3	0.16	1.9e-13	7.43	7.6	2.5e-14	-0.03	0.01	0.99	FALSE
38	GTEx	Thyroid	ZNF554	0.14	0.07	lasso	3	0.05	4.8e-05	7.68	7.6	2.9e-14	-0.02	0.02	0.98	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	ZNF554	0.26	0.27	lasso	4	0.24	2.7e-08	7.54	7.6	3.8e-14	-0.02	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF554	0.16	0.18	lasso	5	0.18	6.8e-11	7.43	7.6	4.0e-14	-0.03	0.01	0.99	FALSE
28	GTEx	Pancreas	ZNF554	0.23	0.06	lasso	2	0.06	2.3e-03	7.35	7.5	5.5e-14	-0.02	0.03	0.91	FALSE
41	GTEx	Whole Blood	ZNF554	0.11	0.09	lasso	5	0.08	7.4e-08	7.68	7.5	5.5e-14	-0.02	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF554	0.07	0.09	lasso	15	0.10	3.7e-05	7.43	7.5	5.5e-14	-0.03	0.01	0.97	FALSE
63	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNF554	0.04	0.05	lasso	2	0.05	7.9e-07	7.43	7.4	1.0e-13	-0.03	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THOP1	0.04	0.05	blup	65	0.04	2.3e-05	7.73	7.4	1.9e-13	-0.03	0.01	0.99	FALSE
21	GTEx	Heart Left Ventricle	THOP1	0.17	0.09	lasso	2	0.02	2.2e-02	7.35	7.2	4.6e-13	-0.03	0.07	0.90	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF554	0.04	0.04	blup	55	0.03	4.4e-04	7.68	7.1	1.0e-12	-0.03	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3D1	0.05	0.00	blup	49	0.02	1.7e-02	6.27	-7.0	2.1e-12	0.02	0.02	0.25	FALSE
23	GTEx	Lung	ZNF554	0.27	0.10	lasso	7	0.09	1.8e-07	7.68	7.0	2.6e-12	-0.02	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP3D1	0.06	0.05	enet	7	0.04	5.7e-05	6.27	-6.7	1.8e-11	-0.01	0.80	0.10	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF554	0.12	0.08	enet	15	0.09	3.7e-09	7.73	6.7	2.5e-11	0.00	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	SGTA	0.13	0.05	lasso	5	0.07	4.6e-06	7.68	-6.7	2.9e-11	-0.01	0.03	0.97	FALSE
68	The Cancer Genome Atlas	Rectum Adenocarcinoma	ZNF554	0.19	0.00	blup	55	0.03	8.0e-02	7.43	6.5	6.8e-11	-0.04	0.01	0.75	FALSE
69	The Cancer Genome Atlas	Stomach Adenocarcinoma	AP3D1	0.09	0.07	lasso	5	0.08	3.2e-06	6.27	-6.5	1.0e-10	-0.01	0.62	0.37	FALSE
40	GTEx	Vagina	ZNF554	0.48	0.08	enet	36	0.10	3.4e-03	6.41	6.4	1.4e-10	-0.03	0.02	0.82	FALSE
22	GTEx	Lung	AP3D1	0.14	0.11	lasso	3	0.12	1.6e-09	6.27	-6.4	1.9e-10	-0.02	1.00	0.00	FALSE
4	GTEx	Artery Aorta	AP3D1	0.27	0.12	lasso	3	0.13	1.3e-07	5.90	-6.4	2.1e-10	-0.02	0.96	0.00	FALSE
16	GTEx	Esophagus Mucosa	AP3D1	0.18	0.21	lasso	3	0.21	2.4e-14	5.90	-6.3	2.9e-10	-0.02	1.00	0.00	FALSE
10	GTEx	Brain Cortex	AC006538.1	0.49	0.08	lasso	12	0.13	1.9e-04	6.04	6.3	3.6e-10	-0.02	0.10	0.34	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP3D1	0.04	0.04	lasso	2	0.04	6.1e-05	6.27	-6.3	3.7e-10	-0.01	0.26	0.36	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	AP3D1	0.05	0.05	lasso	3	0.04	1.0e-04	6.27	-6.3	3.7e-10	-0.01	0.52	0.05	FALSE
18	GTEx	Esophagus Muscularis	AP3D1	0.32	0.24	lasso	3	0.24	5.7e-15	6.27	-6.2	4.1e-10	-0.02	1.00	0.00	FALSE
6	GTEx	Artery Tibial	AP3D1	0.17	0.16	lasso	3	0.16	2.1e-12	6.27	-6.2	4.5e-10	-0.02	1.00	0.00	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	SGTA	0.10	0.08	bslmm	435	0.07	1.0e-09	6.49	-6.2	5.8e-10	0.01	0.99	0.01	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	AP3D1	0.03	0.04	lasso	1	0.03	1.4e-04	6.16	-6.2	7.4e-10	0.01	0.21	0.23	FALSE
46	YFS	Blood	ABCA7	0.20	0.04	bslmm	340	0.14	6.3e-44	3.27	-6.0	1.9e-09	0.02	1.00	0.00	FALSE
24	GTEx	Muscle Skeletal	AP3D1	0.11	0.07	lasso	5	0.07	2.9e-07	6.27	-6.0	2.0e-09	-0.02	0.96	0.00	FALSE
27	GTEx	Nerve Tibial	AC005306.3	0.16	0.05	lasso	4	0.07	6.5e-06	6.25	-6.0	2.4e-09	-0.38	0.20	0.32	FALSE
25	GTEx	Nerve Tibial	IZUMO4	0.23	0.07	lasso	6	0.14	1.9e-10	4.96	5.9	2.9e-09	-0.02	0.98	0.00	FALSE
20	GTEx	Heart Atrial Appendage	THOP1	0.21	0.01	lasso	6	0.02	6.4e-02	6.55	5.9	4.0e-09	-0.02	0.03	0.82	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	AP3D1	0.39	0.40	enet	12	0.43	8.8e-60	6.27	-5.9	4.1e-09	0.00	1.00	0.00	FALSE
13	GTEx	Colon Transverse	AP3D1	0.31	0.14	lasso	4	0.16	7.2e-08	4.96	-5.8	4.9e-09	-0.02	0.91	0.00	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	SGTA	0.09	0.06	lasso	4	0.06	2.6e-06	4.10	5.8	6.0e-09	-0.01	0.02	0.97	FALSE
8	GTEx	Artery Tibial	NFIC	0.14	0.13	enet	11	0.12	7.6e-10	-5.13	5.8	8.8e-09	-0.02	0.95	0.05	FALSE
32	GTEx	Skin Sun Exposed Lower leg	AC004490.1	0.09	0.07	enet	11	0.10	2.3e-08	4.69	-5.5	4.4e-08	0.04	0.93	0.00	FALSE
37	GTEx	Testis	AC005786.7	0.36	0.19	enet	30	0.27	1.7e-12	-3.60	5.4	5.9e-08	-0.02	0.97	0.02	FALSE
7	GTEx	Artery Tibial	SGTA	0.11	0.04	enet	24	0.06	1.0e-05	6.43	-5.4	8.1e-08	0.00	0.44	0.53	FALSE
19	GTEx	Esophagus Muscularis	NFIC	0.21	0.03	enet	35	0.07	4.9e-05	-2.91	5.3	1.0e-07	0.04	0.09	0.13	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	HDGFRP2	0.03	0.02	lasso	3	0.02	1.2e-03	5.28	-5.3	1.3e-07	-0.08	0.25	0.30	FALSE
9	GTEx	Artery Tibial	SCAMP4	0.09	0.00	enet	18	0.01	5.8e-02	0.99	-5.3	1.4e-07	-0.12	0.06	0.17	FALSE
35	GTEx	Testis	MFSD12	0.23	0.11	enet	13	0.15	2.9e-07	-3.31	5.2	1.5e-07	-0.02	0.47	0.41	FALSE
47	YFS	Blood	SLC39A3	0.13	0.12	lasso	7	0.16	3.2e-48	4.00	5.2	1.5e-07	-0.04	1.00	0.00	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBXN6	0.05	0.01	blup	57	0.04	6.6e-05	0.71	-5.2	1.5e-07	0.02	0.03	0.92	FALSE
33	GTEx	Skin Sun Exposed Lower leg	AC004623.2	0.14	0.01	enet	14	0.00	2.5e-01	-3.27	-5.2	2.2e-07	0.06	0.04	0.08	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	BTBD2	0.04	0.02	blup	53	0.03	5.5e-04	-3.05	-5.2	2.3e-07	-0.06	0.37	0.02	FALSE