Hub : Genes

SCAMP4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0935	0.0368	0.0066	0.002	NA	0.009	NA	0.002	0.21000	NA	0.058	NA	0.210
2	GTEx	Brain Cerebellum	0.2910	0.0920	0.0010	0.130	NA	0.001	NA	0.047	0.00011	NA	0.290	NA	0.016
3	GTEx	Skin Sun Exposed Lower leg	0.1340	0.0470	0.0023	-0.001	NA	0.014	NA	0.002	0.41000	NA	0.023	NA	0.230
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0374	0.0220	0.0099	-0.002	0.008	0.005	NA	-0.002	0.73000	0.0410	0.082	NA	0.910
5	TCGA	Prostate Adenocarcinoma	0.0376	0.0203	0.0036	0.003	0.015	0.009	NA	0.011	0.14000	0.0095	0.037	NA	0.023

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	1.2	0.0	0.0	0.0	-0.4	1.1
Bipolar Disorder or Schizophrenia	0.7	1.6	5.1	0.0	0.0	0.0	1.7	2.3
Depressed Affect (Nagel 2018)	1.1	2.4	3.8	-0.7	1.7	1.9	-1.9	-1.1
Depression (Nagel 2018)	0.3	0.4	0.7	0.8	-0.5	0.8	-0.7	0.0
Intelligence (Savage-Jansen 2018)	2.6	8.1	20.4	0.9	-3.5	-0.2	2.7	4.5
Neuroticism (Nagel 2018)	0.6	1.3	3.4	-0.8	-0.1	1.9	-1.5	0.4
Schizophrenia (2018)	1.0	2.2	6.8	0.0	0.0	0.0	2.6	2.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.6	1.2	1.9	-0.9	-0.9	1.4	-1.2	1.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.6	0.5	-0.6	-0.1	0.4
Alzheimer’s Disease (in father)	0.5	0.6	1.8	0.5	-0.2	1.3	-0.7	0.5
Alzheimer’s Disease (including proxy)	0.3	0.5	1.1	1.0	0.2	0.4	-0.4	1.1
Crohns Disease (2017)	0.1	0.3	0.6	-0.4	-0.5	-0.8	-0.5	-0.5
Irritable Bowel Disease (IBD)	0.4	0.9	1.2	1.1	-0.8	-1.0	-1.1	-0.6
Ulcerative Colitis (UC)	0.4	0.7	1.5	1.2	-0.8	-0.8	-0.7	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.1	2.1	9.5	-3.1	0.0	-1.0	0.1	-0.4
Verbal and Numeric Reasoning (VNR)	1.6	3.8	11.0	1.1	-2.2	0.5	1.2	3.3
Breast Cancer	0.2	0.4	1.6	-1.3	-0.2	0.4	-0.6	0.2
Ovarian Cancer	1.5	2.0	4.1	-0.6	2.0	-1.0	-1.8	-1.2
Prostate Cancer	2.2	3.0	8.5	-0.6	-2.0	-2.9	-1.0	1.1
Age at First Birth	0.5	0.7	1.3	1.1	-0.8	0.2	0.0	1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	4.5	6.2	23.2	0.0	0.0	0.0	-2.8	-4.8
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.2	0.0	0.0	0.0	0.3	-0.4
Mean Putamen Volume	0.4	0.5	1.2	0.9	-0.5	-0.2	1.1	-0.1
Fasting Glucose	0.4	0.5	2.0	0.4	0.5	-1.4	0.0	0.2
HbA1C	1.3	1.4	5.1	-0.1	-0.2	0.2	2.2	1.4
HDL Cholesterol	0.5	0.8	2.8	0.0	0.0	0.0	1.1	1.7
LDL Cholesterol	0.0	0.0	0.1	0.0	0.0	0.0	-0.2	-0.0
Lupus	1.3	2.0	7.6	0.1	0.6	2.8	-1.4	0.4
Neuroticism (2016)	0.9	1.2	2.3	0.3	1.5	0.4	-1.2	-1.5
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.5	-0.0	0.3	0.1	0.5
Rheumatoid Arthritis	1.1	1.6	5.0	-0.6	2.2	0.0	-0.5	-1.5
Schizophrenia (2014)	1.1	2.5	7.7	0.0	0.0	0.0	2.8	2.2
Triglycerides	0.1	0.2	1.1	0.0	0.0	0.0	-0.2	-1.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.1	0.4	0.0	0.0	0.0	-0.0	0.7
Blood Eosinophil Count	0.3	2.2	9.7	-1.0	3.1	-0.2	-0.4	0.5
Blood Platelet Count	1.2	14.1	27.8	-5.3	1.5	-4.5	-1.4	-4.2
Blood Red Count	0.2	2.3	11.2	0.6	0.2	-3.4	0.2	0.2
Blood White Count	0.2	1.8	4.0	0.6	1.3	2.0	-1.1	1.3
Heel T-Score	0.1	0.6	1.6	-0.6	1.0	-1.3	-0.1	-0.4
BMI	2.4	14.2	33.5	-4.4	3.1	1.9	-2.1	-5.8
Height	0.1	2.4	9.5	3.1	0.9	0.8	-0.7	-0.6
Waist Hip Ratio (WHR)	0.3	1.3	3.0	-0.4	1.7	1.2	-0.8	-1.1
Systolic Blood Pressure	0.7	3.4	15.4	0.4	-0.7	3.9	0.4	0.7
Smoking Status	1.1	2.7	11.1	0.5	0.6	3.3	0.6	-1.2
Allergy or Eczema	0.2	0.6	2.3	0.1	-1.5	-0.5	-0.1	0.8
Cardiovascular Disease	2.0	6.6	21.9	-0.5	2.0	4.7	-2.0	-1.7
Hypothyroidism (self reported)	0.6	1.4	3.2	-1.1	1.5	0.4	1.8	0.6
Respiratory disease	0.3	0.6	1.6	-0.7	0.8	-0.4	-0.5	-1.3
Type 2 Diabetes (T2D) (2018)	1.5	2.7	5.8	-2.2	2.4	1.2	0.2	-1.1
Lung FEV1/FVC ratio	0.8	4.0	6.9	-2.3	-2.3	-2.6	-0.1	1.7
Lung FVC	0.6	3.0	11.2	3.3	-1.3	-1.3	0.5	0.3
Neuroticism	0.7	1.8	7.3	0.1	0.7	2.7	-0.9	0.2
Chronotype (morning person)	0.2	0.4	0.7	-0.7	-0.5	-0.8	0.8	0.4
Hair Pigment	0.1	3.9	9.2	-0.6	2.6	0.7	-3.0	-1.5
Tanning	0.1	0.7	3.0	0.7	-0.3	1.7	-0.0	0.2
Hand grip strength (left)	0.4	1.2	2.4	1.0	0.0	1.6	1.5	-0.2
Number of treatments/medications taken	1.5	2.7	5.2	1.2	1.5	2.3	-1.8	-1.1
Average weekly spirits intake	0.4	0.4	0.9	-0.4	0.8	0.2	-0.7	-0.9
Sensitivity / hurt feelings	0.9	1.6	3.1	-1.2	1.7	1.8	-0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.8	1.4	0.2	1.0	-0.2	0.3
Hearing difficulty/problems: Yes	0.5	0.8	1.6	1.2	0.8	-0.1	-0.5	-1.2
Relative age of first facial hair	1.6	3.3	7.0	2.7	-1.7	-0.2	1.5	2.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.7	0.6	0.8	0.7	-0.5	0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.5	-0.6	0.6	0.1	0.3
Ever had hysterectomy (womb removed)	0.7	0.8	3.1	1.8	0.9	-0.4	0.2	0.3
Systolic blood pressure, automated reading	0.7	2.0	8.4	-0.6	-1.1	2.9	0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	-0.8	-0.1	0.5	0.3	-0.9
Angina	1.6	2.1	7.3	-0.7	2.7	0.1	-0.8	-1.5
Medication for hormone replacement therapy	0.5	0.5	1.7	-0.5	-0.2	1.3	0.8	-0.3
Vitamin and mineral supplements	0.7	1.0	2.8	-0.2	-1.7	-0.9	0.4	1.0
Supplements: Zinc	0.3	0.4	0.9	0.9	0.8	0.3	0.0	-0.4
Medication: Co-codamol	1.2	1.4	3.5	0.5	1.4	0.4	-1.9	-1.0
Medication: Metformin	0.9	1.3	3.2	-1.4	1.8	-0.1	0.1	-1.2
Diabetes (father)	0.4	0.5	1.9	-1.4	-0.1	0.6	0.2	-0.1
Diabetes (mother)	2.1	2.7	4.0	-1.1	1.9	2.0	-1.0	-1.9
Severe depression (siblings)	3.0	3.4	7.8	-0.1	1.8	0.2	-2.8	-2.4
Pack years adult smoking proportion	0.6	0.8	1.5	-0.8	0.6	1.2	-0.5	-1.2
Impedance of leg (right)	1.7	8.5	18.1	4.0	-2.1	-1.5	1.3	4.3
Leg fat-free mass (left)	1.4	7.6	17.1	-2.3	3.0	2.2	-1.5	-4.1
Trunk fat percentage	1.7	6.7	11.3	-2.3	3.1	2.2	-1.5	-3.4
Hand grip strength (right)	0.6	1.5	3.2	0.9	0.5	1.8	1.8	-0.2
Townsend deprivation index at recruitment	1.2	1.7	4.7	0.6	0.8	2.2	-0.3	-1.6
Current tobacco smoking	2.8	4.6	13.9	0.4	2.3	3.7	-0.6	-1.8
Average weekly fortified wine intake	0.7	0.8	1.5	1.2	-0.8	0.1	0.6	1.1
Maternal smoking around birth	2.4	3.5	6.0	-1.5	2.0	2.4	-0.4	-2.4
Fed-up feelings	0.8	1.5	3.8	0.7	1.6	2.0	-0.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	3.0	1.7	-0.1	1.3	-0.2	-0.2
Relative age voice broke	0.6	0.9	3.8	1.9	-0.6	-0.1	-0.2	-0.5
Taking other prescription medications	1.5	2.4	6.0	2.4	-0.5	2.1	-0.9	0.7
Age when periods started (menarche)	0.9	2.3	7.7	-0.6	0.2	1.7	-0.4	-2.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	-0.8	0.4	0.3	0.5	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.5	0.9	0.5	1.2	-0.0	-0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	4.1	0.5	1.0	2.0	-0.5	-0.3
Qualifications: CSEs or equivalent	0.4	0.6	1.5	-0.9	-0.3	0.3	-0.7	-1.2
Serious illness, injury or assault to yourself	1.2	1.4	2.8	1.7	-0.7	0.7	0.7	1.7
High blood pressure	1.6	4.6	14.2	-1.2	0.5	3.8	-1.8	-1.9
Hayfever, allergic rhinitis or eczema	0.7	1.4	3.6	-0.4	-1.9	0.4	1.3	1.2
Multivitamins +/- minerals	0.5	0.6	1.9	-0.1	1.4	0.1	-0.1	-1.1
Stomach or abdominal pain in last month	0.6	0.7	2.0	-0.2	1.4	1.0	-0.4	-0.6
Supplements: Glucosamine	1.4	1.8	3.1	1.5	-0.9	0.1	1.7	1.8
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	3.0	1.6	0.0	1.7	-0.0	0.2
Medication: Atenolol	1.1	1.4	3.3	-0.8	0.3	1.6	-1.8	-0.6
Medication: Levothyroxine sodium	1.3	2.2	9.2	-0.8	3.0	0.6	0.7	-0.6
Sitting height	0.2	1.5	4.4	-0.1	2.1	1.8	0.2	-0.3
Chronic bronchitis/emphysema (father)	1.0	1.1	2.3	-1.0	-0.3	-1.3	-1.5	-0.8
High blood pressure (mother)	0.5	0.7	2.2	-1.0	0.2	1.5	-0.5	-0.1
Body mass index (BMI)	2.7	11.7	25.5	-3.9	2.9	2.7	-1.6	-5.1
Impedance of leg (left)	1.8	8.8	21.2	3.8	-2.1	-1.3	1.6	4.6
Leg predicted mass (left)	1.4	7.4	16.7	-2.2	2.9	2.2	-1.4	-4.1
Trunk fat mass	1.9	8.3	14.1	-2.3	3.5	2.7	-1.5	-3.8
Waist circumference	3.0	11.2	23.8	-2.8	3.5	2.7	-2.2	-4.9
Number of incorrect matches in round	1.0	1.6	3.0	1.6	-0.1	1.4	0.7	1.7
Past tobacco smoking	1.1	2.0	3.7	-1.6	1.9	-1.4	-1.2	-0.9
Alcohol usually taken with meals	1.0	1.7	3.8	1.4	-1.3	-0.8	-0.6	2.0
Nervous feelings	0.8	1.5	3.8	-1.4	-1.3	0.1	-0.3	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	0.9	-0.6	1.0	0.2	0.3
Hearing difficulty/problems with background noise	0.8	1.3	4.9	2.2	-0.8	-0.3	-0.8	0.3
Hair/balding pattern: Pattern 2	0.7	0.9	3.2	-0.0	-1.8	-0.7	0.8	-0.0
Had menopause	1.0	1.2	3.5	0.3	-0.3	-1.9	-1.1	-1.1
Had other major operations	0.7	0.9	2.8	1.7	0.7	0.2	-0.8	-0.6
Forced vital capacity (FVC)	0.4	1.6	5.2	2.3	-1.2	-1.0	0.6	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.7	0.0	0.9	0.3	0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	0.3	-0.3	1.1	0.8	0.2
Qualifications: None of the above	0.5	1.2	2.2	0.4	1.5	0.5	-1.3	-1.2
Financial difficulties in last 2 years	5.9	8.0	14.8	0.6	3.9	3.3	-2.2	-3.0
Mouth/teeth dental problems	1.8	2.8	5.2	-0.3	-2.1	-0.3	2.3	2.1
Heart attack	2.4	3.1	7.0	-1.3	2.1	-0.0	-1.5	-2.6
Allergy	0.8	1.7	4.0	0.3	2.0	-0.9	-1.5	-1.3
Pain all over the body in last month	1.9	2.0	5.5	-0.3	1.8	2.3	-0.7	-0.9
Diabetes (self-reported)	1.4	2.2	4.1	-2.0	2.0	1.5	0.3	-0.8
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.2	0.0	0.1	0.0	-0.4	0.1
Medication: Ramipril	1.1	1.4	2.5	-1.0	1.1	1.5	-0.3	-1.6
Medication: Simvastatin	0.9	1.3	3.5	0.4	0.2	1.4	-0.9	-1.9
Fluid intelligence score	0.8	1.6	6.0	0.9	-1.0	0.1	0.3	2.4
Illnesses of siblings	0.2	0.2	0.6	-0.6	-0.2	0.8	-0.2	0.3
Neuroticism score	0.6	1.3	5.2	0.0	0.5	2.3	-0.5	0.8
Weight	1.9	9.3	19.4	-2.4	3.3	2.8	-1.7	-4.4
Impedance of arm (right)	0.6	2.8	7.3	2.2	-0.7	-1.0	-0.2	2.7
Arm fat percentage (right)	2.2	8.7	14.4	-2.9	2.9	3.1	-1.5	-3.8
Trunk fat-free mass	0.5	2.8	6.7	-0.6	1.9	1.7	-0.8	-2.6
Hip circumference	2.1	9.2	18.7	-2.6	2.9	2.7	-2.1	-4.3
Time employed in main current job	0.6	0.7	1.0	-0.4	-0.8	-0.9	1.0	0.9
Alcohol intake versus 10 years previously	0.3	0.5	1.5	-0.4	0.5	1.2	-0.6	0.2
Father’s age at death	0.7	0.9	2.2	1.5	-0.2	-1.3	-0.6	0.5
Worrier / anxious feelings	0.4	0.7	1.8	-0.2	-0.3	-0.6	-1.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	6.0	-0.8	2.4	0.7	-1.3	-2.1
Falls in the last year	0.8	1.1	2.8	-0.8	-0.2	-0.6	-1.7	-1.1
Hair/balding pattern: Pattern 3	0.6	0.8	3.3	1.8	0.1	0.8	-0.5	0.2
Number of live births	3.2	4.5	11.2	-0.5	1.9	-0.9	-2.5	-3.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.4	1.6	-1.0	-1.2	-0.2	0.3
Pulse rate	0.3	0.6	1.1	-1.1	0.4	-0.9	-0.8	0.3
Happiness	0.8	1.0	2.6	1.6	-0.1	0.9	0.8	0.9
Noisy workplace	1.0	1.2	3.2	-0.2	1.8	0.6	0.1	-1.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.5	0.5	-1.9	-1.0	0.7	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.0	1.3	-0.2	1.7	-0.5	-1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	1.2	0.8	0.5	0.3	-0.1
Asthma	0.1	0.2	1.1	-0.0	0.2	-0.2	1.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.6	-0.1	1.2	-0.4	-0.5	-1.2
Medication: Cholesterol lowering	1.1	1.7	6.6	0.6	0.7	2.6	-0.5	-0.8
Depression (self-reported)	0.8	1.0	1.8	1.0	0.0	1.3	-1.2	0.8
Medication: Lansoprazole	3.4	3.9	10.7	-1.9	0.8	-0.8	-3.3	-2.0
Prospective memory result	0.9	1.1	4.1	-2.0	0.9	0.6	-0.1	-0.5
Lung cancer (father)	1.8	2.1	3.5	-1.9	0.8	0.3	-1.7	-1.8
Illnesses of mother	0.6	0.7	1.9	1.4	-0.6	-1.1	0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.1	0.7	-1.2	-1.4	-0.6	0.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	-0.9	0.2	-0.5	0.4	0.4
Impedance of arm (left)	0.5	2.1	4.0	1.9	-0.6	-1.3	-0.8	2.0
Arm fat mass (right)	2.3	9.6	17.6	-2.7	3.1	3.3	-1.5	-4.2
Trunk predicted mass	0.5	2.8	6.4	-0.6	1.8	1.8	-0.7	-2.5
Standing height	0.3	2.6	9.8	3.1	1.1	1.1	-0.4	0.9
Length of working week for main job	0.5	0.5	1.7	-1.3	0.5	0.0	0.7	-0.5
Exposure to tobacco smoke at home	0.7	0.8	1.8	-0.7	1.2	-0.1	-0.6	-1.4
Breastfed as a baby	0.5	0.6	1.8	-0.6	-0.4	-0.4	-1.3	-0.7
Tense / ‘highly strung’	0.7	1.1	4.3	-0.2	-2.1	0.8	-0.1	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	0.4	0.6	0.1	-0.9	-1.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	-0.8	0.0	1.0	0.1	-1.0
Birth weight of first child	1.6	2.9	9.1	-3.0	0.5	-1.8	1.1	-0.8
Peak expiratory flow (PEF)	0.6	1.5	4.7	2.2	-1.1	-0.1	0.0	1.2
Pulse wave reflection index	0.6	0.7	2.3	0.7	0.8	1.5	-0.1	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.6	0.8	0.3	0.2	-0.0
Loud music exposure frequency	1.2	1.4	4.7	-1.0	0.7	-0.6	-0.2	-2.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.7	-1.6	-0.8	-0.0	0.0	0.0
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	5.5	0.9	1.7	-0.6	-2.3	-1.7
Blood clot in the leg (DVT)	0.5	0.6	2.1	0.6	1.4	0.7	0.0	0.2
Medication: Paracetamol	1.6	2.6	5.3	-1.0	2.3	0.4	-1.4	-2.2
Headache pain in last month	0.9	1.5	3.8	-0.6	0.7	-1.2	-1.9	-1.2
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	6.2	-1.0	-1.2	-2.5	1.9	1.2
Glaucoma (self-reported)	0.9	1.0	2.3	0.3	-1.5	-0.8	0.3	1.5
Gout (self-reported)	0.9	1.2	3.1	-1.8	-1.1	1.0	-0.5	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.7	0.2	0.7	0.5	1.6	0.9
Medication: Amlodipine	0.9	1.3	4.4	0.1	1.0	0.7	-0.8	-2.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	1.1	1.4	0.7	-0.1	-0.2
Birth weight	1.0	2.1	6.2	-1.7	0.4	-2.5	1.1	-0.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.5	0.6	0.8	1.2	0.1	-1.1
High blood pressure (siblings)	0.3	0.4	1.1	1.1	-0.2	-0.4	0.7	-0.4
Forced vital capacity (FVC), Best measure	0.3	1.0	1.9	1.4	-1.2	-1.1	0.2	0.7
Body fat percentage	1.9	7.3	13.3	-2.4	3.1	2.4	-1.5	-3.6
Leg fat percentage (right)	1.4	5.0	9.8	-1.8	2.4	2.2	-1.0	-3.1
Arm fat-free mass (right)	0.7	3.4	8.7	-1.1	1.9	1.7	-0.5	-3.0
Exposure to tobacco smoke outside home	0.6	0.8	1.7	-1.3	1.2	0.5	0.6	-0.7
Comparative body size at age 10	0.5	1.3	5.2	-2.3	0.0	-0.8	0.0	-0.7
Number of full brothers	1.1	1.3	3.6	-1.4	-0.4	-1.9	0.7	-0.7
Worry too long after embarrassment	2.7	4.5	8.2	2.2	-2.2	1.3	1.7	2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.0	1.4	-0.1	1.0	-1.4	-0.0
Wheeze or whistling in the chest in last year	4.6	8.3	14.4	-1.9	3.5	2.0	-2.7	-3.8
Number of children fathered	0.4	0.5	2.2	-0.2	-0.4	1.5	0.2	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	5.3	-0.5	-2.3	-0.8	-1.0	0.6
Age at first live birth	1.0	1.8	4.4	2.1	-0.9	-0.1	0.3	1.9
Pulse wave peak to peak time	0.4	0.4	1.3	1.1	-0.3	0.7	-0.5	-0.3
Health satisfaction	1.7	2.2	3.2	0.6	1.1	1.8	-1.7	-1.8
Shortness of breath walking on level ground	3.3	4.0	11.2	-1.2	1.9	1.4	-1.2	-3.4
Qualifications: College or University degree	1.6	4.9	9.0	2.4	-3.0	-1.5	0.1	2.7
Eye problems/disorders: None of the above	0.7	0.8	3.5	1.9	0.5	0.0	-0.0	-0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	0.4	-0.8	-0.4	0.7	0.2
Emphysema/chronic bronchitis	0.7	0.8	1.3	-0.6	1.1	0.9	1.1	-0.6
Medication for pain relief, constipation, heartburn	2.2	3.8	9.0	0.1	-1.2	-1.7	3.0	2.4
Neck or shoulder pain in last month	0.6	0.8	1.4	-0.2	1.2	-0.2	-1.1	-1.1
Medication: Blood pressure	1.7	3.0	8.4	-0.0	1.8	2.9	-1.5	-1.1
Angina (self-reported)	1.7	2.2	6.9	-0.9	2.6	0.3	-1.0	-1.5
Migraine (self-reported)	0.4	0.5	1.8	-0.6	0.2	0.6	-1.3	0.1
Medication: Ibuprofen	1.1	1.3	3.2	0.4	1.8	-0.2	-1.1	-1.4
Medication: Allopurinol	0.6	0.8	2.4	-1.6	-0.8	0.7	-0.5	0.5
Medication: Omeprazole	0.5	0.6	1.7	1.3	-0.2	0.8	-0.6	0.8
Medication: Seretide 50 evohaler	1.8	2.0	6.4	2.5	-0.8	1.0	1.4	0.4
Mean time to correctly identify matches	0.8	1.6	4.3	-2.1	0.0	-1.7	-0.1	-0.7
Heart disease (mother)	0.3	0.4	1.1	-1.0	-0.4	-0.0	0.7	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.6	0.2	1.4	1.9	-0.8	-0.3
Whole body fat mass	1.9	7.9	14.7	-2.2	3.2	2.8	-1.3	-3.8
Leg fat mass (right)	1.8	7.0	12.9	-1.8	2.8	3.0	-1.3	-3.6
Arm predicted mass (right)	0.8	4.2	10.3	-1.5	2.5	1.5	-0.6	-3.2
Pulse rate, automated reading	0.2	0.7	1.2	-0.0	1.0	0.7	-1.0	1.1
Alcohol intake frequency.	1.1	2.5	8.6	0.5	1.8	2.9	0.5	0.1
Comparative height size at age 10	0.3	1.5	5.6	2.4	0.8	0.6	-1.0	-0.2
Number of full sisters	2.0	2.4	5.5	-0.4	1.2	2.3	-1.4	-1.7
Suffer from ‘nerves’	0.3	0.5	1.0	-0.7	-0.0	1.0	-0.8	-0.4
Overall health rating	2.7	5.9	13.3	-0.5	3.2	3.6	-1.3	-2.0
Chest pain or discomfort	0.2	0.3	1.0	0.5	1.0	0.4	0.5	-0.1
Had major operations	1.1	1.3	3.4	1.1	-1.2	-0.1	-0.8	1.9
Age at last live birth	0.9	1.3	4.4	2.1	-0.2	0.5	-0.6	1.2
Family relationship satisfaction	0.3	0.3	0.9	0.2	0.3	1.0	0.1	-0.7
Leg pain on walking	1.8	2.3	5.4	-1.3	1.6	1.3	-0.4	-2.3
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	5.9	-1.4	1.3	-0.5	-0.4	-2.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.6	-1.2	1.2	0.2	-0.9	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.9	-1.7	-0.0	-1.2	-0.1	0.7
Medication: Aspirin	1.2	1.6	2.3	1.5	0.1	1.5	-1.5	-1.1
Supplements: Vitamin C	1.5	1.7	2.6	1.1	1.5	0.7	-1.5	-1.6
Knee pain experienced in last month	0.1	0.1	0.2	0.4	-0.1	0.3	0.3	-0.5
Hypertension (Self-reported)	2.0	5.7	13.9	-1.6	1.0	3.7	-2.2	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.8	-0.6	-0.2	0.4	-1.4	0.6
Illnesses of father: Heart disease	0.9	1.3	3.0	1.0	1.7	1.3	-0.5	-0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.5	-1.2	-0.1	-0.3	-0.2	-1.0
Smoking status: Previous	1.2	1.9	5.5	0.9	-2.4	0.2	1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.4	1.2	-0.1	-0.0	-0.1	0.1
Whole body fat-free mass	0.8	4.5	10.3	-1.4	2.4	1.9	-0.9	-3.2
Leg fat-free mass (right)	1.3	7.2	15.3	-2.4	2.9	2.2	-1.3	-3.9
Arm fat percentage (left)	2.5	9.8	18.2	-3.0	3.0	3.0	-1.9	-4.3
Average weekly red wine intake	1.0	1.4	3.1	-1.8	-1.4	-1.1	-0.8	0.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.0	-1.0	-0.7	1.4	1.0	1.2
Mood swings	1.7	3.0	5.0	-0.8	2.0	1.6	-2.2	-1.8
Loneliness, isolation	2.2	3.1	7.6	0.5	2.8	1.6	-1.1	-1.9
Long-standing illness, disability or infirmity	1.7	2.6	7.0	0.1	2.6	2.0	-1.2	-0.9
Ever had bowel cancer screening	1.5	1.7	5.3	0.4	0.5	-2.3	-1.6	-0.4
Diabetes diagnosed by doctor	1.3	2.1	5.2	-1.6	2.3	1.5	-0.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.7	0.3	-0.2	-0.5	-0.5
Friendships satisfaction	0.5	0.7	1.7	0.4	0.3	-1.2	-1.3	-0.1
Qualifications: nursing, teaching	0.8	1.2	2.8	1.7	-1.0	-0.0	0.7	1.4
Commuting to job workplace: Walk	3.7	3.9	12.0	3.5	-2.6	0.2	-0.2	0.8
Eye problems/disorders: Cataract	1.7	2.0	9.4	-3.1	0.2	-0.8	-0.0	0.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	5.4	-0.6	0.7	-1.4	-1.8	-2.3
Medication for cholesterol	1.3	2.0	4.2	0.9	-0.8	-2.0	0.5	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.0	1.2	0.7	-0.4	-0.9	-1.4
Back pain experienced in last month	2.9	4.3	7.1	-1.4	2.7	1.4	-2.1	-2.5
Mineral and other dietary supplements	0.8	1.1	3.8	-1.9	0.1	-0.1	-0.1	-1.3
Breast cancer (self-reported)	0.5	0.6	1.9	1.4	-0.4	-0.3	-0.0	1.0
Asthma (self-reported)	0.1	0.2	1.1	0.2	0.2	-0.2	1.0	-0.0
Osteoporosis (self-reported)	0.4	0.4	1.5	0.8	0.2	-0.2	0.4	1.2
Osteoarthritis (self-reported)	0.6	0.8	3.0	-0.5	0.2	1.7	-0.6	-0.6
Medication: Aspirin	1.2	1.6	2.6	1.2	0.0	1.6	-1.5	-1.3
Medication: Gliclazide	0.5	0.5	1.1	-0.5	0.8	0.0	-0.8	-1.1
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	-0.8	-0.6	-0.5	0.2	0.7
Smoking status: Current	2.7	4.3	13.2	0.3	2.0	3.6	-0.7	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.3	-0.2	-0.4	-2.1	-1.0	0.2
Whole body water mass	0.8	4.5	9.9	-1.5	2.4	2.0	-0.8	-3.1
Leg predicted mass (right)	1.3	7.1	15.4	-2.4	2.9	2.1	-1.4	-3.9
Arm fat mass (left)	2.3	9.4	18.3	-2.5	3.1	3.3	-1.5	-4.3
Number of self-reported non-cancer illnesses	1.6	2.8	6.7	1.1	1.5	2.6	-1.9	-0.4
Average weekly champagne plus white wine intake	0.3	0.4	1.5	0.3	0.0	-1.2	-0.6	-0.4
Miserableness	0.7	1.2	4.5	0.3	0.9	2.1	-0.5	0.4
Guilty feelings	0.4	0.6	2.0	0.2	-0.7	1.4	-0.2	0.7
Wears glasses or contact lenses	0.4	0.5	1.8	-0.2	-0.2	-1.4	-0.5	0.3
Ever taken oral contraceptive pill	0.9	1.0	3.1	0.4	-0.3	-1.8	-0.9	-0.9
Hearing aid user	2.1	2.3	6.9	-2.6	0.3	-1.9	0.8	0.5
Mother’s age at death	0.8	1.0	2.0	1.0	-1.0	-0.5	0.9	1.4
Financial situation satisfaction	0.6	0.8	1.8	0.0	1.4	1.3	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.5	1.0	-0.6	-0.2	1.6	0.6
Commuting to job workplace: Public transport	0.4	0.4	0.7	-0.6	0.8	-0.2	0.6	0.9
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	0.7	-0.8	0.4	-0.1	1.0
Medication: Blood pressure	1.5	2.8	9.8	-0.8	0.6	3.1	-1.0	-1.5
Pain type(s) experienced in last month: Hip pain	3.1	3.9	5.9	-0.8	2.1	1.6	-2.4	-2.4
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.7	0.9	0.6	-0.0	-1.9	-0.2
High cholesterol (Self-reported)	2.2	3.8	5.6	0.7	2.4	1.7	-2.2	-2.3
Medication: Bendroflumethiazide	0.7	1.1	2.8	-0.2	-0.1	1.6	-1.7	-0.0
Medication: Paracetamol	1.7	2.7	5.8	-0.9	2.4	0.9	-1.3	-2.0
Medication: Lisinopril	0.3	0.4	1.4	0.0	0.3	1.2	-0.3	-0.6
Medication: Atorvastatin	2.5	3.1	6.7	-0.9	2.6	1.0	-1.6	-2.1
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.4	-0.5	-0.1	0.1	0.3
Alcohol drinker status: Never	1.2	1.5	3.1	-1.7	1.8	0.9	0.6	-0.1
Ever smoked	0.8	1.4	3.4	1.0	-1.9	1.3	0.8	0.5
Basal metabolic rate	1.1	6.0	12.9	-1.7	2.7	2.4	-1.1	-3.6
Leg fat percentage (left)	1.6	5.7	10.4	-2.2	2.7	2.3	-1.0	-3.2
Arm fat-free mass (left)	0.8	4.0	8.5	-1.3	2.4	1.9	-0.6	-2.9
Number of operations (self-reported)	0.3	0.4	0.9	0.6	-0.1	0.5	-1.0	0.5
Average weekly beer plus cider intake	0.6	0.8	1.9	0.1	1.4	1.0	0.4	-1.1
Irritability	1.0	1.7	2.7	1.6	0.2	1.6	-1.2	1.3
Risk taking	1.1	1.7	4.9	-1.6	0.9	-0.3	-0.3	-2.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	0.4	-0.4	-1.0	-0.4	0.5
Fractured/broken bones in last 5 years	1.0	1.3	4.6	-0.2	0.6	-0.9	-2.2	-0.8
Age started oral contraceptive pill	1.6	2.0	8.3	-0.1	-1.2	-2.9	0.3	0.5
Diastolic blood pressure, automated reading	0.3	1.1	4.1	1.0	0.3	2.0	-0.4	-0.3
Ever depressed for a whole week	3.1	3.9	6.6	2.1	-2.6	0.3	1.7	2.3
Unable to work because of sickness or disability	2.9	3.7	7.9	0.6	2.6	0.9	-2.8	-1.8
Commuting to job workplace: Cycle	0.4	0.5	1.9	1.4	0.6	-0.3	-0.1	0.5
Myopia	0.1	0.1	0.5	0.3	0.1	-0.1	0.7	-0.0
Vascular/heart problems diagnosed by doctor	1.9	5.3	13.4	1.4	-1.2	-3.7	2.0	2.4
Cholesterol lowering medication	1.8	2.6	7.4	0.2	1.8	0.9	-1.2	-2.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	0.5	-0.0	1.1	-0.9	0.4
Pain experienced in last month	1.2	2.1	3.5	0.6	-1.5	-0.9	1.9	1.9
Supplements: Calcium	0.7	0.7	1.4	1.2	-0.1	-0.5	1.1	1.0
Basal cell carcinoma (self-reported)	1.4	1.7	4.3	-0.9	1.0	-2.1	0.4	-1.5
Heart attack/myocardial infarction (self-reported)	2.4	3.1	7.4	-1.4	1.9	-0.1	-1.7	-2.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.3	0.8	1.5	0.6	0.1	0.3
Heart disease (siblings)	0.6	0.8	1.8	0.2	1.0	-0.2	-1.3	-1.0
Alcohol drinker status: Previous	1.2	1.3	4.3	0.8	0.6	1.0	-2.1	-0.7
Pack years of smoking	0.6	0.9	2.0	-1.0	0.8	0.6	-0.7	-1.4
Impedance of whole body	1.1	5.6	13.8	3.1	-1.5	-1.4	0.6	3.7
Leg fat mass (left)	1.9	7.3	13.3	-1.9	2.9	3.1	-1.2	-3.6
Arm predicted mass (left)	0.7	3.7	6.9	-1.1	2.2	2.2	-0.4	-2.6