Hub : Genes

SCAMP4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0935 0.0368 0.0066 0.002 NA 0.009 NA 0.002 0.21000 NA 0.058 NA 0.210
2 GTEx Brain Cerebellum 0.2910 0.0920 0.0010 0.130 NA 0.001 NA 0.047 0.00011 NA 0.290 NA 0.016
3 GTEx Skin Sun Exposed Lower leg 0.1340 0.0470 0.0023 -0.001 NA 0.014 NA 0.002 0.41000 NA 0.023 NA 0.230
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0374 0.0220 0.0099 -0.002 0.008 0.005 NA -0.002 0.73000 0.0410 0.082 NA 0.910
5 TCGA Prostate Adenocarcinoma 0.0376 0.0203 0.0036 0.003 0.015 0.009 NA 0.011 0.14000 0.0095 0.037 NA 0.023

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 1.2 0.0 0.0 0.0 -0.4 1.1
Bipolar Disorder or Schizophrenia 0.7 1.6 5.1 0.0 0.0 0.0 1.7 2.3
Depressed Affect (Nagel 2018) 1.1 2.4 3.8 -0.7 1.7 1.9 -1.9 -1.1
Depression (Nagel 2018) 0.3 0.4 0.7 0.8 -0.5 0.8 -0.7 0.0
Intelligence (Savage-Jansen 2018) 2.6 8.1 20.4 0.9 -3.5 -0.2 2.7 4.5
Neuroticism (Nagel 2018) 0.6 1.3 3.4 -0.8 -0.1 1.9 -1.5 0.4
Schizophrenia (2018) 1.0 2.2 6.8 0.0 0.0 0.0 2.6 2.0
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.6 1.2 1.9 -0.9 -0.9 1.4 -1.2 1.1
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 0.6 0.5 -0.6 -0.1 0.4
Alzheimer’s Disease (in father) 0.5 0.6 1.8 0.5 -0.2 1.3 -0.7 0.5
Alzheimer’s Disease (including proxy) 0.3 0.5 1.1 1.0 0.2 0.4 -0.4 1.1
Crohns Disease (2017) 0.1 0.3 0.6 -0.4 -0.5 -0.8 -0.5 -0.5
Irritable Bowel Disease (IBD) 0.4 0.9 1.2 1.1 -0.8 -1.0 -1.1 -0.6
Ulcerative Colitis (UC) 0.4 0.7 1.5 1.2 -0.8 -0.8 -0.7 -0.2
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.1 2.1 9.5 -3.1 0.0 -1.0 0.1 -0.4
Verbal and Numeric Reasoning (VNR) 1.6 3.8 11.0 1.1 -2.2 0.5 1.2 3.3
Breast Cancer 0.2 0.4 1.6 -1.3 -0.2 0.4 -0.6 0.2
Ovarian Cancer 1.5 2.0 4.1 -0.6 2.0 -1.0 -1.8 -1.2
Prostate Cancer 2.2 3.0 8.5 -0.6 -2.0 -2.9 -1.0 1.1
Age at First Birth 0.5 0.7 1.3 1.1 -0.8 0.2 0.0 1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 4.5 6.2 23.2 0.0 0.0 0.0 -2.8 -4.8
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.0 0.1 0.2 0.0 0.0 0.0 0.3 -0.4
Mean Putamen Volume 0.4 0.5 1.2 0.9 -0.5 -0.2 1.1 -0.1
Fasting Glucose 0.4 0.5 2.0 0.4 0.5 -1.4 0.0 0.2
HbA1C 1.3 1.4 5.1 -0.1 -0.2 0.2 2.2 1.4
HDL Cholesterol 0.5 0.8 2.8 0.0 0.0 0.0 1.1 1.7
LDL Cholesterol 0.0 0.0 0.1 0.0 0.0 0.0 -0.2 -0.0
Lupus 1.3 2.0 7.6 0.1 0.6 2.8 -1.4 0.4
Neuroticism (2016) 0.9 1.2 2.3 0.3 1.5 0.4 -1.2 -1.5
Primary Biliary Cirrhosis 0.1 0.1 0.2 0.5 -0.0 0.3 0.1 0.5
Rheumatoid Arthritis 1.1 1.6 5.0 -0.6 2.2 0.0 -0.5 -1.5
Schizophrenia (2014) 1.1 2.5 7.7 0.0 0.0 0.0 2.8 2.2
Triglycerides 0.1 0.2 1.1 0.0 0.0 0.0 -0.2 -1.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.1 0.1 0.4 0.0 0.0 0.0 -0.0 0.7
Blood Eosinophil Count 0.3 2.2 9.7 -1.0 3.1 -0.2 -0.4 0.5
Blood Platelet Count 1.2 14.1 27.8 -5.3 1.5 -4.5 -1.4 -4.2
Blood Red Count 0.2 2.3 11.2 0.6 0.2 -3.4 0.2 0.2
Blood White Count 0.2 1.8 4.0 0.6 1.3 2.0 -1.1 1.3
Heel T-Score 0.1 0.6 1.6 -0.6 1.0 -1.3 -0.1 -0.4
BMI 2.4 14.2 33.5 -4.4 3.1 1.9 -2.1 -5.8
Height 0.1 2.4 9.5 3.1 0.9 0.8 -0.7 -0.6
Waist Hip Ratio (WHR) 0.3 1.3 3.0 -0.4 1.7 1.2 -0.8 -1.1
Systolic Blood Pressure 0.7 3.4 15.4 0.4 -0.7 3.9 0.4 0.7
Smoking Status 1.1 2.7 11.1 0.5 0.6 3.3 0.6 -1.2
Allergy or Eczema 0.2 0.6 2.3 0.1 -1.5 -0.5 -0.1 0.8
Cardiovascular Disease 2.0 6.6 21.9 -0.5 2.0 4.7 -2.0 -1.7
Hypothyroidism (self reported) 0.6 1.4 3.2 -1.1 1.5 0.4 1.8 0.6
Respiratory disease 0.3 0.6 1.6 -0.7 0.8 -0.4 -0.5 -1.3
Type 2 Diabetes (T2D) (2018) 1.5 2.7 5.8 -2.2 2.4 1.2 0.2 -1.1
Lung FEV1/FVC ratio 0.8 4.0 6.9 -2.3 -2.3 -2.6 -0.1 1.7
Lung FVC 0.6 3.0 11.2 3.3 -1.3 -1.3 0.5 0.3
Neuroticism 0.7 1.8 7.3 0.1 0.7 2.7 -0.9 0.2
Chronotype (morning person) 0.2 0.4 0.7 -0.7 -0.5 -0.8 0.8 0.4
Hair Pigment 0.1 3.9 9.2 -0.6 2.6 0.7 -3.0 -1.5
Tanning 0.1 0.7 3.0 0.7 -0.3 1.7 -0.0 0.2
Hand grip strength (left) 0.4 1.2 2.4 1.0 0.0 1.6 1.5 -0.2
Number of treatments/medications taken 1.5 2.7 5.2 1.2 1.5 2.3 -1.8 -1.1
Average weekly spirits intake 0.4 0.4 0.9 -0.4 0.8 0.2 -0.7 -0.9
Sensitivity / hurt feelings 0.9 1.6 3.1 -1.2 1.7 1.8 -0.6 -0.4
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.8 1.4 0.2 1.0 -0.2 0.3
Hearing difficulty/problems: Yes 0.5 0.8 1.6 1.2 0.8 -0.1 -0.5 -1.2
Relative age of first facial hair 1.6 3.3 7.0 2.7 -1.7 -0.2 1.5 2.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.7 0.6 0.8 0.7 -0.5 0.8
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 0.5 -0.6 0.6 0.1 0.3
Ever had hysterectomy (womb removed) 0.7 0.8 3.1 1.8 0.9 -0.4 0.2 0.3
Systolic blood pressure, automated reading 0.7 2.0 8.4 -0.6 -1.1 2.9 0.2 -0.3
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.8 -0.8 -0.1 0.5 0.3 -0.9
Angina 1.6 2.1 7.3 -0.7 2.7 0.1 -0.8 -1.5
Medication for hormone replacement therapy 0.5 0.5 1.7 -0.5 -0.2 1.3 0.8 -0.3
Vitamin and mineral supplements 0.7 1.0 2.8 -0.2 -1.7 -0.9 0.4 1.0
Supplements: Zinc 0.3 0.4 0.9 0.9 0.8 0.3 0.0 -0.4
Medication: Co-codamol 1.2 1.4 3.5 0.5 1.4 0.4 -1.9 -1.0
Medication: Metformin 0.9 1.3 3.2 -1.4 1.8 -0.1 0.1 -1.2
Diabetes (father) 0.4 0.5 1.9 -1.4 -0.1 0.6 0.2 -0.1
Diabetes (mother) 2.1 2.7 4.0 -1.1 1.9 2.0 -1.0 -1.9
Severe depression (siblings) 3.0 3.4 7.8 -0.1 1.8 0.2 -2.8 -2.4
Pack years adult smoking proportion 0.6 0.8 1.5 -0.8 0.6 1.2 -0.5 -1.2
Impedance of leg (right) 1.7 8.5 18.1 4.0 -2.1 -1.5 1.3 4.3
Leg fat-free mass (left) 1.4 7.6 17.1 -2.3 3.0 2.2 -1.5 -4.1
Trunk fat percentage 1.7 6.7 11.3 -2.3 3.1 2.2 -1.5 -3.4
Hand grip strength (right) 0.6 1.5 3.2 0.9 0.5 1.8 1.8 -0.2
Townsend deprivation index at recruitment 1.2 1.7 4.7 0.6 0.8 2.2 -0.3 -1.6
Current tobacco smoking 2.8 4.6 13.9 0.4 2.3 3.7 -0.6 -1.8
Average weekly fortified wine intake 0.7 0.8 1.5 1.2 -0.8 0.1 0.6 1.1
Maternal smoking around birth 2.4 3.5 6.0 -1.5 2.0 2.4 -0.4 -2.4
Fed-up feelings 0.8 1.5 3.8 0.7 1.6 2.0 -0.6 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 3.0 1.7 -0.1 1.3 -0.2 -0.2
Relative age voice broke 0.6 0.9 3.8 1.9 -0.6 -0.1 -0.2 -0.5
Taking other prescription medications 1.5 2.4 6.0 2.4 -0.5 2.1 -0.9 0.7
Age when periods started (menarche) 0.9 2.3 7.7 -0.6 0.2 1.7 -0.4 -2.8
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.3 -0.8 0.4 0.3 0.5 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.5 0.9 0.5 1.2 -0.0 -0.3
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 4.1 0.5 1.0 2.0 -0.5 -0.3
Qualifications: CSEs or equivalent 0.4 0.6 1.5 -0.9 -0.3 0.3 -0.7 -1.2
Serious illness, injury or assault to yourself 1.2 1.4 2.8 1.7 -0.7 0.7 0.7 1.7
High blood pressure 1.6 4.6 14.2 -1.2 0.5 3.8 -1.8 -1.9
Hayfever, allergic rhinitis or eczema 0.7 1.4 3.6 -0.4 -1.9 0.4 1.3 1.2
Multivitamins +/- minerals 0.5 0.6 1.9 -0.1 1.4 0.1 -0.1 -1.1
Stomach or abdominal pain in last month 0.6 0.7 2.0 -0.2 1.4 1.0 -0.4 -0.6
Supplements: Glucosamine 1.4 1.8 3.1 1.5 -0.9 0.1 1.7 1.8
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 3.0 1.6 0.0 1.7 -0.0 0.2
Medication: Atenolol 1.1 1.4 3.3 -0.8 0.3 1.6 -1.8 -0.6
Medication: Levothyroxine sodium 1.3 2.2 9.2 -0.8 3.0 0.6 0.7 -0.6
Sitting height 0.2 1.5 4.4 -0.1 2.1 1.8 0.2 -0.3
Chronic bronchitis/emphysema (father) 1.0 1.1 2.3 -1.0 -0.3 -1.3 -1.5 -0.8
High blood pressure (mother) 0.5 0.7 2.2 -1.0 0.2 1.5 -0.5 -0.1
Body mass index (BMI) 2.7 11.7 25.5 -3.9 2.9 2.7 -1.6 -5.1
Impedance of leg (left) 1.8 8.8 21.2 3.8 -2.1 -1.3 1.6 4.6
Leg predicted mass (left) 1.4 7.4 16.7 -2.2 2.9 2.2 -1.4 -4.1
Trunk fat mass 1.9 8.3 14.1 -2.3 3.5 2.7 -1.5 -3.8
Waist circumference 3.0 11.2 23.8 -2.8 3.5 2.7 -2.2 -4.9
Number of incorrect matches in round 1.0 1.6 3.0 1.6 -0.1 1.4 0.7 1.7
Past tobacco smoking 1.1 2.0 3.7 -1.6 1.9 -1.4 -1.2 -0.9
Alcohol usually taken with meals 1.0 1.7 3.8 1.4 -1.3 -0.8 -0.6 2.0
Nervous feelings 0.8 1.5 3.8 -1.4 -1.3 0.1 -0.3 2.0
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.0 0.9 -0.6 1.0 0.2 0.3
Hearing difficulty/problems with background noise 0.8 1.3 4.9 2.2 -0.8 -0.3 -0.8 0.3
Hair/balding pattern: Pattern 2 0.7 0.9 3.2 -0.0 -1.8 -0.7 0.8 -0.0
Had menopause 1.0 1.2 3.5 0.3 -0.3 -1.9 -1.1 -1.1
Had other major operations 0.7 0.9 2.8 1.7 0.7 0.2 -0.8 -0.6
Forced vital capacity (FVC) 0.4 1.6 5.2 2.3 -1.2 -1.0 0.6 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 0.7 0.0 0.9 0.3 0.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.3 0.3 -0.3 1.1 0.8 0.2
Qualifications: None of the above 0.5 1.2 2.2 0.4 1.5 0.5 -1.3 -1.2
Financial difficulties in last 2 years 5.9 8.0 14.8 0.6 3.9 3.3 -2.2 -3.0
Mouth/teeth dental problems 1.8 2.8 5.2 -0.3 -2.1 -0.3 2.3 2.1
Heart attack 2.4 3.1 7.0 -1.3 2.1 -0.0 -1.5 -2.6
Allergy 0.8 1.7 4.0 0.3 2.0 -0.9 -1.5 -1.3
Pain all over the body in last month 1.9 2.0 5.5 -0.3 1.8 2.3 -0.7 -0.9
Diabetes (self-reported) 1.4 2.2 4.1 -2.0 2.0 1.5 0.3 -0.8
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.2 0.0 0.1 0.0 -0.4 0.1
Medication: Ramipril 1.1 1.4 2.5 -1.0 1.1 1.5 -0.3 -1.6
Medication: Simvastatin 0.9 1.3 3.5 0.4 0.2 1.4 -0.9 -1.9
Fluid intelligence score 0.8 1.6 6.0 0.9 -1.0 0.1 0.3 2.4
Illnesses of siblings 0.2 0.2 0.6 -0.6 -0.2 0.8 -0.2 0.3
Neuroticism score 0.6 1.3 5.2 0.0 0.5 2.3 -0.5 0.8
Weight 1.9 9.3 19.4 -2.4 3.3 2.8 -1.7 -4.4
Impedance of arm (right) 0.6 2.8 7.3 2.2 -0.7 -1.0 -0.2 2.7
Arm fat percentage (right) 2.2 8.7 14.4 -2.9 2.9 3.1 -1.5 -3.8
Trunk fat-free mass 0.5 2.8 6.7 -0.6 1.9 1.7 -0.8 -2.6
Hip circumference 2.1 9.2 18.7 -2.6 2.9 2.7 -2.1 -4.3
Time employed in main current job 0.6 0.7 1.0 -0.4 -0.8 -0.9 1.0 0.9
Alcohol intake versus 10 years previously 0.3 0.5 1.5 -0.4 0.5 1.2 -0.6 0.2
Father’s age at death 0.7 0.9 2.2 1.5 -0.2 -1.3 -0.6 0.5
Worrier / anxious feelings 0.4 0.7 1.8 -0.2 -0.3 -0.6 -1.3 1.0
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.7 6.0 -0.8 2.4 0.7 -1.3 -2.1
Falls in the last year 0.8 1.1 2.8 -0.8 -0.2 -0.6 -1.7 -1.1
Hair/balding pattern: Pattern 3 0.6 0.8 3.3 1.8 0.1 0.8 -0.5 0.2
Number of live births 3.2 4.5 11.2 -0.5 1.9 -0.9 -2.5 -3.4
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.4 1.6 -1.0 -1.2 -0.2 0.3
Pulse rate 0.3 0.6 1.1 -1.1 0.4 -0.9 -0.8 0.3
Happiness 0.8 1.0 2.6 1.6 -0.1 0.9 0.8 0.9
Noisy workplace 1.0 1.2 3.2 -0.2 1.8 0.6 0.1 -1.5
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.5 0.5 -1.9 -1.0 0.7 1.5
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 3.0 1.3 -0.2 1.7 -0.5 -1.1
Mouth/teeth dental problems: Dentures 0.3 0.5 1.4 1.2 0.8 0.5 0.3 -0.1
Asthma 0.1 0.2 1.1 -0.0 0.2 -0.2 1.0 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.6 -0.1 1.2 -0.4 -0.5 -1.2
Medication: Cholesterol lowering 1.1 1.7 6.6 0.6 0.7 2.6 -0.5 -0.8
Depression (self-reported) 0.8 1.0 1.8 1.0 0.0 1.3 -1.2 0.8
Medication: Lansoprazole 3.4 3.9 10.7 -1.9 0.8 -0.8 -3.3 -2.0
Prospective memory result 0.9 1.1 4.1 -2.0 0.9 0.6 -0.1 -0.5
Lung cancer (father) 1.8 2.1 3.5 -1.9 0.8 0.3 -1.7 -1.8
Illnesses of mother 0.6 0.7 1.9 1.4 -0.6 -1.1 0.0 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.1 0.7 -1.2 -1.4 -0.6 0.6
Pulse wave Arterial Stiffness index 0.2 0.3 0.8 -0.9 0.2 -0.5 0.4 0.4
Impedance of arm (left) 0.5 2.1 4.0 1.9 -0.6 -1.3 -0.8 2.0
Arm fat mass (right) 2.3 9.6 17.6 -2.7 3.1 3.3 -1.5 -4.2
Trunk predicted mass 0.5 2.8 6.4 -0.6 1.8 1.8 -0.7 -2.5
Standing height 0.3 2.6 9.8 3.1 1.1 1.1 -0.4 0.9
Length of working week for main job 0.5 0.5 1.7 -1.3 0.5 0.0 0.7 -0.5
Exposure to tobacco smoke at home 0.7 0.8 1.8 -0.7 1.2 -0.1 -0.6 -1.4
Breastfed as a baby 0.5 0.6 1.8 -0.6 -0.4 -0.4 -1.3 -0.7
Tense / ‘highly strung’ 0.7 1.1 4.3 -0.2 -2.1 0.8 -0.1 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 0.4 0.6 0.1 -0.9 -1.1
Hair/balding pattern: Pattern 4 0.2 0.5 1.0 -0.8 0.0 1.0 0.1 -1.0
Birth weight of first child 1.6 2.9 9.1 -3.0 0.5 -1.8 1.1 -0.8
Peak expiratory flow (PEF) 0.6 1.5 4.7 2.2 -1.1 -0.1 0.0 1.2
Pulse wave reflection index 0.6 0.7 2.3 0.7 0.8 1.5 -0.1 -0.3
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 -0.6 0.8 0.3 0.2 -0.0
Loud music exposure frequency 1.2 1.4 4.7 -1.0 0.7 -0.6 -0.2 -2.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.7 -1.6 -0.8 -0.0 0.0 0.0
Mouth/teeth dental problems: Bleeding gums 1.9 2.5 5.5 0.9 1.7 -0.6 -2.3 -1.7
Blood clot in the leg (DVT) 0.5 0.6 2.1 0.6 1.4 0.7 0.0 0.2
Medication: Paracetamol 1.6 2.6 5.3 -1.0 2.3 0.4 -1.4 -2.2
Headache pain in last month 0.9 1.5 3.8 -0.6 0.7 -1.2 -1.9 -1.2
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 6.2 -1.0 -1.2 -2.5 1.9 1.2
Glaucoma (self-reported) 0.9 1.0 2.3 0.3 -1.5 -0.8 0.3 1.5
Gout (self-reported) 0.9 1.2 3.1 -1.8 -1.1 1.0 -0.5 0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.7 0.2 0.7 0.5 1.6 0.9
Medication: Amlodipine 0.9 1.3 4.4 0.1 1.0 0.7 -0.8 -2.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.1 1.1 1.4 0.7 -0.1 -0.2
Birth weight 1.0 2.1 6.2 -1.7 0.4 -2.5 1.1 -0.1
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.5 0.6 0.8 1.2 0.1 -1.1
High blood pressure (siblings) 0.3 0.4 1.1 1.1 -0.2 -0.4 0.7 -0.4
Forced vital capacity (FVC), Best measure 0.3 1.0 1.9 1.4 -1.2 -1.1 0.2 0.7
Body fat percentage 1.9 7.3 13.3 -2.4 3.1 2.4 -1.5 -3.6
Leg fat percentage (right) 1.4 5.0 9.8 -1.8 2.4 2.2 -1.0 -3.1
Arm fat-free mass (right) 0.7 3.4 8.7 -1.1 1.9 1.7 -0.5 -3.0
Exposure to tobacco smoke outside home 0.6 0.8 1.7 -1.3 1.2 0.5 0.6 -0.7
Comparative body size at age 10 0.5 1.3 5.2 -2.3 0.0 -0.8 0.0 -0.7
Number of full brothers 1.1 1.3 3.6 -1.4 -0.4 -1.9 0.7 -0.7
Worry too long after embarrassment 2.7 4.5 8.2 2.2 -2.2 1.3 1.7 2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.0 1.4 -0.1 1.0 -1.4 -0.0
Wheeze or whistling in the chest in last year 4.6 8.3 14.4 -1.9 3.5 2.0 -2.7 -3.8
Number of children fathered 0.4 0.5 2.2 -0.2 -0.4 1.5 0.2 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 5.3 -0.5 -2.3 -0.8 -1.0 0.6
Age at first live birth 1.0 1.8 4.4 2.1 -0.9 -0.1 0.3 1.9
Pulse wave peak to peak time 0.4 0.4 1.3 1.1 -0.3 0.7 -0.5 -0.3
Health satisfaction 1.7 2.2 3.2 0.6 1.1 1.8 -1.7 -1.8
Shortness of breath walking on level ground 3.3 4.0 11.2 -1.2 1.9 1.4 -1.2 -3.4
Qualifications: College or University degree 1.6 4.9 9.0 2.4 -3.0 -1.5 0.1 2.7
Eye problems/disorders: None of the above 0.7 0.8 3.5 1.9 0.5 0.0 -0.0 -0.5
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.6 0.4 -0.8 -0.4 0.7 0.2
Emphysema/chronic bronchitis 0.7 0.8 1.3 -0.6 1.1 0.9 1.1 -0.6
Medication for pain relief, constipation, heartburn 2.2 3.8 9.0 0.1 -1.2 -1.7 3.0 2.4
Neck or shoulder pain in last month 0.6 0.8 1.4 -0.2 1.2 -0.2 -1.1 -1.1
Medication: Blood pressure 1.7 3.0 8.4 -0.0 1.8 2.9 -1.5 -1.1
Angina (self-reported) 1.7 2.2 6.9 -0.9 2.6 0.3 -1.0 -1.5
Migraine (self-reported) 0.4 0.5 1.8 -0.6 0.2 0.6 -1.3 0.1
Medication: Ibuprofen 1.1 1.3 3.2 0.4 1.8 -0.2 -1.1 -1.4
Medication: Allopurinol 0.6 0.8 2.4 -1.6 -0.8 0.7 -0.5 0.5
Medication: Omeprazole 0.5 0.6 1.7 1.3 -0.2 0.8 -0.6 0.8
Medication: Seretide 50 evohaler 1.8 2.0 6.4 2.5 -0.8 1.0 1.4 0.4
Mean time to correctly identify matches 0.8 1.6 4.3 -2.1 0.0 -1.7 -0.1 -0.7
Heart disease (mother) 0.3 0.4 1.1 -1.0 -0.4 -0.0 0.7 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.6 0.2 1.4 1.9 -0.8 -0.3
Whole body fat mass 1.9 7.9 14.7 -2.2 3.2 2.8 -1.3 -3.8
Leg fat mass (right) 1.8 7.0 12.9 -1.8 2.8 3.0 -1.3 -3.6
Arm predicted mass (right) 0.8 4.2 10.3 -1.5 2.5 1.5 -0.6 -3.2
Pulse rate, automated reading 0.2 0.7 1.2 -0.0 1.0 0.7 -1.0 1.1
Alcohol intake frequency. 1.1 2.5 8.6 0.5 1.8 2.9 0.5 0.1
Comparative height size at age 10 0.3 1.5 5.6 2.4 0.8 0.6 -1.0 -0.2
Number of full sisters 2.0 2.4 5.5 -0.4 1.2 2.3 -1.4 -1.7
Suffer from ‘nerves’ 0.3 0.5 1.0 -0.7 -0.0 1.0 -0.8 -0.4
Overall health rating 2.7 5.9 13.3 -0.5 3.2 3.6 -1.3 -2.0
Chest pain or discomfort 0.2 0.3 1.0 0.5 1.0 0.4 0.5 -0.1
Had major operations 1.1 1.3 3.4 1.1 -1.2 -0.1 -0.8 1.9
Age at last live birth 0.9 1.3 4.4 2.1 -0.2 0.5 -0.6 1.2
Family relationship satisfaction 0.3 0.3 0.9 0.2 0.3 1.0 0.1 -0.7
Leg pain on walking 1.8 2.3 5.4 -1.3 1.6 1.3 -0.4 -2.3
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 5.9 -1.4 1.3 -0.5 -0.4 -2.4
Commuting to job workplace: Car/motor vehicle 0.9 1.0 1.6 -1.2 1.2 0.2 -0.9 -1.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.9 -1.7 -0.0 -1.2 -0.1 0.7
Medication: Aspirin 1.2 1.6 2.3 1.5 0.1 1.5 -1.5 -1.1
Supplements: Vitamin C 1.5 1.7 2.6 1.1 1.5 0.7 -1.5 -1.6
Knee pain experienced in last month 0.1 0.1 0.2 0.4 -0.1 0.3 0.3 -0.5
Hypertension (Self-reported) 2.0 5.7 13.9 -1.6 1.0 3.7 -2.2 -2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.8 -0.6 -0.2 0.4 -1.4 0.6
Illnesses of father: Heart disease 0.9 1.3 3.0 1.0 1.7 1.3 -0.5 -0.8
Illnesses of siblings: Diabetes 0.4 0.5 1.5 -1.2 -0.1 -0.3 -0.2 -1.0
Smoking status: Previous 1.2 1.9 5.5 0.9 -2.4 0.2 1.4 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 1.4 1.2 -0.1 -0.0 -0.1 0.1
Whole body fat-free mass 0.8 4.5 10.3 -1.4 2.4 1.9 -0.9 -3.2
Leg fat-free mass (right) 1.3 7.2 15.3 -2.4 2.9 2.2 -1.3 -3.9
Arm fat percentage (left) 2.5 9.8 18.2 -3.0 3.0 3.0 -1.9 -4.3
Average weekly red wine intake 1.0 1.4 3.1 -1.8 -1.4 -1.1 -0.8 0.4
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.0 -1.0 -0.7 1.4 1.0 1.2
Mood swings 1.7 3.0 5.0 -0.8 2.0 1.6 -2.2 -1.8
Loneliness, isolation 2.2 3.1 7.6 0.5 2.8 1.6 -1.1 -1.9
Long-standing illness, disability or infirmity 1.7 2.6 7.0 0.1 2.6 2.0 -1.2 -0.9
Ever had bowel cancer screening 1.5 1.7 5.3 0.4 0.5 -2.3 -1.6 -0.4
Diabetes diagnosed by doctor 1.3 2.1 5.2 -1.6 2.3 1.5 -0.0 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.7 0.3 -0.2 -0.5 -0.5
Friendships satisfaction 0.5 0.7 1.7 0.4 0.3 -1.2 -1.3 -0.1
Qualifications: nursing, teaching 0.8 1.2 2.8 1.7 -1.0 -0.0 0.7 1.4
Commuting to job workplace: Walk 3.7 3.9 12.0 3.5 -2.6 0.2 -0.2 0.8
Eye problems/disorders: Cataract 1.7 2.0 9.4 -3.1 0.2 -0.8 -0.0 0.1
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 5.4 -0.6 0.7 -1.4 -1.8 -2.3
Medication for cholesterol 1.3 2.0 4.2 0.9 -0.8 -2.0 0.5 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.0 1.2 0.7 -0.4 -0.9 -1.4
Back pain experienced in last month 2.9 4.3 7.1 -1.4 2.7 1.4 -2.1 -2.5
Mineral and other dietary supplements 0.8 1.1 3.8 -1.9 0.1 -0.1 -0.1 -1.3
Breast cancer (self-reported) 0.5 0.6 1.9 1.4 -0.4 -0.3 -0.0 1.0
Asthma (self-reported) 0.1 0.2 1.1 0.2 0.2 -0.2 1.0 -0.0
Osteoporosis (self-reported) 0.4 0.4 1.5 0.8 0.2 -0.2 0.4 1.2
Osteoarthritis (self-reported) 0.6 0.8 3.0 -0.5 0.2 1.7 -0.6 -0.6
Medication: Aspirin 1.2 1.6 2.6 1.2 0.0 1.6 -1.5 -1.3
Medication: Gliclazide 0.5 0.5 1.1 -0.5 0.8 0.0 -0.8 -1.1
Illnesses of father: None of the above (group 1) 0.3 0.4 0.7 -0.8 -0.6 -0.5 0.2 0.7
Smoking status: Current 2.7 4.3 13.2 0.3 2.0 3.6 -0.7 -1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 4.3 -0.2 -0.4 -2.1 -1.0 0.2
Whole body water mass 0.8 4.5 9.9 -1.5 2.4 2.0 -0.8 -3.1
Leg predicted mass (right) 1.3 7.1 15.4 -2.4 2.9 2.1 -1.4 -3.9
Arm fat mass (left) 2.3 9.4 18.3 -2.5 3.1 3.3 -1.5 -4.3
Number of self-reported non-cancer illnesses 1.6 2.8 6.7 1.1 1.5 2.6 -1.9 -0.4
Average weekly champagne plus white wine intake 0.3 0.4 1.5 0.3 0.0 -1.2 -0.6 -0.4
Miserableness 0.7 1.2 4.5 0.3 0.9 2.1 -0.5 0.4
Guilty feelings 0.4 0.6 2.0 0.2 -0.7 1.4 -0.2 0.7
Wears glasses or contact lenses 0.4 0.5 1.8 -0.2 -0.2 -1.4 -0.5 0.3
Ever taken oral contraceptive pill 0.9 1.0 3.1 0.4 -0.3 -1.8 -0.9 -0.9
Hearing aid user 2.1 2.3 6.9 -2.6 0.3 -1.9 0.8 0.5
Mother’s age at death 0.8 1.0 2.0 1.0 -1.0 -0.5 0.9 1.4
Financial situation satisfaction 0.6 0.8 1.8 0.0 1.4 1.3 -0.5 -0.6
Tinnitus: Yes, now most or all of the time 0.7 0.9 2.5 1.0 -0.6 -0.2 1.6 0.6
Commuting to job workplace: Public transport 0.4 0.4 0.7 -0.6 0.8 -0.2 0.6 0.9
Eye problems/disorders: Glaucoma 0.4 0.4 0.9 0.7 -0.8 0.4 -0.1 1.0
Medication: Blood pressure 1.5 2.8 9.8 -0.8 0.6 3.1 -1.0 -1.5
Pain type(s) experienced in last month: Hip pain 3.1 3.9 5.9 -0.8 2.1 1.6 -2.4 -2.4
Supplements: Fish oil (including cod liver oil) 0.7 1.0 3.7 0.9 0.6 -0.0 -1.9 -0.2
High cholesterol (Self-reported) 2.2 3.8 5.6 0.7 2.4 1.7 -2.2 -2.3
Medication: Bendroflumethiazide 0.7 1.1 2.8 -0.2 -0.1 1.6 -1.7 -0.0
Medication: Paracetamol 1.7 2.7 5.8 -0.9 2.4 0.9 -1.3 -2.0
Medication: Lisinopril 0.3 0.4 1.4 0.0 0.3 1.2 -0.3 -0.6
Medication: Atorvastatin 2.5 3.1 6.7 -0.9 2.6 1.0 -1.6 -2.1
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.4 -0.5 -0.1 0.1 0.3
Alcohol drinker status: Never 1.2 1.5 3.1 -1.7 1.8 0.9 0.6 -0.1
Ever smoked 0.8 1.4 3.4 1.0 -1.9 1.3 0.8 0.5
Basal metabolic rate 1.1 6.0 12.9 -1.7 2.7 2.4 -1.1 -3.6
Leg fat percentage (left) 1.6 5.7 10.4 -2.2 2.7 2.3 -1.0 -3.2
Arm fat-free mass (left) 0.8 4.0 8.5 -1.3 2.4 1.9 -0.6 -2.9
Number of operations (self-reported) 0.3 0.4 0.9 0.6 -0.1 0.5 -1.0 0.5
Average weekly beer plus cider intake 0.6 0.8 1.9 0.1 1.4 1.0 0.4 -1.1
Irritability 1.0 1.7 2.7 1.6 0.2 1.6 -1.2 1.3
Risk taking 1.1 1.7 4.9 -1.6 0.9 -0.3 -0.3 -2.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.0 0.4 -0.4 -1.0 -0.4 0.5
Fractured/broken bones in last 5 years 1.0 1.3 4.6 -0.2 0.6 -0.9 -2.2 -0.8
Age started oral contraceptive pill 1.6 2.0 8.3 -0.1 -1.2 -2.9 0.3 0.5
Diastolic blood pressure, automated reading 0.3 1.1 4.1 1.0 0.3 2.0 -0.4 -0.3
Ever depressed for a whole week 3.1 3.9 6.6 2.1 -2.6 0.3 1.7 2.3
Unable to work because of sickness or disability 2.9 3.7 7.9 0.6 2.6 0.9 -2.8 -1.8
Commuting to job workplace: Cycle 0.4 0.5 1.9 1.4 0.6 -0.3 -0.1 0.5
Myopia 0.1 0.1 0.5 0.3 0.1 -0.1 0.7 -0.0
Vascular/heart problems diagnosed by doctor 1.9 5.3 13.4 1.4 -1.2 -3.7 2.0 2.4
Cholesterol lowering medication 1.8 2.6 7.4 0.2 1.8 0.9 -1.2 -2.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.1 0.5 -0.0 1.1 -0.9 0.4
Pain experienced in last month 1.2 2.1 3.5 0.6 -1.5 -0.9 1.9 1.9
Supplements: Calcium 0.7 0.7 1.4 1.2 -0.1 -0.5 1.1 1.0
Basal cell carcinoma (self-reported) 1.4 1.7 4.3 -0.9 1.0 -2.1 0.4 -1.5
Heart attack/myocardial infarction (self-reported) 2.4 3.1 7.4 -1.4 1.9 -0.1 -1.7 -2.7
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 2.3 0.8 1.5 0.6 0.1 0.3
Heart disease (siblings) 0.6 0.8 1.8 0.2 1.0 -0.2 -1.3 -1.0
Alcohol drinker status: Previous 1.2 1.3 4.3 0.8 0.6 1.0 -2.1 -0.7
Pack years of smoking 0.6 0.9 2.0 -1.0 0.8 0.6 -0.7 -1.4
Impedance of whole body 1.1 5.6 13.8 3.1 -1.5 -1.4 0.6 3.7
Leg fat mass (left) 1.9 7.3 13.3 -1.9 2.9 3.1 -1.2 -3.6
Arm predicted mass (left) 0.7 3.7 6.9 -1.1 2.2 2.2 -0.4 -2.6