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chr19:9,968,139-13,750,618

Best TWAS P=7.83e-17 · Best GWAS P=3.81e-15 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KRI1	0.30	0.39	lasso	3	0.38	1.7e-49	-5.5	5.6	2.4e-08	0.14	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	CDKN2D	0.21	0.12	lasso	5	0.09	1.2e-07	-6.7	6.7	2.8e-11	0.15	0.88	0.12	FALSE
3	GTEx	Brain Frontal Cortex BA9	KRI1	0.47	0.17	lasso	7	0.19	7.6e-06	-5.6	6.7	2.6e-11	0.15	0.31	0.25	FALSE
4	GTEx	Brain Hypothalamus	KRI1	0.29	0.17	lasso	3	0.20	1.5e-05	-5.5	5.4	7.5e-08	0.11	0.20	0.12	TRUE
5	GTEx	Cells EBV-transformed lymphocytes	PRDX2	0.26	-0.01	enet	41	0.06	6.9e-03	-3.5	-5.3	1.4e-07	0.02	0.04	0.06	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	FARSA	0.26	0.24	lasso	5	0.18	2.3e-06	4.8	5.1	2.9e-07	0.08	0.85	0.01	FALSE
7	GTEx	Cells Transformed fibroblasts	ACP5	0.07	0.04	lasso	3	0.03	1.9e-03	-5.3	-5.4	6.6e-08	0.02	0.50	0.06	TRUE
8	GTEx	Cells Transformed fibroblasts	MAN2B1	0.15	0.10	enet	17	0.08	2.7e-06	4.1	-5.8	5.9e-09	0.03	0.99	0.00	FALSE
9	GTEx	Cells Transformed fibroblasts	KRI1	0.18	0.16	enet	8	0.15	1.9e-11	-5.6	6.8	8.4e-12	0.15	0.99	0.01	FALSE
10	GTEx	Colon Sigmoid	KRI1	0.37	0.20	lasso	13	0.19	3.7e-07	-5.6	5.8	7.1e-09	0.20	0.56	0.19	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	RNASEH2A	0.21	-0.01	enet	20	0.00	4.7e-01	2.2	-5.5	3.1e-08	0.04	0.04	0.05	TRUE
12	GTEx	Esophagus Mucosa	SMARCA4	0.18	0.03	enet	15	0.09	8.2e-07	4.5	-5.5	3.4e-08	-0.09	0.94	0.01	FALSE
13	GTEx	Esophagus Muscularis	HOOK2	0.13	0.04	lasso	3	0.00	3.3e-01	5.9	-6.3	3.7e-10	-0.07	0.14	0.10	TRUE
14	GTEx	Muscle Skeletal	KRI1	0.14	0.07	lasso	4	0.11	5.1e-11	-5.6	7.0	3.1e-12	0.17	0.96	0.04	FALSE
15	GTEx	Muscle Skeletal	SLC44A2	0.19	0.18	lasso	5	0.19	5.1e-18	5.6	6.3	3.7e-10	0.17	1.00	0.00	TRUE
16	GTEx	Muscle Skeletal	CDKN2D	0.12	0.09	enet	14	0.08	1.5e-08	-6.7	5.9	2.9e-09	0.05	0.88	0.12	FALSE
17	GTEx	Nerve Tibial	MAN2B1	0.14	0.01	enet	57	0.03	4.0e-03	4.1	-5.4	8.0e-08	-0.02	0.60	0.05	FALSE
18	GTEx	Pituitary	GCDH	0.42	0.30	lasso	5	0.29	4.2e-08	5.9	5.6	2.2e-08	0.07	0.83	0.04	FALSE
19	GTEx	Small Intestine Terminal Ileum	CTC-425F1.4	0.26	0.13	enet	22	0.08	6.1e-03	2.7	-5.8	7.0e-09	-0.04	0.06	0.10	FALSE
20	GTEx	Spleen	MAN2B1	0.33	-0.01	enet	25	0.06	1.6e-02	3.6	-6.2	6.1e-10	-0.02	0.03	0.10	FALSE
21	GTEx	Testis	MAN2B1	0.18	0.07	enet	21	0.11	1.9e-05	3.5	-5.4	6.8e-08	0.01	0.90	0.00	FALSE
22	GTEx	Testis	CDKN2D	0.46	0.34	lasso	7	0.37	2.5e-17	-6.7	6.0	2.2e-09	0.13	0.91	0.09	FALSE
23	GTEx	Vagina	GCDH	0.36	0.01	lasso	5	0.00	3.3e-01	5.9	5.5	3.0e-08	0.02	0.05	0.05	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	SLC44A2	0.08	0.00	blup	365	0.01	1.4e-02	3.4	5.6	2.2e-08	-0.22	0.05	0.32	TRUE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	C19orf56	0.02	0.01	blup	23	0.01	1.0e-03	4.1	-5.8	6.5e-09	0.05	0.06	0.07	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNASE2	0.03	0.01	enet	9	0.01	5.5e-04	-7.5	-5.4	5.2e-08	-0.02	0.00	0.96	TRUE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	KRI1	0.03	0.02	blup	52	0.03	4.0e-06	-5.5	7.3	2.5e-13	0.08	0.05	0.95	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	KRI1	0.06	0.02	blup	51	0.02	2.1e-02	3.2	6.3	2.8e-10	0.14	0.02	0.43	TRUE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KRI1	0.06	0.06	lasso	1	0.06	5.3e-07	6.8	6.8	1.2e-11	0.11	0.02	0.97	TRUE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MAN2B1	0.02	0.01	blup	26	0.02	3.1e-03	4.5	-5.4	7.2e-08	0.02	0.04	0.10	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNASE2	0.04	0.01	enet	6	0.02	1.1e-03	-4.0	-5.3	9.4e-08	-0.09	0.02	0.06	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KRI1	0.05	0.05	blup	51	0.06	2.0e-07	-5.6	6.1	1.0e-09	0.13	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC147727	0.13	0.02	blup	28	0.04	7.2e-05	6.3	-6.3	3.5e-10	-0.09	0.02	0.72	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST1	0.03	0.00	blup	47	0.01	2.5e-02	-4.0	-5.7	1.3e-08	-0.12	0.03	0.04	TRUE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	KEAP1	0.16	0.03	blup	31	0.03	6.2e-03	-3.7	5.2	2.2e-07	-0.42	0.01	0.05	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	KRI1	0.09	0.04	blup	52	0.05	7.5e-04	-5.6	5.4	7.3e-08	-0.02	0.09	0.32	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC147727	0.07	0.02	lasso	2	0.02	5.4e-03	6.2	-6.5	6.5e-11	-0.15	0.02	0.66	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAN2B1	0.13	0.09	enet	14	0.12	4.4e-13	3.5	-5.8	6.3e-09	0.00	0.21	0.65	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	KRI1	0.05	0.04	blup	51	0.03	7.3e-05	6.9	8.3	7.8e-17	0.08	0.02	0.97	TRUE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C19orf56	0.42	0.00	lasso	5	0.00	1.1e-01	-4.0	-6.5	8.6e-11	0.03	0.00	0.09	FALSE
41	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	KRI1	0.32	0.15	enet	7	0.19	4.8e-08	-5.5	5.7	1.6e-08	0.12	0.22	0.64	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDKN2D	0.03	0.02	blup	48	0.01	2.1e-02	-5.6	6.5	6.1e-11	0.13	0.02	0.90	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	KRI1	0.12	0.14	blup	52	0.14	3.4e-14	-5.6	5.4	8.5e-08	0.05	0.88	0.12	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZGLP1	0.04	0.00	blup	48	0.02	3.5e-03	3.0	-5.5	4.9e-08	0.44	0.00	0.19	TRUE
45	The Cancer Genome Atlas	Soft Tissue Sarcoma	KRI1	0.05	0.06	lasso	3	0.04	3.1e-03	5.6	5.4	6.2e-08	-0.03	0.03	0.39	FALSE
46	The Cancer Genome Atlas	Soft Tissue Sarcoma	MAN2B1	0.40	0.08	blup	38	0.12	1.2e-07	3.1	-6.9	5.2e-12	0.01	0.57	0.26	TRUE
47	The Cancer Genome Atlas	Thyroid Carcinoma	SLC44A2	0.32	0.22	enet	14	0.25	3.8e-24	6.5	6.0	1.6e-09	0.07	0.14	0.86	FALSE