Hub : Genes

HDGFRP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.4370	0.1240	0.00550	-0.011	NA	-0.005	NA	0.000	9.0e-01	NA	0.4700	NA	0.31000
2	GTEx	Lung	0.1226	0.0406	0.00064	0.054	NA	0.031	NA	0.040	5.7e-05	NA	0.0019	NA	0.00051
3	GTEx	Nerve Tibial	0.1218	0.0488	0.00700	0.003	NA	0.012	NA	0.004	1.8e-01	NA	0.0430	NA	0.17000
4	GTEx	Thyroid	0.0800	0.0330	0.00990	0.054	NA	0.003	NA	0.035	5.5e-05	NA	0.1700	NA	0.00100
5	ROSMAP	Brain Pre-frontal Cortex	0.0304	0.0165	0.03400	0.023	0.007	0.011	0.007	0.020	5.8e-04	0.042	0.0130	0.032	0.00120

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	1.3	0.4	-0.1	-0.3	1.1	-0.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.2	-0.1	-0.1	0.4	-0.3
Depressed Affect (Nagel 2018)	0.4	0.9	2.2	-1.5	-0.8	-0.4	-1.0	0.8
Depression (Nagel 2018)	0.5	0.8	2.9	-1.7	-0.2	-0.0	0.4	0.9
Intelligence (Savage-Jansen 2018)	0.7	2.3	5.2	0.0	1.8	1.4	2.3	-1.2
Neuroticism (Nagel 2018)	0.3	0.8	1.8	-1.3	-1.0	0.2	0.1	1.0
Schizophrenia (2018)	0.1	0.1	0.3	-0.4	-0.1	0.2	-0.5	-0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	2.5	0.0	0.0	0.0	0.0	-1.6
Worry (Nagel 2018)	0.9	2.0	8.5	-2.9	-0.0	0.8	0.7	-0.2
Alzheimer’s Disease (in mother)	2.6	3.0	7.7	-0.5	2.8	0.5	1.1	-2.4
Alzheimer’s Disease (in father)	0.2	0.2	0.9	0.9	0.2	0.1	0.1	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.5	0.3	1.2	0.2	0.5	-0.8
Crohns Disease (2017)	0.3	0.7	1.3	0.9	-1.1	-0.0	-0.1	1.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.1	-0.2	-0.3	0.6	0.5
Ulcerative Colitis (UC)	0.4	0.7	1.3	-1.2	0.4	-0.9	1.0	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.3	0.6	1.2	-1.1	-0.4	-0.6	-1.1	0.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.7	-0.1	1.8	0.8	2.2	-1.1
Breast Cancer	1.2	2.8	7.9	2.8	-1.3	0.8	1.5	1.3
Ovarian Cancer	0.3	0.4	1.0	-1.0	0.7	-0.2	-0.4	-0.5
Prostate Cancer	0.4	0.5	1.9	0.7	-0.3	1.4	0.4	0.0
Age at First Birth	0.6	0.8	1.5	0.1	1.2	0.9	0.7	-1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	-1.0	0.5	-0.7	-0.8	-0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.7	3.4	1.9	-0.1	-0.1	0.2	0.1
Mean Putamen Volume	1.4	1.7	5.7	-2.4	-0.1	-1.5	-0.6	0.2
Fasting Glucose	2.0	2.4	4.6	-0.7	-2.1	-1.0	-1.2	2.1
HbA1C	1.1	1.2	3.6	-1.9	-0.3	-0.8	-1.1	0.8
HDL Cholesterol	0.9	1.6	4.9	-0.0	-1.2	-0.7	-2.2	1.0
LDL Cholesterol	3.3	5.2	11.5	-0.7	3.4	1.0	1.5	-3.3
Lupus	0.7	1.1	2.7	0.3	0.2	1.6	1.6	-0.2
Neuroticism (2016)	0.3	0.4	0.7	-0.9	0.7	0.5	0.5	-0.7
Primary Biliary Cirrhosis	3.2	4.6	8.0	-1.4	2.3	2.8	1.6	-2.3
Rheumatoid Arthritis	0.7	1.0	3.2	0.8	0.4	-0.0	-1.8	-0.9
Schizophrenia (2014)	0.1	0.2	0.4	-0.0	0.2	0.6	0.3	-0.4
Triglycerides	0.7	1.1	5.2	0.4	0.1	0.2	2.3	-0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.2	0.2	1.0	-0.4	0.2	-1.0	0.1	0.0
Blood Eosinophil Count	0.1	0.7	1.6	1.3	0.4	0.8	-0.8	-0.5
Blood Platelet Count	1.0	11.4	27.9	-0.7	4.7	0.7	-2.5	-5.3
Blood Red Count	2.1	20.6	56.1	1.4	4.0	-0.7	-7.5	-5.4
Blood White Count	0.1	0.9	2.7	1.6	-0.6	1.2	-0.2	-0.0
Heel T-Score	0.5	4.2	6.5	-1.3	2.4	1.6	2.5	-2.1
BMI	0.3	1.5	2.8	-1.1	1.3	-0.5	-1.7	-1.3
Height	0.3	5.7	22.6	1.1	1.7	-1.2	-4.8	-0.5
Waist Hip Ratio (WHR)	1.4	6.3	14.6	-0.7	-3.6	0.5	1.8	3.8
Systolic Blood Pressure	0.1	0.6	1.7	0.0	0.9	-1.3	-0.1	-0.8
Smoking Status	0.7	1.6	4.4	0.6	1.7	-0.2	-0.7	-2.1
Allergy or Eczema	1.5	4.0	7.8	-2.1	2.6	-0.6	0.5	-2.8
Cardiovascular Disease	1.3	4.1	10.4	-0.8	3.1	0.2	0.4	-3.2
Hypothyroidism (self reported)	0.4	0.8	3.7	-1.9	0.2	-0.2	-0.6	-0.0
Respiratory disease	3.2	7.1	17.8	-1.1	4.0	0.3	0.7	-4.2
Type 2 Diabetes (T2D) (2018)	1.7	3.3	6.9	0.5	2.1	-0.9	-2.0	-2.6
Lung FEV1/FVC ratio	0.5	2.8	6.1	0.9	-1.5	2.5	0.9	1.9
Lung FVC	0.2	1.0	2.2	0.4	-1.3	-1.0	0.3	1.5
Neuroticism	0.4	1.0	4.4	-2.1	-0.2	0.4	0.4	0.0
Chronotype (morning person)	0.5	1.1	2.1	0.8	-0.9	-0.8	1.4	1.2
Hair Pigment	0.2	4.5	6.4	-2.5	-2.3	-1.2	1.8	2.4
Tanning	0.1	1.6	3.0	0.6	-1.5	-0.8	-1.3	1.7
Hand grip strength (left)	0.4	1.0	1.7	1.1	-0.9	0.7	-0.9	1.3
Number of treatments/medications taken	2.0	3.7	6.8	-2.1	2.6	-0.3	0.8	-2.6
Average weekly spirits intake	0.7	0.9	1.6	0.1	-1.3	1.0	-0.2	1.3
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.9	0.6	-0.0	0.0	-0.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.4	0.6	-0.1	-0.5	-0.4
Hearing difficulty/problems: Yes	1.2	1.9	4.7	0.7	1.0	1.4	2.2	-1.1
Relative age of first facial hair	0.8	1.6	2.1	-1.4	1.3	1.1	1.1	-1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.8	-1.7	0.8	-0.5	0.4	-0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.3	0.8	-0.5	0.1	-0.6
Ever had hysterectomy (womb removed)	0.4	0.5	1.3	-0.2	1.0	-0.1	-0.1	-1.1
Systolic blood pressure, automated reading	0.4	1.2	2.0	0.8	1.2	-1.2	1.4	-0.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.5	1.0	0.9	-1.2	-1.0	-1.2
Angina	0.2	0.2	0.8	-0.9	0.2	0.3	-0.3	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.5	-0.3	-0.2	-0.2	0.2
Vitamin and mineral supplements	0.1	0.2	0.7	-0.8	0.2	0.1	0.2	-0.2
Supplements: Zinc	1.7	1.8	3.6	-1.1	1.0	-1.4	-1.9	-1.2
Medication: Co-codamol	0.6	0.6	1.5	0.6	0.5	1.2	1.0	-0.3
Medication: Metformin	1.1	1.6	5.0	-0.5	0.8	-2.2	-0.7	-1.2
Diabetes (father)	0.4	0.5	0.8	0.8	-0.9	0.8	-0.3	0.4
Diabetes (mother)	0.3	0.4	1.1	0.3	1.0	-0.4	-0.5	-0.8
Severe depression (siblings)	2.9	3.2	6.7	-1.0	2.5	1.4	0.4	-2.6
Pack years adult smoking proportion	0.9	1.3	2.8	0.7	-1.7	-0.4	-0.9	1.5
Impedance of leg (right)	2.4	11.4	20.5	-0.1	-4.5	2.0	3.5	4.5
Leg fat-free mass (left)	1.2	6.2	16.4	-0.1	2.5	-1.8	-4.1	-2.3
Trunk fat percentage	0.3	1.1	2.4	-1.5	0.8	0.6	1.2	-0.9
Hand grip strength (right)	0.3	0.8	1.9	0.5	-0.9	-0.6	-0.6	1.4
Townsend deprivation index at recruitment	0.5	0.7	3.2	1.8	-0.0	0.3	-0.4	-0.0
Current tobacco smoking	0.3	0.5	1.4	0.6	0.2	0.6	-1.2	-0.7
Average weekly fortified wine intake	0.6	0.7	2.3	0.6	0.5	1.5	-0.2	-0.8
Maternal smoking around birth	0.5	0.7	1.4	-0.7	1.1	-0.2	-0.3	-1.2
Fed-up feelings	0.3	0.6	2.1	-1.4	-0.2	0.2	-1.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.2	-0.5	0.7	-0.2	0.8
Relative age voice broke	1.2	1.8	5.8	-0.2	1.1	0.9	2.4	-1.1
Taking other prescription medications	1.6	2.5	4.7	-1.7	2.2	-0.7	0.1	-2.1
Age when periods started (menarche)	0.3	0.8	2.2	-0.4	0.8	1.5	0.2	-0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	0.3	0.2	-1.0	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	2.4	-1.5	1.4	1.6	0.6	-1.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.9	-1.0	-1.4	0.1	-0.3	1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.8	-1.0	0.4	-0.5	-1.4	-0.4
Serious illness, injury or assault to yourself	1.0	1.2	3.4	-1.9	0.6	-1.3	0.6	-0.5
High blood pressure	1.2	3.5	8.8	-0.1	3.0	-0.8	0.1	-2.8
Hayfever, allergic rhinitis or eczema	1.3	2.8	5.2	-2.3	1.9	-0.1	0.6	-2.1
Multivitamins +/- minerals	1.0	1.3	2.9	0.6	-1.6	-0.6	-0.5	1.7
Stomach or abdominal pain in last month	0.3	0.3	1.0	-1.0	-0.5	0.2	-0.4	0.4
Supplements: Glucosamine	0.6	0.7	1.6	1.0	0.2	-1.3	-0.9	-0.4
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	2.9	-0.6	1.5	-1.4	-1.4	-1.7
Medication: Atenolol	2.2	2.7	4.7	-0.4	2.2	1.2	2.1	-1.8
Medication: Levothyroxine sodium	0.4	0.7	2.2	-1.5	-0.5	-0.3	0.3	0.8
Sitting height	0.4	2.7	8.9	0.1	-1.3	-0.2	-3.0	1.6
Chronic bronchitis/emphysema (father)	2.1	2.4	4.7	2.2	-1.1	-1.9	-1.2	1.1
High blood pressure (mother)	0.6	0.9	1.2	0.2	-1.1	-1.0	1.0	1.1
Body mass index (BMI)	0.4	1.7	3.9	-0.1	1.9	-0.5	-0.7	-2.0
Impedance of leg (left)	2.5	12.0	23.6	-0.7	-4.8	1.4	3.2	4.9
Leg predicted mass (left)	1.2	6.3	17.1	-0.1	2.4	-1.9	-4.1	-2.2
Trunk fat mass	0.2	0.8	1.6	-1.0	1.3	0.1	-0.1	-1.2
Waist circumference	0.2	0.7	1.6	-0.6	1.3	-0.4	-0.3	-1.2
Number of incorrect matches in round	1.2	1.9	7.6	-0.9	0.2	-2.8	-0.8	-0.8
Past tobacco smoking	1.4	2.5	5.7	0.8	-2.4	1.1	0.4	2.2
Alcohol usually taken with meals	0.8	1.3	2.1	0.2	1.3	1.0	1.2	-1.5
Nervous feelings	1.0	1.9	5.1	-1.1	1.2	2.2	0.6	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.6	-0.3	0.3	-0.5	0.1
Hearing difficulty/problems with background noise	0.4	0.7	1.3	0.3	1.1	1.0	0.5	-1.0
Hair/balding pattern: Pattern 2	1.2	1.6	2.4	1.5	-1.3	-1.0	-1.2	1.2
Had menopause	0.6	0.8	1.5	-0.3	1.1	-0.7	1.2	-0.9
Had other major operations	2.0	2.5	5.9	0.1	2.4	0.8	1.0	-2.2
Forced vital capacity (FVC)	0.3	1.2	3.5	0.2	-0.9	-0.5	-1.9	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.4	-0.9	0.8	1.6	-0.1	-0.9
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	5.5	0.3	-1.4	-2.4	-1.6	1.4
Qualifications: None of the above	2.6	5.6	8.6	1.0	-2.9	-2.7	-1.6	2.9
Financial difficulties in last 2 years	1.3	1.8	5.6	2.4	0.2	0.5	-1.8	-0.1
Mouth/teeth dental problems	0.2	0.4	0.7	0.8	0.3	0.8	0.4	-0.4
Heart attack	0.8	1.1	1.8	-1.1	1.2	-0.1	1.4	-1.0
Allergy	2.0	4.7	10.0	2.1	-3.0	-0.0	-0.1	3.2
Pain all over the body in last month	0.5	0.6	2.2	0.5	-0.0	-0.3	-1.5	-0.5
Diabetes (self-reported)	2.4	3.7	6.5	-0.7	2.3	-1.9	-1.7	-2.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.3	-1.1	1.1	-0.3	-0.2	-1.1
Medication: Ramipril	1.0	1.3	2.4	0.7	1.6	0.8	1.0	-1.4
Medication: Simvastatin	3.7	5.4	8.1	-1.8	2.8	1.8	2.6	-2.4
Fluid intelligence score	0.4	0.8	1.4	0.5	1.1	0.7	1.2	-0.6
Illnesses of siblings	2.3	3.3	7.6	-0.4	-2.8	1.3	0.5	2.6
Neuroticism score	0.4	0.8	3.3	-1.8	0.3	0.3	-0.4	-0.4
Weight	0.5	2.4	4.5	0.1	2.0	-0.8	-2.1	-1.7
Impedance of arm (right)	1.1	5.3	14.3	-2.6	-1.1	1.8	3.8	1.0
Arm fat percentage (right)	0.6	2.5	4.6	-1.6	2.0	0.3	1.0	-2.1
Trunk fat-free mass	1.2	6.6	20.9	1.4	1.8	-2.2	-4.6	-1.3
Hip circumference	1.0	4.2	9.8	-0.1	3.1	-0.3	-1.4	-3.0
Time employed in main current job	0.3	0.4	0.8	-0.1	0.6	0.5	-0.6	-0.9
Alcohol intake versus 10 years previously	0.4	0.7	1.3	-0.8	0.7	0.9	1.1	-0.5
Father’s age at death	0.9	1.2	3.7	-0.9	-1.1	0.3	-1.9	0.5
Worrier / anxious feelings	0.5	1.0	4.2	-2.1	-0.7	0.2	-0.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.3	-0.5	0.1	1.1	-0.6	-0.4
Falls in the last year	0.6	0.8	1.8	-0.6	0.7	-0.2	-1.4	-1.0
Hair/balding pattern: Pattern 3	1.3	1.9	6.4	0.5	0.8	1.3	2.5	-0.9
Number of live births	0.3	0.4	1.2	-0.3	-0.6	-1.1	0.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.1	0.2	-1.4	0.2	-1.2	1.8
Pulse rate	1.1	1.8	3.5	-1.8	1.9	0.4	-0.0	-1.5
Happiness	2.4	2.9	8.9	3.0	-0.5	2.3	0.1	0.5
Noisy workplace	1.2	1.5	2.8	-0.8	1.4	0.6	1.7	-1.4
Qualifications: A levels/AS levels or equivalent	3.8	8.3	14.8	0.1	2.9	3.8	3.0	-3.1
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	5.9	-1.5	0.5	-1.2	-2.4	-1.1
Mouth/teeth dental problems: Dentures	0.3	0.6	1.5	-0.4	-0.6	-0.9	-0.1	1.2
Asthma	1.3	2.7	7.0	-0.2	2.3	-0.1	-1.1	-2.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.7	0.1	0.1	1.4	-1.6	-0.5
Medication: Cholesterol lowering	2.5	3.8	6.8	-2.3	2.6	0.4	1.4	-2.2
Depression (self-reported)	0.6	0.7	2.3	0.6	-0.8	0.1	-1.5	0.6
Medication: Lansoprazole	0.0	0.0	0.1	0.1	0.0	0.0	-0.1	-0.3
Prospective memory result	0.8	0.9	2.6	-1.3	0.2	-1.6	-0.1	-0.6
Lung cancer (father)	0.4	0.5	1.6	0.7	-0.1	-0.5	-1.2	0.1
Illnesses of mother	0.4	0.5	1.5	0.4	-0.2	1.2	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.2	-0.0	-1.3	-0.1	-1.8	1.7
Pulse wave Arterial Stiffness index	0.5	0.6	2.3	-0.8	0.0	-0.2	-1.5	0.1
Impedance of arm (left)	1.5	7.0	17.0	-2.3	-2.1	2.1	4.1	2.0
Arm fat mass (right)	0.5	1.9	4.0	-0.9	1.9	-0.5	-0.7	-2.0
Trunk predicted mass	1.2	6.7	21.2	1.4	1.8	-2.3	-4.6	-1.4
Standing height	0.2	2.0	9.2	0.2	0.4	-0.8	-3.0	0.4
Length of working week for main job	0.3	0.4	1.2	0.7	-0.1	1.1	-0.2	-0.1
Exposure to tobacco smoke at home	0.4	0.5	1.1	0.2	-0.6	0.5	-1.0	0.8
Breastfed as a baby	1.8	2.2	4.5	0.4	2.1	1.4	0.9	-2.0
Tense / ‘highly strung’	0.2	0.4	1.1	-1.0	0.0	-0.9	-0.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	-0.2	-0.8	-0.9	-1.1	0.6
Hair/balding pattern: Pattern 4	0.6	1.6	2.6	-1.4	0.7	-1.6	-1.6	-0.4
Birth weight of first child	0.5	0.8	2.2	0.1	-0.7	0.1	1.5	1.2
Peak expiratory flow (PEF)	0.3	0.6	1.4	-0.4	0.2	-1.2	-1.2	0.2
Pulse wave reflection index	1.2	1.5	2.3	-0.6	-1.5	-1.3	-0.9	1.5
Ever highly irritable/argumentative for 2 days	2.1	2.5	6.1	0.5	-1.4	-1.7	-2.5	1.2
Loud music exposure frequency	0.9	1.0	1.6	-1.3	1.1	-1.0	-0.4	-1.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	-0.4	1.0	0.6	0.1	-1.0
Mouth/teeth dental problems: Bleeding gums	3.0	3.9	5.3	2.3	2.1	2.1	0.9	-2.1
Blood clot in the leg (DVT)	0.7	0.8	1.2	-0.8	1.1	-0.4	-1.0	-1.1
Medication: Paracetamol	0.7	1.2	3.6	0.3	1.4	0.7	-0.1	-1.9
Headache pain in last month	0.7	1.2	2.4	-0.5	-1.5	0.9	-0.2	1.6
Medication for cholesterol, blood pressure or diabetes	2.9	4.7	10.2	1.9	-3.2	0.1	-1.1	3.0
Glaucoma (self-reported)	0.3	0.4	0.8	-0.5	-0.5	-0.7	-0.0	0.9
Gout (self-reported)	0.7	0.9	2.9	-1.7	0.0	-1.1	-0.7	-0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	3.2	-1.8	0.0	-0.3	-0.3	0.2
Medication: Amlodipine	1.2	1.7	4.2	0.5	2.0	-0.2	0.5	-1.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	-0.5	0.6	-1.2	-0.7	-0.7
Birth weight	1.7	3.7	6.4	-2.0	-1.3	-1.2	2.2	2.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	5.1	-0.9	0.2	-2.3	-0.6	-0.2
High blood pressure (siblings)	1.4	2.0	4.1	1.4	2.0	-0.8	-0.2	-1.8
Forced vital capacity (FVC), Best measure	0.4	1.6	5.1	-0.0	-0.8	-0.8	-2.3	1.2
Body fat percentage	0.2	0.8	1.6	-1.3	0.7	0.4	1.1	-0.8
Leg fat percentage (right)	0.1	0.2	0.7	-0.7	-0.2	0.1	0.8	-0.0
Arm fat-free mass (right)	1.3	6.4	21.8	1.9	1.1	-2.2	-4.7	-0.8
Exposure to tobacco smoke outside home	0.8	1.1	2.3	0.9	-0.8	-0.0	1.5	1.3
Comparative body size at age 10	0.7	1.9	2.8	-1.6	-1.4	-1.5	-0.2	1.7
Number of full brothers	1.0	1.2	2.2	0.5	1.3	0.7	-1.2	-1.5
Worry too long after embarrassment	0.1	0.1	0.4	0.7	0.1	0.3	0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	-0.8	1.0	0.9	0.3	-1.2
Wheeze or whistling in the chest in last year	2.1	3.8	11.1	-0.3	2.5	0.9	-0.8	-3.3
Number of children fathered	0.4	0.4	1.5	0.3	0.2	-1.2	-0.5	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	1.0	0.4	0.2	1.1	-0.4
Age at first live birth	0.6	1.0	1.8	-0.5	1.2	1.3	-0.5	-1.2
Pulse wave peak to peak time	0.5	0.5	1.9	0.9	0.0	0.2	1.4	-0.1
Health satisfaction	3.1	4.0	8.4	1.6	2.7	1.0	1.0	-2.9
Shortness of breath walking on level ground	0.9	1.0	1.7	-1.3	1.1	-0.7	0.8	-1.1
Qualifications: College or University degree	2.8	8.7	17.3	-2.6	3.9	1.2	1.7	-4.2
Eye problems/disorders: None of the above	0.4	0.4	1.0	-1.0	-0.1	-1.0	0.2	-0.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	0.0	0.8	0.5	-0.4	-1.1
Emphysema/chronic bronchitis	1.0	1.2	2.0	0.3	-1.4	-1.1	-0.8	1.4
Medication for pain relief, constipation, heartburn	0.5	0.9	2.0	1.4	-0.9	-0.2	0.4	1.3
Neck or shoulder pain in last month	1.2	1.6	2.9	-0.2	1.1	1.7	-1.5	-1.3
Medication: Blood pressure	2.1	3.7	8.5	-1.1	2.9	-0.1	1.4	-2.6
Angina (self-reported)	0.1	0.2	0.7	-0.8	0.0	0.2	-0.1	-0.0
Migraine (self-reported)	1.1	1.4	3.8	1.5	0.3	1.9	-0.8	-0.3
Medication: Ibuprofen	1.2	1.5	5.2	0.2	0.1	1.4	-2.3	-0.5
Medication: Allopurinol	0.9	1.1	2.5	-1.6	-0.1	-1.5	-1.0	0.2
Medication: Omeprazole	0.5	0.6	2.2	-0.6	0.3	0.3	1.5	-0.3
Medication: Seretide 50 evohaler	0.9	1.0	3.6	0.3	0.0	1.1	-1.9	-0.2
Mean time to correctly identify matches	0.2	0.3	0.6	-0.6	0.4	-0.3	-0.8	-0.5
Heart disease (mother)	0.5	0.7	1.1	0.2	0.9	1.1	0.8	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.3	1.3	-1.5	-1.0	-0.9	0.8
Whole body fat mass	0.2	0.9	1.7	-0.9	1.3	-0.2	-0.6	-1.3
Leg fat mass (right)	0.1	0.6	0.9	-0.8	0.8	-0.3	-0.7	-0.9
Arm predicted mass (right)	1.1	5.5	19.1	1.7	1.3	-1.8	-4.4	-1.0
Pulse rate, automated reading	1.4	4.6	8.7	-2.9	2.7	-0.3	-0.7	-2.5
Alcohol intake frequency.	0.1	0.3	0.8	0.5	0.4	0.9	-0.3	-0.5
Comparative height size at age 10	0.6	3.2	11.8	-0.6	0.2	-1.8	-3.4	0.5
Number of full sisters	0.6	0.7	1.4	0.1	0.5	1.0	1.2	-0.8
Suffer from ‘nerves’	0.3	0.5	2.1	-1.5	0.3	-0.2	-0.1	-0.7
Overall health rating	0.3	0.7	1.5	-0.1	0.7	1.0	-0.7	-1.2
Chest pain or discomfort	1.2	1.7	5.4	2.3	0.1	1.4	-0.9	-0.3
Had major operations	1.5	1.8	2.5	1.3	1.3	0.7	-1.6	-1.6
Age at last live birth	1.3	1.9	2.8	-1.5	1.2	1.7	-1.0	-1.5
Family relationship satisfaction	0.8	0.9	2.9	-0.2	-0.9	-0.9	-1.7	0.5
Leg pain on walking	1.5	1.9	4.5	0.1	2.1	0.2	0.5	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	3.1	-0.2	-1.8	-0.1	-1.5	1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.3	0.5	-0.7	-1.4	-1.8	0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.6	0.1	0.2	-0.3	1.6	0.1
Medication: Aspirin	1.6	2.0	3.6	-1.8	1.9	-0.3	0.0	-1.8
Supplements: Vitamin C	0.4	0.4	0.9	0.0	0.7	-0.5	0.9	-0.8
Knee pain experienced in last month	0.3	0.5	2.1	0.3	-0.0	0.4	-1.4	-0.0
Hypertension (Self-reported)	1.5	4.3	11.1	-0.1	3.3	-0.2	0.4	-3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.7	-0.3	-0.7	1.9	1.3	0.3
Illnesses of father: Heart disease	0.4	0.6	2.7	-1.6	0.4	0.1	0.4	-0.3
Illnesses of siblings: Diabetes	2.0	2.4	5.2	-0.3	2.2	-0.5	-1.3	-2.3
Smoking status: Previous	1.7	2.5	3.9	-1.4	2.0	-1.9	-0.2	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	-0.3	0.3	0.9	-0.4	0.0
Whole body fat-free mass	1.2	7.1	22.4	0.9	2.0	-2.3	-4.7	-1.6
Leg fat-free mass (right)	1.3	6.9	18.7	-0.2	2.4	-2.2	-4.3	-2.2
Arm fat percentage (left)	0.4	1.7	2.9	-1.4	1.5	0.3	1.0	-1.7
Average weekly red wine intake	1.2	1.8	3.1	-1.4	1.5	0.3	1.8	-1.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.5	-0.6	0.7	1.1	1.6	-0.3
Mood swings	0.4	0.8	2.5	-0.5	-0.7	-0.7	-1.6	0.5
Loneliness, isolation	0.4	0.5	1.3	0.1	0.7	1.2	-0.4	-0.9
Long-standing illness, disability or infirmity	0.8	1.2	2.1	-0.9	1.3	-1.0	-0.7	-1.4
Ever had bowel cancer screening	1.7	2.0	4.7	-0.3	1.8	-1.0	0.8	-2.2
Diabetes diagnosed by doctor	2.1	3.5	6.6	-1.1	1.8	-2.6	-1.5	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.6	8.3	-1.0	2.8	0.9	-0.6	-2.9
Friendships satisfaction	0.4	0.6	1.3	1.1	0.1	1.1	-0.1	-0.4
Qualifications: nursing, teaching	1.9	3.0	6.9	-0.6	2.6	-0.5	1.2	-2.4
Commuting to job workplace: Walk	0.3	0.3	1.1	-0.1	0.3	1.1	-0.3	-0.2
Eye problems/disorders: Cataract	0.4	0.4	1.8	-0.2	0.3	1.4	0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.7	-1.9	-1.1	-1.5	-0.9	0.7
Medication for cholesterol	2.3	3.4	6.3	1.2	-2.5	-0.4	-2.2	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	-1.1	0.5	-0.4	-1.5	-0.4
Back pain experienced in last month	0.6	0.9	2.3	-0.1	-0.3	-1.4	-1.5	0.5
Mineral and other dietary supplements	1.3	1.7	4.2	0.7	-2.0	-0.1	0.3	2.0
Breast cancer (self-reported)	0.6	0.7	1.0	-1.0	0.5	-0.9	-1.0	-0.7
Asthma (self-reported)	1.2	2.4	6.5	-0.3	2.2	-0.3	-0.8	-2.5
Osteoporosis (self-reported)	2.7	3.3	5.9	-1.4	2.0	-2.4	-1.3	-1.8
Osteoarthritis (self-reported)	1.4	1.9	3.9	0.9	1.1	1.5	2.0	-1.1
Medication: Aspirin	1.6	2.1	4.3	-1.5	2.1	-0.1	0.1	-2.0
Medication: Gliclazide	1.2	1.4	5.0	-0.2	0.4	-2.2	-1.1	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	1.6	0.2	-0.1	1.3	0.1	-0.1
Smoking status: Current	0.5	0.8	1.7	0.7	0.4	1.1	-1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	2.2	-0.0	-0.3	0.4	1.5	0.5
Whole body water mass	1.2	7.1	22.2	1.0	2.1	-2.2	-4.7	-1.7
Leg predicted mass (right)	1.3	7.0	19.1	-0.3	2.4	-2.3	-4.4	-2.2
Arm fat mass (left)	0.4	1.5	3.6	-0.6	1.8	-0.4	-0.6	-1.9
Number of self-reported non-cancer illnesses	1.6	2.8	4.3	-1.8	2.0	-1.1	-0.9	-2.1
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.0	0.4	0.1	-0.5	0.1
Miserableness	0.1	0.2	0.8	-0.2	-0.0	0.9	-0.6	0.1
Guilty feelings	0.5	0.7	1.4	0.9	-0.3	1.0	1.2	0.3
Wears glasses or contact lenses	1.8	2.1	3.8	-0.4	2.0	1.2	1.2	-1.9
Ever taken oral contraceptive pill	0.3	0.4	0.9	0.0	-0.9	-0.3	0.1	0.9
Hearing aid user	1.3	1.5	2.2	1.2	-1.3	1.3	0.7	1.5
Mother’s age at death	0.7	0.8	1.5	0.5	-0.6	-1.2	-1.2	0.9
Financial situation satisfaction	0.1	0.1	0.4	0.1	0.2	-0.6	-0.2	-0.4
Tinnitus: Yes, now most or all of the time	1.7	2.0	4.5	0.6	1.9	-0.1	1.2	-2.1
Commuting to job workplace: Public transport	1.5	1.8	3.9	-0.8	1.4	1.2	2.0	-1.1
Eye problems/disorders: Glaucoma	1.0	1.2	3.2	0.4	-1.5	-0.1	0.3	1.8
Medication: Blood pressure	1.8	3.4	6.8	-0.9	2.6	0.2	1.9	-2.4
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.3	-0.4	1.7	-0.7	-0.3	-1.8
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.6	0.3	1.8	0.8	-0.5	-1.9
High cholesterol (Self-reported)	2.1	3.7	6.4	-1.8	2.5	0.7	1.8	-2.3
Medication: Bendroflumethiazide	0.3	0.4	1.0	0.3	1.0	-0.3	0.1	-0.9
Medication: Paracetamol	0.6	0.9	2.5	-0.2	1.2	0.6	0.5	-1.6
Medication: Lisinopril	4.7	6.1	12.8	-2.3	3.6	-0.3	0.6	-3.4
Medication: Atorvastatin	0.4	0.5	2.1	1.5	0.4	-0.1	0.1	-0.3
Illnesses of father: High blood pressure	0.3	0.4	1.3	-1.2	0.4	-0.0	-0.3	-0.5
Alcohol drinker status: Never	2.6	3.1	7.3	1.3	-2.7	0.3	-0.8	2.5
Ever smoked	1.4	2.4	6.1	-0.5	2.5	-0.4	0.1	-2.4
Basal metabolic rate	1.0	5.8	17.9	0.7	2.0	-2.0	-4.2	-1.6
Leg fat percentage (left)	0.1	0.3	0.7	-0.8	-0.3	-0.2	0.7	0.1
Arm fat-free mass (left)	1.3	6.7	22.8	1.7	1.5	-2.1	-4.8	-1.2
Number of operations (self-reported)	1.4	2.0	3.9	0.8	2.0	1.6	-0.4	-1.7
Average weekly beer plus cider intake	1.1	1.7	2.8	0.7	-1.7	-0.4	-1.4	1.7
Irritability	0.5	0.8	1.4	0.4	-0.9	-1.2	-1.1	0.8
Risk taking	0.7	1.0	3.0	0.1	1.4	-0.3	0.2	-1.7
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	-0.9	0.8	-0.3	0.3	-1.0
Fractured/broken bones in last 5 years	0.7	1.0	2.0	-1.0	0.4	-1.2	-1.4	-0.6
Age started oral contraceptive pill	1.1	1.4	6.2	0.4	0.2	0.8	2.5	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	1.0	0.2	1.0	-1.0	-0.2	-0.4
Ever depressed for a whole week	1.0	1.2	3.8	1.9	-0.5	-0.2	-1.3	0.2
Unable to work because of sickness or disability	0.8	1.1	4.3	0.8	-0.7	-0.2	-2.1	0.3
Commuting to job workplace: Cycle	0.3	0.4	0.9	-0.3	-0.9	0.1	-0.4	0.9
Myopia	1.3	1.9	3.4	-1.9	1.5	-0.3	-0.9	-1.8
Vascular/heart problems diagnosed by doctor	2.0	5.3	13.2	0.5	-3.6	0.4	-1.2	3.4
Cholesterol lowering medication	3.6	5.3	10.1	-0.3	2.7	1.7	3.2	-2.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.8	-0.8	-0.0	0.5	1.7	-0.1
Pain experienced in last month	0.2	0.3	0.6	0.2	-0.6	-0.6	0.7	0.8
Supplements: Calcium	7.8	8.6	17.1	-3.1	3.5	-1.4	-1.4	-4.1
Basal cell carcinoma (self-reported)	2.6	3.1	3.8	1.6	-1.8	-1.7	-1.6	1.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.7	-1.0	0.9	-0.1	1.3	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	-0.8	0.9	-0.3	-1.3	-0.9
Heart disease (siblings)	2.3	2.8	4.9	-2.0	2.2	-0.3	1.3	-1.8
Alcohol drinker status: Previous	2.0	2.3	5.3	-2.3	1.6	-0.5	-0.0	-1.8
Pack years of smoking	0.5	0.7	1.6	0.6	-1.2	-0.3	-0.3	1.2
Impedance of whole body	1.9	9.6	14.3	-1.7	-3.8	1.9	3.7	3.7
Leg fat mass (left)	0.2	0.7	1.1	-0.9	0.9	-0.4	-0.7	-1.0
Arm predicted mass (left)	1.4	7.1	24.6	2.0	1.3	-2.0	-5.0	-1.1