TWAS hub - MKNK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1660	0.0540	0.0024	0.018	NA	0.094	NA	0.055	1.6e-02	NA	1.5e-07	NA	6.1e-05
2	YFS	Blood	0.1790	0.0229	0.0000	0.164	0.143	0.176	0.17	0.174	3.4e-51	1.5e-44	4.1e-55	3.3e-53	1.3e-54
3	TCGA	Breast Invasive Carcinoma	0.0339	0.0152	0.0010	0.007	0.015	0.022	NA	0.019	1.4e-02	4.3e-04	2.0e-05	NA	7.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Seen doctor (GP) for nerves, anxiety, tension or depression	4.7	7.1	14.2	-3.8	-2.7	-0.2
Wears glasses or contact lenses	3.7	4.2	7.9	-2.8	-2.0	-0.9
Guilty feelings	3.6	5.4	8.2	-2.9	-2.7	1.0
Pulse wave reflection index	3.3	4.1	6.6	2.3	2.6	-0.6
Medication: Seretide 50 evohaler	3.0	3.5	8.3	0.9	1.2	-2.9
Ever depressed for a whole week	2.9	3.6	6.6	-1.2	-2.6	-1.6
Alzheimer’s Disease (in father)	2.8	3.0	7.4	-1.2	-0.6	2.7
Ever used hormone-replacement therapy (HRT)	2.7	3.4	7.3	-2.7	-1.7	-0.1
Breastfed as a baby	2.7	3.4	5.7	-2.4	-0.5	-2.1
Ever had prostate specific antigen (PSA) test	2.7	3.1	6.1	-1.6	-2.5	0.7
Number of full brothers	2.5	3.2	7.2	-2.7	-1.5	-0.5
Commuting to job workplace: Cycle	2.5	3.0	4.3	-1.0	-1.9	-2.1
Blood Platelet Count	2.4	28.2	56.7	2.8	4.5	-7.5
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.9	5.0	-2.2	-1.9	-0.4
Friendships satisfaction	2.4	3.0	5.4	-1.7	-2.3	-1.0
Handedness (chirality/laterality): Left-handed	2.2	2.6	5.3	-1.6	-2.3	0.3
Ever had bowel cancer screening	2.2	2.6	2.8	-1.6	-1.7	1.6
Systolic Blood Pressure	2.1	10.7	16.9	4.1	3.8	-0.9
Number of full sisters	2.1	2.6	5.7	2.4	0.5	1.4
Long-standing illness, disability or infirmity	2.1	3.2	6.5	-2.6	-1.2	-1.2
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	2.8	-1.6	-1.7	-1.4
Diabetes (father)	1.9	2.4	2.8	1.7	1.5	1.4
Worry too long after embarrassment	1.8	3.0	6.9	-1.1	-2.6	1.0
Medication for cholesterol	1.8	2.8	3.9	-2.0	-1.8	-1.1
Breast cancer (self-reported)	1.8	2.1	3.9	-2.0	-1.3	0.9
Ovarian Cancer	1.7	2.3	5.2	0.8	2.3	-1.1
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.0	-1.7	-0.8	-1.5
Loud music exposure frequency	1.7	1.8	3.8	1.3	-0.2	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.8	2.2	1.1	0.1
Average weekly champagne plus white wine intake	1.7	2.4	6.9	-0.2	0.5	-2.6
Risk taking	1.7	2.5	3.2	1.6	1.8	1.3
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	2.7	-1.6	-1.4	1.2
Medication: Co-codamol	1.6	1.8	4.1	0.9	2.0	-0.8
Ever smoked	1.6	2.7	4.1	-1.9	-2.0	-0.7
Unable to work because of sickness or disability	1.6	2.1	3.4	-0.1	1.7	1.8
Primary Biliary Cirrhosis	1.5	2.1	6.2	-0.4	-0.0	-2.5
Chronotype (morning person)	1.5	3.6	7.6	-1.7	-2.8	0.4
Medication: Amlodipine	1.5	2.1	3.5	1.5	1.9	0.8
Eye problems/disorders: None of the above	1.5	1.7	4.6	-0.7	0.2	-2.1
Basal cell carcinoma (self-reported)	1.5	1.8	3.6	-1.4	-1.9	-0.1
Average weekly fortified wine intake	1.4	1.6	2.5	-1.6	-1.6	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	5.2	-2.3	-1.0	0.6
Blood clot in the leg (DVT)	1.4	1.8	2.4	-1.3	-1.5	1.1
High blood pressure (siblings)	1.4	2.0	4.0	-2.0	-0.4	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	2.3	1.5	0.6	1.5
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.6	1.9	1.3	-0.4
Intelligence (Savage-Jansen 2018)	1.3	4.1	6.6	-2.4	-2.6	0.2
Trunk fat percentage	1.3	5.2	10.9	-1.6	-1.5	3.3
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.5	-2.3	-0.7	0.2
Neuroticism score	1.3	2.8	3.6	-1.9	-1.9	1.1
Time employed in main current job	1.3	1.5	3.8	-0.7	0.1	-2.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.0	0.7	0.1	-2.0
Asthma	1.3	2.5	3.4	1.9	1.6	1.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	6.1	-0.3	-2.5	1.2
Chest pain or discomfort	1.3	1.8	3.0	-1.0	-1.2	1.7
Medication: Metformin	1.2	1.7	4.4	-0.7	0.5	-2.1
Maternal smoking around birth	1.2	1.8	2.5	-1.6	-1.6	0.7
Hip circumference	1.2	5.0	10.2	-2.0	-1.0	3.2
Prospective memory result	1.2	1.5	4.0	0.5	2.0	0.5
Length of working week for main job	1.2	1.4	1.6	1.3	1.3	0.9
Headache pain in last month	1.2	2.0	3.9	1.5	2.0	-0.2
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	3.9	1.4	-0.1	2.0
Body fat percentage	1.2	4.8	9.1	-1.7	-1.5	3.0
Illnesses of siblings: Diabetes	1.2	1.4	3.5	-0.6	-0.6	1.9
Asthma (self-reported)	1.2	2.3	2.9	1.7	1.6	1.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	1.8	-1.2	-1.4	1.2
Relative age of first facial hair	1.1	2.2	4.8	1.3	0.3	-2.2
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.3	0.6	1.8	0.3
Angina	1.1	1.5	3.1	-0.9	-0.8	1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.0	2.2	1.4	-0.6
Medication: Atenolol	1.1	1.4	2.8	-0.5	1.7	1.0
Trunk fat mass	1.1	4.7	7.8	-2.0	-1.6	2.8
Happiness	1.1	1.3	3.5	-0.7	-1.9	0.0
Pulse wave peak to peak time	1.1	1.3	3.4	-0.1	-1.8	0.8
Comparative height size at age 10	1.1	5.8	12.5	-3.5	-1.0	2.0
Supplements: Vitamin C	1.1	1.3	2.7	-0.9	-0.7	1.6
Illnesses of father: Heart disease	1.1	1.5	4.0	-0.6	-0.2	2.0
Smoking status: Current	1.1	1.7	4.3	-2.1	-0.2	0.9
Hearing aid user	1.1	1.3	2.3	1.2	0.1	1.5
Medication: Blood pressure	1.1	2.1	3.5	1.5	1.9	0.7
Leg fat mass (left)	1.1	4.2	6.1	-2.0	-1.6	2.5
Depression (Nagel 2018)	1.0	1.5	3.3	-1.8	1.1	-0.4
Blood Red Count	1.0	9.2	23.9	-4.9	-1.9	-0.3
Hypothyroidism (self reported)	1.0	2.2	4.1	-0.2	-1.6	2.0
Fed-up feelings	1.0	1.8	4.3	-2.1	-1.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.2	2.3	1.2	0.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.7	0.4	-1.0	1.6
Fluid intelligence score	1.0	2.1	5.2	-0.5	-2.3	-1.0
Qualifications: A levels/AS levels or equivalent	1.0	2.1	3.3	0.4	-1.7	1.8
Lung cancer (father)	1.0	1.2	2.8	-1.7	-0.7	0.5
Angina (self-reported)	1.0	1.4	3.3	-0.6	-0.6	1.8
Whole body fat mass	1.0	4.0	7.0	-1.8	-1.4	2.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	3.5	-1.2	-1.3	1.9
Arm fat percentage (left)	1.0	4.0	7.2	-1.4	-1.7	2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	6.1	-0.1	0.4	-2.5
Fractured/broken bones in last 5 years	1.0	1.3	3.1	0.3	0.8	1.8
Cholesterol lowering medication	1.0	1.4	3.8	0.1	0.7	1.9
Worry (Nagel 2018)	0.9	2.0	4.3	-2.1	-0.9	0.8
Ulcerative Colitis (UC)	0.9	1.6	3.4	0.9	1.8	0.8
Heel T-Score	0.9	7.0	19.5	4.4	1.2	0.4
Smoking Status	0.9	2.1	3.5	-1.9	-1.7	0.3
Respiratory disease	0.9	1.9	4.4	1.1	2.1	0.5
Lung FEV1/FVC ratio	0.9	4.3	4.7	-2.1	-2.0	2.2
Neuroticism	0.9	2.2	2.2	-1.5	-1.5	1.4
Severe depression (siblings)	0.9	1.0	1.5	-1.2	-1.1	0.6
Current tobacco smoking	0.9	1.5	4.1	-2.0	-0.2	0.7
Relative age voice broke	0.9	1.3	3.9	2.0	0.3	-0.0
Past tobacco smoking	0.9	1.7	3.4	1.2	1.9	0.6
Had menopause	0.9	1.1	1.7	-1.3	-1.2	0.3
Arm fat percentage (right)	0.9	3.7	6.6	-1.2	-1.7	2.6
Depression (self-reported)	0.9	1.1	2.7	-1.6	-0.8	0.2
Illnesses of mother	0.9	1.1	2.8	0.3	1.7	-0.7
Pulse wave Arterial Stiffness index	0.9	1.1	3.0	-0.1	1.7	-0.5
Arm fat mass (right)	0.9	3.5	6.2	-1.5	-1.5	2.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.3	1.2	-1.5	0.7
Leg fat mass (right)	0.9	3.6	5.4	-1.7	-1.5	2.3
Pulse rate, automated reading	0.9	3.0	6.6	-2.6	-1.1	1.1
Qualifications: nursing, teaching	0.9	1.5	3.0	1.7	-1.1	0.1
Medication: Aspirin	0.9	1.1	3.1	0.5	1.7	-0.1
Medication: Gliclazide	0.9	1.0	2.3	-1.5	-0.4	-0.7
Arm fat mass (left)	0.9	3.5	6.2	-1.5	-1.4	2.5
High cholesterol (Self-reported)	0.9	1.6	2.8	-1.0	-1.0	1.7
Illnesses of father: High blood pressure	0.9	1.1	1.8	1.0	1.3	-0.6
Supplements: Calcium	0.9	1.0	1.9	0.1	-1.1	1.4
Neuroticism (Nagel 2018)	0.8	1.8	4.2	-2.0	-0.7	0.9
Irritable Bowel Disease (IBD)	0.8	2.0	4.8	0.7	2.2	0.8
Pain all over the body in last month	0.8	0.9	1.8	-0.7	-0.6	1.4
Illnesses of siblings	0.8	1.1	2.0	1.4	0.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.8	-0.6	-1.0	-1.3
Exposure to tobacco smoke at home	0.8	0.9	1.4	0.2	1.2	-1.2
Tense / ‘highly strung’	0.8	1.3	2.0	-1.4	-0.7	1.2
Gout (self-reported)	0.8	1.2	1.9	-0.7	-1.1	1.4
Leg fat percentage (right)	0.8	3.0	4.1	-2.0	-1.5	1.6
Alcohol intake frequency.	0.8	1.8	4.0	1.0	2.0	0.8
Suffer from ‘nerves’	0.8	1.2	1.7	-1.3	-1.2	0.6
Age at last live birth	0.8	1.1	2.2	1.0	1.5	-0.4
Smoking status: Previous	0.8	1.1	3.1	-0.0	-1.8	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.1	-0.5	-0.5	-1.5
Eye problems/disorders: Cataract	0.8	0.9	2.2	0.6	-0.3	1.5
Financial situation satisfaction	0.8	1.0	1.4	-1.2	-1.1	0.4
Leg fat percentage (left)	0.8	3.0	4.5	-2.1	-1.3	1.6
Irritability	0.8	1.4	2.6	-1.1	-1.6	0.6
Neuroticism (2016)	0.7	1.1	1.8	-1.2	-1.3	-0.2
Lung FVC	0.7	3.5	8.6	1.4	-0.3	-2.9
Supplements: Zinc	0.7	0.8	1.2	-0.9	0.7	-1.1
Townsend deprivation index at recruitment	0.7	1.0	1.9	-1.4	-0.3	-1.0
Waist circumference	0.7	2.4	5.5	-0.8	-1.0	2.4
Mouth/teeth dental problems	0.7	1.1	3.0	1.7	0.6	-0.2
Mouth/teeth dental problems: Dentures	0.7	1.2	3.3	-1.8	0.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	-1.4	-0.7	0.3
Health satisfaction	0.7	0.9	2.4	-0.2	-1.6	0.6
Medication for pain relief, constipation, heartburn	0.7	1.1	2.1	0.2	-1.4	1.1
Migraine (self-reported)	0.7	0.9	1.8	0.1	1.3	-0.9
Mean time to correctly identify matches	0.7	1.4	2.4	-1.5	-1.3	-0.1
Diabetes diagnosed by doctor	0.7	1.2	2.2	-0.1	1.1	-1.5
Mineral and other dietary supplements	0.7	1.0	1.8	0.8	1.4	-0.8
Osteoporosis (self-reported)	0.7	0.9	1.5	1.2	-0.4	1.0
Ever taken oral contraceptive pill	0.7	0.7	1.6	-0.8	-1.2	-0.2
Mother’s age at death	0.7	0.9	2.2	-0.6	0.1	-1.5
Medication: Lisinopril	0.7	0.9	1.6	0.5	1.3	0.9
Average weekly beer plus cider intake	0.7	1.0	1.8	0.1	1.0	-1.3
Pack years of smoking	0.7	1.1	1.5	-1.2	-1.0	0.9
Prostate Cancer	0.6	0.9	1.8	-1.4	-0.9	-0.3
Lupus	0.6	0.8	1.9	-0.8	-1.4	-0.1
Average weekly spirits intake	0.6	0.8	1.6	0.3	0.8	1.3
Hearing difficulty/problems: Yes	0.6	1.0	1.9	1.4	0.9	-0.4
Systolic blood pressure, automated reading	0.6	1.9	4.1	0.6	1.1	-2.0
Pack years adult smoking proportion	0.6	1.0	1.1	-1.0	-1.0	1.0
Medication: Levothyroxine sodium	0.6	1.0	1.9	0.3	-1.4	1.0
Birth weight of first child	0.6	1.0	2.8	0.3	-0.5	1.7
Medication: Paracetamol	0.6	0.9	2.3	0.7	1.5	-0.2
Emphysema/chronic bronchitis	0.6	0.7	1.1	-0.3	1.0	1.0
Medication: Ibuprofen	0.6	0.7	1.1	-0.0	-0.9	-1.1
Medication: Omeprazole	0.6	0.7	1.6	0.7	1.3	0.0
Overall health rating	0.6	1.2	1.7	-1.3	-0.9	1.1
Medication: Aspirin	0.6	0.7	2.1	0.3	1.5	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.0	1.0	0.7	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	0.8	-0.6	-0.9	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.6	-0.8	-1.3	0.2
Myopia	0.6	0.9	1.9	-0.5	-0.8	-1.4
Alcohol drinker status: Previous	0.6	0.7	1.1	-0.6	1.1	-0.8
Depressed Affect (Nagel 2018)	0.5	1.0	2.7	-1.6	-0.0	0.5
Fasting Glucose	0.5	0.6	1.0	-0.4	1.0	0.7
Height	0.5	8.8	19.9	-4.5	-2.4	0.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	0.9	-0.9	0.7	-0.9
Taking other prescription medications	0.5	0.8	2.2	-1.5	-0.4	0.2
Qualifications: None of the above	0.5	1.1	2.9	-1.7	0.4	-0.5
Weight	0.5	2.5	4.9	-1.4	-0.8	2.2
Noisy workplace	0.5	0.6	1.5	1.2	0.6	0.1
Age at first live birth	0.5	0.9	2.0	1.4	0.8	0.1
Neck or shoulder pain in last month	0.5	0.7	1.2	0.8	1.1	-0.5
Heart disease (mother)	0.5	0.6	1.3	0.7	-1.1	-0.1
Osteoarthritis (self-reported)	0.5	0.7	1.2	-1.1	0.1	0.9
Medication: Paracetamol	0.5	0.8	1.6	0.6	1.2	-0.7
Diastolic blood pressure, automated reading	0.5	1.5	2.6	-1.6	-0.6	-1.2
Verbal and Numeric Reasoning (VNR)	0.4	0.8	1.3	-0.9	-1.1	-0.7
Mean Putamen Volume	0.4	0.5	1.3	0.4	0.1	-1.1
BMI	0.4	2.3	6.7	-0.3	-0.3	2.6
Waist Hip Ratio (WHR)	0.4	1.8	5.1	2.3	0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.4	-1.2	0.3	-0.5
Sitting height	0.4	2.7	3.2	-1.8	-1.5	1.6
Nervous feelings	0.4	0.8	1.4	-0.8	-1.2	0.5
Hearing difficulty/problems with background noise	0.4	0.6	1.2	-0.8	-1.1	-0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	1.1	-0.6	-0.0
Medication: Simvastatin	0.4	0.5	1.5	-1.2	0.4	-0.0
Worrier / anxious feelings	0.4	0.8	1.2	-0.9	-1.1	-0.5
Medication: Cholesterol lowering	0.4	0.7	1.9	-1.4	-0.2	-0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.2	-1.1	-0.2	-0.5
Qualifications: College or University degree	0.4	1.2	3.3	0.5	-0.4	1.8
Medication: Blood pressure	0.4	0.7	2.0	-0.4	0.2	-1.4
Leg pain on walking	0.4	0.5	1.3	0.3	-0.4	1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	1.2	0.3	-0.3
Average weekly red wine intake	0.4	0.5	0.9	0.3	-0.8	0.9
Alcohol drinker status: Never	0.4	0.5	0.7	-0.8	0.6	0.7
Heart disease (siblings)	0.4	0.6	1.6	-0.3	-1.2	-0.0
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	1.0	0.4	0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	0.4	-0.0	1.1
Age at First Birth	0.3	0.5	1.0	0.3	-0.5	-1.0
Blood White Count	0.3	2.1	3.5	-1.9	-1.1	-1.3
Hand grip strength (right)	0.3	0.7	1.3	-0.9	-1.1	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	0.5	1.3	0.1
Multivitamins +/- minerals	0.3	0.3	0.5	-0.7	0.7	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.3	-0.7	0.7
Body mass index (BMI)	0.3	1.1	3.0	-0.4	-0.4	1.7
Allergy	0.3	0.7	1.2	0.2	-0.9	-1.1
Diabetes (self-reported)	0.3	0.4	0.8	-0.9	0.3	-0.6
Falls in the last year	0.3	0.4	1.0	-0.2	1.0	0.5
Medication: Lansoprazole	0.3	0.3	0.7	-0.3	-0.9	0.2
Impedance of arm (left)	0.3	1.3	2.1	-0.7	-1.1	1.5
Hair/balding pattern: Pattern 4	0.3	0.6	1.3	-0.8	-1.1	-0.1
Peak expiratory flow (PEF)	0.3	0.6	1.0	0.8	-1.0	0.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.5	-0.4	-0.7	0.7
Comparative body size at age 10	0.3	0.8	1.9	-0.4	-1.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	-1.1	-0.1	0.2
Family relationship satisfaction	0.3	0.3	0.9	0.9	0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	-0.1	0.6	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.5	0.7	0.7	-0.5
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	-0.9	-0.3	0.7
Commuting to job workplace: Public transport	0.3	0.4	0.5	-0.7	0.5	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.5	0.8	0.6
Reaction Time	0.2	0.3	0.5	-0.6	-0.7	0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	0.3	1.1	-0.3
Tanning	0.2	2.4	4.6	-1.4	-0.8	-2.1
Hand grip strength (left)	0.2	0.5	0.7	0.8	-0.3	0.8
Sensitivity / hurt feelings	0.2	0.3	0.5	0.5	0.7	0.4
Ever had hysterectomy (womb removed)	0.2	0.3	0.4	-0.5	-0.6	0.3
Vitamin and mineral supplements	0.2	0.3	0.5	0.7	-0.2	-0.6
Diabetes (mother)	0.2	0.3	0.4	-0.5	-0.5	0.6
Leg fat-free mass (left)	0.2	0.9	2.5	-0.4	-0.0	1.6
Supplements: Glucosamine	0.2	0.3	0.7	0.5	-0.8	0.0
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.1	-0.7	0.3
High blood pressure (mother)	0.2	0.3	1.0	-0.1	-1.0	-0.0
Impedance of leg (left)	0.2	0.8	1.9	-1.4	-0.5	0.3
Leg predicted mass (left)	0.2	0.8	2.2	-0.4	-0.0	1.5
Number of incorrect matches in round	0.2	0.4	1.1	-1.1	0.2	-0.0
Alcohol usually taken with meals	0.2	0.3	0.5	-0.7	-0.4	-0.4
Forced vital capacity (FVC)	0.2	0.8	1.8	0.4	-0.5	-1.4
Financial difficulties in last 2 years	0.2	0.2	0.5	0.1	-0.7	0.4
Medication: Ramipril	0.2	0.2	0.6	0.8	0.1	-0.1
Impedance of arm (right)	0.2	1.0	2.3	-0.1	-0.9	1.5
Father’s age at death	0.2	0.3	0.5	-0.4	-0.7	0.5
Hair/balding pattern: Pattern 3	0.2	0.2	0.6	-0.2	-0.3	0.8
Standing height	0.2	2.0	4.3	-2.1	-0.4	1.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.4	-0.2	0.6
Glaucoma (self-reported)	0.2	0.2	0.5	0.3	0.7	0.1
Forced vital capacity (FVC), Best measure	0.2	0.7	1.5	0.7	-0.0	-1.2
Arm fat-free mass (right)	0.2	1.0	1.5	-1.2	0.2	1.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.1	-0.1	0.3	1.0
Arm predicted mass (right)	0.2	0.8	1.6	-1.3	0.2	0.9
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	-0.4	-0.5	-0.7
Medication: Bendroflumethiazide	0.2	0.2	0.4	0.2	0.5	-0.6
Medication: Atorvastatin	0.2	0.3	0.4	0.1	0.7	0.6
Arm fat-free mass (left)	0.2	1.0	1.5	-1.2	0.1	1.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.7	0.1	-0.5
Impedance of whole body	0.2	1.1	1.5	-0.9	-1.0	1.2
Arm predicted mass (left)	0.2	1.1	2.6	-0.9	0.2	1.6
Crohns Disease (2017)	0.1	0.3	0.8	-0.3	0.9	0.1
HbA1C	0.1	0.1	0.3	-0.1	-0.3	-0.5
Blood Eosinophil Count	0.1	0.9	2.5	0.2	0.6	-1.6
Allergy or Eczema	0.1	0.3	0.4	-0.6	0.6	-0.2
Cardiovascular Disease	0.1	0.3	0.4	0.6	0.6	0.5
Number of treatments/medications taken	0.1	0.2	0.5	-0.4	0.7	-0.2
Medication for hormone replacement therapy	0.1	0.1	0.1	0.0	0.2	-0.4
Impedance of leg (right)	0.1	0.6	1.4	-1.2	-0.6	0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.2	-0.3	0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.4	-0.3	0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.0	0.2	0.5
High blood pressure	0.1	0.3	0.8	-0.4	0.1	-0.9
Stomach or abdominal pain in last month	0.1	0.1	0.1	0.3	0.3	0.1
Had other major operations	0.1	0.1	0.2	-0.1	0.4	-0.4
Heart attack	0.1	0.1	0.2	-0.4	0.1	-0.2
Trunk fat-free mass	0.1	0.3	0.8	-0.9	0.5	0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.3	-0.5	-0.0
Number of live births	0.1	0.2	0.5	0.3	0.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	0.1	-0.7	-0.3
Pulse rate	0.1	0.2	0.4	-0.6	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	0.5	-0.4	-0.4
Trunk predicted mass	0.1	0.3	0.7	-0.9	0.5	0.1
Birth weight	0.1	0.2	0.4	0.6	0.5	-0.0
Number of children fathered	0.1	0.1	0.2	0.2	0.1	0.4
Shortness of breath walking on level ground	0.1	0.2	0.3	0.3	0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.0	-0.5	-0.3
Medication: Allopurinol	0.1	0.2	0.3	-0.5	0.3	0.4
Had major operations	0.1	0.1	0.2	-0.4	-0.2	-0.3
Knee pain experienced in last month	0.1	0.2	0.4	-0.1	0.6	-0.5
Hypertension (Self-reported)	0.1	0.3	0.5	-0.2	0.6	-0.7
Whole body fat-free mass	0.1	0.4	0.7	-0.6	0.4	0.9
Leg fat-free mass (right)	0.1	0.7	2.0	-0.4	0.1	1.4
Loneliness, isolation	0.1	0.1	0.3	0.1	0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.5	0.1	-0.5
Back pain experienced in last month	0.1	0.1	0.2	-0.1	0.2	0.4
Whole body water mass	0.1	0.5	0.7	-0.8	0.2	0.9
Leg predicted mass (right)	0.1	0.8	2.1	-0.4	-0.0	1.5
Miserableness	0.1	0.2	0.4	-0.3	-0.6	-0.2
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	-0.3	0.1	-0.6
Basal metabolic rate	0.1	0.8	1.8	-0.8	0.1	1.3
Age started oral contraceptive pill	0.1	0.1	0.2	-0.4	-0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.4	-0.3	0.7
Pain experienced in last month	0.1	0.2	0.7	-0.9	-0.0	-0.0
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2018)	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Breast Cancer	0.0	0.1	0.1	0.2	0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.1	0.2	0.2	0.1	0.5
Age when periods started (menarche)	0.0	0.1	0.2	0.1	0.5	-0.3
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	0.3	0.3	0.1
Mood swings	0.0	0.1	0.2	-0.4	-0.1	0.3
Commuting to job workplace: Walk	0.0	0.0	0.1	0.2	-0.3	-0.2
Number of operations (self-reported)	0.0	0.1	0.1	-0.0	0.3	-0.3

Hub : Genes

MKNK2

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Trait associations