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chr22:18,193,707-20,330,744

Best TWAS P=6.25e-34 · Best GWAS P=4.09e-40 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Artery Aorta	ARVCF	0.30	0.22	lasso	3	0.23	6.0e-13	12.22	-12.1	6.3e-34	0.01	1.00	0.00	TRUE
31	The Cancer Genome Atlas	Thyroid Carcinoma	ARVCF	0.05	0.02	enet	8	0.02	2.3e-03	8.14	9.8	8.1e-23	-0.05	0.03	0.90	TRUE
9	GTEx	Brain Cerebellum	AC006547.13	0.24	-0.01	enet	15	0.00	3.4e-01	6.63	9.6	8.0e-22	0.04	0.06	0.09	TRUE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARVCF	0.04	0.00	blup	116	0.00	1.8e-01	12.22	-9.1	1.1e-19	-0.02	0.01	0.66	TRUE
27	YFS	Blood	COMT	0.05	0.01	bslmm	495	0.03	7.7e-09	2.29	6.7	2.1e-11	0.01	0.79	0.00	TRUE
28	YFS	Blood	DGCR14	0.28	0.10	lasso	8	0.13	3.4e-39	-6.07	6.3	3.6e-10	0.03	0.00	1.00	TRUE
19	GTEx	Nerve Tibial	ZDHHC8	0.21	0.00	enet	24	0.04	5.6e-04	-2.63	-5.9	2.9e-09	0.45	0.02	0.87	TRUE
5	GTEx	Brain Cerebellar Hemisphere	SLC25A1	0.34	0.19	enet	40	0.18	1.9e-05	-0.54	-5.8	6.7e-09	0.05	0.37	0.12	TRUE
7	GTEx	Brain Cerebellar Hemisphere	MRPL40	0.44	-0.01	enet	57	0.02	1.2e-01	-0.10	-5.5	2.9e-08	0.08	0.06	0.06	TRUE
25	GTEx	Thyroid	AC006547.15	0.15	0.05	enet	28	0.08	1.5e-06	-2.19	-5.5	2.9e-08	0.05	0.98	0.00	TRUE
12	GTEx	Colon Sigmoid	ARVCF	0.30	0.20	lasso	5	0.18	8.2e-07	-5.66	5.5	3.9e-08	-0.04	0.69	0.02	TRUE
10	GTEx	Brain Cerebellum	AC006547.8	0.25	0.03	lasso	4	0.06	7.3e-03	6.28	5.2	1.5e-07	-0.17	0.09	0.10	TRUE
3	GTEx	Artery Tibial	ARVCF	0.17	0.10	lasso	5	0.11	7.8e-09	12.22	-11.6	7.2e-31	0.01	1.00	0.00	FALSE
4	GTEx	Artery Tibial	AC006547.14	0.09	0.00	lasso	4	0.00	6.9e-01	12.15	-11.2	4.4e-29	-0.04	0.05	0.06	FALSE
18	GTEx	Nerve Tibial	ARVCF	0.19	0.09	lasso	6	0.13	2.3e-09	12.18	11.0	6.2e-28	-0.03	1.00	0.00	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	ARVCF	0.12	0.00	lasso	3	0.00	5.5e-01	11.41	10.6	1.8e-26	-0.02	0.20	0.04	FALSE
21	GTEx	Skin Sun Exposed Lower leg	ARVCF	0.09	0.00	lasso	3	0.00	3.8e-01	10.31	10.3	5.2e-25	-0.03	0.06	0.03	FALSE
14	GTEx	Esophagus Mucosa	ARVCF	0.21	0.02	enet	49	0.06	6.6e-05	12.22	10.0	1.4e-23	-0.06	0.96	0.00	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARVCF	0.03	0.01	blup	116	0.01	1.1e-02	-5.96	-8.4	3.5e-17	-0.03	0.02	0.27	FALSE
23	GTEx	Thyroid	ARVCF	0.25	0.09	enet	39	0.20	7.5e-15	12.18	8.2	2.5e-16	0.08	1.00	0.00	FALSE
8	GTEx	Brain Cerebellum	ARVCF	0.29	0.15	lasso	3	0.11	3.9e-04	-6.21	8.1	7.5e-16	-0.04	0.47	0.09	FALSE
15	GTEx	Esophagus Muscularis	ARVCF	0.23	0.17	lasso	6	0.14	3.9e-09	-5.66	7.6	3.0e-14	-0.04	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DGCR8	0.10	0.04	blup	444	0.05	3.3e-07	-0.68	6.6	4.4e-11	-0.03	0.96	0.00	FALSE
24	GTEx	Thyroid	TANGO2	0.17	0.04	enet	24	0.10	9.2e-08	-2.19	-6.3	3.7e-10	0.05	0.96	0.00	FALSE
6	GTEx	Brain Cerebellar Hemisphere	TANGO2	0.66	0.06	enet	52	0.38	1.1e-10	12.22	5.7	1.0e-08	0.01	0.12	0.08	FALSE
22	GTEx	Spleen	DGCR6	0.46	0.37	lasso	6	0.36	5.3e-10	-5.42	5.7	1.4e-08	0.02	0.01	0.99	FALSE
13	GTEx	Esophagus Mucosa	COMT	0.24	0.15	lasso	4	0.13	4.8e-09	-5.84	5.7	1.6e-08	-0.03	1.00	0.00	FALSE
11	GTEx	Cells Transformed fibroblasts	ZDHHC8	0.18	0.07	enet	26	0.14	8.9e-11	-2.63	-5.6	2.5e-08	-0.07	1.00	0.00	FALSE
17	GTEx	Lung	ARVCF	0.20	0.07	lasso	7	0.08	1.1e-06	-5.71	-5.2	1.7e-07	0.03	0.99	0.00	FALSE
26	METSIM	Adipose	DGCR14	0.11	0.05	bslmm	385	0.05	1.1e-07	-6.07	5.2	2.2e-07	0.07	0.01	0.99	FALSE
16	GTEx	Heart Atrial Appendage	DGCR6	0.61	0.34	lasso	10	0.35	1.3e-16	-5.42	5.2	2.7e-07	0.03	0.27	0.73	FALSE