Hub : Genes

DGCR8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0970 0.0270 6.6e-06 0.041 0.054 0.043 0.050 0.049 9.1e-06 3.3e-07 4.9e-06 9.1e-07 1.1e-06
2 YFS Blood 0.4511 0.0349 0.0e+00 0.139 0.317 0.323 0.321 0.282 3.8e-43 8.0e-107 5.8e-109 3.0e-108 6.4e-93
3 TCGA Brain Lower Grade Glioma 0.0406 0.0242 7.9e-03 0.006 0.014 0.002 NA 0.004 5.4e-02 8.3e-03 2.0e-01 NA 1.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.9 3.0 4.5 -1.0 -1.9 2.1
Bipolar Disorder or Schizophrenia 1.3 3.1 5.9 -1.7 0.6 2.4
Depressed Affect (Nagel 2018) 2.2 4.7 5.9 1.7 2.3 -2.4
Depression (Nagel 2018) 4.8 7.2 9.1 2.7 3.0 -2.3
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.2 1.1 0.1 0.2
Neuroticism (Nagel 2018) 2.6 6.2 12.0 1.2 2.2 -3.5
Schizophrenia (2018) 1.4 3.0 5.1 -1.3 2.3 1.5
Schizophrenia vs Biploar Disorder 1.2 1.6 1.7 -1.2 1.2 1.3
Worry (Nagel 2018) 1.4 3.0 4.3 -1.5 1.6 -2.1
Alzheimer’s Disease (in mother) 0.3 0.4 0.5 -0.5 0.5 -0.7
Alzheimer’s Disease (in father) 0.3 0.3 0.3 -0.6 -0.5 -0.5
Alzheimer’s Disease (including proxy) 0.7 1.0 1.8 -1.0 -0.3 -1.3
Crohns Disease (2017) 0.2 0.4 1.2 1.1 0.2 0.1
Irritable Bowel Disease (IBD) 0.1 0.3 0.7 0.9 -0.2 0.3
Ulcerative Colitis (UC) 0.1 0.3 0.7 0.2 -0.2 0.8
Major Depression (MDD) 1.2 1.4 4.3 0.0 0.0 -2.1
Reaction Time 1.2 2.3 4.9 -1.5 2.2 -0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.3 3.2 1.8 -0.5 0.6
Breast Cancer 0.6 1.4 3.0 0.6 0.9 -1.7
Ovarian Cancer 1.7 2.3 6.5 0.2 2.6 0.6
Prostate Cancer 2.7 3.8 9.4 0.5 3.1 1.3
Age at First Birth 1.5 2.2 6.5 -0.4 -2.6 -0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 2.4 -1.2 -1.5 -0.5
Coronary Artery Disease (CAD) 0.4 0.4 1.2 0.1 -0.4 1.1
Crohns Disease (2012) 0.3 0.5 1.3 0.5 0.3 1.2
Mean Putamen Volume 0.2 0.2 0.4 0.7 -0.2 0.3
Fasting Glucose 1.0 1.2 3.5 1.9 -0.0 -0.3
HbA1C 0.0 0.0 0.1 -0.0 0.3 0.1
HDL Cholesterol 0.6 1.0 1.7 -1.3 -1.1 -0.4
LDL Cholesterol 0.5 0.8 2.0 1.4 -0.4 -0.5
Lupus 0.7 1.0 2.7 -0.5 0.3 -1.6
Neuroticism (2016) 5.5 7.9 14.1 -0.1 3.1 -3.8
Primary Biliary Cirrhosis 1.4 1.9 5.6 -2.4 0.1 0.4
Rheumatoid Arthritis 0.3 0.5 1.3 0.3 -1.1 0.2
Schizophrenia (2014) 0.8 1.9 3.4 -0.6 1.4 1.8
Triglycerides 0.8 1.4 1.7 1.3 0.9 1.3
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.5 0.5 1.2 -0.2
Ulcerative Colitis 0.5 0.7 1.5 1.2 -0.1 0.7
Blood Eosinophil Count 0.4 3.1 8.6 2.9 -0.6 -0.6
Blood Platelet Count 1.3 15.1 43.4 6.6 -0.6 1.2
Blood Red Count 0.4 4.2 8.9 1.2 3.0 1.6
Blood White Count 1.3 9.8 17.0 4.1 0.2 3.5
Heel T-Score 0.2 1.8 3.9 0.6 2.0 1.1
BMI 0.4 2.2 3.8 0.8 -1.9 -1.5
Height 0.3 5.6 16.5 4.1 -0.0 0.5
Waist Hip Ratio (WHR) 0.4 1.9 3.5 -1.1 1.9 1.0
Systolic Blood Pressure 1.0 4.8 13.4 0.4 -3.7 -0.9
Smoking Status 0.2 0.5 0.6 0.7 0.7 -0.8
Allergy or Eczema 0.4 1.2 2.5 1.6 1.0 -0.3
Cardiovascular Disease 0.8 2.6 5.8 2.4 -0.8 -1.2
Hypothyroidism (self reported) 0.2 0.4 0.7 0.7 0.1 0.9
Respiratory disease 0.7 1.5 3.6 0.9 -0.4 1.9
Type 2 Diabetes (T2D) (2018) 1.5 2.8 5.0 2.2 1.5 -1.1
Lung FEV1/FVC ratio 0.5 2.5 6.8 -0.2 -0.9 -2.6
Lung FVC 0.3 1.6 3.9 -0.3 -0.8 -2.0
Neuroticism 3.2 7.8 15.5 1.1 2.6 -3.9
Chronotype (morning person) 0.2 0.4 0.6 -0.8 0.7 -0.4
Hair Pigment 0.1 3.0 7.5 -2.7 0.7 -1.0
Tanning 0.2 2.1 5.0 -0.8 -2.2 0.8
Hand grip strength (left) 0.3 0.8 1.5 1.2 -0.0 -0.9
Number of treatments/medications taken 1.1 2.1 3.9 1.4 -0.6 -2.0
Average weekly spirits intake 3.4 4.3 11.7 -1.0 -0.3 3.4
Sensitivity / hurt feelings 0.4 0.7 1.8 0.1 0.6 -1.3
Frequency of depressed mood in last 2 weeks 1.2 1.7 2.4 1.1 1.6 -1.2
Hearing difficulty/problems: Yes 0.0 0.1 0.1 0.2 0.3 0.3
Relative age of first facial hair 0.2 0.5 0.6 -0.7 -0.6 0.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.8 1.3 -0.2 0.8
Ever used hormone-replacement therapy (HRT) 4.2 5.3 10.6 1.5 3.3 -1.8
Ever had hysterectomy (womb removed) 2.1 2.4 5.7 2.4 1.2 -0.2
Systolic blood pressure, automated reading 1.4 4.1 12.0 -0.4 -3.5 0.0
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.2 0.5 0.9 -1.1
Angina 4.7 6.2 16.7 4.1 1.0 0.9
Medication for hormone replacement therapy 2.4 2.7 2.8 1.7 1.6 -1.6
Vitamin and mineral supplements 0.3 0.4 1.0 -0.1 -0.5 -1.0
Supplements: Zinc 0.3 0.3 0.6 -0.5 0.8 0.2
Medication: Co-codamol 1.9 2.2 4.1 1.6 2.0 0.2
Medication: Metformin 2.3 3.2 4.7 1.2 2.2 -1.9
Diabetes (father) 0.5 0.6 1.1 -1.0 0.9 0.1
Diabetes (mother) 1.7 2.2 3.5 1.9 1.7 -0.3
Severe depression (siblings) 0.5 0.6 1.3 -1.2 0.1 -0.6
Pack years adult smoking proportion 0.0 0.1 0.2 -0.4 -0.1 0.1
Impedance of leg (right) 0.4 1.9 5.0 -0.8 -0.4 2.2
Leg fat-free mass (left) 0.2 1.0 2.7 1.7 -0.4 -0.2
Trunk fat percentage 0.1 0.3 0.7 0.4 -0.8 -0.2
Hand grip strength (right) 0.2 0.6 1.4 1.2 -0.5 -0.3
Townsend deprivation index at recruitment 0.7 0.9 1.9 1.4 -0.7 0.5
Current tobacco smoking 0.1 0.1 0.2 0.5 0.1 0.2
Average weekly fortified wine intake 0.5 0.6 1.0 -1.0 -0.2 0.9
Maternal smoking around birth 1.1 1.7 4.7 2.2 -0.1 -0.5
Fed-up feelings 0.7 1.2 2.2 0.3 1.5 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.4 4.5 7.5 1.6 2.7 -1.9
Relative age voice broke 0.7 1.0 1.9 -1.4 -0.8 0.7
Taking other prescription medications 1.4 2.1 4.8 -0.1 -1.3 -2.2
Age when periods started (menarche) 0.3 0.8 1.4 -1.2 0.7 -0.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.6 -0.0 -0.4 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.7 1.3 -0.1 -0.2
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.1 -1.4 -0.3 0.6
Qualifications: CSEs or equivalent 2.9 3.9 6.3 2.3 2.5 -0.4
Serious illness, injury or assault to yourself 0.0 0.1 0.2 -0.0 -0.4 -0.0
High blood pressure 0.4 1.2 1.5 1.1 -1.0 -1.2
Hayfever, allergic rhinitis or eczema 0.4 1.0 2.0 1.4 0.9 0.1
Multivitamins +/- minerals 0.2 0.3 0.7 0.2 -0.5 0.8
Stomach or abdominal pain in last month 1.3 1.6 4.6 2.1 -0.1 0.3
Supplements: Glucosamine 1.0 1.3 2.4 0.3 1.2 -1.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.7 -0.2 -1.3 -0.2
Medication: Atenolol 0.1 0.1 0.3 0.6 0.2 -0.0
Medication: Levothyroxine sodium 0.7 1.2 2.7 1.6 0.6 0.8
Sitting height 0.3 2.3 4.9 2.2 -1.1 0.8
Chronic bronchitis/emphysema (father) 0.0 0.0 0.0 0.2 0.1 -0.0
High blood pressure (mother) 0.2 0.3 0.5 0.7 -0.2 -0.6
Body mass index (BMI) 0.2 1.0 2.0 0.8 -0.6 -1.4
Impedance of leg (left) 0.3 1.5 4.3 -0.4 -0.3 2.1
Leg predicted mass (left) 0.2 0.9 2.6 1.6 -0.4 -0.2
Trunk fat mass 0.2 0.7 1.3 1.1 -0.9 -0.3
Waist circumference 0.1 0.4 0.6 0.8 0.2 -0.6
Number of incorrect matches in round 3.3 5.4 12.4 -3.5 -1.9 0.3
Past tobacco smoking 1.8 3.2 7.6 -2.8 -1.4 -0.3
Alcohol usually taken with meals 0.2 0.4 0.9 -0.5 -0.0 1.0
Nervous feelings 1.0 1.8 2.9 -1.7 1.5 0.6
Frequency of tenseness / restlessness in last 2 weeks 2.6 4.0 7.9 1.3 1.5 -2.8
Hearing difficulty/problems with background noise 2.5 4.0 5.9 2.4 1.9 -1.6
Hair/balding pattern: Pattern 2 2.7 3.4 5.0 1.3 2.2 -1.9
Had menopause 2.9 3.6 6.0 -1.0 2.4 -1.9
Had other major operations 0.5 0.7 1.6 1.2 0.6 0.0
Forced vital capacity (FVC) 0.2 0.8 2.5 -0.2 -1.6 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 4.7 2.2 1.0 -0.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.6 0.0 0.8 -1.3
Qualifications: None of the above 0.2 0.4 0.6 -0.7 -0.1 -0.8
Financial difficulties in last 2 years 1.5 2.0 3.6 1.9 0.8 1.3
Mouth/teeth dental problems 1.0 1.5 2.2 -1.5 -1.5 0.5
Heart attack 0.4 0.6 1.5 1.2 -0.4 -0.2
Allergy 0.9 2.1 3.0 -1.7 -1.6 -0.9
Pain all over the body in last month 0.4 0.4 0.9 0.9 -0.1 -0.6
Diabetes (self-reported) 1.5 2.3 3.1 1.4 1.8 -1.3
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 2.8 1.7 -0.1 -0.4
Medication: Ramipril 0.4 0.5 0.7 0.7 -0.6 -0.8
Medication: Simvastatin 0.4 0.6 1.3 1.1 -0.6 -0.2
Fluid intelligence score 0.6 1.1 1.8 1.3 -1.3 0.1
Illnesses of siblings 0.7 0.9 2.2 -0.5 -0.5 1.5
Neuroticism score 1.0 2.1 5.7 0.3 0.8 -2.4
Weight 0.3 1.4 3.7 1.9 -0.7 -0.2
Impedance of arm (right) 0.4 2.0 3.6 -1.5 0.6 1.9
Arm fat percentage (right) 0.0 0.2 0.4 0.2 -0.3 -0.7
Trunk fat-free mass 0.6 3.2 9.3 3.1 -0.3 0.6
Hip circumference 0.3 1.4 3.0 1.7 -0.8 -0.7
Time employed in main current job 2.1 2.4 6.9 -0.3 -2.6 -0.4
Alcohol intake versus 10 years previously 0.3 0.4 0.8 0.9 -0.6 -0.1
Father’s age at death 0.6 0.8 1.5 -0.9 1.2 0.1
Worrier / anxious feelings 0.5 0.9 2.0 -0.8 0.1 -1.4
Frequency of tiredness / lethargy in last 2 weeks 2.5 4.1 8.7 3.0 1.9 0.1
Falls in the last year 5.6 7.6 14.9 3.9 2.7 0.9
Hair/balding pattern: Pattern 3 2.0 3.0 7.1 2.7 1.1 0.7
Number of live births 6.6 9.4 16.4 2.8 4.1 2.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.2 0.4 -1.5 -0.3
Pulse rate 1.7 2.9 6.0 -2.5 -1.4 -0.8
Happiness 0.6 0.7 2.0 1.4 0.2 -0.2
Noisy workplace 0.9 1.1 3.0 1.7 -0.3 -0.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.6 -0.8 -0.1 0.7
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 3.4 -1.3 -1.8 0.3
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 -0.6 -0.2 -0.3
Asthma 0.9 1.7 3.5 1.0 0.8 1.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.5 0.9 -0.5 -1.2
Medication: Cholesterol lowering 1.2 1.9 3.1 1.8 -1.4 -0.8
Depression (self-reported) 1.1 1.3 2.9 0.3 1.0 -1.7
Medication: Lansoprazole 1.5 1.7 4.7 2.2 0.6 0.3
Prospective memory result 0.5 0.7 1.4 0.7 1.2 -0.4
Lung cancer (father) 2.5 2.9 7.7 -0.8 -0.7 -2.8
Illnesses of mother 1.3 1.6 3.5 -0.5 -0.9 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.6 -0.1 -1.3 0.1
Pulse wave Arterial Stiffness index 1.6 1.8 3.1 1.1 1.8 1.1
Impedance of arm (left) 0.4 1.8 3.2 -1.8 0.5 1.4
Arm fat mass (right) 0.1 0.6 1.1 1.1 -0.6 -0.5
Trunk predicted mass 0.6 3.4 9.7 3.1 -0.3 0.6
Standing height 0.5 5.1 7.7 2.8 0.2 2.7
Length of working week for main job 0.5 0.6 1.1 0.6 -0.4 -1.1
Exposure to tobacco smoke at home 1.7 2.0 3.8 1.9 0.2 -1.4
Breastfed as a baby 1.3 1.6 3.5 1.0 1.9 -0.5
Tense / ‘highly strung’ 1.1 1.9 3.1 0.1 1.7 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.4 8.3 0.8 1.2 -2.9
Hair/balding pattern: Pattern 4 0.3 0.8 0.8 -0.9 -0.9 0.9
Birth weight of first child 0.4 0.7 1.0 -0.7 -1.0 0.8
Peak expiratory flow (PEF) 0.7 1.6 3.8 1.9 -0.9 0.4
Pulse wave reflection index 2.0 2.4 4.4 1.7 2.1 -0.1
Ever highly irritable/argumentative for 2 days 3.9 4.7 8.5 2.3 2.9 -0.7
Loud music exposure frequency 0.3 0.3 0.9 0.9 0.0 0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.6 -0.0 -0.8 -0.8
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.1 0.7 1.1 -0.2
Blood clot in the leg (DVT) 2.7 3.5 5.6 2.4 2.1 -0.6
Medication: Paracetamol 1.4 2.3 3.0 1.7 -1.3 -1.5
Headache pain in last month 1.4 2.4 4.6 1.2 1.0 2.1
Medication for cholesterol, blood pressure or diabetes 1.7 2.7 4.0 -1.6 1.2 2.0
Glaucoma (self-reported) 0.7 0.8 2.1 1.5 -0.1 -0.6
Gout (self-reported) 0.9 1.3 3.6 -0.4 -1.9 -0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.9 0.5 -0.2 1.0
Medication: Amlodipine 0.7 1.0 2.7 0.1 -0.6 -1.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.3 -1.2 -0.5 -0.3
Birth weight 0.8 1.8 3.1 -1.8 -1.2 -1.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 0.0 0.0 -0.8
High blood pressure (siblings) 0.7 1.0 2.8 0.4 0.0 -1.7
Forced vital capacity (FVC), Best measure 0.1 0.5 1.2 -0.2 -1.1 0.4
Body fat percentage 0.1 0.3 0.7 0.3 -0.9 -0.3
Leg fat percentage (right) 0.3 0.9 1.4 0.2 -1.1 -1.2
Arm fat-free mass (right) 0.5 2.8 8.3 2.9 -0.3 -0.1
Exposure to tobacco smoke outside home 3.1 4.1 11.3 3.4 0.9 0.1
Comparative body size at age 10 0.4 1.2 3.5 -0.1 -0.4 -1.9
Number of full brothers 1.5 1.9 3.5 0.4 1.9 1.4
Worry too long after embarrassment 1.7 2.9 4.0 1.9 -1.1 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.2 1.5 0.8 0.5
Wheeze or whistling in the chest in last year 0.4 0.6 1.1 0.9 -0.3 1.0
Number of children fathered 0.5 0.5 0.9 -0.2 -0.8 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.6 4.2 -2.0 1.8 -0.7
Age at first live birth 0.5 0.9 2.2 -1.5 -0.6 -0.2
Pulse wave peak to peak time 1.3 1.6 2.3 -0.8 -1.5 -1.4
Health satisfaction 0.3 0.3 0.5 0.5 -0.5 0.7
Shortness of breath walking on level ground 0.2 0.2 0.5 0.2 -0.3 -0.7
Qualifications: College or University degree 0.1 0.4 0.8 -0.5 -0.9 0.3
Eye problems/disorders: None of the above 0.3 0.3 0.6 -0.1 -0.8 0.6
Mouth/teeth dental problems: Loose teeth 2.4 2.8 4.6 -0.2 2.1 -1.9
Emphysema/chronic bronchitis 1.0 1.1 1.3 1.0 1.0 1.1
Medication for pain relief, constipation, heartburn 1.8 3.0 6.8 -2.6 -0.2 1.5
Neck or shoulder pain in last month 5.6 7.9 20.8 4.6 1.2 -1.2
Medication: Blood pressure 1.2 2.2 3.0 1.7 -1.2 -1.4
Angina (self-reported) 4.7 6.2 16.6 4.1 1.1 0.9
Migraine (self-reported) 0.9 1.1 2.5 1.6 -0.6 -0.6
Medication: Ibuprofen 0.8 1.0 2.6 0.4 -0.4 -1.6
Medication: Allopurinol 0.8 1.0 2.1 -0.2 -1.4 -1.0
Medication: Omeprazole 0.6 0.7 1.7 -0.1 1.3 -0.5
Medication: Seretide 50 evohaler 1.1 1.2 2.5 -1.6 -0.8 -0.7
Mean time to correctly identify matches 0.9 1.7 2.5 -1.2 1.6 -1.0
Heart disease (mother) 1.0 1.2 2.8 -0.3 -0.7 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.7 3.2 6.2 2.5 -1.0 -1.5
Whole body fat mass 0.1 0.6 0.9 0.9 -0.9 -0.3
Leg fat mass (right) 0.3 1.2 1.6 0.9 -1.3 -1.1
Arm predicted mass (right) 0.5 2.7 7.9 2.8 -0.4 0.0
Pulse rate, automated reading 1.3 4.2 5.2 -2.1 -2.3 1.8
Alcohol intake frequency. 1.0 2.4 3.7 1.9 1.0 1.6
Comparative height size at age 10 0.5 2.6 4.3 1.8 0.5 2.1
Number of full sisters 1.5 1.8 4.4 -1.0 0.3 2.1
Suffer from ‘nerves’ 0.8 1.3 1.6 -1.3 1.0 1.2
Overall health rating 1.3 2.8 7.4 2.7 0.7 0.8
Chest pain or discomfort 1.0 1.5 4.5 2.1 -0.2 0.0
Had major operations 0.4 0.5 1.1 -0.1 -0.6 1.0
Age at last live birth 0.3 0.4 0.9 -0.9 0.5 -0.2
Family relationship satisfaction 0.1 0.2 0.2 0.2 -0.4 0.5
Leg pain on walking 1.5 1.9 2.9 1.7 1.6 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.2 0.6 1.1 -0.2
Commuting to job workplace: Car/motor vehicle 2.1 2.4 5.9 1.1 0.4 -2.4
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 3.1 -0.9 -0.7 -1.8
Medication: Aspirin 0.9 1.1 3.3 1.8 0.1 0.4
Supplements: Vitamin C 0.2 0.2 0.3 -0.6 -0.2 0.5
Knee pain experienced in last month 2.0 3.1 5.7 2.4 1.6 -1.0
Hypertension (Self-reported) 0.4 1.2 2.2 1.5 -0.7 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.0 0.3 -0.3
Illnesses of father: Heart disease 1.0 1.4 2.5 1.1 -1.6 -0.6
Illnesses of siblings: Diabetes 0.1 0.2 0.2 -0.4 0.2 -0.5
Smoking status: Previous 1.0 1.4 2.4 1.4 1.5 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.2 0.6 -1.0 1.1
Whole body fat-free mass 0.4 2.4 6.9 2.6 -0.4 0.3
Leg fat-free mass (right) 0.2 1.3 3.8 2.0 -0.1 -0.2
Arm fat percentage (left) 0.1 0.4 1.0 0.0 -0.5 -1.0
Average weekly red wine intake 0.4 0.6 1.8 0.2 0.2 1.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.2 -1.0 0.3 -1.1
Mood swings 0.2 0.4 0.7 -0.2 0.6 -0.8
Loneliness, isolation 2.0 2.7 5.7 2.4 1.5 -0.5
Long-standing illness, disability or infirmity 1.5 2.3 6.3 2.5 -0.0 0.8
Ever had bowel cancer screening 1.9 2.2 5.9 -0.2 0.9 -2.4
Diabetes diagnosed by doctor 1.7 2.7 5.1 1.4 2.3 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.1 1.0 1.1 -1.5
Friendships satisfaction 0.1 0.1 0.3 0.5 0.3 -0.2
Qualifications: nursing, teaching 0.0 0.0 0.1 -0.2 0.1 0.2
Commuting to job workplace: Walk 1.3 1.4 3.8 0.5 0.1 2.0
Eye problems/disorders: Cataract 0.9 1.1 1.6 -0.3 1.3 -1.2
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 7.7 2.8 0.7 -1.1
Medication for cholesterol 1.7 2.6 4.9 -1.0 -2.2 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.2 -0.2 -0.5 -0.4
Back pain experienced in last month 5.3 7.8 18.3 4.3 1.9 -1.1
Mineral and other dietary supplements 0.5 0.7 1.0 1.0 0.4 1.0
Breast cancer (self-reported) 0.3 0.4 1.1 -0.1 -1.0 0.2
Asthma (self-reported) 0.8 1.5 3.0 1.0 0.7 1.7
Osteoporosis (self-reported) 0.1 0.1 0.1 0.2 -0.3 0.2
Osteoarthritis (self-reported) 0.3 0.3 0.7 0.2 0.9 -0.4
Medication: Aspirin 0.8 1.1 2.8 1.7 -0.2 0.7
Medication: Gliclazide 1.7 2.0 2.9 1.7 1.2 -1.3
Illnesses of father: None of the above (group 1) 0.0 0.0 0.0 -0.1 -0.0 0.1
Smoking status: Current 0.1 0.1 0.2 0.5 -0.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.7 5.8 -1.7 -2.4 -2.3
Whole body water mass 0.4 2.4 7.2 2.7 -0.3 0.1
Leg predicted mass (right) 0.2 1.3 3.7 1.9 -0.1 -0.2
Arm fat mass (left) 0.2 0.6 1.4 1.2 -0.3 -0.7
Number of self-reported non-cancer illnesses 1.0 1.7 3.6 1.9 -1.0 -0.8
Average weekly champagne plus white wine intake 4.3 5.8 8.3 -1.9 -2.9 -2.4
Miserableness 3.7 6.4 8.2 2.1 2.9 -2.6
Guilty feelings 2.6 3.9 11.2 0.2 0.6 -3.3
Wears glasses or contact lenses 1.3 1.5 3.5 -1.9 -0.4 -0.8
Ever taken oral contraceptive pill 0.1 0.1 0.2 0.1 -0.3 -0.4
Hearing aid user 0.9 1.0 1.1 1.1 -0.9 1.0
Mother’s age at death 0.4 0.5 1.1 1.0 0.6 0.2
Financial situation satisfaction 1.3 1.6 3.9 2.0 0.8 -0.5
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.6 0.3 0.8 -0.0
Commuting to job workplace: Public transport 0.9 1.1 1.6 -1.3 -0.3 1.3
Eye problems/disorders: Glaucoma 0.4 0.4 0.9 0.2 -0.9 -0.6
Medication: Blood pressure 0.4 0.7 1.6 1.3 0.7 -0.3
Pain type(s) experienced in last month: Hip pain 3.5 4.3 12.3 3.5 0.7 -0.5
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.7 0.9 0.7 0.2
High cholesterol (Self-reported) 0.6 1.0 1.8 1.4 -0.0 -1.1
Medication: Bendroflumethiazide 0.6 1.0 2.5 0.6 0.2 -1.6
Medication: Paracetamol 0.9 1.4 1.9 1.4 -0.9 -1.3
Medication: Lisinopril 0.9 1.2 3.0 -0.3 -1.7 -0.6
Medication: Atorvastatin 0.2 0.3 0.7 0.8 0.3 -0.3
Illnesses of father: High blood pressure 0.6 0.8 1.7 -0.7 -1.3 0.3
Alcohol drinker status: Never 0.2 0.3 0.6 -0.0 -0.4 -0.8
Ever smoked 3.4 5.9 12.1 3.5 2.0 1.2
Basal metabolic rate 0.4 2.2 6.4 2.5 -0.5 0.3
Leg fat percentage (left) 0.2 0.8 1.5 0.4 -0.8 -1.2
Arm fat-free mass (left) 0.7 3.6 10.6 3.3 -0.3 0.3
Number of operations (self-reported) 1.3 1.9 3.2 1.8 0.9 -1.3
Average weekly beer plus cider intake 0.5 0.8 1.5 0.8 1.2 0.1
Irritability 3.4 5.7 13.0 1.8 1.0 -3.6
Risk taking 0.6 0.9 1.4 1.2 1.1 0.3
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.6 -1.3 -0.5 0.7
Fractured/broken bones in last 5 years 0.3 0.4 0.5 -0.7 0.7 -0.4
Age started oral contraceptive pill 1.8 2.3 5.2 -1.2 0.2 -2.3
Diastolic blood pressure, automated reading 0.7 2.2 4.2 -1.4 -2.1 -0.7
Ever depressed for a whole week 0.5 0.6 0.7 0.8 0.8 -0.8
Unable to work because of sickness or disability 0.3 0.4 0.8 -0.1 0.6 0.9
Commuting to job workplace: Cycle 1.0 1.2 2.7 1.7 0.6 0.8
Myopia 1.1 1.5 2.1 -1.4 -0.7 1.4
Vascular/heart problems diagnosed by doctor 0.6 1.6 1.8 -1.2 1.3 1.2
Cholesterol lowering medication 0.4 0.6 1.6 0.1 1.3 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.1 0.5 -0.6
Pain experienced in last month 5.2 8.8 22.1 -4.7 -1.7 1.2
Supplements: Calcium 0.7 0.8 2.2 -1.5 0.2 -0.3
Basal cell carcinoma (self-reported) 0.8 0.9 2.2 1.5 0.1 0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.0 1.4 -0.5 0.1
Deep venous thrombosis (DVT) (self-reported) 2.3 2.9 5.0 2.2 1.9 -0.4
Heart disease (siblings) 1.5 1.9 2.6 1.4 1.1 -1.6
Alcohol drinker status: Previous 0.5 0.6 1.4 0.1 -1.2 0.6
Pack years of smoking 0.0 0.1 0.1 -0.2 -0.2 -0.3
Impedance of whole body 0.4 1.9 4.3 -1.1 0.3 2.1
Leg fat mass (left) 0.3 1.1 1.3 1.0 -1.0 -1.1
Arm predicted mass (left) 0.6 3.3 9.8 3.1 -0.1 0.3