Hub : Genes

DGCR8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0970	0.0270	6.6e-06	0.041	0.054	0.043	0.050	0.049	9.1e-06	3.3e-07	4.9e-06	9.1e-07	1.1e-06
2	YFS	Blood	0.4511	0.0349	0.0e+00	0.139	0.317	0.323	0.321	0.282	3.8e-43	8.0e-107	5.8e-109	3.0e-108	6.4e-93
3	TCGA	Brain Lower Grade Glioma	0.0406	0.0242	7.9e-03	0.006	0.014	0.002	NA	0.004	5.4e-02	8.3e-03	2.0e-01	NA	1.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.9	3.0	4.5	-1.0	-1.9	2.1
Bipolar Disorder or Schizophrenia	1.3	3.1	5.9	-1.7	0.6	2.4
Depressed Affect (Nagel 2018)	2.2	4.7	5.9	1.7	2.3	-2.4
Depression (Nagel 2018)	4.8	7.2	9.1	2.7	3.0	-2.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.2	1.1	0.1	0.2
Neuroticism (Nagel 2018)	2.6	6.2	12.0	1.2	2.2	-3.5
Schizophrenia (2018)	1.4	3.0	5.1	-1.3	2.3	1.5
Schizophrenia vs Biploar Disorder	1.2	1.6	1.7	-1.2	1.2	1.3
Worry (Nagel 2018)	1.4	3.0	4.3	-1.5	1.6	-2.1
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	-0.5	0.5	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.3	-0.6	-0.5	-0.5
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	-1.0	-0.3	-1.3
Crohns Disease (2017)	0.2	0.4	1.2	1.1	0.2	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	0.9	-0.2	0.3
Ulcerative Colitis (UC)	0.1	0.3	0.7	0.2	-0.2	0.8
Major Depression (MDD)	1.2	1.4	4.3	0.0	0.0	-2.1
Reaction Time	1.2	2.3	4.9	-1.5	2.2	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.2	1.8	-0.5	0.6
Breast Cancer	0.6	1.4	3.0	0.6	0.9	-1.7
Ovarian Cancer	1.7	2.3	6.5	0.2	2.6	0.6
Prostate Cancer	2.7	3.8	9.4	0.5	3.1	1.3
Age at First Birth	1.5	2.2	6.5	-0.4	-2.6	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.3	2.4	-1.2	-1.5	-0.5
Coronary Artery Disease (CAD)	0.4	0.4	1.2	0.1	-0.4	1.1
Crohns Disease (2012)	0.3	0.5	1.3	0.5	0.3	1.2
Mean Putamen Volume	0.2	0.2	0.4	0.7	-0.2	0.3
Fasting Glucose	1.0	1.2	3.5	1.9	-0.0	-0.3
HbA1C	0.0	0.0	0.1	-0.0	0.3	0.1
HDL Cholesterol	0.6	1.0	1.7	-1.3	-1.1	-0.4
LDL Cholesterol	0.5	0.8	2.0	1.4	-0.4	-0.5
Lupus	0.7	1.0	2.7	-0.5	0.3	-1.6
Neuroticism (2016)	5.5	7.9	14.1	-0.1	3.1	-3.8
Primary Biliary Cirrhosis	1.4	1.9	5.6	-2.4	0.1	0.4
Rheumatoid Arthritis	0.3	0.5	1.3	0.3	-1.1	0.2
Schizophrenia (2014)	0.8	1.9	3.4	-0.6	1.4	1.8
Triglycerides	0.8	1.4	1.7	1.3	0.9	1.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	0.5	1.2	-0.2
Ulcerative Colitis	0.5	0.7	1.5	1.2	-0.1	0.7
Blood Eosinophil Count	0.4	3.1	8.6	2.9	-0.6	-0.6
Blood Platelet Count	1.3	15.1	43.4	6.6	-0.6	1.2
Blood Red Count	0.4	4.2	8.9	1.2	3.0	1.6
Blood White Count	1.3	9.8	17.0	4.1	0.2	3.5
Heel T-Score	0.2	1.8	3.9	0.6	2.0	1.1
BMI	0.4	2.2	3.8	0.8	-1.9	-1.5
Height	0.3	5.6	16.5	4.1	-0.0	0.5
Waist Hip Ratio (WHR)	0.4	1.9	3.5	-1.1	1.9	1.0
Systolic Blood Pressure	1.0	4.8	13.4	0.4	-3.7	-0.9
Smoking Status	0.2	0.5	0.6	0.7	0.7	-0.8
Allergy or Eczema	0.4	1.2	2.5	1.6	1.0	-0.3
Cardiovascular Disease	0.8	2.6	5.8	2.4	-0.8	-1.2
Hypothyroidism (self reported)	0.2	0.4	0.7	0.7	0.1	0.9
Respiratory disease	0.7	1.5	3.6	0.9	-0.4	1.9
Type 2 Diabetes (T2D) (2018)	1.5	2.8	5.0	2.2	1.5	-1.1
Lung FEV1/FVC ratio	0.5	2.5	6.8	-0.2	-0.9	-2.6
Lung FVC	0.3	1.6	3.9	-0.3	-0.8	-2.0
Neuroticism	3.2	7.8	15.5	1.1	2.6	-3.9
Chronotype (morning person)	0.2	0.4	0.6	-0.8	0.7	-0.4
Hair Pigment	0.1	3.0	7.5	-2.7	0.7	-1.0
Tanning	0.2	2.1	5.0	-0.8	-2.2	0.8
Hand grip strength (left)	0.3	0.8	1.5	1.2	-0.0	-0.9
Number of treatments/medications taken	1.1	2.1	3.9	1.4	-0.6	-2.0
Average weekly spirits intake	3.4	4.3	11.7	-1.0	-0.3	3.4
Sensitivity / hurt feelings	0.4	0.7	1.8	0.1	0.6	-1.3
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.4	1.1	1.6	-1.2
Hearing difficulty/problems: Yes	0.0	0.1	0.1	0.2	0.3	0.3
Relative age of first facial hair	0.2	0.5	0.6	-0.7	-0.6	0.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.8	1.3	-0.2	0.8
Ever used hormone-replacement therapy (HRT)	4.2	5.3	10.6	1.5	3.3	-1.8
Ever had hysterectomy (womb removed)	2.1	2.4	5.7	2.4	1.2	-0.2
Systolic blood pressure, automated reading	1.4	4.1	12.0	-0.4	-3.5	0.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.2	0.5	0.9	-1.1
Angina	4.7	6.2	16.7	4.1	1.0	0.9
Medication for hormone replacement therapy	2.4	2.7	2.8	1.7	1.6	-1.6
Vitamin and mineral supplements	0.3	0.4	1.0	-0.1	-0.5	-1.0
Supplements: Zinc	0.3	0.3	0.6	-0.5	0.8	0.2
Medication: Co-codamol	1.9	2.2	4.1	1.6	2.0	0.2
Medication: Metformin	2.3	3.2	4.7	1.2	2.2	-1.9
Diabetes (father)	0.5	0.6	1.1	-1.0	0.9	0.1
Diabetes (mother)	1.7	2.2	3.5	1.9	1.7	-0.3
Severe depression (siblings)	0.5	0.6	1.3	-1.2	0.1	-0.6
Pack years adult smoking proportion	0.0	0.1	0.2	-0.4	-0.1	0.1
Impedance of leg (right)	0.4	1.9	5.0	-0.8	-0.4	2.2
Leg fat-free mass (left)	0.2	1.0	2.7	1.7	-0.4	-0.2
Trunk fat percentage	0.1	0.3	0.7	0.4	-0.8	-0.2
Hand grip strength (right)	0.2	0.6	1.4	1.2	-0.5	-0.3
Townsend deprivation index at recruitment	0.7	0.9	1.9	1.4	-0.7	0.5
Current tobacco smoking	0.1	0.1	0.2	0.5	0.1	0.2
Average weekly fortified wine intake	0.5	0.6	1.0	-1.0	-0.2	0.9
Maternal smoking around birth	1.1	1.7	4.7	2.2	-0.1	-0.5
Fed-up feelings	0.7	1.2	2.2	0.3	1.5	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	3.4	4.5	7.5	1.6	2.7	-1.9
Relative age voice broke	0.7	1.0	1.9	-1.4	-0.8	0.7
Taking other prescription medications	1.4	2.1	4.8	-0.1	-1.3	-2.2
Age when periods started (menarche)	0.3	0.8	1.4	-1.2	0.7	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	-0.0	-0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.7	1.3	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.1	-1.4	-0.3	0.6
Qualifications: CSEs or equivalent	2.9	3.9	6.3	2.3	2.5	-0.4
Serious illness, injury or assault to yourself	0.0	0.1	0.2	-0.0	-0.4	-0.0
High blood pressure	0.4	1.2	1.5	1.1	-1.0	-1.2
Hayfever, allergic rhinitis or eczema	0.4	1.0	2.0	1.4	0.9	0.1
Multivitamins +/- minerals	0.2	0.3	0.7	0.2	-0.5	0.8
Stomach or abdominal pain in last month	1.3	1.6	4.6	2.1	-0.1	0.3
Supplements: Glucosamine	1.0	1.3	2.4	0.3	1.2	-1.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.2	-1.3	-0.2
Medication: Atenolol	0.1	0.1	0.3	0.6	0.2	-0.0
Medication: Levothyroxine sodium	0.7	1.2	2.7	1.6	0.6	0.8
Sitting height	0.3	2.3	4.9	2.2	-1.1	0.8
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.2	0.1	-0.0
High blood pressure (mother)	0.2	0.3	0.5	0.7	-0.2	-0.6
Body mass index (BMI)	0.2	1.0	2.0	0.8	-0.6	-1.4
Impedance of leg (left)	0.3	1.5	4.3	-0.4	-0.3	2.1
Leg predicted mass (left)	0.2	0.9	2.6	1.6	-0.4	-0.2
Trunk fat mass	0.2	0.7	1.3	1.1	-0.9	-0.3
Waist circumference	0.1	0.4	0.6	0.8	0.2	-0.6
Number of incorrect matches in round	3.3	5.4	12.4	-3.5	-1.9	0.3
Past tobacco smoking	1.8	3.2	7.6	-2.8	-1.4	-0.3
Alcohol usually taken with meals	0.2	0.4	0.9	-0.5	-0.0	1.0
Nervous feelings	1.0	1.8	2.9	-1.7	1.5	0.6
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	7.9	1.3	1.5	-2.8
Hearing difficulty/problems with background noise	2.5	4.0	5.9	2.4	1.9	-1.6
Hair/balding pattern: Pattern 2	2.7	3.4	5.0	1.3	2.2	-1.9
Had menopause	2.9	3.6	6.0	-1.0	2.4	-1.9
Had other major operations	0.5	0.7	1.6	1.2	0.6	0.0
Forced vital capacity (FVC)	0.2	0.8	2.5	-0.2	-1.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.7	2.2	1.0	-0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	0.0	0.8	-1.3
Qualifications: None of the above	0.2	0.4	0.6	-0.7	-0.1	-0.8
Financial difficulties in last 2 years	1.5	2.0	3.6	1.9	0.8	1.3
Mouth/teeth dental problems	1.0	1.5	2.2	-1.5	-1.5	0.5
Heart attack	0.4	0.6	1.5	1.2	-0.4	-0.2
Allergy	0.9	2.1	3.0	-1.7	-1.6	-0.9
Pain all over the body in last month	0.4	0.4	0.9	0.9	-0.1	-0.6
Diabetes (self-reported)	1.5	2.3	3.1	1.4	1.8	-1.3
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.8	1.7	-0.1	-0.4
Medication: Ramipril	0.4	0.5	0.7	0.7	-0.6	-0.8
Medication: Simvastatin	0.4	0.6	1.3	1.1	-0.6	-0.2
Fluid intelligence score	0.6	1.1	1.8	1.3	-1.3	0.1
Illnesses of siblings	0.7	0.9	2.2	-0.5	-0.5	1.5
Neuroticism score	1.0	2.1	5.7	0.3	0.8	-2.4
Weight	0.3	1.4	3.7	1.9	-0.7	-0.2
Impedance of arm (right)	0.4	2.0	3.6	-1.5	0.6	1.9
Arm fat percentage (right)	0.0	0.2	0.4	0.2	-0.3	-0.7
Trunk fat-free mass	0.6	3.2	9.3	3.1	-0.3	0.6
Hip circumference	0.3	1.4	3.0	1.7	-0.8	-0.7
Time employed in main current job	2.1	2.4	6.9	-0.3	-2.6	-0.4
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.9	-0.6	-0.1
Father’s age at death	0.6	0.8	1.5	-0.9	1.2	0.1
Worrier / anxious feelings	0.5	0.9	2.0	-0.8	0.1	-1.4
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	8.7	3.0	1.9	0.1
Falls in the last year	5.6	7.6	14.9	3.9	2.7	0.9
Hair/balding pattern: Pattern 3	2.0	3.0	7.1	2.7	1.1	0.7
Number of live births	6.6	9.4	16.4	2.8	4.1	2.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.2	0.4	-1.5	-0.3
Pulse rate	1.7	2.9	6.0	-2.5	-1.4	-0.8
Happiness	0.6	0.7	2.0	1.4	0.2	-0.2
Noisy workplace	0.9	1.1	3.0	1.7	-0.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.6	-0.8	-0.1	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.4	-1.3	-1.8	0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	-0.6	-0.2	-0.3
Asthma	0.9	1.7	3.5	1.0	0.8	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	0.9	-0.5	-1.2
Medication: Cholesterol lowering	1.2	1.9	3.1	1.8	-1.4	-0.8
Depression (self-reported)	1.1	1.3	2.9	0.3	1.0	-1.7
Medication: Lansoprazole	1.5	1.7	4.7	2.2	0.6	0.3
Prospective memory result	0.5	0.7	1.4	0.7	1.2	-0.4
Lung cancer (father)	2.5	2.9	7.7	-0.8	-0.7	-2.8
Illnesses of mother	1.3	1.6	3.5	-0.5	-0.9	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.6	-0.1	-1.3	0.1
Pulse wave Arterial Stiffness index	1.6	1.8	3.1	1.1	1.8	1.1
Impedance of arm (left)	0.4	1.8	3.2	-1.8	0.5	1.4
Arm fat mass (right)	0.1	0.6	1.1	1.1	-0.6	-0.5
Trunk predicted mass	0.6	3.4	9.7	3.1	-0.3	0.6
Standing height	0.5	5.1	7.7	2.8	0.2	2.7
Length of working week for main job	0.5	0.6	1.1	0.6	-0.4	-1.1
Exposure to tobacco smoke at home	1.7	2.0	3.8	1.9	0.2	-1.4
Breastfed as a baby	1.3	1.6	3.5	1.0	1.9	-0.5
Tense / ‘highly strung’	1.1	1.9	3.1	0.1	1.7	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.4	8.3	0.8	1.2	-2.9
Hair/balding pattern: Pattern 4	0.3	0.8	0.8	-0.9	-0.9	0.9
Birth weight of first child	0.4	0.7	1.0	-0.7	-1.0	0.8
Peak expiratory flow (PEF)	0.7	1.6	3.8	1.9	-0.9	0.4
Pulse wave reflection index	2.0	2.4	4.4	1.7	2.1	-0.1
Ever highly irritable/argumentative for 2 days	3.9	4.7	8.5	2.3	2.9	-0.7
Loud music exposure frequency	0.3	0.3	0.9	0.9	0.0	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	-0.0	-0.8	-0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.1	0.7	1.1	-0.2
Blood clot in the leg (DVT)	2.7	3.5	5.6	2.4	2.1	-0.6
Medication: Paracetamol	1.4	2.3	3.0	1.7	-1.3	-1.5
Headache pain in last month	1.4	2.4	4.6	1.2	1.0	2.1
Medication for cholesterol, blood pressure or diabetes	1.7	2.7	4.0	-1.6	1.2	2.0
Glaucoma (self-reported)	0.7	0.8	2.1	1.5	-0.1	-0.6
Gout (self-reported)	0.9	1.3	3.6	-0.4	-1.9	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	0.5	-0.2	1.0
Medication: Amlodipine	0.7	1.0	2.7	0.1	-0.6	-1.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	-1.2	-0.5	-0.3
Birth weight	0.8	1.8	3.1	-1.8	-1.2	-1.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.0	0.0	-0.8
High blood pressure (siblings)	0.7	1.0	2.8	0.4	0.0	-1.7
Forced vital capacity (FVC), Best measure	0.1	0.5	1.2	-0.2	-1.1	0.4
Body fat percentage	0.1	0.3	0.7	0.3	-0.9	-0.3
Leg fat percentage (right)	0.3	0.9	1.4	0.2	-1.1	-1.2
Arm fat-free mass (right)	0.5	2.8	8.3	2.9	-0.3	-0.1
Exposure to tobacco smoke outside home	3.1	4.1	11.3	3.4	0.9	0.1
Comparative body size at age 10	0.4	1.2	3.5	-0.1	-0.4	-1.9
Number of full brothers	1.5	1.9	3.5	0.4	1.9	1.4
Worry too long after embarrassment	1.7	2.9	4.0	1.9	-1.1	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.2	1.5	0.8	0.5
Wheeze or whistling in the chest in last year	0.4	0.6	1.1	0.9	-0.3	1.0
Number of children fathered	0.5	0.5	0.9	-0.2	-0.8	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	4.2	-2.0	1.8	-0.7
Age at first live birth	0.5	0.9	2.2	-1.5	-0.6	-0.2
Pulse wave peak to peak time	1.3	1.6	2.3	-0.8	-1.5	-1.4
Health satisfaction	0.3	0.3	0.5	0.5	-0.5	0.7
Shortness of breath walking on level ground	0.2	0.2	0.5	0.2	-0.3	-0.7
Qualifications: College or University degree	0.1	0.4	0.8	-0.5	-0.9	0.3
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.1	-0.8	0.6
Mouth/teeth dental problems: Loose teeth	2.4	2.8	4.6	-0.2	2.1	-1.9
Emphysema/chronic bronchitis	1.0	1.1	1.3	1.0	1.0	1.1
Medication for pain relief, constipation, heartburn	1.8	3.0	6.8	-2.6	-0.2	1.5
Neck or shoulder pain in last month	5.6	7.9	20.8	4.6	1.2	-1.2
Medication: Blood pressure	1.2	2.2	3.0	1.7	-1.2	-1.4
Angina (self-reported)	4.7	6.2	16.6	4.1	1.1	0.9
Migraine (self-reported)	0.9	1.1	2.5	1.6	-0.6	-0.6
Medication: Ibuprofen	0.8	1.0	2.6	0.4	-0.4	-1.6
Medication: Allopurinol	0.8	1.0	2.1	-0.2	-1.4	-1.0
Medication: Omeprazole	0.6	0.7	1.7	-0.1	1.3	-0.5
Medication: Seretide 50 evohaler	1.1	1.2	2.5	-1.6	-0.8	-0.7
Mean time to correctly identify matches	0.9	1.7	2.5	-1.2	1.6	-1.0
Heart disease (mother)	1.0	1.2	2.8	-0.3	-0.7	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.7	3.2	6.2	2.5	-1.0	-1.5
Whole body fat mass	0.1	0.6	0.9	0.9	-0.9	-0.3
Leg fat mass (right)	0.3	1.2	1.6	0.9	-1.3	-1.1
Arm predicted mass (right)	0.5	2.7	7.9	2.8	-0.4	0.0
Pulse rate, automated reading	1.3	4.2	5.2	-2.1	-2.3	1.8
Alcohol intake frequency.	1.0	2.4	3.7	1.9	1.0	1.6
Comparative height size at age 10	0.5	2.6	4.3	1.8	0.5	2.1
Number of full sisters	1.5	1.8	4.4	-1.0	0.3	2.1
Suffer from ‘nerves’	0.8	1.3	1.6	-1.3	1.0	1.2
Overall health rating	1.3	2.8	7.4	2.7	0.7	0.8
Chest pain or discomfort	1.0	1.5	4.5	2.1	-0.2	0.0
Had major operations	0.4	0.5	1.1	-0.1	-0.6	1.0
Age at last live birth	0.3	0.4	0.9	-0.9	0.5	-0.2
Family relationship satisfaction	0.1	0.2	0.2	0.2	-0.4	0.5
Leg pain on walking	1.5	1.9	2.9	1.7	1.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	0.6	1.1	-0.2
Commuting to job workplace: Car/motor vehicle	2.1	2.4	5.9	1.1	0.4	-2.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.1	-0.9	-0.7	-1.8
Medication: Aspirin	0.9	1.1	3.3	1.8	0.1	0.4
Supplements: Vitamin C	0.2	0.2	0.3	-0.6	-0.2	0.5
Knee pain experienced in last month	2.0	3.1	5.7	2.4	1.6	-1.0
Hypertension (Self-reported)	0.4	1.2	2.2	1.5	-0.7	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.0	0.3	-0.3
Illnesses of father: Heart disease	1.0	1.4	2.5	1.1	-1.6	-0.6
Illnesses of siblings: Diabetes	0.1	0.2	0.2	-0.4	0.2	-0.5
Smoking status: Previous	1.0	1.4	2.4	1.4	1.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	0.6	-1.0	1.1
Whole body fat-free mass	0.4	2.4	6.9	2.6	-0.4	0.3
Leg fat-free mass (right)	0.2	1.3	3.8	2.0	-0.1	-0.2
Arm fat percentage (left)	0.1	0.4	1.0	0.0	-0.5	-1.0
Average weekly red wine intake	0.4	0.6	1.8	0.2	0.2	1.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.2	-1.0	0.3	-1.1
Mood swings	0.2	0.4	0.7	-0.2	0.6	-0.8
Loneliness, isolation	2.0	2.7	5.7	2.4	1.5	-0.5
Long-standing illness, disability or infirmity	1.5	2.3	6.3	2.5	-0.0	0.8
Ever had bowel cancer screening	1.9	2.2	5.9	-0.2	0.9	-2.4
Diabetes diagnosed by doctor	1.7	2.7	5.1	1.4	2.3	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.1	1.0	1.1	-1.5
Friendships satisfaction	0.1	0.1	0.3	0.5	0.3	-0.2
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.2	0.1	0.2
Commuting to job workplace: Walk	1.3	1.4	3.8	0.5	0.1	2.0
Eye problems/disorders: Cataract	0.9	1.1	1.6	-0.3	1.3	-1.2
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	7.7	2.8	0.7	-1.1
Medication for cholesterol	1.7	2.6	4.9	-1.0	-2.2	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	-0.2	-0.5	-0.4
Back pain experienced in last month	5.3	7.8	18.3	4.3	1.9	-1.1
Mineral and other dietary supplements	0.5	0.7	1.0	1.0	0.4	1.0
Breast cancer (self-reported)	0.3	0.4	1.1	-0.1	-1.0	0.2
Asthma (self-reported)	0.8	1.5	3.0	1.0	0.7	1.7
Osteoporosis (self-reported)	0.1	0.1	0.1	0.2	-0.3	0.2
Osteoarthritis (self-reported)	0.3	0.3	0.7	0.2	0.9	-0.4
Medication: Aspirin	0.8	1.1	2.8	1.7	-0.2	0.7
Medication: Gliclazide	1.7	2.0	2.9	1.7	1.2	-1.3
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.1	-0.0	0.1
Smoking status: Current	0.1	0.1	0.2	0.5	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	5.8	-1.7	-2.4	-2.3
Whole body water mass	0.4	2.4	7.2	2.7	-0.3	0.1
Leg predicted mass (right)	0.2	1.3	3.7	1.9	-0.1	-0.2
Arm fat mass (left)	0.2	0.6	1.4	1.2	-0.3	-0.7
Number of self-reported non-cancer illnesses	1.0	1.7	3.6	1.9	-1.0	-0.8
Average weekly champagne plus white wine intake	4.3	5.8	8.3	-1.9	-2.9	-2.4
Miserableness	3.7	6.4	8.2	2.1	2.9	-2.6
Guilty feelings	2.6	3.9	11.2	0.2	0.6	-3.3
Wears glasses or contact lenses	1.3	1.5	3.5	-1.9	-0.4	-0.8
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.1	-0.3	-0.4
Hearing aid user	0.9	1.0	1.1	1.1	-0.9	1.0
Mother’s age at death	0.4	0.5	1.1	1.0	0.6	0.2
Financial situation satisfaction	1.3	1.6	3.9	2.0	0.8	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	0.3	0.8	-0.0
Commuting to job workplace: Public transport	0.9	1.1	1.6	-1.3	-0.3	1.3
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	0.2	-0.9	-0.6
Medication: Blood pressure	0.4	0.7	1.6	1.3	0.7	-0.3
Pain type(s) experienced in last month: Hip pain	3.5	4.3	12.3	3.5	0.7	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.9	0.7	0.2
High cholesterol (Self-reported)	0.6	1.0	1.8	1.4	-0.0	-1.1
Medication: Bendroflumethiazide	0.6	1.0	2.5	0.6	0.2	-1.6
Medication: Paracetamol	0.9	1.4	1.9	1.4	-0.9	-1.3
Medication: Lisinopril	0.9	1.2	3.0	-0.3	-1.7	-0.6
Medication: Atorvastatin	0.2	0.3	0.7	0.8	0.3	-0.3
Illnesses of father: High blood pressure	0.6	0.8	1.7	-0.7	-1.3	0.3
Alcohol drinker status: Never	0.2	0.3	0.6	-0.0	-0.4	-0.8
Ever smoked	3.4	5.9	12.1	3.5	2.0	1.2
Basal metabolic rate	0.4	2.2	6.4	2.5	-0.5	0.3
Leg fat percentage (left)	0.2	0.8	1.5	0.4	-0.8	-1.2
Arm fat-free mass (left)	0.7	3.6	10.6	3.3	-0.3	0.3
Number of operations (self-reported)	1.3	1.9	3.2	1.8	0.9	-1.3
Average weekly beer plus cider intake	0.5	0.8	1.5	0.8	1.2	0.1
Irritability	3.4	5.7	13.0	1.8	1.0	-3.6
Risk taking	0.6	0.9	1.4	1.2	1.1	0.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.6	-1.3	-0.5	0.7
Fractured/broken bones in last 5 years	0.3	0.4	0.5	-0.7	0.7	-0.4
Age started oral contraceptive pill	1.8	2.3	5.2	-1.2	0.2	-2.3
Diastolic blood pressure, automated reading	0.7	2.2	4.2	-1.4	-2.1	-0.7
Ever depressed for a whole week	0.5	0.6	0.7	0.8	0.8	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.1	0.6	0.9
Commuting to job workplace: Cycle	1.0	1.2	2.7	1.7	0.6	0.8
Myopia	1.1	1.5	2.1	-1.4	-0.7	1.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	1.8	-1.2	1.3	1.2
Cholesterol lowering medication	0.4	0.6	1.6	0.1	1.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.1	0.5	-0.6
Pain experienced in last month	5.2	8.8	22.1	-4.7	-1.7	1.2
Supplements: Calcium	0.7	0.8	2.2	-1.5	0.2	-0.3
Basal cell carcinoma (self-reported)	0.8	0.9	2.2	1.5	0.1	0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	1.4	-0.5	0.1
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	5.0	2.2	1.9	-0.4
Heart disease (siblings)	1.5	1.9	2.6	1.4	1.1	-1.6
Alcohol drinker status: Previous	0.5	0.6	1.4	0.1	-1.2	0.6
Pack years of smoking	0.0	0.1	0.1	-0.2	-0.2	-0.3
Impedance of whole body	0.4	1.9	4.3	-1.1	0.3	2.1
Leg fat mass (left)	0.3	1.1	1.3	1.0	-1.0	-1.1
Arm predicted mass (left)	0.6	3.3	9.8	3.1	-0.1	0.3