Hub : Genes

DGCR14

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0960	0.0330	4.7e-05	0.062	0.021	0.057	0.042	0.068	4.8e-08	1.3e-03	1.5e-07	6.6e-06	1.1e-08
2	GTEx	Testis	0.2150	0.0660	1.9e-05	0.081	NA	0.134	NA	0.142	1.8e-04	NA	1.6e-06	NA	7.5e-07
3	METSIM	Adipose	0.1081	0.0415	2.7e-03	0.048	0.008	0.034	0.047	0.038	8.4e-08	1.9e-02	6.4e-06	1.1e-07	1.8e-06
4	YFS	Blood	0.2824	0.0461	0.0e+00	0.096	0.094	0.123	0.125	0.127	1.4e-29	5.1e-29	5.7e-38	1.4e-38	3.4e-39
5	TCGA	Breast Invasive Carcinoma	0.0287	0.0182	6.9e-04	0.002	0.011	0.007	NA	0.008	9.7e-02	1.9e-03	1.4e-02	NA	8.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	2.1	-0.4	-0.1	-0.2	-1.5	0.8
Bipolar Disorder or Schizophrenia	0.8	2.0	3.3	-1.1	1.8	-0.4	-1.4	1.8
Depressed Affect (Nagel 2018)	0.5	1.1	2.6	1.0	0.1	1.6	1.4	-0.0
Depression (Nagel 2018)	0.6	1.0	2.8	-0.2	-0.4	1.7	1.3	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.8	0.9	-0.7	0.7	0.3	-0.9
Neuroticism (Nagel 2018)	0.2	0.4	0.7	0.5	0.7	0.9	0.6	-0.4
Schizophrenia (2018)	1.0	2.0	5.6	-1.0	2.4	-0.4	-0.5	1.7
Schizophrenia vs Biploar Disorder	1.2	1.6	4.9	-1.2	2.2	-0.1	0.7	1.1
Worry (Nagel 2018)	0.7	1.6	2.8	1.0	0.0	1.7	1.4	-1.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.3	-0.5	0.1	0.8	1.1	-0.5
Alzheimer’s Disease (in father)	0.4	0.4	0.9	0.9	-0.2	0.3	0.1	-1.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.7	0.1	0.6	1.3	1.0	-0.5
Crohns Disease (2017)	0.4	1.0	2.7	1.0	-0.2	-1.0	-1.7	-0.2
Irritable Bowel Disease (IBD)	0.4	1.1	3.1	0.4	0.2	-1.4	-1.8	0.2
Ulcerative Colitis (UC)	0.4	0.8	1.3	-0.8	0.7	-1.0	-1.1	0.8
Major Depression (MDD)	0.4	0.5	1.8	0.0	0.6	1.3	0.5	0.1
Reaction Time	0.6	1.1	2.6	-0.7	1.4	0.8	-0.1	1.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.2	1.0	-0.7	0.0	-0.2	-1.5
Breast Cancer	1.3	3.2	8.0	1.3	-2.4	0.1	0.7	-2.8
Ovarian Cancer	1.0	1.3	2.4	0.7	-1.4	0.5	1.1	-1.6
Prostate Cancer	1.2	1.6	4.2	1.3	-0.0	1.5	2.1	0.3
Age at First Birth	0.7	1.1	2.2	-0.5	-1.1	1.3	1.5	-0.2
Bipolar Disorder (2011)	0.1	0.1	0.4	0.0	0.1	0.6	-0.1	0.2
Body Mass Index (BMI) (2010)	0.7	1.0	2.9	-0.5	1.1	-0.0	-0.8	1.7
Coronary Artery Disease (CAD)	0.5	0.6	1.5	0.0	-1.1	0.5	0.1	-1.2
Crohns Disease (2012)	1.1	1.8	4.8	0.3	0.4	-2.0	-2.2	0.3
Mean Putamen Volume	0.9	1.1	2.3	1.5	-0.6	0.5	1.0	-1.2
Fasting Glucose	0.3	0.3	0.6	0.5	0.5	-0.6	-0.4	0.7
HbA1C	0.6	0.7	1.5	0.1	0.9	-0.6	-1.2	0.9
HDL Cholesterol	0.8	1.3	3.3	1.4	-0.9	-0.0	0.9	-1.8
LDL Cholesterol	0.1	0.1	0.4	0.2	0.2	-0.5	-0.1	0.6
Lupus	1.6	2.4	8.8	-3.0	0.3	-1.3	-1.0	0.9
Neuroticism (2016)	0.6	0.9	3.0	-0.9	1.7	0.2	-0.4	0.5
Primary Biliary Cirrhosis	0.6	0.9	1.3	0.2	1.1	-0.9	-1.1	1.1
Rheumatoid Arthritis	0.4	0.6	1.5	-0.5	1.0	0.0	-0.2	1.2
Schizophrenia (2014)	0.8	1.8	5.0	-1.1	2.2	0.1	-0.2	1.6
Triglycerides	0.6	0.9	2.6	-0.8	1.1	0.2	0.3	1.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	0.0	0.3	-0.2	-1.3	1.4
Ulcerative Colitis	1.4	2.0	3.8	0.0	1.7	-1.3	-1.3	2.0
Blood Eosinophil Count	0.2	1.2	1.7	1.3	-0.9	1.0	1.3	-0.9
Blood Platelet Count	1.2	14.1	39.3	0.0	-2.0	5.2	6.3	-0.2
Blood Red Count	0.0	0.3	1.2	-1.1	0.5	-0.0	0.3	0.4
Blood White Count	1.1	8.0	20.9	-1.5	0.3	4.6	4.0	0.8
Heel T-Score	0.5	4.4	11.4	-1.7	-1.7	2.1	3.4	-0.4
BMI	0.1	0.7	2.0	-0.6	0.6	-1.4	-0.9	0.3
Height	0.1	2.0	9.4	-3.1	-0.1	0.4	0.5	0.2
Waist Hip Ratio (WHR)	1.7	7.8	14.0	-3.7	2.9	1.5	-0.2	3.7
Systolic Blood Pressure	0.2	0.8	1.6	1.2	1.3	0.0	-0.9	0.4
Smoking Status	0.4	1.0	2.5	-1.6	0.5	0.3	0.2	1.5
Allergy or Eczema	0.3	0.8	2.7	-0.3	-1.6	0.2	0.6	-0.8
Cardiovascular Disease	0.1	0.4	0.9	-0.5	0.9	0.3	-0.5	0.6
Hypothyroidism (self reported)	0.4	0.8	1.9	-1.4	1.0	-0.1	0.1	1.0
Respiratory disease	0.2	0.5	1.5	-1.2	0.1	0.4	0.6	0.8
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.8	1.3	-0.8	0.8	0.7	-1.1
Lung FEV1/FVC ratio	0.4	2.1	4.6	-0.6	2.1	1.2	-0.5	2.0
Lung FVC	0.1	0.5	1.4	-0.7	-1.2	-0.2	0.5	0.3
Neuroticism	0.8	2.0	5.3	0.6	1.1	2.3	1.7	0.2
Chronotype (morning person)	0.4	1.0	2.0	-0.6	-1.4	-1.3	-0.3	-0.9
Hair Pigment	0.1	2.5	5.2	2.3	-1.5	0.3	0.7	-2.1
Tanning	0.2	2.0	8.0	-0.3	-2.8	0.1	0.3	-1.3
Hand grip strength (left)	0.2	0.4	1.1	0.2	-1.0	-1.0	-0.2	-0.2
Number of treatments/medications taken	0.1	0.2	0.7	-0.1	0.3	0.8	0.5	-0.1
Average weekly spirits intake	2.7	3.4	8.1	-0.9	2.9	-0.6	-1.0	2.6
Sensitivity / hurt feelings	0.7	1.2	4.0	0.2	2.0	-0.2	-1.4	0.4
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.2	-1.0	-0.5	1.8	1.8	-0.3
Hearing difficulty/problems: Yes	1.7	2.6	4.2	1.2	-1.6	-2.1	-1.8	-1.2
Relative age of first facial hair	0.1	0.3	0.5	-0.5	0.7	-0.3	0.6	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.4	-0.2	1.2	-0.1	-1.1	0.4
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.7	1.2	-1.3	-1.3	0.1	-0.7
Ever had hysterectomy (womb removed)	1.0	1.1	2.7	0.9	-1.7	-0.7	0.6	-1.0
Systolic blood pressure, automated reading	0.5	1.3	2.0	1.4	1.4	0.3	-0.9	1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.6	1.3	0.1	0.2	0.5	-0.1
Angina	0.4	0.5	0.9	1.0	0.1	0.7	0.9	0.7
Medication for hormone replacement therapy	1.3	1.5	2.8	-1.4	-1.7	-1.5	0.0	-0.5
Vitamin and mineral supplements	0.4	0.5	1.8	1.3	0.0	0.5	0.7	-0.3
Supplements: Zinc	1.1	1.2	3.0	-1.7	-1.6	-0.0	0.4	0.4
Medication: Co-codamol	2.1	2.4	4.6	0.1	2.1	-1.4	-2.1	1.0
Medication: Metformin	0.1	0.2	0.6	0.8	0.2	0.5	-0.0	-0.2
Diabetes (father)	2.1	2.6	3.6	-1.9	1.8	-1.1	-1.3	1.9
Diabetes (mother)	0.8	1.0	2.2	-0.4	1.3	-0.8	-0.6	1.5
Severe depression (siblings)	0.2	0.2	0.6	-0.8	0.3	0.4	0.1	-0.0
Pack years adult smoking proportion	2.3	3.6	9.9	-0.9	2.2	-0.2	-1.4	3.1
Impedance of leg (right)	0.4	1.9	6.6	0.6	0.5	2.6	1.5	-0.5
Leg fat-free mass (left)	0.3	1.8	5.6	-2.4	-0.2	-1.5	-0.8	0.4
Trunk fat percentage	0.1	0.5	1.3	-0.2	1.2	-0.2	-0.6	0.9
Hand grip strength (right)	0.1	0.2	0.4	-0.5	-0.4	-0.1	0.6	0.5
Townsend deprivation index at recruitment	2.7	3.8	6.2	-0.8	2.5	-1.3	-2.3	2.2
Current tobacco smoking	0.7	1.1	2.6	-0.2	0.7	-1.3	-1.6	0.9
Average weekly fortified wine intake	0.6	0.7	1.9	0.1	-1.4	0.4	1.0	-0.6
Maternal smoking around birth	0.2	0.3	0.6	-0.2	-0.6	0.8	0.6	-0.5
Fed-up feelings	0.3	0.5	1.1	0.2	1.0	0.9	0.6	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.5	-0.1	0.8	1.6	0.7	0.4
Relative age voice broke	0.4	0.6	2.3	1.5	0.5	-0.3	-0.1	-0.8
Taking other prescription medications	0.5	0.8	2.5	-0.7	0.3	1.6	0.8	0.5
Age when periods started (menarche)	0.2	0.4	1.1	-0.2	0.7	0.6	1.1	-0.4
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.5	1.1	-1.3	-0.3	0.4	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	10.0	-0.7	-1.0	2.8	3.2	-0.0
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.0	1.4	-1.4	-0.1	0.4	-2.0
Qualifications: CSEs or equivalent	0.6	0.8	2.2	-0.1	-0.3	1.5	1.0	0.7
Serious illness, injury or assault to yourself	1.4	1.8	4.1	-0.2	1.7	-0.3	-1.4	2.0
High blood pressure	0.1	0.2	0.6	0.8	-0.0	0.3	-0.4	0.3
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.4	0.6	-2.3	0.4	0.6	-1.8
Multivitamins +/- minerals	0.5	0.6	1.2	-0.1	-1.1	-0.5	-0.5	-1.1
Stomach or abdominal pain in last month	0.5	0.6	1.5	0.4	-0.4	1.2	1.2	-0.3
Supplements: Glucosamine	1.2	1.5	3.3	0.8	-1.8	0.1	0.9	-1.7
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.8	0.2	2.2	1.4	0.7	2.0
Medication: Atenolol	0.3	0.4	0.9	-0.5	0.2	-0.6	-0.5	0.9
Medication: Levothyroxine sodium	0.2	0.3	1.0	0.1	0.5	0.4	1.0	0.2
Sitting height	0.1	1.0	1.9	0.6	-0.9	-1.3	-0.6	-1.4
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	-0.9	0.6	0.4	0.1	1.1
High blood pressure (mother)	0.7	1.0	2.1	1.2	-0.7	1.4	0.9	-0.5
Body mass index (BMI)	0.2	1.0	2.1	-0.5	0.4	-1.4	-1.2	0.9
Impedance of leg (left)	0.4	1.9	5.7	0.9	0.7	2.4	1.3	-0.8
Leg predicted mass (left)	0.4	1.9	5.8	-2.4	-0.3	-1.6	-0.9	0.3
Trunk fat mass	0.2	0.7	0.9	-0.9	0.9	-0.6	-0.8	0.8
Waist circumference	0.7	2.4	4.3	-2.1	1.4	-0.9	-1.4	1.7
Number of incorrect matches in round	0.2	0.4	1.1	-1.0	0.6	0.6	0.2	0.5
Past tobacco smoking	1.2	2.3	4.9	1.7	-1.8	-0.3	-0.3	-2.2
Alcohol usually taken with meals	0.1	0.2	0.3	0.5	0.1	0.3	0.3	-0.5
Nervous feelings	0.8	1.5	2.7	1.0	-1.1	1.1	1.1	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	-0.8	0.4	0.8	1.2	0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.7	0.8	-0.7	0.5	-0.4	-0.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.8	1.3	0.1	0.1	0.7	0.3
Had menopause	1.8	2.3	6.6	2.6	-1.0	-1.6	-1.2	-0.3
Had other major operations	1.1	1.3	2.2	1.5	-1.4	0.7	0.4	-1.3
Forced vital capacity (FVC)	0.3	1.1	2.6	-1.6	-1.3	0.2	1.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.0	-1.1	-0.7	2.0	2.2	-0.1
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	5.3	-2.3	-0.9	-1.1	-0.6	0.0
Qualifications: None of the above	1.5	3.2	7.3	0.2	2.7	-1.3	-1.9	1.9
Financial difficulties in last 2 years	0.1	0.2	0.5	-0.5	-0.0	-0.1	-0.4	-0.7
Mouth/teeth dental problems	0.5	0.8	2.1	0.2	-0.5	1.1	1.4	-0.7
Heart attack	0.6	0.7	2.4	-0.6	0.8	-0.2	-0.2	1.5
Allergy	0.1	0.3	0.6	0.4	0.8	-0.3	-0.4	0.6
Pain all over the body in last month	1.9	2.1	4.0	-1.4	1.9	-0.1	-0.9	2.0
Diabetes (self-reported)	0.1	0.1	0.3	-0.3	0.1	-0.1	-0.6	0.3
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	6.4	1.5	-1.2	1.5	2.5	-1.8
Medication: Ramipril	2.0	2.6	5.3	2.3	-0.5	1.8	1.7	-1.1
Medication: Simvastatin	0.5	0.7	2.3	-0.1	1.1	0.4	0.1	1.5
Fluid intelligence score	0.2	0.3	0.9	0.7	0.2	0.9	-0.0	-0.5
Illnesses of siblings	0.3	0.4	0.8	-0.7	0.3	0.4	0.9	-0.7
Neuroticism score	0.6	1.2	3.6	0.3	0.1	1.9	1.4	-0.6
Weight	0.3	1.6	2.7	-1.7	0.4	-1.6	-1.3	0.7
Impedance of arm (right)	0.2	1.0	3.6	0.2	1.9	1.2	0.2	0.4
Arm fat percentage (right)	0.2	0.9	1.6	-0.4	1.3	-0.6	-0.9	1.2
Trunk fat-free mass	0.4	2.1	6.4	-2.5	-0.5	-1.7	-0.9	0.2
Hip circumference	0.3	1.3	3.4	-0.1	0.2	-1.8	-1.9	0.1
Time employed in main current job	0.2	0.2	0.3	0.5	-0.0	-0.5	-0.6	0.2
Alcohol intake versus 10 years previously	0.9	1.3	3.1	1.1	-1.8	0.3	0.7	-1.3
Father’s age at death	0.5	0.6	2.0	-0.4	-0.8	0.1	0.6	-1.4
Worrier / anxious feelings	1.1	2.2	5.4	0.8	-1.8	0.8	1.0	-2.3
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.6	0.2	2.1	1.9	0.8	1.2
Falls in the last year	0.6	0.8	1.8	-1.3	1.0	-0.4	-0.8	0.7
Hair/balding pattern: Pattern 3	1.2	1.8	4.9	0.1	-0.9	-2.2	-1.9	-0.0
Number of live births	0.5	0.7	2.3	0.4	0.7	-0.2	-0.7	1.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.4	-1.6	-0.4	0.6	1.0	0.1
Pulse rate	0.5	0.8	1.5	-1.2	-0.0	-0.3	-1.0	1.1
Happiness	1.7	2.1	7.2	-0.1	-2.7	-0.2	0.6	-1.7
Noisy workplace	1.7	2.1	4.1	-1.2	-0.1	-2.0	-1.7	1.4
Qualifications: A levels/AS levels or equivalent	2.0	4.4	7.1	1.6	-2.4	1.3	2.7	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.5	1.2	0.5	-0.1	0.2	-0.6
Mouth/teeth dental problems: Dentures	1.1	1.9	3.5	-0.4	0.5	-1.8	-1.9	1.5
Asthma	0.7	1.3	3.9	-0.7	0.2	1.5	2.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.9	-0.3	2.0	0.3	0.1	0.7
Medication: Cholesterol lowering	0.4	0.6	1.6	-0.7	0.8	0.3	-0.0	1.3
Depression (self-reported)	0.4	0.5	1.0	0.4	0.8	1.0	0.6	0.6
Medication: Lansoprazole	1.0	1.1	2.4	0.0	-1.5	0.5	1.4	-1.0
Prospective memory result	0.3	0.4	1.2	0.5	-0.7	-0.2	0.1	-1.1
Lung cancer (father)	0.4	0.5	1.3	0.1	-0.8	-1.1	-0.7	-0.3
Illnesses of mother	1.9	2.4	4.7	-0.8	1.1	-2.0	-2.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.7	-1.9	0.2	-0.1	0.3	0.7
Pulse wave Arterial Stiffness index	0.3	0.3	1.5	0.4	0.0	-0.2	-0.2	1.2
Impedance of arm (left)	0.1	0.5	1.8	0.0	1.3	0.9	0.2	0.1
Arm fat mass (right)	0.2	0.9	1.2	-0.7	0.9	-1.1	-1.1	0.9
Trunk predicted mass	0.4	2.3	6.9	-2.6	-0.5	-1.8	-1.0	0.4
Standing height	0.2	1.7	7.3	-2.7	0.1	-0.9	-0.5	-0.2
Length of working week for main job	0.4	0.4	0.9	-1.0	1.0	0.1	-0.3	0.4
Exposure to tobacco smoke at home	4.6	5.1	7.5	-1.0	2.1	-2.3	-2.7	2.7
Breastfed as a baby	0.1	0.2	0.4	-0.3	-0.4	-0.7	0.2	-0.2
Tense / ‘highly strung’	0.1	0.1	0.2	0.3	0.2	-0.2	0.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.8	-1.3	-0.7	0.4	0.6	-1.1
Hair/balding pattern: Pattern 4	0.5	1.2	3.5	0.3	-1.9	0.3	0.7	-1.3
Birth weight of first child	0.7	1.2	3.8	-0.6	1.9	0.7	-0.6	1.0
Peak expiratory flow (PEF)	0.6	1.3	4.3	-2.1	0.7	0.8	0.9	0.7
Pulse wave reflection index	0.3	0.4	0.9	0.5	0.4	1.0	0.4	0.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.6	-0.5	1.6	-0.2	-0.2	1.1
Loud music exposure frequency	0.7	0.8	1.2	-0.5	-1.0	1.1	1.1	-0.6
Qualifications: O levels/GCSEs or equivalent	3.0	4.7	6.1	1.7	-1.8	2.5	2.4	-2.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.0	0.3	-1.7	-0.5	0.1	-1.4
Blood clot in the leg (DVT)	0.1	0.2	0.6	0.1	0.8	-0.1	-0.4	0.1
Medication: Paracetamol	1.2	2.0	3.9	-2.0	0.4	-0.9	-1.9	1.1
Headache pain in last month	0.4	0.7	1.9	0.6	0.2	1.0	1.4	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.4	0.4	-1.2	0.4	0.8	-1.1
Glaucoma (self-reported)	0.9	1.0	2.2	0.6	-1.5	0.6	1.0	-1.1
Gout (self-reported)	0.3	0.4	1.2	-1.1	0.9	0.3	0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	-0.8	0.5	-0.6	-0.4	0.4
Medication: Amlodipine	1.1	1.5	2.4	1.4	-1.5	0.8	0.6	-1.4
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	-0.9	1.2	0.1	0.7	0.5
Birth weight	1.4	3.1	6.5	-2.4	2.5	0.9	0.4	1.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.1	0.0	-0.2	0.9	0.4	-1.0
High blood pressure (siblings)	0.4	0.6	2.7	-0.3	-1.6	-0.2	-0.3	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.0	3.7	-1.9	-0.9	-0.5	0.5	0.0
Body fat percentage	0.1	0.4	1.0	-0.0	1.0	-0.1	-0.5	0.8
Leg fat percentage (right)	0.0	0.2	0.6	-0.1	0.4	0.2	-0.2	0.8
Arm fat-free mass (right)	0.3	1.5	3.5	-1.9	-1.0	-1.6	-0.6	-0.3
Exposure to tobacco smoke outside home	0.3	0.5	1.3	-0.7	0.6	-0.1	0.2	1.1
Comparative body size at age 10	0.4	1.1	4.3	-2.1	-0.2	-0.6	-0.6	0.5
Number of full brothers	3.3	4.2	9.8	-1.2	2.9	0.2	-1.0	3.1
Worry too long after embarrassment	0.8	1.4	2.5	-0.3	-0.3	-1.5	-1.4	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.9	0.1	-0.5	0.7	0.9	-1.7
Wheeze or whistling in the chest in last year	0.4	0.8	1.8	-0.4	1.4	-0.6	-0.7	0.9
Number of children fathered	2.5	2.8	4.9	-1.1	1.8	-1.4	-1.7	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.1	0.3	-1.4	1.5	1.8	-1.0
Age at first live birth	1.2	2.1	4.0	-0.7	-2.0	0.4	1.5	-1.9
Pulse wave peak to peak time	0.4	0.4	2.0	-0.3	-0.0	0.2	0.2	-1.4
Health satisfaction	0.4	0.5	0.8	-0.9	-0.8	-0.9	-0.4	-0.3
Shortness of breath walking on level ground	0.4	0.5	1.4	-1.2	0.4	-0.3	-0.1	1.0
Qualifications: College or University degree	1.1	3.4	8.7	0.6	-3.0	-0.1	1.0	-2.6
Eye problems/disorders: None of the above	0.3	0.3	1.0	-1.0	-0.7	0.1	-0.2	0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	-0.7	0.7	-0.7	-1.1	0.5
Emphysema/chronic bronchitis	0.5	0.6	1.2	-1.0	0.6	-1.1	-0.5	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	0.0	-0.2	-0.6	-0.2	0.4
Neck or shoulder pain in last month	0.3	0.4	0.9	-0.5	0.2	0.9	0.9	-0.2
Medication: Blood pressure	0.4	0.7	1.3	0.4	1.2	-0.3	-1.0	1.0
Angina (self-reported)	0.6	0.8	1.3	1.1	0.1	0.9	1.1	0.6
Migraine (self-reported)	0.7	0.9	2.0	0.8	-1.3	-0.3	-0.4	-1.4
Medication: Ibuprofen	1.1	1.3	3.5	-0.7	1.9	-0.4	-0.7	1.3
Medication: Allopurinol	0.3	0.4	1.8	0.2	-0.0	0.1	-0.2	-1.3
Medication: Omeprazole	0.9	1.1	3.0	1.0	0.0	1.7	1.2	-0.2
Medication: Seretide 50 evohaler	0.2	0.3	0.7	-0.8	0.6	0.4	0.1	0.4
Mean time to correctly identify matches	0.2	0.3	0.8	0.9	0.6	0.3	-0.3	0.5
Heart disease (mother)	0.6	0.7	2.1	-1.5	0.2	0.2	-0.2	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	-0.1	0.5	1.0	0.4	-0.5
Whole body fat mass	0.1	0.5	0.6	-0.8	0.8	-0.5	-0.6	0.7
Leg fat mass (right)	0.2	0.8	1.4	-1.0	1.0	-0.5	-0.7	1.2
Arm predicted mass (right)	0.3	1.6	3.7	-1.9	-1.0	-1.6	-0.7	-0.4
Pulse rate, automated reading	0.6	2.1	4.9	-1.3	1.2	2.2	1.1	1.1
Alcohol intake frequency.	0.4	1.0	2.3	1.5	-0.8	0.9	0.9	-0.8
Comparative height size at age 10	0.2	1.1	4.7	-2.2	-0.2	-0.3	-0.5	0.6
Number of full sisters	0.7	0.8	2.8	-0.1	-1.1	-0.1	-0.1	-1.7
Suffer from ‘nerves’	1.2	1.9	4.4	-0.3	1.9	2.1	1.0	0.6
Overall health rating	1.1	2.3	7.4	-0.3	2.7	0.4	-0.4	1.9
Chest pain or discomfort	0.2	0.3	1.1	1.1	-0.2	-0.2	-0.3	-0.4
Had major operations	0.3	0.4	1.7	1.3	-0.2	-0.2	-0.2	0.1
Age at last live birth	1.1	1.6	3.1	-0.2	-1.7	0.7	1.2	-1.8
Family relationship satisfaction	1.0	1.3	3.4	0.5	-1.8	-0.4	0.1	-1.6
Leg pain on walking	1.0	1.2	2.2	0.3	1.5	1.4	1.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.6	-0.6	1.5	0.4	-0.5	1.9
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	1.2	1.4	0.8	0.1	1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.5	0.7	-0.6	1.0	1.6	0.3
Medication: Aspirin	0.2	0.3	0.7	0.4	-0.9	-0.4	0.4	-0.2
Supplements: Vitamin C	0.8	1.0	4.2	-2.1	0.2	-0.6	0.5	0.2
Knee pain experienced in last month	1.0	1.5	2.5	-1.6	1.3	-0.6	-1.0	1.4
Hypertension (Self-reported)	0.1	0.4	1.2	1.1	-0.5	0.4	0.1	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.8	0.9	-1.9	0.9	0.8	-1.4
Illnesses of father: Heart disease	1.9	2.6	6.4	2.5	-0.1	1.8	1.8	-0.4
Illnesses of siblings: Diabetes	0.4	0.4	1.0	-0.1	0.2	-0.5	-1.0	1.0
Smoking status: Previous	1.0	1.5	3.0	-0.9	0.6	1.6	1.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	4.4	-2.1	-0.1	-0.0	-0.1	-0.3
Whole body fat-free mass	0.4	2.1	6.4	-2.5	-0.4	-1.7	-1.0	0.3
Leg fat-free mass (right)	0.3	1.7	4.9	-2.2	-0.2	-1.7	-0.9	0.3
Arm fat percentage (left)	0.2	0.7	1.2	-0.6	1.0	-0.7	-0.7	1.1
Average weekly red wine intake	0.8	1.2	2.8	1.7	1.6	-0.2	-0.5	0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	0.2	-1.2	-0.3	-0.9	-0.8
Mood swings	0.4	0.8	2.3	-0.3	-0.2	1.2	1.5	-0.2
Loneliness, isolation	0.5	0.7	1.5	-0.5	0.7	0.9	0.6	1.2
Long-standing illness, disability or infirmity	1.9	2.9	6.1	-1.2	2.0	-0.9	-2.5	1.5
Ever had bowel cancer screening	1.2	1.4	3.4	1.2	0.5	-1.4	-1.8	0.6
Diabetes diagnosed by doctor	0.2	0.3	1.1	0.1	-1.0	0.5	0.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.3	-1.5	0.3	-1.2	-1.4	0.5
Friendships satisfaction	1.0	1.3	2.6	1.1	-1.1	1.1	0.4	-1.6
Qualifications: nursing, teaching	0.5	0.8	2.8	0.4	-1.7	-0.6	0.7	-0.4
Commuting to job workplace: Walk	0.9	1.0	3.2	0.8	-0.7	0.8	1.8	0.1
Eye problems/disorders: Cataract	0.6	0.7	1.5	-1.2	1.2	-0.3	-0.3	0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.9	0.8	1.7	1.0	-0.2	0.3
Medication for cholesterol	1.2	1.9	4.5	-1.2	2.1	-0.4	-1.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.7	-0.7	0.6	-0.6	-1.3	1.0
Back pain experienced in last month	0.3	0.5	1.0	-0.5	0.9	-0.2	-1.0	0.4
Mineral and other dietary supplements	0.1	0.2	0.7	0.8	-0.2	0.4	0.1	0.0
Breast cancer (self-reported)	0.9	1.1	3.1	-1.8	-0.5	-0.8	-1.1	0.1
Asthma (self-reported)	0.6	1.2	3.4	-1.0	-0.0	1.4	1.8	0.1
Osteoporosis (self-reported)	1.5	1.8	6.6	0.3	2.6	-0.5	-1.1	0.9
Osteoarthritis (self-reported)	0.5	0.7	1.5	0.3	0.3	-1.2	-1.2	0.6
Medication: Aspirin	0.3	0.4	1.2	0.4	-1.1	-0.1	0.7	-0.5
Medication: Gliclazide	0.3	0.4	0.9	0.4	0.6	0.9	0.5	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.8	0.6	-0.5	-1.1	0.3
Smoking status: Current	0.8	1.3	3.3	-0.2	0.6	-1.4	-1.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.5	1.2	-0.4	0.3	-0.2	-0.4
Whole body water mass	0.4	2.1	6.2	-2.5	-0.4	-1.8	-1.0	0.3
Leg predicted mass (right)	0.3	1.6	4.9	-2.2	-0.1	-1.6	-0.9	0.3
Arm fat mass (left)	0.2	1.0	1.2	-1.1	0.8	-1.1	-1.0	1.1
Number of self-reported non-cancer illnesses	0.1	0.2	0.9	0.4	0.1	0.9	0.2	0.4
Average weekly champagne plus white wine intake	0.8	1.0	2.8	0.3	-1.7	-0.1	1.3	-0.8
Miserableness	0.2	0.4	0.7	0.6	-0.3	0.5	0.8	-0.8
Guilty feelings	0.1	0.2	0.6	0.8	0.2	0.2	0.2	0.5
Wears glasses or contact lenses	0.1	0.1	0.3	0.4	-0.5	-0.0	-0.1	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.8	-0.2	-0.3	-0.2	-0.5	-0.9
Hearing aid user	0.5	0.6	1.8	-1.4	0.4	-0.7	-0.5	0.1
Mother’s age at death	3.0	3.7	7.7	1.7	-2.8	0.9	1.6	-2.1
Financial situation satisfaction	0.9	1.1	4.2	-2.0	-1.0	0.0	0.2	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.6	-0.3	0.1	-0.3	0.1
Commuting to job workplace: Public transport	1.0	1.2	2.3	-1.5	-0.1	-1.3	-1.3	-0.4
Eye problems/disorders: Glaucoma	1.0	1.1	2.3	-0.4	-1.5	0.8	1.4	-0.9
Medication: Blood pressure	1.6	3.1	6.4	1.6	-2.5	1.3	1.3	-1.6
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.9	-0.1	1.6	-0.8	-0.9	1.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	0.1	0.3	-1.1	-0.7	-0.0
High cholesterol (Self-reported)	0.7	1.3	1.9	-0.9	0.6	-1.4	-1.3	1.3
Medication: Bendroflumethiazide	0.2	0.3	0.4	0.4	0.6	-0.4	-0.5	0.7
Medication: Paracetamol	1.3	2.0	5.2	-2.3	0.1	-1.1	-1.7	0.7
Medication: Lisinopril	2.2	2.8	9.7	-0.1	0.3	3.1	2.0	0.6
Medication: Atorvastatin	1.2	1.5	2.6	-1.2	1.4	-0.7	-0.9	1.6
Illnesses of father: High blood pressure	0.2	0.2	0.8	0.3	-0.9	-0.3	-0.2	-0.5
Alcohol drinker status: Never	0.9	1.0	4.7	2.2	-0.2	-0.3	-0.3	-0.5
Ever smoked	1.3	2.3	4.7	-1.9	1.8	-0.1	0.0	2.2
Basal metabolic rate	0.3	1.9	5.9	-2.4	-0.1	-1.6	-1.0	0.5
Leg fat percentage (left)	0.1	0.2	0.5	-0.1	0.6	-0.1	-0.4	0.7
Arm fat-free mass (left)	0.2	1.2	3.0	-1.7	-0.7	-1.4	-0.7	-0.1
Number of operations (self-reported)	0.4	0.6	1.9	1.4	-0.6	0.6	0.3	-0.7
Average weekly beer plus cider intake	0.1	0.1	0.3	0.3	0.5	0.1	-0.4	-0.3
Irritability	0.5	0.8	1.5	-1.0	1.2	1.1	0.4	0.4
Risk taking	0.1	0.1	0.4	-0.2	-0.2	-0.2	0.6	0.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.9	-0.1	0.4	-1.3	-2.2	0.7
Fractured/broken bones in last 5 years	0.8	1.0	2.0	1.4	-0.9	0.2	0.7	-1.2
Age started oral contraceptive pill	0.5	0.6	1.5	-0.9	0.3	-0.2	-0.7	1.2
Diastolic blood pressure, automated reading	0.4	1.1	2.7	-1.0	1.3	0.2	-0.5	1.7
Ever depressed for a whole week	0.2	0.3	0.6	-0.7	0.2	-0.4	0.1	-0.8
Unable to work because of sickness or disability	1.1	1.4	3.0	-1.4	1.7	0.8	0.1	1.2
Commuting to job workplace: Cycle	0.3	0.4	1.1	-0.5	1.1	0.6	0.4	-0.1
Myopia	0.5	0.7	1.7	1.3	0.7	0.9	0.7	0.0
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.5	-0.7	0.1	-0.2	0.1	-0.2
Cholesterol lowering medication	0.2	0.3	0.8	0.9	0.4	-0.1	-0.2	0.7
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.8	1.0	-0.3	2.2	2.0	-0.5
Pain experienced in last month	0.7	1.2	4.8	2.2	-0.8	0.5	0.5	-0.2
Supplements: Calcium	0.6	0.7	1.6	-0.3	0.5	1.3	1.1	-0.6
Basal cell carcinoma (self-reported)	0.4	0.4	1.0	-0.4	-1.0	0.4	0.1	-0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.2	-0.5	0.9	-0.0	0.0	1.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	0.1	0.7	0.5	0.3	0.1
Heart disease (siblings)	0.3	0.3	0.8	0.8	0.9	0.3	-0.1	-0.2
Alcohol drinker status: Previous	1.3	1.4	3.5	-1.8	0.0	-0.2	-0.4	1.9
Pack years of smoking	2.0	2.9	8.5	-0.5	2.1	0.0	-1.2	2.9
Impedance of whole body	0.2	1.1	3.1	0.5	1.0	1.8	0.9	-0.4
Leg fat mass (left)	0.2	0.7	0.9	-0.9	0.9	-0.7	-0.9	0.9
Arm predicted mass (left)	0.2	1.0	2.9	-1.7	-0.5	-1.2	-0.6	0.1