Hub : Genes

DGCR14

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0960 0.0330 4.7e-05 0.062 0.021 0.057 0.042 0.068 4.8e-08 1.3e-03 1.5e-07 6.6e-06 1.1e-08
2 GTEx Testis 0.2150 0.0660 1.9e-05 0.081 NA 0.134 NA 0.142 1.8e-04 NA 1.6e-06 NA 7.5e-07
3 METSIM Adipose 0.1081 0.0415 2.7e-03 0.048 0.008 0.034 0.047 0.038 8.4e-08 1.9e-02 6.4e-06 1.1e-07 1.8e-06
4 YFS Blood 0.2824 0.0461 0.0e+00 0.096 0.094 0.123 0.125 0.127 1.4e-29 5.1e-29 5.7e-38 1.4e-38 3.4e-39
5 TCGA Breast Invasive Carcinoma 0.0287 0.0182 6.9e-04 0.002 0.011 0.007 NA 0.008 9.7e-02 1.9e-03 1.4e-02 NA 8.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.6 2.1 -0.4 -0.1 -0.2 -1.5 0.8
Bipolar Disorder or Schizophrenia 0.8 2.0 3.3 -1.1 1.8 -0.4 -1.4 1.8
Depressed Affect (Nagel 2018) 0.5 1.1 2.6 1.0 0.1 1.6 1.4 -0.0
Depression (Nagel 2018) 0.6 1.0 2.8 -0.2 -0.4 1.7 1.3 -0.4
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.8 0.9 -0.7 0.7 0.3 -0.9
Neuroticism (Nagel 2018) 0.2 0.4 0.7 0.5 0.7 0.9 0.6 -0.4
Schizophrenia (2018) 1.0 2.0 5.6 -1.0 2.4 -0.4 -0.5 1.7
Schizophrenia vs Biploar Disorder 1.2 1.6 4.9 -1.2 2.2 -0.1 0.7 1.1
Worry (Nagel 2018) 0.7 1.6 2.8 1.0 0.0 1.7 1.4 -1.4
Alzheimer’s Disease (in mother) 0.4 0.5 1.3 -0.5 0.1 0.8 1.1 -0.5
Alzheimer’s Disease (in father) 0.4 0.4 0.9 0.9 -0.2 0.3 0.1 -1.0
Alzheimer’s Disease (including proxy) 0.5 0.7 1.7 0.1 0.6 1.3 1.0 -0.5
Crohns Disease (2017) 0.4 1.0 2.7 1.0 -0.2 -1.0 -1.7 -0.2
Irritable Bowel Disease (IBD) 0.4 1.1 3.1 0.4 0.2 -1.4 -1.8 0.2
Ulcerative Colitis (UC) 0.4 0.8 1.3 -0.8 0.7 -1.0 -1.1 0.8
Major Depression (MDD) 0.4 0.5 1.8 0.0 0.6 1.3 0.5 0.1
Reaction Time 0.6 1.1 2.6 -0.7 1.4 0.8 -0.1 1.6
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.2 1.0 -0.7 0.0 -0.2 -1.5
Breast Cancer 1.3 3.2 8.0 1.3 -2.4 0.1 0.7 -2.8
Ovarian Cancer 1.0 1.3 2.4 0.7 -1.4 0.5 1.1 -1.6
Prostate Cancer 1.2 1.6 4.2 1.3 -0.0 1.5 2.1 0.3
Age at First Birth 0.7 1.1 2.2 -0.5 -1.1 1.3 1.5 -0.2
Bipolar Disorder (2011) 0.1 0.1 0.4 0.0 0.1 0.6 -0.1 0.2
Body Mass Index (BMI) (2010) 0.7 1.0 2.9 -0.5 1.1 -0.0 -0.8 1.7
Coronary Artery Disease (CAD) 0.5 0.6 1.5 0.0 -1.1 0.5 0.1 -1.2
Crohns Disease (2012) 1.1 1.8 4.8 0.3 0.4 -2.0 -2.2 0.3
Mean Putamen Volume 0.9 1.1 2.3 1.5 -0.6 0.5 1.0 -1.2
Fasting Glucose 0.3 0.3 0.6 0.5 0.5 -0.6 -0.4 0.7
HbA1C 0.6 0.7 1.5 0.1 0.9 -0.6 -1.2 0.9
HDL Cholesterol 0.8 1.3 3.3 1.4 -0.9 -0.0 0.9 -1.8
LDL Cholesterol 0.1 0.1 0.4 0.2 0.2 -0.5 -0.1 0.6
Lupus 1.6 2.4 8.8 -3.0 0.3 -1.3 -1.0 0.9
Neuroticism (2016) 0.6 0.9 3.0 -0.9 1.7 0.2 -0.4 0.5
Primary Biliary Cirrhosis 0.6 0.9 1.3 0.2 1.1 -0.9 -1.1 1.1
Rheumatoid Arthritis 0.4 0.6 1.5 -0.5 1.0 0.0 -0.2 1.2
Schizophrenia (2014) 0.8 1.8 5.0 -1.1 2.2 0.1 -0.2 1.6
Triglycerides 0.6 0.9 2.6 -0.8 1.1 0.2 0.3 1.6
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.0 0.0 0.3 -0.2 -1.3 1.4
Ulcerative Colitis 1.4 2.0 3.8 0.0 1.7 -1.3 -1.3 2.0
Blood Eosinophil Count 0.2 1.2 1.7 1.3 -0.9 1.0 1.3 -0.9
Blood Platelet Count 1.2 14.1 39.3 0.0 -2.0 5.2 6.3 -0.2
Blood Red Count 0.0 0.3 1.2 -1.1 0.5 -0.0 0.3 0.4
Blood White Count 1.1 8.0 20.9 -1.5 0.3 4.6 4.0 0.8
Heel T-Score 0.5 4.4 11.4 -1.7 -1.7 2.1 3.4 -0.4
BMI 0.1 0.7 2.0 -0.6 0.6 -1.4 -0.9 0.3
Height 0.1 2.0 9.4 -3.1 -0.1 0.4 0.5 0.2
Waist Hip Ratio (WHR) 1.7 7.8 14.0 -3.7 2.9 1.5 -0.2 3.7
Systolic Blood Pressure 0.2 0.8 1.6 1.2 1.3 0.0 -0.9 0.4
Smoking Status 0.4 1.0 2.5 -1.6 0.5 0.3 0.2 1.5
Allergy or Eczema 0.3 0.8 2.7 -0.3 -1.6 0.2 0.6 -0.8
Cardiovascular Disease 0.1 0.4 0.9 -0.5 0.9 0.3 -0.5 0.6
Hypothyroidism (self reported) 0.4 0.8 1.9 -1.4 1.0 -0.1 0.1 1.0
Respiratory disease 0.2 0.5 1.5 -1.2 0.1 0.4 0.6 0.8
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.8 1.3 -0.8 0.8 0.7 -1.1
Lung FEV1/FVC ratio 0.4 2.1 4.6 -0.6 2.1 1.2 -0.5 2.0
Lung FVC 0.1 0.5 1.4 -0.7 -1.2 -0.2 0.5 0.3
Neuroticism 0.8 2.0 5.3 0.6 1.1 2.3 1.7 0.2
Chronotype (morning person) 0.4 1.0 2.0 -0.6 -1.4 -1.3 -0.3 -0.9
Hair Pigment 0.1 2.5 5.2 2.3 -1.5 0.3 0.7 -2.1
Tanning 0.2 2.0 8.0 -0.3 -2.8 0.1 0.3 -1.3
Hand grip strength (left) 0.2 0.4 1.1 0.2 -1.0 -1.0 -0.2 -0.2
Number of treatments/medications taken 0.1 0.2 0.7 -0.1 0.3 0.8 0.5 -0.1
Average weekly spirits intake 2.7 3.4 8.1 -0.9 2.9 -0.6 -1.0 2.6
Sensitivity / hurt feelings 0.7 1.2 4.0 0.2 2.0 -0.2 -1.4 0.4
Frequency of depressed mood in last 2 weeks 1.1 1.6 3.2 -1.0 -0.5 1.8 1.8 -0.3
Hearing difficulty/problems: Yes 1.7 2.6 4.2 1.2 -1.6 -2.1 -1.8 -1.2
Relative age of first facial hair 0.1 0.3 0.5 -0.5 0.7 -0.3 0.6 -0.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.4 -0.2 1.2 -0.1 -1.1 0.4
Ever used hormone-replacement therapy (HRT) 0.8 1.1 1.7 1.2 -1.3 -1.3 0.1 -0.7
Ever had hysterectomy (womb removed) 1.0 1.1 2.7 0.9 -1.7 -0.7 0.6 -1.0
Systolic blood pressure, automated reading 0.5 1.3 2.0 1.4 1.4 0.3 -0.9 1.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.6 1.3 0.1 0.2 0.5 -0.1
Angina 0.4 0.5 0.9 1.0 0.1 0.7 0.9 0.7
Medication for hormone replacement therapy 1.3 1.5 2.8 -1.4 -1.7 -1.5 0.0 -0.5
Vitamin and mineral supplements 0.4 0.5 1.8 1.3 0.0 0.5 0.7 -0.3
Supplements: Zinc 1.1 1.2 3.0 -1.7 -1.6 -0.0 0.4 0.4
Medication: Co-codamol 2.1 2.4 4.6 0.1 2.1 -1.4 -2.1 1.0
Medication: Metformin 0.1 0.2 0.6 0.8 0.2 0.5 -0.0 -0.2
Diabetes (father) 2.1 2.6 3.6 -1.9 1.8 -1.1 -1.3 1.9
Diabetes (mother) 0.8 1.0 2.2 -0.4 1.3 -0.8 -0.6 1.5
Severe depression (siblings) 0.2 0.2 0.6 -0.8 0.3 0.4 0.1 -0.0
Pack years adult smoking proportion 2.3 3.6 9.9 -0.9 2.2 -0.2 -1.4 3.1
Impedance of leg (right) 0.4 1.9 6.6 0.6 0.5 2.6 1.5 -0.5
Leg fat-free mass (left) 0.3 1.8 5.6 -2.4 -0.2 -1.5 -0.8 0.4
Trunk fat percentage 0.1 0.5 1.3 -0.2 1.2 -0.2 -0.6 0.9
Hand grip strength (right) 0.1 0.2 0.4 -0.5 -0.4 -0.1 0.6 0.5
Townsend deprivation index at recruitment 2.7 3.8 6.2 -0.8 2.5 -1.3 -2.3 2.2
Current tobacco smoking 0.7 1.1 2.6 -0.2 0.7 -1.3 -1.6 0.9
Average weekly fortified wine intake 0.6 0.7 1.9 0.1 -1.4 0.4 1.0 -0.6
Maternal smoking around birth 0.2 0.3 0.6 -0.2 -0.6 0.8 0.6 -0.5
Fed-up feelings 0.3 0.5 1.1 0.2 1.0 0.9 0.6 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.7 2.5 -0.1 0.8 1.6 0.7 0.4
Relative age voice broke 0.4 0.6 2.3 1.5 0.5 -0.3 -0.1 -0.8
Taking other prescription medications 0.5 0.8 2.5 -0.7 0.3 1.6 0.8 0.5
Age when periods started (menarche) 0.2 0.4 1.1 -0.2 0.7 0.6 1.1 -0.4
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.5 1.1 -1.3 -0.3 0.4 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.9 10.0 -0.7 -1.0 2.8 3.2 -0.0
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 4.0 1.4 -1.4 -0.1 0.4 -2.0
Qualifications: CSEs or equivalent 0.6 0.8 2.2 -0.1 -0.3 1.5 1.0 0.7
Serious illness, injury or assault to yourself 1.4 1.8 4.1 -0.2 1.7 -0.3 -1.4 2.0
High blood pressure 0.1 0.2 0.6 0.8 -0.0 0.3 -0.4 0.3
Hayfever, allergic rhinitis or eczema 0.9 1.9 5.4 0.6 -2.3 0.4 0.6 -1.8
Multivitamins +/- minerals 0.5 0.6 1.2 -0.1 -1.1 -0.5 -0.5 -1.1
Stomach or abdominal pain in last month 0.5 0.6 1.5 0.4 -0.4 1.2 1.2 -0.3
Supplements: Glucosamine 1.2 1.5 3.3 0.8 -1.8 0.1 0.9 -1.7
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 4.8 0.2 2.2 1.4 0.7 2.0
Medication: Atenolol 0.3 0.4 0.9 -0.5 0.2 -0.6 -0.5 0.9
Medication: Levothyroxine sodium 0.2 0.3 1.0 0.1 0.5 0.4 1.0 0.2
Sitting height 0.1 1.0 1.9 0.6 -0.9 -1.3 -0.6 -1.4
Chronic bronchitis/emphysema (father) 0.4 0.5 1.2 -0.9 0.6 0.4 0.1 1.1
High blood pressure (mother) 0.7 1.0 2.1 1.2 -0.7 1.4 0.9 -0.5
Body mass index (BMI) 0.2 1.0 2.1 -0.5 0.4 -1.4 -1.2 0.9
Impedance of leg (left) 0.4 1.9 5.7 0.9 0.7 2.4 1.3 -0.8
Leg predicted mass (left) 0.4 1.9 5.8 -2.4 -0.3 -1.6 -0.9 0.3
Trunk fat mass 0.2 0.7 0.9 -0.9 0.9 -0.6 -0.8 0.8
Waist circumference 0.7 2.4 4.3 -2.1 1.4 -0.9 -1.4 1.7
Number of incorrect matches in round 0.2 0.4 1.1 -1.0 0.6 0.6 0.2 0.5
Past tobacco smoking 1.2 2.3 4.9 1.7 -1.8 -0.3 -0.3 -2.2
Alcohol usually taken with meals 0.1 0.2 0.3 0.5 0.1 0.3 0.3 -0.5
Nervous feelings 0.8 1.5 2.7 1.0 -1.1 1.1 1.1 -1.6
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.3 -0.8 0.4 0.8 1.2 0.5
Hearing difficulty/problems with background noise 0.2 0.3 0.7 0.8 -0.7 0.5 -0.4 -0.1
Hair/balding pattern: Pattern 2 0.4 0.5 1.8 1.3 0.1 0.1 0.7 0.3
Had menopause 1.8 2.3 6.6 2.6 -1.0 -1.6 -1.2 -0.3
Had other major operations 1.1 1.3 2.2 1.5 -1.4 0.7 0.4 -1.3
Forced vital capacity (FVC) 0.3 1.1 2.6 -1.6 -1.3 0.2 1.1 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 5.0 -1.1 -0.7 2.0 2.2 -0.1
Ever unenthusiastic/disinterested for a whole week 1.3 1.5 5.3 -2.3 -0.9 -1.1 -0.6 0.0
Qualifications: None of the above 1.5 3.2 7.3 0.2 2.7 -1.3 -1.9 1.9
Financial difficulties in last 2 years 0.1 0.2 0.5 -0.5 -0.0 -0.1 -0.4 -0.7
Mouth/teeth dental problems 0.5 0.8 2.1 0.2 -0.5 1.1 1.4 -0.7
Heart attack 0.6 0.7 2.4 -0.6 0.8 -0.2 -0.2 1.5
Allergy 0.1 0.3 0.6 0.4 0.8 -0.3 -0.4 0.6
Pain all over the body in last month 1.9 2.1 4.0 -1.4 1.9 -0.1 -0.9 2.0
Diabetes (self-reported) 0.1 0.1 0.3 -0.3 0.1 -0.1 -0.6 0.3
Hayfever/allergic rhinitis (self-reported) 2.3 3.1 6.4 1.5 -1.2 1.5 2.5 -1.8
Medication: Ramipril 2.0 2.6 5.3 2.3 -0.5 1.8 1.7 -1.1
Medication: Simvastatin 0.5 0.7 2.3 -0.1 1.1 0.4 0.1 1.5
Fluid intelligence score 0.2 0.3 0.9 0.7 0.2 0.9 -0.0 -0.5
Illnesses of siblings 0.3 0.4 0.8 -0.7 0.3 0.4 0.9 -0.7
Neuroticism score 0.6 1.2 3.6 0.3 0.1 1.9 1.4 -0.6
Weight 0.3 1.6 2.7 -1.7 0.4 -1.6 -1.3 0.7
Impedance of arm (right) 0.2 1.0 3.6 0.2 1.9 1.2 0.2 0.4
Arm fat percentage (right) 0.2 0.9 1.6 -0.4 1.3 -0.6 -0.9 1.2
Trunk fat-free mass 0.4 2.1 6.4 -2.5 -0.5 -1.7 -0.9 0.2
Hip circumference 0.3 1.3 3.4 -0.1 0.2 -1.8 -1.9 0.1
Time employed in main current job 0.2 0.2 0.3 0.5 -0.0 -0.5 -0.6 0.2
Alcohol intake versus 10 years previously 0.9 1.3 3.1 1.1 -1.8 0.3 0.7 -1.3
Father’s age at death 0.5 0.6 2.0 -0.4 -0.8 0.1 0.6 -1.4
Worrier / anxious feelings 1.1 2.2 5.4 0.8 -1.8 0.8 1.0 -2.3
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 4.6 0.2 2.1 1.9 0.8 1.2
Falls in the last year 0.6 0.8 1.8 -1.3 1.0 -0.4 -0.8 0.7
Hair/balding pattern: Pattern 3 1.2 1.8 4.9 0.1 -0.9 -2.2 -1.9 -0.0
Number of live births 0.5 0.7 2.3 0.4 0.7 -0.2 -0.7 1.5
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.4 -1.6 -0.4 0.6 1.0 0.1
Pulse rate 0.5 0.8 1.5 -1.2 -0.0 -0.3 -1.0 1.1
Happiness 1.7 2.1 7.2 -0.1 -2.7 -0.2 0.6 -1.7
Noisy workplace 1.7 2.1 4.1 -1.2 -0.1 -2.0 -1.7 1.4
Qualifications: A levels/AS levels or equivalent 2.0 4.4 7.1 1.6 -2.4 1.3 2.7 -2.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.5 1.2 0.5 -0.1 0.2 -0.6
Mouth/teeth dental problems: Dentures 1.1 1.9 3.5 -0.4 0.5 -1.8 -1.9 1.5
Asthma 0.7 1.3 3.9 -0.7 0.2 1.5 2.0 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 3.9 -0.3 2.0 0.3 0.1 0.7
Medication: Cholesterol lowering 0.4 0.6 1.6 -0.7 0.8 0.3 -0.0 1.3
Depression (self-reported) 0.4 0.5 1.0 0.4 0.8 1.0 0.6 0.6
Medication: Lansoprazole 1.0 1.1 2.4 0.0 -1.5 0.5 1.4 -1.0
Prospective memory result 0.3 0.4 1.2 0.5 -0.7 -0.2 0.1 -1.1
Lung cancer (father) 0.4 0.5 1.3 0.1 -0.8 -1.1 -0.7 -0.3
Illnesses of mother 1.9 2.4 4.7 -0.8 1.1 -2.0 -2.2 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.7 -1.9 0.2 -0.1 0.3 0.7
Pulse wave Arterial Stiffness index 0.3 0.3 1.5 0.4 0.0 -0.2 -0.2 1.2
Impedance of arm (left) 0.1 0.5 1.8 0.0 1.3 0.9 0.2 0.1
Arm fat mass (right) 0.2 0.9 1.2 -0.7 0.9 -1.1 -1.1 0.9
Trunk predicted mass 0.4 2.3 6.9 -2.6 -0.5 -1.8 -1.0 0.4
Standing height 0.2 1.7 7.3 -2.7 0.1 -0.9 -0.5 -0.2
Length of working week for main job 0.4 0.4 0.9 -1.0 1.0 0.1 -0.3 0.4
Exposure to tobacco smoke at home 4.6 5.1 7.5 -1.0 2.1 -2.3 -2.7 2.7
Breastfed as a baby 0.1 0.2 0.4 -0.3 -0.4 -0.7 0.2 -0.2
Tense / ‘highly strung’ 0.1 0.1 0.2 0.3 0.2 -0.2 0.4 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.8 -1.3 -0.7 0.4 0.6 -1.1
Hair/balding pattern: Pattern 4 0.5 1.2 3.5 0.3 -1.9 0.3 0.7 -1.3
Birth weight of first child 0.7 1.2 3.8 -0.6 1.9 0.7 -0.6 1.0
Peak expiratory flow (PEF) 0.6 1.3 4.3 -2.1 0.7 0.8 0.9 0.7
Pulse wave reflection index 0.3 0.4 0.9 0.5 0.4 1.0 0.4 0.5
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.6 -0.5 1.6 -0.2 -0.2 1.1
Loud music exposure frequency 0.7 0.8 1.2 -0.5 -1.0 1.1 1.1 -0.6
Qualifications: O levels/GCSEs or equivalent 3.0 4.7 6.1 1.7 -1.8 2.5 2.4 -2.3
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 3.0 0.3 -1.7 -0.5 0.1 -1.4
Blood clot in the leg (DVT) 0.1 0.2 0.6 0.1 0.8 -0.1 -0.4 0.1
Medication: Paracetamol 1.2 2.0 3.9 -2.0 0.4 -0.9 -1.9 1.1
Headache pain in last month 0.4 0.7 1.9 0.6 0.2 1.0 1.4 -0.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.4 0.4 -1.2 0.4 0.8 -1.1
Glaucoma (self-reported) 0.9 1.0 2.2 0.6 -1.5 0.6 1.0 -1.1
Gout (self-reported) 0.3 0.4 1.2 -1.1 0.9 0.3 0.2 -0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.7 -0.8 0.5 -0.6 -0.4 0.4
Medication: Amlodipine 1.1 1.5 2.4 1.4 -1.5 0.8 0.6 -1.4
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.3 -0.9 1.2 0.1 0.7 0.5
Birth weight 1.4 3.1 6.5 -2.4 2.5 0.9 0.4 1.5
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.1 0.0 -0.2 0.9 0.4 -1.0
High blood pressure (siblings) 0.4 0.6 2.7 -0.3 -1.6 -0.2 -0.3 -0.3
Forced vital capacity (FVC), Best measure 0.3 1.0 3.7 -1.9 -0.9 -0.5 0.5 0.0
Body fat percentage 0.1 0.4 1.0 -0.0 1.0 -0.1 -0.5 0.8
Leg fat percentage (right) 0.0 0.2 0.6 -0.1 0.4 0.2 -0.2 0.8
Arm fat-free mass (right) 0.3 1.5 3.5 -1.9 -1.0 -1.6 -0.6 -0.3
Exposure to tobacco smoke outside home 0.3 0.5 1.3 -0.7 0.6 -0.1 0.2 1.1
Comparative body size at age 10 0.4 1.1 4.3 -2.1 -0.2 -0.6 -0.6 0.5
Number of full brothers 3.3 4.2 9.8 -1.2 2.9 0.2 -1.0 3.1
Worry too long after embarrassment 0.8 1.4 2.5 -0.3 -0.3 -1.5 -1.4 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.9 0.1 -0.5 0.7 0.9 -1.7
Wheeze or whistling in the chest in last year 0.4 0.8 1.8 -0.4 1.4 -0.6 -0.7 0.9
Number of children fathered 2.5 2.8 4.9 -1.1 1.8 -1.4 -1.7 2.2
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 3.1 0.3 -1.4 1.5 1.8 -1.0
Age at first live birth 1.2 2.1 4.0 -0.7 -2.0 0.4 1.5 -1.9
Pulse wave peak to peak time 0.4 0.4 2.0 -0.3 -0.0 0.2 0.2 -1.4
Health satisfaction 0.4 0.5 0.8 -0.9 -0.8 -0.9 -0.4 -0.3
Shortness of breath walking on level ground 0.4 0.5 1.4 -1.2 0.4 -0.3 -0.1 1.0
Qualifications: College or University degree 1.1 3.4 8.7 0.6 -3.0 -0.1 1.0 -2.6
Eye problems/disorders: None of the above 0.3 0.3 1.0 -1.0 -0.7 0.1 -0.2 0.2
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.1 -0.7 0.7 -0.7 -1.1 0.5
Emphysema/chronic bronchitis 0.5 0.6 1.2 -1.0 0.6 -1.1 -0.5 0.3
Medication for pain relief, constipation, heartburn 0.1 0.1 0.3 0.0 -0.2 -0.6 -0.2 0.4
Neck or shoulder pain in last month 0.3 0.4 0.9 -0.5 0.2 0.9 0.9 -0.2
Medication: Blood pressure 0.4 0.7 1.3 0.4 1.2 -0.3 -1.0 1.0
Angina (self-reported) 0.6 0.8 1.3 1.1 0.1 0.9 1.1 0.6
Migraine (self-reported) 0.7 0.9 2.0 0.8 -1.3 -0.3 -0.4 -1.4
Medication: Ibuprofen 1.1 1.3 3.5 -0.7 1.9 -0.4 -0.7 1.3
Medication: Allopurinol 0.3 0.4 1.8 0.2 -0.0 0.1 -0.2 -1.3
Medication: Omeprazole 0.9 1.1 3.0 1.0 0.0 1.7 1.2 -0.2
Medication: Seretide 50 evohaler 0.2 0.3 0.7 -0.8 0.6 0.4 0.1 0.4
Mean time to correctly identify matches 0.2 0.3 0.8 0.9 0.6 0.3 -0.3 0.5
Heart disease (mother) 0.6 0.7 2.1 -1.5 0.2 0.2 -0.2 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.1 -0.1 0.5 1.0 0.4 -0.5
Whole body fat mass 0.1 0.5 0.6 -0.8 0.8 -0.5 -0.6 0.7
Leg fat mass (right) 0.2 0.8 1.4 -1.0 1.0 -0.5 -0.7 1.2
Arm predicted mass (right) 0.3 1.6 3.7 -1.9 -1.0 -1.6 -0.7 -0.4
Pulse rate, automated reading 0.6 2.1 4.9 -1.3 1.2 2.2 1.1 1.1
Alcohol intake frequency. 0.4 1.0 2.3 1.5 -0.8 0.9 0.9 -0.8
Comparative height size at age 10 0.2 1.1 4.7 -2.2 -0.2 -0.3 -0.5 0.6
Number of full sisters 0.7 0.8 2.8 -0.1 -1.1 -0.1 -0.1 -1.7
Suffer from ‘nerves’ 1.2 1.9 4.4 -0.3 1.9 2.1 1.0 0.6
Overall health rating 1.1 2.3 7.4 -0.3 2.7 0.4 -0.4 1.9
Chest pain or discomfort 0.2 0.3 1.1 1.1 -0.2 -0.2 -0.3 -0.4
Had major operations 0.3 0.4 1.7 1.3 -0.2 -0.2 -0.2 0.1
Age at last live birth 1.1 1.6 3.1 -0.2 -1.7 0.7 1.2 -1.8
Family relationship satisfaction 1.0 1.3 3.4 0.5 -1.8 -0.4 0.1 -1.6
Leg pain on walking 1.0 1.2 2.2 0.3 1.5 1.4 1.1 0.8
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 3.6 -0.6 1.5 0.4 -0.5 1.9
Commuting to job workplace: Car/motor vehicle 0.9 1.0 1.9 1.2 1.4 0.8 0.1 1.2
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.5 0.7 -0.6 1.0 1.6 0.3
Medication: Aspirin 0.2 0.3 0.7 0.4 -0.9 -0.4 0.4 -0.2
Supplements: Vitamin C 0.8 1.0 4.2 -2.1 0.2 -0.6 0.5 0.2
Knee pain experienced in last month 1.0 1.5 2.5 -1.6 1.3 -0.6 -1.0 1.4
Hypertension (Self-reported) 0.1 0.4 1.2 1.1 -0.5 0.4 0.1 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.6 3.8 0.9 -1.9 0.9 0.8 -1.4
Illnesses of father: Heart disease 1.9 2.6 6.4 2.5 -0.1 1.8 1.8 -0.4
Illnesses of siblings: Diabetes 0.4 0.4 1.0 -0.1 0.2 -0.5 -1.0 1.0
Smoking status: Previous 1.0 1.5 3.0 -0.9 0.6 1.6 1.7 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 4.4 -2.1 -0.1 -0.0 -0.1 -0.3
Whole body fat-free mass 0.4 2.1 6.4 -2.5 -0.4 -1.7 -1.0 0.3
Leg fat-free mass (right) 0.3 1.7 4.9 -2.2 -0.2 -1.7 -0.9 0.3
Arm fat percentage (left) 0.2 0.7 1.2 -0.6 1.0 -0.7 -0.7 1.1
Average weekly red wine intake 0.8 1.2 2.8 1.7 1.6 -0.2 -0.5 0.6
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.4 0.2 -1.2 -0.3 -0.9 -0.8
Mood swings 0.4 0.8 2.3 -0.3 -0.2 1.2 1.5 -0.2
Loneliness, isolation 0.5 0.7 1.5 -0.5 0.7 0.9 0.6 1.2
Long-standing illness, disability or infirmity 1.9 2.9 6.1 -1.2 2.0 -0.9 -2.5 1.5
Ever had bowel cancer screening 1.2 1.4 3.4 1.2 0.5 -1.4 -1.8 0.6
Diabetes diagnosed by doctor 0.2 0.3 1.1 0.1 -1.0 0.5 0.4 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.3 -1.5 0.3 -1.2 -1.4 0.5
Friendships satisfaction 1.0 1.3 2.6 1.1 -1.1 1.1 0.4 -1.6
Qualifications: nursing, teaching 0.5 0.8 2.8 0.4 -1.7 -0.6 0.7 -0.4
Commuting to job workplace: Walk 0.9 1.0 3.2 0.8 -0.7 0.8 1.8 0.1
Eye problems/disorders: Cataract 0.6 0.7 1.5 -1.2 1.2 -0.3 -0.3 0.8
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.9 0.8 1.7 1.0 -0.2 0.3
Medication for cholesterol 1.2 1.9 4.5 -1.2 2.1 -0.4 -1.0 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.7 -0.7 0.6 -0.6 -1.3 1.0
Back pain experienced in last month 0.3 0.5 1.0 -0.5 0.9 -0.2 -1.0 0.4
Mineral and other dietary supplements 0.1 0.2 0.7 0.8 -0.2 0.4 0.1 0.0
Breast cancer (self-reported) 0.9 1.1 3.1 -1.8 -0.5 -0.8 -1.1 0.1
Asthma (self-reported) 0.6 1.2 3.4 -1.0 -0.0 1.4 1.8 0.1
Osteoporosis (self-reported) 1.5 1.8 6.6 0.3 2.6 -0.5 -1.1 0.9
Osteoarthritis (self-reported) 0.5 0.7 1.5 0.3 0.3 -1.2 -1.2 0.6
Medication: Aspirin 0.3 0.4 1.2 0.4 -1.1 -0.1 0.7 -0.5
Medication: Gliclazide 0.3 0.4 0.9 0.4 0.6 0.9 0.5 0.6
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 -0.8 0.6 -0.5 -1.1 0.3
Smoking status: Current 0.8 1.3 3.3 -0.2 0.6 -1.4 -1.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.5 1.2 -0.4 0.3 -0.2 -0.4
Whole body water mass 0.4 2.1 6.2 -2.5 -0.4 -1.8 -1.0 0.3
Leg predicted mass (right) 0.3 1.6 4.9 -2.2 -0.1 -1.6 -0.9 0.3
Arm fat mass (left) 0.2 1.0 1.2 -1.1 0.8 -1.1 -1.0 1.1
Number of self-reported non-cancer illnesses 0.1 0.2 0.9 0.4 0.1 0.9 0.2 0.4
Average weekly champagne plus white wine intake 0.8 1.0 2.8 0.3 -1.7 -0.1 1.3 -0.8
Miserableness 0.2 0.4 0.7 0.6 -0.3 0.5 0.8 -0.8
Guilty feelings 0.1 0.2 0.6 0.8 0.2 0.2 0.2 0.5
Wears glasses or contact lenses 0.1 0.1 0.3 0.4 -0.5 -0.0 -0.1 0.1
Ever taken oral contraceptive pill 0.2 0.2 0.8 -0.2 -0.3 -0.2 -0.5 -0.9
Hearing aid user 0.5 0.6 1.8 -1.4 0.4 -0.7 -0.5 0.1
Mother’s age at death 3.0 3.7 7.7 1.7 -2.8 0.9 1.6 -2.1
Financial situation satisfaction 0.9 1.1 4.2 -2.0 -1.0 0.0 0.2 0.1
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.6 -0.3 0.1 -0.3 0.1
Commuting to job workplace: Public transport 1.0 1.2 2.3 -1.5 -0.1 -1.3 -1.3 -0.4
Eye problems/disorders: Glaucoma 1.0 1.1 2.3 -0.4 -1.5 0.8 1.4 -0.9
Medication: Blood pressure 1.6 3.1 6.4 1.6 -2.5 1.3 1.3 -1.6
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.9 -0.1 1.6 -0.8 -0.9 1.7
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.3 0.1 0.3 -1.1 -0.7 -0.0
High cholesterol (Self-reported) 0.7 1.3 1.9 -0.9 0.6 -1.4 -1.3 1.3
Medication: Bendroflumethiazide 0.2 0.3 0.4 0.4 0.6 -0.4 -0.5 0.7
Medication: Paracetamol 1.3 2.0 5.2 -2.3 0.1 -1.1 -1.7 0.7
Medication: Lisinopril 2.2 2.8 9.7 -0.1 0.3 3.1 2.0 0.6
Medication: Atorvastatin 1.2 1.5 2.6 -1.2 1.4 -0.7 -0.9 1.6
Illnesses of father: High blood pressure 0.2 0.2 0.8 0.3 -0.9 -0.3 -0.2 -0.5
Alcohol drinker status: Never 0.9 1.0 4.7 2.2 -0.2 -0.3 -0.3 -0.5
Ever smoked 1.3 2.3 4.7 -1.9 1.8 -0.1 0.0 2.2
Basal metabolic rate 0.3 1.9 5.9 -2.4 -0.1 -1.6 -1.0 0.5
Leg fat percentage (left) 0.1 0.2 0.5 -0.1 0.6 -0.1 -0.4 0.7
Arm fat-free mass (left) 0.2 1.2 3.0 -1.7 -0.7 -1.4 -0.7 -0.1
Number of operations (self-reported) 0.4 0.6 1.9 1.4 -0.6 0.6 0.3 -0.7
Average weekly beer plus cider intake 0.1 0.1 0.3 0.3 0.5 0.1 -0.4 -0.3
Irritability 0.5 0.8 1.5 -1.0 1.2 1.1 0.4 0.4
Risk taking 0.1 0.1 0.4 -0.2 -0.2 -0.2 0.6 0.1
Ever had prostate specific antigen (PSA) test 1.3 1.5 4.9 -0.1 0.4 -1.3 -2.2 0.7
Fractured/broken bones in last 5 years 0.8 1.0 2.0 1.4 -0.9 0.2 0.7 -1.2
Age started oral contraceptive pill 0.5 0.6 1.5 -0.9 0.3 -0.2 -0.7 1.2
Diastolic blood pressure, automated reading 0.4 1.1 2.7 -1.0 1.3 0.2 -0.5 1.7
Ever depressed for a whole week 0.2 0.3 0.6 -0.7 0.2 -0.4 0.1 -0.8
Unable to work because of sickness or disability 1.1 1.4 3.0 -1.4 1.7 0.8 0.1 1.2
Commuting to job workplace: Cycle 0.3 0.4 1.1 -0.5 1.1 0.6 0.4 -0.1
Myopia 0.5 0.7 1.7 1.3 0.7 0.9 0.7 0.0
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.5 -0.7 0.1 -0.2 0.1 -0.2
Cholesterol lowering medication 0.2 0.3 0.8 0.9 0.4 -0.1 -0.2 0.7
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 4.8 1.0 -0.3 2.2 2.0 -0.5
Pain experienced in last month 0.7 1.2 4.8 2.2 -0.8 0.5 0.5 -0.2
Supplements: Calcium 0.6 0.7 1.6 -0.3 0.5 1.3 1.1 -0.6
Basal cell carcinoma (self-reported) 0.4 0.4 1.0 -0.4 -1.0 0.4 0.1 -0.9
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.2 -0.5 0.9 -0.0 0.0 1.5
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.5 0.1 0.7 0.5 0.3 0.1
Heart disease (siblings) 0.3 0.3 0.8 0.8 0.9 0.3 -0.1 -0.2
Alcohol drinker status: Previous 1.3 1.4 3.5 -1.8 0.0 -0.2 -0.4 1.9
Pack years of smoking 2.0 2.9 8.5 -0.5 2.1 0.0 -1.2 2.9
Impedance of whole body 0.2 1.1 3.1 0.5 1.0 1.8 0.9 -0.4
Leg fat mass (left) 0.2 0.7 0.9 -0.9 0.9 -0.7 -0.9 0.9
Arm predicted mass (left) 0.2 1.0 2.9 -1.7 -0.5 -1.2 -0.6 0.1